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Patent code US10087185

Compile Data Set for Download or QSAR
Found 125 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288255
PNG
(7-Chloro-5-(2-isopropyl-6-(trifluoromethyl)pyrazol...)
Show SMILES CC(C)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288248
PNG
(5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...)
Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C17H8ClF6N3O/c18-11-4-8(3-7-5-13(28)25-14(7)11)15-10(16(19,20)21)2-1-9-6-12(17(22,23)24)26-27(9)15/h1-4,6H,5H2,(H,25,28)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0130n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288254
PNG
(5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...)
Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N3O/c1-9(2)15-8-12-3-4-13(19(21,22)23)18(26(12)25-15)11-5-10-7-16(27)24-17(10)14(20)6-11/h3-6,8-9H,7H2,1-2H3,(H,24,27)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0130n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288245
PNG
(5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...)
Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288302
PNG
(7-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...)
Show SMILES FC(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288247
PNG
(5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H11F6N3O/c1-8-4-10(5-9-6-14(28)25-15(8)9)16-12(17(19,20)21)3-2-11-7-13(18(22,23)24)26-27(11)16/h2-5,7H,6H2,1H3,(H,25,28)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288253
PNG
(5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...)
Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(C)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N3O/c1-10(2)16-9-14-4-5-15(20(21,22)23)19(26(14)25-16)13-6-11(3)18-12(7-13)8-17(27)24-18/h4-7,9-10H,8H2,1-3H3,(H,24,27)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288246
PNG
(5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288250
PNG
(5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...)
Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1
Show InChI InChI=1S/C19H13ClF3N3O/c20-14-6-11(5-10-7-16(27)24-17(10)14)18-13(19(21,22)23)4-3-12-8-15(9-1-2-9)25-26(12)18/h3-6,8-9H,1-2,7H2,(H,24,27)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288303
PNG
(6-(Difluoromethyl)-7-(7-methyl-1H-indazol-5-yl)-2-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0250n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288237
PNG
(6-(4-Fluorophenyl)-5-(7-methyl-1H-indazol-5-yl)-2-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1
GoogleScholar
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UniChem
n/an/a 0.0400n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288304
PNG
(5-[6-(Difluoromethyl)-4-methyl-2-(trifluoromethyl)...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2cc(nn12)C(F)(F)F)C(F)F
Show InChI InChI=1S/C19H14F5N3O/c1-8-4-12(18(20)21)17(27-13(8)7-14(26-27)19(22,23)24)11-3-9(2)16-10(5-11)6-15(28)25-16/h3-5,7,18H,6H2,1-2H3,(H,25,28)
GoogleScholar
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UniChem
n/an/a 0.0500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288249
PNG
(5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N3O/c1-10-6-13(7-12-8-17(27)24-18(10)12)19-15(20(21,22)23)5-4-14-9-16(11-2-3-11)25-26(14)19/h4-7,9,11H,2-3,8H2,1H3,(H,24,27)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288235
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-(1,1-difluoroethyl)...)
Show SMILES CC(F)(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288301
PNG
(5-[6-(Difluoromethyl)-2-(trifluoromethyl)pyrazolo[...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F
Show InChI InChI=1S/C18H12F5N3O/c1-8-4-10(5-9-6-14(27)24-15(8)9)16-12(17(19)20)3-2-11-7-13(18(21,22)23)25-26(11)16/h2-5,7,17H,6H2,1H3,(H,24,27)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288251
PNG
(5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0500n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288189
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-6-...)
Show SMILES FC(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0630n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288252
PNG
(7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyraz...)
Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0630n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288252
PNG
(7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyraz...)
Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0630n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288239
PNG
(5-(6-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]t...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C22H14F4N4O/c1-11-8-14(9-13-10-18(31)28-19(11)13)20-16(12-2-4-15(23)5-3-12)6-7-17-27-21(22(24,25)26)29-30(17)20/h2-9H,10H2,1H3,(H,28,31)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0630n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288218
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-6-(triflu...)
