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Patent code US10065948

Compile Data Set for Download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase


(Homo sapiens (Human))
BDBM272075
PNG
((S)-1-(2,6-Difluorophenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1c(F)cccc1F)C(=O)NO
Show InChI InChI=1S/C20H16F3N3O2/c1-11-13(4-2-5-14(11)21)20(19(27)25-28)8-12-10-24-26(17(12)9-20)18-15(22)6-3-7-16(18)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272071
PNG
((S)-1-(2-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C20H17ClFN3O2/c1-12-14(5-4-7-16(12)22)20(19(26)24-27)9-13-11-23-25(18(13)10-20)17-8-3-2-6-15(17)21/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272078
PNG
((S)-1-(2-Chloro-6-fluorophenyl)-5-(3-fluoro-2- met...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1c(F)cccc1Cl)C(=O)NO
Show InChI InChI=1S/C20H16ClF2N3O2/c1-11-13(4-2-6-15(11)22)20(19(27)25-28)8-12-10-24-26(17(12)9-20)18-14(21)5-3-7-16(18)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272074
PNG
((S)-1-(3-Chloro-2-fluorophenyl)-5-(3-fluoro-2- met...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1cccc(Cl)c1F)C(=O)NO
Show InChI InChI=1S/C20H16ClF2N3O2/c1-11-13(4-2-6-15(11)22)20(19(27)25-28)8-12-10-24-26(17(12)9-20)16-7-3-5-14(21)18(16)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272067
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-l-(2-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1F)C(=O)NO
Show InChI InChI=1S/C20H17F2N3O2/c1-12-14(5-4-7-15(12)21)20(19(26)24-27)9-13-11-23-25(18(13)10-20)17-8-3-2-6-16(17)22/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272079
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-1-(2-fluoro-6- met...)
Show SMILES Cc1cccc(F)c1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H19F2N3O2/c1-12-5-3-8-17(23)19(12)26-18-10-21(20(27)25-28,9-14(18)11-24-26)15-6-4-7-16(22)13(15)2/h3-8,11,28H,9-10H2,1-2H3,(H,25,27)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272076
PNG
((S)-1-(2,5-Dimethylphenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1ccc(C)c(c1)-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C22H22FN3O2/c1-13-7-8-14(2)19(9-13)26-20-11-22(21(27)25-28,10-16(20)12-24-26)17-5-4-6-18(23)15(17)3/h4-9,12,28H,10-11H2,1-3H3,(H,25,27)/t22-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272066
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-l-(o- to...)
Show SMILES Cc1ccccc1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H20FN3O2/c1-13-6-3-4-9-18(13)25-19-11-21(20(26)24-27,10-15(19)12-23-25)16-7-5-8-17(22)14(16)2/h3-9,12,27H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272158
PNG
((R)-1-Benzyl-4-(3-fluoro-2-methylphenyl)-N-hydroxy...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2c1cnn2Cc1ccccc1)C(=O)NO
Show InChI InChI=1S/C21H20FN3O2/c1-14-16(8-5-9-18(14)22)21(20(26)24-27)11-10-19-17(21)12-23-25(19)13-15-6-3-2-4-7-15/h2-9,12,27H,10-11,13H2,1H3,(H,24,26)/t21-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272077
PNG
((S)-1-(2,6-Dimethylphenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1cccc(C)c1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C22H22FN3O2/c1-13-6-4-7-14(2)20(13)26-19-11-22(21(27)25-28,10-16(19)12-24-26)17-8-5-9-18(23)15(17)3/h4-9,12,28H,10-11H2,1-3H3,(H,25,27)/t22-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272065
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-phenyl...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1)C(=O)NO
Show InChI InChI=1S/C20H18FN3O2/c1-13-16(8-5-9-17(13)21)20(19(25)23-26)10-14-12-22-24(18(14)11-20)15-6-3-2-4-7-15/h2-9,12,26H,10-11H2,1H3,(H,23,25)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272088
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-(m- to...)
Show SMILES Cc1cccc(c1)-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H20FN3O2/c1-13-5-3-6-16(9-13)25-19-11-21(20(26)24-27,10-15(19)12-23-25)17-7-4-8-18(22)14(17)2/h3-9,12,27H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272081
PNG
((S)-1-(2,4-Difluorophenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccc(F)cc1F)C(=O)NO
Show InChI InChI=1S/C20H16F3N3O2/c1-11-14(3-2-4-15(11)22)20(19(27)25-28)8-12-10-24-26(18(12)9-20)17-6-5-13(21)7-16(17)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272080
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-1-(5-fluoropyridin...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccc(F)cn1)C(=O)NO
Show InChI InChI=1S/C19H16F2N4O2/c1-11-14(3-2-4-15(11)21)19(18(26)24-27)7-12-9-23-25(16(12)8-19)17-6-5-13(20)10-22-17/h2-6,9-10,27H,7-8H2,1H3,(H,24,26)/t19-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272155
PNG
((S)-1-(2-Chloro-4-fluorophenyl)-5-(3-fluoro-2- met...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccc(F)cc1Cl)C(=O)NO
Show InChI InChI=1S/C20H16ClF2N3O2/c1-11-14(3-2-4-16(11)23)20(19(27)25-28)8-12-10-24-26(18(12)9-20)17-6-5-13(22)7-15(17)21/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272082
PNG
((S)-1-Cyclopentyl-5-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(C3CCCC3)c2C1)C(=O)NO
Show InChI InChI=1S/C19H22FN3O2/c1-12-15(7-4-8-16(12)20)19(18(24)22-25)9-13-11-21-23(17(13)10-19)14-5-2-3-6-14/h4,7-8,11,14,25H,2-3,5-6,9-10H2,1H3,(H,22,24)/t19-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272083
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1- (pyra...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1cnccn1)C(=O)NO
Show InChI InChI=1S/C18H16FN5O2/c1-11-13(3-2-4-14(11)19)18(17(25)23-26)7-12-9-22-24(15(12)8-18)16-10-20-5-6-21-16/h2-6,9-10,26H,7-8H2,1H3,(H,23,25)/t18-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272073
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-(p- to...)
