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Patent code US10093635

Compile Data Set for Download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoglyceride lipase


(Homo sapiens (human))
BDBM38015
PNG
(2-(2-fluoro-6-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC(O)=O)c1F
Show InChI InChI=1S/C14H13ClFNO3/c15-11-7-8(5-6-12(11)16)17-13(18)9-3-1-2-4-10(9)14(19)20/h5-7H,1-4H2,(H,17,18)(H,19,20)
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n/an/a 550n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37978
PNG
(1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-fluoro- 4-m...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC(=O)NS(C)(=O)=O)c1F
Show InChI InChI=1S/C26H28ClN7O/c1-19-6-9-21(27)17-24(19)32-13-15-33(16-14-32)25(23-5-3-4-12-28-23)26-29-30-31-34(26)18-20-7-10-22(35-2)11-8-20/h3-12,17,25H,13-16,18H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37985
PNG
(1-((2-((4-(((1,1,1,3,3,3-hexafluoropropan-2- yl)ox...)
Show SMILES OC(=O)C1(COc2cc(ccc2CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F)CC1
Show InChI InChI=1S/C15H14N4O3S/c1-2-22-12(21)7-9(20)8-23-15-17-14-13(18-19-15)10-5-3-4-6-11(10)16-14/h3-6H,2,7-8H2,1H3,(H,16,17,19)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37957
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-((4-(1- ((e...)
Show SMILES CCOC(=O)OC(C)OC(=O)CCCNc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H21N5O5S/c1-2-27-17(26)12-10-20-18(21-15(12)19)29-11-14(24)22-5-7-23(8-6-22)16(25)13-4-3-9-28-13/h3-4,9-10H,2,5-8,11H2,1H3,(H2,19,20,21)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37998
PNG
(1-((4-fluoro-2-((4-(((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES Cc1cc(F)cc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c1OCC1(CC1)C(O)=O
Show InChI InChI=1S/C17H25N3O3/c21-17(13-18-12-14-4-3-9-23-14)19-15-5-1-2-6-16(15)20-7-10-22-11-8-20/h1-2,5-6,14,18H,3-4,7-13H2,(H,19,21)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38003
PNG
(1-((5-cyano-2-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES OC(=O)C1(COc2cc(ccc2CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C#N)CCCC1
Show InChI InChI=1S/C23H30FN3O6S/c1-16(2)22(23(29)25-13-18-5-3-11-32-18)27(15-19-6-4-12-33-19)21(28)14-26-34(30,31)20-9-7-17(24)8-10-20/h4,6-10,12,16,18,22,26H,3,5,11,13-15H2,1-2H3,(H,25,29)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38004
PNG
((1s,3s)-3-(2-((4-(((1,1,1,3,3,3- hexafluoropropan-...)
Show SMILES OC(=O)[C@@H]1C[C@@H](C1)Oc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H21N7/c1-6-14-9-15-10(18-12(3,4)5)17-11(16-9)19(7-2)8-13/h6-7H2,1-5H3,(H2,14,15,16,17,18)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38010
PNG
(2-(2-chloro-6-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC(O)=O)c1Cl
Show InChI InChI=1S/C24H26N2O7S/c1-31-18-10-9-16-12-17(23(27)25-21(16)13-18)14-26(15-19-6-5-11-33-19)34(29,30)22-8-4-3-7-20(22)24(28)32-2/h3-4,7-10,12-13,19H,5-6,11,14-15H2,1-2H3,(H,25,27)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37960
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-((4-(1- ((i...)
Show SMILES CC(C)OC(=O)OC(C)OC(=O)CCCNc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H23FN6S/c1-2-24-9-11-25(12-10-24)18(15-5-7-16(20)8-6-15)19-21-22-23-26(19)14-17-4-3-13-27-17/h3-8,13,18H,2,9-12,14H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38006
PNG
((1R,3R)-3-(2-((4-(((1,1,1,3,3,3- hexafluoropropan-...)
