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Patent code US10077247

Compile Data Set for Download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285498
PNG
(4-[4-Cyano-2-({[(1R,2R)-6′-(methylcarbamoyl)...)
Show SMILES CNC(=O)c1ccc2CC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C25H25N3O4/c1-27-23(31)18-8-7-16-9-10-25(19(16)12-18)13-20(25)24(32)28-21-11-15(14-26)5-6-17(21)3-2-4-22(29)30/h5-8,11-12,20H,2-4,9-10,13H2,1H3,(H,27,31)(H,28,32)(H,29,30)/t20-,25-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285464
PNG
(4-{4-Cyano-2-[({2′R, 4S)-6-[(1-methyl 1H-pyr...)
Show SMILES Cn1cc(NC(=O)c2ccc3OCC[C@]4(C[C@H]4C(=O)Nc4cc(ccc4CCCC(O)=O)C#N)c3c2)cn1
Show InChI InChI=1S/C28H27N5O5/c1-33-16-20(15-30-33)31-26(36)19-7-8-24-21(12-19)28(9-10-38-24)13-22(28)27(37)32-23-11-17(14-29)5-6-18(23)3-2-4-25(34)35/h5-8,11-12,15-16,22H,2-4,9-10,13H2,1H3,(H,31,36)(H,32,37)(H,34,35)/t22-,28-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285502
PNG
(US10077247, Example 20-2)
Show SMILES COCCNC(=O)c1cc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)cc1F
Show InChI InChI=1S/C27H28FN3O6/c1-36-10-8-30-25(34)18-12-19-23(13-21(18)28)37-9-7-27(19)14-20(27)26(35)31-22-11-16(15-29)5-6-17(22)3-2-4-24(32)33/h5-6,11-13,20H,2-4,7-10,14H2,1H3,(H,30,34)(H,31,35)(H,32,33)/t20-,27-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285487
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(1H-pyrazol-1-yl)...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-n1cccn1)C#N
Show InChI InChI=1S/C26H24N4O4/c27-16-17-5-6-18(3-1-4-24(31)32)22(13-17)29-25(33)21-15-26(21)9-12-34-23-8-7-19(14-20(23)26)30-11-2-10-28-30/h2,5-8,10-11,13-14,21H,1,3-4,9,12,15H2,(H,29,33)(H,31,32)/t21-,26-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285480
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(propylcarbamoyl)...)
Show SMILES CCCNC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C27H29N3O5/c1-2-11-29-25(33)19-8-9-23-20(14-19)27(10-12-35-23)15-21(27)26(34)30-22-13-17(16-28)6-7-18(22)4-3-5-24(31)32/h6-9,13-14,21H,2-5,10-12,15H2,1H3,(H,29,33)(H,30,34)(H,31,32)/t21-,27-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285470
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(3-pyridazinylcar...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)Nc1cccnn1)C#N
Show InChI InChI=1S/C28H25N5O5/c29-16-17-6-7-18(3-1-5-25(34)35)22(13-17)31-27(37)21-15-28(21)10-12-38-23-9-8-19(14-20(23)28)26(36)32-24-4-2-11-30-33-24/h2,4,6-9,11,13-14,21H,1,3,5,10,12,15H2,(H,31,37)(H,34,35)(H,32,33,36)/t21-,28-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285036
PNG
(US10077247, Example 1)
Show SMILES CNC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C25H25N3O5/c1-27-23(31)17-7-8-21-18(12-17)25(9-10-33-21)13-19(25)24(32)28-20-11-15(14-26)5-6-16(20)3-2-4-22(29)30/h5-8,11-12,19H,2-4,9-10,13H2,1H3,(H,27,31)(H,28,32)(H,29,30)/t19-,25-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285500
PNG
(4-{4-Cyano-2-[({(1R,2R)-6′-[(1-methyl-1H-pyr...)