Show SMILES Cc1ccc(cc1)-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H20FN3O2/c1-13-6-8-16(9-7-13)25-19-11-21(20(26)24-27,10-15(19)12-23-25)17-4-3-5-18(22)14(17)2/h3-9,12,27H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272133
PNG
((R)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(1- me...)
Show SMILES Cc1c(F)cccc1[C@]1(Cc2nc(sc2C1)-c1ccnn1C)C(=O)NO
Show InChI InChI=1S/C18H17FN4O2S/c1-10-11(4-3-5-12(10)19)18(17(24)22-25)8-13-15(9-18)26-16(21-13)14-6-7-20-23(14)2/h3-7,25H,8-9H2,1-2H3,(H,22,24)/t18-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272086
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-1-(4-fluoro-2- met...)
Show SMILES Cc1cc(F)ccc1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H19F2N3O2/c1-12-8-15(22)6-7-18(12)26-19-10-21(20(27)25-28,9-14(19)11-24-26)16-4-3-5-17(23)13(16)2/h3-8,11,28H,9-10H2,1-2H3,(H,25,27)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272070
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-1-(3-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1cccc(F)c1)C(=O)NO
Show InChI InChI=1S/C20H17F2N3O2/c1-12-16(6-3-7-17(12)22)20(19(26)24-27)9-13-11-23-25(18(13)10-20)15-5-2-4-14(21)8-15/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272157
PNG
((S)-1-Benzyl-5-(3-fluoro-2-methylphenyl)-N-hydroxy...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(Cc3ccccc3)c2C1)C(=O)NO
Show InChI InChI=1S/C21H20FN3O2/c1-14-17(8-5-9-18(14)22)21(20(26)24-27)10-16-12-23-25(19(16)11-21)13-15-6-3-2-4-7-15/h2-9,12,27H,10-11,13H2,1H3,(H,24,26)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272122
PNG
((S)-1-Cyclopropyl-5-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(C3CC3)c2C1)C(=O)NO
Show InChI InChI=1S/C17H18FN3O2/c1-10-13(3-2-4-14(10)18)17(16(22)20-23)7-11-9-19-21(12-5-6-12)15(11)8-17/h2-4,9,12,23H,5-8H2,1H3,(H,20,22)/t17-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272154
PNG
((R)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(5- fl...)
Show SMILES Cc1c(F)cccc1[C@]1(Cc2nc(sc2C1)-c1ccc(F)cn1)C(=O)NO
Show InChI InChI=1S/C19H15F2N3O2S/c1-10-12(3-2-4-13(10)21)19(18(25)24-26)7-15-16(8-19)27-17(23-15)14-6-5-11(20)9-22-14/h2-6,9,26H,7-8H2,1H3,(H,24,25)/t19-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272143
PNG
((R)-5-(3-Fluoro-2-methylphenyl)-3-(4-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2nn(C)c(c2C1)-c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C21H19F2N3O2/c1-12-16(4-3-5-17(12)23)21(20(27)25-28)10-15-18(11-21)24-26(2)19(15)13-6-8-14(22)9-7-13/h3-9,28H,10-11H2,1-2H3,(H,25,27)/t21-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272091
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(3- me...)
Show SMILES Cc1cnccc1-n1cc2C[C@@](Cc2n1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C20H19FN4O2/c1-12-10-22-7-6-18(12)25-11-14-8-20(19(26)24-27,9-17(14)23-25)15-4-3-5-16(21)13(15)2/h3-7,10-11,27H,8-9H2,1-2H3,(H,24,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272069
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-1-(4-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C20H17F2N3O2/c1-12-16(3-2-4-17(12)22)20(19(26)24-27)9-13-11-23-25(18(13)10-20)15-7-5-14(21)6-8-15/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272090
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-(3- me...)
