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Patent code US10092563

Compile Data Set for Download or QSAR

Found 408 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288879
PNG
(US10092563, Compound 14)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2[C@@H]2[C@H]3CNC[C@@H]23)c1C#N
Show InChI InChI=1S/C23H23ClN8O/c1-10-12(7-25)20(31-23(26)28-10)30-18(11-5-6-11)21-29-16-4-2-3-15(24)17(16)22(33)32(21)19-13-8-27-9-14(13)19/h2-4,11,13-14,18-19,27H,5-6,8-9H2,1H3,(H3,26,28,30,31)/t13-,14+,18-,19+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288879
PNG
(US10092563, Compound 14)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2[C@@H]2[C@H]3CNC[C@@H]23)c1C#N
Show InChI InChI=1S/C23H23ClN8O/c1-10-12(7-25)20(31-23(26)28-10)30-18(11-5-6-11)21-29-16-4-2-3-15(24)17(16)22(33)32(21)19-13-8-27-9-14(13)19/h2-4,11,13-14,18-19,27H,5-6,8-9H2,1H3,(H3,26,28,30,31)/t13-,14+,18-,19+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288880
PNG
(US10092563, Compound 15)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2[C@@H]2[C@H]3CNC[C@@H]23)n1
Show InChI InChI=1S/C22H22ClN9O/c23-13-2-1-3-14-15(13)21(33)32(17-11-7-27-8-12(11)17)20(28-14)16(9-4-5-9)29-19-10(6-24)18(25)30-22(26)31-19/h1-3,9,11-12,16-17,27H,4-5,7-8H2,(H5,25,26,29,30,31)/t11-,12+,16-,17+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288886
PNG
(US10092563, Compound 21)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H21ClFN9O/c1-10-12(9-23)17(29-20(24)27-10)26-11(2)18-28-16-14(22)4-3-13(21)15(16)19(32)31(18)30-7-5-25-6-8-30/h3-4,11,25H,5-8H2,1-2H3,(H3,24,26,27,29)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288872
PNG
(US10092563, Compound 7)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNC2(CC2)C1
Show InChI InChI=1S/C21H23ClN10O/c1-11(27-17-12(9-23)16(24)29-20(25)30-17)18-28-14-4-2-3-13(22)15(14)19(33)32(18)31-8-7-26-21(10-31)5-6-21/h2-4,11,26H,5-8,10H2,1H3,(H5,24,25,27,29,30)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288924
PNG
(US10092563, Compound 61)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNC(C1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF3N10O/c1-9(29-16-10(7-25)15(26)31-19(27)32-16)17-30-12-4-2-3-11(21)14(12)18(35)34(17)33-6-5-28-13(8-33)20(22,23)24/h2-4,9,13,28H,5-6,8H2,1H3,(H5,26,27,29,31,32)/t9-,13?/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288999
PNG
(US10092563, Compound 137 | US10092563, Compound 13...)
