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Patent code US10092575

Compile Data Set for Download or QSAR

Found 221 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289549
PNG
(8-(2-Oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)-6-(...)
Show SMILES COc1ccc(Cn2c3sc(CN4CC5CC4CO5)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H21N5O3S/c1-28-15-4-2-13(3-5-15)8-25-20-18(19-22-12-23-26(19)21(25)27)7-17(30-20)10-24-9-16-6-14(24)11-29-16/h2-5,7,12,14,16H,6,8-11H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289553
PNG
(6-(4-Methoxybenzyl)-8-(1-methyl-3-(trifluoromethyl...)
Show SMILES COc1ccc(Cn2c3sc(cc3c3ncnn3c2=O)-c2cc(nn2C)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N6O2S/c1-27-14(8-16(26-27)20(21,22)23)15-7-13-17-24-10-25-29(17)19(30)28(18(13)32-15)9-11-3-5-12(31-2)6-4-11/h3-8,10H,9H2,1-2H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289557
PNG
(8-((Dimethylamino)methyl)-6-(4-methoxybenzyl)-9-me...)
Show SMILES COc1ccc(Cn2c3sc(CN(C)C)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C19H21N5O2S/c1-12-15(10-22(2)3)27-18-16(12)17-20-11-21-24(17)19(25)23(18)9-13-5-7-14(26-4)8-6-13/h5-8,11H,9-10H2,1-4H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289558
PNG
(8-((Cyclopropyl(methyl)amino)methyl)-6-(4-methoxyb...)
Show SMILES COc1ccc(Cn2c3sc(CN(C)C4CC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H23N5O2S/c1-13-17(11-24(2)15-6-7-15)29-20-18(13)19-22-12-23-26(19)21(27)25(20)10-14-4-8-16(28-3)9-5-14/h4-5,8-9,12,15H,6-7,10-11H2,1-3H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289560
PNG
(8-((Benzyl(2-hydroxyethyl)amino)methyl)-6-(4-metho...)
Show SMILES COc1ccc(Cn2c3sc(CN(CCO)Cc4ccccc4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C26H27N5O3S/c1-18-22(16-29(12-13-32)14-19-6-4-3-5-7-19)35-25-23(18)24-27-17-28-31(24)26(33)30(25)15-20-8-10-21(34-2)11-9-20/h3-11,17,32H,12-16H2,1-2H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289563
PNG
(8-((4-Acetylpiperazin-1-yl)methyl)-6-(4-methoxyben...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)C(C)=O)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H26N6O3S/c1-15-19(13-26-8-10-27(11-9-26)16(2)30)33-22-20(15)21-24-14-25-29(21)23(31)28(22)12-17-4-6-18(32-3)7-5-17/h4-7,14H,8-13H2,1-3H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289566
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((methyl((tetrahydr...)
Show SMILES COc1ccc(Cn2c3sc(CN(C)CC4CCCO4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H27N5O3S/c1-15-19(13-26(2)12-18-5-4-10-31-18)32-22-20(15)21-24-14-25-28(21)23(29)27(22)11-16-6-8-17(30-3)9-7-16/h6-9,14,18H,4-5,10-13H2,1-3H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289615
PNG
(6-(4-Chlorobenzyl)-9-(cyclopropylmethyl)-8,9,10,11...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CC5CC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H20ClN5OS/c22-15-5-3-14(4-6-15)10-26-20-18(19-23-12-24-27(19)21(26)28)16-7-8-25(9-13-1-2-13)11-17(16)29-20/h3-6,12-13H,1-2,7-11H2
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289624
PNG
(6-(4-Methoxybenzyl)-9-(3-(methylthio)propyl)-8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCCSC)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O2S2/c1-29-16-6-4-15(5-7-16)12-26-21-19(20-23-14-24-27(20)22(26)28)17-8-10-25(9-3-11-30-2)13-18(17)31-21/h4-7,14H,3,8-13H2,1-2H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289653
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C24H26FN5O3S/c1-32-17-3-2-16(19(25)10-17)12-29-23-21(22-26-14-27-30(22)24(29)31)18-4-7-28(13-20(18)34-23)11-15-5-8-33-9-6-15/h2-3,10,14-15H,4-9,11-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289654
