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Patent code US10087148

Compile Data Set for Download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287966
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- (pyridin-2-yl)-2...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccc[nH]2)c2ccccn2)c2ccccc2n1
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n/an/an/an/a 65n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287980
PNG
(N-(4-(4-((2,2-di(pyridin-4- yl)ethyl)amino)quinazo...)
Show SMILES Cc1cc(NS(C)(=O)=O)ccc1-c1nc(NCC(c2ccncc2)c2ccncc2)c2ccccc2n1
Show InChI InChI=1S/C28H26N6O2S/c1-19-17-22(34-37(2,35)36)7-8-23(19)28-32-26-6-4-3-5-24(26)27(33-28)31-18-25(20-9-13-29-14-10-20)21-11-15-30-16-12-21/h3-17,25,34H,18H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 84n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287952
PNG
(N-(4-(4-((2-phenyl-2-(pyrrolidin-1- yl)ethyl)amino...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(N2CCCC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C27H29N5O2S/c1-35(33,34)31-22-15-13-21(14-16-22)26-29-24-12-6-5-11-23(24)27(30-26)28-19-25(32-17-7-8-18-32)20-9-3-2-4-10-20/h2-6,9-16,25,31H,7-8,17-19H2,1H3,(H,28,29,30)
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n/an/an/an/a 160n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287954
PNG
(2-(4-(dimethylamino)phenyl)-N-(2-(4- methylpiperaz...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(N2CCN(C)CC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C29H34N6/c1-33(2)24-15-13-23(14-16-24)28-31-26-12-8-7-11-25(26)29(32-28)30-21-27(22-9-5-4-6-10-22)35-19-17-34(3)18-20-35/h4-16,27H,17-21H2,1-3H3,(H,30,31,32)
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n/an/an/an/a 30n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287957
PNG
(N-(4-(4-((2-phenyl-2-(pyridin-3- yl)ethyl)amino)qu...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccccc2)c2cccnc2)c2ccccc2n1
Show InChI InChI=1S/C28H25N5O2S/c1-36(34,35)33-23-15-13-21(14-16-23)27-31-26-12-6-5-11-24(26)28(32-27)30-19-25(20-8-3-2-4-9-20)22-10-7-17-29-18-22/h2-18,25,33H,19H2,1H3,(H,30,31,32)
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n/an/an/an/a 25n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287938
PNG
(N-(4-(4-((2-cyclohexyl-2- phenylethyl)amino)quinaz...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(C2CCCCC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C29H32N4O2S/c1-36(34,35)33-24-18-16-23(17-19-24)28-31-27-15-9-8-14-25(27)29(32-28)30-20-26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2,4-5,8-11,14-19,22,26,33H,3,6-7,12-13,20H2,1H3,(H,30,31,32)
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n/an/an/an/a 16n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287948
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(piperi...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(N2CCCCC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C29H33N5/c1-33(2)24-17-15-23(16-18-24)28-31-26-14-8-7-13-25(26)29(32-28)30-21-27(22-11-5-3-6-12-22)34-19-9-4-10-20-34/h3,5-8,11-18,27H,4,9-10,19-21H2,1-2H3,(H,30,31,32)
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n/an/an/an/a 34n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287936
PNG
(N-(4-(4-((2-hydroxy-2,2- diphenylethyl)amino)quina...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(O)(c2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C29H26N4O3S/c1-37(35,36)33-24-18-16-21(17-19-24)27-31-26-15-9-8-14-25(26)28(32-27)30-20-29(34,22-10-4-2-5-11-22)23-12-6-3-7-13-23/h2-19,33-34H,20H2,1H3,(H,30,31,32)
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n/an/an/an/a 11n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287942
PNG
(N-(4-(4-((2-phenyl-2-(pyridin-4- yl)ethyl)amino)qu...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccccc2)c2ccncc2)c2ccccc2n1
Show InChI InChI=1S/C28H25N5O2S/c1-36(34,35)33-23-13-11-22(12-14-23)27-31-26-10-6-5-9-24(26)28(32-27)30-19-25(20-7-3-2-4-8-20)21-15-17-29-18-16-21/h2-18,25,33H,19H2,1H3,(H,30,31,32)
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n/an/an/an/a 4.80n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287949
PNG
