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Patent code US10064861

Compile Data Set for Download or QSAR
Found 81 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271352
PNG
(US10064861, Compound 7)
Show SMILES O=C1Nc2nc3ccccc3n2Cc2cncc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C25H18N6O2/c32-23-9-8-20-19-11-17(12-26-13-19)14-30-22-7-2-1-6-21(22)27-25(30)28-24(33)18-5-3-4-16(10-18)15-31(23)29-20/h1-13H,14-15H2,(H,27,28,33)
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Merck Patent GmbH

US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271353
PNG
(US10064861, Compound 8)
Show SMILES Cc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C27H21N5O2/c1-17-9-10-19-14-21(17)22-11-12-25(33)32(30-22)16-18-5-4-6-20(13-18)26(34)29-27-28-23-7-2-3-8-24(23)31(27)15-19/h2-14H,15-16H2,1H3,(H,28,29,34)
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Merck Patent GmbH

US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271354
PNG
(US10064861, Compound 9)
Show SMILES O=C1Nc2nc3ccccc3n2CCOc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C27H21N5O3/c33-25-12-11-22-19-6-4-8-21(16-19)35-14-13-31-24-10-2-1-9-23(24)28-27(31)29-26(34)20-7-3-5-18(15-20)17-32(25)30-22/h1-12,15-16H,13-14,17H2,(H,28,29,34)
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Merck Patent GmbH

US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM50040732
PNG
(CHEMBL3353216 | US10064861, Compound 14)
Show SMILES O=C1Nc2nc3ccccc3n2CCn2cc(cn2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C24H19N7O2/c32-22-9-8-19-18-13-25-29(15-18)10-11-30-21-7-2-1-6-20(21)26-24(30)27-23(33)17-5-3-4-16(12-17)14-31(22)28-19/h1-9,12-13,15H,10-11,14H2,(H,26,27,33)
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n/an/a<100n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271361
PNG
(US10064861, Compound 16)
Show SMILES O=C1Nc2nc3ccccc3n2Cc2cc(ccn2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C25H18N6O2/c32-23-9-8-20-17-10-11-26-19(13-17)15-30-22-7-2-1-6-21(22)27-25(30)28-24(33)18-5-3-4-16(12-18)14-31(23)29-20/h1-13H,14-15H2,(H,27,28,33)
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Merck Patent GmbH

US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271364
PNG
(US10064861, Compound 19)
Show SMILES COc1ccc-2cc1Cn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12
Show InChI InChI=1S/C27H21N5O3/c1-35-24-11-9-18-14-20(24)16-31-23-8-3-2-7-22(23)28-27(31)29-26(34)19-6-4-5-17(13-19)15-32-25(33)12-10-21(18)30-32/h2-14H,15-16H2,1H3,(H,28,29,34)
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Merck Patent GmbH

US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271369
PNG
(US10064861, Compound 24)
Show SMILES CC1c2cccc(c2)C(=O)Nc2nc3ccccc3n2Cc2cccc(c2)-c2ccc(=O)n1n2
Show InChI InChI=1S/C27H21N5O2/c1-17-19-7-5-9-21(15-19)26(34)29-27-28-23-10-2-3-11-24(23)31(27)16-18-6-4-8-20(14-18)22-12-13-25(33)32(17)30-22/h2-15,17H,16H2,1H3,(H,28,29,34)
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Merck Patent GmbH

US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271372
PNG
(US10064861, Compound 27)
Show SMILES O=C1Nc2nc3cc(CN4CCOCC4)ccc3n2Cc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C31H28N6O3/c38-29-10-8-26-24-5-1-3-21(15-24)19-36-28-9-7-23(18-35-11-13-40-14-12-35)17-27(28)32-31(36)33-30(39)25-6-2-4-22(16-25)20-37(29)34-26/h1-10,15-17H,11-14,18-20H2,(H,32,33,39)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271375
PNG
(US10064861, Compound 30)
Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3CC(O)CCOc1n2
Show InChI InChI=1S/C24H23N5O4/c1-15-11-21(31)29-13-16-5-4-6-17(12-16)22(32)26-24-25-19-7-2-3-8-20(19)28(24)14-18(30)9-10-33-23(15)27-29/h2-8,11-12,18,30H,9-10,13-14H2,1H3,(H,25,26,32)