Show SMILES Cc1cnccc1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C20H19FN4O2/c1-12-10-22-7-6-17(12)25-18-9-20(19(26)24-27,8-14(18)11-23-25)15-4-3-5-16(21)13(15)2/h3-7,10-11,27H,8-9H2,1-2H3,(H,24,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272068
PNG
((S)-1-(3-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1cccc(Cl)c1)C(=O)NO
Show InChI InChI=1S/C20H17ClFN3O2/c1-12-16(6-3-7-17(12)22)20(19(26)24-27)9-13-11-23-25(18(13)10-20)15-5-2-4-14(21)8-15/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272092
PNG
((S)-2-(3-Chloropyridin-2-yl)-5-(3-fluoro-2- methyl...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cn(nc2C1)-c1ncccc1Cl)C(=O)NO
Show InChI InChI=1S/C19H16ClFN4O2/c1-11-13(4-2-6-15(11)21)19(18(26)24-27)8-12-10-25(23-16(12)9-19)17-14(20)5-3-7-22-17/h2-7,10,27H,8-9H2,1H3,(H,24,26)/t19-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272117
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1- isopr...)
Show SMILES CC(C)n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C17H20FN3O2/c1-10(2)21-15-8-17(16(22)20-23,7-12(15)9-19-21)13-5-4-6-14(18)11(13)3/h4-6,9-10,23H,7-8H2,1-3H3,(H,20,22)/t17-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272140
PNG
(E1-(abs)-2-(1,5-Dimethyl-1H-pyrazol-4-yl)-5-(3- fl...)
Show SMILES Cc1c(cnn1C)-c1nc2CC(Cc2s1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C19H19FN4O2S/c1-10-13(5-4-6-14(10)20)19(18(25)23-26)7-15-16(8-19)27-17(22-15)12-9-21-24(3)11(12)2/h4-6,9,26H,7-8H2,1-3H3,(H,23,25)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272118
PNG
((R)-4-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-phenyl...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2c1cnn2-c1ccccc1)C(=O)NO
Show InChI InChI=1S/C20H18FN3O2/c1-13-15(8-5-9-17(13)21)20(19(25)23-26)11-10-18-16(20)12-22-24(18)14-6-3-2-4-7-14/h2-9,12,26H,10-11H2,1H3,(H,23,25)/t20-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272089
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(m- to...)
Show SMILES Cc1cccc(c1)-n1cc2C[C@@](Cc2n1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H20FN3O2/c1-13-5-3-6-16(9-13)25-12-15-10-21(20(26)24-27,11-19(15)23-25)17-7-4-8-18(22)14(17)2/h3-9,12,27H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272144
PNG
(E1-(abs)-5-(3-fluoro-2-methylphenyl)-N-hydroxy-3- ...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2snc(c2C1)-c1ccccc1)C(=O)NO
Show InChI InChI=1S/C20H17FN2O2S/c1-12-15(8-5-9-16(12)21)20(19(24)22-25)10-14-17(11-20)26-23-18(14)13-6-3-2-4-7-13/h2-9,25H,10-11H2,1H3,(H,22,24)/t20-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272130
PNG
((R)-5-(3-Fluoro-2-methylphenyl)-2-(4-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@]1(Cc2nc(sc2C1)-c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C20H16F2N2O2S/c1-11-14(3-2-4-15(11)22)20(19(25)24-26)9-16-17(10-20)27-18(23-16)12-5-7-13(21)8-6-12/h2-8,26H,9-10H2,1H3,(H,24,25)/t20-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272136
PNG
((S)-2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2nc(sc12)C1CC1)C(=O)NO
Show InChI InChI=1S/C17H17FN2O2S/c1-9-11(3-2-4-12(9)18)17(16(21)20-22)8-7-13-14(17)23-15(19-13)10-5-6-10/h2-4,10,22H,5-8H2,1H3,(H,20,21)/t17-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272135
PNG
((R)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(5- me...)
Show SMILES COc1ccc(nc1)-c1nc2C[C@](Cc2s1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C20H18FN3O3S/c1-11-13(4-3-5-14(11)21)20(19(25)24-26)8-16-17(9-20)28-18(23-16)15-7-6-12(27-2)10-22-15/h3-7,10,26H,8-9H2,1-2H3,(H,24,25)/t20-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272123
PNG
((R)-1-Cyclopropyl-4-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2c1cnn2C1CC1)C(=O)NO
Show InChI InChI=1S/C17H18FN3O2/c1-10-12(3-2-4-14(10)18)17(16(22)20-23)8-7-15-13(17)9-19-21(15)11-5-6-11/h2-4,9,11,23H,5-8H2,1H3,(H,20,22)/t17-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272113
PNG
((R)-2-(2-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2nc(ncc12)-c1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C21H17ClFN3O2/c1-12-14(6-4-8-17(12)23)21(20(27)26-28)10-9-18-15(21)11-24-19(25-18)13-5-2-3-7-16(13)22/h2-8,11,28H,9-10H2,1H3,(H,26,27)/t21-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272093
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-2-(3-fluoropyridin...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cn(nc2C1)-c1ncccc1F)C(=O)NO
Show InChI InChI=1S/C19H16F2N4O2/c1-11-13(4-2-5-14(11)20)19(18(26)24-27)8-12-10-25(23-16(12)9-19)17-15(21)6-3-7-22-17/h2-7,10,27H,8-9H2,1H3,(H,24,26)/t19-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272084
PNG
((S)-1-(4-(Difluoromethoxy)phenyl)-5-(3-fluoro-2- m...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccc(OC(F)F)cc1)C(=O)NO
Show InChI InChI=1S/C21H18F3N3O3/c1-12-16(3-2-4-17(12)22)21(19(28)26-29)9-13-11-25-27(18(13)10-21)14-5-7-15(8-6-14)30-20(23)24/h2-8,11,20,29H,9-10H2,1H3,(H,26,28)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272146
PNG
(2-(3-Fluoro-2-methylphenyl)-N-hydroxy-2,3-dihydro-...)
