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Patent code US10071110

Compile Data Set for Download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50001103
PNG
((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Show SMILES Nc1ncnc2n(CCOCP(O)(O)=O)cnc12
Show InChI InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
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n/an/an/an/a 5.50E+4n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM31915
PNG
(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM275786
PNG
(US10071110, Compound 1-O-octadecylpropanediol-2-cC...)
Show SMILES CCCCCCCCCCCCCCCCOCC(CO)OP1(=O)COC(CO1)n1ccc(N)nc1=O
Show InChI InChI=1S/C26H48N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-33-20-23(19-30)36-37(32)22-34-25(21-35-37)29-17-16-24(27)28-26(29)31/h16-17,23,25,30H,2-15,18-22H2,1H3,(H2,27,28,31)
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n/an/an/an/a 8n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275776
PNG
(US10071110, Compound 1-O-octadecylpropanediol-3-cC...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C29H54N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21-35-22-18-23-37-39(34)26-36-27(25-38-39)24-32-20-19-28(30)31-29(32)33/h19-20,27H,2-18,21-26H2,1H3,(H2,30,31,33)
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n/an/an/an/a 3.00E+5n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275777
PNG
(US10071110, Compound 1-O-octadecylethanediol-2-CDV)
Show SMILES CCCCCCCCCCCCCCCCCCOCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
Show InChI InChI=1S/C28H54N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-36-21-22-38-39(34,35)25-37-26(24-32)23-31-19-18-27(29)30-28(31)33/h18-19,26,32H,2-17,20-25H2,1H3,(H,34,35)(H2,29,30,33)
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n/an/an/an/a>1n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275779
PNG
(US10071110, Compound Hexadecyl-cCDV)
Show SMILES CCCCCCCCCCCCCCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C24H44N3O5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-31-33(29)21-30-22(20-32-33)19-27-17-16-23(25)26-24(27)28/h16-17,22H,2-15,18-21H2,1H3,(H2,25,26,28)
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n/an/an/an/a 40n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275781
PNG
(US10071110, Compound 1-O-octadecyl-sn-glycero-3-AD...)
Show SMILES CCCCCCCCCCCCCCCCCCOC[C@H](CO)OP(O)(=O)COCCn1cnc2c(N)ncnc12
Show InChI InChI=1S/C29H54N5O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-38-22-26(21-35)40-41(36,37)25-39-20-18-34-24-33-27-28(30)31-23-32-29(27)34/h23-24,26,35H,2-22,25H2,1H3,(H,36,37)(H2,30,31,32)/t26-/m0/s1
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n/an/an/an/a 210n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
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n/an/an/an/a 2.10E+3n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
Show InChI InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
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n/an/an/an/a 970n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM275773
PNG
(US10071110, Compound 1-O-hexadecylpropanediol-3-CD...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
Show InChI InChI=1S/C27H52N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-35-20-16-21-37-38(33,34)24-36-25(23-31)22-30-18-17-26(28)29-27(30)32/h17-18,25,31H,2-16,19-24H2,1H3,(H,33,34)(H2,28,29,32)
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n/an/an/an/a 400n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM275776
PNG
(US10071110, Compound 1-O-octadecylpropanediol-3-cC...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C29H54N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21-35-22-18-23-37-39(34)26-36-27(25-38-39)24-32-20-19-28(30)31-29(32)33/h19-20,27H,2-18,21-26H2,1H3,(H2,30,31,33)
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n/an/an/an/a 330n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275778
PNG
(US10071110, Compound 1-O-octadecylethanediol-2-cCD...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C28H52N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-34-21-22-36-38(33)25-35-26(24-37-38)23-31-19-18-27(29)30-28(31)32/h18-19,26H,2-17,20-25H2,1H3,(H2,29,30,32)
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n/an/an/an/a 3.00E+5n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
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n/an/an/an/a 1.80E+3n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
Show InChI InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
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n/an/an/an/a 720n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM275783
PNG
(US10071110, Compound HDP-ADV)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)COCn1cnc2c(N)ncnc12
Show InChI InChI=1S/C26H48N5O5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-34-18-16-19-36-37(32,33)23-35-22-31-21-30-24-25(27)28-20-29-26(24)31/h20-21H,2-19,22-23H2,1H3,(H,32,33)(H2,27,28,29)
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n/an/an/an/a 0.100n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Preliminary experiments in the inhibition of HIV-1 replication by invention compounds were performed as follows. Drug assays were carried out as prev...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C27H50N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-33-20-16-21-35-37(32)24-34-25(23-36-37)22-30-18-17-26(28)29-27(30)31/h17-18,25H,2-16,19-24H2,1H3,(H2,28,29,31)
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n/an/an/an/a 30n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM50001103
PNG
((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Show SMILES Nc1ncnc2n(CCOCP(O)(O)=O)cnc12
Show InChI InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
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n/an/an/an/a 1.60E+4n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Preliminary experiments in the inhibition of HIV-1 replication by invention compounds were performed as follows. Drug assays were carried out as prev...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
Show InChI InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
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n/an/an/an/a 2.10E+3n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM275775
PNG
(US10071110, Compound 1-O-octadecylpropanediol-3-CD...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
Show InChI InChI=1S/C29H56N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21-37-22-18-23-39-40(35,36)26-38-27(25-33)24-32-20-19-28(30)31-29(32)34/h19-20,27,33H,2-18,21-26H2,1H3,(H,35,36)(H2,30,31,34)
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n/an/an/an/a 3n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM275785
PNG
(US10071110, Compound 1-O-octadecylpropanediol-2-CD...)
Show SMILES CCCCCCCCCCCCCCCCOCC(CO)OP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
Show InChI InChI=1S/C27H52N3O8P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-36-22-25(21-32)38-39(34,35)23-37-24(20-31)19-30-17-16-26(28)29-27(30)33/h16-17,24-25,31-32H,2-15,18-23H2,1H3,(H,34,35)(H2,28,29,33)
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n/an/an/an/a 2n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275775
PNG
(US10071110, Compound 1-O-octadecylpropanediol-3-CD...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
Show InChI InChI=1S/C29H56N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21-37-22-18-23-39-40(35,36)26-38-27(25-33)24-32-20-19-28(30)31-29(32)34/h19-20,27,33H,2-18,21-26H2,1H3,(H,35,36)(H2,30,31,34)
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n/an/an/an/a 3.00E+4n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C27H50N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-33-20-16-21-35-37(32)24-34-25(23-36-37)22-30-18-17-26(28)29-27(30)31/h17-18,25H,2-16,19-24H2,1H3,(H2,28,29,31)
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n/an/an/an/a 110n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C27H50N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-33-20-16-21-35-37(32)24-34-25(23-36-37)22-30-18-17-26(28)29-27(30)31/h17-18,25H,2-16,19-24H2,1H3,(H2,28,29,31)
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n/an/an/an/a<30n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Human herpes virus 5 capsid protein P40


