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Patent code US10092551

Compile Data Set for Download or QSAR
Found 173 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288715
PNG
(US10092551, Example 23)
Show SMILES FC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClFN2O2S/c24-17-7-5-15(6-8-17)18(13-25)20-21(28)26-22(30-20)27-11-9-23(10-12-27)19-4-2-1-3-16(19)14-29-23/h1-8H,9-14H2/b20-18-
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0.398n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288741
PNG
(US10092551, Example 49 | US10092551, Example 96)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-6-7-18(23)24-12-15)19-20(27)25-21(29-19)26-10-8-22(9-11-26)17-5-3-2-4-16(17)13-28-22/h2-7,12H,8-11,13H2,1H3/b19-14-
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0.398n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288850
PNG
(US10092551, Example 159)
Show SMILES CC(C)(C)OC(=O)NC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C28H31N3O4S/c1-27(2,3)35-26(33)29-17-21(19-9-5-4-6-10-19)23-24(32)30-25(36-23)31-15-13-28(14-16-31)22-12-8-7-11-20(22)18-34-28/h4-12H,13-18H2,1-3H3,(H,29,33)/b23-21-
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0.501n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288816
PNG
(US10092551, Example 124)
Show SMILES OC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H22N2O3S/c26-14-18(16-6-2-1-3-7-16)20-21(27)24-22(29-20)25-12-10-23(11-13-25)19-9-5-4-8-17(19)15-28-23/h1-9,26H,10-15H2/b20-18-
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0.501n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288862
PNG
(US10092551, Example 171)
Show SMILES [2H]C([2H])([2H])C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(Cl)nc1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-6-7-18(23)24-12-15)19-20(27)25-21(29-19)26-10-8-22(9-11-26)17-5-3-2-4-16(17)13-28-22/h2-7,12H,8-11,13H2,1H3/b19-14-/i1D3
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0.501n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288698
PNG
(US10092551, Example 6)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ncccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-4-6-16(23)7-5-15)19-20(27)25-21(29-19)26-11-8-22(9-12-26)17-3-2-10-24-18(17)13-28-22/h2-7,10H,8-9,11-13H2,1H3/b19-14-
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0.501n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288847
PNG
(US10092551, Example 156)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H20N2O3S/c1-15(16-7-3-2-4-8-16)19-20(26)24-22(29-19)25-13-11-23(12-14-25)18-10-6-5-9-17(18)21(27)28-23/h2-10H,11-14H2,1H3/b19-15-
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0.501n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288739
PNG
(US10092551, Example 47)
Show SMILES O=C1N=C(S\C1=C1\CCCCc2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C26H26N2O2S/c29-24-23(21-11-5-2-8-18-7-1-4-10-20(18)21)31-25(27-24)28-15-13-26(14-16-28)22-12-6-3-9-19(22)17-30-26/h1,3-4,6-7,9-10,12H,2,5,8,11,13-17H2/b23-21-
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0.501n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288693
PNG
(US10092551, Example 1 | US10092551, Example 26)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN2O2S/c1-15(16-6-8-18(24)9-7-16)20-21(27)25-22(29-20)26-12-10-23(11-13-26)19-5-3-2-4-17(19)14-28-23/h2-9H,10-14H2,1H3/b20-15-
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0.631n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288708
PNG
(US10092551, Example 151 | US10092551, Example 16)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H22N2O2S/c1-16(17-7-3-2-4-8-17)20-21(26)24-22(28-20)25-13-11-23(12-14-25)19-10-6-5-9-18(19)15-27-23/h2-10H,11-15H2,1H3/b20-16-
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0.631n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288824
PNG
(US10092551, Example 133)
Show SMILES CC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C23H22ClN3O2S/c1-2-17(15-7-8-19(24)25-13-15)20-21(28)26-22(30-20)27-11-9-23(10-12-27)18-6-4-3-5-16(18)14-29-23/h3-8,13H,2,9-12,14H2,1H3/b20-17-
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0.631n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288726
PNG
(US10092551, Example 34)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc[nH]1
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0.631n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288729
PNG
(US10092551, Example 37)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cccn1C
Show InChI InChI=1S/C22H23N3O2S/c1-15(18-8-5-11-24(18)2)19-20(26)23-21(28-19)25-12-9-22(10-13-25)17-7-4-3-6-16(17)14-27-22/h3-8,11H,9-10,12-14H2,1-2H3/b19-15-
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0.794n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288741
PNG
(US10092551, Example 49 | US10092551, Example 96)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-6-7-18(23)24-12-15)19-20(27)25-21(29-19)26-10-8-22(9-11-26)17-5-3-2-4-16(17)13-28-22/h2-7,12H,8-11,13H2,1H3/b19-14-
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0.794n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288753
PNG
(US10092551, Example 61)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cccnc1F
Show InChI InChI=1S/C22H20FN3O2S/c1-14(16-6-4-10-24-19(16)23)18-20(27)25-21(29-18)26-11-8-22(9-12-26)17-7-3-2-5-15(17)13-28-22/h2-7,10H,8-9,11-13H2,1H3/b18-14-
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0.794n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288710
PNG
(US10092551, Example 18)
Show SMILES FC(F)(F)C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18ClF3N2O2S/c24-16-7-5-14(6-8-16)18(23(25,26)27)19-20(30)28-21(32-19)29-11-9-22(10-12-29)17-4-2-1-3-15(17)13-31-22/h1-8H,9-13H2/b19-18+
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0.794n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288705
PNG
(US10092551, Example 13 | US10092551, Example 24)
Show SMILES CC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN2O2S/c1-2-19(16-7-9-18(25)10-8-16)21-22(28)26-23(30-21)27-13-11-24(12-14-27)20-6-4-3-5-17(20)15-29-24/h3-10H,2,11-15H2,1H3/b21-19-
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0.794n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288784
PNG
(US10092551, Example 92)
Show SMILES COC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C24H24N2O3S/c1-28-16-19(17-7-3-2-4-8-17)21-22(27)25-23(30-21)26-13-11-24(12-14-26)20-10-6-5-9-18(20)15-29-24/h2-10H,11-16H2,1H3/b21-19-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288781
PNG
(US10092551, Example 89)
Show SMILES Clc1ccc2CCCC\C(=C3\SC(=NC3=O)N3CCC4(CC3)OCc3ccccc43)c2c1
Show InChI InChI=1S/C26H25ClN2O2S/c27-19-10-9-17-5-1-3-7-20(21(17)15-19)23-24(30)28-25(32-23)29-13-11-26(12-14-29)22-8-4-2-6-18(22)16-31-26/h2,4,6,8-10,15H,1,3,5,7,11-14,16H2/b23-20-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288732
PNG
(US10092551, Example 40 | US10092551, Example 57)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1F
Show InChI InChI=1S/C23H21FN2O2S/c1-15(17-7-3-5-9-19(17)24)20-21(27)25-22(29-20)26-12-10-23(11-13-26)18-8-4-2-6-16(18)14-28-23/h2-9H,10-14H2,1H3/b20-15-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288843
PNG
(US10092551, Example 152)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H22N2O2S/c1-16(17-7-3-2-4-8-17)20-21(26)24-22(28-20)25-13-11-23(12-14-25)19-10-6-5-9-18(19)15-27-23/h2-10H,11-15H2,1H3/b20-16+
