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Patent code US10065963

Compile Data Set for Download or QSAR

Found 620 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272572
PNG
(US10065963, Compound 32b)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/m1/s1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272573
PNG
(US10065963, 32c)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/m0/s1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272571
PNG
(US10065963, Compound 32a)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11+/m1/s1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272574
PNG
(US10065963, Compound 32d)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11+/m0/s1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272699
PNG
(US10065963, Example 102)
Show SMILES COC(=O)C1CCN(C1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272704
PNG
(US10065963, Example 106)
Show SMILES CCOC(=O)C1CCN(CC1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272719
PNG
(2-Amino-N-[1-(8-chloro-3-methyl-5-pyridin-3- ylimi...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cnc(C)n2c1-c1cccnc1
Show InChI InChI=1S/C22H19ClN8O/c1-12(28-22(32)18-20(24)29-30-8-4-7-26-21(18)30)15-9-16(23)17-11-27-13(2)31(17)19(15)14-5-3-6-25-10-14/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272733
PNG
(2-Amino-N-{1-[8-chloro-5-(5-methoxypyridin- 3-yl)i...)
Show SMILES COc1cncc(c1)-c1c(cc(Cl)c2cncn12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H19ClN8O2/c1-12(28-22(32)18-20(24)29-31-5-3-4-27-21(18)31)15-7-16(23)17-10-26-11-30(17)19(15)13-6-14(33-2)9-25-8-13/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272735
PNG
(2-Amino-N-(1-{8-chloro-5-[4- (methylsulfonyl)pheny...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1ccc(nc1)S(C)(=O)=O
Show InChI InChI=1S/C22H19ClN8O3S/c1-12(28-22(32)18-20(24)29-31-7-3-6-26-21(18)31)14-8-15(23)16-10-25-11-30(16)19(14)13-4-5-17(27-9-13)35(2,33)34/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272738
PNG
(US10065963, Example 139)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cn[nH]c1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272739
PNG
(US10065963, Example 140)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cnn(C)c1
Show InChI InChI=1S/C20H18ClN9O/c1-11(26-20(31)16-18(22)27-30-5-3-4-24-19(16)30)13-6-14(21)15-8-23-10-29(15)17(13)12-7-25-28(2)9-12/h3-11H,1-2H3,(H2,22,27)(H,26,31)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272743
PNG
(2-Amino-N-{1-[8-chloro-5-(3- methoxypyrrolidin-1-y...)
Show SMILES COC1CCN(C1)c1c(cc(Cl)c2cncn12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H23ClN8O2/c1-12(26-20(31)17-18(23)27-30-6-3-5-25-19(17)30)14-8-15(22)16-9-24-11-29(16)21(14)28-7-4-13(10-28)32-2/h3,5-6,8-9,11-13H,4,7,10H2,1-2H3,(H2,23,27)(H,26,31)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272750
PNG
(2-Amino-N-{1-[8-chloro-5-(1,1-dioxido-1,4- thiazep...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCCS(=O)(=O)CC1
Show InChI InChI=1S/C21H23ClN8O3S/c1-13(26-20(31)17-18(23)27-30-6-2-4-25-19(17)30)14-10-15(22)16-11-24-12-29(16)21(14)28-5-3-8-34(32,33)9-7-28/h2,4,6,10-13H,3,5,7-9H2,1H3,(H2,23,27)(H,26,31)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272760
PNG
(US10065963, Example 160)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)ncn2c1N1CCNS(=O)(=O)CC1
Show InChI InChI=1S/C20H21Cl2N9O3S/c1-11(27-19(32)14-17(23)28-31-5-2-3-24-18(14)31)12-9-13(21)15-16(22)25-10-30(15)20(12)29-6-4-26-35(33,34)8-7-29/h2-3,5,9-11,26H,4,6-8H2,1H3,(H2,23,28)(H,27,32)/t11-/m0/s1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246867
PNG
(4-[(4-{3-cyano-2-[3- (7H-pyrrolo[2,3- d]pyrimidin-...)
Show SMILES Fc1cc(ccc1C(=O)N1CCN(CC(CC#N)n2ccc(c2)-c2ncnc3[nH]ccc23)CC1)C#N
Show InChI InChI=1S/C26H23FN8O/c27-23-13-18(14-29)1-2-21(23)26(36)34-11-9-33(10-12-34)16-20(3-6-28)35-8-5-19(15-35)24-22-4-7-30-25(22)32-17-31-24/h1-2,4-5,7-8,13,15,17,20H,3,9-12,16H2,(H,30,31,32)
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Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246874
PNG
(US10053465, 13 | US10065963, Compound 13 | {trans-...)