Show SMILES Cc1c(F)cccc1C1(Cc2ccccc2C1)C(=O)NO
Show InChI InChI=1S/C17H16FNO2/c1-11-14(7-4-8-15(11)18)17(16(20)19-21)9-12-5-2-3-6-13(12)10-17/h2-8,21H,9-10H2,1H3,(H,19,20)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272072
PNG
((S)-1-(4-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccc(Cl)cc1)C(=O)NO
Show InChI InChI=1S/C20H17ClFN3O2/c1-12-16(3-2-4-17(12)22)20(19(26)24-27)9-13-11-23-25(18(13)10-20)15-7-5-14(21)6-8-15/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272142
PNG
((S)-6-(3-Fluoro-2-methylphenyl)-2-(4-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2nc(sc12)-c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C20H16F2N2O2S/c1-11-14(3-2-4-15(11)22)20(19(25)24-26)10-9-16-17(20)27-18(23-16)12-5-7-13(21)8-6-12/h2-8,26H,9-10H2,1H3,(H,24,25)/t20-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272134
PNG
((R)-2-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(3-fluoro-2...)
Show SMILES Cc1cc(-c2nc3C[C@](Cc3s2)(C(=O)NO)c2cccc(F)c2C)n(C)n1
Show InChI InChI=1S/C19H19FN4O2S/c1-10-7-15(24(3)22-10)17-21-14-8-19(18(25)23-26,9-16(14)27-17)12-5-4-6-13(20)11(12)2/h4-7,26H,8-9H2,1-3H3,(H,23,25)/t19-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272137
PNG
((S)-6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(o- to...)
Show SMILES Cc1ccccc1-c1nc2CC[C@](C(=O)NO)(c2s1)c1cccc(F)c1C
Show InChI InChI=1S/C21H19FN2O2S/c1-12-6-3-4-7-14(12)19-23-17-10-11-21(18(17)27-19,20(25)24-26)15-8-5-9-16(22)13(15)2/h3-9,26H,10-11H2,1-2H3,(H,24,25)/t21-/m1/s1
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n/an/a 143n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272085
PNG
((S)-2-(4-(Difluoromethoxy)phenyl)-5-(3-fluoro-2- m...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cn(nc2C1)-c1ccc(OC(F)F)cc1)C(=O)NO
Show InChI InChI=1S/C21H18F3N3O3/c1-12-16(3-2-4-17(12)22)21(19(28)26-29)9-13-11-27(25-18(13)10-21)14-5-7-15(8-6-14)30-20(23)24/h2-8,11,20,29H,9-10H2,1H3,(H,26,28)/t21-/m0/s1
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n/an/a 147n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272112
PNG
((S)-2-(2-Chlorophenyl)-6-(3-fluoro-2-methylphenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnc(nc2C1)-c1ccccc1Cl)C(=O)NO
Show InChI InChI=1S/C21H17ClFN3O2/c1-12-15(6-4-8-17(12)23)21(20(27)26-28)9-13-11-24-19(25-18(13)10-21)14-5-2-3-7-16(14)22/h2-8,11,28H,9-10H2,1H3,(H,26,27)/t21-/m0/s1
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n/an/a 156n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272116
PNG
((S)-2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnc(nc2C1)C1CC1)C(=O)NO
Show InChI InChI=1S/C18H18FN3O2/c1-10-13(3-2-4-14(10)19)18(17(23)22-24)7-12-9-20-16(11-5-6-11)21-15(12)8-18/h2-4,9,11,24H,5-8H2,1H3,(H,22,23)/t18-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272105
PNG
(6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2- (phenylsu...)
Show SMILES Cc1c(F)cccc1C1(CCc2nc(NS(=O)(=O)c3ccccc3)sc2C1)C(=O)NO
Show InChI InChI=1S/C21H20FN3O4S2/c1-13-15(8-5-9-16(13)22)21(19(26)24-27)11-10-17-18(12-21)30-20(23-17)25-31(28,29)14-6-3-2-4-7-14/h2-9,27H,10-12H2,1H3,(H,23,25)(H,24,26)
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n/an/a 190n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272131
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-2-(4-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2nc(sc2C1)-c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C20H16F2N2O2S/c1-11-14(3-2-4-15(11)22)20(19(25)24-26)9-16-17(10-20)27-18(23-16)12-5-7-13(21)8-6-12/h2-8,26H,9-10H2,1H3,(H,24,25)/t20-/m0/s1
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n/an/a 193n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272125
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-2-(2- fluorop...)