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288841
PNG
(US10092551, Example 150)
Show SMILES CC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C23H20ClN3O3S/c1-2-15(14-7-8-18(24)25-13-14)19-20(28)26-22(31-19)27-11-9-23(10-12-27)17-6-4-3-5-16(17)21(29)30-23/h3-8,13H,2,9-12H2,1H3/b19-15-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288818
PNG
(US10092551, Example 127)
Show SMILES OC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H22N2O3S/c26-14-18(16-6-2-1-3-7-16)20-21(27)24-22(29-20)25-12-10-23(11-13-25)19-9-5-4-8-17(19)15-28-23/h1-9,26H,10-15H2/b20-18+
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288814
PNG
(US10092551, Example 122)
Show SMILES O=C1N=C(SC1=C(c1ccc[nH]1)c1ccc[nH]1)N1CCC2(CC1)OCc1ccccc21
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288712
PNG
(US10092551, Example 20)
Show SMILES Clc1ccc2CCC\C(=C3\SC(=NC3=O)N3CCC4(CC3)OCc3ccccc43)c2c1
Show InChI InChI=1S/C25H23ClN2O2S/c26-18-9-8-16-5-3-6-19(20(16)14-18)22-23(29)27-24(31-22)28-12-10-25(11-13-28)21-7-2-1-4-17(21)15-30-25/h1-2,4,7-9,14H,3,5-6,10-13,15H2/b22-19-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288695
PNG
(US10092551, Example 3)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClN2O3S/c1-14(15-6-8-16(24)9-7-15)19-20(27)25-22(30-19)26-12-10-23(11-13-26)18-5-3-2-4-17(18)21(28)29-23/h2-9H,10-13H2,1H3/b19-14-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288755
PNG
(US10092551, Example 63)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1nccs1
Show InChI InChI=1S/C20H19N3O2S2/c1-13(18-21-8-11-26-18)16-17(24)22-19(27-16)23-9-6-20(7-10-23)15-5-3-2-4-14(15)12-25-20/h2-5,8,11H,6-7,9-10,12H2,1H3/b16-13-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288696
PNG
(US10092551, Example 4)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccncc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-2-4-17(23)5-3-15)19-20(27)25-21(29-19)26-10-7-22(8-11-26)18-12-24-9-6-16(18)13-28-22/h2-6,9,12H,7-8,10-11,13H2,1H3/b19-14-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288694
PNG
(US10092551, Example 2)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1cccnc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-4-6-17(23)7-5-15)18-20(27)25-21(29-18)26-11-8-22(9-12-26)19-16(13-28-22)3-2-10-24-19/h2-7,10H,8-9,11-13H2,1H3/b18-14-
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1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288727
PNG
(US10092551, Example 35)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccco1
Show InChI InChI=1S/C21H20N2O3S/c1-14(17-7-4-12-25-17)18-19(24)22-20(27-18)23-10-8-21(9-11-23)16-6-3-2-5-15(16)13-26-21/h2-7,12H,8-11,13H2,1H3/b18-14-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288732
PNG
(US10092551, Example 40 | US10092551, Example 57)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1F
Show InChI InChI=1S/C23H21FN2O2S/c1-15(17-7-3-5-9-19(17)24)20-21(27)25-22(29-20)26-12-10-23(11-13-26)18-8-4-2-6-16(18)14-28-23/h2-9H,10-14H2,1H3/b20-15-
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288806
PNG
(US10092551, Example 114)
Show SMILES CCCC(CCC)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C22H28N2O2S/c1-3-7-16(8-4-2)19-20(25)23-21(27-19)24-13-11-22(12-14-24)18-10-6-5-9-17(18)15-26-22/h5-6,9-10H,3-4,7-8,11-15H2,1-2H3
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288778
PNG
(US10092551, Example 86)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1oc(C)nc1C
Show InChI InChI=1S/C22H23N3O3S/c1-13(18-14(2)23-15(3)28-18)19-20(26)24-21(29-19)25-10-8-22(9-11-25)17-7-5-4-6-16(17)12-27-22/h4-7H,8-12H2,1-3H3/b19-13-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288821
PNG
(US10092551, Example 130)
Show SMILES OC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C22H20ClN3O3S/c23-18-6-5-14(11-24-18)16(12-27)19-20(28)25-21(30-19)26-9-7-22(8-10-26)17-4-2-1-3-15(17)13-29-22/h1-6,11,27H,7-10,12-13H2/b19-16-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288693
PNG
(US10092551, Example 1 | US10092551, Example 26)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN2O2S/c1-15(16-6-8-18(24)9-7-16)20-21(27)25-22(29-20)26-12-10-23(11-13-26)19-5-3-2-4-17(19)14-28-23/h2-9H,10-14H2,1H3/b20-15-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288697
PNG
(US10092551, Example 5)
Show SMILES C\C(=C1\SC(=NC1=O)N1[C@H]2CC[C@@H]1C[C@]1(C2)OC(=O)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H21ClN2O3S/c1-14(15-6-8-16(26)9-7-15)21-22(29)27-24(32-21)28-17-10-11-18(28)13-25(12-17)20-5-3-2-4-19(20)23(30)31-25/h2-9,17-18H,10-13H2,1H3/b21-14-/t17-,18+,25-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288779
PNG
(US10092551, Example 87)
Show SMILES O=C1N=C(S\C1=C1\COCc2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H22N2O3S/c27-22-21(19-15-28-13-16-5-1-3-7-18(16)19)30-23(25-22)26-11-9-24(10-12-26)20-8-4-2-6-17(20)14-29-24/h1-8H,9-15H2/b21-19-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288699
PNG
(US10092551, Example 7)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(C)nc1
Show InChI InChI=1S/C23H23N3O2S/c1-15-7-8-17(13-24-15)16(2)20-21(27)25-22(29-20)26-11-9-23(10-12-26)19-6-4-3-5-18(19)14-28-23/h3-8,13H,9-12,14H2,1-2H3/b20-16-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288731
PNG
(US10092551, Example 39)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cccnc1
Show InChI InChI=1S/C22H21N3O2S/c1-15(16-6-4-10-23-13-16)19-20(26)24-21(28-19)25-11-8-22(9-12-25)18-7-3-2-5-17(18)14-27-22/h2-7,10,13H,8-9,11-12,14H2,1H3/b19-15-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288807
PNG
(US10092551, Example 115)
Show SMILES O=C1N=C(SC1=C(C1CC1)C1CC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C22H24N2O2S/c25-20-19(18(14-5-6-14)15-7-8-15)27-21(23-20)24-11-9-22(10-12-24)17-4-2-1-3-16(17)13-26-22/h1-4,14-15H,5-13H2
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288831
PNG
(US10092551, Example 140)
Show SMILES CC(C)(C)[Si](C)(C)OC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccccc1
Show InChI InChI=1S/C29H34N2O4SSi/c1-28(2,3)37(4,5)34-19-22(20-11-7-6-8-12-20)24-25(32)30-27(36-24)31-17-15-29(16-18-31)23-14-10-9-13-21(23)26(33)35-29/h6-14H,15-19H2,1-5H3/b24-22-
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288863
PNG
(US10092551, Example 172)
Show SMILES [2H]C([2H])([2H])C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(Cl)nc1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-6-7-18(23)24-12-15)19-20(27)25-21(29-19)26-10-8-22(9-11-26)17-5-3-2-4-16(17)13-28-22/h2-7,12H,8-11,13H2,1H3/b19-14+/i1D3
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1.26n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288834
PNG
(US10092551, Example 143)
Show SMILES OC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H20N2O4S/c26-14-17(15-6-2-1-3-7-15)19-20(27)24-22(30-19)25-12-10-23(11-13-25)18-9-5-4-8-16(18)21(28)29-23/h1-9,26H,10-14H2/b19-17-
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288812
PNG
(US10092551, Example 120)
Show SMILES CC(C)C(C(C)C)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C22H28N2O2S/c1-14(2)18(15(3)4)19-20(25)23-21(27-19)24-11-9-22(10-12-24)17-8-6-5-7-16(17)13-26-22/h5-8,14-15H,9-13H2,1-4H3
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288735
PNG
(US10092551, Example 43)
Show SMILES C\C(C1CCCC1)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C22H26N2O2S/c1-15(16-6-2-3-7-16)19-20(25)23-21(27-19)24-12-10-22(11-13-24)18-9-5-4-8-17(18)14-26-22/h4-5,8-9,16H,2-3,6-7,10-14H2,1H3/b19-15-
