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Patent code US10065972

Compile Data Set for Download or QSAR
Found 193 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273135
PNG
((R)-N-benzyl-1-{5-[difluoro(phenyl)methyl]-7-oxo-6...)
Show SMILES FC(F)(c1ccccc1)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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n/an/a 4n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273091
PNG
((R)-N-benzyl-1-[6-methyl-7-oxo-5-(tetrahydro-2H-py...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C1CCOCC1
Show InChI InChI=1S/C23H27N5O3S/c1-27-19(16-9-12-31-13-10-16)26-21-18(22(27)30)25-23(32-21)28-11-5-8-17(28)20(29)24-14-15-6-3-2-4-7-15/h2-4,6-7,16-17H,5,8-14H2,1H3,(H,24,29)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273115
PNG
((R)-N-benzyl-1-[6-methyl-7-oxo-5-(piperidin-1-yl)-...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)N1CCCCC1
Show InChI InChI=1S/C23H28N6O2S/c1-27-21(31)18-20(26-22(27)28-12-6-3-7-13-28)32-23(25-18)29-14-8-11-17(29)19(30)24-15-16-9-4-2-5-10-16/h2,4-5,9-10,17H,3,6-8,11-15H2,1H3,(H,24,30)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273041
PNG
((R)-2-[5-(3-methyl-[1,2,4]oxadiazol-5-yl)-7-oxo-6,...)
Show SMILES Cc1noc(n1)-c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273079
PNG
((R)-N-benzyl-1-[6-(2,2-difluoroethyl)-5-(3-methyl-...)
Show SMILES Cc1noc(n1)-c1nc2sc(nc2c(=O)n1CC(F)F)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H21F2N7O3S/c1-12-26-19(34-29-12)17-28-20-16(21(33)31(17)11-15(23)24)27-22(35-20)30-9-5-8-14(30)18(32)25-10-13-6-3-2-4-7-13/h2-4,6-7,14-15H,5,8-11H2,1H3,(H,25,32)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273157
PNG
((R)-N-benzyl-1-(5-methyl-9-oxo-5,9-dihydroimidazo[...)
Show SMILES Cn1ccn2c1nc1sc(nc1c2=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H20N6O2S/c1-24-10-11-26-18(28)15-17(23-19(24)26)29-20(22-15)25-9-5-8-14(25)16(27)21-12-13-6-3-2-4-7-13/h2-4,6-7,10-11,14H,5,8-9,12H2,1H3,(H,21,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273093
PNG
((R)-N-[dideuterio(phenyl)methyl]-1-(6-methyl-7-oxo...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O2S/c1-28-20(17-11-6-3-7-12-17)27-22-19(23(28)31)26-24(32-22)29-14-8-13-18(29)21(30)25-15-16-9-4-2-5-10-16/h2-7,9-12,18H,8,13-15H2,1H3,(H,25,30)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273114
PNG
((R)-N-benzyl-1-[5-(N',N'-dimethylamino)-6-methyl-7...)
Show SMILES CN(C)c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H24N6O2S/c1-24(2)19-23-17-15(18(28)25(19)3)22-20(29-17)26-11-7-10-14(26)16(27)21-12-13-8-5-4-6-9-13/h4-6,8-9,14H,7,10-12H2,1-3H3,(H,21,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273096
PNG
((R)-N-benzyl-1-{5-[difluoro(pyridin-2-yl)methyl]-6...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)c1ccccn1
Show InChI InChI=1S/C24H22F2N6O2S/c1-31-21(34)18-20(30-22(31)24(25,26)17-11-5-6-12-27-17)35-23(29-18)32-13-7-10-16(32)19(33)28-14-15-8-3-2-4-9-15/h2-6,8-9,11-12,16H,7,10,13-14H2,1H3,(H,28,33)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273131
PNG
((R)-N-benzyl-1-[5-(2-fluorophenyl)-7-oxo-6,7-dihyd...)
Show SMILES Fc1ccccc1-c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273030
PNG
((R)-2-[5-(1-cyanocyclopropyl)-7-oxo-6,7-dihydro[1,...)
Show SMILES Cc1cccc(OC(=O)N2CCC[C@@H]2c2nc3c(nc([nH]c3=O)C3(CC3)C#N)s2)c1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273139
PNG
((R)-N-benzyl-1-(7-oxo-5-trifluoromethyl-6,7-dihydr...)
Show SMILES FC(F)(F)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273076
PNG
((R)-N-benzyl-1-[5-(2,6-difluorophenyl)-6-methyl-7-...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1c(F)cccc1F
Show InChI InChI=1S/C24H21F2N5O2S/c1-30-20(18-15(25)9-5-10-16(18)26)29-22-19(23(30)33)28-24(34-22)31-12-6-11-17(31)21(32)27-13-14-7-3-2-4-8-14/h2-5,7-10,17H,6,11-13H2,1H3,(H,27,32)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273132
PNG
((R)-1-[5-(2,4-difluorophenyl)-7-oxo-6,7-dihydro[1,...)
Show SMILES C[C@@H](NC(=O)[C@H]1CCCN1c1nc2c(nc([nH]c2=O)-c2ccc(F)cc2F)s1)c1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273077
PNG
((R)-N-benzyl-1-[6-methyl-5-(3-methyl-1,2,4-oxadiaz...)
Show SMILES Cc1noc(n1)-c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H21N7O3S/c1-12-23-18(31-26-12)16-25-19-15(20(30)27(16)2)24-21(32-19)28-10-6-9-14(28)17(29)22-11-13-7-4-3-5-8-13/h3-5,7-8,14H,6,9-11H2,1-2H3,(H,22,29)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273159
PNG
((R)-N-benzyl-1-[5-(2-hydroxypropan-2-yl)-7-oxo-6,7...)
Show SMILES CC(C)(O)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273116
PNG
((R)-N-benzyl-1-[6-methyl-5-(morpholin-4-yl)-7-oxo-...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)N1CCOCC1
Show InChI InChI=1S/C22H26N6O3S/c1-26-20(30)17-19(25-21(26)27-10-12-31-13-11-27)32-22(24-17)28-9-5-8-16(28)18(29)23-14-15-6-3-2-4-7-15/h2-4,6-7,16H,5,8-14H2,1H3,(H,23,29)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273123
PNG
((R)-N-benzyl-1-[6-{2-[N'-methyl-N'-(2,2,2-trifluor...)
Show SMILES CN(CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F)CC(F)(F)F
Show InChI InChI=1S/C23H24F6N6O2S/c1-33(13-22(24,25)26)10-11-35-19(37)16-18(32-20(35)23(27,28)29)38-21(31-16)34-9-5-8-15(34)17(36)30-12-14-6-3-2-4-7-14/h2-4,6-7,15H,5,8-13H2,1H3,(H,30,36)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273158
PNG
((R)-N-benzyl-1-(5,5-difluoro-10-oxo-5,7,8,10-tetra...)
Show SMILES FC1(F)CCCn2c1nc1sc(nc1c2=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H21F2N5O2S/c22-21(23)9-5-11-28-18(30)15-17(26-19(21)28)31-20(25-15)27-10-4-8-14(27)16(29)24-12-13-6-2-1-3-7-13/h1-3,6-7,14H,4-5,8-12H2,(H,24,29)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273028
PNG
((R)-2-{5-[1-(fluoromethyl)cyclopropyl]-7-oxo-6,7-d...)
Show SMILES FCC1(CC1)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273118
PNG
((R)-N-benzyl-1-[5-(2-fluorophenyl)-6-methyl-7-oxo-...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1F
Show InChI InChI=1S/C24H22FN5O2S/c1-29-20(16-10-5-6-11-17(16)25)28-22-19(23(29)32)27-24(33-22)30-13-7-12-18(30)21(31)26-14-15-8-3-2-4-9-15/h2-6,8-11,18H,7,12-14H2,1H3,(H,26,31)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273095
PNG
((R)-N-benzyl-1-[5-(1-fluorocyclopropyl)-6-methyl-7...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C1(F)CC1
Show InChI InChI=1S/C21H22FN5O2S/c1-26-18(29)15-17(25-19(26)21(22)9-10-21)30-20(24-15)27-11-5-8-14(27)16(28)23-12-13-6-3-2-4-7-13/h2-4,6-7,14H,5,8-12H2,1H3,(H,23,28)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273151
PNG
((R)-N-benzyl-1-[5-(2,6-difluorophenyl)-7-oxo-6,7-d...)
Show SMILES Fc1cccc(F)c1-c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273129
PNG
((R)-N-benzyl-1-[5-(2-fluoropropan-2-yl)-7-oxo-6,7-...)
Show SMILES CC(C)(F)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273145
PNG
((R)-N-benzyl-1-[5-methoxymethyl-7-oxo-6-(tetrahydr...)
Show SMILES COCc1nc2sc(nc2c(=O)n1C1CCOCC1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H29N5O4S/c1-32-15-19-26-22-20(23(31)29(19)17-9-12-33-13-10-17)27-24(34-22)28-11-5-8-18(28)21(30)25-14-16-6-3-2-4-7-16/h2-4,6-7,17-18H,5,8-15H2,1H3,(H,25,30)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273150
PNG
(5-ethyl-6-methyl-2-[(R)-2-(2-phenylaminoacetyl)pyr...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)CNc1ccccc1
Show InChI InChI=1S/C20H23N5O2S/c1-3-16-22-18-17(19(27)24(16)2)23-20(28-18)25-11-7-10-14(25)15(26)12-21-13-8-5-4-6-9-13/h4-6,8-9,14,21H,3,7,10-12H2,1-2H3/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273117
PNG
((R)-N-benzyl-1-{6-methyl-7-oxo-5-[(propan-2-yl)ami...)
