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Patent code US10093655

Compile Data Set for Download or QSAR
Found 81 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160878
PNG
(US10093655, Example 48 | US9107923, 48)
Show SMILES Cc1cc(Oc2ncccc2I)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C18H16IN3O2/c1-10-9-13(24-18-15(19)5-4-8-20-18)6-7-14(10)16-11(2)17(23)22-21-12(16)3/h4-9H,1-3H3,(H,22,23)
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US Patent
0.571n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160912
PNG
(US10093655, Example 2 | US9107923, 1 | US9107923, ...)
Show SMILES Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H21N3O3/c1-12-11-15(27-20-17(14-6-7-14)5-4-10-22-20)8-9-16(12)18-13(2)19(25)23-21(26)24(18)3/h4-5,8-11,14H,6-7H2,1-3H3,(H,23,25,26)
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US Patent
3.11n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160861
PNG
(US10093655, Example 31 | US9107923, 31)
Show SMILES Cc1ccnc(Oc2ccc(c(C)c2)-c2c(C)c(=O)[nH]c(=O)n2C)c1Cl
Show InChI InChI=1S/C19H18ClN3O3/c1-10-7-8-21-18(15(10)20)26-13-5-6-14(11(2)9-13)16-12(3)17(24)22-19(25)23(16)4/h5-9H,1-4H3,(H,22,24,25)
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US Patent
3.61n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160894
PNG
(US10093655, Example 64 | US9107923, 64)
Show SMILES COc1ccnc(Oc2ccc(c(C)c2)-c2c(C)n[nH]c(=O)c2C)c1C(F)(F)F
Show InChI InChI=1S/C20H18F3N3O3/c1-10-9-13(5-6-14(10)16-11(2)18(27)26-25-12(16)3)29-19-17(20(21,22)23)15(28-4)7-8-24-19/h5-9H,1-4H3,(H,26,27)
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US Patent
4.17n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160871
PNG
(US10093655, Example 41 | US9107923, 41)
Show SMILES Cc1ccnc(Oc2ccc(c(C)c2)-c2c(C)n[nH]c(=O)c2C)c1Cl
Show InChI InChI=1S/C19H18ClN3O2/c1-10-7-8-21-19(17(10)20)25-14-5-6-15(11(2)9-14)16-12(3)18(24)23-22-13(16)4/h5-9H,1-4H3,(H,23,24)
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5.41n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289103
PNG
((−)-6-(4-{[3-(Difluoromethoxy)pyridin-2-yl]o...)
Show SMILES Cc1c(-c2ccc(Oc3ncccc3OC(F)F)cc2)n(C)c(=O)nc1=O
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6.91n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160876
PNG
(US10093655, Example 46 | US9107923, 46)
Show SMILES Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C21H21N3O2/c1-12-11-16(26-21-18(15-6-7-15)5-4-10-22-21)8-9-17(12)19-13(2)20(25)24-23-14(19)3/h4-5,8-11,15H,6-7H2,1-3H3,(H,24,25)
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US Patent
7.66n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160867
PNG
(US10093655, Example 37 | US9107923, 37)
Show SMILES CC(=C)c1cccnc1Oc1ccc(c(C)c1)-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H21N3O3/c1-12(2)16-7-6-10-22-20(16)27-15-8-9-17(13(3)11-15)18-14(4)19(25)23-21(26)24(18)5/h6-11H,1H2,2-5H3,(H,23,25,26)
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US Patent
8.42n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289097
PNG
((−)-1,5-Dimethyl-6-(2-methyl-4-{[3-(trifluor...)
Show SMILES Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)nc(=O)n1C
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8.54n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160884
PNG
(US10093655, Example 55 | US9107923, 54 | US9107923...)
Show SMILES Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C18H16ClN3O3/c1-10-9-12(25-17-14(19)5-4-8-20-17)6-7-13(10)15-11(2)16(23)21-18(24)22(15)3/h4-9H,1-3H3,(H,21,23,24)
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9.33n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160873
PNG
(US10093655, Example 43 | US9107923, 43)
Show SMILES Cc1cc(Oc2ncccc2Br)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C18H16BrN3O2/c1-10-9-13(24-18-15(19)5-4-8-20-18)6-7-14(10)16-11(2)17(23)22-21-12(16)3/h4-9H,1-3H3,(H,22,23)
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9.65n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160880
PNG
(US10093655, Example 50 | US9107923, 50)
Show SMILES Cc1ccnc(Oc2ccc(c(C)c2)-c2c(C)c(=O)[nH]c(=O)n2C)c1OC(F)F
Show InChI InChI=1S/C20H19F2N3O4/c1-10-7-8-23-18(16(10)29-19(21)22)28-13-5-6-14(11(2)9-13)15-12(3)17(26)24-20(27)25(15)4/h5-9,19H,1-4H3,(H,24,26,27)
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US Patent
10.1n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289101
PNG
(6-{4-[(3-Chloro-4-methylpyridin-2-yl)oxy]phenyl}-1...)
