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Patent code US10071974

Compile Data Set for Download or QSAR
Found 169 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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89.2n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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194n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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218n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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522n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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8.62E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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8.62E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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8.69E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 3


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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8.71E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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9.01E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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9.45E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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9.48E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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9.60E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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9.63E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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9.63E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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9.75E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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9.75E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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9.77E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 5


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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9.86E+3n/an/an/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275893
PNG
(US10071974, Example 4)
Show SMILES CC(C)(COc1cnccc1C(F)(F)F)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C16H22F3N3O3/c1-15(2,22-14(23)11-7-21-5-6-24-9-11)10-25-13-8-20-4-3-12(13)16(17,18)19/h3-4,8,11,21H,5-7,9-10H2,1-2H3,(H,22,23)
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n/an/an/an/a 272n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275903
PNG
(US10071974, Example 14)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1nc2ccc(Cl)cc2[nH]1
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n/an/an/an/a 796n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275915
PNG
(US10071974, Example 26 | US10071974, Example 27 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-8-9-18-10-11-23-14)15-12-6-4-5-7-13(12)21(3)20-15/h4-7,14,18H,8-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 61.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275915
PNG
(US10071974, Example 26 | US10071974, Example 27 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-8-9-18-10-11-23-14)15-12-6-4-5-7-13(12)21(3)20-15/h4-7,14,18H,8-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 48.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275921
PNG
(US10071974, Example 32)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-6-13-12(9-18-20(11)13)16(2,3)19-15(21)14-10-17-7-8-22-14/h4-6,9,14,17H,7-8,10H2,1-3H3,(H,19,21)/t14-/m0/s1
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n/an/an/an/a 10.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275928
PNG
(US10071974, Example 39)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)[C@H]1CNCCO1
Show InChI InChI=1S/C18H23N3O2/c1-12-13-6-4-5-7-14(13)15(10-20-12)18(2,3)21-17(22)16-11-19-8-9-23-16/h4-7,10,16,19H,8-9,11H2,1-3H3,(H,21,22)/t16-/m1/s1
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n/an/an/an/a 180n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275929
PNG
(US10071974, Example 40 | US10071974, Example 41 | ...)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-15-6-4-5-7-16(15)17(11-21-13)19(2,3)22-18(23)14-10-20-8-9-24-12-14/h4-7,11,14,20H,8-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 0.800n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275939
PNG
(US10071974, Example 50 | US10071974, Example 51 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-12-14-6-4-5-7-15(14)17(21-13)19(2,3)22-18(23)16-8-9-20-10-11-24-16/h4-7,12,16,20H,8-11H2,1-3H3,(H,22,23)
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n/an/an/an/a 105n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275942
PNG
(US10071974, Example 53)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21N3O3/c1-10-5-4-6-11-13(10)22-19-14(11)16(2,3)18-15(20)12-9-17-7-8-21-12/h4-6,12,17H,7-9H2,1-3H3,(H,18,20)/t12-/m0/s1
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n/an/an/an/a 13.6n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275946
PNG
(US10071974, Example 57)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
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n/an/an/an/a 2.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275960
PNG
(US10071974, Example 71)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C15H18ClN3O3/c1-15(2,18-14(20)11-8-17-6-7-21-11)13-9-4-3-5-10(16)12(9)22-19-13/h3-5,11,17H,6-8H2,1-2H3,(H,18,20)/t11-/m0/s1
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n/an/an/an/a 35.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275961
PNG
(US10071974, Example 72 | US10071974, Example 73 | ...)
Show SMILES [H][N](C)(C(=O)C1CNCCOC1)C(C)(C)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C17H23ClN3O3/c1-17(2,15-12-5-4-6-13(18)14(12)24-20-15)21(3)16(22)11-9-19-7-8-23-10-11/h4-6,11,19,21H,7-10H2,1-3H3
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n/an/an/an/a 17.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275968
PNG
(US10071974, Example 79)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21ClN4O2/c1-16(2,19-15(22)12-9-18-7-8-23-12)14-10-5-4-6-11(17)13(10)21(3)20-14/h4-6,12,18H,7-9H2,1-3H3,(H,19,22)/t12-/m0/s1
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n/an/an/an/a 2.20n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275976
PNG
(US10071974, Example 87)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1n[nH]c2c(F)cccc12
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n/an/an/an/a 13.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275995
PNG
(US10071974, Example 106)