Show SMILES CC(C)Nc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H26N6O2S/c1-13(2)23-20-25-18-16(19(29)26(20)3)24-21(30-18)27-11-7-10-15(27)17(28)22-12-14-8-5-4-6-9-14/h4-6,8-9,13,15H,7,10-12H2,1-3H3,(H,22,28)(H,23,25)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273144
PNG
(N-[dideuterio(phenyl)methyl]-1-[7-oxo-5-phenyl-6-(...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O2S/c1-28-20(17-11-6-3-7-12-17)27-22-19(23(28)31)26-24(32-22)29-14-8-13-18(29)21(30)25-15-16-9-4-2-5-10-16/h2-7,9-12,18H,8,13-15H2,1H3,(H,25,30)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273085
PNG
((R)-N-benzyl-1-[7-oxo-6-(tetrahydro-2H-pyran-4-yl)...)
Show SMILES FC(F)(F)c1nc2sc(nc2c(=O)n1C1CCOCC1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H24F3N5O3S/c24-23(25,26)21-29-19-17(20(33)31(21)15-8-11-34-12-9-15)28-22(35-19)30-10-4-7-16(30)18(32)27-13-14-5-2-1-3-6-14/h1-3,5-6,15-16H,4,7-13H2,(H,27,32)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273089
PNG
((R)-N-benzyl-1-{5-difluoromethyl-7-oxo-6-[(tetrahy...)
Show SMILES FC(F)c1nc2sc(nc2c(=O)n1CC1CCOCC1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H27F2N5O3S/c25-19(26)20-29-22-18(23(33)31(20)14-16-8-11-34-12-9-16)28-24(35-22)30-10-4-7-17(30)21(32)27-13-15-5-2-1-3-6-15/h1-3,5-6,16-17,19H,4,7-14H2,(H,27,32)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273070
PNG
((R)-N-benzyl-1-(6-methyl-7-oxo-5-phenyl-6,7-dihydr...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O2S/c1-28-20(17-11-6-3-7-12-17)27-22-19(23(28)31)26-24(32-22)29-14-8-13-18(29)21(30)25-15-16-9-4-2-5-10-16/h2-7,9-12,18H,8,13-15H2,1H3,(H,25,30)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273152
PNG
((R)-N-benzyl-1-[5-(3-methyl-[1,2,4]oxadiazol-5-yl)...)
Show SMILES Cc1noc(n1)-c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273032
PNG
(2-[(R)-1-(phenylacetyl)pyrrolidin-2-yl]-5-[1-(trif...)
Show SMILES FC(F)(F)C1(CC1)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Cc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273075
PNG
((R)-N-benzyl-1-[6-methyl-7-oxo-5-(2,4,6-trifluorop...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1c(F)cc(F)cc1F
Show InChI InChI=1S/C24H20F3N5O2S/c1-31-20(18-15(26)10-14(25)11-16(18)27)30-22-19(23(31)34)29-24(35-22)32-9-5-8-17(32)21(33)28-12-13-6-3-2-4-7-13/h2-4,6-7,10-11,17H,5,8-9,12H2,1H3,(H,28,33)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273124
PNG
((R)-N-benzyl-1-{5-[(R)-1-(N',N'-dimethylamino)ethy...)
Show SMILES C[C@@H](N(C)C)c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H28N6O2S/c1-14(26(2)3)18-25-20-17(21(30)27(18)4)24-22(31-20)28-12-8-11-16(28)19(29)23-13-15-9-6-5-7-10-15/h5-7,9-10,14,16H,8,11-13H2,1-4H3,(H,23,29)/t14-,16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273025
PNG
((R)-2-[5-(2,4-difluorophenyl)-7-oxo-6,7-dihydro[1,...)
Show SMILES Fc1ccc(c(F)c1)-c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
PDB
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273040
PNG
((R)-2-[5-(3-methyloxetan-3-yl)-7-oxo-6,7-dihydro[1...)
Show SMILES CC1(COC1)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273130
PNG
((R)-N-benzyl-2-{N'-[5-(propan-2-yl)-7-oxo-6,7-dihy...)
Show SMILES CC(C)c1nc2sc(nc2c(=O)[nH]1)N(C)[C@H](C)C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273023
PNG
((R)-2-[7-oxo-5-(propan-2-yl)-6,7-dihydro[1,3]thiaz...)
Show SMILES CC(C)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273168
PNG
((R)-N-benzyl-1-[7-chloro-6-(2-fluoropropan-2-yl)-4...)
Show SMILES CC(C)(F)c1[nH]c(=O)c2nc(sc2c1Cl)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273167
PNG
((R)-N-benzyl-1-[7-chloro-6-(2-fluorophenyl)-4-oxo-...)
Show SMILES Fc1ccccc1-c1[nH]c(=O)c2nc(sc2c1Cl)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273127
PNG
((R)-1-(5-acetyl-6-methyl-7-oxo-6,7-dihydro[1,3]thi...)
Show SMILES CC(=O)c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H21N5O3S/c1-12(26)16-23-18-15(19(28)24(16)2)22-20(29-18)25-10-6-9-14(25)17(27)21-11-13-7-4-3-5-8-13/h3-5,7-8,14H,6,9-11H2,1-2H3,(H,21,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273078
PNG
((R)-N-(4-fluorobenzyl)-1-[6-methyl-5-(3-methyl-[1,...)
Show SMILES Cc1noc(n1)-c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C21H20FN7O3S/c1-11-24-18(32-27-11)16-26-19-15(20(31)28(16)2)25-21(33-19)29-9-3-4-14(29)17(30)23-10-12-5-7-13(22)8-6-12/h5-8,14H,3-4,9-10H2,1-2H3,(H,23,30)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273119
PNG
((R)-N-benzyl-1-[6-methyl-7-oxo-5-(2,3,4,5,6-pentad...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O2S/c1-28-20(17-11-6-3-7-12-17)27-22-19(23(28)31)26-24(32-22)29-14-8-13-18(29)21(30)25-15-16-9-4-2-5-10-16/h2-7,9-12,18H,8,13-15H2,1H3,(H,25,30)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273143
PNG
((R)-N-benzyl-1-[7-oxo-5-phenyl-6-(trideuteriomethy...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O2S/c1-28-20(17-11-6-3-7-12-17)27-22-19(23(28)31)26-24(32-22)29-14-8-13-18(29)21(30)25-15-16-9-4-2-5-10-16/h2-7,9-12,18H,8,13-15H2,1H3,(H,25,30)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273084
PNG
((R)-N-benzyl-1-(6-cyclopentyl-7-oxo-6,7-dihydro-[1...)
Show SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1nc2c(ncn(C3CCCC3)c2=O)s1
Show InChI InChI=1S/C22H25N5O2S/c28-19(23-13-15-7-2-1-3-8-15)17-11-6-12-26(17)22-25-18-20(30-22)24-14-27(21(18)29)16-9-4-5-10-16/h1-3,7-8,14,16-17H,4-6,9-13H2,(H,23,28)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273163
PNG
((R)-N-benzyl-1-(7-cyclopropyl-5-ethyl-4-oxo-4,5-di...)
Show SMILES CCn1nc(C2CC2)c2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H25N5O2S/c1-2-27-21(29)18-19(17(25-27)15-10-11-15)30-22(24-18)26-12-6-9-16(26)20(28)23-13-14-7-4-3-5-8-14/h3-5,7-8,15-16H,2,6,9-13H2,1H3,(H,23,28)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273112
PNG
((R)-N-benzyl-1-{5-[(1,3-dihydro-2H-isoindol-2-yl)m...)
Show SMILES Cn1c(CN2Cc3ccccc3C2)nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C27H28N6O2S/c1-31-22(17-32-15-19-10-5-6-11-20(19)16-32)29-25-23(26(31)35)30-27(36-25)33-13-7-12-21(33)24(34)28-14-18-8-3-2-4-9-18/h2-6,8-11,21H,7,12-17H2,1H3,(H,28,34)/t21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273134
PNG
((R)-N-benzyl-1-[5-(3-fluoro-5-methylthiophen-2-yl)...)
Show SMILES Cc1cc(F)c(s1)-c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273138
PNG
((R)-N-benzyl-2-{N'-[5-(2-fluorophenyl)-7-oxo-6,7-d...)
Show SMILES C[C@@H](N(C)c1nc2c(nc([nH]c2=O)-c2ccccc2F)s1)C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273022
PNG
((R)-2-[6-methyl-7-oxo-5-(tetrahydro-2H-pyran-4-yl)...)
Show SMILES Cc1cccc(OC(=O)N2CCC[C@@H]2c2nc3c(nc(C4CCOCC4)n(C)c3=O)s2)c1
Show InChI InChI=1S/C23H26N4O4S/c1-14-5-3-6-16(13-14)31-23(29)27-10-4-7-17(27)20-24-18-21(32-20)25-19(26(2)22(18)28)15-8-11-30-12-9-15/h3,5-6,13,15,17H,4,7-12H2,1-2H3/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273186
PNG
((R)-N-(2-chlorobenzyl)-1-(7-ethyl-6-fluoro-5-oxo-5...)
Show SMILES CCc1nc2sc(nn2c(=O)c1F)N1CCC[C@@H]1C(=O)NCc1ccccc1Cl
Show InChI InChI=1S/C19H19ClFN5O2S/c1-2-13-15(21)17(28)26-18(23-13)29-19(24-26)25-9-5-8-14(25)16(27)22-10-11-6-3-4-7-12(11)20/h3-4,6-7,14H,2,5,8-10H2,1H3,(H,22,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273031
PNG
((R)-2-{5-[1-(methoxymethyl)cyclopropyl]-7-oxo-6,7-...)
Show SMILES COCC1(CC1)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273148
PNG
(5-ethyl-6-methyl-2-[(R)-2-(2-phenoxyacetyl)pyrroli...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)COc1ccccc1
Show InChI InChI=1S/C20H22N4O3S/c1-3-16-21-18-17(19(26)23(16)2)22-20(28-18)24-11-7-10-14(24)15(25)12-27-13-8-5-4-6-9-13/h4-6,8-9,14H,3,7,10-12H2,1-2H3/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273136
PNG
((R)-N-benzyl-1-[5-(3-benzenesulfonyl-1,1-difluorop...)
Show SMILES FC(F)(CCS(=O)(=O)c1ccccc1)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273087
PNG
((R)-N-benzyl-1-[7-oxo-6-(pyrrolidin-1-yl)-5-triflu...)