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Merck Patent GmbH

US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271376
PNG
(US10064861, Compound 31)
Show SMILES Oc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C26H19N5O3/c32-20-7-9-23-22(13-20)27-26-28-25(34)19-6-2-4-17(12-19)15-31-24(33)10-8-21(29-31)18-5-1-3-16(11-18)14-30(23)26/h1-13,32H,14-15H2,(H,27,28,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271380
PNG
(US10064861, Compound 34)
Show SMILES O=C1Nc2nc3ccccc3n2C\C=C/COc2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C23H19N5O3/c29-21-11-10-20-26-28(21)15-16-6-5-7-17(14-16)22(30)25-23-24-18-8-1-2-9-19(18)27(23)12-3-4-13-31-20/h1-11,14H,12-13,15H2,(H,24,25,30)/b4-3-
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271385
PNG
(US10064861, Compound 38)
Show SMILES Oc1ccc-2cc1CCn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12
Show InChI InChI=1S/C27H21N5O3/c33-24-10-8-18-15-19(24)12-13-31-23-7-2-1-6-22(23)28-27(31)29-26(35)20-5-3-4-17(14-20)16-32-25(34)11-9-21(18)30-32/h1-11,14-15,33H,12-13,16H2,(H,28,29,35)
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Merck Patent GmbH

US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271347
PNG
(US10064861, Compound 3a)
Show SMILES CN(C)C(=O)Cc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C30H26N6O3/c1-34(2)28(38)16-19-9-11-26-25(15-19)31-30-32-29(39)23-8-4-6-21(14-23)18-36-27(37)12-10-24(33-36)22-7-3-5-20(13-22)17-35(26)30/h3-15H,16-18H2,1-2H3,(H,31,32,39)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271349
PNG
(US10064861, Compound 3b)
Show SMILES CN(C)C(=O)Cc1ccc2nc3NC(=O)c4cccc(Cn5nc(ccc5=O)-c5cccc(Cn3c2c1)c5)c4
Show InChI InChI=1S/C30H26N6O3/c1-34(2)28(38)16-19-9-10-25-26(15-19)35-17-20-5-3-7-22(13-20)24-11-12-27(37)36(33-24)18-21-6-4-8-23(14-21)29(39)32-30(35)31-25/h3-15H,16-18H2,1-2H3,(H,31,32,39)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271362
PNG
(US10064861, Compound 17)
Show SMILES OC1Cn2c(NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccc1c4)c3)nc1ccccc21
Show InChI InChI=1S/C27H21N5O3/c33-24-16-31-23-10-2-1-9-22(23)28-27(31)29-26(35)20-8-3-5-17(13-20)15-32-25(34)12-11-21(30-32)18-6-4-7-19(24)14-18/h1-14,24,33H,15-16H2,(H,28,29,35)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271366
PNG
(US10064861, Compound 21)
Show SMILES OC(=O)c1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C27H19N5O4/c33-24-10-8-21-18-5-1-3-16(11-18)14-31-23-9-7-20(26(35)36)13-22(23)28-27(31)29-25(34)19-6-2-4-17(12-19)15-32(24)30-21/h1-13H,14-15H2,(H,35,36)(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271374
PNG
(US10064861, Compound 29)
Show SMILES COc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C27H21N5O3/c1-35-21-8-10-24-23(14-21)28-27-29-26(34)20-7-3-5-18(13-20)16-32-25(33)11-9-22(30-32)19-6-2-4-17(12-19)15-31(24)27/h2-14H,15-16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271377
PNG
(US10064861, Compound 32a)
Show SMILES O[C@H]1Cn2c(NC(=O)c3cccc(Cn4nc(ccc4=O)N4CCC[C@@H]1C4)c3)nc1ccccc21
Show InChI InChI=1S/C26H26N6O3/c33-22-16-31-21-9-2-1-8-20(21)27-26(31)28-25(35)18-6-3-5-17(13-18)14-32-24(34)11-10-23(29-32)30-12-4-7-19(22)15-30/h1-3,5-6,8-11,13,19,22,33H,4,7,12,14-16H2,(H,27,28,35)/t19-,22+/m1/s1
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271378
PNG
(US10064861, Compound 32b)
Show SMILES O[C@H]1Cn2c(NC(=O)c3cccc(Cn4nc(ccc4=O)N4CCC[C@H]1C4)c3)nc1ccccc21
Show InChI InChI=1S/C26H26N6O3/c33-22-16-31-21-9-2-1-8-20(21)27-26(31)28-25(35)18-6-3-5-17(13-18)14-32-24(34)11-10-23(29-32)30-12-4-7-19(22)15-30/h1-3,5-6,8-11,13,19,22,33H,4,7,12,14-16H2,(H,27,28,35)/t19-,22-/m0/s1