Show SMILES Cc1c(F)cccc1C1(Cc2nc(sc2C1)-c1ccccc1F)C(=O)NO
Show InChI InChI=1S/C20H16F2N2O2S/c1-11-13(6-4-8-14(11)21)20(19(25)24-26)9-16-17(10-20)27-18(23-16)12-5-2-3-7-15(12)22/h2-8,26H,9-10H2,1H3,(H,24,25)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272087
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-2-(4-fluoro-2- met...)
Show SMILES Cc1cc(F)ccc1-n1cc2C[C@@](Cc2n1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H19F2N3O2/c1-12-8-15(22)6-7-19(12)26-11-14-9-21(20(27)25-28,10-18(14)24-26)16-4-3-5-17(23)13(16)2/h3-8,11,28H,9-10H2,1-2H3,(H,25,27)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272140
PNG
(E1-(abs)-2-(1,5-Dimethyl-1H-pyrazol-4-yl)-5-(3- fl...)
Show SMILES Cc1c(cnn1C)-c1nc2CC(Cc2s1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C19H19FN4O2S/c1-10-13(5-4-6-14(10)20)19(18(25)23-26)7-15-16(8-19)27-17(22-15)12-9-21-24(3)11(12)2/h4-6,9,26H,7-8H2,1-3H3,(H,23,25)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272128
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-2-(3- fluorop...)
Show SMILES Cc1c(F)cccc1C1(Cc2nc(sc2C1)-c1cccc(F)c1)C(=O)NO
Show InChI InChI=1S/C20H16F2N2O2S/c1-11-14(6-3-7-15(11)22)20(19(25)24-26)9-16-17(10-20)27-18(23-16)12-4-2-5-13(21)8-12/h2-8,26H,9-10H2,1H3,(H,24,25)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272124
PNG
((S)-6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2- (pyri...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnc(nc2C1)-c1cccnc1)C(=O)NO
Show InChI InChI=1S/C20H17FN4O2/c1-12-15(5-2-6-16(12)21)20(19(26)25-27)8-14-11-23-18(24-17(14)9-20)13-4-3-7-22-10-13/h2-7,10-11,27H,8-9H2,1H3,(H,25,26)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272114
PNG
((R)-2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@]1(Cc2cnc(nc2C1)C1CC1)C(=O)NO
Show InChI InChI=1S/C18H18FN3O2/c1-10-13(3-2-4-14(10)19)18(17(23)22-24)7-12-9-20-16(11-5-6-11)21-15(12)8-18/h2-4,9,11,24H,5-8H2,1H3,(H,22,23)/t18-/m1/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272132
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(1- me...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2nc(sc2C1)-c1ccnn1C)C(=O)NO
Show InChI InChI=1S/C18H17FN4O2S/c1-10-11(4-3-5-12(10)19)18(17(24)22-25)8-13-15(9-18)26-16(21-13)14-6-7-20-23(14)2/h3-7,25H,8-9H2,1-2H3,(H,22,24)/t18-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272115
PNG
((S)-2-Cyclopropyl-5-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@]1(CCc2nc(ccc12)C1CC1)C(=O)NO
Show InChI InChI=1S/C19H19FN2O2/c1-11-13(3-2-4-15(11)20)19(18(23)22-24)10-9-17-14(19)7-8-16(21-17)12-5-6-12/h2-4,7-8,12,24H,5-6,9-10H2,1H3,(H,22,23)/t19-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272138
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-2-(4-fluoro-2...)
Show SMILES Cc1cc(F)ccc1-c1nc2CC(Cc2s1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H18F2N2O2S/c1-11-8-13(22)6-7-14(11)19-24-17-9-21(20(26)25-27,10-18(17)28-19)15-4-3-5-16(23)12(15)2/h3-8,27H,9-10H2,1-2H3,(H,25,26)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272156
PNG
((S)-2-(4,6-Dimethylpyrimidin-2-yl)-5-(3-fluoro-2- ...)
Show SMILES Cc1cc(C)nc(n1)-n1cc2C[C@@](Cc2n1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C20H20FN5O2/c1-11-7-12(2)23-19(22-11)26-10-14-8-20(18(27)25-28,9-17(14)24-26)15-5-4-6-16(21)13(15)3/h4-7,10,28H,8-9H2,1-3H3,(H,25,27)/t20-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272119
PNG
((S)-6-(3-fluoro-2-methylphenyl)-2-(4-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnc(nc2C1)-c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C21H17F2N3O2/c1-12-16(3-2-4-17(12)23)21(20(27)26-28)9-14-11-24-19(25-18(14)10-21)13-5-7-15(22)8-6-13/h2-8,11,28H,9-10H2,1H3,(H,26,27)/t21-/m0/s1
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272125
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-2-(2- fluorop...)
Show SMILES Cc1c(F)cccc1C1(Cc2nc(sc2C1)-c1ccccc1F)C(=O)NO
Show InChI InChI=1S/C20H16F2N2O2S/c1-11-13(6-4-8-14(11)21)20(19(25)24-26)9-16-17(10-20)27-18(23-16)12-5-2-3-7-15(12)22/h2-8,26H,9-10H2,1H3,(H,24,25)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272148
PNG
(E1-(abs)-6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2- ...)