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288860
PNG
(US10092551, Example 169)
Show SMILES [2H]C([2H])([2H])C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(C)nc1
Show InChI InChI=1S/C23H23N3O2S/c1-15-7-8-17(13-24-15)16(2)20-21(27)25-22(29-20)26-11-9-23(10-12-26)19-6-4-3-5-18(19)14-28-23/h3-8,13H,9-12,14H2,1-2H3/b20-16-/i2D3
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288730
PNG
(US10092551, Example 38)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccn1
Show InChI InChI=1S/C22H21N3O2S/c1-15(18-8-4-5-11-23-18)19-20(26)24-21(28-19)25-12-9-22(10-13-25)17-7-3-2-6-16(17)14-27-22/h2-8,11H,9-10,12-14H2,1H3/b19-15-
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288765
PNG
(US10092551, Example 73)
Show SMILES COC1CCCC\C1=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C22H26N2O3S/c1-26-18-9-5-3-7-16(18)19-20(25)23-21(28-19)24-12-10-22(11-13-24)17-8-4-2-6-15(17)14-27-22/h2,4,6,8,18H,3,5,7,9-14H2,1H3/b19-16-
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288775
PNG
(US10092551, Example 83)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cccnc1Cl
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(16-6-4-10-24-19(16)23)18-20(27)25-21(29-18)26-11-8-22(9-12-26)17-7-3-2-5-15(17)13-28-22/h2-7,10H,8-9,11-13H2,1H3/b18-14-
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288864
PNG
(US10092551, Example 173)
Show SMILES [2H]C([2H])([2H])C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccccc1
Show InChI InChI=1S/C23H22N2O2S/c1-16(17-7-3-2-4-8-17)20-21(26)24-22(28-20)25-13-11-23(12-14-25)19-10-6-5-9-18(19)15-27-23/h2-10H,11-15H2,1H3/b20-16-/i1D3
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288707
PNG
(US10092551, Example 15)
Show SMILES COCC(COC)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C20H24N2O4S/c1-24-11-15(12-25-2)17-18(23)21-19(27-17)22-9-7-20(8-10-22)16-6-4-3-5-14(16)13-26-20/h3-6H,7-13H2,1-2H3
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1.58n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288759
PNG
(US10092551, Example 67)
Show SMILES Clc1ccc2c(c1)C(=O)NCC\C2=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C25H22ClN3O3S/c26-16-5-6-17-18(7-10-27-22(30)19(17)13-16)21-23(31)28-24(33-21)29-11-8-25(9-12-29)20-4-2-1-3-15(20)14-32-25/h1-6,13H,7-12,14H2,(H,27,30)/b21-18-
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2n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288846
PNG
(US10092551, Example 155)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ncccc1C
Show InChI InChI=1S/C23H23N3O2S/c1-15-6-5-11-24-19(15)16(2)20-21(27)25-22(29-20)26-12-9-23(10-13-26)18-8-4-3-7-17(18)14-28-23/h3-8,11H,9-10,12-14H2,1-2H3/b20-16+
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2n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288797
PNG
(US10092551, Example 105)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1c(C)noc1C
Show InChI InChI=1S/C22H23N3O3S/c1-13(18-14(2)24-28-15(18)3)19-20(26)23-21(29-19)25-10-8-22(9-11-25)17-7-5-4-6-16(17)12-27-22/h4-7H,8-12H2,1-3H3/b19-13-
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2n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288721
PNG
(US10092551, Example 29)
Show SMILES C\C(C1CCCCC1)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C23H28N2O2S/c1-16(17-7-3-2-4-8-17)20-21(26)24-22(28-20)25-13-11-23(12-14-25)19-10-6-5-9-18(19)15-27-23/h5-6,9-10,17H,2-4,7-8,11-15H2,1H3/b20-16-
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2n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288737
PNG
(US10092551, Example 45)
Show SMILES O=C1N=C(S\C1=C1\CCCc2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C25H24N2O2S/c28-23-22(20-10-5-8-17-6-1-3-9-19(17)20)30-24(26-23)27-14-12-25(13-15-27)21-11-4-2-7-18(21)16-29-25/h1-4,6-7,9,11H,5,8,10,12-16H2/b22-20-
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2n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288865
PNG
(US10092551, Example 174)
Show SMILES [2H]C([2H])([2H])C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccccc1
Show InChI InChI=1S/C23H22N2O2S/c1-16(17-7-3-2-4-8-17)20-21(26)24-22(28-20)25-13-11-23(12-14-25)19-10-6-5-9-18(19)15-27-23/h2-10H,11-15H2,1H3/b20-16+/i1D3
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2n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288790
PNG
(US10092551, Example 98)
Show SMILES O=C1N=C(SC1=C1c2ccccc2CCc2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C30H26N2O2S/c33-28-27(26-23-10-4-1-7-20(23)13-14-21-8-2-5-11-24(21)26)35-29(31-28)32-17-15-30(16-18-32)25-12-6-3-9-22(25)19-34-30/h1-12H,13-19H2
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2.51n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288804
PNG
(US10092551, Example 112)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1sc(C)nc1C
Show InChI InChI=1S/C22H23N3O2S2/c1-13(18-14(2)23-15(3)28-18)19-20(26)24-21(29-19)25-10-8-22(9-11-25)17-7-5-4-6-16(17)12-27-22/h4-7H,8-12H2,1-3H3/b19-13-
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2.51n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288740
PNG
(US10092551, Example 48)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccnc(Cl)c1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-6-9-24-18(23)12-15)19-20(27)25-21(29-19)26-10-7-22(8-11-26)17-5-3-2-4-16(17)13-28-22/h2-6,9,12H,7-8,10-11,13H2,1H3/b19-14-
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2.51n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288756
PNG
(US10092551, Example 64)
Show SMILES CC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cc(C)on1
Show InChI InChI=1S/C22H23N3O3S/c1-3-16(18-12-14(2)28-24-18)19-20(26)23-21(29-19)25-10-8-22(9-11-25)17-7-5-4-6-15(17)13-27-22/h4-7,12H,3,8-11,13H2,1-2H3/b19-16-
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2.51n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288795
PNG
(US10092551, Example 103)
Show SMILES O=C1N=C(SC1=C1c2ccccc2Oc2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C28H22N2O3S/c31-26-25(24-19-8-2-5-11-22(19)33-23-12-6-3-9-20(23)24)34-27(29-26)30-15-13-28(14-16-30)21-10-4-1-7-18(21)17-32-28/h1-12H,13-17H2
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2.51n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288794
PNG
(US10092551, Example 102)
Show SMILES O=C1N=C(SC1=C1c2ccccc2Sc2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C28H22N2O2S2/c31-26-25(24-19-8-2-5-11-22(19)33-23-12-6-3-9-20(23)24)34-27(29-26)30-15-13-28(14-16-30)21-10-4-1-7-18(21)17-32-28/h1-12H,13-17H2
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2.51n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288708
PNG
(US10092551, Example 151 | US10092551, Example 16)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H22N2O2S/c1-16(17-7-3-2-4-8-17)20-21(26)24-22(28-20)25-13-11-23(12-14-25)19-10-6-5-9-18(19)15-27-23/h2-10H,11-15H2,1H3/b20-16-
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3.16n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288815
PNG
(US10092551, Example 123)
Show SMILES CC(C)(C)[Si](C)(C)OC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C29H36N2O3SSi/c1-28(2,3)36(4,5)34-20-23(21-11-7-6-8-12-21)25-26(32)30-27(35-25)31-17-15-29(16-18-31)24-14-10-9-13-22(24)19-33-29/h6-14H,15-20H2,1-5H3/b25-23-
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3.16n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288744
PNG
(US10092551, Example 52)