Show SMILES FC(F)(F)c1nc2sc(nc2c(=O)n1N1CCCC1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H23F3N6O2S/c23-22(24,25)20-28-18-16(19(33)31(20)29-10-4-5-11-29)27-21(34-18)30-12-6-9-15(30)17(32)26-13-14-7-2-1-3-8-14/h1-3,7-8,15H,4-6,9-13H2,(H,26,32)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273110
PNG
((R)-N-benzyl-1-{6-methyl-5-[(morpholin-4-yl)methyl...)
Show SMILES Cn1c(CN2CCOCC2)nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C23H28N6O3S/c1-27-18(15-28-10-12-32-13-11-28)25-21-19(22(27)31)26-23(33-21)29-9-5-8-17(29)20(30)24-14-16-6-3-2-4-7-16/h2-4,6-7,17H,5,8-15H2,1H3,(H,24,30)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273103
PNG
((R)-N-[(benzo[1,3]dioxo-5-yl)methyl]-1-(5-difluoro...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccc2OCOc2c1)C(F)F
Show InChI InChI=1S/C21H21F2N5O4S/c1-2-27-17(16(22)23)26-19-15(20(27)30)25-21(33-19)28-7-3-4-12(28)18(29)24-9-11-5-6-13-14(8-11)32-10-31-13/h5-6,8,12,16H,2-4,7,9-10H2,1H3,(H,24,29)/t12-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273081
PNG
((R)-1-(5,6-dimethyl-7-oxo-6,7-dihydro-[1,3]thiazol...)
Show SMILES Cc1ccccc1CNC(=O)[C@H]1CCCN1c1nc2c(nc(C)n(C)c2=O)s1
Show InChI InChI=1S/C20H23N5O2S/c1-12-7-4-5-8-14(12)11-21-17(26)15-9-6-10-25(15)20-23-16-18(28-20)22-13(2)24(3)19(16)27/h4-5,7-8,15H,6,9-11H2,1-3H3,(H,21,26)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273162
PNG
((R)-N-benzyl-1-[7-ethyl-4-oxo-5-(tetrahydro-2H-pyr...)
Show SMILES CCc1nn(C2CCOCC2)c(=O)c2nc(sc12)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H29N5O3S/c1-2-18-21-20(23(31)29(27-18)17-10-13-32-14-11-17)26-24(33-21)28-12-6-9-19(28)22(30)25-15-16-7-4-3-5-8-16/h3-5,7-8,17,19H,2,6,9-15H2,1H3,(H,25,30)/t19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273140
PNG
((R)-N-benzyl-1-(5-difluoromethyl-7-oxo-6,7-dihydro...)
Show SMILES FC(F)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273094
PNG
((R)-1-[5-(1,1-difluoroethyl)-6-methyl-7-oxo-6,7-di...)
Show SMILES C[C@@H](NC(=O)[C@H]1CCCN1c1nc2c(nc(n(C)c2=O)C(C)(F)F)s1)c1ccccc1
Show InChI InChI=1S/C21H23F2N5O2S/c1-12(13-8-5-4-6-9-13)24-16(29)14-10-7-11-28(14)20-25-15-17(31-20)26-19(21(2,22)23)27(3)18(15)30/h4-6,8-9,12,14H,7,10-11H2,1-3H3,(H,24,29)/t12-,14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273166
PNG
((R)-N-benzyl-1-(7-chloro-6-cyclopropyl-4-oxo-4,5-d...)
Show SMILES Clc1c([nH]c(=O)c2nc(sc12)N1CCC[C@@H]1C(=O)NCc1ccccc1)C1CC1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273046
PNG
((R)-2-[6-methyl-7-oxo-5-(propan-2-yl)-6,7-dihydro[...)
Show SMILES CC(C)c1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C20H22N4O3S/c1-12(2)16-22-18-15(19(25)23(16)3)21-17(28-18)14-10-7-11-24(14)20(26)27-13-8-5-4-6-9-13/h4-6,8-9,12,14H,7,10-11H2,1-3H3/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM274960
PNG
((R)-N-benzyl-1-[7-oxo-5-(piperidin-1-yl)-6,7-dihyd...)
Show SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1nc2c(nc([nH]c2=O)N2CCCCC2)s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273024
PNG
((R)-2-(7-oxo-5-phenyl-6,7-dihydro[1,3]thiazolo[5,4...)
Show SMILES O=C(Oc1ccccc1)N1CCC[C@@H]1c1nc2c(nc([nH]c2=O)-c2ccccc2)s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273020
PNG
((R)-2-(5-ethyl-6-methyl-7-oxo-6,7-dihydro[1,3]thia...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C19H20N4O3S/c1-3-14-20-17-15(18(24)22(14)2)21-16(27-17)13-10-7-11-23(13)19(25)26-12-8-5-4-6-9-12/h4-6,8-9,13H,3,7,10-11H2,1-2H3/t13-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273072
PNG
((R)-N-benzyl-1-(6-methyl-7-oxo-5-trifluoromethyl-6...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N5O2S/c1-26-16(29)13-15(25-17(26)19(20,21)22)30-18(24-13)27-9-5-8-12(27)14(28)23-10-11-6-3-2-4-7-11/h2-4,6-7,12H,5,8-10H2,1H3,(H,23,28)/t12-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273099
PNG
((R)-N-benzyl-1-[5-(3-fluoropyridin-2-yl)-6-methyl-...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ncccc1F
Show InChI InChI=1S/C23H21FN6O2S/c1-29-19(17-15(24)9-5-11-25-17)28-21-18(22(29)32)27-23(33-21)30-12-6-10-16(30)20(31)26-13-14-7-3-2-4-8-14/h2-5,7-9,11,16H,6,10,12-13H2,1H3,(H,26,31)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273097
PNG
((R)-N-benzyl-1-(5-difluoromethyl-6-methyl-7-oxo-6,...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)F
Show InChI InChI=1S/C19H19F2N5O2S/c1-25-15(14(20)21)24-17-13(18(25)28)23-19(29-17)26-9-5-8-12(26)16(27)22-10-11-6-3-2-4-7-11/h2-4,6-7,12,14H,5,8-10H2,1H3,(H,22,27)/t12-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273149
PNG
(5-(3-methoxyazetidin-1-yl)-6-methyl-2-[(R)-2-(2-ph...)
Show SMILES COC1CN(C1)c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)COc1ccccc1
Show InChI InChI=1S/C22H25N5O4S/c1-25-20(29)18-19(24-21(25)26-11-15(12-26)30-2)32-22(23-18)27-10-6-9-16(27)17(28)13-31-14-7-4-3-5-8-14/h3-5,7-8,15-16H,6,9-13H2,1-2H3/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273181
PNG
((R)-1-(5-oxo-5H-[1,3,4]thiadiazolo[2,3-b]quinazoli...)
Show SMILES O=C(NC1(CC1)c1ccccc1)[C@H]1CCCN1c1nn2c(nc3ccccc3c2=O)s1
Show InChI InChI=1S/C23H21N5O2S/c29-19(25-23(12-13-23)15-7-2-1-3-8-15)18-11-6-14-27(18)22-26-28-20(30)16-9-4-5-10-17(16)24-21(28)31-22/h1-5,7-10,18H,6,11-14H2,(H,25,29)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273173
PNG
((R)-N-benzyl-1-(5-oxo-7-phenyl-5H-[1,3,4]thiadiazo...)
Show SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1nn2c(nc(cc2=O)-c2ccccc2)s1
Show InChI InChI=1S/C23H21N5O2S/c29-20-14-18(17-10-5-2-6-11-17)25-22-28(20)26-23(31-22)27-13-7-12-19(27)21(30)24-15-16-8-3-1-4-9-16/h1-6,8-11,14,19H,7,12-13,15H2,(H,24,30)/t19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273039
PNG
((R)-2-(5-ethyl-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-...)
Show SMILES CCc1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273190
PNG
((R)-N-(2,4-dichlorobenzyl)-1-(7-ethyl-6-fluoro-5-o...)
Show SMILES CCc1nc2sc(nn2c(=O)c1F)N1CCC[C@@H]1C(=O)NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H18Cl2FN5O2S/c1-2-13-15(22)17(29)27-18(24-13)30-19(25-27)26-7-3-4-14(26)16(28)23-9-10-5-6-11(20)8-12(10)21/h5-6,8,14H,2-4,7,9H2,1H3,(H,23,28)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273073
PNG
((R)-N-benzyl-1-[5-difluoromethyl-6-(2-methoxy-ethy...)
Show SMILES COCCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)F
Show InChI InChI=1S/C21H23F2N5O3S/c1-31-11-10-28-17(16(22)23)26-19-15(20(28)30)25-21(32-19)27-9-5-8-14(27)18(29)24-12-13-6-3-2-4-7-13/h2-4,6-7,14,16H,5,8-12H2,1H3,(H,24,29)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273156
PNG
((R)-N-benzyl-1-(5-methyl-9-oxo-5,6,7,9-tetrahydroi...)
Show SMILES CN1CCn2c1nc1sc(nc1c2=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H22N6O2S/c1-24-10-11-26-18(28)15-17(23-19(24)26)29-20(22-15)25-9-5-8-14(25)16(27)21-12-13-6-3-2-4-7-13/h2-4,6-7,14H,5,8-12H2,1H3,(H,21,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273071
PNG
((R)-1-(5-ethyl-6-methyl-7-oxo-6,7-dihydro-[1,3]thi...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1cccc(F)c1
Show InChI InChI=1S/C20H22FN5O2S/c1-3-15-23-18-16(19(28)25(15)2)24-20(29-18)26-9-5-8-14(26)17(27)22-11-12-6-4-7-13(21)10-12/h4,6-7,10,14H,3,5,8-9,11H2,1-2H3,(H,22,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273147
PNG
((R)-N-benzyl-1-[5-(1-cyanocyclopropyl)-6-methyl-7-...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C1(CC1)C#N
Show InChI InChI=1S/C22H22N6O2S/c1-27-19(30)16-18(26-20(27)22(13-23)9-10-22)31-21(25-16)28-11-5-8-15(28)17(29)24-12-14-6-3-2-4-7-14/h2-4,6-7,15H,5,8-12H2,1H3,(H,24,29)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273033
PNG
(2-{(R)-1-[2-(3-methylphenyl)acetyl]pyrrolidin-2-yl...)