Show SMILES Cc1c(F)cccc1C1(CCc2cn(CC(F)(F)F)nc2CC1)C(=O)NO
Show InChI InChI=1S/C18H19F4N3O2/c1-11-13(3-2-4-14(11)19)17(16(26)24-27)7-5-12-9-25(10-18(20,21)22)23-15(12)6-8-17/h2-4,9,27H,5-8,10H2,1H3,(H,24,26)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272127
PNG
(5-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(3- (trifl...)
Show SMILES Cc1c(F)cccc1C1(Cc2nc(Cc3cccc(c3)C(F)(F)F)sc2C1)C(=O)NO
Show InChI InChI=1S/C22H18F4N2O2S/c1-12-15(6-3-7-16(12)23)21(20(29)28-30)10-17-18(11-21)31-19(27-17)9-13-4-2-5-14(8-13)22(24,25)26/h2-8,30H,9-11H2,1H3,(H,28,29)
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CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272128
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-2-(3- fluorop...)
Show SMILES Cc1c(F)cccc1C1(Cc2nc(sc2C1)-c1cccc(F)c1)C(=O)NO
Show InChI InChI=1S/C20H16F2N2O2S/c1-11-14(6-3-7-15(11)22)20(19(25)24-26)9-16-17(10-20)27-18(23-16)12-4-2-5-13(21)8-12/h2-8,26H,9-10H2,1H3,(H,24,25)
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n/an/a 530n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272100
PNG
(5-(3-Fluoro-2-methylphenyl)-1-(4-fluorobenzyl)-N- ...)
Show SMILES Cc1c(F)cccc1C1(CCc2nn(Cc3ccc(F)cc3)cc2C1)C(=O)NO
Show InChI InChI=1S/C22H21F2N3O2/c1-14-18(3-2-4-19(14)24)22(21(28)26-29)10-9-20-16(11-22)13-27(25-20)12-15-5-7-17(23)8-6-15/h2-8,13,29H,9-12H2,1H3,(H,26,28)
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n/an/a 600n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272160
PNG
((R)-4-(3-fluoro-2-methylphenyl)-2-(2- flurobenzyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2nn(Cc3ccccc3F)cc12)C(=O)NO
Show InChI InChI=1S/C21H19F2N3O2/c1-13-15(6-4-8-17(13)22)21(20(27)25-28)10-9-19-16(21)12-26(24-19)11-14-5-2-3-7-18(14)23/h2-8,12,28H,9-11H2,1H3,(H,25,27)/t21-/m1/s1
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n/an/a 710n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272097
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-2-(2- fluorop...)
Show SMILES Cc1c(F)cccc1C1(CCc2nn(cc2C1)-c1ccccc1F)C(=O)NO
Show InChI InChI=1S/C21H19F2N3O2/c1-13-15(5-4-7-16(13)22)21(20(27)25-28)10-9-18-14(11-21)12-26(24-18)19-8-3-2-6-17(19)23/h2-8,12,28H,9-11H2,1H3,(H,25,27)
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n/an/a 710n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272106
PNG
(2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- hydro...)
Show SMILES Cc1c(F)cccc1C1(CCc2nc(sc2C1)C1CC1)C(=O)NO
Show InChI InChI=1S/C18H19FN2O2S/c1-10-12(3-2-4-13(10)19)18(17(22)21-23)8-7-14-15(9-18)24-16(20-14)11-5-6-11/h2-4,11,23H,5-9H2,1H3,(H,21,22)
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n/an/a 770n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272138
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-2-(4-fluoro-2...)
Show SMILES Cc1cc(F)ccc1-c1nc2CC(Cc2s1)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C21H18F2N2O2S/c1-11-8-13(22)6-7-14(11)19-24-17-9-21(20(26)25-27,10-18(17)28-19)15-4-3-5-16(23)12(15)2/h3-8,27H,9-10H2,1-2H3,(H,25,26)
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n/an/a 780n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272148
PNG
(E1-(abs)-6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2- ...)
Show SMILES Cc1c(F)cccc1C1(CCc2cn(CC(F)(F)F)nc2CC1)C(=O)NO
Show InChI InChI=1S/C18H19F4N3O2/c1-11-13(3-2-4-14(11)19)17(16(26)24-27)7-5-12-9-25(10-18(20,21)22)23-15(12)6-8-17/h2-4,9,27H,5-8,10H2,1H3,(H,24,26)
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n/an/a 790n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272095
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1- ...)
Show SMILES Cc1c(F)cccc1C1(CCc2c(C1)cnn2-c1ccccc1)C(=O)NO
Show InChI InChI=1S/C21H20FN3O2/c1-14-17(8-5-9-18(14)22)21(20(26)24-27)11-10-19-15(12-21)13-23-25(19)16-6-3-2-4-7-16/h2-9,13,27H,10-12H2,1H3,(H,24,26)
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n/an/a 820n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272159
PNG
((R)-2-Benzyl-4-(3-fluoro-2-methylphenyl)-N-hydroxy...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2nn(Cc3ccccc3)cc12)C(=O)NO
Show InChI InChI=1S/C21H20FN3O2/c1-14-16(8-5-9-18(14)22)21(20(26)24-27)11-10-19-17(21)13-25(23-19)12-15-6-3-2-4-7-15/h2-9,13,27H,10-12H2,1H3,(H,24,26)/t21-/m1/s1
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n/an/a 820n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272120
PNG
((S)-6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2- (trif...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnc(nc2C1)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C16H13F4N3O2/c1-8-10(3-2-4-11(8)17)15(14(24)23-25)5-9-7-21-13(16(18,19)20)22-12(9)6-15/h2-4,7,25H,5-6H2,1H3,(H,23,24)/t15-/m0/s1
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n/an/a 880n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272094
PNG
((R)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-phenyl...)
