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Patent code US10087143

Compile Data Set for Download or QSAR
Found 160 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161329
PNG
(US10087143, Compound 114 | US9051270, 114 | US9163...)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13Cl2FN2O4/c1-27-17-6-10(22)2-3-15(17)28-16-9-14(21)13(20)8-12(16)19(26)24-11-4-5-23-18(25)7-11/h2-9H,1H3,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161373
PNG
(US10087143, Compound 158 | US9051270, 158)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-17-9-12(21)3-5-15(17)30-16-8-11(20(22,23)24)2-4-14(16)19(28)26-13-6-7-25-18(27)10-13/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161326
PNG
(US10087143, Compound 111 | US9051270, 111 | US9163...)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C21H14F6N2O4/c1-32-17-9-12(22)3-5-15(17)33-16-8-11(20(23,24)21(25,26)27)2-4-14(16)19(31)29-13-6-7-28-18(30)10-13/h2-10H,1H3,(H2,28,29,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161369
PNG
(US10087143, Compound 154 | US9051270, 154)
Show SMILES COc1cc(F)ccc1Oc1cc(cc(c1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H13F7N2O4/c1-33-15-8-11(22)2-3-14(15)34-16-7-10(20(23,24)25)6-13(21(26,27)28)18(16)19(32)30-12-4-5-29-17(31)9-12/h2-9H,1H3,(H2,29,30,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161328
PNG
(US10087143, Compound 113 | US9051270, 113 | US9163...)
Show SMILES Fc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-14-8-13(18(25)23-11-5-6-22-17(24)7-11)16(9-15(14)20)26-12-3-1-10(21)2-4-12/h1-9H,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161330
PNG
(US10087143, Compound 115 | US9051270, 115)
Show SMILES COc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1F
Show InChI InChI=1S/C19H13Cl2FN2O4/c1-27-16-3-2-11(7-15(16)22)28-17-9-14(21)13(20)8-12(17)19(26)24-10-4-5-23-18(25)6-10/h2-9H,1H3,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161368
PNG
(US10087143, Compound 153 | US9051270, 153)
Show SMILES Cc1cc(F)ccc1Oc1cc(cc(c1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H13F7N2O3/c1-10-6-12(22)2-3-15(10)33-16-8-11(20(23,24)25)7-14(21(26,27)28)18(16)19(32)30-13-4-5-29-17(31)9-13/h2-9H,1H3,(H2,29,30,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161370
PNG
(US10087143, Compound 155 | US9051270, 155)
Show SMILES Fc1ccc(Oc2cc(cc(c2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C20H11F7N2O3/c21-11-1-3-13(4-2-11)32-15-8-10(19(22,23)24)7-14(20(25,26)27)17(15)18(31)29-12-5-6-28-16(30)9-12/h1-9H,(H2,28,29,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM287993
PNG
(US10087143, Compound 79)
Show SMILES F[B](F)(F)c1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161245
PNG
(US10087143, Compound 30 | US9051270, 30 | US916304...)
Show SMILES COc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-17-9-12(21)3-5-16(17)30-15-4-2-11(20(22,23)24)8-14(15)19(28)26-13-6-7-25-18(27)10-13/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161303
PNG
(US10087143, Compound 88 | US9051270, 88 | US916304...)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)C(F)(F)F)cc1
Show InChI InChI=1S/C20H12F6N2O3/c21-12-2-4-14(5-3-12)31-16-9-11(19(22,23)20(24,25)26)1-6-15(16)18(30)28-13-7-8-27-17(29)10-13/h1-10H,(H2,27,28,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161287
PNG
(US10087143, Compound 72 | US9051270, 72 | US905127...)
Show SMILES FC(F)(F)Oc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-1-6-16(31-13-2-4-14(5-3-13)32-20(24,25)26)15(9-11)18(30)28-12-7-8-27-17(29)10-12/h1-10H,(H2,27,28,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM287984
PNG
(US10087143, Compound 70)
Show SMILES COc1cc(C)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161225
PNG
(US10087143, Compound 10 | US9051270, 10 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-9-12(20(22,23)24)2-4-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161231
PNG
(US10087143, Compound 16 | US9051270, 16)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-9-12(21)3-5-15(17)27-16-8-11(20)2-4-14(16)19(25)23-13-6-7-22-18(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161304
PNG
(US10087143, Compound 89 | US9051270, 89)
Show SMILES COc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)C(F)(F)F)cc1F
Show InChI InChI=1S/C21H14F6N2O4/c1-32-16-5-3-13(10-15(16)22)33-17-8-11(20(23,24)21(25,26)27)2-4-14(17)19(31)29-12-6-7-28-18(30)9-12/h2-10H,1H3,(H2,28,29,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM288026
PNG
(US10087143, Compound 112)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)[B](F)(F)F
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161246
PNG
(US10087143, Compound 106 | US9051270, 106 | US9051...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-4-2-12(20(22,23)24)9-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161278
PNG
(US10087143, Compound 63 | US9051270, 63)
Show SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C21H17F3N2O4/c1-12-9-15(29-2)4-6-17(12)30-18-5-3-13(21(22,23)24)10-16(18)20(28)26-14-7-8-25-19(27)11-14/h3-11H,1-2H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161265
PNG
(US10087143, Compound 50 | US9051270, 50)
Show SMILES Cc1cc(Cl)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14ClF3N2O3/c1-11-8-13(21)3-5-16(11)29-17-4-2-12(20(22,23)24)9-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161324
PNG
(US10087143, Compound 109 | US9051270, 109)
Show SMILES Fc1ccc(Oc2cc(Cl)c(F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C18H10Cl2F2N2O3/c19-12-8-16(27-15-2-1-9(21)5-13(15)20)11(7-14(12)22)18(26)24-10-3-4-23-17(25)6-10/h1-8H,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161259
PNG