(N-(4-(4-((2-phenyl-2-(piperidin-1- yl)ethyl)amino)...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(N2CCCCC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C28H31N5O2S/c1-36(34,35)32-23-16-14-22(15-17-23)27-30-25-13-7-6-12-24(25)28(31-27)29-20-26(21-10-4-2-5-11-21)33-18-8-3-9-19-33/h2,4-7,10-17,26,32H,3,8-9,18-20H2,1H3,(H,29,30,31)
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n/an/an/an/a 62n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287956
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyridi...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccccc2)c2cccnc2)c2ccccc2n1
Show InChI InChI=1S/C29H27N5/c1-34(2)24-16-14-22(15-17-24)28-32-27-13-7-6-12-25(27)29(33-28)31-20-26(21-9-4-3-5-10-21)23-11-8-18-30-19-23/h3-19,26H,20H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 24n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287965
PNG
(N-(4-(4-((2-(pyridin-2-yl)-2-(1H- pyrrol-2-yl)ethy...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccc[nH]2)c2ccccn2)c2ccccc2n1
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n/an/an/an/a 379n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287967
PNG
(N-(2,2-di(pyridin-4-yl)ethyl)-2-(4- (dimethylamino...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccncc2)c2ccncc2)c2ccccc2n1
Show InChI InChI=1S/C28H26N6/c1-34(2)23-9-7-22(8-10-23)27-32-26-6-4-3-5-24(26)28(33-27)31-19-25(20-11-15-29-16-12-20)21-13-17-30-18-14-21/h3-18,25H,19H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 21n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287969
PNG
(2-(4-(dimethylamino)phenyl)-N- phenethylquinazolin...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCCc2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C24H24N4/c1-28(2)20-14-12-19(13-15-20)23-26-22-11-7-6-10-21(22)24(27-23)25-17-16-18-8-4-3-5-9-18/h3-15H,16-17H2,1-2H3,(H,25,26,27)
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n/an/an/an/a 156n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287933
PNG
(N-(2-(6-chloropyridin-2-yl)-2- phenylethyl)-2-(p-t...)
Show SMILES Cc1ccc(cc1)-c1nc(NCC(c2ccccc2)c2cccc(Cl)n2)c2ccccc2n1
Show InChI InChI=1S/C28H23ClN4/c1-19-14-16-21(17-15-19)27-32-24-11-6-5-10-22(24)28(33-27)30-18-23(20-8-3-2-4-9-20)25-12-7-13-26(29)31-25/h2-17,23H,18H2,1H3,(H,30,32,33)
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n/an/an/an/a 380n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287950
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- morpholino-2-phe...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(N2CCOCC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C28H31N5O/c1-32(2)23-14-12-22(13-15-23)27-30-25-11-7-6-10-24(25)28(31-27)29-20-26(21-8-4-3-5-9-21)33-16-18-34-19-17-33/h3-15,26H,16-20H2,1-2H3,(H,29,30,31)
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n/an/an/an/a 15n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287959
PNG
(N-(4-(4-((2,3- diphenylpropyl)amino)quinazolin-2- ...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(Cc2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C30H28N4O2S/c1-37(35,36)34-26-18-16-24(17-19-26)29-32-28-15-9-8-14-27(28)30(33-29)31-21-25(23-12-6-3-7-13-23)20-22-10-4-2-5-11-22/h2-19,25,34H,20-21H2,1H3,(H,31,32,33)
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n/an/an/an/a 58n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287960
PNG
((5-(2-((2-(4-(dimethylamino)-2- methylphenyl)quina...)
Show SMILES CN(C)c1ccc(c(C)c1)-c1nc(NCC(c2ccc(CO)[nH]2)c2ccccc2)c2ccccc2n1
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n/an/an/an/a 18n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287964
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- (pyridin-3-yl)-2...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccc[nH]2)c2cccnc2)c2ccccc2n1
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n/an/an/an/a 47n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287974
PNG
(N-(4-(4-((1,2- diphenylethyl)amino)quinazolin-2- y...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NC(Cc2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C29H26N4O2S/c1-36(34,35)33-24-18-16-23(17-19-24)28-30-26-15-9-8-14-25(26)29(32-28)31-27(22-12-6-3-7-13-22)20-21-10-4-2-5-11-21/h2-19,27,33H,20H2,1H3,(H,30,31,32)
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n/an/an/an/a 50n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287977
PNG
(2-(4-(dimethylamino)phenyl)-N-(3- methyl-2-phenylb...)