Show SMILES CC(C)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0790n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288183
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2,6-bis(trifluorometh...)
Show SMILES FC(F)(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0790n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288256
PNG
(5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...)
Show SMILES CC(C)c1cc2ccc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0790n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288294
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difl...)
Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1
GoogleScholar
AffyNet 
UniChem
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288307
PNG
(7-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-4-...)
Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(cc12)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288224
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-(1,1-difluoroethyl)...)
Show SMILES CC(F)(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288198
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...)
Show SMILES FC(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288305
PNG
(6-(Difluoromethyl)-4-methyl-7-(7-methyl-1H-indazol...)
Show SMILES Cc1cc(C(F)F)c(-c2cc(C)c3[nH]ncc3c2)n2nc(cc12)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288260
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-8-...)
Show SMILES Cc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)F)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288244
PNG
(2-Cyclopropyl-6-(4-fluorophenyl)-5-(7-methyl-1H-in...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C1CC1)-c1ccc(F)cc1
GoogleScholar
AffyNet 
UniChem
n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288257
PNG
(7-Chloro-5-(2-cyclopropyl-8-methyl-6-(trifluoromet...)
Show SMILES Cc1cc(c(-c2cc3CC(=O)Nc3c(Cl)c2)n2nc(nc12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C19H14ClF3N4O/c1-8-4-12(19(21,22)23)16(27-18(8)25-17(26-27)9-2-3-9)11-5-10-7-14(28)24-15(10)13(20)6-11/h4-6,9H,2-3,7H2,1H3,(H,24,28)
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n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288220
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(trif...)
Show SMILES FC(F)(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
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n/an/a 0.126n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288193
PNG
(2-(Difluoromethyl)-6-(trifluoromethyl)-5-(7-(trifl...)
Show SMILES FC(F)c1nc2ccc(c(-c3cc(c4[nH]ncc4c3)C(F)(F)F)n2n1)C(F)(F)F
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288199
PNG
(6-(Difluoromethyl)-5-(7-methyl-1H-indazol-5-yl)-2-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)C(F)F
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288275
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difl...)
Show SMILES CCc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288285
PNG
(7-Chloro-5-(2-ethyl-8-methyl-6-(trifluoromethyl)- ...)
Show SMILES Cc1cc(c(-c2cc3CC(=O)Nc3c(Cl)c2)n2nc(nc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H9ClF6N4O/c1-6-2-9(16(19,20)21)13(28-14(6)26-15(27-28)17(22,23)24)8-3-7-5-11(29)25-12(7)10(18)4-8/h2-4H,5H2,1H3,(H,25,29)
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288262
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-8-ethyl...)
Show SMILES CCc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1)C(F)(F)F
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288258
PNG
(2-Cyclopropyl-8-methyl-5-(7-methyl-1H-indazol-5-yl...)
Show SMILES Cc1cc(c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C1CC1)C(F)(F)F
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UniChem
n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288286
PNG
(7-Ethyl-5-(8-methyl-2,6-bis(trifluoromethyl)-[1,2,...)
Show SMILES CCc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2nc(nn12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H14F6N4O/c1-3-9-5-11(6-10-7-13(30)26-14(9)10)15-12(18(20,21)22)4-8(2)16-27-17(19(23,24)25)28-29(15)16/h4-6H,3,7H2,1-2H3,(H,26,30)
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n/an/a 0.158n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288230
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difl...)
Show SMILES FC(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288265
PNG
(5-(7-Chloro-1H-indazol-5-yl)-8-methyl-2-propyl-6- ...)
Show SMILES CCCc1nc2c(C)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288215
PNG
(2-Cyclopropyl-8-fluoro-5-(7-methyl-1H-indazol-5-yl...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(cc(F)c2nc(nn12)C1CC1)C(F)(F)F
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288188
PNG
(5-(7-Chloro-1H-indazol-5-yl)-8-methyl-2,6-bis(trif...)
