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Patent code US10059695

Compile Data Set for Download or QSAR
Found 67 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270592
PNG
((S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,...)
Show SMILES Cn1ccc2c(cccc2c1=O)[C@H](Nc1cc(C#N)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F
Show InChI InChI=1S/C31H31F2N9O/c1-30(2,3)16-35-27-23-13-19(12-18(14-34)25(23)36-17-37-27)38-26(24-15-42(40-39-24)31(9-10-31)29(32)33)21-6-5-7-22-20(21)8-11-41(4)28(22)43/h5-8,11-13,15,17,26,29,38H,9-10,16H2,1-4H3,(H,35,36,37)/t26-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270591
PNG
((S)-3-(((8-chloro-4- (neopentylamino) quinazolin-6...)
Show SMILES Cc1c(cccc1[C@H](Nc1cc(Cl)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F)C#N
Show InChI InChI=1S/C28H29ClF2N8/c1-16-17(12-32)6-5-7-19(16)24(22-13-39(38-37-22)28(8-9-28)26(30)31)36-18-10-20-23(21(29)11-18)34-15-35-25(20)33-14-27(2,3)4/h5-7,10-11,13,15,24,26,36H,8-9,14H2,1-4H3,(H,33,34,35)/t24-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270594
PNG
((S)-5-((1- (bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3- ...)
Show SMILES Cn1ccc2c(cccc2c1=O)[C@H](Nc1cc(Cl)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C12CC(C1)C2
Show InChI InChI=1S/C31H33ClN8O/c1-30(2,3)16-33-28-23-10-19(11-24(32)26(23)34-17-35-28)36-27(25-15-40(38-37-25)31-12-18(13-31)14-31)21-6-5-7-22-20(21)8-9-39(4)29(22)41/h5-11,15,17-18,27,36H,12-14,16H2,1-4H3,(H,33,34,35)/t18?,27-,31?/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270590
PNG
((S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,...)
Show SMILES Cc1nc(F)ccc1[C@H](Nc1cc(C#N)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F
Show InChI InChI=1S/C27H28F3N9/c1-15-18(5-6-21(28)35-15)23(20-12-39(38-37-20)27(7-8-27)25(29)30)36-17-9-16(11-31)22-19(10-17)24(34-14-33-22)32-13-26(2,3)4/h5-6,9-10,12,14,23,25,36H,7-8,13H2,1-4H3,(H,32,33,34)/t23-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270589
PNG
((S)-8-chloro-N6-((1- (1- (difluoromethyl) cyclopro...)
Show SMILES Cc1nc(F)ccc1[C@H](Nc1cc(Cl)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F
Show InChI InChI=1S/C26H28ClF3N8/c1-14-16(5-6-20(28)34-14)22(19-11-38(37-36-19)26(7-8-26)24(29)30)35-15-9-17-21(18(27)10-15)32-13-33-23(17)31-12-25(2,3)4/h5-6,9-11,13,22,24,35H,7-8,12H2,1-4H3,(H,31,32,33)/t22-/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270582
PNG
((S)-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12)C#N
Show InChI InChI=1S/C26H27FN8/c1-26(2,3)14-29-25-21-11-19(10-17(12-28)23(21)30-15-31-25)32-24(16-4-6-18(27)7-5-16)22-13-35(34-33-22)20-8-9-20/h4-7,10-11,13,15,20,24,32H,8-9,14H2,1-3H3,(H,29,30,31)
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n/an/a 2.10n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270593
PNG
((S)-5-(((8-chloro-4- (neopentylamino) quinazolin-6...)
Show SMILES Cn1ccc2c(cccc2c1=O)[C@H](Nc1cc(Cl)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F
Show InChI InChI=1S/C30H31ClF2N8O/c1-29(2,3)15-34-26-21-12-17(13-22(31)24(21)35-16-36-26)37-25(23-14-41(39-38-23)30(9-10-30)28(32)33)19-6-5-7-20-18(19)8-11-40(4)27(20)42/h5-8,11-14,16,25,28,37H,9-10,15H2,1-4H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270587
PNG
((S)-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...)
Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12)C#N
Show InChI InChI=1S/C26H27ClN8/c1-26(2,3)14-29-25-20-11-17(10-16(12-28)23(20)30-15-31-25)32-24(19-6-4-5-7-21(19)27)22-13-35(34-33-22)18-8-9-18/h4-7,10-11,13,15,18,24,32H,8-9,14H2,1-3H3,(H,29,30,31)
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n/an/a 2.40n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270575
PNG
((S)-3-((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)((4...)