(US10087143, Compound 44 | US9051270, 44)
Show SMILES CCOc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H17F3N2O4/c1-2-29-15-4-6-16(7-5-15)30-18-8-3-13(21(22,23)24)11-17(18)20(28)26-14-9-10-25-19(27)12-14/h3-12H,2H2,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM287963
PNG
(US10087143, Compound 49)
Show SMILES Cc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161305
PNG
(US10087143, Compound 90 | US9051270, 90)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C19H10F6N2O3/c20-12-2-4-14(17(22)16(12)21)30-13-3-1-9(19(23,24)25)7-11(13)18(29)27-10-5-6-26-15(28)8-10/h1-8H,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161296
PNG
(US10087143, Compound 81 | US9051270, 81)
Show SMILES COc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-16-5-3-13(10-15(16)21)30-17-8-11(20(22,23)24)2-4-14(17)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161302
PNG
(US10087143, Compound 87 | US9051270, 87)
Show SMILES COc1c(F)cccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-18-14(21)3-2-4-15(18)30-16-9-11(20(22,23)24)5-6-13(16)19(28)26-12-7-8-25-17(27)10-12/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161244
PNG
(US10087143, Compound 29 | US9051270, 29 | US916304...)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H11ClF4N2O3/c20-14-8-11(21)2-4-16(14)29-15-3-1-10(19(22,23)24)7-13(15)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161292
PNG
(US10087143, Compound 77 | US9051270, 77)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H11ClF4N2O3/c20-14-8-11(21)2-4-15(14)29-16-7-10(19(22,23)24)1-3-13(16)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161283
PNG
(US10087143, Compound 68 | US9051270, 68 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-4-2-12(20)9-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161269
PNG
(US10087143, Compound 54 | US9051270, 54)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-18-14(21)3-2-4-16(18)30-15-6-5-11(20(22,23)24)9-13(15)19(28)26-12-7-8-25-17(27)10-12/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161235
PNG
(US10087143, Compound 20 | US9051270, 20 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-9-12(20)2-4-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161293
PNG
(US10087143, Compound 78 | US9051270, 78)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(Oc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H12ClF3N2O3/c20-12-2-4-14(5-3-12)28-16-9-11(19(21,22)23)1-6-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161274
PNG
(US10087143, Compound 59 | US9051270, 59)
Show SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-17-5-3-13(10-15(17)21)30-16-4-2-11(20(22,23)24)8-14(16)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161277
PNG
(US10087143, Compound 62 | US9051270, 62)
Show SMILES CCCOc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N2O4/c1-2-11-30-18-5-3-4-6-19(18)31-17-8-7-14(22(23,24)25)12-16(17)21(29)27-15-9-10-26-20(28)13-15/h3-10,12-13H,2,11H2,1H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM287987
PNG
(US10087143, Compound 73)
Show SMILES FC(F)Oc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM287996
PNG
(US10087143, Compound 82)
Show SMILES FC(F)Oc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161281
PNG
(US10087143, Compound 66 | US9051270, 66 | US916304...)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-1-3-15(26-16-4-2-11(21)8-14(16)20)13(7-10)18(25)23-12-5-6-22-17(24)9-12/h1-9H,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161220
PNG
(US10087143, Compound 5 | US9051270, 5)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-4-14(5-3-12)28-16-9-11(19(21,22)23)1-6-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161255
PNG
(US10087143, Compound 40 | US9051270, 40)
Show SMILES Cc1cc(F)ccc1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-11-8-12(21)2-4-16(11)29-17-5-3-14(30-20(22,23)24)10-15(17)19(28)26-13-6-7-25-18(27)9-13/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161243
PNG
(US10087143, Compound 28 | US9051270, 28 | US916304...)
Show SMILES Cc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H15F3N2O3/c1-12-4-2-3-5-16(12)28-17-7-6-13(20(21,22)23)10-15(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161367
PNG
(US10087143, Compound 152 | US9051270, 152)
Show SMILES Fc1ccc(Oc2cc(cc(c2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H10F8N2O3/c21-10-1-2-14(13(22)7-10)33-15-6-9(19(23,24)25)5-12(20(26,27)28)17(15)18(32)30-11-3-4-29-16(31)8-11/h1-8H,(H2,29,30,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161298
PNG
(US10087143, Compound 83 | US9051270, 83)
Show SMILES FC(F)Oc1ccccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H13F5N2O4/c21-19(22)31-15-4-2-1-3-14(15)30-16-9-11(20(23,24)25)5-6-13(16)18(29)27-12-7-8-26-17(28)10-12/h1-10,19H,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161299
PNG
(US10087143, Compound 84 | US9051270, 84)
Show SMILES COc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-29-13-3-5-16(15(21)10-13)30-17-8-11(20(22,23)24)2-4-14(17)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161268
PNG
(US10087143, Compound 53 | US9051270, 53)
Show SMILES CCCOc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H19F3N2O4/c1-2-11-30-16-4-6-17(7-5-16)31-19-8-3-14(22(23,24)25)12-18(19)21(29)27-15-9-10-26-20(28)13-15/h3-10,12-13H,2,11H2,1H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161222
PNG
(US10087143, Compound 7 | US9051270, 7 | US9163042,...)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H11F5N2O3/c20-11-2-4-15(14(21)8-11)29-16-7-10(19(22,23)24)1-3-13(16)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161290
PNG
(US10087143, Compound 75 | US9051270, 75 | US916304...)