Show SMILES Cc1cccc(CC(=O)N2CCC[C@@H]2c2nc3c(nc([nH]c3=O)C3(CC3)C(F)(F)F)s2)c1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273122
PNG
((R)-N-benzyl-1-{6-[2-(N',N'-dimethylamino)ethyl]-7...)
Show SMILES CN(C)CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N6O2S/c1-29(2)11-12-31-19(33)16-18(28-20(31)22(23,24)25)34-21(27-16)30-10-6-9-15(30)17(32)26-13-14-7-4-3-5-8-14/h3-5,7-8,15H,6,9-13H2,1-2H3,(H,26,32)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273086
PNG
((R)-N-benzyl-1-[6-(oxetan-3-yl)-7-oxo-5-trifluorom...)
Show SMILES FC(F)(F)c1nc2sc(nc2c(=O)n1C1COC1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H20F3N5O3S/c22-21(23,24)19-27-17-15(18(31)29(19)13-10-32-11-13)26-20(33-17)28-8-4-7-14(28)16(30)25-9-12-5-2-1-3-6-12/h1-3,5-6,13-14H,4,7-11H2,(H,25,30)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273026
PNG
((R)-2-[5-(2-methylphenyl)-7-oxo-6,7-dihydro[1,3]th...)
Show SMILES Cc1ccccc1-c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273133
PNG
((R)-N-benzyl-1-[5-(5-methylthiophen-2-yl)-7-oxo-6,...)
Show SMILES Cc1ccc(s1)-c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273128
PNG
((R)-N-benzyl-1-[6-(2,4-dimethoxybenzyl)-5-(2-fluor...)
Show SMILES COc1ccc(Cn2c(nc3sc(nc3c2=O)N2CCC[C@@H]2C(=O)NCc2ccccc2)C(C)(C)F)c(OC)c1
Show InChI InChI=1S/C29H32FN5O4S/c1-29(2,30)27-33-25-23(26(37)35(27)17-19-12-13-20(38-3)15-22(19)39-4)32-28(40-25)34-14-8-11-21(34)24(36)31-16-18-9-6-5-7-10-18/h5-7,9-10,12-13,15,21H,8,11,14,16-17H2,1-4H3,(H,31,36)/t21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273141
PNG
((R)-N-benzyl-1-{7-oxo-5-[(S)-2-(trifluoromethyl)py...)
Show SMILES FC(F)(F)[C@@H]1CCCN1c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273019
PNG
((R)-2-[6-methyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)...)
Show SMILES Cc1noc(n1)-c1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C20H18N6O4S/c1-11-21-16(30-24-11)15-23-18-14(19(27)25(15)2)22-17(31-18)13-9-6-10-26(13)20(28)29-12-7-4-3-5-8-12/h3-5,7-8,13H,6,9-10H2,1-2H3/t13-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273182
PNG
((R)-N-benzyl-1-(6-methyl-8-oxo-8H-[1,3,4]thiadiazo...)
Show SMILES Cc1cc2c(nc3sc(nn3c2=O)N2CCC[C@@H]2C(=O)NCc2ccccc2)s1
Show InChI InChI=1S/C20H19N5O2S2/c1-12-10-14-17(28-12)22-19-25(18(14)27)23-20(29-19)24-9-5-8-15(24)16(26)21-11-13-6-3-2-4-7-13/h2-4,6-7,10,15H,5,8-9,11H2,1H3,(H,21,26)/t15-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273178
PNG
((R)-N-benzyl-1-(7-methyl-5-oxo-6-phenyl-5H-[1,3,4]...)
Show SMILES Cc1nc2sc(nn2c(=O)c1-c1ccccc1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H23N5O2S/c1-16-20(18-11-6-3-7-12-18)22(31)29-23(26-16)32-24(27-29)28-14-8-13-19(28)21(30)25-15-17-9-4-2-5-10-17/h2-7,9-12,19H,8,13-15H2,1H3,(H,25,30)/t19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273037
PNG
((R)-2-[7-oxo-5-(piperidin-1-yl)-6,7-dihydro[1,3]th...)
Show SMILES O=C(Oc1ccccc1)N1CCC[C@@H]1c1nc2c(nc([nH]c2=O)N2CCCCC2)s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273169
PNG
((R)-N-benzyl-1-[6-(1-ethoxycyclopropyl)-4-oxo-4,5-...)
Show SMILES CCOC1(CC1)c1cc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273057
PNG
((R)-2-[6-chloro-5-oxo-7-(propan-2-yl)-5H-[1,3,4]th...)
Show SMILES CC(C)c1nc2sc(nn2c(=O)c1Cl)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C19H19ClN4O3S/c1-11(2)15-14(20)17(25)24-18(21-15)28-16(22-24)13-9-6-10-23(13)19(26)27-12-7-4-3-5-8-12/h3-5,7-8,11,13H,6,9-10H2,1-2H3/t13-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273113
PNG
((R)-N-benzyl-1-[6-methyl-5-{[N'-methyl-N'-(2,2,2-t...)
Show SMILES CN(Cc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1)CC(F)(F)F
Show InChI InChI=1S/C22H25F3N6O2S/c1-29(13-22(23,24)25)12-16-27-19-17(20(33)30(16)2)28-21(34-19)31-10-6-9-15(31)18(32)26-11-14-7-4-3-5-8-14/h3-5,7-8,15H,6,9-13H2,1-2H3,(H,26,32)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273174
PNG
((R)-N-benzyl-1-(5-oxo-6,7,8,9-tetrahydro-5H-[1,3,4...)
Show SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1nn2c(nc3CCCCc3c2=O)s1
Show InChI InChI=1S/C21H23N5O2S/c27-18(22-13-14-7-2-1-3-8-14)17-11-6-12-25(17)21-24-26-19(28)15-9-4-5-10-16(15)23-20(26)29-21/h1-3,7-8,17H,4-6,9-13H2,(H,22,27)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273193
PNG
((R)-N-benzyl-1-(6,8-dichloro-7-ethyl-5-oxo-5H-[1,3...)
Show SMILES CCc1c(Cl)c2sc(nn2c(=O)c1Cl)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H20Cl2N4O2S/c1-2-13-15(21)18(28)26-19(16(13)22)29-20(24-26)25-10-6-9-14(25)17(27)23-11-12-7-4-3-5-8-12/h3-5,7-8,14H,2,6,9-11H2,1H3,(H,23,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273154
PNG
((R)-N-benzyl-1-[6-(2,2-difluoroethyl)-10-oxo-5,7,8...)
Show SMILES FC(F)CN1CCn2c(C1)nc1sc(nc1c2=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H24F2N6O2S/c23-16(24)12-28-9-10-30-17(13-28)26-20-18(21(30)32)27-22(33-20)29-8-4-7-15(29)19(31)25-11-14-5-2-1-3-6-14/h1-3,5-6,15-16H,4,7-13H2,(H,25,31)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273043
PNG
(2-[5-(2-fluoropropan-2-yl)-7-oxo-6,7-dihydro[1,3]t...)
Show SMILES Cc1cccc(OC(=O)N2CCCN2c2nc3c(nc([nH]c3=O)C(C)(C)F)s2)c1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273161
PNG
((R)-N-benzyl-1-(5,7-diethyl-4-oxo-4,5-dihydro[1,3]...)
Show SMILES CCc1nn(CC)c(=O)c2nc(sc12)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H25N5O2S/c1-3-15-18-17(20(28)26(4-2)24-15)23-21(29-18)25-12-8-11-16(25)19(27)22-13-14-9-6-5-7-10-14/h5-7,9-10,16H,3-4,8,11-13H2,1-2H3,(H,22,27)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273170
PNG
((R)-N-benzyl-1-(5-methyl-4-oxo-6-trifluoromethyl-4...)
Show SMILES Cn1c(cc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O2S/c1-26-15(20(21,22)23)10-14-16(18(26)29)25-19(30-14)27-9-5-8-13(27)17(28)24-11-12-6-3-2-4-7-12/h2-4,6-7,10,13H,5,8-9,11H2,1H3,(H,24,28)/t13-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273016
PNG
((R)-2-{1-[2-(3,4-dihydro-2H-quinolin-1-yl)acetyl]p...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)CN1CCCc2ccccc12
Show InChI InChI=1S/C23H27N5O2S/c1-3-18-24-22-20(23(30)26(18)2)25-21(31-22)17-11-7-13-28(17)19(29)14-27-12-6-9-15-8-4-5-10-16(15)27/h4-5,8,10,17H,3,6-7,9,11-14H2,1-2H3/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273177
PNG
((R)-N-benzyl-1-[7-methyl-5-oxo-6-(propan-2-yl)-5H-...)
Show SMILES CC(C)c1c(C)nc2sc(nn2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H25N5O2S/c1-13(2)17-14(3)23-20-26(19(17)28)24-21(29-20)25-11-7-10-16(25)18(27)22-12-15-8-5-4-6-9-15/h4-6,8-9,13,16H,7,10-12H2,1-3H3,(H,22,27)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273105
PNG
((R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1cccs1)C(F)F
Show InChI InChI=1S/C18H19F2N5O2S2/c1-2-24-14(13(19)20)23-16-12(17(24)27)22-18(29-16)25-7-3-6-11(25)15(26)21-9-10-5-4-8-28-10/h4-5,8,11,13H,2-3,6-7,9H2,1H3,(H,21,26)/t11-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273198
PNG
((R)-N-benzyl-1-[4-oxo-2-(propan-2-yl)-3,4-dihydrop...)
Show SMILES CC(C)c1nc2ccc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273035
PNG
((R)-2-[7-oxo-5-(2,2,2-trifluoroethoxy)-6,7-dihydro...)