Show SMILES O=C1N=C(SC1=C1CCCCC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C21H24N2O2S/c24-19-18(15-6-2-1-3-7-15)26-20(22-19)23-12-10-21(11-13-23)17-9-5-4-8-16(17)14-25-21/h4-5,8-9H,1-3,6-7,10-14H2
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3.16n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288706
PNG
(US10092551, Example 14)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1Cl
Show InChI InChI=1S/C23H21ClN2O2S/c1-15(17-7-3-5-9-19(17)24)20-21(27)25-22(29-20)26-12-10-23(11-13-26)18-8-4-2-6-16(18)14-28-23/h2-9H,10-14H2,1H3/b20-15-
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3.16n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288830
PNG
(US10092551, Example 139)
Show SMILES O=C1OC2(CCN(CC2)C2=NC(=O)C(S2)=C(C2CC2)C2CC2)c2ccccc12
Show InChI InChI=1S/C22H22N2O3S/c25-19-18(17(13-5-6-13)14-7-8-14)28-21(23-19)24-11-9-22(10-12-24)16-4-2-1-3-15(16)20(26)27-22/h1-4,13-14H,5-12H2
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3.16n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288709
PNG
(US10092551, Example 17)
Show SMILES FC(F)(F)C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18ClF3N2O2S/c24-16-7-5-14(6-8-16)18(23(25,26)27)19-20(30)28-21(32-19)29-11-9-22(10-12-29)17-4-2-1-3-15(17)13-31-22/h1-8H,9-13H2/b19-18-
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3.16n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288789
PNG
(US10092551, Example 97)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(15-6-7-18(23)24-12-15)19-20(27)25-21(29-19)26-10-8-22(9-11-26)17-5-3-2-4-16(17)13-28-22/h2-7,12H,8-11,13H2,1H3/b19-14+
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3.16n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288703
PNG
(US10092551, Example 11)
Show SMILES Clc1ccc2\C(CCCc2c1)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C25H23ClN2O2S/c26-18-8-9-19-16(14-18)5-3-6-20(19)22-23(29)27-24(31-22)28-12-10-25(11-13-28)21-7-2-1-4-17(21)15-30-25/h1-2,4,7-9,14H,3,5-6,10-13,15H2/b22-20-
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288734
PNG
(US10092551, Example 42)
Show SMILES C\C(C1CC1)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C20H22N2O2S/c1-13(14-6-7-14)17-18(23)21-19(25-17)22-10-8-20(9-11-22)16-5-3-2-4-15(16)12-24-20/h2-5,14H,6-12H2,1H3/b17-13-
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288701
PNG
(US10092551, Example 9)
Show SMILES O=C1N=C(S\C1=C/c1ccccc1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C22H20N2O2S/c25-20-19(14-16-6-2-1-3-7-16)27-21(23-20)24-12-10-22(11-13-24)18-9-5-4-8-17(18)15-26-22/h1-9,14H,10-13,15H2/b19-14-
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288777
PNG
(US10092551, Example 85)
Show SMILES COc1ccc(cn1)C(\C)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C23H23N3O3S/c1-15(16-7-8-19(28-2)24-13-16)20-21(27)25-22(30-20)26-11-9-23(10-12-26)18-6-4-3-5-17(18)14-29-23/h3-8,13H,9-12,14H2,1-2H3/b20-15-
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288774
PNG
(US10092551, Example 82)
Show SMILES O=C1N=C(SC1=C(c1ccccc1)c1ccccc1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C28H24N2O2S/c31-26-25(24(20-9-3-1-4-10-20)21-11-5-2-6-12-21)33-27(29-26)30-17-15-28(16-18-30)23-14-8-7-13-22(23)19-32-28/h1-14H,15-19H2
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288723
PNG
(US10092551, Example 31)
Show SMILES CC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccncc1
Show InChI InChI=1S/C23H23N3O2S/c1-2-18(16-7-11-24-12-8-16)20-21(27)25-22(29-20)26-13-9-23(10-14-26)19-6-4-3-5-17(19)15-28-23/h3-8,11-12H,2,9-10,13-15H2,1H3/b20-18-
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288849
PNG
(US10092551, Example 158)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccncc1F
Show InChI InChI=1S/C22H20FN3O2S/c1-14(16-6-9-24-12-18(16)23)19-20(27)25-21(29-19)26-10-7-22(8-11-26)17-5-3-2-4-15(17)13-28-22/h2-6,9,12H,7-8,10-11,13H2,1H3/b19-14-
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288742
PNG
(US10092551, Example 50)
Show SMILES COC\C(C)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C19H22N2O3S/c1-13(11-23-2)16-17(22)20-18(25-16)21-9-7-19(8-10-21)15-6-4-3-5-14(15)12-24-19/h3-6H,7-12H2,1-2H3/b16-13-
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288791
PNG
(US10092551, Example 99)
Show SMILES O=C1N=C(SC1=C1c2ccccc2C=Cc2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C30H24N2O2S/c33-28-27(26-23-10-4-1-7-20(23)13-14-21-8-2-5-11-24(21)26)35-29(31-28)32-17-15-30(16-18-32)25-12-6-3-9-22(25)19-34-30/h1-14H,15-19H2
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288833
PNG
(US10092551, Example 142)
Show SMILES OC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H20N2O4S/c26-14-17(15-6-2-1-3-7-15)19-20(27)24-22(30-19)25-12-10-23(11-13-25)18-9-5-4-8-16(18)21(28)29-23/h1-9,26H,10-14H2/b19-17+
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288771
PNG
(US10092551, Example 79)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cc(C)on1
Show InChI InChI=1S/C21H21N3O3S/c1-13-11-17(23-27-13)14(2)18-19(25)22-20(28-18)24-9-7-21(8-10-24)16-6-4-3-5-15(16)12-26-21/h3-6,11H,7-10,12H2,1-2H3/b18-14-
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3.98n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288719
PNG
(US10092551, Example 27)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN2O2S/c1-15(16-6-8-18(24)9-7-16)20-21(27)25-22(29-20)26-12-10-23(11-13-26)19-5-3-2-4-17(19)14-28-23/h2-9H,10-14H2,1H3/b20-15+
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288748
PNG
(US10092551, Example 56)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1F
Show InChI InChI=1S/C23H21FN2O2S/c1-15(17-7-3-5-9-19(17)24)20-21(27)25-22(29-20)26-12-10-23(11-13-26)18-8-4-2-6-16(18)14-28-23/h2-9H,10-14H2,1H3/b20-15+
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288763
PNG
(US10092551, Example 71)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)C(F)(F)F
Show InChI InChI=1S/C18H17F3N2O2S/c1-11(18(19,20)21)14-15(24)22-16(26-14)23-8-6-17(7-9-23)13-5-3-2-4-12(13)10-25-17/h2-5H,6-10H2,1H3/b14-11-
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288844
PNG
(US10092551, Example 153)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(C)nc1
Show InChI InChI=1S/C23H23N3O2S/c1-15-7-8-17(13-24-15)16(2)20-21(27)25-22(29-20)26-11-9-23(10-12-26)19-6-4-3-5-18(19)14-28-23/h3-8,13H,9-12,14H2,1-2H3/b20-16+
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288747
PNG
(US10092551, Example 55)
Show SMILES O=C1N=C(S\C1=C1\CC2C3C4CC2C1C34)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H24N2O2S/c27-22-21(16-10-14-13-9-15-18(14)20(15)19(13)16)29-23(25-22)26-7-5-24(6-8-26)17-4-2-1-3-12(17)11-28-24/h1-4,13-15,18-20H,5-11H2/b21-16-
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288829
PNG
(US10092551, Example 138)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C22H18ClN3O3S/c1-13(14-6-7-17(23)24-12-14)18-19(27)25-21(30-18)26-10-8-22(9-11-26)16-5-3-2-4-15(16)20(28)29-22/h2-7,12H,8-11H2,1H3/b18-13+
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288754
PNG
(US10092551, Example 62)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cnn(C)c1
Show InChI InChI=1S/C21H22N4O2S/c1-14(16-11-22-24(2)12-16)18-19(26)23-20(28-18)25-9-7-21(8-10-25)17-6-4-3-5-15(17)13-27-21/h3-6,11-12H,7-10,13H2,1-2H3/b18-14-
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288738
PNG
(US10092551, Example 46)