Show SMILES OC[C@H]1CCCN1Cc1cc(OC2CCN(CC2)[C@H]2C[C@@](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C32H36F3N9O2/c33-32(34,35)27-12-21(17-43-9-1-2-23(43)19-45)13-28(41-27)46-25-4-10-42(11-5-25)24-14-31(15-24,6-7-36)44-18-22(16-40-44)29-26-3-8-37-30(26)39-20-38-29/h3,8,12-13,16,18,20,23-25,45H,1-2,4-6,9-11,14-15,17,19H2,(H,37,38,39)/t23-,24-,31-/m1/s1
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Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246881
PNG
(US10053465, 20 | US10065963, Compound 20 | {1-(cis...)
Show SMILES CC(C)(O)c1cc(O[C@H]2CC[C@H](CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C29H31F3N8O2/c1-27(2,41)19-11-23(29(30,31)32)38-24(12-19)42-21-5-3-20(4-6-21)39-15-28(16-39,8-9-33)40-14-18(13-37-40)25-22-7-10-34-26(22)36-17-35-25/h7,10-14,17,20-21,41H,3-6,8,15-16H2,1-2H3,(H,34,35,36)/t20-,21+
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Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM246883
PNG
(US10053465, 22 | US10065963, Compound 22 | {1-(cis...)
Show SMILES O[C@H]1CCN(Cc2cc(O[C@H]3CC[C@H](CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
Show InChI InChI=1S/C31H34F3N9O2/c32-31(33,34)26-11-20(14-41-10-6-23(44)16-41)12-27(40-26)45-24-3-1-22(2-4-24)42-17-30(18-42,7-8-35)43-15-21(13-39-43)28-25-5-9-36-29(25)38-19-37-28/h5,9,11-13,15,19,22-24,44H,1-4,6-7,10,14,16-18H2,(H,36,37,38)/t22-,23-,24+/m0/s1
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Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246892
PNG
(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-16-20(23)25-10-26-21(16)29(27-11)12(2)14-7-15(22)18(24-3)17(19(14)31-4)13-8-28(9-13)5-6-30/h7,10,12-13,30H,5-6,8-9H2,1-2,4H3,(H2,23,25,26)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272777
PNG
(US10065963, Example 177)
Show SMILES CC1CN(CCS1(=O)=O)c1c(cc(Cl)c2c(ncn12)C#N)C(NC(=O)c1c(N)nn2cccnc12)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N9O3S/c1-11-9-33(5-6-39(11,37)38)21-12(7-13(23)16-14(8-27)30-10-34(16)21)17(22(24,25)26)31-20(36)15-18(28)32-35-4-2-3-29-19(15)35/h2-4,7,10-11,17H,5-6,9H2,1H3,(H2,28,32)(H,31,36)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272778
PNG
(US10065963, Example 178)
Show SMILES CCCC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C22H25ClN8O3S/c1-2-4-16(27-21(32)18-19(24)28-31-6-3-5-26-20(18)31)14-11-15(23)17-12-25-13-30(17)22(14)29-7-9-35(33,34)10-8-29/h3,5-6,11-13,16H,2,4,7-10H2,1H3,(H2,24,28)(H,27,32)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272781
PNG
(US10065963, Example 181)
Show SMILES CC(C)C(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C22H25ClN8O3S/c1-13(2)18(27-21(32)17-19(24)28-31-5-3-4-26-20(17)31)14-10-15(23)16-11-25-12-30(16)22(14)29-6-8-35(33,34)9-7-29/h3-5,10-13,18H,6-9H2,1-2H3,(H2,24,28)(H,27,32)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272607
PNG
(US10065963, Example 23)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Br)n[nH]c2c1-c1ccccc1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272608
PNG
(US10065963, Example 24)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(C)n[nH]c2c1-c1ccccc1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272611
PNG
(US10065963, Example 27 | US10065963, Example 28)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1ccccc1
Show InChI InChI=1S/C22H18ClN7O/c1-13(27-22(31)18-20(24)28-30-9-5-8-26-21(18)30)15-10-16(23)17-11-25-12-29(17)19(15)14-6-3-2-4-7-14/h2-13H,1H3,(H2,24,28)(H,27,31)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272613
PNG
(US10065963, Example 29)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(C)c2cnc(C)n2c1-c1cccc(F)c1
Show InChI InChI=1S/C24H22FN7O/c1-13-10-18(14(2)29-24(33)20-22(26)30-31-9-5-8-27-23(20)31)21(16-6-4-7-17(25)11-16)32-15(3)28-12-19(13)32/h4-12,14H,1-3H3,(H2,26,30)(H,29,33)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272623
PNG
(2-Amino-N-(1-[8-chloro-5-(1- oxidothiomorpholin-4-...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCS(=O)CC1
Show InChI InChI=1S/C20H21ClN8O2S/c1-12(25-19(30)16-17(22)26-29-4-2-3-24-18(16)29)13-9-14(21)15-10-23-11-28(15)20(13)27-5-7-32(31)8-6-27/h2-4,9-12H,5-8H2,1H3,(H2,22,26)(H,25,30)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272628
PNG
(US10065963, Example 41)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2ccc(nc12)-c1cncc(OC)c1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272628
PNG