Show SMILES FC(F)(F)COc1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273191
PNG
((R)-N-benzyl-1-[6-(3,6-dihydro-2H-pyran-4-yl)-7-me...)
Show SMILES CC1=C(C(=O)C2N=C(SC2=N1)N1CCC[C@@H]1C(=O)NCc1ccccc1)C1=CCOCC1
Show InChI InChI=1S/C24H26N4O3S/c1-15-19(17-9-12-31-13-10-17)21(29)20-23(26-15)32-24(27-20)28-11-5-8-18(28)22(30)25-14-16-6-3-2-4-7-16/h2-4,6-7,9,18,20H,5,8,10-14H2,1H3,(H,25,30)/t18-,20?/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273047
PNG
((R)-2-[6-(2-fluorophenyl)-4-oxo-4,5-dihydro[1,3]th...)
Show SMILES Fc1ccccc1-c1cc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273036
PNG
((R)-2-[5-(N,N-dimethylamino)-7-oxo-6,7-dihydro[1,3...)
Show SMILES CN(C)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273109
PNG
((R)-N-benzyl-1-{5-[(3-methoxyazetidin-1-yl)methyl]...)
Show SMILES COC1CN(Cc2nc3sc(nc3c(=O)n2C)N2CCC[C@@H]2C(=O)NCc2ccccc2)C1
Show InChI InChI=1S/C23H28N6O3S/c1-27-18(14-28-12-16(13-28)32-2)25-21-19(22(27)31)26-23(33-21)29-10-6-9-17(29)20(30)24-11-15-7-4-3-5-8-15/h3-5,7-8,16-17H,6,9-14H2,1-2H3,(H,24,30)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273080
PNG
((R)-N-benzyl-1-{6-[(3-methyloxetan-3-yl)methyl]-7-...)
Show SMILES CC1(Cn2c(nc3sc(nc3c2=O)N2CCC[C@@H]2C(=O)NCc2ccccc2)C(F)(F)F)COC1
Show InChI InChI=1S/C23H24F3N5O3S/c1-22(12-34-13-22)11-31-19(33)16-18(29-20(31)23(24,25)26)35-21(28-16)30-9-5-8-15(30)17(32)27-10-14-6-3-2-4-7-14/h2-4,6-7,15H,5,8-13H2,1H3,(H,27,32)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273034
PNG
((R)-2-[5-(1-methylcyclopropoxy)-7-oxo-6,7-dihydro[...)
Show SMILES CC1(CC1)Oc1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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n/an/a 73n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273164
PNG
((R)-N-benzyl-1-(5-cyclohexyl-7-methyl-4-oxo-4,5-di...)
Show SMILES Cc1nn(C2CCCCC2)c(=O)c2nc(sc12)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C24H29N5O2S/c1-16-21-20(23(31)29(27-16)18-11-6-3-7-12-18)26-24(32-21)28-14-8-13-19(28)22(30)25-15-17-9-4-2-5-10-17/h2,4-5,9-10,18-19H,3,6-8,11-15H2,1H3,(H,25,30)/t19-/m1/s1
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n/an/a 73n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273125
PNG
((R)-N-benzyl-1-[6-(2-hydroxyethyl)-7-oxo-5-trifluo...)
Show SMILES OCCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N5O3S/c21-20(22,23)18-26-16-14(17(31)28(18)9-10-29)25-19(32-16)27-8-4-7-13(27)15(30)24-11-12-5-2-1-3-6-12/h1-3,5-6,13,29H,4,7-11H2,(H,24,30)/t13-/m1/s1
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n/an/a 76n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273074
PNG
((R)-N-benzyl-1-[6-methyl-7-oxo-5-(pyridin-2-yl)-6,...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccn1
Show InChI InChI=1S/C23H22N6O2S/c1-28-19(16-10-5-6-12-24-16)27-21-18(22(28)31)26-23(32-21)29-13-7-11-17(29)20(30)25-14-15-8-3-2-4-9-15/h2-6,8-10,12,17H,7,11,13-14H2,1H3,(H,25,30)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273049
PNG
((R)-2-[5-oxo-7-(propan-2-yl)-5H-[1,3,4]thiadiazolo...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)Oc1ccc(F)cc1
Show InChI InChI=1S/C19H19FN4O3S/c1-11(2)14-10-16(25)24-18(21-14)28-17(22-24)15-4-3-9-23(15)19(26)27-13-7-5-12(20)6-8-13/h5-8,10-11,15H,3-4,9H2,1-2H3/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273111
PNG
((R)-N-benzyl-1-{5-[(N',N'-dimethylamino)methyl]-6-...)
Show SMILES CN(C)Cc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H26N6O2S/c1-25(2)13-16-23-19-17(20(29)26(16)3)24-21(30-19)27-11-7-10-15(27)18(28)22-12-14-8-5-4-6-9-14/h4-6,8-9,15H,7,10-13H2,1-3H3,(H,22,28)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273175
PNG
((R)-N-benzyl-1-(5-oxo-7-trifluoromethyl-5H-[1,3,4]...)
Show SMILES FC(F)(F)c1cc(=O)n2nc(sc2n1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C18H16F3N5O2S/c19-18(20,21)13-9-14(27)26-16(23-13)29-17(24-26)25-8-4-7-12(25)15(28)22-10-11-5-2-1-3-6-11/h1-3,5-6,9,12H,4,7-8,10H2,(H,22,28)/t12-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273027
PNG
((R)-2-[5-(4,4-difluorocyclohexyl)-7-oxo-6,7-dihydr...)
Show SMILES FC1(F)CCC(CC1)c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273146
PNG
((R)-N-benzyl-1-(5-cyclopropyl-6-methyl-7-oxo-6,7-d...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CC(F)(F)C[C@@H]1C(=O)NCc1ccccc1)C1CC1
Show InChI InChI=1S/C21H21F2N5O2S/c1-27-16(13-7-8-13)26-18-15(19(27)30)25-20(31-18)28-11-21(22,23)9-14(28)17(29)24-10-12-5-3-2-4-6-12/h2-6,13-14H,7-11H2,1H3,(H,24,29)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273199
PNG
((R)-N-benzyl-1-[2-(2-fluorophenyl)-4-oxo-3,4-dihyd...)
Show SMILES Fc1ccccc1-c1nc2ccc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273088
PNG
((R)-N-benzyl-1-[6-(morpholin-4-yl)-7-oxo-5-trifluo...)
Show SMILES FC(F)(F)c1nc2sc(nc2c(=O)n1N1CCOCC1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H23F3N6O3S/c23-22(24,25)20-28-18-16(19(33)31(20)29-9-11-34-12-10-29)27-21(35-18)30-8-4-7-15(30)17(32)26-13-14-5-2-1-3-6-14/h1-3,5-6,15H,4,7-13H2,(H,26,32)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273203
PNG
((R)-N-benzyl-1-[3-fluoro-4-oxo-2-(propan-2-yl)-4H-...)
Show SMILES CC(C)c1nc2ccc(nn2c(=O)c1F)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H24FN5O2/c1-14(2)20-19(23)22(30)28-17(25-20)10-11-18(26-28)27-12-6-9-16(27)21(29)24-13-15-7-4-3-5-8-15/h3-5,7-8,10-11,14,16H,6,9,12-13H2,1-2H3,(H,24,29)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273063
PNG
((R)-N-(1-phenylcyclopropyl)-2-[5-oxo-7-(propan-2-y...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)NC1(CC1)c1ccccc1
Show InChI InChI=1S/C22H25N5O2S/c1-14(2)16-13-18(28)27-21(23-16)30-19(25-27)17-9-6-12-26(17)20(29)24-22(10-11-22)15-7-4-3-5-8-15/h3-5,7-8,13-14,17H,6,9-12H2,1-2H3,(H,24,29)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273194
PNG
((R)-N-benzyl-1-(2-ethyl-3-methyl-4-oxo-3,4-dihydro...)
Show SMILES CCc1nc2ccc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H25N5O2/c1-3-18-24-16-11-12-19(25-20(16)22(29)26(18)2)27-13-7-10-17(27)21(28)23-14-15-8-5-4-6-9-15/h4-6,8-9,11-12,17H,3,7,10,13-14H2,1-2H3,(H,23,28)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273042
PNG
(2-[5-(2-fluoropropan-2-yl)-7-oxo-6,7-dihydro[1,3]t...)
Show SMILES CC(C)(F)c1nc2sc(nc2c(=O)[nH]1)N1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273082
PNG
((R)-N-benzyl-1-(5-ethyl-6-methyl-7-oxo-6,7-dihydro...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)N1CC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H21N5O2S/c1-3-14-21-17-15(18(26)23(14)2)22-19(27-17)24-10-9-13(24)16(25)20-11-12-7-5-4-6-8-12/h4-8,13H,3,9-11H2,1-2H3,(H,20,25)/t13-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273104
PNG
((R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccco1)C(F)F
Show InChI InChI=1S/C18H19F2N5O3S/c1-2-24-14(13(19)20)23-16-12(17(24)27)22-18(29-16)25-7-3-6-11(25)15(26)21-9-10-5-4-8-28-10/h4-5,8,11,13H,2-3,6-7,9H2,1H3,(H,21,26)/t11-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273120
PNG
((R)-N-benzyl-1-[6-(2-methylaminoethyl)-7-oxo-5-tri...)
Show SMILES CNCCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N6O2S/c1-25-9-11-30-18(32)15-17(28-19(30)21(22,23)24)33-20(27-15)29-10-5-8-14(29)16(31)26-12-13-6-3-2-4-7-13/h2-4,6-7,14,25H,5,8-12H2,1H3,(H,26,31)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273014
PNG
((R)-2-(5-ethyl-6-methyl-7-oxo-6,7-dihydro[1,3]thia...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)NC1(CC1)c1ccccc1
Show InChI InChI=1S/C22H25N5O2S/c1-3-16-23-19-17(20(28)26(16)2)24-18(30-19)15-10-7-13-27(15)21(29)25-22(11-12-22)14-8-5-4-6-9-14/h4-6,8-9,15H,3,7,10-13H2,1-2H3,(H,25,29)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273155
PNG
((R)-N-benzyl-1-[(R)-6,8-dimethyl-10-oxo-5,7,8,10-t...)