Show SMILES O=C1N=C(S\C1=C1\CCc2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H22N2O2S/c27-22-21(19-10-9-16-5-1-3-7-18(16)19)29-23(25-22)26-13-11-24(12-14-26)20-8-4-2-6-17(20)15-28-24/h1-8H,9-15H2/b21-19-
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288745
PNG
(US10092551, Example 53)
Show SMILES O=C1N=C(SC1=C1CCCC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C20H22N2O2S/c23-18-17(14-5-1-2-6-14)25-19(21-18)22-11-9-20(10-12-22)16-8-4-3-7-15(16)13-24-20/h3-4,7-8H,1-2,5-6,9-13H2
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288764
PNG
(US10092551, Example 72)
Show SMILES CC(=O)OCC(COC(C)=O)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C22H24N2O6S/c1-14(25)28-11-17(12-29-15(2)26)19-20(27)23-21(31-19)24-9-7-22(8-10-24)18-6-4-3-5-16(18)13-30-22/h3-6H,7-13H2,1-2H3
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288808
PNG
(US10092551, Example 116)
Show SMILES CC(C)CC(CC(C)C)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H32N2O2S/c1-16(2)13-19(14-17(3)4)21-22(27)25-23(29-21)26-11-9-24(10-12-26)20-8-6-5-7-18(20)15-28-24/h5-8,16-17H,9-15H2,1-4H3
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5.01n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288725
PNG
(US10092551, Example 33)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccncc1
Show InChI InChI=1S/C22H21N3O2S/c1-15(16-6-10-23-11-7-16)19-20(26)24-21(28-19)25-12-8-22(9-13-25)18-5-3-2-4-17(18)14-27-22/h2-7,10-11H,8-9,12-14H2,1H3/b19-15-
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288851
PNG
(US10092551, Example 160)
Show SMILES OC(=O)C(F)(F)F.NC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H23N3O2S.C2HF3O2/c24-14-18(16-6-2-1-3-7-16)20-21(27)25-22(29-20)26-12-10-23(11-13-26)19-9-5-4-8-17(19)15-28-23;3-2(4,5)1(6)7/h1-9H,10-15,24H2;(H,6,7)/b20-18-;
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288859
PNG
(US10092551, Example 168)
Show SMILES O=C1N=C(S\C1=C1\COCc2ccccc12)N1CCC2(CC1)OCc1ncccc21
Show InChI InChI=1S/C23H21N3O3S/c27-21-20(17-13-28-12-15-4-1-2-5-16(15)17)30-22(25-21)26-10-7-23(8-11-26)18-6-3-9-24-19(18)14-29-23/h1-6,9H,7-8,10-14H2/b20-17-
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6.31n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288704
PNG
(US10092551, Example 12)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClN2O2S/c1-15(16-6-4-7-18(24)13-16)20-21(27)25-22(29-20)26-11-9-23(10-12-26)19-8-3-2-5-17(19)14-28-23/h2-8,13H,9-12,14H2,1H3/b20-15-
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6.31n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288840
PNG
(US10092551, Example 149)
Show SMILES CC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C23H20ClN3O3S/c1-2-15(14-7-8-18(24)25-13-14)19-20(28)26-22(31-19)27-11-9-23(10-12-27)17-6-4-3-5-16(17)21(29)30-23/h3-8,13H,2,9-12H2,1H3/b19-15+
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6.31n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288820
PNG
(US10092551, Example 129)
Show SMILES CC(C)(C)[Si](C)(C)OC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C28H34ClN3O3SSi/c1-27(2,3)37(4,5)35-18-21(19-10-11-23(29)30-16-19)24-25(33)31-26(36-24)32-14-12-28(13-15-32)22-9-7-6-8-20(22)17-34-28/h6-11,16H,12-15,17-18H2,1-5H3/b24-21-
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6.31n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288717
PNG
(US10092551, Example 25)
Show SMILES CC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN2O2S/c1-2-19(16-7-9-18(25)10-8-16)21-22(28)26-23(30-21)27-13-11-24(12-14-27)20-6-4-3-5-17(20)15-29-24/h3-10H,2,11-15H2,1H3/b21-19+
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6.31n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288796
PNG
(US10092551, Example 104)
Show SMILES O=C1N=C(SC1=C1c2ccccc2-c2ccccc12)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C28H22N2O2S/c31-26-25(24-21-10-4-2-8-19(21)20-9-3-5-11-22(20)24)33-27(29-26)30-15-13-28(14-16-30)23-12-6-1-7-18(23)17-32-28/h1-12H,13-17H2
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6.31n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288736
PNG
(US10092551, Example 44)
Show SMILES O=C1N=C(SC1=C1CCOCC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C20H22N2O3S/c23-18-17(14-5-11-24-12-6-14)26-19(21-18)22-9-7-20(8-10-22)16-4-2-1-3-15(16)13-25-20/h1-4H,5-13H2
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7.94n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288783
PNG
(US10092551, Example 91 | US10092551, Example 93)
Show SMILES Cc1cc(\C=C2/SC(=NC2=O)N2CCC3(CC2)OCc2ccccc32)no1
Show InChI InChI=1S/C20H19N3O3S/c1-13-10-15(22-26-13)11-17-18(24)21-19(27-17)23-8-6-20(7-9-23)16-5-3-2-4-14(16)12-25-20/h2-5,10-11H,6-9,12H2,1H3/b17-11-
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7.94n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288836
PNG
(US10092551, Example 145)
Show SMILES OC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C22H18ClN3O4S/c23-17-6-5-13(11-24-17)15(12-27)18-19(28)25-21(31-18)26-9-7-22(8-10-26)16-4-2-1-3-14(16)20(29)30-22/h1-6,11,27H,7-10,12H2/b18-15-
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288793
PNG
(US10092551, Example 101)
Show SMILES Fc1ccc(cc1)C(=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(F)cc1
Show InChI InChI=1S/C28H22F2N2O2S/c29-21-9-5-18(6-10-21)24(19-7-11-22(30)12-8-19)25-26(33)31-27(35-25)32-15-13-28(14-16-32)23-4-2-1-3-20(23)17-34-28/h1-12H,13-17H2
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288835
PNG
(US10092551, Example 144)
Show SMILES CC(C)(C)[Si](C)(C)OC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C28H32ClN3O4SSi/c1-27(2,3)38(4,5)35-17-20(18-10-11-22(29)30-16-18)23-24(33)31-26(37-23)32-14-12-28(13-15-32)21-9-7-6-8-19(21)25(34)36-28/h6-11,16H,12-15,17H2,1-5H3/b23-20-
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288825
PNG
(US10092551, Example 134)
Show SMILES CC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C23H22ClN3O2S/c1-2-17(15-7-8-19(24)25-13-15)20-21(28)26-22(30-20)27-11-9-23(10-12-27)18-6-4-3-5-16(18)14-29-23/h3-8,13H,2,9-12,14H2,1H3/b20-17+
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288705
PNG
(US10092551, Example 13 | US10092551, Example 24)
Show SMILES CC\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN2O2S/c1-2-19(16-7-9-18(25)10-8-16)21-22(28)26-23(30-21)27-13-11-24(12-14-27)20-6-4-3-5-17(20)15-29-24/h3-10H,2,11-15H2,1H3/b21-19-
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288761
PNG
(US10092551, Example 69)
Show SMILES FCC(CF)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C18H18F2N2O2S/c19-9-13(10-20)15-16(23)21-17(25-15)22-7-5-18(6-8-22)14-4-2-1-3-12(14)11-24-18/h1-4H,5-11H2
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288828
PNG
(US10092551, Example 137)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C22H18ClN3O3S/c1-13(14-6-7-17(23)24-12-14)18-19(27)25-21(30-18)26-10-8-22(9-11-26)16-5-3-2-4-15(16)20(28)29-22/h2-7,12H,8-11H2,1H3/b18-13-
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288838
PNG
(US10092551, Example 147)
Show SMILES OC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C22H18ClN3O4S/c23-17-6-5-13(11-24-17)15(12-27)18-19(28)25-21(31-18)26-9-7-22(8-10-26)16-4-2-1-3-14(16)20(29)30-22/h1-6,11,27H,7-10,12H2/b18-15+
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288861
PNG
(US10092551, Example 170)
Show SMILES [2H]C([2H])([2H])C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(C)nc1
Show InChI InChI=1S/C23H23N3O2S/c1-15-7-8-17(13-24-15)16(2)20-21(27)25-22(29-20)26-11-9-23(10-12-26)19-6-4-3-5-18(19)14-28-23/h3-8,13H,9-12,14H2,1-2H3/b20-16+/i2D3