Show SMILES FC(F)(F)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-5-6-14(31-15-3-1-2-4-16(15)32-20(24,25)26)13(9-11)18(30)28-12-7-8-27-17(29)10-12/h1-10H,(H2,27,28,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161252
PNG
(US10087143, Compound 37 | US9051270, 37)
Show SMILES Fc1ccc(Oc2ccc(OC(F)(F)F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C19H11ClF4N2O4/c20-14-7-10(21)1-3-16(14)29-15-4-2-12(30-19(22,23)24)9-13(15)18(28)26-11-5-6-25-17(27)8-11/h1-9H,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161371
PNG
(US10087143, Compound 156 | US9051270, 156)
Show SMILES FC(F)(F)c1cc(Oc2ccccc2)c(C(=O)Nc2cc[nH]c(=O)c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C20H12F6N2O3/c21-19(22,23)11-8-14(20(24,25)26)17(15(9-11)31-13-4-2-1-3-5-13)18(30)28-12-6-7-27-16(29)10-12/h1-10H,(H2,27,28,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161273
PNG
(US10087143, Compound 58 | US9051270, 58)
Show SMILES FC(F)(F)c1ccc(Oc2ccc(Cl)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H12ClF3N2O3/c20-12-2-4-14(5-3-12)28-16-6-1-11(19(21,22)23)9-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161291
PNG
(US10087143, Compound 76 | US9051270, 76)
Show SMILES FC(F)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H13F5N2O4/c21-19(22)31-16-4-2-1-3-15(16)30-14-6-5-11(20(23,24)25)9-13(14)18(29)27-12-7-8-26-17(28)10-12/h1-10,19H,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161217
PNG
(US10087143, Compound 2 | US9051270, 2 | US9163042,...)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-4-14(5-3-12)28-16-6-1-11(19(21,22)23)9-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161226
PNG
(US10087143, Compound 11 | US9051270, 11)
Show SMILES Cc1ccccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H15F3N2O3/c1-12-4-2-3-5-16(12)28-17-10-13(20(21,22)23)6-7-15(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161372
PNG
(US10087143, Compound 157 | US9051270, 157)
Show SMILES OCc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c21-13-2-4-16(11(7-13)10-27)30-17-8-12(20(22,23)24)1-3-15(17)19(29)26-14-5-6-25-18(28)9-14/h1-9,27H,10H2,(H2,25,26,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161239
PNG
(US10087143, Compound 24 | US9051270, 24)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C19H11F5N2O3/c20-11-2-4-16(14(21)8-11)29-15-3-1-10(19(22,23)24)7-13(15)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161260
PNG
(US10087143, Compound 45 | US9051270, 45)
Show SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N2O4/c1-28-14-3-5-15(6-4-14)29-17-7-2-12(20(21,22)23)10-16(17)19(27)25-13-8-9-24-18(26)11-13/h2-11H,1H3,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161261
PNG
(US10087143, Compound 46 | US9051270, 46)
Show SMILES CCOc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N2O4/c1-2-29-17-5-3-4-6-18(17)30-16-8-7-13(21(22,23)24)11-15(16)20(28)26-14-9-10-25-19(27)12-14/h3-12H,2H2,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161229
PNG
(US10087143, Compound 14 | US9051270, 14)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-1-3-13(18(25)23-12-5-6-22-17(24)9-12)16(7-10)26-15-4-2-11(21)8-14(15)20/h1-9H,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161257
PNG
(US10087143, Compound 42 | US9051270, 42)
Show SMILES COc1cc(F)ccc1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H14F4N2O5/c1-29-17-8-11(21)2-4-16(17)30-15-5-3-13(31-20(22,23)24)10-14(15)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161253
PNG
(US10087143, Compound 38 | US9051270, 38)
Show SMILES Fc1ccc(Oc2ccc(OC(F)(F)F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C19H12F4N2O4/c20-11-1-3-13(4-2-11)28-16-6-5-14(29-19(21,22)23)10-15(16)18(27)25-12-7-8-24-17(26)9-12/h1-10H,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161282
PNG
(US10087143, Compound 67 | US9051270, 67)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H12ClFN2O3/c19-11-1-6-16(25-14-4-2-12(20)3-5-14)15(9-11)18(24)22-13-7-8-21-17(23)10-13/h1-10H,(H2,21,22,23,24)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161271
PNG
(US10087143, Compound 56 | US9051270, 56)
Show SMILES Cc1ccc(F)cc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O3/c1-11-2-4-13(21)9-17(11)29-16-5-3-12(20(22,23)24)8-15(16)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161270
PNG
(US10087143, Compound 55 | US9051270, 55)
Show SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-29-13-3-5-17(15(21)10-13)30-16-4-2-11(20(22,23)24)8-14(16)19(28)26-12-6-7-25-18(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161230
PNG
(US10087143, Compound 15 | US9051270, 15)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H12ClFN2O3/c19-11-1-6-15(18(24)22-13-7-8-21-17(23)10-13)16(9-11)25-14-4-2-12(20)3-5-14/h1-10H,(H2,21,22,23,24)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161356
PNG
(US10087143, Compound 141 | US9051270, 141)
Show SMILES CC(C)(C)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(Oc2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-21(2,3)13-4-6-16(20(30)28-14-8-9-26-19(29)11-14)17(10-13)31-15-5-7-18(27-12-15)22(23,24)25/h4-12H,1-3H3,(H2,26,28,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161266
PNG
(US10087143, Compound 51 | US9051270, 51)
Show SMILES Fc1cc(Cl)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H11ClF4N2O3/c20-11-2-4-16(14(21)8-11)29-15-3-1-10(19(22,23)24)7-13(15)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161286
PNG
(US10087143, Compound 71 | US9051270, 71)
Show SMILES COc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1F
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-5-3-13(10-15(17)21)27-16-4-2-11(20)8-14(16)19(25)23-12-6-7-22-18(24)9-12/h2-10H,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161224
PNG
(US10087143, Compound 9 | US9051270, 9)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(Oc2ccccc2)c1
Show InChI InChI=1S/C19H13F3N2O3/c20-19(21,22)12-6-7-15(16(10-12)27-14-4-2-1-3-5-14)18(26)24-13-8-9-23-17(25)11-13/h1-11H,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161267