Show SMILES Cn1cc(NC(=O)c2ccc3CC[C@]4(C[C@H]4C(=O)Nc4cc(ccc4CCCC(O)=O)C#N)c3c2)cn1
Show InChI InChI=1S/C28H27N5O4/c1-33-16-21(15-30-33)31-26(36)20-8-7-18-9-10-28(22(18)12-20)13-23(28)27(37)32-24-11-17(14-29)5-6-19(24)3-2-4-25(34)35/h5-8,11-12,15-16,23H,2-4,9-10,13H2,1H3,(H,31,36)(H,32,37)(H,34,35)/t23-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285483
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(5-methyl-1,3,4-o...)
Show SMILES Cc1nnc(o1)-c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C26H24N4O5/c1-15-29-30-25(35-15)18-7-8-22-19(12-18)26(9-10-34-22)13-20(26)24(33)28-21-11-16(14-27)5-6-17(21)3-2-4-23(31)32/h5-8,11-12,20H,2-4,9-10,13H2,1H3,(H,28,33)(H,31,32)/t20-,26-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285484
PNG
(US10077247, Example 5)
Show SMILES Cc1noc(n1)-c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C26H24N4O5/c1-15-28-25(35-30-15)18-7-8-22-19(12-18)26(9-10-34-22)13-20(26)24(33)29-21-11-16(14-27)5-6-17(21)3-2-4-23(31)32/h5-8,11-12,20H,2-4,9-10,13H2,1H3,(H,29,33)(H,31,32)/t20-,26-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285499
PNG
(4-{4-Cyano-2-[({(1R,2R)-6′-[(2-methoxyethyl)...)
Show SMILES COCCNC(=O)c1ccc2CC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C27H29N3O5/c1-35-12-11-29-25(33)20-8-7-18-9-10-27(21(18)14-20)15-22(27)26(34)30-23-13-17(16-28)5-6-19(23)3-2-4-24(31)32/h5-8,13-14,22H,2-4,9-12,15H2,1H3,(H,29,33)(H,30,34)(H,31,32)/t22-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285482
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(ethylcarbamoyl)-...)
Show SMILES CCNC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C26H27N3O5/c1-2-28-24(32)18-8-9-22-19(13-18)26(10-11-34-22)14-20(26)25(33)29-21-12-16(15-27)6-7-17(21)4-3-5-23(30)31/h6-9,12-13,20H,2-5,10-11,14H2,1H3,(H,28,32)(H,29,33)(H,30,31)/t20-,26-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285463
PNG
(US10077247, Example 2-4)
Show SMILES COC[C@H](C)NC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C28H31N3O6/c1-17(16-36-2)30-26(34)20-8-9-24-21(13-20)28(10-11-37-24)14-22(28)27(35)31-23-12-18(15-29)6-7-19(23)4-3-5-25(32)33/h6-9,12-13,17,22H,3-5,10-11,14,16H2,1-2H3,(H,30,34)(H,31,35)(H,32,33)/t17-,22-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285476
PNG
(US10077247, Example 2-39)
Show SMILES CC(C)(C)n1cc(NC(=O)c2ccc3OCC[C@]4(C[C@H]4C(=O)Nc4cc(ccc4CCCC(O)=O)C#N)c3c2)cn1
Show InChI InChI=1S/C31H33N5O5/c1-30(2,3)36-18-22(17-33-36)34-28(39)21-9-10-26-23(14-21)31(11-12-41-26)15-24(31)29(40)35-25-13-19(16-32)7-8-20(25)5-4-6-27(37)38/h7-10,13-14,17-18,24H,4-6,11-12,15H2,1-3H3,(H,34,39)(H,35,40)(H,37,38)/t24-,31-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285478
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(1,2-oxazol-5-ylc...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)Nc1ccno1)C#N
Show InChI InChI=1S/C27H24N4O6/c28-15-16-4-5-17(2-1-3-24(32)33)21(12-16)30-26(35)20-14-27(20)9-11-36-22-7-6-18(13-19(22)27)25(34)31-23-8-10-29-37-23/h4-8,10,12-13,20H,1-3,9,11,14H2,(H,30,35)(H,31,34)(H,32,33)/t20-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285474
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(1,2-oxazol-3-ylc...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)Nc1ccon1)C#N
Show InChI InChI=1S/C27H24N4O6/c28-15-16-4-5-17(2-1-3-24(32)33)21(12-16)29-26(35)20-14-27(20)9-11-36-22-7-6-18(13-19(22)27)25(34)30-23-8-10-37-31-23/h4-8,10,12-13,20H,1-3,9,11,14H2,(H,29,35)(H,32,33)(H,30,31,34)/t20-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285462
PNG
(US10077247, Example 2-3)
Show SMILES CC(C)(C)NC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C28H31N3O5/c1-27(2,3)31-25(34)19-9-10-23-20(14-19)28(11-12-36-23)15-21(28)26(35)30-22-13-17(16-29)7-8-18(22)5-4-6-24(32)33/h7-10,13-14,21H,4-6,11-12,15H2,1-3H3,(H,30,35)(H,31,34)(H,32,33)/t21-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285489
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(6-methoxy-3-pyri...)
