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Patent code US10059713

Compile Data Set for Download or QSAR

Found 296 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 2


(Homo sapiens)
BDBM270887
PNG
(4-(cyclohex-1-en-1-yl)-7-[(4-methoxybenzene)sulfon...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1c(N)[nH]c2c(ncnc12)C1=CCCCC1
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n/an/an/an/a 80n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270889
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-(2,2,3-trim...)
Show SMILES CC1N(CCOC1(C)C)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
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n/an/an/an/a 47n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270915
PNG
(4-(cyclohex-1-en-1-yl)-7-{[4-(difluoromethoxy)benz...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccc(OC(F)F)cc1)C1=CCCCC1
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n/an/an/an/a 52n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270922
PNG
(7-(benzenesulfonyl)-4-(cyclohex-1-en-1-yl)-2-ethyl...)
Show SMILES CCc1nc(C2=CCCCC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270924
PNG
(4-(cyclohex-1-en-1-yl)-7-[(4-methylbenzene)sulfony...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1c(N)[nH]c2c(ncnc12)C1=CCCCC1
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n/an/an/an/a 32n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270928
PNG
(7-(benzenesulfonyl)-4-(3,3-dimethylpyrrolidin-4-yl...)
Show SMILES CC1(C)CCN(C1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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n/an/an/an/a 153n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270942
PNG
(4-cyclohexyl-7-(3,4-difluorobenzenesulfonyl)-5H-py...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccc(F)c(F)c1)C1CCCCC1
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n/an/an/an/a 182n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270956
PNG
(4-cyclopentyl-7-(4-methoxybenzenesulfonyl)-5H-pyrr...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1c(N)[nH]c2c(ncnc12)C1CCCC1
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n/an/an/an/a 9n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270958
PNG
(3-(benzenesulfonyl)-7-bromo-1H-pyrrolo[3,2-c]pyrid...)
Show SMILES Nc1[nH]c2c(Br)cncc2c1S(=O)(=O)c1ccccc1
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n/an/an/an/a 135n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270966
PNG
(7-(benzenesulfonyl)-4-(2,2-dimethylmorpholin-4-yl)...)
Show SMILES CC1(C)CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270982
PNG
(7-(benzenesulfonyl)-4-[2-(2-methylpropyl)morpholin...)
Show SMILES CC(C)CC1CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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n/an/an/an/a 145n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270984
PNG
(7-(benzenesulfonyl)-4-{6-oxa-9-azaspiro[4.5]decan-...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)N1CCOC2(CCCC2)C1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270985
PNG
(7-(benzenesulfonyl)-4-(4-methylphenyl)-5H-pyrrolo[...)
Show SMILES Cc1ccc(cc1)-c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270993
PNG
(7-(benzenesulfonyl)-2-methyl-4-(2-methylmorpholin-...)
Show SMILES CC1CN(CCO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270996
PNG
(US10059713, Example 114)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)N1CCCC(C1)n1cccn1
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n/an/an/an/a 1.11E+3n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271006
PNG
(4-(2-methylmorpholin-4-yl)-7-phenylmethanesulfonyl...)
Show SMILES CC1CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)Cc1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271007
PNG
(7-(3-fluoro-4-methoxybenzenesulfonyl)-4-(2-methylm...)
Show SMILES COc1ccc(cc1F)S(=O)(=O)c1c(N)[nH]c2c(ncnc12)N1CCOC(C)C1
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n/an/an/an/a 5.52E+3n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271023
PNG
(7-(benzenesulfonyl)-4-[2-(trifluoromethyl)morpholi...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)N1CCOC(C1)C(F)(F)F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271051
PNG
(US10059713, Example 171)
Show SMILES Nc1[nH]c2c(OCC3CC(F)(F)C3)ncnc2c1S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271065
PNG
(7-(benzenesulfonyl)-4-[2-(propan-2-yl)morpholin-4-...)
Show SMILES CC(C)C1CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271066
PNG
(4-(4,4-difluoropiperidin-1-yl)-7-(2-fluorobenzenes...)
Show SMILES Cc1nc(N2CCC(F)(F)CC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271067
PNG
(7-(benzenesulfonyl)-4-N-ethyl-4-N-(oxan-4-ylmethyl...)
Show SMILES CCN(CC1CCOCC1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271071
PNG
(4-(2-ethylmorpholin-4-yl)-7-(4-methoxybenzenesulfo...)
Show SMILES CCC1CN(CCO1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccc(OC)cc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271073
PNG
(4-(cyclopropylmethoxy)-7-(3-fluorobenzenesulfonyl)...)
Show SMILES Cc1nc(OCC2CC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cccc(F)c1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271079
PNG
(4-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-7-(3-fluoro...)
Show SMILES C[C@@H]1CN(C[C@@H](C)O1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1cccc(F)c1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271098
PNG
(7-(benzenesulfonyl)-4-[(2R,5R)-2,5-dimethylmorphol...)
Show SMILES C[C@@H]1CN([C@H](C)CO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271104
PNG
(4-[(2S,5S)-2,5-dimethylmorpholin-4-yl]-7-(2-fluoro...)
Show SMILES C[C@H]1CN([C@@H](C)CO1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1F
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n/an/an/an/a 85n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271106