PNG
(US10087143, Compound 52 | US9051270, 52)
Show SMILES COc1ccc(F)cc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-16-5-3-12(21)9-17(16)30-15-4-2-11(20(22,23)24)8-14(15)19(28)26-13-6-7-25-18(27)10-13/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161248
PNG
(US10087143, Compound 33 | US9051270, 33)
Show SMILES Fc1ccc(Oc2ccc(OC(F)(F)F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C19H11F5N2O4/c20-10-1-3-16(14(21)7-10)29-15-4-2-12(30-19(22,23)24)9-13(15)18(28)26-11-5-6-25-17(27)8-11/h1-9H,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161246
PNG
(US10087143, Compound 106 | US9051270, 106 | US9051...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-4-2-12(20(22,23)24)9-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161237
PNG
(US10087143, Compound 22 | US9051270, 22)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C#N
Show InChI InChI=1S/C20H14FN3O4/c1-27-18-9-13(21)3-5-16(18)28-17-8-12(11-22)2-4-15(17)20(26)24-14-6-7-23-19(25)10-14/h2-10H,1H3,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161251
PNG
(US10087143, Compound 36 | US9051270, 36)
Show SMILES Cc1ccccc1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H15F3N2O4/c1-12-4-2-3-5-16(12)28-17-7-6-14(29-20(21,22)23)11-15(17)19(27)25-13-8-9-24-18(26)10-13/h2-11H,1H3,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161295
PNG
(US10087143, Compound 80 | US9051270, 80)
Show SMILES FC(F)(F)Oc1ccccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-5-6-13(18(30)28-12-7-8-27-17(29)10-12)16(9-11)31-14-3-1-2-4-15(14)32-20(24,25)26/h1-10H,(H2,27,28,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161228
PNG
(US10087143, Compound 13 | US9051270, 13)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-1-3-13(18(25)23-12-5-6-22-17(24)9-12)16(7-10)26-15-4-2-11(20)8-14(15)21/h1-9H,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161227
PNG
(US10087143, Compound 12 | US9051270, 12)
Show SMILES Cc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N2O3/c1-12-2-5-15(6-3-12)28-17-10-13(20(21,22)23)4-7-16(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161280
PNG
(US10087143, Compound 65 | US9051270, 65)
Show SMILES FC(F)(F)c1ccc(Oc2ccccc2Cl)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H12ClF3N2O3/c20-14-3-1-2-4-16(14)28-15-6-5-11(19(21,22)23)9-13(15)18(27)25-12-7-8-24-17(26)10-12/h1-10H,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161279
PNG
(US10087143, Compound 64 | US9051270, 64)
Show SMILES CC(C)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N2O4/c1-13(2)30-18-5-3-4-6-19(18)31-17-8-7-14(22(23,24)25)11-16(17)21(29)27-15-9-10-26-20(28)12-15/h3-13H,1-2H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161284
PNG
(US10087143, Compound 69 | US9051270, 69)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-1-3-15(26-16-4-2-11(20)8-14(16)21)13(7-10)18(25)23-12-5-6-22-17(24)9-12/h1-9H,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161276
PNG
(US10087143, Compound 61 | US9051270, 61)
Show SMILES Cc1cc(NC(=O)c2cc(ccc2Oc2ccc(F)cc2C)C(F)(F)F)cc(=O)[nH]1
Show InChI InChI=1S/C21H16F4N2O3/c1-11-7-14(22)4-6-17(11)30-18-5-3-13(21(23,24)25)9-16(18)20(29)27-15-8-12(2)26-19(28)10-15/h3-10H,1-2H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161316
PNG
(US10087143, Compound 101 | US9051270, 101)
Show SMILES Fc1ccc(Oc2ccc(OC(F)(F)F)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H12F4N2O4/c20-11-1-6-16(28-13-2-4-14(5-3-13)29-19(21,22)23)15(9-11)18(27)25-12-7-8-24-17(26)10-12/h1-10H,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161275
PNG
(US10087143, Compound 60 | US9051270, 60)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc(Cl)[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H13ClF4N2O3/c1-10-6-12(22)3-5-15(10)30-16-4-2-11(20(23,24)25)7-14(16)19(29)26-13-8-17(21)27-18(28)9-13/h2-9H,1H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161307
PNG
(US10087143, Compound 92 | US9051270, 92)
Show SMILES Cc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1F
Show InChI InChI=1S/C20H13F5N2O3/c1-10-2-4-15(18(22)17(10)21)30-14-5-3-11(20(23,24)25)8-13(14)19(29)27-12-6-7-26-16(28)9-12/h2-9H,1H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161262
PNG
(US10087143, Compound 47 | US9051270, 47)
Show SMILES COc1cc(C)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N2O4/c1-12-3-5-17(18(9-12)29-2)30-16-6-4-13(21(22,23)24)10-15(16)20(28)26-14-7-8-25-19(27)11-14/h3-11H,1-2H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161335
PNG
(US10087143, Compound 120 | US9051270, 120)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OCC2CCCC2)c1
Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)13-5-6-15(16(9-13)27-11-12-3-1-2-4-12)18(26)24-14-7-8-23-17(25)10-14/h5-10,12H,1-4,11H2,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161315
PNG
(US10087143, Compound 100 | US9051270, 100)
Show SMILES CCCOc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C21H19FN2O4/c1-2-11-27-16-4-6-17(7-5-16)28-19-8-3-14(22)12-18(19)21(26)24-15-9-10-23-20(25)13-15/h3-10,12-13H,2,11H2,1H3,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161247
PNG
(US10087143, Compound 32 | US9051270, 32)
Show SMILES FC(F)(F)c1ccc(Oc2ccccc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13F3N2O3/c20-19(21,22)12-6-7-16(27-14-4-2-1-3-5-14)15(10-12)18(26)24-13-8-9-23-17(25)11-13/h1-11H,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161221
PNG
(US10087143, Compound 6 | US9051270, 6)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2ccc(=O)[nH]c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-5-14(6-3-12)28-16-9-11(19(21,22)23)1-7-15(16)18(27)25-13-4-8-17(26)24-10-13/h1-10H,(H,24,26)(H,25,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161256
PNG
(US10087143, Compound 41 | US9051270, 41)
Show SMILES FC(F)(F)Oc1ccc(Oc2ccccc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13F3N2O4/c20-19(21,22)28-14-6-7-16(27-13-4-2-1-3-5-13)15(11-14)18(26)24-12-8-9-23-17(25)10-12/h1-11H,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161323