Show SMILES Cc1nc2ccccn2c1C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-14(20-8-5-4-6-13(20)18-11)16(2,3)19-15(21)12-10-17-7-9-22-12/h4-6,8,12,17H,7,9-10H2,1-3H3,(H,19,21)/t12-/m0/s1
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n/an/an/an/a 230n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275999
PNG
(US10071974, Example 110 | US10071974, Example 111)
Show SMILES Cc1cccn2c(ncc12)C(C)(NC(=O)[C@@H]1CNCCO1)C1CC1
Show InChI InChI=1S/C18H24N4O2/c1-12-4-3-8-22-14(12)10-20-17(22)18(2,13-5-6-13)21-16(23)15-11-19-7-9-24-15/h3-4,8,10,13,15,19H,5-7,9,11H2,1-2H3,(H,21,23)/t15-,18?/m0/s1
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n/an/an/an/a 290n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276001
PNG
(US10071974, Example 112 | US10071974, Example 113)
Show SMILES CC(C)CC(C)(NC(=O)[C@@H]1CNCCO1)c1ncc2c(C)cccn12
Show InChI InChI=1S/C19H28N4O2/c1-13(2)10-19(4,22-17(24)16-12-20-7-9-25-16)18-21-11-15-14(3)6-5-8-23(15)18/h5-6,8,11,13,16,20H,7,9-10,12H2,1-4H3,(H,22,24)/t16-,19?/m0/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276017
PNG
(US10071974, Example 128 | US10071974, Example 129 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-8-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-10-19-7-9-24-11-14/h5-6,8,14,19H,7,9-11H2,1-4H3,(H,21,23)
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n/an/an/an/a 5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276027
PNG
(US10071974, Example 138 | US10071974, Example 139 ...)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C20H28N4O2/c1-13-5-4-9-24-17(13)16(14-6-7-14)22-19(24)20(2,3)23-18(25)15-11-21-8-10-26-12-15/h4-5,9,14-15,21H,6-8,10-12H2,1-3H3,(H,23,25)
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n/an/an/an/a 59.7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276030
PNG
(US10071974, Example 141 | US10071974, Example 142 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-9-21-13(12)11-19-16(21)17(2,3)20-15(22)14-6-7-18-8-10-23-14/h4-5,9,11,14,18H,6-8,10H2,1-3H3,(H,20,22)
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n/an/an/an/a 77.6n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276036
PNG
(US10071974, Example 147 | US10071974, Example 148 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C18H26N4O2/c1-12-7-5-9-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-11-19-8-6-10-24-14/h5,7,9,14,19H,6,8,10-11H2,1-4H3,(H,21,23)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275966
PNG
(US10071974, Example 77)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)[C@H]1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)/t11-/m0/s1
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n/an/an/an/a 5.10n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275972
PNG
(US10071974, Example 83)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-11-6-5-7-12-14(11)21(4)20-15(12)17(2,3)19-16(22)13-10-18-8-9-23-13/h5-7,13,18H,8-10H2,1-4H3,(H,19,22)/t13-/m0/s1
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n/an/an/an/a 4.10n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275973
PNG
(US10071974, Example 84 | US10071974, Example 85 | ...)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-7-14-15(12)22(4)21-16(14)18(2,3)20-17(23)13-10-19-8-9-24-11-13/h5-7,13,19H,8-11H2,1-4H3,(H,20,23)
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n/an/an/an/a 2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275977
PNG
(US10071974, Example 88 | US10071974, Example 89 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(F)cccc12
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n/an/an/an/a 670n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275997
PNG
(US10071974, Example 108)
Show SMILES Cc1cccn2c(cnc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-13(10-18-14(11)20)16(2,3)19-15(21)12-9-17-6-8-22-12/h4-5,7,10,12,17H,6,8-9H2,1-3H3,(H,19,21)/t12-/m0/s1
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n/an/an/an/a 58.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275998
PNG
(US10071974, Example 109)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H23N3O2/c1-12-5-4-9-20-13(12)6-7-15(20)17(2,3)19-16(21)14-11-18-8-10-22-14/h4-7,9,14,18H,8,10-11H2,1-3H3,(H,19,21)/t14-/m0/s1
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n/an/an/an/a 3.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276003
PNG
(US10071974, Example 114 | US10071974, Example 115)
Show SMILES Cc1cccn2c(ncc12)C1(CCOC1)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H22N4O3/c1-12-3-2-6-21-13(12)9-19-16(21)17(4-7-23-11-17)20-15(22)14-10-18-5-8-24-14/h2-3,6,9,14,18H,4-5,7-8,10-11H2,1H3,(H,20,22)/t14-,17?/m0/s1
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n/an/an/an/a 294n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276010
PNG
(US10071974, Example 121 | US10071974, Example 122)
Show SMILES Cc1nc(n2cccc(F)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-11-14-13(18)5-4-7-22(14)16(20-11)17(2,3)21-15(23)12-9-19-6-8-24-10-12/h4-5,7,12,19H,6,8-10H2,1-3H3,(H,21,23)
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n/an/an/an/a 11.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276012
PNG
(US10071974, Example 123 | US10071974, Example 124 ...)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O3/c1-17(2,20-15(22)12-9-18-6-8-24-11-12)16-19-10-13-14(23-3)5-4-7-21(13)16/h4-5,7,10,12,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 16.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276015
PNG
(US10071974, Example 126 | US10071974, Example 127)
Show SMILES Cc1cc(F)cn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-11-6-13(18)9-22-14(11)8-20-16(22)17(2,3)21-15(23)12-7-19-4-5-24-10-12/h6,8-9,12,19H,4-5,7,10H2,1-3H3,(H,21,23)
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n/an/an/an/a 46n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276024
PNG
(US10071974, Example 135 | US10071974, Example 136 ...)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H25N3O2/c1-13-5-4-9-21-15(13)6-7-16(21)18(2,3)20-17(22)14-11-19-8-10-23-12-14/h4-7,9,14,19H,8,10-12H2,1-3H3,(H,20,22)
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n/an/an/an/a 1.43E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276027
PNG
(US10071974, Example 138 | US10071974, Example 139 ...)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C20H28N4O2/c1-13-5-4-9-24-17(13)16(14-6-7-14)22-19(24)20(2,3)23-18(25)15-11-21-8-10-26-12-15/h4-5,9,14-15,21H,6-8,10-12H2,1-3H3,(H,23,25)
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n/an/an/an/a 22.2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275902
PNG
(US10071974, Example 13)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1nc2ccc(Cl)cc2[nH]1
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n/an/an/an/a 356n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275905
PNG
(US10071974, Example 16 | US10071974, Example 17 | ...)