Show SMILES CC(C)C(CNc1nc(nc2ccccc12)-c1ccc(cc1)N(C)C)c1ccccc1
Show InChI InChI=1S/C27H30N4/c1-19(2)24(20-10-6-5-7-11-20)18-28-27-23-12-8-9-13-25(23)29-26(30-27)21-14-16-22(17-15-21)31(3)4/h5-17,19,24H,18H2,1-4H3,(H,28,29,30)
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n/an/an/an/a 30n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287979
PNG
((1R,2S)-2-(((2-(4- (dimethylamino)phenyl)quinazoli...)
Show SMILES CCN(CC)C(=O)[C@@]1(C[C@@H]1CNc1nc(nc2ccccc12)-c1ccc(cc1)N(C)C)c1ccccc1
Show InChI InChI=1S/C31H35N5O/c1-5-36(6-2)30(37)31(23-12-8-7-9-13-23)20-24(31)21-32-29-26-14-10-11-15-27(26)33-28(34-29)22-16-18-25(19-17-22)35(3)4/h7-19,24H,5-6,20-21H2,1-4H3,(H,32,33,34)/t24-,31+/m1/s1
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n/an/an/an/a 243n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287939
PNG
(N-(2-cyclohexyl-2-phenylethyl)-2-(4- (dimethylamin...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(C2CCCCC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C30H34N4/c1-34(2)25-19-17-24(18-20-25)29-32-28-16-10-9-15-26(28)30(33-29)31-21-27(22-11-5-3-6-12-22)23-13-7-4-8-14-23/h3,5-6,9-12,15-20,23,27H,4,7-8,13-14,21H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 46n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287943
PNG
(2-(4-dimethylamino)phenyl)-N-(2- phenyl-2-(pyridin...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccccc2)c2ccncc2)c2ccccc2n1
Show InChI InChI=1S/C29H27N5/c1-34(2)24-14-12-23(13-15-24)28-32-27-11-7-6-10-25(27)29(33-28)31-20-26(21-8-4-3-5-9-21)22-16-18-30-19-17-22/h3-19,26H,20H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 13n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287944
PNG
(N-(4-(4-((2-(1H-imidazol-1-yl)-2- phenylethyl)amin...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccccc2)n2ccnc2)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2S/c1-35(33,34)31-21-13-11-20(12-14-21)25-29-23-10-6-5-9-22(23)26(30-25)28-17-24(32-16-15-27-18-32)19-7-3-2-4-8-19/h2-16,18,24,31H,17H2,1H3,(H,28,29,30)
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n/an/an/an/a 100n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287953
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyrrol...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(N2CCCC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C28H31N5/c1-32(2)23-16-14-22(15-17-23)27-30-25-13-7-6-12-24(25)28(31-27)29-20-26(33-18-8-9-19-33)21-10-4-3-5-11-21/h3-7,10-17,26H,8-9,18-20H2,1-2H3,(H,29,30,31)
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n/an/an/an/a 112n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287962
PNG
(N-(4-(4-((2-(pyridin-3-yl)-2-(1H- pyrrol-2-yl)ethy...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccc[nH]2)c2cccnc2)c2ccccc2n1
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n/an/an/an/a 202n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287970
PNG
(N-(4-(4-(phenethylamino)quinazolin-2- yl)phenyl)me...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCCc2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C23H22N4O2S/c1-30(28,29)27-19-13-11-18(12-14-19)22-25-21-10-6-5-9-20(21)23(26-22)24-16-15-17-7-3-2-4-8-17/h2-14,27H,15-16H2,1H3,(H,24,25,26)
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n/an/an/an/a 159n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287972
PNG
(N-(4-(4-((2,2- diphenylpropyl)amino)quinazolin-2- ...)
