BindingDB logo
myBDB logout

Patent code US10065973

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273210
PNG
(5-Amino-3-[(2R,3S,5S)-5-(hydroxymethyl)-3-[(S)-hyd...)
Show SMILES Nc1nc2n([C@@H]3O[C@H](CO)C[C@H]3C(O)c3ccccn3)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.25E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273226
PNG
(5-Amino-3-[(2R,3S,5S)-3-(1-hydroxy-1-methyl-ethyl)...)
Show SMILES CC[C@H](O)[C@@H]1C[C@H]([C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O)C(C)(C)O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 3.00E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273222
PNG
(US10065973, Example 17 | [(1S)-1-[(2S,4S,5R)-5-(5-...)
Show SMILES CC[C@H](OC(C)=O)[C@@H]1C[C@@H]([C@@H](C)O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.50E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273205
PNG
(US10065973, Example 2-A)
Show SMILES Nc1nc2n([C@@H]3O[C@H](CO)C[C@H]3C(O)C3CC3)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.56E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273219
PNG
(5-Amino-3-[(2R,3S,5S)-3-[(1R)-1-benzyloxyethyl]-5-...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@@H](C)OCc2ccccc2)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 6.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273223
PNG
(US10065973, Example 18-A | US10065973, Example 18-...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@H](O)c2ccccc2)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 9.70E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273204
PNG
(US10065973, Example 1-B)
Show SMILES CC(O)[C@@H]1C[C@@H](CO)O[C@H]1n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 3.90E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273208
PNG
(US10065973, Example 5-A)
Show SMILES COc1ccccc1C(O)[C@@H]1C[C@@H](CO)O[C@H]1n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.11E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273211
PNG
(5-Amino-3-[(2R,3S,5S)-5-(hydroxymethyl)-3-(1-hydro...)
Show SMILES CC(C)(O)[C@@H]1C[C@@H](CO)O[C@H]1n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.30E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273212
PNG
(US10065973, Example 9-A | US10065973, Example 9-B)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@@H](C)OC(C)=O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O.CC[C@H](O)[C@@H]1C[C@@H]([C@H](C)OC(C)=O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 9.30E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273216
PNG
(US10065973, Example 11 | [(1R)-1-[(2R,3S,5S)-2-(5-...)
Show SMILES CCOC(=O)O[C@H](C)[C@@H]1C[C@H](O[C@H]1n1c2nc(N)[nH]c(=O)c2sc1=O)[C@@H](O)CC
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.60E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273218
PNG
(5-Amino-3-[(2R,3S,5S)-5-[(1S)-1-hydroxypropyl]-3-[...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@@H](C)OC)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 3.60E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273220
PNG
(3-[(2R,3S,5S)-3-[(1R)-1-Allyloxyethyl]-5-[(1S)-1-h...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@@H](C)OCC=C)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 6.80E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273223
PNG
(US10065973, Example 18-A | US10065973, Example 18-...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@H](O)c2ccccc2)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.04E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273206
PNG
(US10065973, Example 3-A)
Show SMILES CCC(O)[C@@H]1C[C@@H](CO)O[C@H]1n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.11E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273207
PNG
(US10065973, Example 4-A)
Show SMILES Nc1nc2n([C@@H]3O[C@H](CO)C[C@H]3C(O)c3ccccc3)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.05E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273209
PNG
(US10065973, Example 6-A)
Show SMILES Nc1nc2n([C@@H]3O[C@H](CO)C[C@H]3C(O)c3ccccc3Cl)c(=O)sc2c(=O)[nH]1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 7.90E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273214
PNG
(US10065973, Example 10-A | US10065973, Example 10-...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@@H](C)O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O.CC[C@H](O)[C@@H]1C[C@@H]([C@H](C)O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 3.50E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273217
PNG
(US10065973, Example 12 | [(1R)-1-[(2R,3S,5S)-2-(5-...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@@H](C)OC(=O)c2ccccc2)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 6.50E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273221
PNG
(5-Amino-3-[(2R,3S,5S)-5-[(1S)-1-hydroxypropyl]-3-[...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@H](C)OC)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 3.50E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273214
PNG
(US10065973, Example 10-A | US10065973, Example 10-...)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@@H](C)O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O.CC[C@H](O)[C@@H]1C[C@@H]([C@H](C)O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 2.70E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273225
PNG
(US10065973, Example 19 | [1-[(2R,3S,5S)-2-(5-Amino...)
Show SMILES CC[C@H](O)[C@@H]1C[C@H]([C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O)C(C)(C)OC(C)=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 1.90E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM273212
PNG
(US10065973, Example 9-A | US10065973, Example 9-B)
Show SMILES CC[C@H](O)[C@@H]1C[C@@H]([C@@H](C)OC(C)=O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O.CC[C@H](O)[C@@H]1C[C@@H]([C@H](C)OC(C)=O)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/an/an/a 8.40E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK293-Blue-hTLR7 cells were incubated at a density of 250,000-450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Modif...


US Patent US10065973 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%