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288752
PNG
(US10092551, Example 60)
Show SMILES O=C1N=C(SC1=C1CCS(=O)(=O)CC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C20H22N2O4S2/c23-18-17(14-5-11-28(24,25)12-6-14)27-19(21-18)22-9-7-20(8-10-22)16-4-2-1-3-15(16)13-26-20/h1-4H,5-13H2
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10n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288853
PNG
(US10092551, Example 162)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ncccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C21H19ClN4O2S/c1-13(14-4-5-17(22)24-11-14)18-19(27)25-20(29-18)26-9-6-21(7-10-26)15-3-2-8-23-16(15)12-28-21/h2-5,8,11H,6-7,9-10,12H2,1H3/b18-13-
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12.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288720
PNG
(US10092551, Example 28)
Show SMILES C\C(C1CCCCC1)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C23H28N2O2S/c1-16(17-7-3-2-4-8-17)20-21(26)24-22(28-20)25-13-11-23(12-14-25)19-10-6-5-9-18(19)15-27-23/h5-6,9-10,17H,2-4,7-8,11-15H2,1H3/b20-16+
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12.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288713
PNG
(US10092551, Example 21)
Show SMILES CC(C)(C)C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN2O2S/c1-25(2,3)21(17-8-10-19(27)11-9-17)22-23(30)28-24(32-22)29-14-12-26(13-15-29)20-7-5-4-6-18(20)16-31-26/h4-11H,12-16H2,1-3H3/b22-21+
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12.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288724
PNG
(US10092551, Example 32)
Show SMILES CC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccncc1
Show InChI InChI=1S/C23H23N3O2S/c1-2-18(16-7-11-24-12-8-16)20-21(27)25-22(29-20)26-13-9-23(10-14-26)19-6-4-3-5-17(19)15-28-23/h3-8,11-12H,2,9-10,13-15H2,1H3/b20-18+
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12.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288826
PNG
(US10092551, Example 135)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(C)nc1
Show InChI InChI=1S/C23H21N3O3S/c1-14-7-8-16(13-24-14)15(2)19-20(27)25-22(30-19)26-11-9-23(10-12-26)18-6-4-3-5-17(18)21(28)29-23/h3-8,13H,9-12H2,1-2H3/b19-15-
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12.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288743
PNG
(US10092551, Example 51)
Show SMILES C\C(CF)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C18H19FN2O2S/c1-12(10-19)15-16(22)20-17(24-15)21-8-6-18(7-9-21)14-5-3-2-4-13(14)11-23-18/h2-5H,6-11H2,1H3/b15-12-
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12.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288770
PNG
(US10092551, Example 78)
Show SMILES C\C(C1CCOCC1)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C22H26N2O3S/c1-15(16-6-12-26-13-7-16)19-20(25)23-21(28-19)24-10-8-22(9-11-24)18-5-3-2-4-17(18)14-27-22/h2-5,16H,6-14H2,1H3/b19-15-
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12.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288848
PNG
(US10092551, Example 157)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccccc1
Show InChI InChI=1S/C23H20N2O3S/c1-15(16-7-3-2-4-8-16)19-20(26)24-22(29-19)25-13-11-23(12-14-25)18-10-6-5-9-17(18)21(27)28-23/h2-10H,11-14H2,1H3/b19-15+
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15.8n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288822
PNG
(US10092551, Example 131)
Show SMILES CC(C)(C)[Si](C)(C)OC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C28H34ClN3O3SSi/c1-27(2,3)37(4,5)35-18-21(19-10-11-23(29)30-16-19)24-25(33)31-26(36-24)32-14-12-28(13-15-32)22-9-7-6-8-20(22)17-34-28/h6-11,16H,12-15,17-18H2,1-5H3/b24-21+
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15.8n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288700
PNG
(US10092551, Example 8)
Show SMILES Clc1ccc(\C=C2/SC(=NC2=O)N2CCC3(CC2)OCc2ccccc32)cc1
Show InChI InChI=1S/C22H19ClN2O2S/c23-17-7-5-15(6-8-17)13-19-20(26)24-21(28-19)25-11-9-22(10-12-25)18-4-2-1-3-16(18)14-27-22/h1-8,13H,9-12,14H2/b19-13-
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288845
PNG
(US10092551, Example 154)
Show SMILES CC(C)C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(Cl)cc1
Show InChI InChI=1S/C25H25ClN2O2S/c1-16(2)21(17-7-9-19(26)10-8-17)22-23(29)27-24(31-22)28-13-11-25(12-14-28)20-6-4-3-5-18(20)15-30-25/h3-10,16H,11-15H2,1-2H3/b22-21+
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15.8n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288823
PNG
(US10092551, Example 132)
Show SMILES CC(C)C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)\c1ccc(Cl)nc1
Show InChI InChI=1S/C24H24ClN3O2S/c1-15(2)20(16-7-8-19(25)26-13-16)21-22(29)27-23(31-21)28-11-9-24(10-12-28)18-6-4-3-5-17(18)14-30-24/h3-8,13,15H,9-12,14H2,1-2H3/b21-20+
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15.8n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288722
PNG
(US10092551, Example 30)
Show SMILES CC(C)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C18H20N2O2S/c1-12(2)15-16(21)19-17(23-15)20-9-7-18(8-10-20)14-6-4-3-5-13(14)11-22-18/h3-6H,7-11H2,1-2H3
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15.8n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288714
PNG
(US10092551, Example 22)
Show SMILES Clc1ccc(cc1)C(\C1CC1)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C25H23ClN2O2S/c26-19-9-7-17(8-10-19)21(16-5-6-16)22-23(29)27-24(31-22)28-13-11-25(12-14-28)20-4-2-1-3-18(20)15-30-25/h1-4,7-10,16H,5-6,11-15H2/b22-21-
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288852
PNG
(US10092551, Example 161)
Show SMILES O=C1N=C(SC1=C1Cc2ccccc2C1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H22N2O2S/c27-22-21(19-13-16-5-1-2-6-17(16)14-19)29-23(25-22)26-11-9-24(10-12-26)20-8-4-3-7-18(20)15-28-24/h1-8H,9-15H2
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288768
PNG
(US10092551, Example 76)
Show SMILES O=C1N=C(S\C1=C1\CCCOC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C20H22N2O3S/c23-18-17(15-5-3-11-24-12-15)26-19(21-18)22-9-7-20(8-10-22)16-6-2-1-4-14(16)13-25-20/h1-2,4,6H,3,5,7-13H2/b17-15-
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288757
PNG
(US10092551, Example 65)
Show SMILES C\C(CNC(=O)OC(C)(C)C)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C23H29N3O4S/c1-15(13-24-21(28)30-22(2,3)4)18-19(27)25-20(31-18)26-11-9-23(10-12-26)17-8-6-5-7-16(17)14-29-23/h5-8H,9-14H2,1-4H3,(H,24,28)/b18-15+
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288776
PNG
(US10092551, Example 84)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cccnc1Cl
Show InChI InChI=1S/C22H20ClN3O2S/c1-14(16-6-4-10-24-19(16)23)18-20(27)25-21(29-18)26-11-8-22(9-12-26)17-7-3-2-5-15(17)13-28-22/h2-7,10H,8-9,11-13H2,1H3/b18-14+
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288760
PNG
(US10092551, Example 68)
Show SMILES CS(=O)(=O)N1CCC(CC1)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C21H25N3O4S2/c1-30(26,27)24-10-6-15(7-11-24)18-19(25)22-20(29-18)23-12-8-21(9-13-23)17-5-3-2-4-16(17)14-28-21/h2-5H,6-14H2,1H3
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20n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288711
PNG
(US10092551, Example 19)
Show SMILES Clc1cccc2\C(CCCc12)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C25H23ClN2O2S/c26-21-10-4-6-17-18(21)7-3-8-19(17)22-23(29)27-24(31-22)28-13-11-25(12-14-28)20-9-2-1-5-16(20)15-30-25/h1-2,4-6,9-10H,3,7-8,11-15H2/b22-19-