PNG
(US10087143, Compound 108 | US9051270, 108)
Show SMILES Fc1ccc(Oc2ccc(OCC3CC3)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C22H19FN2O4/c23-15-3-8-20(19(11-15)22(27)25-16-9-10-24-21(26)12-16)29-18-6-4-17(5-7-18)28-13-14-1-2-14/h3-12,14H,1-2,13H2,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161313
PNG
(US10087143, Compound 98 | US9051270, 98)
Show SMILES CCOc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C20H17FN2O4/c1-2-26-15-4-6-16(7-5-15)27-18-8-3-13(21)11-17(18)20(25)23-14-9-10-22-19(24)12-14/h3-12H,2H2,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161347
PNG
(US10087143, Compound 132 | US9051270, 132)
Show SMILES FC(F)(F)CCOc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C16H12F6N2O3/c17-15(18,19)4-6-27-12-2-1-9(16(20,21)22)7-11(12)14(26)24-10-3-5-23-13(25)8-10/h1-3,5,7-8H,4,6H2,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161223
PNG
(US10087143, Compound 8 | US9051270, 8)
Show SMILES COCCOc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H19F3N2O5/c1-30-10-11-31-16-3-5-17(6-4-16)32-19-12-14(22(23,24)25)2-7-18(19)21(29)27-15-8-9-26-20(28)13-15/h2-9,12-13H,10-11H2,1H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161318
PNG
(US10087143, Compound 103 | US9051270, 103)
Show SMILES COc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-13-3-5-17(15(20)10-13)27-16-4-2-11(21)8-14(16)19(25)23-12-6-7-22-18(24)9-12/h2-10H,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161242
PNG
(US10087143, Compound 27 | US9051270, 27)
Show SMILES Cc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N2O3/c1-12-2-5-15(6-3-12)28-17-7-4-13(20(21,22)23)10-16(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161219
PNG
(US10087143, Compound 4 | US9051270, 4)
Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2ccc(=O)[nH]c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-5-14(6-3-12)28-16-7-1-11(19(21,22)23)9-15(16)18(27)25-13-4-8-17(26)24-10-13/h1-10H,(H,24,26)(H,25,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161338
PNG
(US10087143, Compound 123 | US9051270, 123)
Show SMILES FC(F)(F)CCCOc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)5-1-7-28-13-8-10(17(21,22)23)2-3-12(13)15(27)25-11-4-6-24-14(26)9-11/h2-4,6,8-9H,1,5,7H2,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161258
PNG
(US10087143, Compound 43 | US9051270, 43)
Show SMILES Fc1ccc(Oc2cccc(c2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H12F4N2O3/c20-11-4-6-13(7-5-11)28-15-3-1-2-14(19(21,22)23)17(15)18(27)25-12-8-9-24-16(26)10-12/h1-10H,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161322
PNG
(US10087143, Compound 107 | US9051270, 107)
Show SMILES Fc1ccc(Oc2ccc(OCC(F)(F)F)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H14F4N2O4/c21-12-1-6-17(16(9-12)19(28)26-13-7-8-25-18(27)10-13)30-15-4-2-14(3-5-15)29-11-20(22,23)24/h1-10H,11H2,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161311
PNG
(US10087143, Compound 96 | US9051270, 96)
Show SMILES Fc1ccc(Oc2ccc(cc2)C2CC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C21H17FN2O3/c22-15-5-8-19(27-17-6-3-14(4-7-17)13-1-2-13)18(11-15)21(26)24-16-9-10-23-20(25)12-16/h3-13H,1-2H2,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161306
PNG
(US10087143, Compound 91 | US9051270, 91)
Show SMILES Cc1cc(C)c(C)c(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H19F3N2O3/c1-12-8-13(2)14(3)19(9-12)30-18-5-4-15(22(23,24)25)10-17(18)21(29)27-16-6-7-26-20(28)11-16/h4-11H,1-3H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161363
PNG
(US10087143, Compound 148 | US9051270, 148)
Show SMILES Cn1ccc(NC(=O)c2ccc(cc2Oc2ccc(nc2)C(F)(F)F)C(C)(C)C)cc1=O
Show InChI InChI=1S/C23H22F3N3O3/c1-22(2,3)14-5-7-17(21(31)28-15-9-10-29(4)20(30)12-15)18(11-14)32-16-6-8-19(27-13-16)23(24,25)26/h5-13H,1-4H3,(H,28,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161250
PNG
(US10087143, Compound 35 | US9051270, 35)
Show SMILES Cc1ccc(Oc2ccc(OC(F)(F)F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C20H15F3N2O4/c1-12-2-4-14(5-3-12)28-17-7-6-15(29-20(21,22)23)11-16(17)19(27)25-13-8-9-24-18(26)10-13/h2-11H,1H3,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161339
PNG
(US10087143, Compound 124 | US9051270, 124)
Show SMILES CC1(C)CC1COc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N2O3/c1-18(2)9-12(18)10-27-15-7-11(19(20,21)22)3-4-14(15)17(26)24-13-5-6-23-16(25)8-13/h3-8,12H,9-10H2,1-2H3,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161331
PNG
(US10087143, Compound 116 | US9051270, 116)
Show SMILES CC(C)CCOc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N2O3/c1-11(2)6-8-26-15-9-12(18(19,20)21)3-4-14(15)17(25)23-13-5-7-22-16(24)10-13/h3-5,7,9-11H,6,8H2,1-2H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161343
PNG
(US10087143, Compound 128 | US9051270, 128)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2CCCCC2)c1
Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)12-6-7-15(16(10-12)27-14-4-2-1-3-5-14)18(26)24-13-8-9-23-17(25)11-13/h6-11,14H,1-5H2,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161359
PNG
(US10087143, Compound 144 | US9051270, 144)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(Oc2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C19H11F6N3O3/c20-18(21,22)10-1-3-13(17(30)28-11-5-6-26-16(29)8-11)14(7-10)31-12-2-4-15(27-9-12)19(23,24)25/h1-9H,(H2,26,28,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161357
PNG
(US10087143, Compound 142 | US9051270, 142)
Show SMILES CC(C)(C)c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c(Oc2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-21(2,3)13-4-7-16(20(30)28-14-5-9-19(29)27-11-14)17(10-13)31-15-6-8-18(26-12-15)22(23,24)25/h4-12H,1-3H3,(H,27,29)(H,28,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161254
PNG
(US10087143, Compound 39 | US9051270, 39)
Show SMILES Cc1cccc(F)c1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-11-3-2-4-15(21)18(11)29-16-6-5-13(30-20(22,23)24)10-14(16)19(28)26-12-7-8-25-17(27)9-12/h2-10H,1H3,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161312