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271378
PNG
(US10064861, Compound 32b)
Show SMILES O[C@H]1Cn2c(NC(=O)c3cccc(Cn4nc(ccc4=O)N4CCC[C@H]1C4)c3)nc1ccccc21
Show InChI InChI=1S/C26H26N6O3/c33-22-16-31-21-9-2-1-8-20(21)27-26(31)28-25(35)18-6-3-5-17(13-18)14-32-24(34)11-10-23(29-32)30-12-4-7-19(22)15-30/h1-3,5-6,8-11,13,19,22,33H,4,7,12,14-16H2,(H,27,28,35)/t19-,22-/m0/s1
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271379
PNG
(US10064861, Compound 33)
Show SMILES COc1ccc2n3CCn4cc(cn4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C25H21N7O3/c1-35-19-5-7-22-21(12-19)27-25-28-24(34)17-4-2-3-16(11-17)14-32-23(33)8-6-20(29-32)18-13-26-30(15-18)9-10-31(22)25/h2-8,11-13,15H,9-10,14H2,1H3,(H,27,28,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271384
PNG
(US10064861, Compound 37)
Show SMILES COc1ccc-2cc1CCn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12
Show InChI InChI=1S/C28H23N5O3/c1-36-25-11-9-19-16-20(25)13-14-32-24-8-3-2-7-23(24)29-28(32)30-27(35)21-6-4-5-18(15-21)17-33-26(34)12-10-22(19)31-33/h2-12,15-16H,13-14,17H2,1H3,(H,29,30,35)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271346
PNG
(US10064861, Compound 2)
Show SMILES O=C1Nc2nc3ccccc3n2CCc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C27H21N5O2/c33-25-12-11-22-20-7-3-5-18(15-20)13-14-31-24-10-2-1-9-23(24)28-27(31)29-26(34)21-8-4-6-19(16-21)17-32(25)30-22/h1-12,15-16H,13-14,17H2,(H,28,29,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271357
PNG
(US10064861, Compound 12)
Show SMILES Oc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C26H19N5O3/c32-23-10-8-17-13-19(23)20-9-11-24(33)31(29-20)15-16-4-3-5-18(12-16)25(34)28-26-27-21-6-1-2-7-22(21)30(26)14-17/h1-13,32H,14-15H2,(H,27,28,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271360
PNG
(US10064861, Compound 15)
Show SMILES COc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C27H21N5O3/c1-35-24-11-9-18-14-20(24)21-10-12-25(33)32(30-21)16-17-5-4-6-19(13-17)26(34)29-27-28-22-7-2-3-8-23(22)31(27)15-18/h2-14H,15-16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271363
PNG
(US10064861, Compound 18)
Show SMILES OC1CCOc2ccc(=O)n(Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3C1)n2
Show InChI InChI=1S/C23H21N5O4/c29-17-10-11-32-20-8-9-21(30)28(26-20)13-15-4-3-5-16(12-15)22(31)25-23-24-18-6-1-2-7-19(18)27(23)14-17/h1-9,12,17,29H,10-11,13-14H2,(H,24,25,31)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50040733
PNG
(CHEMBL3353215 | US10064861, Compound 20)
Show SMILES Oc1ccc-2cc1Cn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12
Show InChI InChI=1S/C26H19N5O3/c32-23-10-8-17-13-19(23)15-30-22-7-2-1-6-21(22)27-26(30)28-25(34)18-5-3-4-16(12-18)14-31-24(33)11-9-20(17)29-31/h1-13,32H,14-15H2,(H,27,28,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271371
PNG
(US10064861, Compound 26)
Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3CCn3cc(cn3)-c1n2
Show InChI InChI=1S/C25H21N7O2/c1-16-11-22(33)32-14-17-5-4-6-18(12-17)24(34)28-25-27-20-7-2-3-8-21(20)31(25)10-9-30-15-19(13-26-30)23(16)29-32/h2-8,11-13,15H,9-10,14H2,1H3,(H,27,28,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271348
PNG
(US10064861, Compound 4)
Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3Cc3cccc(c3)-c1n2
Show InChI InChI=1S/C27H21N5O2/c1-17-12-24(33)32-16-19-7-5-9-21(14-19)26(34)29-27-28-22-10-2-3-11-23(22)31(27)15-18-6-4-8-20(13-18)25(17)30-32/h2-14H,15-16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271356
PNG
(US10064861, Compound 11)
Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3CCc3cccc(c3)-c1n2