Show SMILES CC(C)(C)CNc1ncnc2ccc(NC(c3cn(nn3)C3CC3)c3cccc(c3)C#N)cc12
Show InChI InChI=1S/C26H28N8/c1-26(2,3)15-28-25-21-12-19(7-10-22(21)29-16-30-25)31-24(18-6-4-5-17(11-18)13-27)23-14-34(33-32-23)20-8-9-20/h4-7,10-12,14,16,20,24,31H,8-9,15H2,1-3H3,(H,28,29,30)
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n/an/a 2.60n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270583
PNG
((S)-8-bromo-N6-((1- cyclopropyl-1H- 1,2,3-triazol-...)
Show SMILES CC(C)(C)CNc1ncnc2c(Br)cc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C25H27BrFN7/c1-25(2,3)13-28-24-19-10-17(11-20(26)23(19)29-14-30-24)31-22(15-4-6-16(27)7-5-15)21-12-34(33-32-21)18-8-9-18/h4-7,10-12,14,18,22,31H,8-9,13H2,1-3H3,(H,28,29,30)
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n/an/a 2.60n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270584
PNG
((S)-8-chloro-N6-((1- (1- (fluoromethyl) cyclopropy...)
Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3(CF)CC3)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C26H28ClF2N7/c1-25(2,3)14-30-24-19-10-18(11-20(27)23(19)31-15-32-24)33-22(16-4-6-17(29)7-5-16)21-12-36(35-34-21)26(13-28)8-9-26/h4-7,10-12,15,22,33H,8-9,13-14H2,1-3H3,(H,30,31,32)
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n/an/a 3.10n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270585
PNG
((S)-6- ((benzo[d]thiazol-7- yl(1-(1- (trifluoromet...)
Show SMILES CC(C)(C)CNc1ncnc2c(cc(N[C@H](c3cn(nn3)C3(CC3)C(F)(F)F)c3cccc4ncsc34)cc12)C#N
Show InChI InChI=1S/C28H26F3N9S/c1-26(2,3)13-33-25-19-10-17(9-16(11-32)22(19)34-14-35-25)37-23(18-5-4-6-20-24(18)41-15-36-20)21-12-40(39-38-21)27(7-8-27)28(29,30)31/h4-6,9-10,12,14-15,23,37H,7-8,13H2,1-3H3,(H,33,34,35)/t23-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270588
PNG
((S)-6-(((2- chlorophenyl)(1-(1- cyanocyclopropyl)-...)
Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3(CC3)C#N)c3ccccc3Cl)cc12)C#N
Show InChI InChI=1S/C27H26ClN9/c1-26(2,3)15-31-25-20-11-18(10-17(12-29)23(20)32-16-33-25)34-24(19-6-4-5-7-21(19)28)22-13-37(36-35-22)27(14-30)8-9-27/h4-7,10-11,13,16,24,34H,8-9,15H2,1-3H3,(H,31,32,33)
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n/an/a 3.30n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270577
PNG
((S)-8-chloro-N6-((2- chlorophenyl)(1- cyclopropyl-...)
Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12
Show InChI InChI=1S/C25H27Cl2N7/c1-25(2,3)13-28-24-18-10-15(11-20(27)22(18)29-14-30-24)31-23(17-6-4-5-7-19(17)26)21-12-34(33-32-21)16-8-9-16/h4-7,10-12,14,16,23,31H,8-9,13H2,1-3H3,(H,28,29,30)
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n/an/a 4.80n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270569
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC(C)(C)CNc1ncnc2ccc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C25H28FN7/c1-25(2,3)14-27-24-20-12-18(8-11-21(20)28-15-29-24)30-23(16-4-6-17(26)7-5-16)22-13-33(32-31-22)19-9-10-19/h4-8,11-13,15,19,23,30H,9-10,14H2,1-3H3,(H,27,28,29)
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n/an/a 5n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270598
PNG
((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...)
Show SMILES CCN1CCC(CC1)n1cc(nn1)[C@@H](Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccc1
Show InChI InChI=1S/C30H29Cl2FN8/c1-2-40-12-10-22(11-13-40)41-17-27(38-39-41)28(19-6-4-3-5-7-19)36-21-14-23-29(25(32)16-21)34-18-35-30(23)37-20-8-9-26(33)24(31)15-20/h3-9,14-18,22,28,36H,2,10-13H2,1H3,(H,34,35,37)/t28-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270570
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C25H28FN7/c1-25(2,3)14-27-24-20-12-18(8-11-21(20)28-15-29-24)30-23(16-4-6-17(26)7-5-16)22-13-33(32-31-22)19-9-10-19/h4-8,11-13,15,19,23,30H,9-10,14H2,1-3H3,(H,27,28,29)/t23-/m0/s1
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n/an/a 7.70n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270586
PNG
((S)-N6- (benzo[d]thiazol-7- yl(1-(1- (trifluoromet...)