PNG
(US10087143, Compound 97 | US9051270, 97)
Show SMILES CC(C)(C)Oc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C22H21FN2O4/c1-22(2,3)29-17-7-5-16(6-8-17)28-19-9-4-14(23)12-18(19)21(27)25-15-10-11-24-20(26)13-15/h4-13H,1-3H3,(H2,24,25,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161333
PNG
(US10087143, Compound 118 | US9051270, 118)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2C[C@H]3CCC2C3)c1
Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)13-3-4-15(19(27)25-14-5-6-24-18(26)10-14)17(9-13)28-16-8-11-1-2-12(16)7-11/h3-6,9-12,16H,1-2,7-8H2,(H2,24,25,26,27)/t11-,12?,16?/m0/s1
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161236
PNG
(US10087143, Compound 21 | US9051270, 21)
Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C#N)cc1
Show InChI InChI=1S/C19H12FN3O3/c20-13-2-4-15(5-3-13)26-17-9-12(11-21)1-6-16(17)19(25)23-14-7-8-22-18(24)10-14/h1-10H,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161325
PNG
(US10087143, Compound 110 | US9051270, 110)
Show SMILES COc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1F
Show InChI InChI=1S/C20H13ClF4N2O4/c1-30-14-5-4-13(17(21)18(14)22)31-15-8-10(20(23,24)25)2-3-12(15)19(29)27-11-6-7-26-16(28)9-11/h2-9H,1H3,(H2,26,27,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161344
PNG
(US10087143, Compound 129 | US9051270, 129)
Show SMILES FC(F)(F)CCCOc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C16H14ClF3N2O3/c17-10-2-3-12(13(8-10)25-7-1-5-16(18,19)20)15(24)22-11-4-6-21-14(23)9-11/h2-4,6,8-9H,1,5,7H2,(H2,21,22,23,24)
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n/an/a 940n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161216
PNG
(US10087143, Compound 1 | US9051270, 1)
Show SMILES Fc1ccc(Oc2ccccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H13FN2O3/c19-12-5-7-14(8-6-12)24-16-4-2-1-3-15(16)18(23)21-13-9-10-20-17(22)11-13/h1-11H,(H2,20,21,22,23)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161240
PNG
(US10087143, Compound 25 | US9051270, 25)
Show SMILES FC(F)(F)c1ccc(Oc2ccc(cc2)[N+]#[C-])c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H12F3N3O3/c1-24-13-3-5-15(6-4-13)29-17-7-2-12(20(21,22)23)10-16(17)19(28)26-14-8-9-25-18(27)11-14/h2-11H,(H2,25,26,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161332
PNG
(US10087143, Compound 117 | US9051270, 117)
Show SMILES CC(C)COc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N2O3/c1-10(2)9-25-14-7-11(17(18,19)20)3-4-13(14)16(24)22-12-5-6-21-15(23)8-12/h3-8,10H,9H2,1-2H3,(H2,21,22,23,24)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161319
PNG
(US10087143, Compound 104 | US9051270, 104)
Show SMILES COc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C19H15FN2O4/c1-25-14-3-5-15(6-4-14)26-17-7-2-12(20)10-16(17)19(24)22-13-8-9-21-18(23)11-13/h2-11H,1H3,(H2,21,22,23,24)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161342
PNG
(US10087143, Compound 127 | US9051270, 127)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2CC3CCC2C3)c1
Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)13-3-4-15(19(27)25-14-5-6-24-18(26)10-14)17(9-13)28-16-8-11-1-2-12(16)7-11/h3-6,9-12,16H,1-2,7-8H2,(H2,24,25,26,27)
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n/an/a 1.30E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161375
PNG
(US10087143, Compound 160 | US9051270, 160)
Show SMILES Fc1ccc(Oc2ccc(OCCCC(F)(F)F)cc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C22H18F4N2O4/c23-14-2-7-19(18(12-14)21(30)28-15-8-10-27-20(29)13-15)32-17-5-3-16(4-6-17)31-11-1-9-22(24,25)26/h2-8,10,12-13H,1,9,11H2,(H2,27,28,29,30)
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n/an/a 1.39E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161309
PNG
(US10087143, Compound 94 | US9051270, 94)
Show SMILES Cc1cc(C)c(C)c(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)c1
Show InChI InChI=1S/C21H19FN2O3/c1-12-8-13(2)14(3)19(9-12)27-18-5-4-15(22)10-17(18)21(26)24-16-6-7-23-20(25)11-16/h4-11H,1-3H3,(H2,23,24,25,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161341
PNG
(US10087143, Compound 126 | US9051270, 126)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OCC2CC2(F)F)c1
Show InChI InChI=1S/C17H13F5N2O3/c18-16(19)7-10(16)8-27-13-5-9(17(20,21)22)1-2-12(13)15(26)24-11-3-4-23-14(25)6-11/h1-6,10H,7-8H2,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161308
PNG
(US10087143, Compound 93 | US9051270, 93)
Show SMILES Cc1cc(C)c(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1C
Show InChI InChI=1S/C22H19F3N2O3/c1-12-8-14(3)19(9-13(12)2)30-18-5-4-15(22(23,24)25)10-17(18)21(29)27-16-6-7-26-20(28)11-16/h4-11H,1-3H3,(H2,26,27,28,29)
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n/an/a 1.45E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161353
PNG
(US10087143, Compound 138 | US9051270, 138)
Show SMILES FC(F)(F)CCOc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C16H12F6N2O4/c17-15(18,19)4-6-27-12-2-1-10(28-16(20,21)22)8-11(12)14(26)24-9-3-5-23-13(25)7-9/h1-3,5,7-8H,4,6H2,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161346
PNG
(US10087143, Compound 131 | US9051270, 131)
Show SMILES CC(C)COc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N2O3/c1-10(2)9-25-14-4-3-11(17(18,19)20)7-13(14)16(24)22-12-5-6-21-15(23)8-12/h3-8,10H,9H2,1-2H3,(H2,21,22,23,24)
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n/an/a 1.50E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161238
PNG
(US10087143, Compound 23 | US9051270, 23)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C#N
Show InChI InChI=1S/C20H14FN3O3/c1-12-8-14(21)3-5-17(12)27-18-9-13(11-22)2-4-16(18)20(26)24-15-6-7-23-19(25)10-15/h2-10H,1H3,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161350
PNG
(US10087143, Compound 135 | US9051270, 135)
Show SMILES FC(F)(F)c1ccc(OC2C[C@@H]3C[C@@H]3C2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)12-1-2-16(27-14-6-10-5-11(10)7-14)15(8-12)18(26)24-13-3-4-23-17(25)9-13/h1-4,8-11,14H,5-7H2,(H2,23,24,25,26)/t10-,11+,14?