Show SMILES CC(CNc1nc(nc2ccccc12)-c1ccc(NS(C)(=O)=O)cc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H28N4O2S/c1-30(23-11-5-3-6-12-23,24-13-7-4-8-14-24)21-31-29-26-15-9-10-16-27(26)32-28(33-29)22-17-19-25(20-18-22)34-37(2,35)36/h3-20,34H,21H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 16n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287975
PNG
(N-(4-(4-((1,3- diphenylpropyl)amino)quinazolin-2- ...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NC(CCc2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C30H28N4O2S/c1-37(35,36)34-25-19-17-24(18-20-25)29-32-28-15-9-8-14-26(28)30(33-29)31-27(23-12-6-3-7-13-23)21-16-22-10-4-2-5-11-22/h2-15,17-20,27,34H,16,21H2,1H3,(H,31,32,33)
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n/an/an/an/a 71n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287981
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- phenoxy-2-phenyl...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(Oc2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C30H28N4O/c1-34(2)24-19-17-23(18-20-24)29-32-27-16-10-9-15-26(27)30(33-29)31-21-28(22-11-5-3-6-12-22)35-25-13-7-4-8-14-25/h3-20,28H,21H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 42n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287934
PNG
(N-(4-(4-((2-phenyl-2-(pyridin-2- yl)ethyl)amino)qu...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccccc2)c2ccccn2)c2ccccc2n1
Show InChI InChI=1S/C28H25N5O2S/c1-36(34,35)33-22-16-14-21(15-17-22)27-31-26-13-6-5-11-23(26)28(32-27)30-19-24(20-9-3-2-4-10-20)25-12-7-8-18-29-25/h2-18,24,33H,19H2,1H3,(H,30,31,32)
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n/an/an/an/a 50n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287935
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyridi...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccccc2)c2ccccn2)c2ccccc2n1
Show InChI InChI=1S/C29H27N5/c1-34(2)23-17-15-22(16-18-23)28-32-27-14-7-6-12-24(27)29(33-28)31-20-25(21-10-4-3-5-11-21)26-13-8-9-19-30-26/h3-19,25H,20H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 22n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287937
PNG
(2-((2-(4- (dimethylamino)phenyl)quinazolin-4- yl)a...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(O)(c2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C30H28N4O/c1-34(2)25-19-17-22(18-20-25)28-32-27-16-10-9-15-26(27)29(33-28)31-21-30(35,23-11-5-3-6-12-23)24-13-7-4-8-14-24/h3-20,35H,21H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 6.70n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287940
PNG
(N-(4-(4-((2-phenyl-2-(pyrimidin-2- yl)ethyl)amino)...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccccc2)c2ncccn2)c2ccccc2n1
Show InChI InChI=1S/C27H24N6O2S/c1-36(34,35)33-21-14-12-20(13-15-21)25-31-24-11-6-5-10-22(24)27(32-25)30-18-23(19-8-3-2-4-9-19)26-28-16-7-17-29-26/h2-17,23,33H,18H2,1H3,(H,30,31,32)
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n/an/an/an/a 477n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287946
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(1H-pyr...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccc[nH]2)c2ccccc2)c2ccccc2n1
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n/an/an/an/a 5.60n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287951
PNG
(N-(4-(4-((2-morpholino-2- phenylethyl)amino)quinaz...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(N2CCOCC2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C27H29N5O3S/c1-36(33,34)31-22-13-11-21(12-14-22)26-29-24-10-6-5-9-23(24)27(30-26)28-19-25(20-7-3-2-4-8-20)32-15-17-35-18-16-32/h2-14,25,31H,15-19H2,1H3,(H,28,29,30)
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n/an/an/an/a 43n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287955
PNG
(N-(4-(4-((2-(4-methylpiperazin-1-yl)-2- phenylethy...)
Show SMILES CN1CCN(CC1)C(CNc1nc(nc2ccccc12)-c1ccc(NS(C)(=O)=O)cc1)c1ccccc1
Show InChI InChI=1S/C28H32N6O2S/c1-33-16-18-34(19-17-33)26(21-8-4-3-5-9-21)20-29-28-24-10-6-7-11-25(24)30-27(31-28)22-12-14-23(15-13-22)32-37(2,35)36/h3-15,26,32H,16-20H2,1-2H3,(H,29,30,31)
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n/an/an/an/a 62n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287958
PNG
(2-(4-(dimethylamino)phenyl)-N-(2,3- diphenylpropyl...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(Cc2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C31H30N4/c1-35(2)27-19-17-25(18-20-27)30-33-29-16-10-9-15-28(29)31(34-30)32-22-26(24-13-7-4-8-14-24)21-23-11-5-3-6-12-23/h3-20,26H,21-22H2,1-2H3,(H,32,33,34)