Show SMILES OC(=O)[C@@H]1CC[C@H](C1)Oc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H30N6O3/c1-2-35-21-9-10-24-20(14-21)15-23(27(34)28-24)25(32-12-11-18-6-3-4-7-19(18)16-32)26-29-30-31-33(26)17-22-8-5-13-36-22/h3-4,6-7,9-10,14-15,22,25H,2,5,8,11-13,16-17H2,1H3,(H,28,34)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38009
PNG
(4-(3-((4-(((1,1,1,3,3,3-hexafluoropropan-2- yl)oxy...)
Show SMILES CC(C)(C#Cc1cc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cc(c1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C23H30N4O3/c1-3-7-22(28)24-18-8-6-9-19(16-18)25-23(29)17-26-12-14-27(15-13-26)20-10-4-5-11-21(20)30-2/h4-6,8-11,16H,3,7,12-15,17H2,1-2H3,(H,24,28)(H,25,29)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38011
PNG
(1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-chloro- 4-m...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC(=O)NS(C)(=O)=O)c1Cl
Show InChI InChI=1S/C22H29N3O5/c1-28-15-9-5-8-14(10-15)21(26)24-25-20(13-6-4-7-13)23-17-12-19(30-3)18(29-2)11-16(17)22(25)27/h11-15H,4-10H2,1-3H3,(H,24,26)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37967
PNG
(2-(5-Chloro-2-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES OC(=O)COc1cc(Cl)ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H29N5O5/c1-18-8-13-23(36-18)25(26(33)27-14-15-34-2)30(16-19-9-11-20(35-3)12-10-19)24(32)17-31-22-7-5-4-6-21(22)28-29-31/h4-13,25H,14-17H2,1-3H3,(H,27,33)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37974
PNG
(2-(3-((4-(((1,1,1,3,3,3-hexafluoropropan-2- yl)oxy...)
Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2cc(COC=O)cc(c2)C(F)(F)F)CC1)C(F)(F)F
Show InChI InChI=1S/C18H20N4O4S/c1-13-15(4-8-25-13)17-19-20-18(22(17)11-14-3-2-7-26-14)27-12-16(23)21-5-9-24-10-6-21/h2-4,7-8H,5-6,9-12H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37976
PNG
(1-(3-((4-(((1,1,1,3,3,3-hexafluoropropan-2- yl)oxy...)
Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2cc(OC3(CC3)OC=O)cc(c2)C(F)(F)F)CC1)C(F)(F)F
Show InChI InChI=1S/C23H28N6O3/c1-17-6-8-18(9-7-17)21(22-24-25-26-29(22)16-19-4-2-14-31-19)27-10-12-28(13-11-27)23(30)20-5-3-15-32-20/h3,5-9,15,19,21H,2,4,10-14,16H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37983
PNG
(4-(2-Fluoro-6-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES CC(C)(C#Cc1c(F)cccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C17H19N3O2S/c1-10-9-23-17(19-10)18-8-15(21)16-11(2)20(3)14-6-5-12(22-4)7-13(14)16/h5-7,9H,8H2,1-4H3,(H,18,19)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37986
PNG
(1-((3-((4-(((1,1,1,3,3,3-hexafluoropropan-2- yl)ox...)
Show SMILES OC(=O)C1(COc2cc(CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C13H10N6OS/c1-19(12(20)10-8-15-5-6-16-10)13-18-17-11(21-13)9-3-2-4-14-7-9/h2-8H,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38012
PNG
(1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-chloro- 2-(...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC(=O)NS(=O)(=O)C2CC2)c1Cl
Show InChI InChI=1S/C21H25NO5/c1-22-7-6-14-9-19-20(27-12-26-19)10-15(14)17(23)8-13-4-5-18(24-2)21(25-3)16(13)11-22/h4-5,9-10,17,23H,6-8,11-12H2,1-3H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38018
PNG
(4-(2-chloro-6-((4- (((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES CC(C)(C#Cc1c(Cl)cccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C23H24N2O4/c1-13-11-12-19(29-13)22-20(14(2)24-16-8-6-9-17(26)21(16)22)23(27)25-15-7-4-5-10-18(15)28-3/h4-5,7,10-12,21-22H,6,8-9H2,1-3H3,(H,25,27)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37980
PNG
(1-(2-((4-(((1,1,1,3,3,3-Hexafluoropropan-2- yl)oxy...)