Show SMILES Nc1nc(N)c(C#N)c(NC2(CC2)c2nc3c(Cl)ccc(Cl)c3c(=O)n2C2CCC2)n1
Show InChI InChI=1S/C20H18Cl2N8O/c21-11-4-5-12(22)14-13(11)17(31)30(9-2-1-3-9)18(26-14)20(6-7-20)29-16-10(8-23)15(24)27-19(25)28-16/h4-5,9H,1-3,6-7H2,(H5,24,25,27,28,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288940
PNG
(US10092563, Compound 77)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)n1
Show InChI InChI=1S/C21H23ClN10O/c22-13-2-1-3-14-15(13)20(33)32(31-8-6-26-7-9-31)19(27-14)16(11-4-5-11)28-18-12(10-23)17(24)29-21(25)30-18/h1-3,11,16,26H,4-9H2,(H5,24,25,28,29,30)/t16-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288920
PNG
(US10092563, Compound 57)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H21ClN10O/c1-10(25-16-11(9-21)15(22)27-19(23)28-16)17-26-13-4-2-3-12(20)14(13)18(31)30(17)29-7-5-24-6-8-29/h2-4,10,24H,5-8H2,1H3,(H5,22,23,25,27,28)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288940
PNG
(US10092563, Compound 77)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)n1
Show InChI InChI=1S/C21H23ClN10O/c22-13-2-1-3-14-15(13)20(33)32(31-8-6-26-7-9-31)19(27-14)16(11-4-5-11)28-18-12(10-23)17(24)29-21(25)30-18/h1-3,11,16,26H,4-9H2,(H5,24,25,28,29,30)/t16-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288884
PNG
(US10092563, Compound 19)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C20H20ClN9O/c1-8(26-17-9(5-22)16(23)28-20(24)29-17)18-27-13-4-2-3-12(21)14(13)19(31)30(18)15-10-6-25-7-11(10)15/h2-4,8,10-11,15,25H,6-7H2,1H3,(H5,23,24,26,28,29)/t8-,10-,11+,15+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288918
PNG
(US10092563, Compound 55)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20ClN9O/c1-11(26-17-12(9-21)16(22)24-10-25-17)18-27-14-4-2-3-13(20)15(14)19(30)29(18)28-7-5-23-6-8-28/h2-4,10-11,23H,5-8H2,1H3,(H3,22,24,25,26)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288920
PNG
(US10092563, Compound 57)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H21ClN10O/c1-10(25-16-11(9-21)15(22)27-19(23)28-16)17-26-13-4-2-3-12(20)14(13)18(31)30(17)29-7-5-24-6-8-29/h2-4,10,24H,5-8H2,1H3,(H5,22,23,25,27,28)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288912
PNG
(US10092563, Compound 48)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(F)ccc(Cl)c3c(=O)n2N2CCNCC2)n1
Show InChI InChI=1S/C21H22ClFN10O/c22-12-3-4-13(23)16-14(12)20(34)33(32-7-5-27-6-8-32)19(29-16)15(10-1-2-10)28-18-11(9-24)17(25)30-21(26)31-18/h3-4,10,15,27H,1-2,5-8H2,(H5,25,26,28,30,31)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288992
PNG
(US10092563, Compound 130)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCC(N)C1
Show InChI InChI=1S/C19H20ClN9O/c1-10(26-17-12(7-21)16(23)24-9-25-17)18-27-14-4-2-3-13(20)15(14)19(30)29(18)28-6-5-11(22)8-28/h2-4,9-11H,5-6,8,22H2,1H3,(H3,23,24,25,26)/t10-,11?/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288909
PNG
(US10092563, Compound 44)
Show SMILES CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-3-15(27-18-13(11-23)12(2)26-21(24)29-18)19-28-16-6-4-5-14(22)17(16)20(32)31(19)30-9-7-25-8-10-30/h4-6,15,25H,3,7-10H2,1-2H3,(H3,24,26,27,29)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288931
PNG
(US10092563, Compound 68)
Show SMILES CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H23ClN10O/c1-2-13(26-17-11(10-22)16(23)28-20(24)29-17)18-27-14-5-3-4-12(21)15(14)19(32)31(18)30-8-6-25-7-9-30/h3-5,13,25H,2,6-9H2,1H3,(H5,23,24,26,28,29)/t13-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288910
PNG