Show InChI InChI=1S/C28H23N5O2/c1-18-14-25(34)33-17-20-7-5-9-22(16-20)27(35)30-28-29-23-10-2-3-11-24(23)32(28)13-12-19-6-4-8-21(15-19)26(18)31-33/h2-11,14-16H,12-13,17H2,1H3,(H,29,30,35)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271356
PNG
(US10064861, Compound 11)
Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3CCc3cccc(c3)-c1n2
Show InChI InChI=1S/C28H23N5O2/c1-18-14-25(34)33-17-20-7-5-9-22(16-20)27(35)30-28-29-23-10-2-3-11-24(23)32(28)13-12-19-6-4-8-21(15-19)26(18)31-33/h2-11,14-16H,12-13,17H2,1H3,(H,29,30,35)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50040732
PNG
(CHEMBL3353216 | US10064861, Compound 14)
Show SMILES O=C1Nc2nc3ccccc3n2CCn2cc(cn2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C24H19N7O2/c32-22-9-8-19-18-13-25-29(15-18)10-11-30-21-7-2-1-6-20(21)26-24(30)27-23(33)17-5-3-4-16(12-17)14-31(22)28-19/h1-9,12-13,15H,10-11,14H2,(H,26,27,33)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271361
PNG
(US10064861, Compound 16)
Show SMILES O=C1Nc2nc3ccccc3n2Cc2cc(ccn2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C25H18N6O2/c32-23-9-8-20-17-10-11-26-19(13-17)15-30-22-7-2-1-6-21(22)27-25(30)28-24(33)18-5-3-4-16(12-18)14-31(23)29-20/h1-13H,14-15H2,(H,27,28,33)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271362
PNG
(US10064861, Compound 17)
Show SMILES OC1Cn2c(NC(=O)c3cccc(Cn4nc(ccc4=O)-c4cccc1c4)c3)nc1ccccc21
Show InChI InChI=1S/C27H21N5O3/c33-24-16-31-23-10-2-1-9-22(23)28-27(31)29-26(35)20-8-3-5-17(13-20)15-32-25(34)12-11-21(30-32)18-6-4-7-19(24)14-18/h1-14,24,33H,15-16H2,(H,28,29,35)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM50040733
PNG
(CHEMBL3353215 | US10064861, Compound 20)
Show SMILES Oc1ccc-2cc1Cn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12
Show InChI InChI=1S/C26H19N5O3/c32-23-10-8-17-13-19(23)15-30-22-7-2-1-6-21(22)27-26(30)28-25(34)18-5-3-4-16(12-18)14-31-24(33)11-9-20(17)29-31/h1-13,32H,14-15H2,(H,27,28,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271367
PNG
(US10064861, Compound 22)
Show SMILES COc1cc2nc3NC(=O)c4cccc(Cn5nc(ccc5=O)-c5cnn(CCn3c2cc1OC)c5)c4
Show InChI InChI=1S/C26H23N7O4/c1-36-22-11-20-21(12-23(22)37-2)32-9-8-31-15-18(13-27-31)19-6-7-24(34)33(30-19)14-16-4-3-5-17(10-16)25(35)29-26(32)28-20/h3-7,10-13,15H,8-9,14H2,1-2H3,(H,28,29,35)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271367
PNG
(US10064861, Compound 22)
Show SMILES COc1cc2nc3NC(=O)c4cccc(Cn5nc(ccc5=O)-c5cnn(CCn3c2cc1OC)c5)c4
Show InChI InChI=1S/C26H23N7O4/c1-36-22-11-20-21(12-23(22)37-2)32-9-8-31-15-18(13-27-31)19-6-7-24(34)33(30-19)14-16-4-3-5-17(10-16)25(35)29-26(32)28-20/h3-7,10-13,15H,8-9,14H2,1-2H3,(H,28,29,35)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271385
PNG
(US10064861, Compound 38)
Show SMILES Oc1ccc-2cc1CCn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12
Show InChI InChI=1S/C27H21N5O3/c33-24-10-8-18-15-19(24)12-13-31-23-7-2-1-6-22(23)28-27(31)29-26(35)20-5-3-4-17(14-20)16-32-25(34)11-9-21(18)30-32/h1-11,14-15,33H,12-13,16H2,(H,28,29,35)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271345
PNG
(US10064861, Compound 1)
Show SMILES O=C1Nc2nc3ccccc3n2Cc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C26H19N5O2/c32-24-12-11-21-19-7-3-5-17(13-19)15-30-23-10-2-1-9-22(23)27-26(30)28-25(33)20-8-4-6-18(14-20)16-31(24)29-21/h1-14H,15-16H2,(H,27,28,33)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271349
PNG
(US10064861, Compound 3b)
Show SMILES CN(C)C(=O)Cc1ccc2nc3NC(=O)c4cccc(Cn5nc(ccc5=O)-c5cccc(Cn3c2c1)c5)c4