Show SMILES COc1ccc(cn1)-c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C29H27N3O5/c1-36-26-10-8-21(17-31-26)20-7-9-25-22(14-20)29(11-12-37-25)15-23(29)28(35)32-24-13-18(16-30)5-6-19(24)3-2-4-27(33)34/h5-10,13-14,17,23H,2-4,11-12,15H2,1H3,(H,32,35)(H,33,34)/t23-,29-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285495
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(1-methyl-1H-1,2,...)
Show SMILES Cn1cc(nn1)-c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C26H25N5O4/c1-31-15-22(29-30-31)18-7-8-23-19(12-18)26(9-10-35-23)13-20(26)25(34)28-21-11-16(14-27)5-6-17(21)3-2-4-24(32)33/h5-8,11-12,15,20H,2-4,9-10,13H2,1H3,(H,28,34)(H,32,33)/t20-,26-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285479
PNG
(4-{4-Cyano-2-[({(2′R,4S)-6-[(1-methyl-1H-pyr...)
Show SMILES Cn1nccc1NC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C28H27N5O5/c1-33-24(9-11-30-33)32-26(36)19-7-8-23-20(14-19)28(10-12-38-23)15-21(28)27(37)31-22-13-17(16-29)5-6-18(22)3-2-4-25(34)35/h5-9,11,13-14,21H,2-4,10,12,15H2,1H3,(H,31,37)(H,32,36)(H,34,35)/t21-,28-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285471
PNG
(4-{4-Cyano-2-[({(2′R,4S)-6-[(2,2-difluoroeth...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)NCC(F)F)C#N
Show InChI InChI=1S/C26H25F2N3O5/c27-22(28)14-30-24(34)17-6-7-21-18(11-17)26(8-9-36-21)12-19(26)25(35)31-20-10-15(13-29)4-5-16(20)2-1-3-23(32)33/h4-7,10-11,19,22H,1-3,8-9,12,14H2,(H,30,34)(H,31,35)(H,32,33)/t19-,26-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285486
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(3-pyridinyl)-2,3...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-c1cccnc1)C#N
Show InChI InChI=1S/C28H25N3O4/c29-16-18-6-7-19(3-1-5-26(32)33)24(13-18)31-27(34)23-15-28(23)10-12-35-25-9-8-20(14-22(25)28)21-4-2-11-30-17-21/h2,4,6-9,11,13-14,17,23H,1,3,5,10,12,15H2,(H,31,34)(H,32,33)/t23-,28-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285466
PNG
(4-[4-cyano-2-({[(2′R,4S)-6-(cyclopropylcarba...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)NC1CC1)C#N
Show InChI InChI=1S/C27H27N3O5/c28-15-16-4-5-17(2-1-3-24(31)32)22(12-16)30-26(34)21-14-27(21)10-11-35-23-9-6-18(13-20(23)27)25(33)29-19-7-8-19/h4-6,9,12-13,19,21H,1-3,7-8,10-11,14H2,(H,29,33)(H,30,34)(H,31,32)/t21-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285496
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(3-pyridazinyl)-2...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-c1cccnn1)C#N
Show InChI InChI=1S/C27H24N4O4/c28-16-17-6-7-18(3-1-5-25(32)33)23(13-17)30-26(34)21-15-27(21)10-12-35-24-9-8-19(14-20(24)27)22-4-2-11-29-31-22/h2,4,6-9,11,13-14,21H,1,3,5,10,12,15H2,(H,30,34)(H,32,33)/t21-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285512
PNG
(4-[4-Cyano-2-({[(1S,2R)-3′,3′-dimethyl...)