Show SMILES CC(C)(COc1nccc2ccccc12)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O3/c1-19(2,22-17(23)15-11-20-9-10-24-12-15)13-25-18-16-6-4-3-5-14(16)7-8-21-18/h3-8,15,20H,9-13H2,1-2H3,(H,22,23)
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n/an/an/an/a 209n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275918
PNG
(US10071974, Example 29)
Show SMILES Cn1nc(c2c(F)cccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-16(2,19-15(22)12-9-18-7-8-23-12)14-13-10(17)5-4-6-11(13)21(3)20-14/h4-6,12,18H,7-9H2,1-3H3,(H,19,22)/t12-/m0/s1
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n/an/an/an/a 21.6n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275922
PNG
(US10071974, Example 33 | US10071974, Example 34 | ...)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-6-15-14(10-19-21(12)15)17(2,3)20-16(22)13-9-18-7-8-23-11-13/h4-6,10,13,18H,7-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 5.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275929
PNG
(US10071974, Example 40 | US10071974, Example 41 | ...)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-15-6-4-5-7-16(15)17(11-21-13)19(2,3)22-18(23)14-10-20-8-9-24-12-14/h4-7,11,14,20H,8-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 0.700n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275936
PNG
(US10071974, Example 47 | US10071974, Example 48 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-11-14-7-4-5-8-15(14)17(21-13)19(2,3)22-18(23)16-12-20-9-6-10-24-16/h4-5,7-8,11,16,20H,6,9-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 25.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275943
PNG
(US10071974, Example 54 | US10071974, Example 55 | ...)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23N3O3/c1-11-5-4-6-13-14(11)23-20-15(13)17(2,3)19-16(21)12-9-18-7-8-22-10-12/h4-6,12,18H,7-10H2,1-3H3,(H,19,21)
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n/an/an/an/a 2.90n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275943
PNG
(US10071974, Example 54 | US10071974, Example 55 | ...)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23N3O3/c1-11-5-4-6-13-14(11)23-20-15(13)17(2,3)19-16(21)12-9-18-7-8-22-10-12/h4-6,12,18H,7-10H2,1-3H3,(H,19,21)
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n/an/an/an/a 738n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275961
PNG
(US10071974, Example 72 | US10071974, Example 73 | ...)
Show SMILES [H][N](C)(C(=O)C1CNCCOC1)C(C)(C)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C17H23ClN3O3/c1-17(2,15-12-5-4-6-13(18)14(12)24-20-15)21(3)16(22)11-9-19-7-8-23-10-11/h4-6,11,19,21H,7-10H2,1-3H3
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n/an/an/an/a 8.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275969
PNG
(US10071974, Example 80 | US10071974, Example 81 | ...)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23ClN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)
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n/an/an/an/a 152n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275981
PNG
(US10071974, Example 92 | US10071974, Example 93 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(Cl)cccc12
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n/an/an/an/a 1.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276008
PNG
(US10071974, Example 119 | US10071974, Example 120)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1ncc2c(Cl)cccn12
Show InChI InChI=1S/C16H21ClN4O2/c1-16(2,20-14(22)11-8-18-5-7-23-10-11)15-19-9-13-12(17)4-3-6-21(13)15/h3-4,6,9,11,18H,5,7-8,10H2,1-2H3,(H,20,22)
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n/an/an/an/a 5.90n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276010
PNG
(US10071974, Example 121 | US10071974, Example 122)
Show SMILES Cc1nc(n2cccc(F)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-11-14-13(18)5-4-7-22(14)16(20-11)17(2,3)21-15(23)12-9-19-6-8-24-10-12/h4-5,7,12,19H,6,8-10H2,1-3H3,(H,21,23)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276020
PNG
(US10071974, Example 131 | US10071974, Example 132)
Show SMILES Cc1cccn2c(ncc12)C1(CCC1)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H24N4O2/c1-13-4-2-8-22-15(13)11-20-17(22)18(5-3-6-18)21-16(23)14-10-19-7-9-24-12-14/h2,4,8,11,14,19H,3,5-7,9-10,12H2,1H3,(H,21,23)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276024
PNG
(US10071974, Example 135 | US10071974, Example 136 ...)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H25N3O2/c1-13-5-4-9-21-15(13)6-7-16(21)18(2,3)20-17(22)14-11-19-8-10-23-12-14/h4-7,9,14,19H,8,10-12H2,1-3H3,(H,20,22)
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n/an/an/an/a 8.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276027
PNG
(US10071974, Example 138 | US10071974, Example 139 ...)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C20H28N4O2/c1-13-5-4-9-24-17(13)16(14-6-7-14)22-19(24)20(2,3)23-18(25)15-11-21-8-10-26-12-15/h4-5,9,14-15,21H,6-8,10-12H2,1-3H3,(H,23,25)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275888
PNG
(US10071974, Example 2)
Show SMILES Cc1cc2cccnc2c(n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H24N4O2/c1-12-9-13-5-4-6-20-15(13)16(21-12)18(2,3)22-17(23)14-10-19-7-8-24-11-14/h4-6,9,14,19H,7-8,10-11H2,1-3H3,(H,22,23)
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n/an/an/an/a 90.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 3.20n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275920
PNG
(US10071974, Example 31)
Show SMILES Cn1nc(c2cccc(c12)C(F)(F)F)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H21F3N4O2/c1-16(2,22-15(25)12-9-21-7-8-26-12)14-10-5-4-6-11(17(18,19)20)13(10)24(3)23-14/h4-6,12,21H,7-9H2,1-3H3,(H,22,25)/t12-/m0/s1
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n/an/an/an/a 52.7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275933
PNG
(US10071974, Example 44 | US10071974, Example 45 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-10-14-6-4-5-7-16(14)17(21-13)19(2,3)22-18(23)15-11-20-8-9-24-12-15/h4-7,10,15,20H,8-9,11-12H2,1-3H3,(H,22,23)
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n/an/an/an/a 7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275933
PNG
(US10071974, Example 44 | US10071974, Example 45 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-10-14-6-4-5-7-16(14)17(21-13)19(2,3)22-18(23)15-11-20-8-9-24-12-15/h4-7,10,15,20H,8-9,11-12H2,1-3H3,(H,22,23)
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n/an/an/an/a 795n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275951
PNG
(US10071974, Example 62 | US10071974, Example 63 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)10-8-18-6-7-22-9-10)14-11-4-3-5-12(17)13(11)23-20-14/h3-5,10,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 42n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275957
PNG
(US10071974, Example 68 | US10071974, Example 69 | ...)