Show SMILES Cc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F)C(F)(F)F
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288184
PNG
(5-(7-Methyl-1H-indazol-5-yl)-2,6-bis(trifluorometh...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)C(F)(F)F
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288243
PNG
(2-Ethyl-6-(4-fluorophenyl)-5-(7-methyl-1H-indazol-...)
Show SMILES CCc1nc2ccc(-c3ccc(F)cc3)c(-c3cc(C)c4[nH]ncc4c3)n2n1
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288259
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-8-...)
Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288281
PNG
(5-(2-Cyclopropyl-8-methyl-6-(trifluoromethyl)- | U...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2nc(nn12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C20H17F3N4O/c1-9-5-13(7-12-8-15(28)24-16(9)12)17-14(20(21,22)23)6-10(2)19-25-18(11-3-4-11)26-27(17)19/h5-7,11H,3-4,8H2,1-2H3,(H,24,28)
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288185
PNG
(5-(2,6-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES FC(F)(F)c1nc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C16H7ClF6N4O/c17-9-4-7(3-6-5-11(28)25-12(6)9)13-8(15(18,19)20)1-2-10-24-14(16(21,22)23)26-27(10)13/h1-4H,5H2,(H,25,28)
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288200
PNG
(7-Chloro-5-(6-(difluoromethyl)-2-(trifluoromethyl)...)
Show SMILES FC(F)c1ccc2nc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C16H8ClF5N4O/c17-9-4-7(3-6-5-11(27)24-12(6)9)13-8(14(18)19)1-2-10-23-15(16(20,21)22)25-26(10)13/h1-4,14H,5H2,(H,24,27)
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288259
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-8-...)
Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288306
PNG
(7-Chloro-5-[6-(difluoromethyl)-4-methyl-2- | US100...)
Show SMILES Cc1cc(C(F)F)c(-c2cc3CC(=O)Nc3c(Cl)c2)n2nc(cc12)C(F)(F)F
Show InChI InChI=1S/C18H11ClF5N3O/c1-7-2-10(17(20)21)16(27-12(7)6-13(26-27)18(22,23)24)9-3-8-5-14(28)25-15(8)11(19)4-9/h2-4,6,17H,5H2,1H3,(H,25,28)
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n/an/a 0.251n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288216
PNG
(5-(7-Chloro-1H-indazol-5-yl)-8-fluoro-2-isopropyl-...)
Show SMILES CC(C)c1nc2c(F)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288221
PNG
(2-Cyclopropyl-5-(7-methyl-1H-indazol-5-yl)-6-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C1CC1)C(F)(F)F
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288287
PNG
(7-Methyl-5-(8-methyl-2,6-bis(trifluoromethyl)- | U...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2nc(nn12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H12F6N4O/c1-7-3-10(5-9-6-12(29)25-13(7)9)14-11(17(19,20)21)4-8(2)15-26-16(18(22,23)24)27-28(14)15/h3-5H,6H2,1-2H3,(H,25,29)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288295
PNG
(7-Chloro-5-(2-cyclopropyl-6-(difluoromethyl)-8-met...)
Show SMILES Cc1cc(C(F)F)c(-c2cc3CC(=O)Nc3c(Cl)c2)n2nc(nc12)C1CC1
Show InChI InChI=1S/C19H15ClF2N4O/c1-8-4-12(17(21)22)16(26-19(8)24-18(25-26)9-2-3-9)11-5-10-7-14(27)23-15(10)13(20)6-11/h4-6,9,17H,2-3,7H2,1H3,(H,23,27)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288283
PNG
(2-Ethyl-8-methyl-6-(trifluoromethyl)-5-(7-(trifluo...)
Show SMILES CCc1nc2c(C)cc(c(-c3cc(c4[nH]ncc4c3)C(F)(F)F)n2n1)C(F)(F)F
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288267
PNG
(7-Methyl-5-(8-methyl-2-propyl-6-(trifluoromethyl)-...)
