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Patent code US10092570

Compile Data Set for Download or QSAR

Found 368 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261065
PNG
(3-{1-[4-Amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyra...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(-c3cc(O)cc(F)c3)c3c(N)ncnc23)c1OCC
Show InChI InChI=1S/C25H26ClFN6O3/c1-5-29-25(35)19-12(3)18(26)10-17(22(19)36-6-2)13(4)33-24-20(23(28)30-11-31-24)21(32-33)14-7-15(27)9-16(34)8-14/h7-11,13,34H,5-6H2,1-4H3,(H,29,35)(H2,28,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261083
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O/c1-11(7-24)29-8-15(9-29)18-12(2)17(23)6-16(20(18)31-5)14(4)30-22-19(13(3)28-30)21(25)26-10-27-22/h6,10-11,14-15H,8-9H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261091
PNG
(1-(1-{5-Chloro-3-[1-(2-fluoro-1- methylethyl)azeti...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)CF)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O/c1-11(7-24)29-8-15(9-29)18-12(2)17(23)6-16(20(18)31-5)14(4)30-22-19(13(3)28-30)21(25)26-10-27-22/h6,10-11,14-15H,7-9H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261094
PNG
(1-[1-(5-Chloro-2-methoxy-4-methyl-3-{1-[(1-methyl-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H27ClN8O2/c1-12-18(25)6-17(14(3)33-23-20(13(2)30-33)22(26)27-11-28-23)21(35-5)19(12)16-9-32(10-16)24(34)15-7-29-31(4)8-15/h6-8,11,14,16H,9-10H2,1-5H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261101
PNG
(1-(1-{5-Chloro-2-methoxy-4- methyl-3-[1-(1H-pyrazo...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cn[nH]c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H25ClN8O2/c1-11-17(24)5-16(13(3)32-22-19(12(2)30-32)21(25)26-10-27-22)20(34-4)18(11)15-8-31(9-15)23(33)14-6-28-29-7-14/h5-7,10,13,15H,8-9H2,1-4H3,(H,28,29)(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261102
PNG
(US10092570, Example 125 | US9707233, 125 | [3-(3-{...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(-c2cnn(C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN9O/c1-13-18(25)7-17(22(35-4)19(13)16-10-33(11-16)6-5-26)14(2)34-24-20(23(27)28-12-29-24)21(31-34)15-8-30-32(3)9-15/h7-9,12,14,16H,6,10-11H2,1-4H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289130
PNG
(US10092570, Example 131 | US10092570, Example 137)
Show SMILES COc1c(cc([N+]#[C-])c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O2/c1-11(33)7-31-8-14(9-31)17-12(2)16(27-4)6-15(20(17)34-5)13(3)32-23-18(19(30-32)21(24)25)22(26)28-10-29-23/h6,10-11,13-14,21,33H,7-9H2,1-3,5H3,(H2,26,28,29)/t11-,13?/m0/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261121
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O2/c1-4-31-19-14(7-15(22)18(23)17(19)13-8-28(9-13)5-6-30)12(3)29-21-16(11(2)27-29)20(24)25-10-26-21/h7,10,12-13,30H,4-6,8-9H2,1-3H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261123
PNG
(1-{1-[5-Chloro-2-ethoxy-3-(1- ethylazetidin-3-yl)-...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CC)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O/c1-5-28-8-13(9-28)17-18(23)15(22)7-14(19(17)30-6-2)12(4)29-21-16(11(3)27-29)20(24)25-10-26-21/h7,10,12-13H,5-6,8-9H2,1-4H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261132
PNG
(US10092570, Example 155 | US9707233, 155)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClF3N6O2/c1-4-34-19-13(5-14(23)17(24)15(19)12-7-31(8-12)6-10(2)33)11(3)32-22-16(18(30-32)20(25)26)21(27)28-9-29-22/h5,9-12,20,33H,4,6-8H2,1-3H3,(H2,27,28,29)/t10-,11?/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261137
PNG
((2S)-2-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)[C@@H](C)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H32ClN7O2/c1-12-18(25)8-17(14(3)32-23-20(13(2)29-32)22(26)27-11-28-23)21(34-7)19(12)16-9-31(10-16)15(4)24(33)30(5)6/h8,11,14-16H,9-10H2,1-7H3,(H2,26,27,28)/t14?,15-/m0/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261161
PNG
(2-[(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(NCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C23H28ClN7O2/c1-12-17(24)9-16(14(3)31-23-20(13(2)25)22(26)29-11-30-23)21(33-4)19(12)15-5-6-18(28-10-15)27-7-8-32/h5-6,9-11,14,25,32H,7-8H2,1-4H3,(H,27,28)(H3,26,29,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261192
PNG