Show SMILES Cc1ccnc(Oc2ccc(cc2)-c2c(C)c(=O)nc(=O)n2C)c1Cl
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10.9n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160892
PNG
(US10093655, Example 62 | US9107923, 62)
Show SMILES Cc1ccnc(Oc2ccc(c(C)c2)-c2c(C)n[nH]c(=O)c2C)c1C(F)(F)F
Show InChI InChI=1S/C20H18F3N3O2/c1-10-7-8-24-19(17(10)20(21,22)23)28-14-5-6-15(11(2)9-14)16-12(3)18(27)26-25-13(16)4/h5-9H,1-4H3,(H,26,27)
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US Patent
12.1n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289111
PNG
(1,5-Dimethyl-6-(7-{[3-(trifluoromethyl)pyridin-2-y...)
Show SMILES Cc1c(-c2ccc(Oc3ncccc3C(F)(F)F)c3[nH]ccc23)n(C)c(=O)nc1=O
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12.9n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160893
PNG
(US10093655, Example 63 | US9107923, 63)
Show SMILES COc1ccnc(Oc2ccc(c(C)c2)-c2c(C)n[nH]c(=O)c2C)c1C(F)F
Show InChI InChI=1S/C20H19F2N3O3/c1-10-9-13(28-20-17(18(21)22)15(27-4)7-8-23-20)5-6-14(10)16-11(2)19(26)25-24-12(16)3/h5-9,18H,1-4H3,(H,25,26)
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13.4n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160869
PNG
(US10093655, Example 39 | US9107923, 39)
Show SMILES Cc1cc(Oc2cc(ccn2)C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H21N3O3/c1-12-10-16(27-18-11-15(8-9-22-18)14-4-5-14)6-7-17(12)19-13(2)20(25)23-21(26)24(19)3/h6-11,14H,4-5H2,1-3H3,(H,23,25,26)
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US Patent
15n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160912
PNG
(US10093655, Example 2 | US9107923, 1 | US9107923, ...)
Show SMILES Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H21N3O3/c1-12-11-15(27-20-17(14-6-7-14)5-4-10-22-20)8-9-16(12)18-13(2)19(25)23-21(26)24(18)3/h4-5,8-11,14H,6-7H2,1-3H3,(H,23,25,26)
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US Patent
15.3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160898
PNG
(US10093655, Example 68 | US9107923, 68)
Show SMILES Cc1cc(Sc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C19H16F3N3O2S/c1-10-9-12(28-17-14(19(20,21)22)5-4-8-23-17)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27)
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16.9n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289104
PNG
((−)-6-(4-{[3-(Difluoromethyl)pyridin-2-yl]ox...)
Show SMILES Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2)n(C)c(=O)nc1=O
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17.5n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160875
PNG
(US10093655, Example 45 | US9107923, 45)
Show SMILES Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C19H17F2N3O4/c1-10-9-12(27-17-14(28-18(20)21)5-4-8-22-17)6-7-13(10)15-11(2)16(25)23-19(26)24(15)3/h4-9,18H,1-3H3,(H,23,25,26)
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18.6n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289098
PNG
((+)-1,5-Dimethyl-6-(2-methyl-4-{[3-(trifluoromethy...)
Show SMILES Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)nc(=O)n1C
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21n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160891
PNG
(US10093655, Example 61 | US9107923, 61)
Show SMILES COc1ccnc(Oc2ccc(c(C)c2)-c2c(C)n[nH]c(=O)c2C)c1C
Show InChI InChI=1S/C20H21N3O3/c1-11-10-15(26-20-12(2)17(25-5)8-9-21-20)6-7-16(11)18-13(3)19(24)23-22-14(18)4/h6-10H,1-5H3,(H,23,24)
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US Patent
23.8n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160884
PNG
(US10093655, Example 55 | US9107923, 54 | US9107923...)