Show InChI InChI=1S/C30H26N6O3/c1-34(2)28(38)16-19-9-10-25-26(15-19)35-17-20-5-3-7-22(13-20)24-11-12-27(37)36(33-24)18-21-6-4-8-23(14-21)29(39)32-30(35)31-25/h3-15H,16-18H2,1-2H3,(H,31,32,39)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271351
PNG
(US10064861, Compound 6)
Show SMILES Fc1cc2nc3NC(=O)c4cccc(Cn5nc(ccc5=O)-c5cccc(Cn3c2cc1F)c5)c4
Show InChI InChI=1S/C26H17F2N5O2/c27-19-11-22-23(12-20(19)28)32-13-15-3-1-5-17(9-15)21-7-8-24(34)33(31-21)14-16-4-2-6-18(10-16)25(35)30-26(32)29-22/h1-12H,13-14H2,(H,29,30,35)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271353
PNG
(US10064861, Compound 8)
Show SMILES Cc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C27H21N5O2/c1-17-9-10-19-14-21(17)22-11-12-25(33)32(30-22)16-18-5-4-6-20(13-18)26(34)29-27-28-23-7-2-3-8-24(23)31(27)15-19/h2-14H,15-16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271360
PNG
(US10064861, Compound 15)
Show SMILES COc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C27H21N5O3/c1-35-24-11-9-18-14-20(24)21-10-12-25(33)32(30-21)16-17-5-4-6-19(13-17)26(34)29-27-28-22-7-2-3-8-23(22)31(27)15-18/h2-14H,15-16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271363
PNG
(US10064861, Compound 18)
Show SMILES OC1CCOc2ccc(=O)n(Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3C1)n2
Show InChI InChI=1S/C23H21N5O4/c29-17-10-11-32-20-8-9-21(30)28(26-20)13-15-4-3-5-16(12-15)22(31)25-23-24-18-6-1-2-7-19(18)27(23)14-17/h1-9,12,17,29H,10-11,13-14H2,(H,24,25,31)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271368
PNG
(US10064861, Compound 23)
Show SMILES NCCc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C28H24N6O2/c29-12-11-18-7-9-25-24(15-18)30-28-31-27(36)22-6-2-4-20(14-22)17-34-26(35)10-8-23(32-34)21-5-1-3-19(13-21)16-33(25)28/h1-10,13-15H,11-12,16-17,29H2,(H,30,31,36)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271370
PNG
(US10064861, Compound 25)
Show SMILES CC(=O)NCCc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C30H26N6O3/c1-19(37)31-13-12-20-8-10-27-26(16-20)32-30-33-29(39)24-7-3-5-22(15-24)18-36-28(38)11-9-25(34-36)23-6-2-4-21(14-23)17-35(27)30/h2-11,14-16H,12-13,17-18H2,1H3,(H,31,37)(H,32,33,39)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271380
PNG
(US10064861, Compound 34)
Show SMILES O=C1Nc2nc3ccccc3n2C\C=C/COc2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C23H19N5O3/c29-21-11-10-20-26-28(21)15-16-6-5-7-17(14-16)22(30)25-23-24-18-8-1-2-9-19(18)27(23)12-3-4-13-31-20/h1-11,14H,12-13,15H2,(H,24,25,30)/b4-3-
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271381
PNG
(US10064861, Compound 35)
Show SMILES COc1ccc2n3CC(O)CCOc4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C24H23N5O5/c1-33-18-5-6-20-19(12-18)25-24-26-23(32)16-4-2-3-15(11-16)13-29-22(31)8-7-21(27-29)34-10-9-17(30)14-28(20)24/h2-8,11-12,17,30H,9-10,13-14H2,1H3,(H,25,26,32)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271382
PNG
(US10064861, Compound 36a)
Show SMILES CC[C@H]1c2cccc(c2)C(=O)Nc2nc3ccccc3n2Cc2cccc(c2)-c2ccc(=O)n1n2
Show InChI InChI=1S/C28H23N5O2/c1-2-24-20-9-6-10-21(16-20)27(35)30-28-29-23-11-3-4-12-25(23)32(28)17-18-7-5-8-19(15-18)22-13-14-26(34)33(24)31-22/h3-16,24H,2,17H2,1H3,(H,29,30,35)/t24-/m0/s1
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271384
PNG
(US10064861, Compound 37)
Show SMILES COc1ccc-2cc1CCn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12
Show InChI InChI=1S/C28H23N5O3/c1-36-25-11-9-19-16-20(25)13-14-32-24-8-3-2-7-23(24)29-28(32)30-27(35)21-6-4-5-18(15-21)17-33-26(34)12-10-22(19)31-33/h2-12,15-16H,13-14,17H2,1H3,(H,29,30,35)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271345
PNG
(US10064861, Compound 1)
