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Patent code US10077272

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285641
PNG
((+)-5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylph...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)n[nH]c(=O)c1C
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
30.7n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285644
PNG
(4,6-Dimethyl-5-[2-methyl-4-([1,2]thiazolo[4,5-c]py...)
Show SMILES Cc1cc(Oc2nccc3sncc23)ccc1-c1c(C)n[nH]c(=O)c1C
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
32.7n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285642
PNG
((-)-5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylph...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)n[nH]c(=O)c1C
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
40.2n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285640
PNG
(5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)n[nH]c(=O)c1C
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
44.7n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285647
PNG
(5-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]-4,6-dim...)
Show SMILES Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2ncnc3occc23)cc1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
70.3n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285655
PNG
(1-cyclopropyl-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)p...)
Show SMILES Cc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(C2CC2)c(=O)[nH]c1=O
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
122n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285638
PNG
((-)-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylph...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C19H16N4O3/c1-11-8-13(26-19-15-6-7-25-18(15)21-10-22-19)4-5-14(11)17-12(2)20-9-16(24)23(17)3/h4-10H,1-3H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
127n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285656
PNG
(1-cyclopropyl-5-ethyl-6-[4-(furo[2,3-d]pyrimidin-4...)
Show SMILES CCc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(C2CC2)c(=O)[nH]c1=O
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
142n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285643
PNG
(6-[4-(Furo[2,3-d]pyrimidin-4-yloxy)phenyl]-1,5-dim...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
142n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285635
PNG
(4-[4-(4,6-Dimethylpyrimidin-5-yl)-3-methylphenoxy]...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)ncnc1C
Show InChI InChI=1S/C19H16N4O2/c1-11-8-14(25-19-16-6-7-24-18(16)22-10-23-19)4-5-15(11)17-12(2)20-9-21-13(17)3/h4-10H,1-3H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
166n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285654
PNG
(1-ethyl-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]...)
Show SMILES CCn1c(-c2ccc(Oc3ncnc4occc34)cc2)c(C)c(=O)[nH]c1=O
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
179n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285637
PNG
(6-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C19H16N4O3/c1-11-8-13(26-19-15-6-7-25-18(15)21-10-22-19)4-5-14(11)17-12(2)20-9-16(24)23(17)3/h4-10H,1-3H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
196n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285652
PNG
(5-ethyl-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]...)
Show SMILES CCc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(C)c(=O)[nH]c1=O
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
274n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285649
PNG
(1,5-dimethyl-6-{4-[(3-methyl[1,2]oxazolo[4,5-c]pyr...)
Show SMILES Cc1noc2ccnc(Oc3ccc(cc3)-c3c(C)c(=O)[nH]c(=O)n3C)c12
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
280n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285657
PNG
(1,5-diethyl-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)phe...)
Show SMILES CCc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(CC)c(=O)[nH]c1=O
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
309n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285650
PNG
(4,6-dimethyl-5-{2-methyl-4-[(3-methyl[1,2]oxazolo[...)
Show SMILES Cc1noc2ccnc(Oc3ccc(c(C)c3)-c3c(C)n[nH]c(=O)c3C)c12
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
326n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285646
PNG
(5-[4-(1H-imidazo[4,5-c]pyridin-4-yloxy)-2-methylph...)
Show SMILES Cc1cc(Oc2nccc3[nH]cnc23)ccc1-c1c(C)ncnc1C#N
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
367n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285648
PNG
(5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1cn[nH]c(=O)c1C
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
372n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285636
PNG
(4-[3-Methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)...)
Show SMILES Cc1cc(Oc2nccc3[nH]cnc23)ccc1-c1c(C)ncnc1C
KEGG

UniProtKB/SwissProt

DrugBank
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UniChem
374n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285639
PNG
((+)-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylph...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C19H16N4O3/c1-11-8-13(26-19-15-6-7-25-18(15)21-10-22-19)4-5-14(11)17-12(2)20-9-16(24)23(17)3/h4-10H,1-3H3
KEGG

UniProtKB/SwissProt

DrugBank
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UniChem
400n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285653
PNG
(6-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]-1-(2-me...)
Show SMILES COCCn1c(-c2ccc(Oc3ncnc4occc34)cc2)c(C)c(=O)[nH]c1=O
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
UniChem
900n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285645
PNG
(4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]...)
Show SMILES Cc1cc(Oc2nccc3[nH]cnc23)ccc1-c1c(C)ncnc1C
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
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UniChem
912n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM285651
PNG
(1,5-dimethyl-6-{2-methyl-4-[(3-methyl[1,2]oxazolo[...)
Show SMILES Cc1noc2ccnc(Oc3ccc(c(C)c3)-c3c(C)ncc(=O)n3C)c12
Show InChI InChI=1S/C20H18N4O3/c1-11-9-14(26-20-18-12(2)23-27-16(18)7-8-21-20)5-6-15(11)19-13(3)22-10-17(25)24(19)4/h5-10H,1-4H3
KEGG

UniProtKB/SwissProt

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1.73E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US10077272 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%