Show SMILES Cc1c(F)cccc1[C@]1(Cc2cnn(c2C1)-c1ccccc1)C(=O)NO
Show InChI InChI=1S/C20H18FN3O2/c1-13-16(8-5-9-17(13)21)20(19(25)23-26)10-14-12-22-24(18(14)11-20)15-6-3-2-4-7-15/h2-9,12,26H,10-11H2,1H3,(H,23,25)/t20-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272108
PNG
(6-(3-Fluoro-2-methylphenyl)-N-hydroxy-4,5,6,7- tet...)
Show SMILES Cc1c(F)cccc1C1(CCc2ncsc2C1)C(=O)NO
Show InChI InChI=1S/C15H15FN2O2S/c1-9-10(3-2-4-11(9)16)15(14(19)18-20)6-5-12-13(7-15)21-8-17-12/h2-4,8,20H,5-7H2,1H3,(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272101
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1- ...)
Show SMILES Cc1ccccc1-n1ncc2CC(CCc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C22H22FN3O2/c1-14-6-3-4-9-19(14)26-20-10-11-22(21(27)25-28,12-16(20)13-24-26)17-7-5-8-18(23)15(17)2/h3-9,13,28H,10-12H2,1-2H3,(H,25,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272147
PNG
(2-Cyclopropyl-7-(3-fluoro-2-methylphenyl)-N- hydro...)
Show SMILES Cc1c(F)cccc1C1(CCc2cnc(nc2CC1)C1CC1)C(=O)NO
Show InChI InChI=1S/C20H22FN3O2/c1-12-15(3-2-4-16(12)21)20(19(25)24-26)9-7-14-11-22-18(13-5-6-13)23-17(14)8-10-20/h2-4,11,13,26H,5-10H2,1H3,(H,24,25)
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n/an/a 1.30E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272110
PNG
(2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- hydro...)
Show SMILES Cc1c(F)cccc1C1(CCc2nc(ncc2C1)C1CC1)C(=O)NO
Show InChI InChI=1S/C19H20FN3O2/c1-11-14(3-2-4-15(11)20)19(18(24)23-25)8-7-16-13(9-19)10-21-17(22-16)12-5-6-12/h2-4,10,12,25H,5-9H2,1H3,(H,23,24)
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n/an/a 1.60E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272104
PNG
(2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- hydro...)
Show SMILES Cc1c(F)cccc1C1(CCc2nc([nH]c(=O)c2C1)C1CC1)C(=O)NO
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n/an/a 1.60E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272099
PNG
(5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-(2,2,2- tr...)
Show SMILES Cc1c(F)cccc1C1(CCc2nn(CC(F)(F)F)cc2C1)C(=O)NO
Show InChI InChI=1S/C17H17F4N3O2/c1-10-12(3-2-4-13(10)18)16(15(25)23-26)6-5-14-11(7-16)8-24(22-14)9-17(19,20)21/h2-4,8,26H,5-7,9H2,1H3,(H,23,25)
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n/an/a 1.70E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272107
PNG
(6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-(pyrimidin...)
Show SMILES Cc1c(F)cccc1C1(CCc2nc(sc2C1)-c1cncnc1)C(=O)NO
Show InChI InChI=1S/C19H17FN4O2S/c1-11-13(3-2-4-14(11)20)19(18(25)24-26)6-5-15-16(7-19)27-17(23-15)12-8-21-10-22-9-12/h2-4,8-10,26H,5-7H2,1H3,(H,24,25)
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n/an/a 1.90E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272111
PNG
(6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2-phenyl- 5,...)
Show SMILES Cc1c(F)cccc1C1(CCc2nc(ncc2C1)-c1ccccc1)C(=O)NO
Show InChI InChI=1S/C22H20FN3O2/c1-14-17(8-5-9-18(14)23)22(21(27)26-28)11-10-19-16(12-22)13-24-20(25-19)15-6-3-2-4-7-15/h2-9,13,28H,10-12H2,1H3,(H,26,27)
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n/an/a 3.20E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272109
PNG
(6-(3-Fluoro-2-methylphenyl)-N-hydroxy-5,6,7,8- tet...)
Show SMILES Cc1c(F)cccc1C1(CCc2ncncc2C1)C(=O)NO
Show InChI InChI=1S/C16H16FN3O2/c1-10-12(3-2-4-13(10)17)16(15(21)20-22)6-5-14-11(7-16)8-18-9-19-14/h2-4,8-9,22H,5-7H2,1H3,(H,20,21)
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n/an/a 3.70E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272103
PNG
(3-Cyclopropyl-5-(3-fluoro-2-methylphenyl)-N- hydro...)