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288810
PNG
(US10092551, Example 118)
Show SMILES O=C1N=C(SC1=C(C1CCCC1)C1CCCC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C26H32N2O2S/c29-24-23(22(18-7-1-2-8-18)19-9-3-4-10-19)31-25(27-24)28-15-13-26(14-16-28)21-12-6-5-11-20(21)17-30-26/h5-6,11-12,18-19H,1-4,7-10,13-17H2
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25.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288733
PNG
(US10092551, Example 41)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C25H31N3O4S/c1-24(2,3)32-23(30)28-12-8-17(9-13-28)20-21(29)26-22(33-20)27-14-10-25(11-15-27)19-7-5-4-6-18(19)16-31-25/h4-7H,8-16H2,1-3H3
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25.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288832
PNG
(US10092551, Example 141)
Show SMILES CC(C)(C)[Si](C)(C)OC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccccc1
Show InChI InChI=1S/C29H34N2O4SSi/c1-28(2,3)37(4,5)34-19-22(20-11-7-6-8-12-20)24-25(32)30-27(36-24)31-17-15-29(16-18-31)23-14-10-9-13-21(23)26(33)35-29/h6-14H,15-19H2,1-5H3/b24-22+
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288762
PNG
(US10092551, Example 70)
Show SMILES C\C(C=C)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C19H20N2O2S/c1-3-13(2)16-17(22)20-18(24-16)21-10-8-19(9-11-21)15-7-5-4-6-14(15)12-23-19/h3-7H,1,8-12H2,2H3/b16-13-
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25.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288802
PNG
(US10092551, Example 110)
Show SMILES O=C1N=C(SC1=C(c1ccccn1)c1ccccn1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C26H22N4O2S/c31-24-23(22(20-9-3-5-13-27-20)21-10-4-6-14-28-21)33-25(29-24)30-15-11-26(12-16-30)19-8-2-1-7-18(19)17-32-26/h1-10,13-14H,11-12,15-17H2
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25.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288767
PNG
(US10092551, Example 75)
Show SMILES O=C1N=C(SC1=C1CCC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C19H20N2O2S/c22-17-16(13-5-3-6-13)24-18(20-17)21-10-8-19(9-11-21)15-7-2-1-4-14(15)12-23-19/h1-2,4,7H,3,5-6,8-12H2
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288769
PNG
(US10092551, Example 77)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccnc(C)c1
Show InChI InChI=1S/C23H23N3O2S/c1-15-13-17(7-10-24-15)16(2)20-21(27)25-22(29-20)26-11-8-23(9-12-26)19-6-4-3-5-18(19)14-28-23/h3-7,10,13H,8-9,11-12,14H2,1-2H3/b20-16-
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288819
PNG
(US10092551, Example 128)
Show SMILES O=C1N=C(S\C1=C1\CCC=C1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C20H20N2O2S/c23-18-17(14-5-1-2-6-14)25-19(21-18)22-11-9-20(10-12-22)16-8-4-3-7-15(16)13-24-20/h1,3-5,7-8H,2,6,9-13H2/b17-14+
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288811
PNG
(US10092551, Example 119)
Show SMILES O=C1N=C(SC1=C(c1cccnc1)c1cccnc1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C26H22N4O2S/c31-24-23(22(18-6-3-11-27-15-18)19-7-4-12-28-16-19)33-25(29-24)30-13-9-26(10-14-30)21-8-2-1-5-20(21)17-32-26/h1-8,11-12,15-16H,9-10,13-14,17H2
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288856
PNG
(US10092551, Example 165)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ncccc21)c1cccnc1
Show InChI InChI=1S/C21H20N4O2S/c1-14(15-4-2-8-22-12-15)18-19(26)24-20(28-18)25-10-6-21(7-11-25)16-5-3-9-23-17(16)13-27-21/h2-5,8-9,12H,6-7,10-11,13H2,1H3/b18-14-
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288766
PNG
(US10092551, Example 74)
Show SMILES O=C1Nc2ccccc2\C1=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C23H19N3O3S/c27-20-18(15-6-2-4-8-17(15)24-20)19-21(28)25-22(30-19)26-11-9-23(10-12-26)16-7-3-1-5-14(16)13-29-23/h1-8H,9-13H2,(H,24,27)/b19-18+
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288803
PNG
(US10092551, Example 111)
Show SMILES FC(F)(F)C(=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)C(F)(F)F
Show InChI InChI=1S/C18H14F6N2O2S/c19-17(20,21)13(18(22,23)24)12-14(27)25-15(29-12)26-7-5-16(6-8-26)11-4-2-1-3-10(11)9-28-16/h1-4H,5-9H2
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288728
PNG
(US10092551, Example 36)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccncc1
Show InChI InChI=1S/C22H21N3O2S/c1-15(16-6-10-23-11-7-16)19-20(26)24-21(28-19)25-12-8-22(9-13-25)18-5-3-2-4-17(18)14-27-22/h2-7,10-11H,8-9,12-14H2,1H3/b19-15+
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Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288746
PNG
(US10092551, Example 54)
Show SMILES Oc1ccc2\C(CCc2c1)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H22N2O3S/c27-17-6-8-18-15(13-17)5-7-19(18)21-22(28)25-23(30-21)26-11-9-24(10-12-26)20-4-2-1-3-16(20)14-29-24/h1-4,6,8,13,27H,5,7,9-12,14H2/b21-19-
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31.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288783
PNG
(US10092551, Example 91 | US10092551, Example 93)
Show SMILES Cc1cc(\C=C2/SC(=NC2=O)N2CCC3(CC2)OCc2ccccc32)no1
Show InChI InChI=1S/C20H19N3O3S/c1-13-10-15(22-26-13)11-17-18(24)21-19(27-17)23-8-6-20(7-9-23)16-5-3-2-4-14(16)12-25-20/h2-5,10-11H,6-9,12H2,1H3/b17-11-
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31.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288827
PNG
(US10092551, Example 136)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(C)nc1
Show InChI InChI=1S/C23H21N3O3S/c1-14-7-8-16(13-24-14)15(2)19-20(27)25-22(30-19)26-11-9-23(10-12-26)18-6-4-3-5-17(18)21(28)29-23/h3-8,13H,9-12H2,1-2H3/b19-15+
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31.6n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288809
PNG
(US10092551, Example 117)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cnc[nH]1
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50.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288782
PNG
(US10092551, Example 90)
Show SMILES O=C1N=C(S\C1=C/c1ccccn1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C21H19N3O2S/c25-19-18(13-16-6-3-4-10-22-16)27-20(23-19)24-11-8-21(9-12-24)17-7-2-1-5-15(17)14-26-21/h1-7,10,13H,8-9,11-12,14H2/b18-13-
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50.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288837
PNG
(US10092551, Example 146)
Show SMILES CC(C)(C)[Si](C)(C)OC\C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)c1ccc(Cl)nc1
Show InChI InChI=1S/C28H32ClN3O4SSi/c1-27(2,3)38(4,5)35-17-20(18-10-11-22(29)30-16-18)23-24(33)31-26(37-23)32-14-12-28(13-15-32)21-9-7-6-8-19(21)25(34)36-28/h6-11,16H,12-15,17H2,1-5H3/b23-20+
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50.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288798
PNG
(US10092551, Example 106)
Show SMILES C\C(=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1c(C)noc1C
Show InChI InChI=1S/C22H23N3O3S/c1-13(18-14(2)24-28-15(18)3)19-20(26)23-21(29-19)25-10-8-22(9-11-25)17-7-5-4-6-16(17)12-27-22/h4-7H,8-12H2,1-3H3/b19-13+
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50.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288817
PNG
(US10092551, Example 125)
Show SMILES O=C1N=C(SC1=C(C1CCCCC1)C1CCCCC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C28H36N2O2S/c31-26-25(24(20-9-3-1-4-10-20)21-11-5-2-6-12-21)33-27(29-26)30-17-15-28(16-18-30)23-14-8-7-13-22(23)19-32-28/h7-8,13-14,20-21H,1-6,9-12,15-19H2
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63.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288750
