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Patent code US10077273

Compile Data Set for Download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285658
PNG
(US10077273, Compound 4)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(O)=O
PDB

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UniChem
n/an/a 0.170n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285663
PNG
(US10077273, Compound 11)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O
PDB
MMDB

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n/an/a 0.400n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285659
PNG
(US10077273, Compound 68)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N
PDB

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n/an/a 0.400n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285660
PNG
(US10077273, Compound 1)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCO
PDB

GoogleScholar
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UniChem
n/an/a 0.650n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285660
PNG
(US10077273, Compound 1)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCO
PDB

GoogleScholar
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UniChem
n/an/a 0.790n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285661
PNG
(US10077273, Compound 69)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)N[C@@H](CCC(O)=O)C(O)=O
PDB

GoogleScholar
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UniChem
n/an/a 0.800n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285662
PNG
(US10077273, Compound 70)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)N[C@H](CCC(O)=O)C(O)=O
PDB

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UniChem
n/an/a 1n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285663
PNG
(US10077273, Compound 11)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O
PDB

GoogleScholar
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UniChem
n/an/a 1.40n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285659
PNG
(US10077273, Compound 68)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N
PDB
MMDB

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n/an/a 1.70n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285664
PNG
(US10077273, Compound 71)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCCO)C#N
PDB

GoogleScholar
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n/an/a 1.70n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285666
PNG
(US10077273, Compound 2)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCO
PDB
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n/an/a 2n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285665
PNG
(US10077273, Compound 72)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)NC(C)(C)C(O)=O
PDB

GoogleScholar
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n/an/a 2n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285664
PNG
(US10077273, Compound 71)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCCO)C#N
PDB
MMDB

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n/an/a 2.40n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285666
PNG
(US10077273, Compound 2)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCO
PDB

GoogleScholar
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n/an/a 4n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285665
PNG
(US10077273, Compound 72)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)NC(C)(C)C(O)=O
PDB
MMDB

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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
PDB
MMDB

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n/an/a 5n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
PDB
MMDB

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n/an/a 5n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285688
PNG
(US10077273, Compound HK-X2)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1
PDB
MMDB

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n/an/a 5n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285667
PNG
(US10077273, Compound 73)
Show SMILES COC(=O)CCC#Cc1cc(cc(c1)C1(C(C)C)c2c(C)n[nH]c2OC(N)=C1C#N)C(F)(F)F
PDB

GoogleScholar
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UniChem
n/an/a 7.5n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285689
PNG
(US10077273, Compound HK-X3)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1cccc(CC(N)=O)c1
PDB

GoogleScholar
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UniChem
n/an/a 7.80n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285668
PNG
(US10077273, Compound 8)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN
PDB
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n/an/a 8n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285688
PNG
(US10077273, Compound HK-X2)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1
PDB

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n/an/a 13n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285687
PNG
(US10077273, Compound HK-X1)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1
PDB
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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
PDB

GoogleScholar
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n/an/a 15n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
PDB

GoogleScholar
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UniChem
n/an/a 15n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285689
PNG
(US10077273, Compound HK-X3)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1cccc(CC(N)=O)c1
PDB
MMDB

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n/an/a 16.9n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285669
PNG
(US10077273, Compound 74)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)C#CCCCO
PDB
MMDB

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The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285669
PNG
(US10077273, Compound 74)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)C#CCCCO
PDB

GoogleScholar
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UniChem
n/an/a 19n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285685
PNG
(US10077273, Compound HK-15)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(c1)C(F)(F)F
PDB
MMDB

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n/an/a 20n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
PDB
MMDB

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n/an/a 21n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285686
PNG
(US10077273, Compound HK-16 | US10077273, Compound ...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 27n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285685
PNG
(US10077273, Compound HK-15)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(c1)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 35n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285690
PNG
(Preparation of 6-amino-4-(3-bromo-5-(trifluorometh...)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Br)cc(c1)C(F)(F)F
PDB

GoogleScholar
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UniChem
n/an/a 42n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285668
PNG
(US10077273, Compound 8)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 43n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285687
PNG
(US10077273, Compound HK-X1)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 66n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285684
PNG
(US10077273, Compound HK-14)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(Cl)c1
PDB
MMDB

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n/an/a 67n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285681
PNG
(US10077273, Compound HK-11)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(Cl)cc(c1)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 100n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285684
PNG
(US10077273, Compound HK-14)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(Cl)c1
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 131n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285682
PNG
(US10077273, Compound HK-12)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 168n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285682
PNG
(US10077273, Compound HK-12)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
PDB
MMDB

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n/an/a 206n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285677
PNG
(US10077273, Compound HK-7)
Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cccc(Cl)c1
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 400n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285678
PNG
(US10077273, Compound HK-8)
Show SMILES CC(C)[C@]1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cccc(c1)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 400n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285683
PNG
(US10077273, Compound HK-13)
Show SMILES COc1cc(Cl)cc(c1)C1(C(C)C)c2c(C)n[nH]c2OC(N)=C1C#N
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 500n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285680
PNG
(US10077273, Compound HK-10)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(Cl)cc(Cl)c1
PDB
MMDB

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n/an/a 593n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285675
PNG
(US10077273, Compound HK-5)
Show SMILES CC(C)[C@@]1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cccc(c1)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 756n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285673
PNG
(US10077273, Compound HK-3)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cccc(Cl)c1
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 1.19E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285680
PNG
(US10077273, Compound HK-10)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(Cl)cc(Cl)c1
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 1.19E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285674
PNG
(US10077273, Compound HK-4)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)[C@@](C3CCC3)(c12)c1cccc(c1)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 1.77E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285679
PNG
(US10077273, Compound HK-9)
Show SMILES COc1cc(Cl)cc(c1)C1(C2CCC2)c2c(C)n[nH]c2OC(N)=C1C#N
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 3.46E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285676
PNG
(US10077273, Compound HK-6)
Show SMILES COc1cccc(c1)C1(C(C)C)c2c(C)n[nH]c2OC(N)=C1C#N
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 4.58E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285672
PNG
(US10077273, Compound HK-2)
Show SMILES COc1cccc(c1)C1(C2CCC2)c2c(C)n[nH]c2OC(N)=C1C#N
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a>5.00E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285671
PNG
(US10077273, Compound HK-1)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)[C@](C3CCC3)(c12)c1cccc(c1)C(F)(F)F
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a>5.00E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic


(Homo sapiens)
BDBM285672
PNG
(US10077273, Compound HK-2)
Show SMILES COc1cccc(c1)C1(C2CCC2)c2c(C)n[nH]c2OC(N)=C1C#N
PDB
MMDB

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n/an/a>5.00E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial


(Homo sapiens (human))
BDBM285670
PNG
(US10077273, Compound GD-07)
Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C)(c12)c1cccc(c1)[N+]([O-])=O
PDB

GoogleScholar
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UniChem
n/an/a>5.00E+3n/an/an/an/an/an/a



The Trustees of Princeton University

US Patent


Assay Description
For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...


US Patent US10077273 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%