Show SMILES C[C@@H]1CN(C)Cc2nc3sc(nc3c(=O)n12)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H26N6O2S/c1-14-12-26(2)13-17-24-20-18(21(30)28(14)17)25-22(31-20)27-10-6-9-16(27)19(29)23-11-15-7-4-3-5-8-15/h3-5,7-8,14,16H,6,9-13H2,1-2H3,(H,23,29)/t14-,16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273054
PNG
((R)-2-(7-ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]p...)
Show SMILES CCc1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C18H18N4O3S/c1-2-12-11-15(23)22-17(19-12)26-16(20-22)14-9-6-10-21(14)18(24)25-13-7-4-3-5-8-13/h3-5,7-8,11,14H,2,6,9-10H2,1H3/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273121
PNG
((R)-N-benzyl-1-{6-[(1-methylpiperidin-4-yl)methyl]...)
Show SMILES CN1CCC(Cn2c(nc3sc(nc3c2=O)N2CCC[C@@H]2C(=O)NCc2ccccc2)C(F)(F)F)CC1
Show InChI InChI=1S/C25H29F3N6O2S/c1-32-12-9-17(10-13-32)15-34-22(36)19-21(31-23(34)25(26,27)28)37-24(30-19)33-11-5-8-18(33)20(35)29-14-16-6-3-2-4-7-16/h2-4,6-7,17-18H,5,8-15H2,1H3,(H,29,35)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273044
PNG
(5-(2-fluoropropan-2-yl)-2-[2-(phenylacetyl)pyrazol...)
Show SMILES CC(C)(F)c1nc2sc(nc2c(=O)[nH]1)N1CCCN1C(=O)Cc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273056
PNG
((R)-2-(5-oxo-6,7,8,9-tetrahydro-5H-[1,3,4]thiadiaz...)
Show SMILES O=C(Oc1ccccc1)N1CCC[C@@H]1c1nn2c(nc3CCCCc3c2=O)s1
Show InChI InChI=1S/C20H20N4O3S/c25-18-14-9-4-5-10-15(14)21-19-24(18)22-17(28-19)16-11-6-12-23(16)20(26)27-13-7-2-1-3-8-13/h1-3,7-8,16H,4-6,9-12H2/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273092
PNG
((R)-N-benzyl-1-[6-(1-methylpiperidin-4-yl)-7-oxo-5...)
Show SMILES CN1CCC(CC1)n1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H27F3N6O2S/c1-31-12-9-16(10-13-31)33-21(35)18-20(30-22(33)24(25,26)27)36-23(29-18)32-11-5-8-17(32)19(34)28-14-15-6-3-2-4-7-15/h2-4,6-7,16-17H,5,8-14H2,1H3,(H,28,34)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273195
PNG
((R)-N-benzyl-1-[2-methyl-4-oxo-3-(2,2,2-trifluoroe...)
Show SMILES Cc1nc2ccc(nc2c(=O)n1CC(F)(F)F)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H22F3N5O2/c1-14-27-16-9-10-18(28-19(16)21(32)30(14)13-22(23,24)25)29-11-5-8-17(29)20(31)26-12-15-6-3-2-4-7-15/h2-4,6-7,9-10,17H,5,8,11-13H2,1H3,(H,26,31)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273060
PNG
((R)-N-(2-chlorobenzyl)-2-[5-oxo-7-(propan-2-yl)-5H...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)NCc1ccccc1Cl
Show InChI InChI=1S/C20H22ClN5O2S/c1-12(2)15-10-17(27)26-20(23-15)29-18(24-26)16-8-5-9-25(16)19(28)22-11-13-6-3-4-7-14(13)21/h3-4,6-7,10,12,16H,5,8-9,11H2,1-2H3,(H,22,28)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273029
PNG
(N-{(R)-1-[5-(1-chlorocyclopropyl)-7-oxo-6,7-dihydr...)
Show SMILES C[C@@H](N(C)C(=O)Oc1ccccc1)c1nc2c(nc([nH]c2=O)C2(Cl)CC2)s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273098
PNG
((R)-N-benzyl-1-{6-[3-(N',N'-dimethylamino)propyl]-...)
Show SMILES CN(C)CCCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C23H27F3N6O2S/c1-30(2)11-7-13-32-20(34)17-19(29-21(32)23(24,25)26)35-22(28-17)31-12-6-10-16(31)18(33)27-14-15-8-4-3-5-9-15/h3-5,8-9,16H,6-7,10-14H2,1-2H3,(H,27,33)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273090
PNG
((R)-N-benzyl-1-[6-cyclopropyl-5-methoxymethyl-7-ox...)
Show SMILES COCc1nc2sc(nc2c(=O)n1C1CC1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H25N5O3S/c1-30-13-17-24-20-18(21(29)27(17)15-9-10-15)25-22(31-20)26-11-5-8-16(26)19(28)23-12-14-6-3-2-4-7-14/h2-4,6-7,15-16H,5,8-13H2,1H3,(H,23,28)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273101
PNG
((R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)N[C@H](COC)c1ccccc1)C(F)F
Show InChI InChI=1S/C22H25F2N5O3S/c1-3-28-18(17(23)24)27-20-16(21(28)31)26-22(33-20)29-11-7-10-15(29)19(30)25-14(12-32-2)13-8-5-4-6-9-13/h4-6,8-9,14-15,17H,3,7,10-12H2,1-2H3,(H,25,30)/t14-,15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273062
PNG
(2-{(R)-1-[(3,4-dihydroquinolin-1(2H)-yl)acetyl]pyr...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)CN1CCCc2ccccc12
Show InChI InChI=1S/C23H27N5O2S/c1-15(2)17-13-20(29)28-23(24-17)31-22(25-28)19-10-6-12-27(19)21(30)14-26-11-5-8-16-7-3-4-9-18(16)26/h3-4,7,9,13,15,19H,5-6,8,10-12,14H2,1-2H3/t19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273180
PNG
((R)-1-[5-oxo-7-(propan-2-yl)-5H-[1,3,4]thiadiazolo...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)N1CCC[C@@H]1C(=O)NCc1ccccn1
Show InChI InChI=1S/C19H22N6O2S/c1-12(2)14-10-16(26)25-18(22-14)28-19(23-25)24-9-5-7-15(24)17(27)21-11-13-6-3-4-8-20-13/h3-4,6,8,10,12,15H,5,7,9,11H2,1-2H3,(H,21,27)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273197
PNG
((R)-N-benzyl-1-[2-(1-chlorocyclopropyl)-4-oxo-3,4-...)
Show SMILES ClC1(CC1)c1nc2ccc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273055
PNG
((R)-2-(6-ethyl-7-methyl-5-oxo-5H-[1,3,4]thiadiazol...)
Show SMILES CCc1c(C)nc2sc(nn2c1=O)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C19H20N4O3S/c1-3-14-12(2)20-18-23(17(14)24)21-16(27-18)15-10-7-11-22(15)19(25)26-13-8-5-4-6-9-13/h4-6,8-9,15H,3,7,10-11H2,1-2H3/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273045
PNG
(5-(2-fluoropropan-2-yl)-2-{2-[2-(3-methylphenyl) a...)
Show SMILES Cc1cccc(CC(=O)N2CCCN2c2nc3c(nc([nH]c3=O)C(C)(C)F)s2)c1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273192
PNG
((R)-N-benzyl-1-(7-ethyl-5-oxo-5H-[1,3,4]thiadiazol...)
Show SMILES CCc1cc2sc(nn2c(=O)c1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H22N4O2S/c1-2-14-11-17(25)24-18(12-14)27-20(22-24)23-10-6-9-16(23)19(26)21-13-15-7-4-3-5-8-15/h3-5,7-8,11-12,16H,2,6,9-10,13H2,1H3,(H,21,26)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273083
PNG
((R)-N-benzyl-1-(5,6-diethyl-7-oxo-6,7-dihydro-[1,3...)
Show SMILES CCc1nc2sc(nc2c(=O)n1CC)N1CCCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H27N5O2S/c1-3-17-24-20-18(21(29)26(17)4-2)25-22(30-20)27-13-9-8-12-16(27)19(28)23-14-15-10-6-5-7-11-15/h5-7,10-11,16H,3-4,8-9,12-14H2,1-2H3,(H,23,28)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273165
PNG
((R)-N-benzyl-1-(4-oxo-7-trifluoromethyl-4,5-dihydr...)
Show SMILES FC(F)(F)c1c[nH]c(=O)c2nc(sc12)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273012
PNG
((R)-N-benzyl-2-(5-ethyl-6-methyl-7-oxo-6,7-dihydro...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H23N5O2S/c1-3-15-22-18-16(19(26)24(15)2)23-17(28-18)14-10-7-11-25(14)20(27)21-12-13-8-5-4-6-9-13/h4-6,8-9,14H,3,7,10-12H2,1-2H3,(H,21,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273038
PNG
((R)-2-[6-(2,4-dimethoxybenzyl)-5-ethyl-7-oxo-6,7-d...)
Show SMILES CCc1nc2sc(nc2c(=O)n1Cc1ccc(OC)cc1OC)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C27H28N4O5S/c1-4-22-28-25-23(26(32)31(22)16-17-12-13-19(34-2)15-21(17)35-3)29-24(37-25)20-11-8-14-30(20)27(33)36-18-9-6-5-7-10-18/h5-7,9-10,12-13,15,20H,4,8,11,14,16H2,1-3H3/t20-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273153
PNG
((R)-N-benzyl-1-(6-methyl-10-oxo-5,7,8,10-tetrahydr...)
Show SMILES CN1CCn2c(C1)nc1sc(nc1c2=O)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H24N6O2S/c1-25-10-11-27-16(13-25)23-19-17(20(27)29)24-21(30-19)26-9-5-8-15(26)18(28)22-12-14-6-3-2-4-7-14/h2-4,6-7,15H,5,8-13H2,1H3,(H,22,28)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273201
PNG
((R)-1-(4-oxo-2-propyl-4H-pyrimido[1,2-b]pyridazin-...)