(US10092563, Compound 46)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)c1C#N
Show InChI InChI=1S/C22H24ClN9O/c1-12-14(11-24)19(30-22(25)27-12)29-18(13-5-6-13)20-28-16-4-2-3-15(23)17(16)21(33)32(20)31-9-7-26-8-10-31/h2-4,13,18,26H,5-10H2,1H3,(H3,25,27,29,30)/t18-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288932
PNG
(US10092563, Compound 69)
Show SMILES C[C@H](Nc1ncnc2[nH]cc(Br)c12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288872
PNG
(US10092563, Compound 7)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNC2(CC2)C1
Show InChI InChI=1S/C21H23ClN10O/c1-11(27-17-12(9-23)16(24)29-20(25)30-17)18-28-14-4-2-3-13(22)15(14)19(33)32(18)31-8-7-26-21(10-31)5-6-21/h2-4,11,26H,5-8,10H2,1H3,(H5,24,25,27,29,30)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288909
PNG
(US10092563, Compound 44)
Show SMILES CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-3-15(27-18-13(11-23)12(2)26-21(24)29-18)19-28-16-6-4-5-14(22)17(16)20(32)31(19)30-9-7-25-8-10-30/h4-6,15,25H,3,7-10H2,1-2H3,(H3,24,26,27,29)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288913
PNG
(US10092563, Compound 49)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H18Cl2N8OS/c1-10(26-16-15-18(24-8-23-16)31-9-25-15)17-27-14-12(21)3-2-11(20)13(14)19(30)29(17)28-6-4-22-5-7-28/h2-3,8-10,22H,4-7H2,1H3,(H,23,24,26)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288939
PNG
(US10092563, Compound 76)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H19Cl2N9O/c1-10(27-17-11(8-22)16(23)25-9-26-17)18-28-15-13(21)3-2-12(20)14(15)19(31)30(18)29-6-4-24-5-7-29/h2-3,9-10,24H,4-7H2,1H3,(H3,23,25,26,27)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288984
PNG
(US10092563, Compound 121)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCOCC2)n1
Show InChI InChI=1S/C21H22ClN9O2/c22-13-2-1-3-14-15(13)20(32)31(30-6-8-33-9-7-30)19(26-14)16(11-4-5-11)27-18-12(10-23)17(24)28-21(25)29-18/h1-3,11,16H,4-9H2,(H5,24,25,27,28,29)/t16-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288873
PNG
(US10092563, Compound 8)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@H]1CCCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-11(27-18-13(10-23)17(24)29-21(25)30-18)19-28-15-6-2-5-14(22)16(15)20(32)31(19)12-4-3-8-26-9-7-12/h2,5-6,11-12,26H,3-4,7-9H2,1H3,(H5,24,25,27,29,30)/t11-,12-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288874
PNG
(US10092563, Compound 9)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1CCCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-11(27-18-13(10-23)17(24)29-21(25)30-18)19-28-15-6-2-5-14(22)16(15)20(32)31(19)12-4-3-8-26-9-7-12/h2,5-6,11-12,26H,3-4,7-9H2,1H3,(H5,24,25,27,29,30)/t11-,12+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288881
PNG
(US10092563, Compound 16)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1C1C2CNCC12
Show InChI InChI=1S/C21H20ClFN8O/c1-8-10(5-24)18(30-21(25)28-8)27-9(2)19-29-16-14(23)4-3-13(22)15(16)20(32)31(19)17-11-6-26-7-12(11)17/h3-4,9,11-12,17,26H,6-7H2,1-2H3,(H3,25,27,28,30)/t9-,11?,12?,17?/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288891
PNG
(US10092563, Compound 26)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-10(26-17-12(9-22)16(23)28-20(24)29-17)18-27-14-4-2-3-13(21)15(14)19(31)30(18)11-5-7-25-8-6-11/h2-4,10-11,25H,5-8H2,1H3,(H5,23,24,26,28,29)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288910
PNG
(US10092563, Compound 46)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)c1C#N