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n/an/a 1.65E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161364
PNG
(US10087143, Compound 149 | US9051270, 149)
Show SMILES Cn1cc(NC(=O)c2ccc(cc2Oc2ccc(nc2)C(F)(F)F)C(C)(C)C)ccc1=O
Show InChI InChI=1S/C23H22F3N3O3/c1-22(2,3)14-5-8-17(21(31)28-15-6-10-20(30)29(4)13-15)18(11-14)32-16-7-9-19(27-12-16)23(24,25)26/h5-13H,1-4H3,(H,28,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161232
PNG
(US10087143, Compound 17 | US9051270, 17)
Show SMILES Cc1cccc(F)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-3-2-4-15(21)18(11)26-16-9-12(20)5-6-14(16)19(25)23-13-7-8-22-17(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161374
PNG
(US10087143, Compound 159 | US9051270, 159)
Show SMILES Oc1ccc(F)cc1COc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c21-13-2-4-16(27)11(7-13)10-30-17-8-12(20(22,23)24)1-3-15(17)19(29)26-14-5-6-25-18(28)9-14/h1-9,27H,10H2,(H2,25,26,28,29)
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n/an/a 2.60E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161351
PNG
(US10087143, Compound 136 | US9051270, 136)
Show SMILES FC(F)(F)Oc1ccc(OCC2CCCC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H19F3N2O4/c20-19(21,22)28-14-5-6-16(27-11-12-3-1-2-4-12)15(10-14)18(26)24-13-7-8-23-17(25)9-13/h5-10,12H,1-4,11H2,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161263
PNG
(US10087143, Compound 48 | US9051270, 48)
Show SMILES COc1cccc(F)c1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C20H14F4N2O4/c1-29-16-4-2-3-14(21)18(16)30-15-6-5-11(20(22,23)24)9-13(15)19(28)26-12-7-8-25-17(27)10-12/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 2.70E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161300
PNG
(US10087143, Compound 85 | US9051270, 85)
Show SMILES OCCn1ccc(NC(=O)c2ccc(cc2Oc2ccc(F)cc2)C(F)(F)F)cc1=O
Show InChI InChI=1S/C21H16F4N2O4/c22-14-2-4-16(5-3-14)31-18-11-13(21(23,24)25)1-6-17(18)20(30)26-15-7-8-27(9-10-28)19(29)12-15/h1-8,11-12,28H,9-10H2,(H,26,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161354
PNG
(US10087143, Compound 139 | US9051270, 139)
Show SMILES FC(F)(F)CCCOc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C17H14F6N2O4/c18-16(19,20)5-1-7-28-13-3-2-11(29-17(21,22)23)9-12(13)15(27)25-10-4-6-24-14(26)8-10/h2-4,6,8-9H,1,5,7H2,(H2,24,25,26,27)
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n/an/a 3.05E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161358
PNG
(US10087143, Compound 143 | US9051270, 143)
Show SMILES FC(F)(F)c1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)cn1
Show InChI InChI=1S/C18H11ClF3N3O3/c19-10-1-3-13(17(27)25-11-5-6-23-16(26)8-11)14(7-10)28-12-2-4-15(24-9-12)18(20,21)22/h1-9H,(H2,23,25,26,27)
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n/an/a 3.35E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161310
PNG
(US10087143, Compound 95 | US9051270, 95)
Show SMILES Fc1ccc(Oc2ccccc2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H13FN2O3/c19-12-6-7-16(24-14-4-2-1-3-5-14)15(10-12)18(23)21-13-8-9-20-17(22)11-13/h1-11H,(H2,20,21,22,23)
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n/an/a 3.45E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161301
PNG
(US10087143, Compound 86 | US9051270, 86)
Show SMILES Cc1c[nH]c(=O)cc1NC(=O)c1ccc(cc1Oc1ccc(F)cc1C)C(F)(F)F
Show InChI InChI=1S/C21H16F4N2O3/c1-11-7-14(22)4-6-17(11)30-18-8-13(21(23,24)25)3-5-15(18)20(29)27-16-9-19(28)26-10-12(16)2/h3-10H,1-2H3,(H2,26,27,28,29)
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n/an/a 3.55E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161320
PNG
(US10087143, Compound 105 | US9051270, 105)
Show SMILES Cc1cc(C)c(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1C
Show InChI InChI=1S/C21H19FN2O3/c1-12-8-14(3)19(9-13(12)2)27-18-5-4-15(22)10-17(18)21(26)24-16-6-7-23-20(25)11-16/h4-11H,1-3H3,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161362
PNG
(US10087143, Compound 147 | US9051270, 147)
Show SMILES Cc1ncccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H14F3N3O3/c1-11-15(3-2-7-23-11)28-16-9-12(19(20,21)22)4-5-14(16)18(27)25-13-6-8-24-17(26)10-13/h2-10H,1H3,(H2,24,25,26,27)
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n/an/a 3.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161337
PNG
(US10087143, Compound 122 | US9051270, 122)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2CCC2)c1
Show InChI InChI=1S/C17H15F3N2O3/c18-17(19,20)10-4-5-13(14(8-10)25-12-2-1-3-12)16(24)22-11-6-7-21-15(23)9-11/h4-9,12H,1-3H2,(H2,21,22,23,24)
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n/an/a 4.20E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161361
PNG
(US10087143, Compound 146 | US9051270, 146)
Show SMILES Cc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cn1
Show InChI InChI=1S/C19H14F3N3O3/c1-11-2-4-14(10-24-11)28-16-8-12(19(20,21)22)3-5-15(16)18(27)25-13-6-7-23-17(26)9-13/h2-10H,1H3,(H2,23,25,26,27)
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n/an/a 4.60E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161360
PNG
(US10087143, Compound 145 | US9051270, 145)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c(Oc2ccc(nc2)C(F)(F)F)c1
Show InChI InChI=1S/C19H11F6N3O3/c20-18(21,22)10-1-4-13(17(30)28-11-2-6-16(29)27-8-11)14(7-10)31-12-3-5-15(26-9-12)19(23,24)25/h1-9H,(H,27,29)(H,28,30)
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n/an/a 5.00E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161345
PNG
(US10087143, Compound 130 | US9051270, 130)
Show SMILES FC(F)(F)c1ccc(OCC2CCCC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)13-5-6-16(27-11-12-3-1-2-4-12)15(9-13)18(26)24-14-7-8-23-17(25)10-14/h5-10,12H,1-4,11H2,(H2,23,24,25,26)
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n/an/a 5.10E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161314
PNG
(US10087143, Compound 99 | US9051270, 99)
Show SMILES CC(C)c1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C21H19FN2O3/c1-13(2)14-3-6-17(7-4-14)27-19-8-5-15(22)11-18(19)21(26)24-16-9-10-23-20(25)12-16/h3-13H,1-2H3,(H2,23,24,25,26)
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n/an/a 5.15E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161289
PNG
(US10087143, Compound 74 | US9051270, 74)