Show SMILES OC(=O)C1(CC1)Oc1c(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cccc1C(F)(F)F
Show InChI InChI=1S/C16H24N2O4S2/c1-3-5-11-23(19,20)16(24(21,22)12-6-4-2)15-17-13-9-7-8-10-14(13)18-15/h7-10,16H,3-6,11-12H2,1-2H3,(H,17,18)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37981
PNG
(1-((2-Chloro-6-((4-(((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC2(CC2)C(O)=O)c1Cl
Show InChI InChI=1S/C15H11N3O/c19-15(14-10-16-8-9-17-14)18-13-7-3-5-11-4-1-2-6-12(11)13/h1-10H,(H,18,19)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37982
PNG
(4-(2-Fluoro-6-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(C#CC(C)(C)C(O)=O)c1F
Show InChI InChI=1S/C22H26N2O3/c1-15-8-6-7-9-18(15)24-19(25)14-23(22(2,3)4)21(26)20(24)16-10-12-17(27-5)13-11-16/h6-13,20H,14H2,1-5H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37992
PNG
(1-((2,3-difluoro-6-((4-(((1,1,1,3,3,3- hexafluorop...)
Show SMILES OC(=O)C1(COc2c(CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)ccc(F)c2F)CC1
Show InChI InChI=1S/C20H27NO6/c1-11(2)26-18(23)16-14(22)9-20(5,25)17(19(24)27-12(3)4)15(16)13-7-6-8-21-10-13/h6-8,10-12,15-17,25H,9H2,1-5H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37996
PNG
(1-((2,3-difluoro-6-((4-(((1,1,1,3,3,3- hexafluorop...)
Show SMILES OC(=O)C1(COc2c(CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)ccc(F)c2F)CCCC1
Show InChI InChI=1S/C17H16N2O2S/c1-2-16(20)19(11-14-9-6-10-21-14)17-18-15(12-22-17)13-7-4-3-5-8-13/h3-10,12H,2,11H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37997
PNG
(1-((3-fluoro-6-((4-(((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES Cc1c(F)ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c1OCC1(CC1)C(O)=O
Show InChI InChI=1S/C23H28ClN7/c24-20-7-5-19(6-8-20)22(23-26-27-28-31(23)21-3-1-2-4-21)30-15-13-29(14-16-30)17-18-9-11-25-12-10-18/h5-12,21-22H,1-4,13-17H2
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37966
PNG
(N-(2-((5-Chloro-2-((4-(((1,1,1,3,3,3- hexafluoropr...)
Show SMILES CN(CCNc1cc(Cl)ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)CC(O)=O
Show InChI InChI=1S/C19H26N4O2S/c1-3-23-17(13-25-16-10-6-5-9-15(16)2)20-21-19(23)26-14-18(24)22-11-7-4-8-12-22/h5-6,9-10H,3-4,7-8,11-14H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37965
PNG
(2-(2-((2-Fluoro-6-((4-(((1,1,1,3,3,3- hexafluoropr...)
Show SMILES OC(=O)COCCNc1c(F)cccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H22Cl2N6O4/c1-24(2)14-21-15(25(3)27-4)23-16(22-14)28-8-7-20-17(26)29-10-11-5-6-12(18)9-13(11)19/h5-6,9H,7-8,10H2,1-4H3,(H,20,26)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37970
PNG
(2-(2-((4-(((1,1,1,3,3,3-Hexafluoropropan-2- yl)oxy...)