Show SMILES O=C1Nc2nc3ccccc3n2Cc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C26H19N5O2/c32-24-12-11-21-19-7-3-5-17(13-19)15-30-23-10-2-1-9-22(23)27-26(30)28-25(33)20-8-4-6-18(14-20)16-31(24)29-21/h1-14H,15-16H2,(H,27,28,33)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271346
PNG
(US10064861, Compound 2)
Show SMILES O=C1Nc2nc3ccccc3n2CCc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C27H21N5O2/c33-25-12-11-22-20-7-3-5-18(15-20)13-14-31-24-10-2-1-9-23(24)28-27(31)29-26(34)21-8-4-6-19(16-21)17-32(25)30-22/h1-12,15-16H,13-14,17H2,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271347
PNG
(US10064861, Compound 3a)
Show SMILES CN(C)C(=O)Cc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C30H26N6O3/c1-34(2)28(38)16-19-9-11-26-25(15-19)31-30-32-29(39)23-8-4-6-21(14-23)18-36-27(37)12-10-24(33-36)22-7-3-5-20(13-22)17-35(26)30/h3-15H,16-18H2,1-2H3,(H,31,32,39)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271355
PNG
(US10064861, Compound 10)
Show SMILES Fc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C26H18FN5O2/c27-20-9-8-17-13-19(20)21-10-11-24(33)32(30-21)15-16-4-3-5-18(12-16)25(34)29-26-28-22-6-1-2-7-23(22)31(26)14-17/h1-13H,14-15H2,(H,28,29,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271369
PNG
(US10064861, Compound 24)
Show SMILES CC1c2cccc(c2)C(=O)Nc2nc3ccccc3n2Cc2cccc(c2)-c2ccc(=O)n1n2
Show InChI InChI=1S/C27H21N5O2/c1-17-19-7-5-9-21(15-19)26(34)29-27-28-23-10-2-3-11-24(23)31(27)16-18-6-4-8-20(14-18)22-12-13-25(33)32(17)30-22/h2-15,17H,16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271370
PNG
(US10064861, Compound 25)
Show SMILES CC(=O)NCCc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C30H26N6O3/c1-19(37)31-13-12-20-8-10-27-26(16-20)32-30-33-29(39)24-7-3-5-22(15-24)18-36-28(38)11-9-25(34-36)23-6-2-4-21(14-23)17-35(27)30/h2-11,14-16H,12-13,17-18H2,1H3,(H,31,37)(H,32,33,39)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271374
PNG
(US10064861, Compound 29)
Show SMILES COc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C27H21N5O3/c1-35-21-8-10-24-23(14-21)28-27-29-26(34)20-7-3-5-18(13-20)16-32-25(33)11-9-22(30-32)19-6-2-4-17(12-19)15-31(24)27/h2-14H,15-16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271382
PNG
(US10064861, Compound 36a)
Show SMILES CC[C@H]1c2cccc(c2)C(=O)Nc2nc3ccccc3n2Cc2cccc(c2)-c2ccc(=O)n1n2
Show InChI InChI=1S/C28H23N5O2/c1-2-24-20-9-6-10-21(16-20)27(35)30-28-29-23-11-3-4-12-25(23)32(28)17-18-7-5-8-19(15-18)22-13-14-26(34)33(24)31-22/h3-16,24H,2,17H2,1H3,(H,29,30,35)/t24-/m0/s1
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271350
PNG
(US10064861, Compound 5)
Show SMILES COc1cc2nc3NC(=O)c4cccc(Cn5nc(ccc5=O)-c5cccc(Cn3c2cc1OC)c5)c4
Show InChI InChI=1S/C28H23N5O4/c1-36-24-13-22-23(14-25(24)37-2)32-15-17-5-3-7-19(11-17)21-9-10-26(34)33(31-21)16-18-6-4-8-20(12-18)27(35)30-28(32)29-22/h3-14H,15-16H2,1-2H3,(H,29,30,35)
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Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271358
PNG
(US10064861, Compound 13)
Show SMILES Clc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C26H18ClN5O2/c27-20-9-8-17-13-19(20)21-10-11-24(33)32(30-21)15-16-4-3-5-18(12-16)25(34)29-26-28-22-6-1-2-7-23(22)31(26)14-17/h1-13H,14-15H2,(H,28,29,34)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271368
PNG
(US10064861, Compound 23)
Show SMILES NCCc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C28H24N6O2/c29-12-11-18-7-9-25-24(15-18)30-28-31-27(36)22-6-2-4-20(14-22)17-34-26(35)10-8-23(32-34)21-5-1-3-19(13-21)16-33(25)28/h1-10,13-15H,11-12,16-17,29H2,(H,30,31,36)
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Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271379
PNG