Show SMILES Cc1c(F)cccc1C1(CCc2nn(CC(F)(F)F)c(C3CC3)c2C1)C(=O)NO
Show InChI InChI=1S/C20H21F4N3O2/c1-11-14(3-2-4-15(11)21)19(18(28)26-29)8-7-16-13(9-19)17(12-5-6-12)27(25-16)10-20(22,23)24/h2-4,12,29H,5-10H2,1H3,(H,26,28)
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n/an/a 4.40E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272151
PNG
(E1-(abs)-N-Hydroxy-1-phenyl-2,3-dihydro-1H-indene-...)
Show SMILES ONC(=O)[C@@]1(CCc2ccccc12)c1ccccc1
Show InChI InChI=1S/C16H15NO2/c18-15(17-19)16(13-7-2-1-3-8-13)11-10-12-6-4-5-9-14(12)16/h1-9,19H,10-11H2,(H,17,18)/t16-/m0/s1
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n/an/a 5.67E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272101
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1- ...)
Show SMILES Cc1ccccc1-n1ncc2CC(CCc12)(C(=O)NO)c1cccc(F)c1C
Show InChI InChI=1S/C22H22FN3O2/c1-14-6-3-4-9-19(14)26-20-10-11-22(21(27)25-28,12-16(20)13-24-26)17-7-5-8-18(23)15(17)2/h3-9,13,28H,10-12H2,1-2H3,(H,25,27)
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n/an/a 7.90E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272150
PNG
(N-Hydroxy-6-phenyl-2-(2,2,2-trifluoroethyl)- 2,4,5...)
Show SMILES ONC(=O)C1(CCc2cn(CC(F)(F)F)nc2CC1)c1ccccc1
Show InChI InChI=1S/C17H18F3N3O2/c18-17(19,20)11-23-10-12-6-8-16(15(24)22-25,9-7-14(12)21-23)13-4-2-1-3-5-13/h1-5,10,25H,6-9,11H2,(H,22,24)
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n/an/a 8.20E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272145
PNG
(E2-(abs)-5-(3-fluoro-2-methylphenyl)-N-hydroxy-3- ...)
Show SMILES Cc1c(F)cccc1[C@]1(Cc2snc(c2C1)-c1ccccc1)C(=O)NO
Show InChI InChI=1S/C20H17FN2O2S/c1-12-15(8-5-9-16(12)21)20(19(24)22-25)10-14-17(11-20)26-23-18(14)13-6-3-2-4-7-13/h2-9,25H,10-11H2,1H3,(H,22,24)/t20-/m0/s1
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n/an/a 9.70E+3n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272153
PNG
(N-Hydroxy-2-phenyl-2,3-dihydro-1H-indene-2- carbox...)
Show SMILES ONC(=O)C1(Cc2ccccc2C1)c1ccccc1
Show InChI InChI=1S/C16H15NO2/c18-15(17-19)16(14-8-2-1-3-9-14)10-12-6-4-5-7-13(12)11-16/h1-9,19H,10-11H2,(H,17,18)
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n/an/a 1.53E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272095
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1- ...)
Show SMILES Cc1c(F)cccc1C1(CCc2c(C1)cnn2-c1ccccc1)C(=O)NO
Show InChI InChI=1S/C21H20FN3O2/c1-14-17(8-5-9-18(14)22)21(20(26)24-27)11-10-19-15(12-21)13-23-25(19)16-6-3-2-4-7-16/h2-9,13,27H,10-12H2,1H3,(H,24,26)
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n/an/a 1.73E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272121
PNG
((R)-2-Cyclopropyl-5-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@]1(CCc2nc(ncc12)C1CC1)C(=O)NO
Show InChI InChI=1S/C18H18FN3O2/c1-10-12(3-2-4-14(10)19)18(17(23)22-24)8-7-15-13(18)9-20-16(21-15)11-5-6-11/h2-4,9,11,24H,5-8H2,1H3,(H,22,23)/t18-/m0/s1
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n/an/a 1.94E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272097
PNG
(E1-(abs)-5-(3-Fluoro-2-methylphenyl)-2-(2- fluorop...)
Show SMILES Cc1c(F)cccc1C1(CCc2nn(cc2C1)-c1ccccc1F)C(=O)NO
Show InChI InChI=1S/C21H19F2N3O2/c1-13-15(5-4-7-16(13)22)21(20(27)25-28)10-9-18-14(11-21)12-26(24-18)19-8-3-2-6-17(19)23/h2-8,12,28H,9-11H2,1H3,(H,25,27)
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n/an/a 1.98E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM272152
PNG
(E2-(abs)-N-hydroxy-1-phenyl-2,3-dihydro-1H-indene-...)
Show SMILES ONC(=O)[C@]1(CCc2ccccc12)c1ccccc1
Show InChI InChI=1S/C16H15NO2/c18-15(17-19)16(13-7-2-1-3-8-13)11-10-12-6-4-5-9-14(12)16/h1-9,19H,10-11H2,(H,17,18)/t16-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%