Show SMILES CC(C)(NC(=O)C1CCNCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-6-7-18-8-9-22-12)14-10-4-3-5-11(17)13(10)23-20-14/h3-5,12,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 434n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275973
PNG
(US10071974, Example 84 | US10071974, Example 85 | ...)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-7-14-15(12)22(4)21-16(14)18(2,3)20-17(23)13-10-19-8-9-24-11-13/h5-7,13,19H,8-11H2,1-4H3,(H,20,23)
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n/an/an/an/a 4.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275977
PNG
(US10071974, Example 88 | US10071974, Example 89 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(F)cccc12
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n/an/an/an/a 3.10n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275980
PNG
(US10071974, Example 91)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1n[nH]c2c(Cl)cccc12
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n/an/an/an/a 3.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275986
PNG
(US10071974, Example 97)
Show SMILES Cc1cccn2c(ncc12)C1(CC1)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H20N4O2/c1-11-3-2-7-20-12(11)9-18-15(20)16(4-5-16)19-14(21)13-10-17-6-8-22-13/h2-3,7,9,13,17H,4-6,8,10H2,1H3,(H,19,21)/t13-/m0/s1
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n/an/an/an/a 40.8n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275987
PNG
(US10071974, Example 98)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1ncc2c(F)cccn12
Show InChI InChI=1S/C15H19FN4O2/c1-15(2,19-13(21)12-9-17-5-7-22-12)14-18-8-11-10(16)4-3-6-20(11)14/h3-4,6,8,12,17H,5,7,9H2,1-2H3,(H,19,21)/t12-/m0/s1
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n/an/an/an/a 85.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275989
PNG
(US10071974, Example 100)
Show SMILES Cc1cc(F)cn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-10-6-11(17)9-21-12(10)7-19-15(21)16(2,3)20-14(22)13-8-18-4-5-23-13/h6-7,9,13,18H,4-5,8H2,1-3H3,(H,20,22)/t13-/m0/s1
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n/an/an/an/a 103n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275991
PNG
(US10071974, Example 102)
Show SMILES Cc1cccn2c(ncc12)C1(CCC1)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H22N4O2/c1-12-4-2-8-21-13(12)10-19-16(21)17(5-3-6-17)20-15(22)14-11-18-7-9-23-14/h2,4,8,10,14,18H,3,5-7,9,11H2,1H3,(H,20,22)/t14-/m0/s1
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n/an/an/an/a 31n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275996
PNG
(US10071974, Example 107)
Show SMILES Cc1nc(c2cccc(C)c2n1)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C18H24N4O2/c1-11-6-5-7-13-15(11)20-12(2)21-16(13)18(3,4)22-17(23)14-10-19-8-9-24-14/h5-7,14,19H,8-10H2,1-4H3,(H,22,23)/t14-/m0/s1
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n/an/an/an/a 51.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276030
PNG
(US10071974, Example 141 | US10071974, Example 142 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-9-21-13(12)11-19-16(21)17(2,3)20-15(22)14-6-7-18-8-10-23-14/h4-5,9,11,14,18H,6-8,10H2,1-3H3,(H,20,22)
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n/an/an/an/a 90.2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276033
PNG
(US10071974, Example 144 | US10071974, Example 145 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-6-4-8-21-13(12)10-19-16(21)17(2,3)20-15(22)14-11-18-7-5-9-23-14/h4,6,8,10,14,18H,5,7,9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 29.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276036
PNG
(US10071974, Example 147 | US10071974, Example 148 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C18H26N4O2/c1-12-7-5-9-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-11-19-8-6-10-24-14/h5,7,9,14,19H,6,8,10-11H2,1-4H3,(H,21,23)
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n/an/an/an/a 185n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275897
PNG
(US10071974, Example 8)
Show SMILES CC(C)(NC(=O)[C@H]1CNCCO1)c1cccc2ncccc12
Show InChI InChI=1S/C17H21N3O2/c1-17(2,20-16(21)15-11-18-9-10-22-15)13-6-3-7-14-12(13)5-4-8-19-14/h3-8,15,18H,9-11H2,1-2H3,(H,20,21)/t15-/m1/s1
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n/an/an/an/a 258n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275905
PNG
(US10071974, Example 16 | US10071974, Example 17 | ...)
Show SMILES CC(C)(COc1nccc2ccccc12)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O3/c1-19(2,22-17(23)15-11-20-9-10-24-12-15)13-25-18-16-6-4-3-5-14(16)7-8-21-18/h3-8,15,20H,9-13H2,1-2H3,(H,22,23)
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n/an/an/an/a 3.00E+4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275908
PNG
(US10071974, Example 19)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1
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n/an/an/an/a 13.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275925
PNG
(US10071974, Example 36)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H22N4O2/c1-11-12-6-4-5-7-13(12)15(21-20-11)17(2,3)19-16(22)14-10-18-8-9-23-14/h4-7,14,18H,8-10H2,1-3H3,(H,19,22)/t14-/m0/s1
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n/an/an/an/a 25.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275926
PNG
(US10071974, Example 37)
Show SMILES Cc1nnc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H24N4O2/c1-12-14-6-4-5-7-15(14)16(22-21-12)18(2,3)20-17(23)13-10-19-8-9-24-11-13/h4-7,13,19H,8-11H2,1-3H3,(H,20,23)
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n/an/an/an/a 11.7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275933
PNG
(US10071974, Example 44 | US10071974, Example 45 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-10-14-6-4-5-7-16(14)17(21-13)19(2,3)22-18(23)15-11-20-8-9-24-12-15/h4-7,10,15,20H,8-9,11-12H2,1-3H3,(H,22,23)
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n/an/an/an/a 3.40n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275936
PNG
(US10071974, Example 47 | US10071974, Example 48 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-11-14-7-4-5-8-15(14)17(21-13)19(2,3)22-18(23)16-12-20-9-6-10-24-16/h4-5,7-8,11,16,20H,6,9-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 988n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275939
PNG
(US10071974, Example 50 | US10071974, Example 51 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-12-14-6-4-5-7-15(14)17(21-13)19(2,3)22-18(23)16-8-9-20-10-11-24-16/h4-7,12,16,20H,8-11H2,1-3H3,(H,22,23)
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n/an/an/an/a 48.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275951
PNG
(US10071974, Example 62 | US10071974, Example 63 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)10-8-18-6-7-22-9-10)14-11-4-3-5-12(17)13(11)23-20-14/h3-5,10,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 65.7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275961
PNG
(US10071974, Example 72 | US10071974, Example 73 | ...)