PNG
(US10092551, Example 58)
Show SMILES C\C(CO[Si](C)(C)C(C)(C)C)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H34N2O3SSi/c1-17(15-29-31(5,6)23(2,3)4)20-21(27)25-22(30-20)26-13-11-24(12-14-26)19-10-8-7-9-18(19)16-28-24/h7-10H,11-16H2,1-6H3/b20-17+
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63.1n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288786
PNG
(US10092551, Example 94)
Show SMILES O=C1N=C(S\C1=C/c1cccnc1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C21H19N3O2S/c25-19-18(12-15-4-3-9-22-13-15)27-20(23-19)24-10-7-21(8-11-24)17-6-2-1-5-16(17)14-26-21/h1-6,9,12-13H,7-8,10-11,14H2/b18-12-
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79.4n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288772
PNG
(US10092551, Example 80)
Show SMILES CC(C)(C)OC(=O)N1CCC\C(CC1)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C26H33N3O4S/c1-25(2,3)33-24(31)29-13-6-8-18(10-14-29)21-22(30)27-23(34-21)28-15-11-26(12-16-28)20-9-5-4-7-19(20)17-32-26/h4-5,7,9H,6,8,10-17H2,1-3H3/b21-18-
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79.4n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288857
PNG
(US10092551, Example 166)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ncccc21)c1ccc(C)nc1
Show InChI InChI=1S/C22H22N4O2S/c1-14-5-6-16(12-24-14)15(2)19-20(27)25-21(29-19)26-10-7-22(8-11-26)17-4-3-9-23-18(17)13-28-22/h3-6,9,12H,7-8,10-11,13H2,1-2H3/b19-15-
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79.4n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288792
PNG
(US10092551, Example 100)
Show SMILES Clc1ccc(cc1)C(=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H22Cl2N2O2S/c29-21-9-5-18(6-10-21)24(19-7-11-22(30)12-8-19)25-26(33)31-27(35-25)32-15-13-28(14-16-32)23-4-2-1-3-20(23)17-34-28/h1-12H,13-17H2
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79.4n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288787
PNG
(US10092551, Example 95)
Show SMILES O=C1N=C(S\C1=C/c1ccncc1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C21H19N3O2S/c25-19-18(13-15-5-9-22-10-6-15)27-20(23-19)24-11-7-21(8-12-24)17-4-2-1-3-16(17)14-26-21/h1-6,9-10,13H,7-8,11-12,14H2/b18-13-
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79.4n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288805
PNG
(US10092551, Example 113)
Show SMILES ClCC(CCl)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C18H18Cl2N2O2S/c19-9-13(10-20)15-16(23)21-17(25-15)22-7-5-18(6-8-22)14-4-2-1-3-12(14)11-24-18/h1-4H,5-11H2
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100n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288813
PNG
(US10092551, Example 121)
Show SMILES C\C(CS(C)(=O)=O)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C19H22N2O4S2/c1-13(12-27(2,23)24)16-17(22)20-18(26-16)21-9-7-19(8-10-21)15-6-4-3-5-14(15)11-25-19/h3-6H,7-12H2,1-2H3/b16-13-
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100n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288800
PNG
(US10092551, Example 108)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1cc2ncccc2o1
Show InChI InChI=1S/C24H21N3O3S/c1-15(20-13-18-19(30-20)7-4-10-25-18)21-22(28)26-23(31-21)27-11-8-24(9-12-27)17-6-3-2-5-16(17)14-29-24/h2-7,10,13H,8-9,11-12,14H2,1H3/b21-15-
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100n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288854
PNG
(US10092551, Example 163)
Show SMILES COCC(COC)=C1SC(=NC1=O)N1CCC2(CC1)OCc1ncccc21
Show InChI InChI=1S/C19H23N3O4S/c1-24-10-13(11-25-2)16-17(23)21-18(27-16)22-8-5-19(6-9-22)14-4-3-7-20-15(14)12-26-19/h3-4,7H,5-6,8-12H2,1-2H3
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100n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288773
PNG
(US10092551, Example 81)
Show SMILES Cl.O=C1N=C(S\C1=C1\CCCNCC1)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C21H25N3O2S.ClH/c25-19-18(15-5-3-10-22-11-7-15)27-20(23-19)24-12-8-21(9-13-24)17-6-2-1-4-16(17)14-26-21;/h1-2,4,6,22H,3,5,7-14H2;1H/b18-15-;
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126n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288855
PNG
(US10092551, Example 164)
Show SMILES COC1CCCC\C1=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ncccc21
Show InChI InChI=1S/C21H25N3O3S/c1-26-17-7-3-2-5-14(17)18-19(25)23-20(28-18)24-11-8-21(9-12-24)15-6-4-10-22-16(15)13-27-21/h4,6,10,17H,2-3,5,7-9,11-13H2,1H3/b18-14-
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126n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288702
PNG
(US10092551, Example 10)
Show SMILES Clc1ccc2\C(CCc2c1)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H21ClN2O2S/c25-17-6-8-18-15(13-17)5-7-19(18)21-22(28)26-23(30-21)27-11-9-24(10-12-27)20-4-2-1-3-16(20)14-29-24/h1-4,6,8,13H,5,7,9-12,14H2/b21-19-
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126n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288799
PNG
(US10092551, Example 107)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1ncc[nH]1
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158n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288839
PNG
(US10092551, Example 148)
Show SMILES CC(C)C(=C1/SC(=NC1=O)N1CCC2(CC1)OC(=O)c1ccccc21)\c1ccc(Cl)nc1
Show InChI InChI=1S/C24H22ClN3O3S/c1-14(2)19(15-7-8-18(25)26-13-15)20-21(29)27-23(32-20)28-11-9-24(10-12-28)17-6-4-3-5-16(17)22(30)31-24/h3-8,13-14H,9-12H2,1-2H3/b20-19+
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158n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288780
PNG
(US10092551, Example 88)
Show SMILES CC(C)(C)OC(=O)N1CCC\C(C1)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C25H31N3O4S/c1-24(2,3)32-23(30)28-12-6-8-17(15-28)20-21(29)26-22(33-20)27-13-10-25(11-14-27)19-9-5-4-7-18(19)16-31-25/h4-5,7,9H,6,8,10-16H2,1-3H3/b20-17-
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200n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288758
PNG
(US10092551, Example 66)
Show SMILES Cl.C\C(CN)=C1/SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C18H21N3O2S.ClH/c1-12(10-19)15-16(22)20-17(24-15)21-8-6-18(7-9-21)14-5-3-2-4-13(14)11-23-18;/h2-5H,6-11,19H2,1H3;1H/b15-12+;
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251n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288801
PNG
(US10092551, Example 109)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21)c1nc[nH]c1C
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251n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288858
PNG
(US10092551, Example 167)
Show SMILES C\C(=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ncccc21)c1oc(C)nc1C
Show InChI InChI=1S/C21H22N4O3S/c1-12(17-13(2)23-14(3)28-17)18-19(26)24-20(29-18)25-9-6-21(7-10-25)15-5-4-8-22-16(15)11-27-21/h4-5,8H,6-7,9-11H2,1-3H3/b18-12-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
316n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM288751
PNG
(US10092551, Example 59)
Show SMILES C\C(CO[Si](C)(C)C(C)(C)C)=C1\SC(=NC1=O)N1CCC2(CC1)OCc1ccccc21
Show InChI InChI=1S/C24H34N2O3SSi/c1-17(15-29-31(5,6)23(2,3)4)20-21(27)25-22(30-20)26-13-11-24(12-14-26)19-10-8-7-9-18(19)16-28-24/h7-10H,11-16H2,1-6H3/b20-17-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
316n/an/an/an/an/an/an/an/a



Hoffmann-LaRoche Inc.

US Patent


Assay Description
The human V1a receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to...


US Patent US10092551 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%