Show InChI InChI=1S/C22H24ClN9O/c1-12-14(11-24)19(30-22(25)27-12)29-18(13-5-6-13)20-28-16-4-2-3-15(23)17(16)21(33)32(20)31-9-7-26-8-10-31/h2-4,13,18,26H,5-10H2,1H3,(H3,25,27,29,30)/t18-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288917
PNG
(US10092563, Compound 54)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20ClFN10O/c1-9(26-16-10(8-22)15(23)28-19(24)29-16)17-27-14-12(21)3-2-11(20)13(14)18(32)31(17)30-6-4-25-5-7-30/h2-3,9,25H,4-7H2,1H3,(H5,23,24,26,28,29)/t9-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288926
PNG
(US10092563, Compound 63)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNC2(CC2)C1
Show InChI InChI=1S/C21H22ClN9O/c1-12(28-18-13(9-23)17(24)25-11-26-18)19-29-15-4-2-3-14(22)16(15)20(32)31(19)30-8-7-27-21(10-30)5-6-21/h2-4,11-12,27H,5-8,10H2,1H3,(H3,24,25,26,28)/t12-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288934
PNG
(US10092563, Compound 71)
Show SMILES C[C@H](Nc1ncnc2ccc(Cl)nc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H20Cl2N8O/c1-12(27-19-18-15(25-11-26-19)5-6-16(23)29-18)20-28-14-4-2-3-13(22)17(14)21(32)31(20)30-9-7-24-8-10-30/h2-6,11-12,24H,7-10H2,1H3,(H,25,26,27)/t12-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288880
PNG
(US10092563, Compound 15)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2[C@@H]2[C@H]3CNC[C@@H]23)n1
Show InChI InChI=1S/C22H22ClN9O/c23-13-2-1-3-14-15(13)21(33)32(17-11-7-27-8-12(11)17)20(28-14)16(9-4-5-9)29-19-10(6-24)18(25)30-22(26)31-19/h1-3,9,11-12,16-17,27H,4-5,7-8H2,(H5,25,26,29,30,31)/t11-,12+,16-,17+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM208901
PNG
(US10092563, Compound 58 | US9266878, 127a)
Show SMILES C[C@H](Nc1ncnc(N)c1C#Cc1ccc(F)cn1)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C25H23ClFN9O/c1-15(33-23-18(22(28)31-14-32-23)8-7-17-6-5-16(27)13-30-17)24-34-20-4-2-3-19(26)21(20)25(37)36(24)35-11-9-29-10-12-35/h2-6,13-15,29H,9-12H2,1H3,(H3,28,31,32,33)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288886
PNG
(US10092563, Compound 21)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H21ClFN9O/c1-10-12(9-23)17(29-20(24)27-10)26-11(2)18-28-16-14(22)4-3-13(21)15(16)19(32)31(18)30-7-5-25-6-8-30/h3-4,11,25H,5-8H2,1-2H3,(H3,24,26,27,29)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288941
PNG
(US10092563, Compound 78)
Show SMILES Clc1cccc2nc([C@@H](Nc3ncnc4scnc34)C3CC3)n(N3CCNCC3)c(=O)c12
Show InChI InChI=1S/C21H21ClN8OS/c22-13-2-1-3-14-15(13)21(31)30(29-8-6-23-7-9-29)19(27-14)16(12-4-5-12)28-18-17-20(25-10-24-18)32-11-26-17/h1-3,10-12,16,23H,4-9H2,(H,24,25,28)/t16-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288891
PNG
(US10092563, Compound 26)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-10(26-17-12(9-22)16(23)28-20(24)29-17)18-27-14-4-2-3-13(21)15(14)19(31)30(18)11-5-7-25-8-6-11/h2-4,10-11,25H,5-8H2,1H3,(H5,23,24,26,28,29)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288929
PNG
(US10092563, Compound 66 | US10092563, Compound 67)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-12(27-18-13(10-22)17(23)25-11-26-18)19-28-15-5-2-4-14(21)16(15)20(31)30(19)29-8-3-6-24-7-9-29/h2,4-5,11-12,24H,3,6-9H2,1H3,(H3,23,25,26,27)/t12-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288965
PNG
(US10092563, Compound 102)
Show SMILES Nc1ncnc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)c1C#N
Show InChI InChI=1S/C21H22ClN9O/c22-14-2-1-3-15-16(14)21(32)31(30-8-6-25-7-9-30)20(28-15)17(12-4-5-12)29-19-13(10-23)18(24)26-11-27-19/h1-3,11-12,17,25H,4-9H2,(H3,24,26,27,29)/t17-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288998