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCCOC5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C24H26FN5O3S/c1-32-17-5-4-16(19(25)9-17)11-29-23-21(22-26-14-27-30(22)24(29)31)18-6-7-28(12-20(18)34-23)10-15-3-2-8-33-13-15/h4-5,9,14-15H,2-3,6-8,10-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289677
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-(tetrahydrofu...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC(F)(F)c4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H21F2N5O4S/c1-33-15-4-2-13(3-5-15)8-29-21-17(19-26-12-27-30(19)22(29)32)18-16(35-21)9-28(11-23(18,24)25)20(31)14-6-7-34-10-14/h2-5,12,14H,6-11H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289686
PNG
(6-(4-Methoxybenzyl)-8-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4N(CCCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-6-4-14(5-7-16)11-27-22-18(19-24-13-25-28(19)23(27)30)17-3-2-9-26(21(17)33-22)20(29)15-8-10-32-12-15/h4-7,13,15H,2-3,8-12H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289697
PNG
(8-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6-(4-...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)c4ccccc4F)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C26H25FN6O2S/c1-35-19-8-6-18(7-9-19)15-32-25-21(24-28-17-29-33(24)26(32)34)14-20(36-25)16-30-10-12-31(13-11-30)23-5-3-2-4-22(23)27/h2-9,14,17H,10-13,15-16H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289702
PNG
(6-(4-Methoxybenzyl)-8-(4-morpholinopiperidin-1-yl)...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCC(CC4)N4CCOCC4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H30N6O3S/c1-33-20-4-2-18(3-5-20)15-30-24-22(23-26-17-27-31(23)25(30)32)14-21(35-24)16-28-8-6-19(7-9-28)29-10-12-34-13-11-29/h2-5,14,17,19H,6-13,15-16H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289713
PNG
(8-(((2R,6S)-2,6-Dimethylmorpholino)methyl)-6-(2-fl...)
Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C22H24FN5O3S/c1-13-8-26(9-14(2)31-13)11-17-7-18-20-24-12-25-28(20)22(29)27(21(18)32-17)10-15-4-5-16(30-3)6-19(15)23/h4-7,12-14H,8-11H2,1-3H3/t13-,14+
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289716
PNG
(6-(3-Chloro-4-fluorobenzyl)-8-(((2R,6S)-2,6-dimeth...)
Show SMILES C[C@H]1CN(Cc2cc3c(s2)n(Cc2ccc(F)c(Cl)c2)c(=O)n2ncnc32)C[C@@H](C)O1
Show InChI InChI=1S/C21H21ClFN5O2S/c1-12-7-26(8-13(2)30-12)10-15-6-16-19-24-11-25-28(19)21(29)27(20(16)31-15)9-14-3-4-18(23)17(22)5-14/h3-6,11-13H,7-10H2,1-2H3/t12-,13+
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289519
PNG
(8-benzyl-6-(2-Chlorobenzyl)thieno[3,2-e][1,2,4]tri...)
Show SMILES Clc1ccccc1Cn1c2sc(Cc3ccccc3)cc2c2ncnn2c1=O
Show InChI InChI=1S/C21H15ClN4OS/c22-18-9-5-4-8-15(18)12-25-20-17(19-23-13-24-26(19)21(25)27)11-16(28-20)10-14-6-2-1-3-7-14/h1-9,11,13H,10,12H2
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289522
PNG
(6-(3-Chlorobenzyl)-9-methylthieno[3,2-e][1,2,4]tri...)
Show SMILES Cc1csc2n(Cc3cccc(Cl)c3)c(=O)n3ncnc3c12
Show InChI InChI=1S/C15H11ClN4OS/c1-9-7-22-14-12(9)13-17-8-18-20(13)15(21)19(14)6-10-3-2-4-11(16)5-10/h2-5,7-8H,6H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289537
PNG
(6-Benzyl-8-isopentylthieno[3,2-e][1,2,4]triazolo[1...)
Show SMILES CC(C)CCc1cc2c3ncnn3c(=O)n(Cc3ccccc3)c2s1
Show InChI InChI=1S/C19H20N4OS/c1-13(2)8-9-15-10-16-17-20-12-21-23(17)19(24)22(18(16)25-15)11-14-6-4-3-5-7-14/h3-7,10,12-13H,8-9,11H2,1-2H3
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289561
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-(piperazin-1-ylmeth...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCNCC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H24N6O2S/c1-14-17(12-25-9-7-22-8-10-25)30-20-18(14)19-23-13-24-27(19)21(28)26(20)11-15-3-5-16(29-2)6-4-15/h3-6,13,22H,7-12H2,1-2H3
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289584
PNG
(8-(((3R,5S)-3,5-Dimethylpiperazin-1-yl)methyl)-6-(...)
Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)N[C@H](C)C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H28N6O2S/c1-14-9-27(10-15(2)26-14)12-19-16(3)20-21-24-13-25-29(21)23(30)28(22(20)32-19)11-17-5-7-18(31-4)8-6-17/h5-8,13-15,26H,9-12H2,1-4H3/t14-,15+
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289590
PNG
(9-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-6-(4-me...)
Show SMILES COc1ccc(Cn2c3scc(CN4C[C@H](C)O[C@H](C)C4)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O3S/c1-14-8-25(9-15(2)30-14)11-17-12-31-21-19(17)20-23-13-24-27(20)22(28)26(21)10-16-4-6-18(29-3)7-5-16/h4-7,12-15H,8-11H2,1-3H3/t14-,15+
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289591
PNG
(6-(4-Chlorobenzyl)-8,9-dimethylfuro[3,2-e][1,2,4]t...)
Show SMILES Cc1oc2n(Cc3ccc(Cl)cc3)c(=O)n3ncnc3c2c1C
Show InChI InChI=1S/C16H13ClN4O2/c1-9-10(2)23-15-13(9)14-18-8-19-21(14)16(22)20(15)7-11-3-5-12(17)6-4-11/h3-6,8H,7H2,1-2H3
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289614
PNG
(6-(4-Chlorobenzyl)-9-benzyl-8,9,10,11-tetrahydropy...)
Show SMILES Clc1ccc(Cn2c3sc4CN(Cc5ccccc5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H20ClN5OS/c25-18-8-6-17(7-9-18)13-29-23-21(22-26-15-27-30(22)24(29)31)19-10-11-28(14-20(19)32-23)12-16-4-2-1-3-5-16/h1-9,15H,10-14H2
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289616
PNG
(2-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-4-(4-me...)
Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ccnn3c2=O)cc1
Show InChI InChI=1S/C23H26N4O3S/c1-15-11-25(12-16(2)30-15)14-19-10-20-21-8-9-24-27(21)23(28)26(22(20)31-19)13-17-4-6-18(29-3)7-5-17/h4-10,15-16H,11-14H2,1-3H3/t15-,16+
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289692
PNG
(6-(4-Methoxybenzyl)-9-(pyrrolidine-3-carbonyl)-8,9...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCNC2)cc1
Show InChI InChI=1S/C23H24N6O3S/c1-32-16-4-2-14(3-5-16)11-28-22-19(20-25-13-26-29(20)23(28)31)17-7-9-27(12-18(17)33-22)21(30)15-6-8-24-10-15/h2-5,13,15,24H,6-12H2,1H3
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289694
PNG
(6-(4-Methoxybenzyl)-8,9,10,11-tetrahydropyrido[4',...)
Show SMILES COc1ccc(Cn2c3sc4CNCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C18H17N5O2S/c1-25-12-4-2-11(3-5-12)9-22-17-15(13-6-7-19-8-14(13)26-17)16-20-10-21-23(16)18(22)24/h2-5,10,19H,6-9H2,1H3
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289721
PNG
(6-(2,3-Difluoro-4-methoxybenzyl)-8-((methyl((3-met...)
Show SMILES COc1ccc(Cn2c3sc(CN(C)CC4(C)COC4)cc3c3ncnn3c2=O)c(F)c1F
Show InChI InChI=1S/C22H23F2N5O3S/c1-22(10-32-11-22)9-27(2)8-14-6-15-19-25-12-26-29(19)21(30)28(20(15)33-14)7-13-4-5-16(31-3)18(24)17(13)23/h4-6,12H,7-11H2,1-3H3
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n/an/an/an/a 550n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289512
PNG
(6-(2-Chlorobenzyl)thieno[3,2-e][1,2,4]triazolo[1,5...)
Show SMILES Clc1ccccc1Cn1c2sccc2c2ncnn2c1=O
Show InChI InChI=1S/C14H9ClN4OS/c15-11-4-2-1-3-9(11)7-18-13-10(5-6-21-13)12-16-8-17-19(12)14(18)20/h1-6,8H,7H2
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n/an/an/an/a 5.50E+3n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289536
PNG
(6-Benzylthieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimid...)