Show SMILES OC(=O)COc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H24N6O2S2/c1-15-6-8-18(9-7-15)29-20(13-32-22-25-16(2)11-17(3)26-22)27-28-23(29)33-14-21(30)24-12-19-5-4-10-31-19/h4-11H,12-14H2,1-3H3,(H,24,30)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37954
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-((4- (tert-...)
Show SMILES CC(C)(C)OC(=O)CCCNc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H22N6O2S/c1-12(2)22-16(18-19-20-22)25-11-15(23)17-13-5-3-4-6-14(13)21-7-9-24-10-8-21/h3-6,12H,7-11H2,1-2H3,(H,17,23)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37963
PNG
(2-(2-((2-((4-(((1,1,1,3,3,3-Hexafluoropropan-2- yl...)
Show SMILES OC(=O)COCCNc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C14H13N5OS/c1-9(13(20)18-11-5-3-2-4-6-11)21-14-17-8-10(7-15)12(16)19-14/h2-6,8-9H,1H3,(H,18,20)(H2,16,17,19)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37995
PNG
(1-((2-cyano-6-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES OC(=O)C1(COc2c(CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)cccc2C#N)CC1
Show InChI InChI=1S/C21H22ClFN6O4/c1-13-4-7-18(33-13)21-25-27-29(26-21)12-20(31)28(14-5-6-17(23)16(22)9-14)11-19(30)24-10-15-3-2-8-32-15/h4-7,9,15H,2-3,8,10-12H2,1H3,(H,24,30)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37999
PNG
(1-((4-fluoro-2-((4-(((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES Cc1cc(F)cc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c1OCC1(CCCC1)C(O)=O
Show InChI InChI=1S/C11H13N5O2S/c1-7-4-13-8(5-12-7)10-14-15-11(19-10)16(2)9(17)6-18-3/h4-5H,6H2,1-3H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38001
PNG
(1-((2-fluoro-6-((4-(((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES OC(=O)C1(COc2c(F)cccc2CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)CCCC1
Show InChI InChI=1S/C11H12N4O2S/c1-2-17-9(16)7-18-11-13-10(14-15-11)8-4-3-5-12-6-8/h3-6H,2,7H2,1H3,(H,13,14,15)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38013
PNG
(1,1,1,3,3,3-hexafluoropropan-2-yl 4-(4-chloro- 2-(...)
Show SMILES CS(=O)(=O)NC(=O)COc1cc(Cl)ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H19FN2O4/c1-27-18-8-4-5-14-13-15(21(26)28-19(14)18)20(25)24-11-9-23(10-12-24)17-7-3-2-6-16(17)22/h2-8,13H,9-12H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38016
PNG
(1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-((1- ((meth...)
Show SMILES CS(=O)(=O)NC(=O)C1(COc2cc(ccc2CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F)CC1
Show InChI InChI=1S/C12H19NO5/c1-8(2)18-10(15)4-6-12(11(16)17)5-3-9(14)13-7-12/h8H,3-7H2,1-2H3,(H,13,14)(H,16,17)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37972
PNG
(5-(2-((4-(((1,1,1,3,3,3-Hexafluoropropan-2- yl)oxy...)
Show SMILES OC(=O)CCCCc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H23ClN2O6S/c1-29-18-11-14-10-15(21(26)23-17(14)12-19(18)30-2)13-24(8-5-9-25)31(27,28)20-7-4-3-6-16(20)22/h3-4,6-7,10-12,25H,5,8-9,13H2,1-2H3,(H,23,26)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37973
PNG
(1-(2-((4-(((1,1,1,3,3,3-Hexafluoropropan-2- yl)oxy...)
Show SMILES OC(=O)C1(CC1)Oc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H15N3O3S/c1-19-15(21)12-6-2-3-7-13(12)18-16(19)23-10-14(20)17-9-11-5-4-8-22-11/h2-8H,9-10H2,1H3,(H,17,20)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37955
PNG
(4-(2-((4-(((1,1,1,3,3,3-Hexafluoropropan-2- yl)oxy...)
