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Patent code US10065928

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271461
PNG
(2-(6-((1H-indol-1-yl)sulfonyl)-4-hydroxy-1-methyl-...)
Show SMILES Cn1c2ccc(cc2c(O)c(C(=O)NCC(O)=O)c1=O)S(=O)(=O)n1ccc2ccccc12
Show InChI InChI=1S/C21H17N3O7S/c1-23-16-7-6-13(32(30,31)24-9-8-12-4-2-3-5-15(12)24)10-14(16)19(27)18(21(23)29)20(28)22-11-17(25)26/h2-10,27H,11H2,1H3,(H,22,28)(H,25,26)
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n/an/an/an/a 6.83E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271496
PNG
(2-(7-(2-fluorophenoxy)-4-hydroxy-1-methyl-2-oxo-1,...)
Show SMILES Cn1c2cc(Oc3ccccc3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H15FN2O6/c1-22-13-8-10(28-14-5-3-2-4-12(14)20)6-7-11(13)17(25)16(19(22)27)18(26)21-9-15(23)24/h2-8,25H,9H2,1H3,(H,21,26)(H,23,24)
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n/an/an/an/a 6.02E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271472
PNG
(2-(7-(2,5-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cc(F)ccc3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14F2N2O6/c1-23-13-7-10(29-14-6-9(20)2-5-12(14)21)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 2.26E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271478
PNG
(2-(7-(4-chloro-3-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3ccc(Cl)c(F)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-14-7-10(29-9-3-5-12(20)13(21)6-9)2-4-11(14)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 1.02E+4n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271489
PNG
(2-(4-hydroxy-7-(4-methoxyphenoxy)-1-methyl-2-oxo-1...)
Show SMILES COc1ccc(Oc2ccc3c(O)c(C(=O)NCC(O)=O)c(=O)n(C)c3c2)cc1
Show InChI InChI=1S/C20H18N2O7/c1-22-15-9-13(29-12-5-3-11(28-2)4-6-12)7-8-14(15)18(25)17(20(22)27)19(26)21-10-16(23)24/h3-9,25H,10H2,1-2H3,(H,21,26)(H,23,24)
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n/an/an/an/a 2.95E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271459
PNG
(2-(1-(cyclopropylmethyl)-4-hydroxy-2-oxo-7-phenoxy...)
Show SMILES OC(=O)CNC(=O)c1c(O)c2ccc(Oc3ccccc3)cc2n(CC2CC2)c1=O
Show InChI InChI=1S/C22H20N2O6/c25-18(26)11-23-21(28)19-20(27)16-9-8-15(30-14-4-2-1-3-5-14)10-17(16)24(22(19)29)12-13-6-7-13/h1-5,8-10,13,27H,6-7,11-12H2,(H,23,28)(H,25,26)
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n/an/an/an/a 5.00E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271460
PNG
(2-(4-hydroxy-1-methyl-2-oxo-6-phenoxy-1,2-dihydroq...)
Show SMILES Cn1c2ccc(Oc3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H16N2O6/c1-21-14-8-7-12(27-11-5-3-2-4-6-11)9-13(14)17(24)16(19(21)26)18(25)20-10-15(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
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n/an/an/an/a 4.00E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271468
PNG
(2-(7-(2,4-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3ccc(F)cc3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14F2N2O6/c1-23-13-7-10(29-14-5-2-9(20)6-12(14)21)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 6.92E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271480
PNG
(2-(7-(2-chloro-5-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3cc(F)ccc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-13-7-10(29-14-6-9(21)2-5-12(14)20)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 6.85E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271485
PNG
(2-(7-(2,6-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3c(Cl)cccc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14Cl2N2O6/c1-23-13-7-9(29-17-11(20)3-2-4-12(17)21)5-6-10(13)16(26)15(19(23)28)18(27)22-8-14(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 3.63E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271486
PNG
(2-(7-(3,4-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3ccc(Cl)c(Cl)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14Cl2N2O6/c1-23-14-7-10(29-9-3-5-12(20)13(21)6-9)2-4-11(14)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 2.56E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271490