Show SMILES CNC(=O)c1ccc2c(c1)[C@@]1(C[C@H]1C(=O)Nc1cc(ccc1CCCC(O)=O)C#N)CC2(C)C
Show InChI InChI=1S/C27H29N3O4/c1-26(2)15-27(20-12-18(24(33)29-3)9-10-19(20)26)13-21(27)25(34)30-22-11-16(14-28)7-8-17(22)5-4-6-23(31)32/h7-12,21H,4-6,13,15H2,1-3H3,(H,29,33)(H,30,34)(H,31,32)/t21-,27+/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285465
PNG
(4-{4-Cyano-2-[({(2′R,4S)-6-[(1-methyl-1H-pyr...)
Show SMILES Cn1ccc(NC(=O)c2ccc3OCC[C@]4(C[C@H]4C(=O)Nc4cc(ccc4CCCC(O)=O)C#N)c3c2)n1
Show InChI InChI=1S/C28H27N5O5/c1-33-11-9-24(32-33)31-26(36)19-7-8-23-20(14-19)28(10-12-38-23)15-21(28)27(37)30-22-13-17(16-29)5-6-18(22)3-2-4-25(34)35/h5-9,11,13-14,21H,2-4,10,12,15H2,1H3,(H,30,37)(H,34,35)(H,31,32,36)/t21-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285468
PNG
(4-[4 Cyano 2-({[(2′R,4S)-6-(cyclopentylcarba...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)NC1CCCC1)C#N
Show InChI InChI=1S/C29H31N3O5/c30-17-18-8-9-19(4-3-7-26(33)34)24(14-18)32-28(36)23-16-29(23)12-13-37-25-11-10-20(15-22(25)29)27(35)31-21-5-1-2-6-21/h8-11,14-15,21,23H,1-7,12-13,16H2,(H,31,35)(H,32,36)(H,33,34)/t23-,29-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285492
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(1H-pyrrolo[2,3-b...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-c1cnc2[nH]ccc2c1)C#N
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285508
PNG
(4-[4-Cyano-2-({[(2′R,3S)-5-(3-pyridinyl)spir...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11COc2ccc(cc12)-c1cccnc1)C#N
Show InChI InChI=1S/C27H23N3O4/c28-14-17-6-7-18(3-1-5-25(31)32)23(11-17)30-26(33)22-13-27(22)16-34-24-9-8-19(12-21(24)27)20-4-2-10-29-15-20/h2,4,6-12,15,22H,1,3,5,13,16H2,(H,30,33)(H,31,32)/t22-,27+/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285469
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(2-pyridinylcarba...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)Nc1ccccn1)C#N
Show InChI InChI=1S/C29H26N4O5/c30-17-18-7-8-19(4-3-6-26(34)35)23(14-18)32-28(37)22-16-29(22)11-13-38-24-10-9-20(15-21(24)29)27(36)33-25-5-1-2-12-31-25/h1-2,5,7-10,12,14-15,22H,3-4,6,11,13,16H2,(H,32,37)(H,34,35)(H,31,33,36)/t22-,29-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285475
PNG
(US10077247, Example 2-38)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)NC1CCC1)[N+]#[C-]
Show InChI InChI=1S/C28H29N3O5/c1-29-20-10-8-17(4-2-7-25(32)33)23(15-20)31-27(35)22-16-28(22)12-13-36-24-11-9-18(14-21(24)28)26(34)30-19-5-3-6-19/h8-11,14-15,19,22H,2-7,12-13,16H2,(H,30,34)(H,31,35)(H,32,33)/t22-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285461
PNG
(US10077247, Example 2-2)
Show SMILES COCCNC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C27H29N3O6/c1-35-12-10-29-25(33)19-7-8-23-20(14-19)27(9-11-36-23)15-21(27)26(34)30-22-13-17(16-28)5-6-18(22)3-2-4-24(31)32/h5-8,13-14,21H,2-4,9-12,15H2,1H3,(H,29,33)(H,30,34)(H,31,32)/t21-,27-/m0/s1
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285511
PNG
(4-[4-Cyano-2-({[(1S,2R)-6′-[(2-methoxyethyl)...)