(US10092570, Example 215 | US9707233, 215)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O/c1-6-32-21-16(14(5)31-23-19(13(4)29-31)22(26)27-11-28-23)7-18(24)17(8-25)20(21)15-9-30(10-15)12(2)3/h7,11-12,14-15H,6,9-10H2,1-5H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261193
PNG
(US10092570, Example 216 | US9707233, 216)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC(C)C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H30ClN7O/c1-6-33-22-17(15(5)32-24-20(14(4)30-32)23(27)28-12-29-24)7-19(25)18(8-26)21(22)16-10-31(11-16)9-13(2)3/h7,12-13,15-16H,6,9-11H2,1-5H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261194
PNG
(US10092570, Example 217 | US9707233, 217)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O/c1-4-33-22-17(14(3)32-24-20(13(2)30-32)23(27)28-12-29-24)7-19(25)18(8-26)21(22)16-10-31(11-16)9-15-5-6-15/h7,12,14-16H,4-6,9-11H2,1-3H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261235
PNG
(US10092570, Example 258 | US9707233, 258)
Show SMILES CCNC(=O)N1CC(C1)c1c(OCC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H27ClN8O2/c1-5-27-23(33)31-9-14(10-31)19-16(8-25)17(24)7-15(20(19)34-6-2)13(4)32-22-18(12(3)30-32)21(26)28-11-29-22/h7,11,13-14H,5-6,9-10H2,1-4H3,(H,27,33)(H2,26,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261254
PNG
(US10092570, Example 277 | US9707233, 277)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C1CCOCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O2/c1-13-20-23(27)28-12-29-24(20)32(30-13)14(2)17-8-19(25)18(9-26)21(22(17)33-3)15-10-31(11-15)16-4-6-34-7-5-16/h8,12,14-16H,4-7,10-11H2,1-3H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261264
PNG
(US10092570, Example 287 | US9707233, 287)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)S(=O)(=O)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O3S/c1-11(2)34(31,32)29-8-14(9-29)19-16(7-24)17(23)6-15(20(19)33-5)13(4)30-22-18(12(3)28-30)21(25)26-10-27-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289295
PNG
(US10092570, Example 296)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H25ClN8O2/c1-11-16-20(24)26-10-27-21(16)31(28-11)12(2)14-7-15(23)18(25-3)17(19(14)33-6)13-8-30(9-13)22(32)29(4)5/h7,10,12-13H,8-9H2,1-2,4-6H3,(H2,24,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261290
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN7O2/c1-6-35-22-16(14(3)33-24-20(13(2)32-33)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(4,5)34/h7-9,11-12,14,34H,6H2,1-5H3,(H2,28,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261298
PNG
(US10092570, Example 327 | US9707233, 327)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29N7O2/c1-5-32-21-17(15(4)30-23-19(14(3)28-30)22(25)26-12-27-23)8-13(2)18(9-24)20(21)16-10-29(11-16)6-7-31/h8,12,15-16,31H,5-7,10-11H2,1-4H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289321
PNG
(US10092570, Example 328)
Show SMILES COc1c(cc(C)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31N7O2/c1-13-7-17(15(3)31-23-19(14(2)29-31)22(26)27-12-28-23)21(33-6)20(18(13)8-25)16-9-30(10-16)11-24(4,5)32/h7,12,15-16,32H,9-11H2,1-6H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261303
PNG
(US10092570, Example 332 | US9707233, 332)
Show SMILES COc1c(cc(Cl)c(C#N)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H20ClN7O3S/c1-11-18-21(25)27-10-28-22(18)30(29-11)12(2)15-6-17(23)16(7-24)19(20(15)33-3)13-5-14(9-26-8-13)34(4,31)32/h5-6,8-10,12H,1-4H3,(H2,25,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261310
PNG
(US10092570, Example 339 | US9707233, 339)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)-c1ncco1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H21ClN8O2/c1-4-35-22-17(14(3)34-24-20(13(2)33-34)23(28)31-12-32-24)8-19(26)18(9-27)21(22)15-7-16(11-29-10-15)25-30-5-6-36-25/h5-8,10-12,14H,4H2,1-3H3,(H2,28,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255835
PNG
(5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6H2,1-5H3,(H2,28,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261339
PNG
(5-(3-{1-[4-Amino-5-oxo-6-(1H-pyrazol-4-yl)pyrid [2...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1cc(-c2cn[nH]c2)c(=O)c2c(N)ncnc12
Show InChI InChI=1S/C28H27ClN8O3/c1-14-20(29)8-18(25(40-5)22(14)16-6-7-21(31-9-16)28(39)36(3)4)15(2)37-12-19(17-10-34-35-11-17)24(38)23-26(30)32-13-33-27(23)37/h6-13,15H,1-5H3,(H,34,35)(H2,30,32,33)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255797
PNG
(1-{1-[3-(1-sec-butylazetidin-3-yl)-5-chloro-2-meth...)