(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
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n/an/an/an/a 450n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Antiviral assays for HCMV DNA were carried out by DNA hybridization as reported by Dankner, W. M., Scholl, D., Stanat, S. C., Martin, M., Souke, R. L...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Human herpes virus 5 capsid protein P40


(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
Show InChI InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
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n/an/an/an/a 470n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Antiviral assays for HCMV DNA were carried out by DNA hybridization as reported by Dankner, W. M., Scholl, D., Stanat, S. C., Martin, M., Souke, R. L...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Human herpes virus 5 capsid protein P40


(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C27H50N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-33-20-16-21-35-37(32)24-34-25(23-36-37)22-30-18-17-26(28)29-27(30)31/h17-18,25H,2-16,19-24H2,1H3,(H2,28,29,31)
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n/an/an/an/a 0.5n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Antiviral assays for HCMV DNA were carried out by DNA hybridization as reported by Dankner, W. M., Scholl, D., Stanat, S. C., Martin, M., Souke, R. L...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
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n/an/an/an/a 460n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C27H50N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-33-20-16-21-35-37(32)24-34-25(23-36-37)22-30-18-17-26(28)29-27(30)31/h17-18,25H,2-16,19-24H2,1H3,(H2,28,29,31)
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n/an/an/an/a 3.00E+5n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Human herpes virus 5 capsid protein P40


(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
BDBM50001103
PNG
((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Show SMILES Nc1ncnc2n(CCOCP(O)(O)=O)cnc12
Show InChI InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
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n/an/an/an/a 5.50E+4n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Antiviral assays for HCMV DNA were carried out by DNA hybridization as reported by Dankner, W. M., Scholl, D., Stanat, S. C., Martin, M., Souke, R. L...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275773
PNG
(US10071110, Compound 1-O-hexadecylpropanediol-3-CD...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
Show InChI InChI=1S/C27H52N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-35-20-16-21-37-38(33,34)24-36-25(23-31)22-30-18-17-26(28)29-27(30)32/h17-18,25,31H,2-16,19-24H2,1H3,(H,33,34)(H2,28,29,32)
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n/an/an/an/a 2.00E+3n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275780
PNG
(US10071110, Compound 1-O-hexadecylpropanediol-3-AD...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP(O)(=O)COCCn1cnc2c(N)ncnc12
Show InChI InChI=1S/C29H54N5O5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-37-21-18-22-39-40(35,36)26-38-23-19-34-25-33-27-28(30)31-24-32-29(27)34/h24-25H,2-23,26H2,1H3,(H,35,36)(H2,30,31,32)
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n/an/an/an/a 100n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
HIV-1 protease


(Human immunodeficiency virus)
BDBM50002692
PNG
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
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n/an/an/an/a 7n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Preliminary experiments in the inhibition of HIV-1 replication by invention compounds were performed as follows. Drug assays were carried out as prev...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
Show InChI InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
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n/an/an/an/a 470n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%