Show SMILES CC(C)(C)CNc1ncnc2c(Br)cc(N[C@H](c3cn(nn3)C3(CC3)C(F)(F)F)c3cccc4ncsc34)cc12
Show InChI InChI=1S/C27H26BrF3N8S/c1-25(2,3)12-32-24-17-9-15(10-18(28)21(17)33-13-34-24)36-22(16-5-4-6-19-23(16)40-14-35-19)20-11-39(38-37-20)26(7-8-26)27(29,30)31/h4-6,9-11,13-14,22,36H,7-8,12H2,1-3H3,(H,32,33,34)/t22-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270603
PNG
((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- (p...)
Show SMILES Fc1ccc(Nc2ncnc3c(Cl)cc(N[C@H](c4cn(nn4)C4CCNCC4)c4ccccc4)cc23)cc1Cl
Show InChI InChI=1S/C28H25Cl2FN8/c29-22-13-18(6-7-24(22)31)36-28-21-12-19(14-23(30)27(21)33-16-34-28)35-26(17-4-2-1-3-5-17)25-15-39(38-37-25)20-8-10-32-11-9-20/h1-7,12-16,20,26,32,35H,8-11H2,(H,33,34,36)/t26-/m0/s1
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n/an/a 8.30n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270581
PNG
((S)-8-chloro-N6-((4- fluorophenyl)(1-(1- (trifluor...)
Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3(CC3)C(F)(F)F)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C26H26ClF4N7/c1-24(2,3)13-32-23-18-10-17(11-19(27)22(18)33-14-34-23)35-21(15-4-6-16(28)7-5-15)20-12-38(37-36-20)25(8-9-25)26(29,30)31/h4-7,10-12,14,21,35H,8-9,13H2,1-3H3,(H,32,33,34)
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n/an/a 10n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270571
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC1(CNc2ncnc3ccc(NC(c4cn(nn4)C4CC4)c4ccc(F)cc4)cc23)CCOCC1
Show InChI InChI=1S/C27H30FN7O/c1-27(10-12-36-13-11-27)16-29-26-22-14-20(6-9-23(22)30-17-31-26)32-25(18-2-4-19(28)5-3-18)24-15-35(34-33-24)21-7-8-21/h2-6,9,14-15,17,21,25,32H,7-8,10-13,16H2,1H3,(H,29,30,31)
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n/an/a 11n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270578
PNG
((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...)
Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(CC(O)=O)nn3)c3ccccc3Cl)cc12
Show InChI InChI=1S/C24H25Cl2N7O2/c1-24(2,3)12-27-23-16-8-14(9-18(26)21(16)28-13-29-23)30-22(15-6-4-5-7-17(15)25)19-10-33(32-31-19)11-20(34)35/h4-10,13,22,30H,11-12H2,1-3H3,(H,34,35)(H,27,28,29)
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n/an/a 13n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270576
PNG
((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...)
Show SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccccc3Cl)cc12
Show InChI InChI=1S/C25H28ClN7/c1-25(2,3)14-27-24-19-12-16(8-11-21(19)28-15-29-24)30-23(18-6-4-5-7-20(18)26)22-13-33(32-31-22)17-9-10-17/h4-8,11-13,15,17,23,30H,9-10,14H2,1-3H3,(H,27,28,29)/t23-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270604
PNG
((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...)
Show SMILES CCN1CCC(CC1)n1cc(nn1)[C@@H](Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H28Cl3FN8/c1-2-41-11-9-22(10-12-41)42-16-27(39-40-42)28(18-3-5-19(31)6-4-18)37-21-13-23-29(25(33)15-21)35-17-36-30(23)38-20-7-8-26(34)24(32)14-20/h3-8,13-17,22,28,37H,2,9-12H2,1H3,(H,35,36,38)/t28-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270597
PNG
(8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((1-(1...)
Show SMILES CCN1CCC(CC1)n1cc(nn1)C(Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccc1
Show InChI InChI=1S/C30H29Cl2FN8/c1-2-40-12-10-22(11-13-40)41-17-27(38-39-41)28(19-6-4-3-5-7-19)36-21-14-23-29(25(32)16-21)34-18-35-30(23)37-20-8-9-26(33)24(31)15-20/h3-9,14-18,22,28,36H,2,10-13H2,1H3,(H,34,35,37)
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n/an/a 19n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270596
PNG
(8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- (pheny...)
Show SMILES Fc1ccc(Nc2ncnc3c(Cl)cc(NC(c4cn(nn4)C4CCNCC4)c4ccccc4)cc23)cc1Cl
Show InChI InChI=1S/C28H25Cl2FN8/c29-22-13-18(6-7-24(22)31)36-28-21-12-19(14-23(30)27(21)33-16-34-28)35-26(17-4-2-1-3-5-17)25-15-39(38-37-25)20-8-10-32-11-9-20/h1-7,12-16,20,26,32,35H,8-11H2,(H,33,34,36)
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n/an/a 28n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270572
PNG
(N6-((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC[C@@H](Nc1ncnc2ccc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12)c1ccccc1
Show InChI InChI=1S/C29H28FN7/c1-2-25(19-6-4-3-5-7-19)34-29-24-16-22(12-15-26(24)31-18-32-29)33-28(20-8-10-21(30)11-9-20)27-17-37(36-35-27)23-13-14-23/h3-12,15-18,23,25,28,33H,2,13-14H2,1H3,(H,31,32,34)/t25-,28?/m1/s1
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n/an/a 43n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270579
PNG
((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...)
Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1
Show InChI InChI=1S/C30H26ClFN8/c31-25-16-22(36-28(20-8-10-21(32)11-9-20)27-17-40(39-38-27)23-12-13-23)15-24-29(25)34-18-35-30(24)37-26(7-4-14-33)19-5-2-1-3-6-19/h1-3,5-6,8-11,15-18,23,26,28,36H,4,7,12-13H2,(H,34,35,37)/t26-,28?/m1/s1
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n/an/a 46n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270600
PNG
((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...)
Show SMILES Fc1ccc(Nc2ncnc3ccc(N[C@H](c4cn(nn4)C4CCNCC4)c4ccc(Cl)cc4)cc23)cc1Cl
Show InChI InChI=1S/C28H25Cl2FN8/c29-18-3-1-17(2-4-18)27(26-15-39(38-37-26)21-9-11-32-12-10-21)35-19-6-8-25-22(13-19)28(34-16-33-25)36-20-5-7-24(31)23(30)14-20/h1-8,13-16,21,27,32,35H,9-12H2,(H,33,34,36)/t27-/m0/s1
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n/an/a 49n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270573
PNG
(3-((6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl...)
Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(NC(CC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1
Show InChI InChI=1S/C29H25FN8/c30-21-8-6-20(7-9-21)28(27-17-38(37-36-27)23-11-12-23)34-22-10-13-26-24(16-22)29(33-18-32-26)35-25(14-15-31)19-4-2-1-3-5-19/h1-10,13,16-18,23,25,28,34H,11-12,14H2,(H,32,33,35)
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n/an/a 53n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270599
PNG
((S)-N6-((1-(1-(tert- butyl)piperidin-4- yl)-1H-1,2...)
Show SMILES CC(C)(C)N1CCC(CC1)n1cc(nn1)[C@@H](Nc1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H33Cl2FN8/c1-32(2,3)42-14-12-24(13-15-42)43-18-29(40-41-43)30(20-4-6-21(33)7-5-20)38-22-9-11-28-25(16-22)31(37-19-36-28)39-23-8-10-27(35)26(34)17-23/h4-11,16-19,24,30,38H,12-15H2,1-3H3,(H,36,37,39)/t30-/m0/s1
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n/an/a 72n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270605
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(Nc3cnc(F)c(F)c3)c2c1)c1cn(nn1)C1CC1
Show InChI InChI=1S/C25H19F3N8/c26-15-3-1-14(2-4-15)23(22-12-36(35-34-22)18-6-7-18)32-16-5-8-21-19(9-16)25(31-13-30-21)33-17-10-20(27)24(28)29-11-17/h1-5,8-13,18,23,32H,6-7H2,(H,30,31,33)
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n/an/a 74n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270580
PNG
((R)-4-((8-chloro-6- (((S)-(4- fluorophenyl)(1-(1- ...)
Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1(CC1)C(F)(F)F
Show InChI InChI=1S/C31H25ClF4N8/c32-24-16-22(15-23-28(24)38-18-39-29(23)41-25(7-4-14-37)19-5-2-1-3-6-19)40-27(20-8-10-21(33)11-9-20)26-17-44(43-42-26)30(12-13-30)31(34,35)36/h1-3,5-6,8-11,15-18,25,27,40H,4,7,12-13H2,(H,38,39,41)/t25-,27?/m1/s1
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n/an/a 137n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270574
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES [2H]C(N(CC)c1ccc2ncnc(NCC(C)(C)C)c2c1)(c1cn(nn1)C1CC1)c1ccc(F)cc1
Show InChI InChI=1S/C27H32FN7/c1-5-34(21-12-13-23-22(14-21)26(31-17-30-23)29-16-27(2,3)4)25(18-6-8-19(28)9-7-18)24-15-35(33-32-24)20-10-11-20/h6-9,12-15,17,20,25H,5,10-11,16H2,1-4H3,(H,29,30,31)/t25-/m0/s1/i25D
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n/an/a 276n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270601
PNG
((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...)
Show SMILES Fc1ccc(Nc2ncnc3ccc(N[C@H](c4cn(nn4)C4COC4)c4ccc(Cl)cc4)cc23)cc1Cl
Show InChI InChI=1S/C26H20Cl2FN7O/c27-16-3-1-15(2-4-16)25(24-11-36(35-34-24)19-12-37-13-19)32-17-6-8-23-20(9-17)26(31-14-30-23)33-18-5-7-22(29)21(28)10-18/h1-11,14,19,25,32H,12-13H2,(H,30,31,33)/t25-/m0/s1
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n/an/a 284n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270602
PNG
((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...)