(US10064861, Compound 33)
Show SMILES COc1ccc2n3CCn4cc(cn4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C25H21N7O3/c1-35-19-5-7-22-21(12-19)27-25-28-24(34)17-4-2-3-16(11-17)14-32-23(33)8-6-20(29-32)18-13-26-30(15-18)9-10-31(22)25/h2-8,11-13,15H,9-10,14H2,1H3,(H,27,28,34)
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Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271381
PNG
(US10064861, Compound 35)
Show SMILES COc1ccc2n3CC(O)CCOc4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C24H23N5O5/c1-33-18-5-6-20-19(12-18)25-24-26-23(32)16-4-2-3-15(11-16)13-29-22(31)8-7-21(27-29)34-10-9-17(30)14-28(20)24/h2-8,11-12,17,30H,9-10,13-14H2,1H3,(H,25,26,32)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271350
PNG
(US10064861, Compound 5)
Show SMILES COc1cc2nc3NC(=O)c4cccc(Cn5nc(ccc5=O)-c5cccc(Cn3c2cc1OC)c5)c4
Show InChI InChI=1S/C28H23N5O4/c1-36-24-13-22-23(14-25(24)37-2)32-15-17-5-3-7-19(11-17)21-9-10-26(34)33(31-21)16-18-6-4-8-20(12-18)27(35)30-28(32)29-22/h3-14H,15-16H2,1-2H3,(H,29,30,35)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271357
PNG
(US10064861, Compound 12)
Show SMILES Oc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C26H19N5O3/c32-23-10-8-17-13-19(23)20-9-11-24(33)31(29-20)15-16-4-3-5-18(12-16)25(34)28-26-27-21-6-1-2-7-22(21)30(26)14-17/h1-13,32H,14-15H2,(H,27,28,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271366
PNG
(US10064861, Compound 21)
Show SMILES OC(=O)c1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C27H19N5O4/c33-24-10-8-21-18-5-1-3-16(11-18)14-31-23-9-7-20(26(35)36)13-22(23)28-27(31)29-25(34)19-6-2-4-17(12-19)15-32(24)30-21/h1-13H,14-15H2,(H,35,36)(H,28,29,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271371
PNG
(US10064861, Compound 26)
Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3CCn3cc(cn3)-c1n2
Show InChI InChI=1S/C25H21N7O2/c1-16-11-22(33)32-14-17-5-4-6-18(12-17)24(34)28-25-27-20-7-2-3-8-21(20)31(25)10-9-30-15-19(13-26-30)23(16)29-32/h2-8,11-13,15H,9-10,14H2,1H3,(H,27,28,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271372
PNG
(US10064861, Compound 27)
Show SMILES O=C1Nc2nc3cc(CN4CCOCC4)ccc3n2Cc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C31H28N6O3/c38-29-10-8-26-24-5-1-3-21(15-24)19-36-28-9-7-23(18-35-11-13-40-14-12-35)17-27(28)32-31(36)33-30(39)25-6-2-4-22(16-25)20-37(29)34-26/h1-10,15-17H,11-14,18-20H2,(H,32,33,39)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271375
PNG
(US10064861, Compound 30)
Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3CC(O)CCOc1n2
Show InChI InChI=1S/C24H23N5O4/c1-15-11-21(31)29-13-16-5-4-6-17(12-16)22(32)26-24-25-19-7-2-3-8-20(19)28(24)14-18(30)9-10-33-23(15)27-29/h2-8,11-12,18,30H,9-10,13-14H2,1H3,(H,25,26,32)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271377
PNG
(US10064861, Compound 32a)
Show SMILES O[C@H]1Cn2c(NC(=O)c3cccc(Cn4nc(ccc4=O)N4CCC[C@@H]1C4)c3)nc1ccccc21
Show InChI InChI=1S/C26H26N6O3/c33-22-16-31-21-9-2-1-8-20(21)27-26(31)28-25(35)18-6-3-5-17(13-18)14-32-24(34)11-10-23(29-32)30-12-4-7-19(22)15-30/h1-3,5-6,8-11,13,19,22,33H,4,7,12,14-16H2,(H,27,28,35)/t19-,22+/m1/s1
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271383
PNG
(US10064861, Compound 36b)
Show SMILES CC[C@@H]1c2cccc(c2)C(=O)Nc2nc3ccccc3n2Cc2cccc(c2)-c2ccc(=O)n1n2
Show InChI InChI=1S/C28H23N5O2/c1-2-24-20-9-6-10-21(16-20)27(35)30-28-29-23-11-3-4-12-25(23)32(28)17-18-7-5-8-19(15-18)22-13-14-26(34)33(24)31-22/h3-16,24H,2,17H2,1H3,(H,29,30,35)/t24-/m1/s1
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271354
PNG
(US10064861, Compound 9)
Show SMILES O=C1Nc2nc3ccccc3n2CCOc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2