Show SMILES [H][N](C)(C(=O)C1CNCCOC1)C(C)(C)c1noc2c(Cl)cccc12
Show InChI InChI=1S/C17H23ClN3O3/c1-17(2,15-12-5-4-6-13(18)14(12)24-20-15)21(3)16(22)11-9-19-7-8-23-10-11/h4-6,11,19,21H,7-10H2,1-3H3
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n/an/an/an/a 1.19E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275967
PNG
(US10071974, Example 78)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)[C@@H]1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)/t11-/m1/s1
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n/an/an/an/a 430n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275999
PNG
(US10071974, Example 110 | US10071974, Example 111)
Show SMILES Cc1cccn2c(ncc12)C(C)(NC(=O)[C@@H]1CNCCO1)C1CC1
Show InChI InChI=1S/C18H24N4O2/c1-12-4-3-8-22-14(12)10-20-17(22)18(2,13-5-6-13)21-16(23)15-11-19-7-9-24-15/h3-4,8,10,13,15,19H,5-7,9,11H2,1-2H3,(H,21,23)/t15-,18?/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276001
PNG
(US10071974, Example 112 | US10071974, Example 113)
Show SMILES CC(C)CC(C)(NC(=O)[C@@H]1CNCCO1)c1ncc2c(C)cccn12
Show InChI InChI=1S/C19H28N4O2/c1-13(2)10-19(4,22-17(24)16-12-20-7-9-25-16)18-21-11-15-14(3)6-5-8-23(15)18/h5-6,8,11,13,16,20H,7,9-10,12H2,1-4H3,(H,22,24)/t16-,19?/m0/s1
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n/an/an/an/a 380n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276003
PNG
(US10071974, Example 114 | US10071974, Example 115)
Show SMILES Cc1cccn2c(ncc12)C1(CCOC1)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C17H22N4O3/c1-12-3-2-6-21-13(12)9-19-16(21)17(4-7-23-11-17)20-15(22)14-10-18-5-8-24-14/h2-3,6,9,14,18H,4-5,7-8,10-11H2,1H3,(H,20,22)/t14-,17?/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276005
PNG
(US10071974, Example 116 | US10071974, Example 117 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-7-21-14(12)10-19-16(21)17(2,3)20-15(22)13-9-18-6-8-23-11-13/h4-5,7,10,13,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 2.60n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276005
PNG
(US10071974, Example 116 | US10071974, Example 117 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-7-21-14(12)10-19-16(21)17(2,3)20-15(22)13-9-18-6-8-23-11-13/h4-5,7,10,13,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 86.8n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276017
PNG
(US10071974, Example 128 | US10071974, Example 129 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-8-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-10-19-7-9-24-11-14/h5-6,8,14,19H,7,9-11H2,1-4H3,(H,21,23)
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n/an/an/an/a 5.30n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275789
PNG
(US10071974, Example 1)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1cccc2ccccc12
Show InChI InChI=1S/C19H24N2O2/c1-19(2,21-18(22)15-12-20-10-11-23-13-15)17-9-5-7-14-6-3-4-8-16(14)17/h3-9,15,20H,10-13H2,1-2H3,(H,21,22)
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n/an/an/an/a 4.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275900
PNG
(US10071974, Example 11)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1ccnc2ccccc12
Show InChI InChI=1S/C17H21N3O2/c1-17(2,20-16(21)15-11-18-9-10-22-15)13-7-8-19-14-6-4-3-5-12(13)14/h3-8,15,18H,9-11H2,1-2H3,(H,20,21)/t15-/m0/s1
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n/an/an/an/a 26.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275905
PNG
(US10071974, Example 16 | US10071974, Example 17 | ...)
Show SMILES CC(C)(COc1nccc2ccccc12)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O3/c1-19(2,22-17(23)15-11-20-9-10-24-12-15)13-25-18-16-6-4-3-5-14(16)7-8-21-18/h3-8,15,20H,9-13H2,1-2H3,(H,22,23)
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n/an/an/an/a 393n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 192n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 36.2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275922
PNG
(US10071974, Example 33 | US10071974, Example 34 | ...)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-6-15-14(10-19-21(12)15)17(2,3)20-16(22)13-9-18-7-8-23-11-13/h4-6,10,13,18H,7-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 7.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275947
PNG
(US10071974, Example 58 | US10071974, Example 59 | ...)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)C1CNCCOC1
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n/an/an/an/a 1.30n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275950
PNG
(US10071974, Example 61)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C15H18FN3O3/c1-15(2,18-14(20)11-8-17-6-7-21-11)13-9-4-3-5-10(16)12(9)22-19-13/h3-5,11,17H,6-8H2,1-2H3,(H,18,20)/t11-/m0/s1
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n/an/an/an/a 147n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275977
PNG
(US10071974, Example 88 | US10071974, Example 89 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(F)cccc12
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n/an/an/an/a 11.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275981
PNG
(US10071974, Example 92 | US10071974, Example 93 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(Cl)cccc12
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n/an/an/an/a 2.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275981
PNG
(US10071974, Example 92 | US10071974, Example 93 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1n[nH]c2c(Cl)cccc12
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n/an/an/an/a 31n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275984
PNG
(US10071974, Example 95)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-12(11)9-18-15(20)16(2,3)19-14(21)13-10-17-6-8-22-13/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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n/an/an/an/a 4.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275988
PNG
(US10071974, Example 99)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O3/c1-16(2,19-14(21)13-10-17-6-8-23-13)15-18-9-11-12(22-3)5-4-7-20(11)15/h4-5,7,9,13,17H,6,8,10H2,1-3H3,(H,19,21)/t13-/m0/s1
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n/an/an/an/a 43.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276020
PNG
(US10071974, Example 131 | US10071974, Example 132)
Show SMILES Cc1cccn2c(ncc12)C1(CCC1)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H24N4O2/c1-13-4-2-8-22-15(13)11-20-17(22)18(5-3-6-18)21-16(23)14-10-19-7-9-24-12-14/h2,4,8,11,14,19H,3,5-7,9-10,12H2,1H3,(H,21,23)
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n/an/an/an/a 19n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276022
PNG
(US10071974, Example 133 | US10071974, Example 134)
Show SMILES Cc1nc(c2cccc(C)c2n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H26N4O2/c1-12-6-5-7-15-16(12)21-13(2)22-17(15)19(3,4)23-18(24)14-10-20-8-9-25-11-14/h5-7,14,20H,8-11H2,1-4H3,(H,23,24)
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n/an/an/an/a 98.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276024
PNG
(US10071974, Example 135 | US10071974, Example 136 ...)