Show SMILES O=c1n(Cc2ccccc2)c2sccc2c2ncnn12
Show InChI InChI=1S/C14H10N4OS/c19-14-17(8-10-4-2-1-3-5-10)13-11(6-7-20-13)12-15-9-16-18(12)14/h1-7,9H,8H2
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n/an/an/an/a 5.50E+3n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289598
PNG
(6-([1,1'-Biphenyl]-4-ylmethyl)-8,9,10,11-tetrahydr...)
Show SMILES O=c1n(Cc2ccc(cc2)-c2ccccc2)c2sc3CCCCc3c2c2ncnn12
Show InChI InChI=1S/C24H20N4OS/c29-24-27(14-16-10-12-18(13-11-16)17-6-2-1-3-7-17)23-21(22-25-15-26-28(22)24)19-8-4-5-9-20(19)30-23/h1-3,6-7,10-13,15H,4-5,8-9,14H2
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n/an/an/an/a 5.50E+3n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289612
PNG
(6-(3,4-Dimethoxybenzyl)-8,9,10,11-tetrahydropyrido...)
Show SMILES COc1ccc(Cn2c3sc4NCCCc4c3c3ncnn3c2=O)cc1OC
Show InChI InChI=1S/C19H19N5O3S/c1-26-13-6-5-11(8-14(13)27-2)9-23-18-15(12-4-3-7-20-17(12)28-18)16-21-10-22-24(16)19(23)25/h5-6,8,10,20H,3-4,7,9H2,1-2H3
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n/an/an/an/a 5.50E+3n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289666
PNG
(8-(3-Chlorobenzyl)-6-(3,4-dimethoxybenzyl)-8,9,10,...)
Show SMILES COc1ccc(Cn2c3sc4N(Cc5cccc(Cl)c5)CCCc4c3c3ncnn3c2=O)cc1OC
Show InChI InChI=1S/C26H24ClN5O3S/c1-34-20-9-8-17(12-21(20)35-2)14-31-25-22(23-28-15-29-32(23)26(31)33)19-7-4-10-30(24(19)36-25)13-16-5-3-6-18(27)11-16/h3,5-6,8-9,11-12,15H,4,7,10,13-14H2,1-2H3
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n/an/an/an/a 5.50E+3n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289689
PNG
(8-(4-Chlorobenzoyl)-6-(3,4-dimethoxybenzyl)-8,9,10...)
Show SMILES COc1ccc(Cn2c3sc4N(CCCc4c3c3ncnn3c2=O)C(=O)c2ccc(Cl)cc2)cc1OC
Show InChI InChI=1S/C26H22ClN5O4S/c1-35-19-10-5-15(12-20(19)36-2)13-31-25-21(22-28-14-29-32(22)26(31)34)18-4-3-11-30(24(18)37-25)23(33)16-6-8-17(27)9-7-16/h5-10,12,14H,3-4,11,13H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289550
PNG
(8-(7-Oxa-2-azaspiro[3.5]nonan-2-ylmethyl)-6-(4-met...)
Show SMILES COc1ccc(Cn2c3sc(CN4CC5(C4)CCOCC5)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H25N5O3S/c1-30-17-4-2-16(3-5-17)11-27-21-19(20-24-15-25-28(20)22(27)29)10-18(32-21)12-26-13-23(14-26)6-8-31-9-7-23/h2-5,10,15H,6-9,11-14H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289567
PNG
(8-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-6-(4-me...)
Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)O[C@H](C)C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H27N5O3S/c1-14-9-26(10-15(2)31-14)12-19-16(3)20-21-24-13-25-28(21)23(29)27(22(20)32-19)11-17-5-7-18(30-4)8-6-17/h5-8,13-15H,9-12H2,1-4H3/t14-,15+
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289576
PNG
(8-((4-Isopropylpiperazin-1-yl)methyl)-6-(4-methoxy...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)C(C)C)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H30N6O2S/c1-16(2)28-11-9-27(10-12-28)14-20-17(3)21-22-25-15-26-30(22)24(31)29(23(21)33-20)13-18-5-7-19(32-4)8-6-18/h5-8,15-16H,9-14H2,1-4H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289578
PNG
(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Show SMILES CCN1CCN(Cc2sc3n(Cc4ccc(OC)cc4)c(=O)n4ncnc4c3c2C)CC1=O
Show InChI InChI=1S/C23H26N6O3S/c1-4-27-10-9-26(13-19(27)30)12-18-15(2)20-21-24-14-25-29(21)23(31)28(22(20)33-18)11-16-5-7-17(32-3)8-6-16/h5-8,14H,4,9-13H2,1-3H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289618
PNG
(6-(4-Chlorobenzyl)-9-(oxetan-3-yl)-8,9,10,11-tetra...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C2COC2)cc1
Show InChI InChI=1S/C20H18ClN5O2S/c21-13-3-1-12(2-4-13)7-25-19-17(18-22-11-23-26(18)20(25)27)15-5-6-24(8-16(15)29-19)14-9-28-10-14/h1-4,11,14H,5-10H2
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289641
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydro-2H-pyra...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CC4CCOCC4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C23H23ClFN5O2S/c24-16-2-1-15(18(25)9-16)11-29-22-20(21-26-13-27-30(21)23(29)31)17-3-6-28(12-19(17)33-22)10-14-4-7-32-8-5-14/h1-2,9,13-14H,3-8,10-12H2
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289645
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydrofuran-3-...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CC4CCOC4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C22H21ClFN5O2S/c23-15-2-1-14(17(24)7-15)9-28-21-19(20-25-12-26-29(20)22(28)30)16-3-5-27(10-18(16)32-21)8-13-4-6-31-11-13/h1-2,7,12-13H,3-6,8-11H2
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289647
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CC(F)(F)c4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25F2N5O3S/c1-33-17-4-2-15(3-5-17)11-30-22-19(21-27-14-28-31(21)23(30)32)20-18(35-22)12-29(13-24(20,25)26)10-16-6-8-34-9-7-16/h2-5,14,16H,6-13H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289648
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCCOC5)CC(F)(F)c4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25F2N5O3S/c1-33-17-6-4-15(5-7-17)10-30-22-19(21-27-14-28-31(21)23(30)32)20-18(35-22)11-29(13-24(20,25)26)9-16-3-2-8-34-12-16/h4-7,14,16H,2-3,8-13H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289660
PNG
(6-(4-Methoxybenzyl)-8-((tetrahydro-2H-pyran-4-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4N(CC5CCOCC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-6-4-16(5-7-18)14-28-23-20(21-25-15-26-29(21)24(28)30)19-3-2-10-27(22(19)33-23)13-17-8-11-32-12-9-17/h4-7,15,17H,2-3,8-14H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289661
PNG
(6-(4-Methoxybenzyl)-8-((tetrahydro-2H-pyran-3-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4N(CC5CCCOC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-8-6-16(7-9-18)13-28-23-20(21-25-15-26-29(21)24(28)30)19-5-2-10-27(22(19)33-23)12-17-4-3-11-32-14-17/h6-9,15,17H,2-5,10-14H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289662
PNG
(6-(4-Methoxybenzyl)-8-((tetrahydrofuran-3-yl)methy...)
Show SMILES COc1ccc(Cn2c3sc4N(CC5CCOC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H25N5O3S/c1-30-17-6-4-15(5-7-17)12-27-22-19(20-24-14-25-28(20)23(27)29)18-3-2-9-26(21(18)32-22)11-16-8-10-31-13-16/h4-7,14,16H,2-3,8-13H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289669
PNG
(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CC2)cc1
Show InChI InChI=1S/C21H18ClN5O2S/c22-14-5-1-12(2-6-14)9-26-20-17(18-23-11-24-27(18)21(26)29)15-7-8-25(10-16(15)30-20)19(28)13-3-4-13/h1-2,5-6,11,13H,3-4,7-10H2
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289672
PNG
(6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-4-2-14(3-5-16)10-27-22-19(20-24-13-25-28(20)23(27)30)17-6-8-26(11-18(17)33-22)21(29)15-7-9-32-12-15/h2-5,13,15H,6-12H2,1H3
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n/an/an/an/a<100n/an/an/a25



Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289672
PNG
(6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-4-2-14(3-5-16)10-27-22-19(20-24-13-25-28(20)23(27)30)17-6-8-26(11-18(17)33-22)21(29)15-7-9-32-12-15/h2-5,13,15H,6-12H2,1H3
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Dart NeuroScience (Cayman) Ltd.

US Patent


Assay Description
The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...


US Patent US10092575 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%