Show SMILES CCCc1nc2c(C)cc(c(-c3cc4CC(=O)Nc4c(C)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O/c1-4-5-15-24-19-11(3)7-14(20(21,22)23)18(27(19)26-15)13-6-10(2)17-12(8-13)9-16(28)25-17/h6-8H,4-5,9H2,1-3H3,(H,25,28)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288264
PNG
(5-(2-Cyclopropyl-8-ethyl-6-(trifluoromethyl)- | US...)
Show SMILES CCc1cc(c(-c2cc3CC(=O)Nc3c(C)c2)n2nc(nc12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O/c1-3-11-8-15(21(22,23)24)18(28-20(11)26-19(27-28)12-4-5-12)14-6-10(2)17-13(7-14)9-16(29)25-17/h6-8,12H,3-5,9H2,1-2H3,(H,25,29)
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288187
PNG
(8-Chloro-5-(7-chloro-1H-indazol-5-yl)-2,6-bis(trif...)
Show SMILES FC(F)(F)c1nc2c(Cl)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288219
PNG
(2-Isopropyl-5-(7-methyl-1H-indazol-5-yl)-6-(triflu...)
Show SMILES CC(C)c1nc2ccc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F
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n/an/a 0.316n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288211
PNG
(8-Chloro-5-(7-chloro-1H-indazol-5-yl)-2-ethyl-6-(t...)
Show SMILES CCc1nc2c(Cl)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
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UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288191
PNG
(7-Chloro-5-(2-(difluoromethyl)-6-(trifluoromethyl)...)
Show SMILES FC(F)c1nc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C16H8ClF5N4O/c17-9-4-7(3-6-5-11(27)24-12(6)9)13-8(16(20,21)22)1-2-10-23-15(14(18)19)25-26(10)13/h1-4,14H,5H2,(H,24,27)
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n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288261
PNG
(2-(Difluoromethyl)-8-methyl-5-(7-methyl-1H-indazol...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(cc(C)c2nc(nn12)C(F)F)C(F)(F)F
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n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288207
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-ethyl-6-(trifluorom...)
Show SMILES CCc1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288296
PNG
(2-Cyclopropyl-6-(difluoromethyl)-8-methyl-5-(7-met...)
Show SMILES Cc1cc(C(F)F)c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C1CC1
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UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288278
PNG
(8-Chloro-5-(7-chloro-1H-indazol-5-yl)-2-propyl-6- ...)
Show SMILES CCCc1nc2c(Cl)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
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UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288222
PNG
(7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)-[1,2...)
Show SMILES FC(F)(F)c1ccc2nc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1
Show InChI InChI=1S/C18H12ClF3N4O/c19-12-6-10(5-9-7-14(27)24-15(9)12)16-11(18(20,21)22)3-4-13-23-17(8-1-2-8)25-26(13)16/h3-6,8H,1-2,7H2,(H,24,27)
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UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288226
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...)
Show SMILES CCc1nc2ccc(C(F)F)c(-c3cc(Cl)c4[nH]ncc4c3)n2n1
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UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288269
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-8-...)
Show SMILES CCc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)F)C(F)(F)F
GoogleScholar
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UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288217
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-ethyl-8-methyl-6-(t...)
Show SMILES CCc1nc2c(C)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288276
PNG
(2-Cyclopropyl-6-(difluoromethyl)-8-ethyl-5-(7-meth...)
Show SMILES CCc1cc(C(F)F)c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C1CC1
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UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288190
PNG
(5-(7-Methyl-1H-indazol-5-yl)-2-(difluoromethyl)-6-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)F)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288261
PNG
(2-(Difluoromethyl)-8-methyl-5-(7-methyl-1H-indazol...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(cc(C)c2nc(nn12)C(F)F)C(F)(F)F
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UniChem
n/an/a 0.398n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288273
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-8-...)