Show SMILES CCC(C)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C23H31ClN6O/c1-7-12(2)29-9-16(10-29)19-13(3)18(24)8-17(21(19)31-6)15(5)30-23-20(14(4)28-30)22(25)26-11-27-23/h8,11-12,15-16H,7,9-10H2,1-6H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255798
PNG
(1-(1-{5-Chloro-2-methoxy-3-[1-(2-methoxyethyl)azet...)
Show SMILES COCCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C22H29ClN6O2/c1-12-17(23)8-16(20(31-5)18(12)15-9-28(10-15)6-7-30-4)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h8,11,14-15H,6-7,9-10H2,1-5H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255808
PNG
(4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)11-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-28-19(10-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255818
PNG
(5-{3-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C#N)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C23H19ClN6O2/c1-12-17(24)7-16(21(32-3)19(12)15-6-14(8-25)9-27-10-15)13(2)30-5-4-18(31)20-22(26)28-11-29-23(20)30/h4-7,9-11,13H,1-3H3,(H2,26,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255823
PNG
(3′-[1-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cccc(c1)S(=O)(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN5O4S/c1-14-19(26)12-18(15(2)31-10-9-20(32)22-24(27)28-13-29-25(22)31)23(35-5)21(14)16-7-6-8-17(11-16)36(33,34)30(3)4/h6-13,15H,1-5H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255839
PNG
(5-(3-{1-[4-amino-3-(1H-pyrazol-4-yl)-1H-pyrazolo[3...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cn[nH]c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H28ClN9O2/c1-6-39-24-18(9-19(28)14(2)21(24)16-7-8-20(30-10-16)27(38)36(4)5)15(3)37-26-22(25(29)31-13-32-26)23(35-37)17-11-33-34-12-17/h7-13,15H,6H2,1-5H3,(H,33,34)(H2,29,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255840
PNG
(5-(3-{1-[4-amino-3-(1-methyl-1H-pyrazol-4-yl)-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cnn(C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C28H30ClN9O2/c1-7-40-25-19(10-20(29)15(2)22(25)17-8-9-21(31-11-17)28(39)36(4)5)16(3)38-27-23(26(30)32-14-33-27)24(35-38)18-12-34-37(6)13-18/h8-14,16H,7H2,1-6H3,(H2,30,32,33)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289056
PNG
(US10092570, Example 57)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cncc(c2)C#N)c2c(N)ncnc12
Show InChI InChI=1S/C30H28ClN9O2/c1-6-42-27-21(10-22(31)16(2)24(27)19-7-8-23(35-14-19)30(41)39(4)5)17(3)40-29-25(28(33)36-15-37-29)26(38-40)20-9-18(11-32)12-34-13-20/h7-10,12-15,17H,6H2,1-5H3,(H2,33,36,37)
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US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255800
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255802
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261059
PNG
(5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClF2N7O2/c1-6-37-21-15(13(3)35-24-19(20(33-35)22(27)28)23(29)31-11-32-24)9-16(26)12(2)18(21)14-7-8-17(30-10-14)25(36)34(4)5/h7-11,13,22H,6H2,1-5H3,(H2,29,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261073
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H31ClN6O2/c1-6-32-21-17(15(5)30-23-20(14(4)28-30)22(25)26-11-27-23)7-18(24)13(3)19(21)16-9-29(10-16)8-12(2)31/h7,11-12,15-16,31H,6,8-10H2,1-5H3,(H2,25,26,27)/t12-,15?/m0/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261079