Show SMILES Fc1ccc(Nc2ncnc3ccc(N[C@H](c4cn(nn4)C4CCN(CC4)C4COC4)c4ccc(Cl)cc4)cc23)cc1Cl
Show InChI InChI=1S/C31H29Cl2FN8O/c32-20-3-1-19(2-4-20)30(29-15-42(40-39-29)23-9-11-41(12-10-23)24-16-43-17-24)37-21-6-8-28-25(13-21)31(36-18-35-28)38-22-5-7-27(34)26(33)14-22/h1-8,13-15,18,23-24,30,37H,9-12,16-17H2,(H,35,36,38)/t30-/m0/s1
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n/an/a 318n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270595
PNG
(US10059695, II-1 | benzyl 4-(4-(((8- chloro-4-((3-...)
Show SMILES Fc1ccc(Nc2ncnc3c(Cl)cc(NC(c4cn(nn4)C4CCN(CC4)C(=O)OCc4ccccc4)c4ccccc4)cc23)cc1Cl
Show InChI InChI=1S/C36H31Cl2FN8O2/c37-29-18-25(11-12-31(29)39)43-35-28-17-26(19-30(38)34(28)40-22-41-35)42-33(24-9-5-2-6-10-24)32-20-47(45-44-32)27-13-15-46(16-14-27)36(48)49-21-23-7-3-1-4-8-23/h1-12,17-20,22,27,33,42H,13-16,21H2,(H,40,41,43)
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n/an/a 8.48E+3n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270582
PNG
((S)-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12)C#N
Show InChI InChI=1S/C26H27FN8/c1-26(2,3)14-29-25-21-11-19(10-17(12-28)23(21)30-15-31-25)32-24(16-4-6-18(27)7-5-16)22-13-35(34-33-22)20-8-9-20/h4-7,10-11,13,15,20,24,32H,8-9,14H2,1-3H3,(H,29,30,31)
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n/an/an/an/a 42n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270585
PNG
((S)-6- ((benzo[d]thiazol-7- yl(1-(1- (trifluoromet...)
Show SMILES CC(C)(C)CNc1ncnc2c(cc(N[C@H](c3cn(nn3)C3(CC3)C(F)(F)F)c3cccc4ncsc34)cc12)C#N
Show InChI InChI=1S/C28H26F3N9S/c1-26(2,3)13-33-25-19-10-17(9-16(11-32)22(19)34-14-35-25)37-23(18-5-4-6-20-24(18)41-15-36-20)21-12-40(39-38-21)27(7-8-27)28(29,30)31/h4-6,9-10,12,14-15,23,37H,7-8,13H2,1-3H3,(H,33,34,35)/t23-/m0/s1
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n/an/an/an/a 59n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270579
PNG
((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...)
Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1
Show InChI InChI=1S/C30H26ClFN8/c31-25-16-22(36-28(20-8-10-21(32)11-9-20)27-17-40(39-38-27)23-12-13-23)15-24-29(25)34-18-35-30(24)37-26(7-4-14-33)19-5-2-1-3-6-19/h1-3,5-6,8-11,15-18,23,26,28,36H,4,7,12-13H2,(H,34,35,37)/t26-,28?/m1/s1
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n/an/an/an/a 671n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270580
PNG
((R)-4-((8-chloro-6- (((S)-(4- fluorophenyl)(1-(1- ...)
Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1(CC1)C(F)(F)F
Show InChI InChI=1S/C31H25ClF4N8/c32-24-16-22(15-23-28(24)38-18-39-29(23)41-25(7-4-14-37)19-5-2-1-3-6-19)40-27(20-8-10-21(33)11-9-20)26-17-44(43-42-26)30(12-13-30)31(34,35)36/h1-3,5-6,8-11,15-18,25,27,40H,4,7,12-13H2,(H,38,39,41)/t25-,27?/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270581
PNG
((S)-8-chloro-N6-((4- fluorophenyl)(1-(1- (trifluor...)
Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3(CC3)C(F)(F)F)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C26H26ClF4N7/c1-24(2,3)13-32-23-18-10-17(11-19(27)22(18)33-14-34-23)35-21(15-4-6-16(28)7-5-15)20-12-38(37-36-20)25(8-9-25)26(29,30)31/h4-7,10-12,14,21,35H,8-9,13H2,1-3H3,(H,32,33,34)
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n/an/an/an/a 181n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270586
PNG
((S)-N6- (benzo[d]thiazol-7- yl(1-(1- (trifluoromet...)