Show SMILES CCc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F
GoogleScholar
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UniChem
n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288289
PNG
(8-Methyl-5-(7-methyl-1H-indazol-5-yl)-2,6-bis(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(cc(C)c2nc(nn12)C(F)(F)F)C(F)(F)F
GoogleScholar
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UniChem
n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288263
PNG
(2-Cyclopropyl-8-ethyl-5-(7-methyl-1H-indazol-5-yl)...)
Show SMILES CCc1cc(c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C1CC1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288234
PNG
(6-Ethyl-5-(7-methyl-1H-indazol-5-yl)-2-(trifluorom...)
Show SMILES CCc1ccc2nc(nn2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288279
PNG
(7-Chloro-5-(8-chloro-2-propyl-6-(trifluoromethyl)-...)
Show SMILES CCCc1nc2c(Cl)cc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C18H13Cl2F3N4O/c1-2-3-13-24-17-12(20)7-10(18(21,22)23)16(27(17)26-13)9-4-8-6-14(28)25-15(8)11(19)5-9/h4-5,7H,2-3,6H2,1H3,(H,25,28)
GoogleScholar
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UniChem
n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288186
PNG
(5-(2,6-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H10F6N4O/c1-7-4-9(5-8-6-12(28)25-13(7)8)14-10(16(18,19)20)2-3-11-24-15(17(21,22)23)26-27(11)14/h2-5H,6H2,1H3,(H,25,28)
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UniChem
n/an/a 0.501n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288282
PNG
(7-Chloro-5-(2-ethyl-8-methyl-6-(trifluoromethyl)- ...)
Show SMILES CCc1nc2c(C)cc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N4O/c1-3-13-23-17-8(2)4-11(18(20,21)22)16(26(17)25-13)10-5-9-7-14(27)24-15(9)12(19)6-10/h4-6H,3,7H2,1-2H3,(H,24,27)
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UniChem
n/an/a 0.631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288201
PNG
(5-[6-(Difluoromethyl)-2-(trifluoromethyl)-[1,2,4]t...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)C(F)F
Show InChI InChI=1S/C17H11F5N4O/c1-7-4-9(5-8-6-12(27)24-13(7)8)14-10(15(18)19)2-3-11-23-16(17(20,21)22)25-26(11)14/h2-5,15H,6H2,1H3,(H,24,27)
GoogleScholar
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UniChem
n/an/a 0.631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288223
PNG
(5-(2-Cyclopropyl-6-(trifluoromethyl)-[1,2,4]triazo...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C1CC1)C(F)(F)F
Show InChI InChI=1S/C19H15F3N4O/c1-9-6-12(7-11-8-15(27)24-16(9)11)17-13(19(20,21)22)4-5-14-23-18(10-2-3-10)25-26(14)17/h4-7,10H,2-3,8H2,1H3,(H,24,27)
GoogleScholar
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UniChem
n/an/a 0.631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288203
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-methyl-6-(trifluoro...)
Show SMILES Cc1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.631n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288240
PNG
(5-(7-Methyl-1H-indazol-5-yl)-6-(pyridin-3-yl)-2-(t...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1cccnc1
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n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288231
PNG
(2-Cyclopropyl-6-(difluoromethyl)-5-(7-methyl-1H-in...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C1CC1)C(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288292
PNG
(7-Chloro-5-(6-(difluoromethyl)-8-methyl-2-(trifluo...)
Show SMILES Cc1cc(C(F)F)c(-c2cc3CC(=O)Nc3c(Cl)c2)n2nc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H10ClF5N4O/c1-6-2-9(14(19)20)13(27-15(6)25-16(26-27)17(21,22)23)8-3-7-5-11(28)24-12(7)10(18)4-8/h2-4,14H,5H2,1H3,(H,24,28)
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AffyNet 
UniChem
n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288236
PNG
(6-(2-(Difluoromethyl)-6-(trifluoromethyl)-[1,2,4]t...)
Show SMILES FC(F)c1nc2ccc(c(-c3ccc4[nH]c(=O)sc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288271
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2,8-diethyl-6-(triflu...)