Show SMILES COCCNC(=O)c1ccc2c(c1)[C@@]1(C[C@H]1C(=O)Nc1cc(ccc1CCCC(O)=O)C#N)CC2(C)C
Show InChI InChI=1S/C29H33N3O5/c1-28(2)17-29(22-14-20(9-10-21(22)28)26(35)31-11-12-37-3)15-23(29)27(36)32-24-13-18(16-30)7-8-19(24)5-4-6-25(33)34/h7-10,13-14,23H,4-6,11-12,15,17H2,1-3H3,(H,31,35)(H,32,36)(H,33,34)/t23-,29+/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285473
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(2-pyrimidinylcar...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)Nc1ncccn1)C#N
Show InChI InChI=1S/C28H25N5O5/c29-16-17-5-6-18(3-1-4-24(34)35)22(13-17)32-26(37)21-15-28(21)9-12-38-23-8-7-19(14-20(23)28)25(36)33-27-30-10-2-11-31-27/h2,5-8,10-11,13-14,21H,1,3-4,9,12,15H2,(H,32,37)(H,34,35)(H,30,31,33,36)/t21-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285494
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(1,3-oxazol-2-yl)...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-c1ncco1)C#N
Show InChI InChI=1S/C26H23N3O5/c27-15-16-4-5-17(2-1-3-23(30)31)21(12-16)29-24(32)20-14-26(20)8-10-33-22-7-6-18(13-19(22)26)25-28-9-11-34-25/h4-7,9,11-13,20H,1-3,8,10,14H2,(H,29,32)(H,30,31)/t20-,26-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285490
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(6-methyl-3-pyrid...)
Show SMILES Cc1ccc(cn1)-c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C29H27N3O4/c1-18-5-7-22(17-31-18)21-9-10-26-23(14-21)29(11-12-36-26)15-24(29)28(35)32-25-13-19(16-30)6-8-20(25)3-2-4-27(33)34/h5-10,13-14,17,24H,2-4,11-12,15H2,1H3,(H,32,35)(H,33,34)/t24-,29-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285513
PNG
(4-[4-Cyano-2-({[(1S,2R)-3′,3′-dimethyl...)
Show SMILES CC1(C)C[C@]2(C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)c2cc(ccc12)-c1cccnc1
Show InChI InChI=1S/C30H29N3O3/c1-29(2)18-30(24-14-21(10-11-23(24)29)22-6-4-12-32-17-22)15-25(30)28(36)33-26-13-19(16-31)8-9-20(26)5-3-7-27(34)35/h4,6,8-14,17,25H,3,5,7,15,18H2,1-2H3,(H,33,36)(H,34,35)/t25-,30+/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285491
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(6-fluoro-3-pyrid...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-c1ccc(F)nc1)C#N
Show InChI InChI=1S/C28H24FN3O4/c29-25-9-7-20(16-31-25)19-6-8-24-21(13-19)28(10-11-36-24)14-22(28)27(35)32-23-12-17(15-30)4-5-18(23)2-1-3-26(33)34/h4-9,12-13,16,22H,1-3,10-11,14H2,(H,32,35)(H,33,34)/t22-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285510
PNG
(4-{4-Cyano-2-[({(2′R,3S)-5-[(2-methoxyethyl)...)
Show SMILES COCCNC(=O)c1ccc2OC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C26H27N3O6/c1-34-10-9-28-24(32)18-7-8-22-19(12-18)26(15-35-22)13-20(26)25(33)29-21-11-16(14-27)5-6-17(21)3-2-4-23(30)31/h5-8,11-12,20H,2-4,9-10,13,15H2,1H3,(H,28,32)(H,29,33)(H,30,31)/t20-,26+/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285504
PNG
(4-[4-Cyano-2-({[(2′R,4S)-7-(methylcarbamoyl)...)