Show SMILES Cc1cccn2c(ccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H25N3O2/c1-13-5-4-9-21-15(13)6-7-16(21)18(2,3)20-17(22)14-11-19-8-10-23-12-14/h4-7,9,14,19H,8,10-12H2,1-3H3,(H,20,22)
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n/an/an/an/a 3.70n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276033
PNG
(US10071974, Example 144 | US10071974, Example 145 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-6-4-8-21-13(12)10-19-16(21)17(2,3)20-15(22)14-11-18-7-5-9-23-14/h4,6,8,10,14,18H,5,7,9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 71.8n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276036
PNG
(US10071974, Example 147 | US10071974, Example 148 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C18H26N4O2/c1-12-7-5-9-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-11-19-8-6-10-24-14/h5,7,9,14,19H,6,8,10-11H2,1-4H3,(H,21,23)
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n/an/an/an/a 93n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275892
PNG
(US10071974, Example 3)
Show SMILES C[C@H](NC(=O)C1CNCCOC1)c1cccc2ccccc12
Show InChI InChI=1S/C18H22N2O2/c1-13(20-18(21)15-11-19-9-10-22-12-15)16-8-4-6-14-5-2-3-7-17(14)16/h2-8,13,15,19H,9-12H2,1H3,(H,20,21)/t13-,15?/m0/s1
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n/an/an/an/a 18n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275896
PNG
(US10071974, Example 7)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)C1CCCCC1
Show InChI InChI=1S/C14H26N2O2/c1-14(2,11-6-4-3-5-7-11)16-13(17)12-10-15-8-9-18-12/h11-12,15H,3-10H2,1-2H3,(H,16,17)/t12-/m0/s1
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n/an/an/an/a 2.42E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275915
PNG
(US10071974, Example 26 | US10071974, Example 27 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-8-9-18-10-11-23-14)15-12-6-4-5-7-13(12)21(3)20-15/h4-7,14,18H,8-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 55.8n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275919
PNG
(US10071974, Example 30)
Show SMILES Cn1nc(c2ccc(F)cc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-16(2,19-15(22)13-9-18-6-7-23-13)14-11-5-4-10(17)8-12(11)21(3)20-14/h4-5,8,13,18H,6-7,9H2,1-3H3,(H,19,22)/t13-/m0/s1
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n/an/an/an/a 13.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275932
PNG
(US10071974, Example 43)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C18H23N3O2/c1-12-10-13-6-4-5-7-14(13)16(20-12)18(2,3)21-17(22)15-11-19-8-9-23-15/h4-7,10,15,19H,8-9,11H2,1-3H3,(H,21,22)/t15-/m0/s1
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n/an/an/an/a 6.60n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275947
PNG
(US10071974, Example 58 | US10071974, Example 59 | ...)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)C1CNCCOC1
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n/an/an/an/a 4.10n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275947
PNG
(US10071974, Example 58 | US10071974, Example 59 | ...)
Show SMILES Cc1cccc2c(n[nH]c12)C(C)(C)NC(=O)C1CNCCOC1
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n/an/an/an/a 1.07E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275954
PNG
(US10071974, Example 65 | US10071974, Example 66 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-9-18-7-4-8-22-12)14-10-5-3-6-11(17)13(10)23-20-14/h3,5-6,12,18H,4,7-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 998n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275954
PNG
(US10071974, Example 65 | US10071974, Example 66 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-9-18-7-4-8-22-12)14-10-5-3-6-11(17)13(10)23-20-14/h3,5-6,12,18H,4,7-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 2.30E+4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275957
PNG
(US10071974, Example 68 | US10071974, Example 69 | ...)
Show SMILES CC(C)(NC(=O)C1CCNCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-6-7-18-8-9-22-12)14-10-4-3-5-11(17)13(10)23-20-14/h3-5,12,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 544n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275985
PNG
(US10071974, Example 96)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1ncc2c(Cl)cccn12
Show InChI InChI=1S/C15H19ClN4O2/c1-15(2,19-13(21)12-9-17-5-7-22-12)14-18-8-11-10(16)4-3-6-20(11)14/h3-4,6,8,12,17H,5,7,9H2,1-2H3,(H,19,21)/t12-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275993
PNG
(US10071974, Example 104)
Show SMILES Cc1cccn2c(nc(C3CC3)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C19H26N4O2/c1-12-5-4-9-23-16(12)15(13-6-7-13)21-18(23)19(2,3)22-17(24)14-11-20-8-10-25-14/h4-5,9,13-14,20H,6-8,10-11H2,1-3H3,(H,22,24)/t14-/m0/s1
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n/an/an/an/a 73.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276012
PNG
(US10071974, Example 123 | US10071974, Example 124 ...)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O3/c1-17(2,20-15(22)12-9-18-6-8-24-11-12)16-19-10-13-14(23-3)5-4-7-21(13)16/h4-5,7,10,12,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 32.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276012
PNG
(US10071974, Example 123 | US10071974, Example 124 ...)