Show SMILES CCc1nc2c(CC)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288293
PNG
(6-(Difluoromethyl)-8-methyl-5-(7-methyl-1H-indazol...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(cc(C)c2nc(nn12)C(F)(F)F)C(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288280
PNG
(5-(8-Chloro-2-propyl-6-(trifluoromethyl)-[1,2,4]tr...)
Show SMILES CCCc1nc2c(Cl)cc(c(-c3cc4CC(=O)Nc4c(C)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C19H16ClF3N4O/c1-3-4-14-24-18-13(20)8-12(19(21,22)23)17(27(18)26-14)11-5-9(2)16-10(6-11)7-15(28)25-16/h5-6,8H,3-4,7H2,1-2H3,(H,25,28)
GoogleScholar
AffyNet 
UniChem
n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288192
PNG
(7-Methyl-5-(2-(difluoromethyl)-6-(trifluoromethyl)...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)F)C(F)(F)F
Show InChI InChI=1S/C17H11F5N4O/c1-7-4-9(5-8-6-12(27)24-13(7)8)14-10(17(20,21)22)2-3-11-23-16(15(18)19)25-26(11)14/h2-5,15H,6H2,1H3,(H,24,27)
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UniChem
n/an/a 0.794n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288232
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-methoxy-2-(trifluor...)
Show SMILES COc1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
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n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288274
PNG
(6-(Difluoromethyl)-8-ethyl-5-(7-methyl-1H-indazol-...)
Show SMILES CCc1cc(C(F)F)c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F
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n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288208
PNG
(2-Ethyl-5-(7-methyl-1H-indazol-5-yl)-6-(trifluorom...)
Show SMILES CCc1nc2ccc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F
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n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288266
PNG
(8-Methyl-5-(7-methyl-1H-indazol-5-yl)-2-propyl-6- ...)
Show SMILES CCCc1nc2c(C)cc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F
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n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288242
PNG
(6-(4-Fluorophenyl)-2-methyl-5-(7-methyl-1H-indazol...)
Show SMILES Cc1nc2ccc(-c3ccc(F)cc3)c(-c3cc(C)c4[nH]ncc4c3)n2n1
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n/an/a 1.26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288227
PNG
(6-(Difluoromethyl)-2-ethyl-5-(7-methyl-1H-indazol-...)
Show SMILES CCc1nc2ccc(C(F)F)c(-c3cc(C)c4[nH]ncc4c3)n2n1
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UniChem
n/an/a 1.26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288209
PNG
(7-Chloro-5-(2-ethyl-6-(trifluoromethyl)-[1,2,4]tri...)
Show SMILES CCc1nc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C17H12ClF3N4O/c1-2-12-22-13-4-3-10(17(19,20)21)16(25(13)24-12)9-5-8-7-14(26)23-15(8)11(18)6-9/h3-6H,2,7H2,1H3,(H,23,26)
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n/an/a 1.26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288238
PNG
(6-(4-Fluorophenyl)-5-(1H-indazol-5-yl)-2-(trifluor...)
Show SMILES Fc1ccc(cc1)-c1ccc2nc(nn2c1-c1ccc2[nH]ncc2c1)C(F)(F)F
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UniChem
n/an/a 1.26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288288
PNG
(7-Methoxy-5-(8-methyl-2,6-bis(trifluoromethyl)-[1,...)
Show SMILES COc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2nc(nn12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H12F6N4O2/c1-7-3-10(17(19,20)21)14(28-15(7)26-16(27-28)18(22,23)24)9-4-8-6-12(29)25-13(8)11(5-9)30-2/h3-5H,6H2,1-2H3,(H,25,29)
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n/an/a 1.26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288213
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-ethyl-8-fluoro-6-(t...)
Show SMILES CCc1nc2c(F)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
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UniChem
n/an/a 1.26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288284
PNG
(5-(2-Ethyl-8-methyl-6-(trifluoromethyl)-[1,2,4]tri...)