Show SMILES CCCc1cc(=O)n2nc(ccc2n1)N1CCC[C@@H]1C(=O)NC1(CC1)c1ccccc1
Show InChI InChI=1S/C24H27N5O2/c1-2-7-18-16-22(30)29-20(25-18)11-12-21(27-29)28-15-6-10-19(28)23(31)26-24(13-14-24)17-8-4-3-5-9-17/h3-5,8-9,11-12,16,19H,2,6-7,10,13-15H2,1H3,(H,26,31)/t19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273058
PNG
((R)-2-(7-fluoro-5-oxo-5H-[1,3,4]thiadiazolo[2,3-b]...)
Show SMILES Fc1ccc2nc3sc(nn3c(=O)c2c1)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C20H15FN4O3S/c21-12-8-9-15-14(11-12)18(26)25-19(22-15)29-17(23-25)16-7-4-10-24(16)20(27)28-13-5-2-1-3-6-13/h1-3,5-6,8-9,11,16H,4,7,10H2/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273106
PNG
((R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1cc(C)on1)C(F)F
Show InChI InChI=1S/C18H20F2N6O3S/c1-3-25-14(13(19)20)23-16-12(17(25)28)22-18(30-16)26-6-4-5-11(26)15(27)21-8-10-7-9(2)29-24-10/h7,11,13H,3-6,8H2,1-2H3,(H,21,27)/t11-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273126
PNG
((R)-N-benzyl-1-{5-[2-(N',N'-dimethylamino)ethoxy]-...)
Show SMILES CN(C)CCOc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H28N6O3S/c1-26(2)12-13-31-21-25-19-17(20(30)27(21)3)24-22(32-19)28-11-7-10-16(28)18(29)23-14-15-8-5-4-6-9-15/h4-6,8-9,16H,7,10-14H2,1-3H3,(H,23,29)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273048
PNG
((R)-2-(4-oxo-6-trifluoromethyl-4,5-dihydro[1,3]thi...)
Show SMILES FC(F)(F)c1cc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273021
PNG
((R)-2-[5-methyl-7-oxo-6-(tetrahydro-2H-pyran-4-yl)...)
Show SMILES Cc1nc2sc(nc2c(=O)n1C1CCOCC1)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C22H24N4O4S/c1-14-23-20-18(21(27)26(14)15-9-12-29-13-10-15)24-19(31-20)17-8-5-11-25(17)22(28)30-16-6-3-2-4-7-16/h2-4,6-7,15,17H,5,8-13H2,1H3/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273064
PNG
((R)-N-((R)-indan-1-yl)-2-[5-oxo-7-(propan-2-yl)-5H...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)N[C@@H]1CCc2ccccc12
Show InChI InChI=1S/C22H25N5O2S/c1-13(2)17-12-19(28)27-22(24-17)30-20(25-27)18-8-5-11-26(18)21(29)23-16-10-9-14-6-3-4-7-15(14)16/h3-4,6-7,12-13,16,18H,5,8-11H2,1-2H3,(H,23,29)/t16-,18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273100
PNG
((R)-N-[(R)-cyclopropyl(phenyl)methyl]-1-(5-difluor...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)N[C@H](C1CC1)c1ccccc1)C(F)F
Show InChI InChI=1S/C23H25F2N5O2S/c1-2-29-19(18(24)25)28-21-17(22(29)32)27-23(33-21)30-12-6-9-15(30)20(31)26-16(14-10-11-14)13-7-4-3-5-8-13/h3-5,7-8,14-16,18H,2,6,9-12H2,1H3,(H,26,31)/t15-,16+/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273059
PNG
((R)-N-benzyl-2-[5-oxo-7-(propan-2-yl)-5H-[1,3,4]th...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H23N5O2S/c1-13(2)15-11-17(26)25-20(22-15)28-18(23-25)16-9-6-10-24(16)19(27)21-12-14-7-4-3-5-8-14/h3-5,7-8,11,13,16H,6,9-10,12H2,1-2H3,(H,21,27)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273069
PNG
(2-(5-oxo-7-propyl-5H-[1,3,4]thiadiazolo[3,2-a]pyri...)
Show SMILES CCCc1cc(=O)n2nc(sc2n1)N1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C18H19N5O3S/c1-2-7-13-12-15(24)23-16(19-13)27-17(20-23)21-10-6-11-22(21)18(25)26-14-8-4-3-5-9-14/h3-5,8-9,12H,2,6-7,10-11H2,1H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273202
PNG
((R)-N-benzyl-1-[4-oxo-2-(propan-2-yl)-4H-pyrimido[...)
Show SMILES CC(C)c1cc(=O)n2nc(ccc2n1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H25N5O2/c1-15(2)17-13-21(28)27-19(24-17)10-11-20(25-27)26-12-6-9-18(26)22(29)23-14-16-7-4-3-5-8-16/h3-5,7-8,10-11,13,15,18H,6,9,12,14H2,1-2H3,(H,23,29)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273015
PNG
((R)-5-ethyl-2-{1-[((R)-indan-1-yl)aminocarbonyl]py...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)N[C@@H]1CCc2ccccc12
Show InChI InChI=1S/C22H25N5O2S/c1-3-17-24-20-18(21(28)26(17)2)25-19(30-20)16-9-6-12-27(16)22(29)23-15-11-10-13-7-4-5-8-14(13)15/h4-5,7-8,15-16H,3,6,9-12H2,1-2H3,(H,23,29)/t15-,16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273184
PNG
((R)-1-(7-ethyl-6-fluoro-5-oxo-5H-[1,3,4]thiadiazol...)
Show SMILES CCc1nc2sc(nn2c(=O)c1F)N1CCC[C@@H]1C(=O)NCc1cc(C)ccn1
Show InChI InChI=1S/C19H21FN6O2S/c1-3-13-15(20)17(28)26-18(23-13)29-19(24-26)25-8-4-5-14(25)16(27)22-10-12-9-11(2)6-7-21-12/h6-7,9,14H,3-5,8,10H2,1-2H3,(H,22,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273160
PNG
((2R,3R)-3-amino-N-benzyl-1-(6-methyl-7-oxo-5-pheny...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CC[C@@H](N)[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O2S/c1-29-20(16-10-6-3-7-11-16)28-22-18(23(29)32)27-24(33-22)30-13-12-17(25)19(30)21(31)26-14-15-8-4-2-5-9-15/h2-11,17,19H,12-14,25H2,1H3,(H,26,31)/t17-,19-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273200
PNG
((R)-N-benzyl-1-(4-oxo-2-phenyl-4H-pyrimido[1,2-b]p...)
Show SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1ccc2nc(cc(=O)n2n1)-c1ccccc1
Show InChI InChI=1S/C25H23N5O2/c31-24-16-20(19-10-5-2-6-11-19)27-22-13-14-23(28-30(22)24)29-15-7-12-21(29)25(32)26-17-18-8-3-1-4-9-18/h1-6,8-11,13-14,16,21H,7,12,15,17H2,(H,26,32)/t21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273011
PNG
((R)-2-{6-methyl-5-[(morpholin-4-yl)methyl]-7-oxo-6...)
Show SMILES Cn1c(CN2CCOCC2)nc2sc(nc2c1=O)[C@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C23H27N5O4S/c1-26-18(14-27-10-12-31-13-11-27)24-21-19(22(26)29)25-20(33-21)17-8-5-9-28(17)23(30)32-15-16-6-3-2-4-7-16/h2-4,6-7,17H,5,8-15H2,1H3/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273108
PNG
((R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1nccs1)C(F)F
Show InChI InChI=1S/C17H18F2N6O2S2/c1-2-24-13(12(18)19)23-15-11(16(24)27)22-17(29-15)25-6-3-4-9(25)14(26)21-8-10-20-5-7-28-10/h5,7,9,12H,2-4,6,8H2,1H3,(H,21,26)/t9-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273196
PNG
((R)-N-benzyl-1-(3-methyl-4-oxo-2-trifluoromethyl-3...)
Show SMILES Cn1c(nc2ccc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N5O2/c1-28-19(31)17-14(26-20(28)21(22,23)24)9-10-16(27-17)29-11-5-8-15(29)18(30)25-12-13-6-3-2-4-7-13/h2-4,6-7,9-10,15H,5,8,11-12H2,1H3,(H,25,30)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273052
PNG
((R)-2-[5-oxo-7-(propan-2-yl)-5H-[1,3,4]thiadiazolo...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C20H22N4O3S/c1-13(2)15-11-17(25)24-19(21-15)28-18(22-24)16-9-6-10-23(16)20(26)27-12-14-7-4-3-5-8-14/h3-5,7-8,11,13,16H,6,9-10,12H2,1-2H3/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273067
PNG
((R)-2-(6,7-dimethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,...)
Show SMILES Cc1nc2sc(nn2c(=O)c1C)[C@H]1CCCN1C(=O)NC(C)(C)c1ccccc1
Show InChI InChI=1S/C21H25N5O2S/c1-13-14(2)22-20-26(18(13)27)24-17(29-20)16-11-8-12-25(16)19(28)23-21(3,4)15-9-6-5-7-10-15/h5-7,9-10,16H,8,11-12H2,1-4H3,(H,23,28)/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273065
PNG
(2-[(R)-1-(2,3-dihydro-indole-1-carbonyl)pyrrolidin...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)N1CCc2ccccc12
Show InChI InChI=1S/C21H23N5O2S/c1-13(2)15-12-18(27)26-20(22-15)29-19(23-26)17-8-5-10-24(17)21(28)25-11-9-14-6-3-4-7-16(14)25/h3-4,6-7,12-13,17H,5,8-11H2,1-2H3/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273171
PNG
((R)-N-benzyl-1-(5-oxo-7-propyl-5H-[1,3,4]thiadiazo...)