Show SMILES CC(C)(C)CNc1ncnc2c(Br)cc(N[C@H](c3cn(nn3)C3(CC3)C(F)(F)F)c3cccc4ncsc34)cc12
Show InChI InChI=1S/C27H26BrF3N8S/c1-25(2,3)12-32-24-17-9-15(10-18(28)21(17)33-13-34-24)36-22(16-5-4-6-19-23(16)40-14-35-19)20-11-39(38-37-20)26(7-8-26)27(29,30)31/h4-6,9-11,13-14,22,36H,7-8,12H2,1-3H3,(H,32,33,34)/t22-/m0/s1
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n/an/an/an/a 195n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270576
PNG
((S)-N6-((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...)
Show SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccccc3Cl)cc12
Show InChI InChI=1S/C25H28ClN7/c1-25(2,3)14-27-24-19-12-16(8-11-21(19)28-15-29-24)30-23(18-6-4-5-7-20(18)26)22-13-33(32-31-22)17-9-10-17/h4-8,11-13,15,17,23,30H,9-10,14H2,1-3H3,(H,27,28,29)/t23-/m0/s1
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n/an/an/an/a 169n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270603
PNG
((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- (p...)
Show SMILES Fc1ccc(Nc2ncnc3c(Cl)cc(N[C@H](c4cn(nn4)C4CCNCC4)c4ccccc4)cc23)cc1Cl
Show InChI InChI=1S/C28H25Cl2FN8/c29-22-13-18(6-7-24(22)31)36-28-21-12-19(14-23(30)27(21)33-16-34-28)35-26(17-4-2-1-3-5-17)25-15-39(38-37-25)20-8-10-32-11-9-20/h1-7,12-16,20,26,32,35H,8-11H2,(H,33,34,36)/t26-/m0/s1
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n/an/an/an/a 337n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270570
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC(C)(C)CNc1ncnc2ccc(N[C@H](c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C25H28FN7/c1-25(2,3)14-27-24-20-12-18(8-11-21(20)28-15-29-24)30-23(16-4-6-17(26)7-5-16)22-13-33(32-31-22)19-9-10-19/h4-8,11-13,15,19,23,30H,9-10,14H2,1-3H3,(H,27,28,29)/t23-/m0/s1
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n/an/an/an/a 85n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270584
PNG
((S)-8-chloro-N6-((1- (1- (fluoromethyl) cyclopropy...)
Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3(CF)CC3)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C26H28ClF2N7/c1-25(2,3)14-30-24-19-10-18(11-20(27)23(19)31-15-32-24)33-22(16-4-6-17(29)7-5-16)21-12-36(35-34-21)26(13-28)8-9-26/h4-7,10-12,15,22,33H,8-9,13-14H2,1-3H3,(H,30,31,32)
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n/an/an/an/a 46n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270569
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC(C)(C)CNc1ncnc2ccc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C25H28FN7/c1-25(2,3)14-27-24-20-12-18(8-11-21(20)28-15-29-24)30-23(16-4-6-17(26)7-5-16)22-13-33(32-31-22)19-9-10-19/h4-8,11-13,15,19,23,30H,9-10,14H2,1-3H3,(H,27,28,29)
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n/an/an/an/a 101n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270575
PNG
((S)-3-((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)((4...)
Show SMILES CC(C)(C)CNc1ncnc2ccc(NC(c3cn(nn3)C3CC3)c3cccc(c3)C#N)cc12
Show InChI InChI=1S/C26H28N8/c1-26(2,3)15-28-25-21-12-19(7-10-22(21)29-16-30-25)31-24(18-6-4-5-17(11-18)13-27)23-14-34(33-32-23)20-8-9-20/h4-7,10-12,14,16,20,24,31H,8-9,15H2,1-3H3,(H,28,29,30)
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n/an/an/an/a 102n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270583
PNG
((S)-8-bromo-N6-((1- cyclopropyl-1H- 1,2,3-triazol-...)
Show SMILES CC(C)(C)CNc1ncnc2c(Br)cc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C25H27BrFN7/c1-25(2,3)13-28-24-19-10-17(11-20(26)23(19)29-14-30-24)31-22(15-4-6-16(27)7-5-15)21-12-34(33-32-21)18-8-9-18/h4-7,10-12,14,18,22,31H,8-9,13H2,1-3H3,(H,28,29,30)
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n/an/an/an/a 82n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270587
PNG
((S)-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3...)
Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12)C#N
Show InChI InChI=1S/C26H27ClN8/c1-26(2,3)14-29-25-20-11-17(10-16(12-28)23(20)30-15-31-25)32-24(19-6-4-5-7-21(19)27)22-13-35(34-33-22)18-8-9-18/h4-7,10-11,13,15,18,24,32H,8-9,14H2,1-3H3,(H,29,30,31)
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n/an/an/an/a 20n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270589
PNG
((S)-8-chloro-N6-((1- (1- (difluoromethyl) cyclopro...)