Show SMILES COc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O3/c1-17(2,20-15(22)12-9-18-6-8-24-11-12)16-19-10-13-14(23-3)5-4-7-21(13)16/h4-5,7,10,12,18H,6,8-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276022
PNG
(US10071974, Example 133 | US10071974, Example 134)
Show SMILES Cc1nc(c2cccc(C)c2n1)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H26N4O2/c1-12-6-5-7-15-16(12)21-13(2)22-17(15)19(3,4)23-18(24)14-10-20-8-9-25-11-14/h5-7,14,20H,8-11H2,1-4H3,(H,23,24)
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n/an/an/an/a 55.3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276030
PNG
(US10071974, Example 141 | US10071974, Example 142 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-9-21-13(12)11-19-16(21)17(2,3)20-15(22)14-6-7-18-8-10-23-14/h4-5,9,11,14,18H,6-8,10H2,1-3H3,(H,20,22)
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n/an/an/an/a 90.5n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276033
PNG
(US10071974, Example 144 | US10071974, Example 145 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-12-6-4-8-21-13(12)10-19-16(21)17(2,3)20-15(22)14-11-18-7-5-9-23-14/h4,6,8,10,14,18H,5,7,9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275894
PNG
(US10071974, Example 5)
Show SMILES Cc1cccn2c(CNC(=O)C3CNCCOC3)ncc12
Show InChI InChI=1S/C15H20N4O2/c1-11-3-2-5-19-13(11)8-17-14(19)9-18-15(20)12-7-16-4-6-21-10-12/h2-3,5,8,12,16H,4,6-7,9-10H2,1H3,(H,18,20)
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n/an/an/an/a 20.4n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275909
PNG
(US10071974, Example 20 | US10071974, Example 21 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)12-10-18-8-9-23-11-12)15-13-6-4-5-7-14(13)21(3)20-15/h4-7,12,18H,8-11H2,1-3H3,(H,19,22)
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n/an/an/an/a 3.90n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275922
PNG
(US10071974, Example 33 | US10071974, Example 34 | ...)
Show SMILES Cc1cccc2c(cnn12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-6-15-14(10-19-21(12)15)17(2,3)20-16(22)13-9-18-7-8-23-11-13/h4-6,10,13,18H,7-9,11H2,1-3H3,(H,20,22)
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n/an/an/an/a 2.87E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275927
PNG
(US10071974, Example 38)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCO1
Show InChI InChI=1S/C18H23N3O2/c1-12-13-6-4-5-7-14(13)15(10-20-12)18(2,3)21-17(22)16-11-19-8-9-23-16/h4-7,10,16,19H,8-9,11H2,1-3H3,(H,21,22)
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n/an/an/an/a 1.30n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275936
PNG
(US10071974, Example 47 | US10071974, Example 48 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-11-14-7-4-5-8-15(14)17(21-13)19(2,3)22-18(23)16-12-20-9-6-10-24-16/h4-5,7-8,11,16,20H,6,9-10,12H2,1-3H3,(H,22,23)
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n/an/an/an/a 18.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275951
PNG
(US10071974, Example 62 | US10071974, Example 63 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)10-8-18-6-7-22-9-10)14-11-4-3-5-12(17)13(11)23-20-14/h3-5,10,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 1.86E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275954
PNG
(US10071974, Example 65 | US10071974, Example 66 | ...)
Show SMILES CC(C)(NC(=O)C1CNCCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-9-18-7-4-8-22-12)14-10-5-3-6-11(17)13(10)23-20-14/h3,5-6,12,18H,4,7-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 624n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275957
PNG
(US10071974, Example 68 | US10071974, Example 69 | ...)
Show SMILES CC(C)(NC(=O)C1CCNCCO1)c1noc2c(F)cccc12
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,19-15(21)12-6-7-18-8-9-22-12)14-10-4-3-5-11(17)13(10)23-20-14/h3-5,12,18H,6-9H2,1-2H3,(H,19,21)
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n/an/an/an/a 628n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275969
PNG
(US10071974, Example 80 | US10071974, Example 81 | ...)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23ClN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)
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n/an/an/an/a 4.80n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275969
PNG
(US10071974, Example 80 | US10071974, Example 81 | ...)
Show SMILES Cn1nc(c2cccc(Cl)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23ClN4O2/c1-17(2,20-16(23)11-9-19-7-8-24-10-11)15-12-5-4-6-13(18)14(12)22(3)21-15/h4-6,11,19H,7-10H2,1-3H3,(H,20,23)
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n/an/an/an/a 3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275973
PNG
(US10071974, Example 84 | US10071974, Example 85 | ...)
Show SMILES Cc1cccc2c(nn(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-7-14-15(12)22(4)21-16(14)18(2,3)20-17(23)13-10-19-8-9-24-11-13/h5-7,13,19H,8-11H2,1-4H3,(H,20,23)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275990
PNG
(US10071974, Example 101 | US10071974, Example 103)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1nc(C2CC2)c2c(F)cccn12
Show InChI InChI=1S/C18H23FN4O2/c1-18(2,22-16(24)13-10-20-7-9-25-13)17-21-14(11-5-6-11)15-12(19)4-3-8-23(15)17/h3-4,8,11,13,20H,5-7,9-10H2,1-2H3,(H,22,24)/t13-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275990
PNG
(US10071974, Example 101 | US10071974, Example 103)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1nc(C2CC2)c2c(F)cccn12
Show InChI InChI=1S/C18H23FN4O2/c1-18(2,22-16(24)13-10-20-7-9-25-13)17-21-14(11-5-6-11)15-12(19)4-3-8-23(15)17/h3-4,8,11,13,20H,5-7,9-10H2,1-2H3,(H,22,24)/t13-/m0/s1
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n/an/an/an/a 60.7n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275994
PNG
(US10071974, Example 105)
Show SMILES Cc1cccn2c(nnc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C15H21N5O2/c1-10-5-4-7-20-12(10)18-19-14(20)15(2,3)17-13(21)11-9-16-6-8-22-11/h4-5,7,11,16H,6,8-9H2,1-3H3,(H,17,21)/t11-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276005
PNG
(US10071974, Example 116 | US10071974, Example 117 ...)