Show SMILES CNC(=O)c1ccc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)c1
Show InChI InChI=1S/C25H25N3O5/c1-27-23(31)17-7-8-18-21(12-17)33-10-9-25(18)13-19(25)24(32)28-20-11-15(14-26)5-6-16(20)3-2-4-22(29)30/h5-8,11-12,19H,2-4,9-10,13H2,1H3,(H,27,31)(H,28,32)(H,29,30)/t19-,25-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285497
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(5-fluoro-2-pyrid...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-c1ccc(F)cn1)C#N
Show InChI InChI=1S/C28H24FN3O4/c29-20-7-8-23(31-16-20)19-6-9-25-21(13-19)28(10-11-36-25)14-22(28)27(35)32-24-12-17(15-30)4-5-18(24)2-1-3-26(33)34/h4-9,12-13,16,22H,1-3,10-11,14H2,(H,32,35)(H,33,34)/t22-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285505
PNG
(4-{4-Cyano-2-[({(2′R,4S)-7-[(2-methoxyethyl)...)
Show SMILES COCCNC(=O)c1ccc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)c1
Show InChI InChI=1S/C27H29N3O6/c1-35-12-10-29-25(33)19-7-8-20-23(14-19)36-11-9-27(20)15-21(27)26(34)30-22-13-17(16-28)5-6-18(22)3-2-4-24(31)32/h5-8,13-14,21H,2-4,9-12,15H2,1H3,(H,29,33)(H,30,34)(H,31,32)/t21-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285477
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(tetrahydro-2H-py...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)NC1CCOCC1)C#N
Show InChI InChI=1S/C29H31N3O6/c30-17-18-4-5-19(2-1-3-26(33)34)24(14-18)32-28(36)23-16-29(23)10-13-38-25-7-6-20(15-22(25)29)27(35)31-21-8-11-37-12-9-21/h4-7,14-15,21,23H,1-3,8-13,16H2,(H,31,35)(H,32,36)(H,33,34)/t23-,29-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285509
PNG
(4-[4-Cyano-2-({[(2′R,3S)-5-(methylcarbamoyl)...)
Show SMILES CNC(=O)c1ccc2OC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C24H23N3O5/c1-26-22(30)16-7-8-20-17(10-16)24(13-32-20)11-18(24)23(31)27-19-9-14(12-25)5-6-15(19)3-2-4-21(28)29/h5-10,18H,2-4,11,13H2,1H3,(H,26,30)(H,27,31)(H,28,29)/t18-,24+/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285467
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(isopropylcarbamo...)
Show SMILES CC(C)NC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C27H29N3O5/c1-16(2)29-25(33)19-8-9-23-20(13-19)27(10-11-35-23)14-21(27)26(34)30-22-12-17(15-28)6-7-18(22)4-3-5-24(31)32/h6-9,12-13,16,21H,3-5,10-11,14H2,1-2H3,(H,29,33)(H,30,34)(H,31,32)/t21-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285481
PNG
(4-{4-Cyano-2-[({(2′R,4S)-6-[(2-ethoxyethyl)c...)
Show SMILES CCOCCNC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C28H31N3O6/c1-2-36-13-11-30-26(34)20-8-9-24-21(15-20)28(10-12-37-24)16-22(28)27(35)31-23-14-18(17-29)6-7-19(23)4-3-5-25(32)33/h6-9,14-15,22H,2-5,10-13,16H2,1H3,(H,30,34)(H,31,35)(H,32,33)/t22-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285507
PNG
(4-{4-Cyano-2-[({(2′R,4S)-7-methoxy-6-[(2-met...)
Show SMILES COCCNC(=O)c1cc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)cc1OC
Show InChI InChI=1S/C28H31N3O7/c1-36-11-9-30-26(34)19-13-20-24(14-23(19)37-2)38-10-8-28(20)15-21(28)27(35)31-22-12-17(16-29)6-7-18(22)4-3-5-25(32)33/h6-7,12-14,21H,3-5,8-11,15H2,1-2H3,(H,30,34)(H,31,35)(H,32,33)/t21-,28-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285501
PNG
(4-[4-Cyano-2-(({[(2′R,4S)-7-fluoro-6-(methyl...)