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H29ClN6O2/c1-11(30)7-28-8-15(9-28)18-12(2)17(23)6-16(20(18)31-5)14(4)29-22-19(13(3)27-29)21(24)25-10-26-22/h6,10-11,14-15,30H,7-9H2,1-5H3,(H2,24,25,26)/t11-,14?/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261085
PNG
(1-(1-{5-Chloro-2-methoxy-4-methyl-3-[1-(2,2,2-trif...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(F)(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClF3N6O/c1-10-15(22)5-14(12(3)31-20-17(11(2)29-31)19(26)27-9-28-20)18(32-4)16(10)13-6-30(7-13)8-21(23,24)25/h5,9,12-13H,6-8H2,1-4H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261087
PNG
((2R)-2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES CNC(=O)[C@@H](C)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C23H30ClN7O2/c1-11-17(24)7-16(13(3)31-22-19(12(2)29-31)21(25)27-10-28-22)20(33-6)18(11)15-8-30(9-15)14(4)23(32)26-5/h7,10,13-15H,8-9H2,1-6H3,(H,26,32)(H2,25,27,28)/t13?,14-/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261120
PNG
((2S)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O2/c1-5-32-20-15(13(4)30-22-17(12(3)28-30)21(25)26-10-27-22)6-16(23)19(24)18(20)14-8-29(9-14)7-11(2)31/h6,10-11,13-14,31H,5,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m0/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255844
PNG
(5-{3-[1-(4-amino-3-cyclopropyl-1H-pyrazolo[3,4-d]p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C2CC2)c2c(N)ncnc12
Show InChI InChI=1S/C27H30ClN7O2/c1-6-37-24-18(15(3)35-26-22(25(29)31-13-32-26)23(33-35)16-7-8-16)11-19(28)14(2)21(24)17-9-10-20(30-12-17)27(36)34(4)5/h9-13,15-16H,6-8H2,1-5H3,(H2,29,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261100
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29ClN6O3/c1-11-16(24)7-15(13(3)30-21-18(12(2)28-30)20(25)26-10-27-21)19(33-6)17(11)14-8-29(9-14)22(31)23(4,5)32/h7,10,13-14,32H,8-9H2,1-6H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261105
PNG
(5-{1-[4-amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O/c1-11(2)31-8-15(9-31)17-12(3)14(7-26)6-16(20(17)33-5)13(4)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h6,10-11,13,15,21H,8-9H2,1-5H3,(H2,27,28,29)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289137
PNG
(US10092570, Example 138)
Show SMILES COc1c(cc([N+]#[C-])c(C)c1C1CN(C1)C(C)=O)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H23F2N7O2/c1-10-15(26-4)6-14(19(33-5)16(10)13-7-30(8-13)12(3)32)11(2)31-22-17(18(29-31)20(23)24)21(25)27-9-28-22/h6,9,11,13,20H,7-8H2,1-3,5H3,(H2,25,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289138
PNG
(US10092570, Example 139)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O/c1-6-31-20-15(7-16(23)19(24)18(20)14-8-29(9-14)11(2)3)13(5)30-22-17(12(4)28-30)21(25)26-10-27-22/h7,10-11,13-14H,6,8-9H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261124
PNG
(1-(1-{5-Chloro-3-[1-(2,2- difluoroethyl)azetidin-3...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CC(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClF3N6O/c1-4-32-19-13(11(3)31-21-16(10(2)29-31)20(26)27-9-28-21)5-14(22)18(25)17(19)12-6-30(7-12)8-15(23)24/h5,9,11-12,15H,4,6-8H2,1-3H3,(H2,26,27,28)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261125
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CC(N)=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H25ClFN7O2/c1-4-32-19-13(11(3)30-21-16(10(2)28-30)20(25)26-9-27-21)5-14(22)18(23)17(19)12-6-29(7-12)8-15(24)31/h5,9,11-12H,4,6-8H2,1-3H3,(H2,24,31)(H2,25,26,27)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%