Show SMILES OC(=O)CCCOc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H19N3O4S/c1-2-13-5-7-14(8-6-13)24-11-17-20-21-18(25-17)26-12-16(22)19-10-15-4-3-9-23-15/h3-9H,2,10-12H2,1H3,(H,19,22)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37956
PNG
(4-(5-Chloro-2-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES OC(=O)CCCOc1cc(Cl)ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H17N5O3S2/c1-2-23-12-5-3-10(4-6-12)18-15-19-11(8-25-15)7-14-20-21-16(24-14)26-9-13(17)22/h3-6,8H,2,7,9H2,1H3,(H2,17,22)(H,18,19)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37988
PNG
(1-((2-((4-(((1,1,1,3,3,3-hexafluoropropan-2- yl)ox...)
Show SMILES OC(=O)C1(COc2c(CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)cccc2C(F)(F)F)CC1
Show InChI InChI=1S/C13H23N3O2S/c1-5-16(6-2)7-8-19-13-14-11(17)10(9(3)4)12(18)15-13/h9H,5-8H2,1-4H3,(H2,14,15,17,18)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37990
PNG
(1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-fluoro- 4-m...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC2(CC2)C(=O)NS(C)(=O)=O)c1F
Show InChI InChI=1S/C16H12BrN3O3S/c1-9-13(15(22)19-11-6-4-10(17)5-7-11)24-16(18-9)20-14(21)12-3-2-8-23-12/h2-8H,1H3,(H,19,22)(H,18,20,21)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37991
PNG
(1-((2-fluoro-6-((4-(((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC2(CCCC2)C(O)=O)c1F
Show InChI InChI=1S/C21H21BrN2O4/c1-2-28-18-7-8-19-15(12-18)11-16(20(26)23-19)13-24(9-10-25)21(27)14-3-5-17(22)6-4-14/h3-8,11-12,25H,2,9-10,13H2,1H3,(H,23,26)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37993
PNG
(1-((4,5-difluoro-2-((4-(((1,1,1,3,3,3- hexafluorop...)
Show SMILES OC(=O)C1(COc2cc(F)c(F)cc2CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)CC1
Show InChI InChI=1S/C12H17N3O3S/c1-15(11(16)9-3-5-18-7-9)12-14-13-10(19-12)8-2-4-17-6-8/h8-9H,2-7H2,1H3
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37994
PNG
(1-((5-cyano-2-((4-(((1,1,1,3,3,3- hexafluoropropan...)
Show SMILES OC(=O)C1(COc2cc(ccc2CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C#N)CC1
Show InChI InChI=1S/C20H25N3O5S/c24-19(21-13-17-9-6-12-28-17)15-23(16-7-4-5-8-16)20(25)14-22-29(26,27)18-10-2-1-3-11-18/h1-3,6,9-12,16,22H,4-5,7-8,13-15H2,(H,21,24)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38002
PNG
(1-((5-fluoro-2-((4-(((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES OC(=O)C1(COc2cc(F)ccc2CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)CCCC1
Show InChI InChI=1S/C16H13N3O3/c20-15(13-6-3-9-22-13)18-19-14(10-7-8-10)17-12-5-2-1-4-11(12)16(19)21/h1-6,9-10H,7-8H2,(H,18,20)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37979
PNG
(1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(2- (cyclop...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC(=O)NS(=O)(=O)C2CC2)c1F
Show InChI InChI=1S/C19H27ClN6/c1-15-7-8-16(20)13-18(15)25-11-9-24(10-12-25)14-19-21-22-23-26(19)17-5-3-2-4-6-17/h7-8,13,17H,2-6,9-12,14H2,1H3
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37984
PNG
(1-((2-Cyano-4-fluoro-6-((4-(((1,1,1,3,3,3- hexaflu...)