Show SMILES CCCc1cc(=O)n2nc(sc2n1)N1CCCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H25N5O2S/c1-2-8-16-13-18(27)26-20(23-16)29-21(24-26)25-12-7-6-11-17(25)19(28)22-14-15-9-4-3-5-10-15/h3-5,9-10,13,17H,2,6-8,11-12,14H2,1H3,(H,22,28)/t17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273050
PNG
(2-[(R)-1-(phenylacetyl)pyrrolidin-2-yl]-7-(propan-...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)Cc1ccccc1
Show InChI InChI=1S/C20H22N4O2S/c1-13(2)15-12-18(26)24-20(21-15)27-19(22-24)16-9-6-10-23(16)17(25)11-14-7-4-3-5-8-14/h3-5,7-8,12-13,16H,6,9-11H2,1-2H3/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273017
PNG
((R)-2-(5-ethyl-6-methyl-7-oxo-6,7-dihydro[1,3]thia...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)NC(C)(C)c1ccccc1
Show InChI InChI=1S/C22H27N5O2S/c1-5-16-23-19-17(20(28)26(16)4)24-18(30-19)15-12-9-13-27(15)21(29)25-22(2,3)14-10-7-6-8-11-14/h6-8,10-11,15H,5,9,12-13H2,1-4H3,(H,25,29)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273142
PNG
((R)-N-benzyl-1-[7-oxo-5-(2,2,2-trifluoroethoxy)-6,...)
Show SMILES FC(F)(F)COc1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273107
PNG
((R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1cc(C)nn1C)C(F)F
Show InChI InChI=1S/C19H23F2N7O2S/c1-4-27-15(14(20)21)24-17-13(18(27)30)23-19(31-17)28-7-5-6-12(28)16(29)22-9-11-8-10(2)25-26(11)3/h8,12,14H,4-7,9H2,1-3H3,(H,22,29)/t12-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273053
PNG
(2-[(R)-1-(2-phenoxyacetyl)pyrrolidin-2-yl]-7-(prop...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)COc1ccccc1
Show InChI InChI=1S/C20H22N4O3S/c1-13(2)15-11-17(25)24-20(21-15)28-19(22-24)16-9-6-10-23(16)18(26)12-27-14-7-4-3-5-8-14/h3-5,7-8,11,13,16H,6,9-10,12H2,1-2H3/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273172
PNG
((R)-1-(7-methyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]...)
Show SMILES Cc1cc(=O)n2nc(sc2n1)N1CCC[C@@H]1C(=O)NC(C)(C)c1ccccc1
Show InChI InChI=1S/C20H23N5O2S/c1-13-12-16(26)25-18(21-13)28-19(23-25)24-11-7-10-15(24)17(27)22-20(2,3)14-8-5-4-6-9-14/h4-6,8-9,12,15H,7,10-11H2,1-3H3,(H,22,27)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273018
PNG
((R)-2-(5-ethyl-6-methyl-7-oxo-6,7-dihydro[1,3]thia...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)[C@H]1CCCN1C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C21H25N5O2S/c1-4-16-23-19-17(20(27)25(16)3)24-18(29-19)15-11-8-12-26(15)21(28)22-13(2)14-9-6-5-7-10-14/h5-7,9-10,13,15H,4,8,11-12H2,1-3H3,(H,22,28)/t13-,15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273176
PNG
((R)-N-benzyl-4-(7-ethyl-5-oxo-5H-[1,3,4]thiadiazol...)
Show SMILES CCc1cc(=O)n2nc(sc2n1)N1CCOC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H21N5O3S/c1-2-14-10-16(25)24-18(21-14)28-19(22-24)23-8-9-27-12-15(23)17(26)20-11-13-6-4-3-5-7-13/h3-7,10,15H,2,8-9,11-12H2,1H3,(H,20,26)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273066
PNG
((R)-2-(6,7-dimethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,...)
Show SMILES C[C@@H](NC(=O)N1CCC[C@@H]1c1nn2c(nc(C)c(C)c2=O)s1)c1ccccc1
Show InChI InChI=1S/C20H23N5O2S/c1-12-13(2)22-20-25(18(12)26)23-17(28-20)16-10-7-11-24(16)19(27)21-14(3)15-8-5-4-6-9-15/h4-6,8-9,14,16H,7,10-11H2,1-3H3,(H,21,27)/t14-,16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273179
PNG
((R)-N-benzyl-1-(7-ethyl-6-fluoro-5-oxo-5H-[1,3,4]t...)
Show SMILES CCc1nc2sc(nn2c(=O)c1F)N1CC(F)(F)C[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H18F3N5O2S/c1-2-12-14(20)16(29)27-17(24-12)30-18(25-27)26-10-19(21,22)8-13(26)15(28)23-9-11-6-4-3-5-7-11/h3-7,13H,2,8-10H2,1H3,(H,23,28)/t13-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273188
PNG
((R)-1-(7-ethyl-6-fluoro-5-oxo-5H-[1,3,4]thiadiazol...)
Show SMILES CCc1nc2sc(nn2c(=O)c1F)N1CCC[C@@H]1C(=O)NCc1cnc(C)cn1
Show InChI InChI=1S/C18H20FN7O2S/c1-3-12-14(19)16(28)26-17(23-12)29-18(24-26)25-6-4-5-13(25)15(27)22-9-11-8-20-10(2)7-21-11/h7-8,13H,3-6,9H2,1-2H3,(H,22,27)/t13-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273051
PNG
(2-{(R)-1-[2-(4-fluorophenyl)acetyl]pyrrolidin-2-yl...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C20H21FN4O2S/c1-12(2)15-11-18(27)25-20(22-15)28-19(23-25)16-4-3-9-24(16)17(26)10-13-5-7-14(21)8-6-13/h5-8,11-12,16H,3-4,9-10H2,1-2H3/t16-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273102
PNG
((R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-...)
Show SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)N[C@@H](c1ccccc1)C(F)(F)F)C(F)F
Show InChI InChI=1S/C21H20F5N5O2S/c1-2-30-16(15(22)23)29-18-13(19(30)33)27-20(34-18)31-10-6-9-12(31)17(32)28-14(21(24,25)26)11-7-4-3-5-8-11/h3-5,7-8,12,14-15H,2,6,9-10H2,1H3,(H,28,32)/t12-,14+/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273068
PNG
((R)-2-(6,7-dimethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,...)
Show SMILES Cc1nc2sc(nn2c(=O)c1C)[C@H]1CCCN1C(=O)Nc1csc2ncccc12
Show InChI InChI=1S/C19H18N6O2S2/c1-10-11(2)21-19-25(17(10)26)23-16(29-19)14-6-4-8-24(14)18(27)22-13-9-28-15-12(13)5-3-7-20-15/h3,5,7,9,14H,4,6,8H2,1-2H3,(H,22,27)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273183
PNG
((1SR,2RS,5RS)-N-benzyl-3-(7-methyl-5-oxo-5H-[1,3,4...)
Show SMILES Cc1cc(=O)n2nc(sc2n1)N1C[C@@H]2C[C@@H]2[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H19N5O2S/c1-11-7-15(25)24-18(21-11)27-19(22-24)23-10-13-8-14(13)16(23)17(26)20-9-12-5-3-2-4-6-12/h2-7,13-14,16H,8-10H2,1H3,(H,20,26)/t13-,14-,16+/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273061
PNG
((R)-2-[5-oxo-7-(propan-2-yl)-5H-[1,3,4]thiadiazolo...)
Show SMILES CC(C)c1cc(=O)n2nc(sc2n1)[C@H]1CCCN1C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H21N5O2S/c1-12(2)14-11-16(25)24-19(21-14)27-17(22-24)15-9-6-10-23(15)18(26)20-13-7-4-3-5-8-13/h3-5,7-8,11-12,15H,6,9-10H2,1-2H3,(H,20,26)/t15-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273013
PNG
((R)-N-(2-chlorobenzyl)-2-[7-oxo-6-(propan-2-yl)-5-...)
Show SMILES CC(C)n1c(nc2sc(nc2c1=O)[C@H]1CCCN1C(=O)NCc1ccccc1Cl)C(F)(F)F
Show InChI InChI=1S/C21H21ClF3N5O2S/c1-11(2)30-18(31)15-17(28-19(30)21(23,24)25)33-16(27-15)14-8-5-9-29(14)20(32)26-10-12-6-3-4-7-13(12)22/h3-4,6-7,11,14H,5,8-10H2,1-2H3,(H,26,32)/t14-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273185
PNG
((R)-N-(7-methyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]...)
Show SMILES Cc1cc(=O)n2nc(sc2n1)N1CCC[C@@H]1C(=O)N[C@@H]1CCCc2ccccc12
Show InChI InChI=1S/C21H23N5O2S/c1-13-12-18(27)26-20(22-13)29-21(24-26)25-11-5-10-17(25)19(28)23-16-9-4-7-14-6-2-3-8-15(14)16/h2-3,6,8,12,16-17H,4-5,7,9-11H2,1H3,(H,23,28)/t16-,17-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273187
PNG
((R)-1-(7-ethyl-6-fluoro-5-oxo-5H-[1,3,4]thiadiazol...)
Show SMILES CCc1nc2sc(nn2c(=O)c1F)N1CCC[C@@H]1C(=O)NCc1ncccn1
Show InChI InChI=1S/C17H18FN7O2S/c1-2-10-13(18)15(27)25-16(22-10)28-17(23-25)24-8-3-5-11(24)14(26)21-9-12-19-6-4-7-20-12/h4,6-7,11H,2-3,5,8-9H2,1H3,(H,21,26)/t11-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
n/an/a 1.10E+4n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273189
PNG
((R)-1-(7-ethyl-6-fluoro-5-oxo-5H-[1,3,4]thiadiazol...)
Show SMILES CCc1nc2sc(nn2c(=O)c1F)N1CCC[C@@H]1C(=O)NCc1nnc2ccccn12
Show InChI InChI=1S/C19H19FN8O2S/c1-2-11-15(20)17(30)28-18(22-11)31-19(25-28)26-9-5-6-12(26)16(29)21-10-14-24-23-13-7-3-4-8-27(13)14/h3-4,7-8,12H,2,5-6,9-10H2,1H3,(H,21,29)/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
n/an/a 3.20E+4n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%