Show InChI InChI=1S/C27H21N5O3/c33-25-12-11-22-19-6-4-8-21(16-19)35-14-13-31-24-10-2-1-9-23(24)28-27(31)29-26(34)20-7-3-5-18(15-20)17-32(25)30-22/h1-12,15-16H,13-14,17H2,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271355
PNG
(US10064861, Compound 10)
Show SMILES Fc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C26H18FN5O2/c27-20-9-8-17-13-19(20)21-10-11-24(33)32(30-21)15-16-4-3-5-18(12-16)25(34)29-26-28-22-6-1-2-7-23(22)31(26)14-17/h1-13H,14-15H2,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271364
PNG
(US10064861, Compound 19)
Show SMILES COc1ccc-2cc1Cn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12
Show InChI InChI=1S/C27H21N5O3/c1-35-24-11-9-18-14-20(24)16-31-23-8-3-2-7-22(23)28-27(31)29-26(34)19-6-4-5-17(13-19)15-32-25(33)12-10-21(18)30-32/h2-14H,15-16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1


(Homo sapiens (Human))
BDBM271373
PNG
(US10064861, Compound 28)
Show SMILES Cc1nn2CCn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2C)c4)nc1ccccc31
Show InChI InChI=1S/C26H23N7O2/c1-16-24-17(2)32(29-16)13-12-31-22-9-4-3-8-20(22)27-26(31)28-25(35)19-7-5-6-18(14-19)15-33-23(34)11-10-21(24)30-33/h3-11,14H,12-13,15H2,1-2H3,(H,27,28,35)
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US Patent


Assay Description
IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271358
PNG
(US10064861, Compound 13)
Show SMILES Clc1ccc2Cn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2)c4)nc1ccccc31
Show InChI InChI=1S/C26H18ClN5O2/c27-20-9-8-17-13-19(20)21-10-11-24(33)32(30-21)15-16-4-3-5-18(12-16)25(34)29-26-28-22-6-1-2-7-23(22)31(26)14-17/h1-13H,14-15H2,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271351
PNG
(US10064861, Compound 6)
Show SMILES Fc1cc2nc3NC(=O)c4cccc(Cn5nc(ccc5=O)-c5cccc(Cn3c2cc1F)c5)c4
Show InChI InChI=1S/C26H17F2N5O2/c27-19-11-22-23(12-20(19)28)32-13-15-3-1-5-17(9-15)21-7-8-24(34)33(31-21)14-16-4-2-6-18(10-16)25(35)30-26(32)29-22/h1-12H,13-14H2,(H,29,30,35)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271373
PNG
(US10064861, Compound 28)
Show SMILES Cc1nn2CCn3c(NC(=O)c4cccc(Cn5nc(ccc5=O)-c1c2C)c4)nc1ccccc31
Show InChI InChI=1S/C26H23N7O2/c1-16-24-17(2)32(29-16)13-12-31-22-9-4-3-8-20(22)27-26(31)28-25(35)19-7-5-6-18(14-19)15-33-23(34)11-10-21(24)30-33/h3-11,14H,12-13,15H2,1-2H3,(H,27,28,35)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271383
PNG
(US10064861, Compound 36b)
Show SMILES CC[C@@H]1c2cccc(c2)C(=O)Nc2nc3ccccc3n2Cc2cccc(c2)-c2ccc(=O)n1n2
Show InChI InChI=1S/C28H23N5O2/c1-2-24-20-9-6-10-21(16-20)27(35)30-28-29-23-11-3-4-12-25(23)32(28)17-18-7-5-8-19(15-18)22-13-14-26(34)33(24)31-22/h3-16,24H,2,17H2,1H3,(H,29,30,35)/t24-/m1/s1
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271348
PNG
(US10064861, Compound 4)
Show SMILES Cc1cc(=O)n2Cc3cccc(c3)C(=O)Nc3nc4ccccc4n3Cc3cccc(c3)-c1n2
Show InChI InChI=1S/C27H21N5O2/c1-17-12-24(33)32-16-19-7-5-9-21(14-19)26(34)29-27-28-22-10-2-3-11-23(22)31(27)15-18-6-4-8-20(13-18)25(17)30-32/h2-14H,15-16H2,1H3,(H,28,29,34)
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US Patent


Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM271376
PNG
(US10064861, Compound 31)
Show SMILES Oc1ccc2n3Cc4cccc(c4)-c4ccc(=O)n(Cc5cccc(c5)C(=O)Nc3nc2c1)n4
Show InChI InChI=1S/C26H19N5O3/c32-20-7-9-23-22(13-20)27-26-28-25(34)19-6-2-4-17(12-19)15-31-24(33)10-8-21(29-31)18-5-1-3-16(11-18)14-30(23)26/h1-13,32H,14-15H2,(H,27,28,34)
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Assay Description
IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...


US Patent US10064861 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%