Show SMILES OC(=O)C1(COc2c(CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)cc(F)cc2C#N)CC1
Show InChI InChI=1S/C15H21ClN2O2/c1-12(11-18-9-7-17(2)8-10-18)20-15(19)13-3-5-14(16)6-4-13/h3-6,12H,7-11H2,1-2H3
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37951
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-((4- ethoxy...)
Show SMILES CCOC(=O)CCCNc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H21N5O4/c1-3-11-29-17-9-7-14(8-10-17)19-22-24-25(23-19)13-18(26)21-16-6-4-5-15(12-16)20(27)28-2/h4-10,12H,3,11,13H2,1-2H3,(H,21,26)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37961
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-((4- oxo-4-...)
Show SMILES CC(C)(C)C(=O)OCOC(=O)CCCNc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H16N4O2/c20-14(12-6-1-3-8-16-12)18-10-5-11-19-15(21)13-7-2-4-9-17-13/h1-4,6-9H,5,10-11H2,(H,18,20)(H,19,21)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37964
PNG
(2-(2-((4-Chloro-2-((4-(((1,1,1,3,3,3- hexafluoropr...)
Show SMILES OC(=O)COCCNc1ccc(Cl)cc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H27N3O5/c1-16(2)22(25(31)26-15-19-7-6-14-33-19)28-24(30)20-8-4-5-9-21(20)27-23(29)17-10-12-18(32-3)13-11-17/h4-14,16,22H,15H2,1-3H3,(H,26,31)(H,27,29)(H,28,30)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37987
PNG
(1-((2-fluoro-6-((4-(((1,1,1,3,3,3- hexafluoropropa...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC2(CC2)C(O)=O)c1F
Show InChI InChI=1S/C13H17NO4S/c1-9(18-13(16)11-5-3-7-19-11)12(15)14-8-10-4-2-6-17-10/h3,5,7,9-10H,2,4,6,8H2,1H3,(H,14,15)
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n/an/a 5.50E+3n/an/an/an/an/a25



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38014
PNG
(1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-chloro- 4-m...)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(OCC2(CC2)C(=O)NS(C)(=O)=O)c1Cl
Show InChI InChI=1S/C13H17NO4/c15-12(14-10-5-2-1-3-6-10)9-18-13(16)11-7-4-8-17-11/h4,7-8,10H,1-3,5-6,9H2,(H,14,15)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37975
PNG
(4-(2-((4-(((1,1,1,3,3,3-hexafluoropropan-2- yl)oxy...)
Show SMILES CC(C)(OC=O)C#Cc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C13H12N2O4/c1-18-12(16)10-8-15(9-6-4-3-5-7-9)14-11(10)13(17)19-2/h3-8H,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM37962
PNG
(1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-((4-(1- (is...)
Show SMILES CC(C)C(=O)OC(C)OC(=O)CCCNc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H26FN5O/c1-15-14-19(23-8-3-9-26-10-12-28-13-11-26)27-21(24-15)20(16(2)25-27)17-4-6-18(22)7-5-17/h4-7,14,23H,3,8-13H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38005
PNG
((1S,3R)-3-(2-((4-(((1,1,1,3,3,3- hexafluoropropan-...)
Show SMILES OC(=O)[C@H]1CC[C@H](C1)Oc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H22N2O3S2/c1-4-19-18(21)13-20(15-7-5-14(2)6-8-15)25(22,23)17-11-9-16(24-3)10-12-17/h5-12H,4,13H2,1-3H3,(H,19,21)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (human))
BDBM38007
PNG
((1r,3r)-3-(2-((4-(((1,1,1,3,3,3- hexafluoropropan-...)
Show SMILES OC(=O)[C@H]1C[C@@H](C1)Oc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H17N5O2/c1-9-4-5-12-10(2)17-15(19-13(12)6-9)21-16-18-11(8-23-3)7-14(22)20-16/h4-7H,8H2,1-3H3,(H2,17,18,19,20,21,22)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with varying...


US Patent US10093635 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%