PNG
(2-(4-hydroxy-7-(3-methoxyphenoxy)-1-methyl-2-oxo-1...)
Show SMILES COc1cccc(Oc2ccc3c(O)c(C(=O)NCC(O)=O)c(=O)n(C)c3c2)c1
Show InChI InChI=1S/C20H18N2O7/c1-22-15-9-13(29-12-5-3-4-11(8-12)28-2)6-7-14(15)18(25)17(20(22)27)19(26)21-10-16(23)24/h3-9,25H,10H2,1-2H3,(H,21,26)(H,23,24)
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n/an/an/an/a 6.26E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271492
PNG
(2-(6-fluoro-4-hydroxy-1-methyl-2-oxo-7-phenoxy-1,2...)
Show SMILES Cn1c2cc(Oc3ccccc3)c(F)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H15FN2O6/c1-22-13-8-14(28-10-5-3-2-4-6-10)12(20)7-11(13)17(25)16(19(22)27)18(26)21-9-15(23)24/h2-8,25H,9H2,1H3,(H,21,26)(H,23,24)
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n/an/an/an/a 4.89E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271473
PNG
(2-(7-(3-chloro-2-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3cccc(Cl)c3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-12-7-9(29-13-4-2-3-11(20)16(13)21)5-6-10(12)17(26)15(19(23)28)18(27)22-8-14(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 3.75E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271475
PNG
(2-(7-(5-chloro-2-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3cc(Cl)ccc3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-13-7-10(29-14-6-9(20)2-5-12(14)21)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 4.18E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271479
PNG
(2-(7-(3-chloro-5-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3cc(F)cc(Cl)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-14-7-11(29-12-5-9(20)4-10(21)6-12)2-3-13(14)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 1.35E+4n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271483
PNG
(2-(7-(2,3-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cccc(Cl)c3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14Cl2N2O6/c1-23-12-7-9(29-13-4-2-3-11(20)16(13)21)5-6-10(12)17(26)15(19(23)28)18(27)22-8-14(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 1.97E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271474
PNG
(2-(7-(4-chloro-2-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3ccc(Cl)cc3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-13-7-10(29-14-5-2-9(20)6-12(14)21)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 5.75E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271481
PNG
(2-(7-(2-chloro-4-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3ccc(F)cc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-13-7-10(29-14-5-2-9(21)6-12(14)20)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 1.51E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271491
PNG
(2-(4-hydroxy-7-(2-methoxyphenoxy)-1-methyl-2-oxo-1...)
Show SMILES COc1ccccc1Oc1ccc2c(O)c(C(=O)NCC(O)=O)c(=O)n(C)c2c1
Show InChI InChI=1S/C20H18N2O7/c1-22-13-9-11(29-15-6-4-3-5-14(15)28-2)7-8-12(13)18(25)17(20(22)27)19(26)21-10-16(23)24/h3-9,25H,10H2,1-2H3,(H,21,26)(H,23,24)
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n/an/an/an/a 8.85E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271463
PNG
(2-(4-hydroxy-1-methyl-6-(naphthalen-2-yloxy)-2-oxo...)
Show SMILES Cn1c2ccc(Oc3ccc4ccccc4c3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C23H18N2O6/c1-25-18-9-8-16(31-15-7-6-13-4-2-3-5-14(13)10-15)11-17(18)21(28)20(23(25)30)22(29)24-12-19(26)27/h2-11,28H,12H2,1H3,(H,24,29)(H,26,27)
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n/an/an/an/a 2.52E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271466
PNG
(2-(7-(4-chlorophenoxy)-4-hydroxy-1-methyl-2-oxo-1,...)
Show SMILES Cn1c2cc(Oc3ccc(Cl)cc3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H15ClN2O6/c1-22-14-8-12(28-11-4-2-10(20)3-5-11)6-7-13(14)17(25)16(19(22)27)18(26)21-9-15(23)24/h2-8,25H,9H2,1H3,(H,21,26)(H,23,24)