Show SMILES CNC(=O)c1cc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)cc1F
Show InChI InChI=1S/C25H24FN3O5/c1-28-23(32)16-10-17-21(11-19(16)26)34-8-7-25(17)12-18(25)24(33)29-20-9-14(13-27)5-6-15(20)3-2-4-22(30)31/h5-6,9-11,18H,2-4,7-8,12H2,1H3,(H,28,32)(H,29,33)(H,30,31)/t18-,25-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285488
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-(2-oxo-1-pyrrolid...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)N1CCCC1=O)C#N
Show InChI InChI=1S/C27H27N3O5/c28-16-17-6-7-18(3-1-5-25(32)33)22(13-17)29-26(34)21-15-27(21)10-12-35-23-9-8-19(14-20(23)27)30-11-2-4-24(30)31/h6-9,13-14,21H,1-5,10-12,15H2,(H,29,34)(H,32,33)/t21-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285503
PNG
(4-[4-Cyano-2-({[(2′R,4S)-7-fluoro-6-(isoprop...)
Show SMILES CC(C)NC(=O)c1cc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)cc1F
Show InChI InChI=1S/C27H28FN3O5/c1-15(2)30-25(34)18-11-19-23(12-21(18)28)36-9-8-27(19)13-20(27)26(35)31-22-10-16(14-29)6-7-17(22)4-3-5-24(32)33/h6-7,10-12,15,20H,3-5,8-9,13H2,1-2H3,(H,30,34)(H,31,35)(H,32,33)/t20-,27-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285472
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-{[(3S)-1-methyl-3...)
Show SMILES CN1CCC(C1)NC(=O)c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C29H32N4O5/c1-33-11-9-21(17-33)31-27(36)20-7-8-25-22(14-20)29(10-12-38-25)15-23(29)28(37)32-24-13-18(16-30)5-6-19(24)3-2-4-26(34)35/h5-8,13-14,21,23H,2-4,9-12,15,17H2,1H3,(H,31,36)(H,32,37)(H,34,35)/t21?,23-,29-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285493
PNG
(4-{4-Cyano-2-[({(2′R,4S)-6-[6-(methylamino)-...)
Show SMILES CNc1ccc(cn1)-c1ccc2OCC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C29H28N4O4/c1-31-26-10-8-21(17-32-26)20-7-9-25-22(14-20)29(11-12-37-25)15-23(29)28(36)33-24-13-18(16-30)5-6-19(24)3-2-4-27(34)35/h5-10,13-14,17,23H,2-4,11-12,15H2,1H3,(H,31,32)(H,33,36)(H,34,35)/t23-,29-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285506
PNG
(4-[4-Cyano-2-({[(2′R,4S)-7-methoxy-6-(methyl...)
Show SMILES CNC(=O)c1cc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)cc1OC
Show InChI InChI=1S/C26H27N3O6/c1-28-24(32)17-11-18-22(12-21(17)34-2)35-9-8-26(18)13-19(26)25(33)29-20-10-15(14-27)6-7-16(20)4-3-5-23(30)31/h6-7,10-12,19H,3-5,8-9,13H2,1-2H3,(H,28,32)(H,29,33)(H,30,31)/t19-,26-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM285485
PNG
(4-[4-Cyano-2-({[(2′R,4S)-6-phenyl-2,3-dihydr...)
Show SMILES OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)-c1ccccc1)C#N
Show InChI InChI=1S/C29H26N2O4/c30-18-19-9-10-21(7-4-8-27(32)33)25(15-19)31-28(34)24-17-29(24)13-14-35-26-12-11-22(16-23(26)29)20-5-2-1-3-6-20/h1-3,5-6,9-12,15-16,24H,4,7-8,13-14,17H2,(H,31,34)(H,32,33)/t24-,29-/m0/s1
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US Patent


Assay Description
EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...


US Patent US10077247 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%