Show SMILES CCc1nc2c(C)cc(c(-c3cc4CC(=O)Nc4c(c3)C(F)(F)F)n2n1)C(F)(F)F
Show InChI InChI=1S/C19H14F6N4O/c1-3-13-26-17-8(2)4-12(19(23,24)25)16(29(17)28-13)10-5-9-7-14(30)27-15(9)11(6-10)18(20,21)22/h4-6H,3,7H2,1-2H3,(H,27,30)
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n/an/a 1.58n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288270
PNG
(2-(Difluoromethyl)-8-ethyl-5-(7-methyl-1H-indazol-...)
Show SMILES CCc1cc(c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C(F)F)C(F)(F)F
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n/an/a 1.58n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288197
PNG
(2-(Difluoromethyl)-6-methoxy-5-(7-(trifluoromethyl...)
Show SMILES COc1ccc2nc(nn2c1-c1cc(c2[nH]ncc2c1)C(F)(F)F)C(F)F
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n/an/a 2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288297
PNG
(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...)
Show SMILES CCc1nc2c(C)cc(C(F)F)c(-c3cc(Cl)c4[nH]ncc4c3)n2n1
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n/an/a 2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288214
PNG
(7-Chloro-5-[2-ethyl-8-fluoro-6-(trifluoromethyl)-[...)
Show SMILES CCc1nc2c(F)cc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C17H11ClF4N4O/c1-2-12-23-16-11(19)6-9(17(20,21)22)15(26(16)25-12)8-3-7-5-13(27)24-14(7)10(18)4-8/h3-4,6H,2,5H2,1H3,(H,24,27)
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n/an/a 2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288299
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-ethoxy-8-methyl-6- ...)
Show SMILES CCOc1nc2c(C)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
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UniChem
n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288298
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2,8-dimethyl-6-(trifl...)
Show SMILES Cc1nc2c(C)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
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UniChem
n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288202
PNG
(5-[6-(Difluoromethyl)-2-(trifluoromethyl)-[1,2,4]t...)
Show SMILES COc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)C(F)F
Show InChI InChI=1S/C17H11F5N4O2/c1-28-10-5-8(4-7-6-12(27)24-13(7)10)14-9(15(18)19)2-3-11-23-16(17(20,21)22)25-26(11)14/h2-5,15H,6H2,1H3,(H,24,27)
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n/an/a 2.51n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288272
PNG
(2,8-Diethyl-5-(7-methyl-1H-indazol-5-yl)-6-(triflu...)
Show SMILES CCc1nc2c(CC)cc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F
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UniChem
n/an/a 3.16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288225
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-methoxy-6-(trifluor...)
Show SMILES COc1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
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UniChem
n/an/a 3.16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288277
PNG
(6-(Difluoromethyl)-8-methyl-5-(7-methyl-1H-indazol...)
Show SMILES CCCc1nc2c(C)cc(C(F)F)c(-c3cc(C)c4[nH]ncc4c3)n2n1
GoogleScholar
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UniChem
n/an/a 3.16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288228
PNG
(7-Chloro-5-(6-(difluoromethyl)-2-ethyl-[1,2,4]tria...)
Show SMILES CCc1nc2ccc(C(F)F)c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1
Show InChI InChI=1S/C17H13ClF2N4O/c1-2-12-21-13-4-3-10(17(19)20)16(24(13)23-12)9-5-8-7-14(25)22-15(8)11(18)6-9/h3-6,17H,2,7H2,1H3,(H,22,25)
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UniChem
n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288210
PNG
(5-(2-Ethyl-6-(trifluoromethyl)-[1,2,4]triazolo[1,5...)
Show SMILES CCc1nc2ccc(c(-c3cc4CC(=O)Nc4c(C)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4O/c1-3-13-22-14-5-4-12(18(19,20)21)17(25(14)24-13)11-6-9(2)16-10(7-11)8-15(26)23-16/h4-7H,3,8H2,1-2H3,(H,23,26)
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n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288212
PNG
(8-Chloro-2-ethyl-5-(7-methyl-1H-indazol-5-yl)-6-(t...)