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n/an/an/an/a 7.10E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271469
PNG
(2-(7-(2,6-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3c(F)cccc3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14F2N2O6/c1-23-13-7-9(29-17-11(20)3-2-4-12(17)21)5-6-10(13)16(26)15(19(23)28)18(27)22-8-14(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 8.83E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271477
PNG
(2-(7-(2-chloro-3-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3cccc(F)c3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-12-7-9(29-13-4-2-3-11(21)16(13)20)5-6-10(12)17(26)15(19(23)28)18(27)22-8-14(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 9.53E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271498
PNG
(2-(7-(4-fluorophenoxy)-4-hydroxy-1-methyl-2-oxo-1,...)
Show SMILES Cn1c2cc(Oc3ccc(F)cc3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H15FN2O6/c1-22-14-8-12(28-11-4-2-10(20)3-5-11)6-7-13(14)17(25)16(19(22)27)18(26)21-9-15(23)24/h2-8,25H,9H2,1H3,(H,21,26)(H,23,24)
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n/an/an/an/a 3.92E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271462
PNG
(2-(4-hydroxy-1-methyl-7-(naphthalen-2-yloxy)-2-oxo...)
Show SMILES Cn1c2cc(Oc3ccc4ccccc4c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C23H18N2O6/c1-25-18-11-16(31-15-7-6-13-4-2-3-5-14(13)10-15)8-9-17(18)21(28)20(23(25)30)22(29)24-12-19(26)27/h2-11,28H,12H2,1H3,(H,24,29)(H,26,27)
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n/an/an/an/a 1.63E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271465
PNG
(2-(7-(3-chlorophenoxy)-4-hydroxy-1-methyl-2-oxo-1,...)
Show SMILES Cn1c2cc(Oc3cccc(Cl)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H15ClN2O6/c1-22-14-8-12(28-11-4-2-3-10(20)7-11)5-6-13(14)17(25)16(19(22)27)18(26)21-9-15(23)24/h2-8,25H,9H2,1H3,(H,21,26)(H,23,24)
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n/an/an/an/a 4.24E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271467
PNG
(2-(7-(2,3-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cccc(F)c3F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14F2N2O6/c1-23-12-7-9(29-13-4-2-3-11(20)16(13)21)5-6-10(12)17(26)15(19(23)28)18(27)22-8-14(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 1.03E+4n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271476
PNG
(2-(7-(2-chloro-6-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3c(F)cccc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-13-7-9(29-17-11(20)3-2-4-12(17)21)5-6-10(13)16(26)15(19(23)28)18(27)22-8-14(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 9.23E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271482
PNG
(2-(7-(3-chloro-4-fluorophenoxy)-4-hydroxy-1-methyl...)
Show SMILES Cn1c2cc(Oc3ccc(F)c(Cl)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14ClFN2O6/c1-23-14-7-10(29-9-3-5-13(21)12(20)6-9)2-4-11(14)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 1.02E+4n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271495
PNG
(2-(4-hydroxy-1-methyl-2-oxo-7-(pyridin-4-yloxy)-1,...)
Show SMILES Cn1c2cc(Oc3ccncc3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C18H15N3O6/c1-21-13-8-11(27-10-4-6-19-7-5-10)2-3-12(13)16(24)15(18(21)26)17(25)20-9-14(22)23/h2-8,24H,9H2,1H3,(H,20,25)(H,22,23)
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n/an/an/an/a 2.89E+4n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271470
PNG
(2-(7-(3,4-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3ccc(F)c(F)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14F2N2O6/c1-23-14-7-10(29-9-3-5-12(20)13(21)6-9)2-4-11(14)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 3.16E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271484
PNG
(2-(7-(2,4-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3ccc(Cl)cc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14Cl2N2O6/c1-23-13-7-10(29-14-5-2-9(20)6-12(14)21)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
PDB