(US10065963, Example 41)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2ccc(nc12)-c1cncc(OC)c1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272630
PNG
(US10065963, Example 43)
Show SMILES CCOc1c(cc(Cl)c2c(Cl)n[nH]c12)C(C)NC(=O)c1c(N)nn2ccc(nc12)-c1cncc(OC)c1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272632
PNG
(US10065963, Example 45)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nc2ccc(Cl)nn12
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272635
PNG
(US10065963, Example 48)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nc2ccc(nn12)-c1cncc(CO)c1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272635
PNG
(US10065963, Example 48)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nc2ccc(nn12)-c1cncc(CO)c1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272636
PNG
(US10065963, Example 49)
Show SMILES CCOc1c(cc(Cl)c2c(Cl)n[nH]c12)C(C)NC(=O)c1c(N)nc2ccc(nn12)-c1cncc(CO)c1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272636
PNG
(US10065963, Example 49)
Show SMILES CCOc1c(cc(Cl)c2c(Cl)n[nH]c12)C(C)NC(=O)c1c(N)nc2ccc(nn12)-c1cncc(CO)c1
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272637
PNG
(US10065963, Example 50)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2ccc(nc12)-c1cccnc1
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272639
PNG
(US10065963, Example 52)
Show SMILES CCOc1c(cc(Cl)c2c(Br)n[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272643
PNG
(US10065963, Example 56)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2ccnn2c1N1CCC(CC1)C#N
Show InChI InChI=1S/C22H22ClN9O/c1-13(28-21(33)18-19(25)29-31-8-2-6-26-20(18)31)15-11-16(23)17-3-7-27-32(17)22(15)30-9-4-14(12-24)5-10-30/h2-3,6-8,11,13-14H,4-5,9-10H2,1H3,(H2,25,29)(H,28,33)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272643
PNG
(US10065963, Example 56)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2ccnn2c1N1CCC(CC1)C#N
Show InChI InChI=1S/C22H22ClN9O/c1-13(28-21(33)18-19(25)29-31-8-2-6-26-20(18)31)15-11-16(23)17-3-7-27-32(17)22(15)30-9-4-14(12-24)5-10-30/h2-3,6-8,11,13-14H,4-5,9-10H2,1H3,(H2,25,29)(H,28,33)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272659
PNG
(2-Amino-N-(1-{8-chloro-5-[(2S)-2-methylpyrrolidin-...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCC[C@@H]1C
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272663
PNG
(2-Amino-N-{1-[8-chloro-5-(3-fluoropiperidin-1- yl)...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCC[C@H](F)C1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272668
PNG
(2-Amino-N-{1-[8-chloro-5-(3-hydroxy-3-methylpiperi...)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCCC(C)(O)C1
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272681
PNG
(US10065963, Example 86)
Show SMILES CCOc1c(cc(Cl)c2c(n[nH]c12)C#N)C(C)NC(=O)c1c(N)nn2cccnc12
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272683
PNG
(2-Amino-N-(1-(8-chloro-5-(4-cyano-4-methylpiperidi...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCC(C)(CC1)C#N
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272690
PNG
(2-Amino-N-{1-[4-chloro-7-(1,1- dioxidothiomorpholi...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCS(=O)(=O)CC1
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272691
PNG
(US10065963, Example 95)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CC[C@@H](C1)NC(C)=O
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272710
PNG
(US10065963, Example 112A)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)n[nH]c2c1N1CCS(=O)(=O)C(C)C1
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272711
PNG
(US10065963, Example 112B)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)n[nH]c2c1N1CCS(=O)(=O)C(C)C1
PDB
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272719
PNG
(2-Amino-N-[1-(8-chloro-3-methyl-5-pyridin-3- ylimi...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cnc(C)n2c1-c1cccnc1
Show InChI InChI=1S/C22H19ClN8O/c1-12(28-22(32)18-20(24)29-30-8-4-7-26-21(18)30)15-9-16(23)17-11-27-13(2)31(17)19(15)14-5-3-6-25-10-14/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272720
PNG
(2-Amino-N-[1-(8-chloro-3-methyl-5- phenylimidazo[1...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cnc(C)n2c1-c1ccccc1
Show InChI InChI=1S/C23H20ClN7O/c1-13(28-23(32)19-21(25)29-30-10-6-9-26-22(19)30)16-11-17(24)18-12-27-14(2)31(18)20(16)15-7-4-3-5-8-15/h3-13H,1-2H3,(H2,25,29)(H,28,32)
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Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%