Show SMILES CCc1nc2c(Cl)cc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
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UniChem
n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288290
PNG
(5-(8-Methyl-2,6-bis(trifluoromethyl)-[1,2,4]triazo...)
Show SMILES Cc1cc(c(-c2cc3CC(=O)Nc3c(c2)C#N)n2nc(nc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H9F6N5O/c1-7-2-11(17(19,20)21)14(29-15(7)27-16(28-29)18(22,23)24)9-3-8-5-12(30)26-13(8)10(4-9)6-25/h2-4H,5H2,1H3,(H,26,30)
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UniChem
n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288229
PNG
(5-(6-(Difluoromethyl)-2-ethyl-[1,2,4]triazolo[1,5-...)
Show SMILES CCc1nc2ccc(C(F)F)c(-c3cc4CC(=O)Nc4c(C)c3)n2n1
Show InChI InChI=1S/C18H16F2N4O/c1-3-13-21-14-5-4-12(18(19)20)17(24(14)23-13)11-6-9(2)16-10(7-11)8-15(25)22-16/h4-7,18H,3,8H2,1-2H3,(H,22,25)
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UniChem
n/an/a 3.98n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288194
PNG
(5-(2-(Difluoromethyl)-6-(trifluoromethyl)-[1,2,4]t...)
Show SMILES COc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)F)C(F)(F)F
Show InChI InChI=1S/C17H11F5N4O2/c1-28-10-5-8(4-7-6-12(27)24-13(7)10)14-9(17(20,21)22)2-3-11-23-16(15(18)19)25-26(11)14/h2-5,15H,6H2,1H3,(H,24,27)
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n/an/a 5.01n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288233
PNG
(6-Methoxy-5-(7-methyl-1H-indazol-5-yl)-2-(trifluor...)
Show SMILES COc1ccc2nc(nn2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
GoogleScholar
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UniChem
n/an/a 5.01n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288195
PNG
(5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-6-...)
Show SMILES COc1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 5.01n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288196
PNG
(2-(Difluoromethyl)-6-methoxy-5-(7-methyl-1H-indazo...)
Show SMILES COc1ccc2nc(nn2c1-c1cc(C)c2[nH]ncc2c1)C(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 5.01n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288241
PNG
(5-(7-Methyl-1H-indazol-5-yl)-6-(pyridin-4-yl)-2-(t...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccncc1
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UniChem
n/an/a 6.31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288205
PNG
(7-Chloro-5-(2-methyl-6-(trifluoromethyl)-[1,2,4]tr...)
Show SMILES Cc1nc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C16H10ClF3N4O/c1-7-21-12-3-2-10(16(18,19)20)15(24(12)23-7)9-4-8-6-13(25)22-14(8)11(17)5-9/h2-5H,6H2,1H3,(H,22,25)
GoogleScholar
AffyNet 
UniChem
n/an/a 10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288204
PNG
(2-Methyl-5-(7-methyl-1H-indazol-5-yl)-6-(trifluoro...)
Show SMILES Cc1nc2ccc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F
GoogleScholar
AffyNet 
UniChem
n/an/a 12.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))
BDBM288206
PNG
(7-Methyl-5-(2-methyl-6-(trifluoromethyl)-[1,2,4]tr...)
Show SMILES Cc1nc2ccc(c(-c3cc4CC(=O)Nc4c(C)c3)n2n1)C(F)(F)F
Show InChI InChI=1S/C17H13F3N4O/c1-8-5-11(6-10-7-14(25)22-15(8)10)16-12(17(18,19)20)3-4-13-21-9(2)23-24(13)16/h3-6H,7H2,1-2H3,(H,22,25)
GoogleScholar
AffyNet 
UniChem
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...


US Patent US10087185 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%