PNG
(US10092563, Compound 136)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@H]1CCOC1
Show InChI InChI=1S/C19H19ClN8O2/c1-9(24-16-11(7-21)15(22)26-19(23)27-16)17-25-13-4-2-3-12(20)14(13)18(29)28(17)10-5-6-30-8-10/h2-4,9-10H,5-6,8H2,1H3,(H5,22,23,24,26,27)/t9-,10-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288889
PNG
(US10092563, Compound 24)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C21H23ClN8O/c1-11-14(10-23)18(29-21(24)27-11)26-12(2)19-28-16-5-3-4-15(22)17(16)20(31)30(19)13-6-8-25-9-7-13/h3-5,12-13,25H,6-9H2,1-2H3,(H3,24,26,27,29)/t12-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288914
PNG
(US10092563, Compound 50)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H18ClFN8OS/c1-10(26-16-15-18(24-8-23-16)31-9-25-15)17-27-14-12(21)3-2-11(20)13(14)19(30)29(17)28-6-4-22-5-7-28/h2-3,8-10,22H,4-7H2,1H3,(H,23,24,26)/t10-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288947
PNG
(US10092563, Compound 84)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCCNCC1
Show InChI InChI=1S/C21H23ClN8O/c1-12(28-19-14(10-23)18(24)26-11-27-19)20-29-16-6-2-5-15(22)17(16)21(31)30(20)13-4-3-8-25-9-7-13/h2,5-6,11-13,25H,3-4,7-9H2,1H3,(H3,24,26,27,28)/t12-,13?/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288884
PNG
(US10092563, Compound 19)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C20H20ClN9O/c1-8(26-17-9(5-22)16(23)28-20(24)29-17)18-27-13-4-2-3-12(21)14(13)19(31)30(18)15-10-6-25-7-11(10)15/h2-4,8,10-11,15,25H,6-7H2,1H3,(H5,23,24,26,28,29)/t8-,10-,11+,15+/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288904
PNG
(US10092563, Compound 39)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(F)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20F2N10O/c1-9(26-16-10(8-22)15(23)28-19(24)29-16)17-27-14-12(21)3-2-11(20)13(14)18(32)31(17)30-6-4-25-5-7-30/h2-3,9,25H,4-7H2,1H3,(H5,23,24,26,28,29)/t9-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288912
PNG
(US10092563, Compound 48)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(F)ccc(Cl)c3c(=O)n2N2CCNCC2)n1
Show InChI InChI=1S/C21H22ClFN10O/c22-12-3-4-13(23)16-14(12)20(34)33(32-7-5-27-6-8-32)19(29-16)15(10-1-2-10)28-18-11(9-24)17(25)30-21(26)31-18/h3-4,10,15,27H,1-2,5-8H2,(H5,25,26,28,30,31)/t15-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288889
PNG
(US10092563, Compound 24)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C21H23ClN8O/c1-11-14(10-23)18(29-21(24)27-11)26-12(2)19-28-16-5-3-4-15(22)17(16)20(31)30(19)13-6-8-25-9-7-13/h3-5,12-13,25H,6-9H2,1-2H3,(H3,24,26,27,29)/t12-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288932
PNG
(US10092563, Compound 69)
Show SMILES C[C@H](Nc1ncnc2[nH]cc(Br)c12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM288933
PNG
(US10092563, Compound 70)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H19ClN8OS/c1-11(25-16-15-18(23-9-22-16)30-10-24-15)17-26-13-4-2-3-12(20)14(13)19(29)28(17)27-7-5-21-6-8-27/h2-4,9-11,21H,5-8H2,1H3,(H,22,23,25)/t11-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288934
PNG
(US10092563, Compound 71)
Show SMILES C[C@H](Nc1ncnc2ccc(Cl)nc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H20Cl2N8O/c1-12(27-19-18-15(25-11-26-19)5-6-16(23)29-18)20-28-14-4-2-3-13(22)17(14)21(32)31(20)30-9-7-24-8-10-30/h2-6,11-12,24H,7-10H2,1H3,(H,25,26,27)/t12-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 408 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%