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n/an/an/an/a 39n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287973
PNG
(2-(4-(dimethylamino)phenyl)-N-(1,2- diphenylethyl)...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NC(Cc2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C30H28N4/c1-34(2)25-19-17-24(18-20-25)29-31-27-16-10-9-15-26(27)30(33-29)32-28(23-13-7-4-8-14-23)21-22-11-5-3-6-12-22/h3-20,28H,21H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 40n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287976
PNG
(2-(4-(dimethylamino)phenyl)-N-(1,3- diphenylpropyl...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NC(CCc2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C31H30N4/c1-35(2)26-20-18-25(19-21-26)30-33-29-16-10-9-15-27(29)31(34-30)32-28(24-13-7-4-8-14-24)22-17-23-11-5-3-6-12-23/h3-16,18-21,28H,17,22H2,1-2H3,(H,32,33,34)
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n/an/an/an/a 75n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287982
PNG
(N-(4-(4-((2-phenoxy-2- phenylethyl)amino)quinazoli...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(Oc2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C29H26N4O3S/c1-37(34,35)33-23-18-16-22(17-19-23)28-31-26-15-9-8-14-25(26)29(32-28)30-20-27(21-10-4-2-5-11-21)36-24-12-6-3-7-13-24/h2-19,27,33H,20H2,1H3,(H,30,31,32)
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n/an/an/an/a 30n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287945
PNG
(N-(2-(1H-imidazol-1-yl)-2- phenylethyl)-2-(4- (dim...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccccc2)n2ccnc2)c2ccccc2n1
Show InChI InChI=1S/C27H26N6/c1-32(2)22-14-12-21(13-15-22)26-30-24-11-7-6-10-23(24)27(31-26)29-18-25(33-17-16-28-19-33)20-8-4-3-5-9-20/h3-17,19,25H,18H2,1-2H3,(H,29,30,31)
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n/an/an/an/a 138n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287947
PNG
(N-(4-(4-((2-phenyl-2-(1H-pyrrol-2- yl)ethyl)amino)...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccc[nH]2)c2ccccc2)c2ccccc2n1
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n/an/an/an/a 43n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287961
PNG
(N-(3-methyl-4-(4-((2-phenyl-2- (pyridin-4-yl)ethyl...)
Show SMILES Cc1cc(NS(C)(=O)=O)ccc1-c1nc(NCC(c2ccccc2)c2ccncc2)c2ccccc2n1
Show InChI InChI=1S/C29H27N5O2S/c1-20-18-23(34-37(2,35)36)12-13-24(20)29-32-27-11-7-6-10-25(27)28(33-29)31-19-26(21-8-4-3-5-9-21)22-14-16-30-17-15-22/h3-18,26,34H,19H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 7.40n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287968
PNG
(N-(4-(4-((2,2-di(pyridin-4- yl)ethyl)amino)quinazo...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1nc(NCC(c2ccncc2)c2ccncc2)c2ccccc2n1
Show InChI InChI=1S/C27H24N6O2S/c1-36(34,35)33-22-8-6-21(7-9-22)26-31-25-5-3-2-4-23(25)27(32-26)30-18-24(19-10-14-28-15-11-19)20-12-16-29-17-13-20/h2-17,24,33H,18H2,1H3,(H,30,31,32)
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n/an/an/an/a 47n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287971
PNG
(2-(4-(dimethylamino)phenyl)-N-(2,2- diphenylpropyl...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(C)(c2ccccc2)c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C31H30N4/c1-31(24-12-6-4-7-13-24,25-14-8-5-9-15-25)22-32-30-27-16-10-11-17-28(27)33-29(34-30)23-18-20-26(21-19-23)35(2)3/h4-21H,22H2,1-3H3,(H,32,33,34)
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n/an/an/an/a 15n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287978
PNG
(N-(4-(4-((3-methyl-2- phenylbutyl)amino)quinazolin...)
Show SMILES CC(C)C(CNc1nc(nc2ccccc12)-c1ccc(NS(C)(=O)=O)cc1)c1ccccc1
Show InChI InChI=1S/C26H28N4O2S/c1-18(2)23(19-9-5-4-6-10-19)17-27-26-22-11-7-8-12-24(22)28-25(29-26)20-13-15-21(16-14-20)30-33(3,31)32/h4-16,18,23,30H,17H2,1-3H3,(H,27,28,29)
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n/an/an/an/a 20n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM287941
PNG
(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyrimi...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(NCC(c2ccccc2)c2ncccn2)c2ccccc2n1
Show InChI InChI=1S/C28H26N6/c1-34(2)22-15-13-21(14-16-22)26-32-25-12-7-6-11-23(25)28(33-26)31-19-24(20-9-4-3-5-10-20)27-29-17-8-18-30-27/h3-18,24H,19H2,1-2H3,(H,31,32,33)
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n/an/an/an/a 117n/an/an/an/a



THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTE OF HEALTH; SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...


US Patent US10087148 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%