Show SMILES Cc1nc(F)ccc1[C@H](Nc1cc(Cl)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F
Show InChI InChI=1S/C26H28ClF3N8/c1-14-16(5-6-20(28)34-14)22(19-11-38(37-36-19)26(7-8-26)24(29)30)35-15-9-17-21(18(27)10-15)32-13-33-23(17)31-12-25(2,3)4/h5-6,9-11,13,22,24,35H,7-8,12H2,1-4H3,(H,31,32,33)/t22-/m0/s1
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n/an/an/an/a 28n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270594
PNG
((S)-5-((1- (bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3- ...)
Show SMILES Cn1ccc2c(cccc2c1=O)[C@H](Nc1cc(Cl)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C12CC(C1)C2
Show InChI InChI=1S/C31H33ClN8O/c1-30(2,3)16-33-28-23-10-19(11-24(32)26(23)34-17-35-28)36-27(25-15-40(38-37-25)31-12-18(13-31)14-31)21-6-5-7-22-20(21)8-9-39(4)29(22)41/h5-11,15,17-18,27,36H,12-14,16H2,1-4H3,(H,33,34,35)/t18?,27-,31?/m0/s1
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n/an/an/an/a 12.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270598
PNG
((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...)
Show SMILES CCN1CCC(CC1)n1cc(nn1)[C@@H](Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccc1
Show InChI InChI=1S/C30H29Cl2FN8/c1-2-40-12-10-22(11-13-40)41-17-27(38-39-41)28(19-6-4-3-5-7-19)36-21-14-23-29(25(32)16-21)34-18-35-30(23)37-20-8-9-26(33)24(31)15-20/h3-9,14-18,22,28,36H,2,10-13H2,1H3,(H,34,35,37)/t28-/m0/s1
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n/an/an/an/a 254n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270571
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC1(CNc2ncnc3ccc(NC(c4cn(nn4)C4CC4)c4ccc(F)cc4)cc23)CCOCC1
Show InChI InChI=1S/C27H30FN7O/c1-27(10-12-36-13-11-27)16-29-26-22-14-20(6-9-23(22)30-17-31-26)32-25(18-2-4-19(28)5-3-18)24-15-35(34-33-24)21-7-8-21/h2-6,9,14-15,17,21,25,32H,7-8,10-13,16H2,1H3,(H,29,30,31)
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n/an/an/an/a 296n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270574
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES [2H]C(N(CC)c1ccc2ncnc(NCC(C)(C)C)c2c1)(c1cn(nn1)C1CC1)c1ccc(F)cc1
Show InChI InChI=1S/C27H32FN7/c1-5-34(21-12-13-23-22(14-21)26(31-17-30-23)29-16-27(2,3)4)25(18-6-8-19(28)9-7-18)24-15-35(33-32-24)20-10-11-20/h6-9,12-15,17,20,25H,5,10-11,16H2,1-4H3,(H,29,30,31)/t25-/m0/s1/i25D
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n/an/an/an/a 4.23E+3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270577
PNG
((S)-8-chloro-N6-((2- chlorophenyl)(1- cyclopropyl-...)
Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3CC3)c3ccccc3Cl)cc12
Show InChI InChI=1S/C25H27Cl2N7/c1-25(2,3)13-28-24-18-10-15(11-20(27)22(18)29-14-30-24)31-23(17-6-4-5-7-19(17)26)21-12-34(33-32-21)16-8-9-16/h4-7,10-12,14,16,23,31H,8-9,13H2,1-3H3,(H,28,29,30)
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n/an/an/an/a 86n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270578
PNG
((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...)
Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(CC(O)=O)nn3)c3ccccc3Cl)cc12
Show InChI InChI=1S/C24H25Cl2N7O2/c1-24(2,3)12-27-23-16-8-14(9-18(26)21(16)28-13-29-23)30-22(15-6-4-5-7-17(15)25)19-10-33(32-31-19)11-20(34)35/h4-10,13,22,30H,11-12H2,1-3H3,(H,34,35)(H,27,28,29)
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n/an/an/an/a>1.00E+3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270602
PNG
((S)-N4-(3-chloro-4- fluorophenyl)-N6- ((4-chloroph...)