PNG
(3-(benzenesulfonyl)-7-(cyclohex-1-en-1-yl)-1H-pyrr...)
Show SMILES Nc1[nH]c2c(nncc2c1S(=O)(=O)c1ccccc1)C1=CCCCC1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271112
PNG
(7-(2-fluoro-4-methoxybenzenesulfonyl)-2-methyl-4-[...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCO[C@@H](C)C1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271122
PNG
(4-(2,2-dimethylmorpholin-4-yl)-7-(2-fluoro-4-metho...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)c1c(N)[nH]c2c(nc(C)nc12)N1CCOC(C)(C)C1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271127
PNG
(US10059713, Example 248)
Show SMILES CCC(CC)Oc1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271159
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-4-(2,2-dimeth...)
Show SMILES Cc1nc(N2CCOC(C)(C)C2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
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TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271163
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-2-methyl-4-[(...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
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n/an/an/an/a 1n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271171
PNG
(7-(2-fluorobenzenesulfonyl)-2-methyl-4-[(2R)-2-(tr...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1cc(F)ccc1F
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n/an/an/an/a 3n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271174
PNG
(7-(2,6-Difluorobenzenesulfonyl)-2-methyl-4-[(2S)-2...)
Show SMILES Cc1nc(N2CCO[C@@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1c(F)cccc1F
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n/an/an/an/a 4n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271177
PNG
(7-(4-chloro-2-fluorobenzenesulfonyl)-2-methyl-4-[(...)
Show SMILES Cc1nc(N2CCO[C@H](C2)C(F)(F)F)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccc(Cl)cc1F
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n/an/an/an/a 2n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271181
PNG
(7-(2-fluorobenzenesulfonyl)-4-[2-(trifluoromethyl)...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1F)N1CCOC(C1)C(F)(F)F
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n/an/an/an/a 14n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270899
PNG
(3-(benzenesulfonyl)-7-(cyclohex-1-en-1-yl)-1H-pyrr...)
Show SMILES Nc1[nH]c2c(cncc2c1S(=O)(=O)c1ccccc1)C1=CCCCC1
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n/an/an/an/a 5.09E+3n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270902
PNG
(7-(benzenesulfonyl)-4-(cyclohex-1-en-1-yl)-2-methy...)
Show SMILES Cc1nc(C2=CCCCC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1
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n/an/an/an/a 317n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270912
PNG
(4-(azetidin-1-yl)-7-(benzenesulfonyl)-5H-pyrrolo[3...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)N1CCC1
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n/an/an/an/a 9.53E+3n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270914
PNG
(7-(benzenesulfonyl)-4-(pyrrolidin-1-yl)-5H-pyrrolo...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)N1CCCC1
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n/an/an/an/a 37n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270930
PNG
(4-(azepan-1-yl)-7-(benzenesulfonyl)-5H-pyrrolo[3,2...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)N1CCCCCC1
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n/an/an/an/a 209n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270940
PNG
(7-(benzenesulfonyl)-4-(4-methylpiperidin-1-yl)-5H-...)
Show SMILES CC1CCN(CC1)c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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n/an/an/an/a 17n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270946
PNG
(7-(benzenesulfonyl)-4-N-ethyl-5H-pyrrolo[3,2-d]pyr...)
Show SMILES CCNc1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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n/an/an/an/a 2.35E+3n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM270948
PNG
(7-(benzenesulfonyl)-4-(pyridin-4-yl)-5H-pyrrolo[3,...)
Show SMILES Nc1[nH]c2c(ncnc2c1S(=O)(=O)c1ccccc1)-c1ccncc1
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n/an/an/an/a 2.41E+3n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271020
PNG
(7-(benzenesulfonyl)-4-[(2R,6S)-2,6-dimethylmorphol...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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n/an/an/an/a 6n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271021
PNG
(7-(benzenesulfonyl)-4-(3,5-dimethyl-1H-pyrazol-1-y...)
Show SMILES Cc1cc(C)n(n1)-c1ncnc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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n/an/an/an/a 13n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271025
PNG
(7-(benzenesulfonyl)-4-(4,4-difluoropiperidin-1-yl)...)
Show SMILES Cc1nc(N2CCC(F)(F)CC2)c2[nH]c(N)c(c2n1)S(=O)(=O)c1ccccc1
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n/an/an/an/a 35n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271029
PNG
(7-(benzenesulfonyl)-2-methyl-4-(3-methylphenyl)-5H...)
Show SMILES Cc1cccc(c1)-c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1ccccc1
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n/an/an/an/a 252n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
BDBM271037
PNG
(US10059713, Example 158)
Show SMILES Nc1[nH]c2c(O[C@H]3CCOC3)ncnc2c1S(=O)(=O)c1ccccc1
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n/an/an/an/a 1.58E+3n/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
GPR43 agonist/PAM activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in...


US Patent US10059713 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%