Show SMILES Cc1cccn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H24N4O2/c1-12-5-4-7-21-14(12)10-19-16(21)17(2,3)20-15(22)13-9-18-6-8-23-11-13/h4-5,7,10,13,18H,6,8-9,11H2,1-3H3,(H,20,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276008
PNG
(US10071974, Example 119 | US10071974, Example 120)
Show SMILES CC(C)(NC(=O)C1CNCCOC1)c1ncc2c(Cl)cccn12
Show InChI InChI=1S/C16H21ClN4O2/c1-16(2,20-14(22)11-8-18-5-7-23-10-11)15-19-9-13-12(17)4-3-6-21(13)15/h3-4,6,9,11,18H,5,7-8,10H2,1-2H3,(H,20,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276015
PNG
(US10071974, Example 126 | US10071974, Example 127)
Show SMILES Cc1cc(F)cn2c(ncc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23FN4O2/c1-11-6-13(18)9-22-14(11)8-20-16(22)17(2,3)21-15(23)12-7-19-4-5-24-10-12/h6,8-9,12,19H,4-5,7,10H2,1-3H3,(H,21,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM276017
PNG
(US10071974, Example 128 | US10071974, Example 129 ...)
Show SMILES Cc1nc(n2cccc(C)c12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C18H26N4O2/c1-12-6-5-8-22-15(12)13(2)20-17(22)18(3,4)21-16(23)14-10-19-7-9-24-11-14/h5-6,8,14,19H,7,9-11H2,1-4H3,(H,21,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275895
PNG
(US10071974, Example 12 | US10071974, Example 6)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1cccc2ccccc12
Show InChI InChI=1S/C18H22N2O2/c1-18(2,20-17(21)16-12-19-10-11-22-16)15-9-5-7-13-6-3-4-8-14(13)15/h3-9,16,19H,10-12H2,1-2H3,(H,20,21)/t16-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275898
PNG
(US10071974, Example 9)
Show SMILES CC(C)(COc1cnccc1C(F)(F)F)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C15H20F3N3O3/c1-14(2,21-13(22)12-8-20-5-6-23-12)9-24-11-7-19-4-3-10(11)15(16,17)18/h3-4,7,12,20H,5-6,8-9H2,1-2H3,(H,21,22)/t12-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275899
PNG
(US10071974, Example 10)
Show SMILES C[C@H](NC(=O)[C@@H]1CNCCO1)c1cccc2ccccc12
Show InChI InChI=1S/C17H20N2O2/c1-12(19-17(20)16-11-18-9-10-21-16)14-8-4-6-13-5-2-3-7-15(13)14/h2-8,12,16,18H,9-11H2,1H3,(H,19,20)/t12-,16-/m0/s1
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n/an/an/an/a 51.2n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275895
PNG
(US10071974, Example 12 | US10071974, Example 6)
Show SMILES CC(C)(NC(=O)[C@@H]1CNCCO1)c1cccc2ccccc12
Show InChI InChI=1S/C18H22N2O2/c1-18(2,20-17(21)16-12-19-10-11-22-16)15-9-5-7-13-6-3-4-8-14(13)15/h3-9,16,19H,10-12H2,1-2H3,(H,20,21)/t16-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275904
PNG
(US10071974, Example 15)
Show SMILES Cc1ccccc1OCC(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H24N2O3/c1-12-6-4-5-7-13(12)21-11-16(2,3)18-15(19)14-10-17-8-9-20-14/h4-7,14,17H,8-11H2,1-3H3,(H,18,19)/t14-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275912
PNG
(US10071974, Example 23 | US10071974, Example 24 | ...)
Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
Show InChI InChI=1S/C17H24N4O2/c1-17(2,19-16(22)14-11-18-9-6-10-23-14)15-12-7-4-5-8-13(12)21(3)20-15/h4-5,7-8,14,18H,6,9-11H2,1-3H3,(H,19,22)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275929
PNG
(US10071974, Example 40 | US10071974, Example 41 | ...)
Show SMILES Cc1ncc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C19H25N3O2/c1-13-15-6-4-5-7-16(15)17(11-21-13)19(2,3)22-18(23)14-10-20-8-9-24-12-14/h4-7,11,14,20H,8-10,12H2,1-3H3,(H,22,23)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275939
PNG
(US10071974, Example 50 | US10071974, Example 51 | ...)
Show SMILES Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)C1CCNCCO1
Show InChI InChI=1S/C19H25N3O2/c1-13-12-14-6-4-5-7-15(14)17(21-13)19(2,3)22-18(23)16-8-9-20-10-11-24-16/h4-7,12,16,20H,8-11H2,1-3H3,(H,22,23)
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n/an/an/an/a 42.9n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275943
PNG
(US10071974, Example 54 | US10071974, Example 55 | ...)
Show SMILES Cc1cccc2c(noc12)C(C)(C)NC(=O)C1CNCCOC1
Show InChI InChI=1S/C17H23N3O3/c1-11-5-4-6-13-14(11)23-20-15(13)17(2,3)19-16(21)12-9-18-7-8-22-10-12/h4-6,12,18H,7-10H2,1-3H3,(H,19,21)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275964
PNG
(US10071974, Example 75)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H21FN4O2/c1-16(2,19-15(22)12-9-18-7-8-23-12)14-10-5-4-6-11(17)13(10)21(3)20-14/h4-6,12,18H,7-9H2,1-3H3,(H,19,22)/t12-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275965
PNG
(US10071974, Example 76)
Show SMILES Cn1nc(c2cccc(F)c12)C(C)(C)NC(=O)C1CCCCNC1
Show InChI InChI=1S/C18H25FN4O/c1-18(2,21-17(24)12-7-4-5-10-20-11-12)16-13-8-6-9-14(19)15(13)23(3)22-16/h6,8-9,12,20H,4-5,7,10-11H2,1-3H3,(H,21,24)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%