Show SMILES Fc1ccc(Nc2ncnc3ccc(N[C@H](c4cn(nn4)C4CCN(CC4)C4COC4)c4ccc(Cl)cc4)cc23)cc1Cl
Show InChI InChI=1S/C31H29Cl2FN8O/c32-20-3-1-19(2-4-20)30(29-15-42(40-39-29)23-9-11-41(12-10-23)24-16-43-17-24)37-21-6-8-28-25(13-21)31(36-18-35-28)38-22-5-7-27(34)26(33)14-22/h1-8,13-15,18,23-24,30,37H,9-12,16-17H2,(H,35,36,38)/t30-/m0/s1
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n/an/an/an/a 1.24E+3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270572
PNG
(N6-((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES CC[C@@H](Nc1ncnc2ccc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12)c1ccccc1
Show InChI InChI=1S/C29H28FN7/c1-2-25(19-6-4-3-5-7-19)34-29-24-16-22(12-15-26(24)31-18-32-29)33-28(20-8-10-21(30)11-9-20)27-17-37(36-35-27)23-13-14-23/h3-12,15-18,23,25,28,33H,2,13-14H2,1H3,(H,31,32,34)/t25-,28?/m1/s1
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n/an/an/an/a 796n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270573
PNG
(3-((6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl...)
Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(NC(CC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1
Show InChI InChI=1S/C29H25FN8/c30-21-8-6-20(7-9-21)28(27-17-38(37-36-27)23-11-12-23)34-22-10-13-26-24(16-22)29(33-18-32-26)35-25(14-15-31)19-4-2-1-3-5-19/h1-10,13,16-18,23,25,28,34H,11-12,14H2,(H,32,33,35)
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n/an/an/an/a 2.50E+3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270588
PNG
((S)-6-(((2- chlorophenyl)(1-(1- cyanocyclopropyl)-...)
Show SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3(CC3)C#N)c3ccccc3Cl)cc12)C#N
Show InChI InChI=1S/C27H26ClN9/c1-26(2,3)15-31-25-20-11-18(10-17(12-29)23(20)32-16-33-25)34-24(19-6-4-5-7-21(19)28)22-13-37(36-35-22)27(14-30)8-9-27/h4-7,10-11,13,16,24,34H,8-9,15H2,1-3H3,(H,31,32,33)
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n/an/an/an/a 35n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270590
PNG
((S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,...)
Show SMILES Cc1nc(F)ccc1[C@H](Nc1cc(C#N)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F
Show InChI InChI=1S/C27H28F3N9/c1-15-18(5-6-21(28)35-15)23(20-12-39(38-37-20)27(7-8-27)25(29)30)36-17-9-16(11-31)22-19(10-17)24(34-14-33-22)32-13-26(2,3)4/h5-6,9-10,12,14,23,25,36H,7-8,13H2,1-4H3,(H,32,33,34)/t23-/m0/s1
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n/an/an/an/a 36n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270592
PNG
((S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,...)
Show SMILES Cn1ccc2c(cccc2c1=O)[C@H](Nc1cc(C#N)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F
Show InChI InChI=1S/C31H31F2N9O/c1-30(2,3)16-35-27-23-13-19(12-18(14-34)25(23)36-17-37-27)38-26(24-15-42(40-39-24)31(9-10-31)29(32)33)21-6-5-7-22-20(21)8-11-41(4)28(22)43/h5-8,11-13,15,17,26,29,38H,9-10,16H2,1-4H3,(H,35,36,37)/t26-/m0/s1
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n/an/an/an/a 11.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270593
PNG
((S)-5-(((8-chloro-4- (neopentylamino) quinazolin-6...)
Show SMILES Cn1ccc2c(cccc2c1=O)[C@H](Nc1cc(Cl)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F
Show InChI InChI=1S/C30H31ClF2N8O/c1-29(2,3)15-34-26-21-12-17(13-22(31)24(21)35-16-36-26)37-25(23-14-41(39-38-23)30(9-10-30)28(32)33)19-6-5-7-20-18(19)8-11-40(4)27(20)42/h5-8,11-14,16,25,28,37H,9-10,15H2,1-4H3,(H,34,35,36)/t25-/m0/s1
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n/an/an/an/a 25.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270604
PNG
((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...)
Show SMILES CCN1CCC(CC1)n1cc(nn1)[C@@H](Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H28Cl3FN8/c1-2-41-11-9-22(10-12-41)42-16-27(39-40-42)28(18-3-5-19(31)6-4-18)37-21-13-23-29(25(33)15-21)35-17-36-30(23)38-20-7-8-26(34)24(32)14-20/h3-8,13-17,22,28,37H,2,9-12H2,1H3,(H,35,36,38)/t28-/m0/s1
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n/an/an/an/a 527n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM270605
PNG
((S)-N6-((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Show SMILES Fc1ccc(cc1)C(Nc1ccc2ncnc(Nc3cnc(F)c(F)c3)c2c1)c1cn(nn1)C1CC1
Show InChI InChI=1S/C25H19F3N8/c26-15-3-1-14(2-4-15)23(22-12-36(35-34-22)18-6-7-18)32-16-5-8-21-19(9-16)25(31-13-30-21)33-17-10-20(27)24(28)29-11-17/h1-5,8-13,18,23,32H,6-7H2,(H,30,31,33)
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n/an/an/an/a 645n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...


US Patent US10059695 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%