Show SMILES FC(F)(F)c1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H12F6N2O3/c21-19(22,23)11-1-4-14(5-2-11)31-16-6-3-12(20(24,25)26)9-15(16)18(30)28-13-7-8-27-17(29)10-13/h1-10H,(H2,27,28,29,30)
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n/an/a 5.18E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161348
PNG
(US10087143, Compound 133 | US9051270, 133)
Show SMILES FC(F)(F)CCCOc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)5-1-7-28-13-3-2-10(17(21,22)23)8-12(13)15(27)25-11-4-6-24-14(26)9-11/h2-4,6,8-9H,1,5,7H2,(H2,24,25,26,27)
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n/an/a 5.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161234
PNG
(US10087143, Compound 19 | US9051270, 19)
Show SMILES Fc1cccc(F)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-4-5-12(18(25)23-11-6-7-22-16(24)9-11)15(8-10)26-17-13(20)2-1-3-14(17)21/h1-9H,(H2,22,23,24,25)
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n/an/a 6.00E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161365
PNG
(US10087143, Compound 150 | US9051270, 150)
Show SMILES Cc1ncccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H14F3N3O3/c1-11-15(3-2-7-23-11)28-16-5-4-12(19(20,21)22)9-14(16)18(27)25-13-6-8-24-17(26)10-13/h2-10H,1H3,(H2,24,25,26,27)
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n/an/a 6.60E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161272
PNG
(US10087143, Compound 57 | US9051270, 57)
Show SMILES COc1cc(F)cc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c1
Show InChI InChI=1S/C20H14F4N2O4/c1-29-14-7-12(21)8-15(10-14)30-17-3-2-11(20(22,23)24)6-16(17)19(28)26-13-4-5-25-18(27)9-13/h2-10H,1H3,(H2,25,26,27,28)
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n/an/a 6.90E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161366
PNG
(US10087143, Compound 151 | US9051270, 151)
Show SMILES Cc1ncccc1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14F3N3O4/c1-11-15(3-2-7-23-11)28-16-5-4-13(29-19(20,21)22)10-14(16)18(27)25-12-6-8-24-17(26)9-12/h2-10H,1H3,(H2,24,25,26,27)
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n/an/a 8.40E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161241
PNG
(US10087143, Compound 26 | US9051270, 26)
Show SMILES Fc1cccc(F)c1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H11F5N2O3/c20-13-2-1-3-14(21)17(13)29-15-5-4-10(19(22,23)24)8-12(15)18(28)26-11-6-7-25-16(27)9-11/h1-9H,(H2,25,26,27,28)
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n/an/a 9.65E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161249
PNG
(US10087143, Compound 34 | US9051270, 34)
Show SMILES Fc1cccc(F)c1Oc1ccc(OC(F)(F)F)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H11F5N2O4/c20-13-2-1-3-14(21)17(13)29-15-5-4-11(30-19(22,23)24)9-12(15)18(28)26-10-6-7-25-16(27)8-10/h1-9H,(H2,25,26,27,28)
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n/an/a 1.20E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161233
PNG
(US10087143, Compound 18 | US9051270, 18)
Show SMILES Fc1cccc(Cl)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-4-5-12(18(25)23-11-6-7-22-16(24)9-11)15(8-10)26-17-13(20)2-1-3-14(17)21/h1-9H,(H2,22,23,24,25)
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n/an/a 1.20E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161352
PNG
(US10087143, Compound 137 | US9051270, 137)
Show SMILES FC(F)(F)Oc1ccc(OC2CCCCC2)c(c1)C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H19F3N2O4/c20-19(21,22)28-14-6-7-16(27-13-4-2-1-3-5-13)15(11-14)18(26)24-12-8-9-23-17(25)10-12/h6-11,13H,1-5H2,(H2,23,24,25,26)
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n/an/a 1.27E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161218
PNG
(US10087143, Compound 3 | US9051270, 3)
Show SMILES Fc1ccc(Oc2ccccc2C(=O)Nc2ccc(=O)[nH]c2)cc1
Show InChI InChI=1S/C18H13FN2O3/c19-12-5-8-14(9-6-12)24-16-4-2-1-3-15(16)18(23)21-13-7-10-17(22)20-11-13/h1-11H,(H,20,22)(H,21,23)
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n/an/a 1.35E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161334
PNG
(US10087143, Compound 119 | US9051270, 119)
Show SMILES CC1(COc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)CC1
Show InChI InChI=1S/C18H17F3N2O3/c1-17(5-6-17)10-26-14-8-11(18(19,20)21)2-3-13(14)16(25)23-12-4-7-22-15(24)9-12/h2-4,7-9H,5-6,10H2,1H3,(H2,22,23,24,25)
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n/an/a 1.40E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161349
PNG
(US10087143, Compound 140 | US9051270, 134)
Show SMILES CC1(C)CC1COc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N2O3/c1-18(2)9-12(18)10-27-15-4-3-11(19(20,21)22)7-14(15)17(26)24-13-5-6-23-16(25)8-13/h3-8,12H,9-10H2,1-2H3,(H2,23,24,25,26)
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n/an/a 1.50E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161317
PNG
(US10087143, Compound 102 | US9051270, 102)
Show SMILES COCCc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C21H19FN2O4/c1-27-11-9-14-2-5-17(6-3-14)28-19-7-4-15(22)12-18(19)21(26)24-16-8-10-23-20(25)13-16/h2-8,10,12-13H,9,11H2,1H3,(H2,23,24,25,26)
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n/an/a 1.71E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161340
PNG
(US10087143, Compound 125 | US9051270, 125)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OC2C[C@@H]3C[C@@H]3C2)c1
Show InChI InChI=1S/C19H17F3N2O3/c20-19(21,22)12-1-2-15(18(26)24-13-3-4-23-17(25)9-13)16(8-12)27-14-6-10-5-11(10)7-14/h1-4,8-11,14H,5-7H2,(H2,23,24,25,26)/t10-,11+,14?
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n/an/a 1.75E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161336
PNG
(US10087143, Compound 121 | US9051270, 121)
Show SMILES FC(F)(F)c1ccc(C(=O)Nc2cc[nH]c(=O)c2)c(OCC2CCOC2)c1
Show InChI InChI=1S/C18H17F3N2O4/c19-18(20,21)12-1-2-14(15(7-12)27-10-11-4-6-26-9-11)17(25)23-13-3-5-22-16(24)8-13/h1-3,5,7-8,11H,4,6,9-10H2,(H2,22,23,24,25)
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n/an/a 1.90E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161349
PNG
(US10087143, Compound 140 | US9051270, 134)
Show SMILES CC1(C)CC1COc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N2O3/c1-18(2)9-12(18)10-27-15-4-3-11(19(20,21)22)7-14(15)17(26)24-13-5-6-23-16(25)8-13/h3-8,12H,9-10H2,1-2H3,(H2,23,24,25,26)
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n/an/a 2.10E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%