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n/an/an/an/a 4.15E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271488
PNG
(2-(7-(2,5-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cc(Cl)ccc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14Cl2N2O6/c1-23-13-7-10(29-14-6-9(20)2-5-12(14)21)3-4-11(13)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
PDB

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n/an/an/an/a 2.25E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271494
PNG
(2-(1-(cyclopropylethyl)-4-hydroxy-2-oxo-7-phenoxy-...)
Show SMILES OC(=O)CNC(=O)c1c(O)c2ccc(Oc3ccccc3)cc2n(CCC2CC2)c1=O
Show InChI InChI=1S/C23H22N2O6/c26-19(27)13-24-22(29)20-21(28)17-9-8-16(31-15-4-2-1-3-5-15)12-18(17)25(23(20)30)11-10-14-6-7-14/h1-5,8-9,12,14,28H,6-7,10-11,13H2,(H,24,29)(H,26,27)
PDB

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n/an/an/an/a 3.34E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271497
PNG
(2-(7-(3-fluorophenoxy)-4-hydroxy-1-methyl-2-oxo-1,...)
Show SMILES Cn1c2cc(Oc3cccc(F)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H15FN2O6/c1-22-14-8-12(28-11-4-2-3-10(20)7-11)5-6-13(14)17(25)16(19(22)27)18(26)21-9-15(23)24/h2-8,25H,9H2,1H3,(H,21,26)(H,23,24)
PDB

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n/an/an/an/a 3.61E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271499
PNG
(2-(7-(2-chlorophenoxy)-4-hydroxy-1-methyl-2-oxo-1,...)
Show SMILES Cn1c2cc(Oc3ccccc3Cl)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H15ClN2O6/c1-22-13-8-10(28-14-5-3-2-4-12(14)20)6-7-11(13)17(25)16(19(22)27)18(26)21-9-15(23)24/h2-8,25H,9H2,1H3,(H,21,26)(H,23,24)
PDB

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n/an/an/an/a 6.60E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271458
PNG
(2-(4-hydroxy-1-methyl-2-oxo-7-phenoxy-1,2-dihydroq...)
Show SMILES Cn1c2cc(Oc3ccccc3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H16N2O6/c1-21-14-9-12(27-11-5-3-2-4-6-11)7-8-13(14)17(24)16(19(21)26)18(25)20-10-15(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
PDB

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n/an/an/an/a 5.35E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271464
PNG
(2-(6-(benzhydryl(methyl)carbamoyl)-4-hydroxy-1-met...)
Show SMILES CN(C(c1ccccc1)c1ccccc1)C(=O)c1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C28H25N3O6/c1-30-21-14-13-19(15-20(21)25(34)23(28(30)37)26(35)29-16-22(32)33)27(36)31(2)24(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-15,24,34H,16H2,1-2H3,(H,29,35)(H,32,33)
PDB

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n/an/an/an/a 1.02E+4n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271487
PNG
(2-(7-(3,5-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cc(Cl)cc(Cl)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14Cl2N2O6/c1-23-14-7-11(29-12-5-9(20)4-10(21)6-12)2-3-13(14)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/an/an/a 2.02E+4n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271493
PNG
(2-(4-hydroxy-1-methyl-2-oxo-7-(2-(trifluoromethoxy...)
Show SMILES Cn1c2cc(Oc3ccccc3OC(F)(F)F)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C20H15F3N2O7/c1-25-12-8-10(31-13-4-2-3-5-14(13)32-20(21,22)23)6-7-11(12)17(28)16(19(25)30)18(29)24-9-15(26)27/h2-8,28H,9H2,1H3,(H,24,29)(H,26,27)
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n/an/an/an/a 4.06E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM271471
PNG
(2-(7-(3,5-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Show SMILES Cn1c2cc(Oc3cc(F)cc(F)c3)ccc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C19H14F2N2O6/c1-23-14-7-11(29-12-5-9(20)4-10(21)6-12)2-3-13(14)17(26)16(19(23)28)18(27)22-8-15(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
PDB

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KEGG

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n/an/an/an/a 6.28E+3n/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...


US Patent US10065928 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%