Show SMILES Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C18H16ClN3O3/c1-10-9-12(25-17-14(19)5-4-8-20-17)6-7-13(10)15-11(2)16(23)21-18(24)22(15)3/h4-9H,1-3H3,(H,21,23,24)
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US Patent
24.2n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160895
PNG
(US10093655, Example 66 | US9107923, 65)
Show SMILES Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H16F3N3O2/c1-10-9-13(27-18-15(19(20,21)22)5-4-8-23-18)6-7-14(10)16-11(2)17(26)25-24-12(16)3/h4-9H,1-3H3,(H,25,26)
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26.9n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160887
PNG
(US10093655, Example 57 | US9107923, 57)
Show SMILES Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C18H16ClN3O2/c1-10-9-13(24-18-15(19)5-4-8-20-18)6-7-14(10)16-11(2)17(23)22-21-12(16)3/h4-9H,1-3H3,(H,22,23)
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30.5n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160868
PNG
(US10093655, Example 38 | US9107923, 38)
Show SMILES CC(C)c1cccnc1Oc1ccc(c(C)c1)-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H23N3O3/c1-12(2)16-7-6-10-22-20(16)27-15-8-9-17(13(3)11-15)18-14(4)19(25)23-21(26)24(18)5/h6-12H,1-5H3,(H,23,25,26)
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31.1n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160908
PNG
(US10093655, Example 78 | US9107923, 78)
Show SMILES Cc1ccnc(Oc2ccc(c(C)c2)-c2c(C)cnc(=O)n2C)c1Cl
Show InChI InChI=1S/C19H18ClN3O2/c1-11-7-8-21-18(16(11)20)25-14-5-6-15(12(2)9-14)17-13(3)10-22-19(24)23(17)4/h5-10H,1-4H3
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32.3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289096
PNG
(6-{4-[(3-Chloropyridin-2-yl)oxy]-2-methylphenyl}-5...)
Show SMILES CCc1c(-c2ccc(Oc3ncccc3Cl)cc2C)n(C)c(=O)nc1=O
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33.1n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160895
PNG
(US10093655, Example 66 | US9107923, 65)
Show SMILES Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H16F3N3O2/c1-10-9-13(27-18-15(19(20,21)22)5-4-8-23-18)6-7-14(10)16-11(2)17(26)25-24-12(16)3/h4-9H,1-3H3,(H,25,26)
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34.4n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289109
PNG
(6-{4-[(3-Chloropyridin-2-yl)sulfanyl]-2-methylphen...)
Show SMILES Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)nc(=O)n1C
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35.7n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160857
PNG
(US10093655, Example 27 | US9107923, 27)
Show SMILES Cc1ccnc(Oc2ccc(c(C)c2)-c2c(C)c(=O)[nH]c(=O)n2C)c1F
Show InChI InChI=1S/C19H18FN3O3/c1-10-7-8-21-18(15(10)20)26-13-5-6-14(11(2)9-13)16-12(3)17(24)22-19(25)23(16)4/h5-9H,1-4H3,(H,22,24,25)
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36.2n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160899
PNG
(US10093655, Example 69 | US9107923, 69)
Show SMILES Cc1c(-c2ccc(Oc3ncccc3C3CC3)cc2)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C20H19N3O3/c1-12-17(23(2)20(25)22-18(12)24)14-7-9-15(10-8-14)26-19-16(13-5-6-13)4-3-11-21-19/h3-4,7-11,13H,5-6H2,1-2H3,(H,22,24,25)
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38.3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160855
PNG
(US10093655, Example 25 | US9107923, 25)
Show SMILES Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C19H17Cl2N3O3/c1-9-7-12(27-18-15(21)10(2)14(20)8-22-18)5-6-13(9)16-11(3)17(25)23-19(26)24(16)4/h5-8H,1-4H3,(H,23,25,26)
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38.5n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160914
PNG
(US10093655, Example 4 | US9107923, 3 | US9107923, ...)
Show SMILES Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C18H15ClFN3O3/c1-9-6-12(26-17-14(19)7-11(20)8-21-17)4-5-13(9)15-10(2)16(24)22-18(25)23(15)3/h4-8H,1-3H3,(H,22,24,25)
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40.6n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160903
PNG
(US10093655, Example 73 | US9107923, 73)
Show SMILES Cc1ccnc(Oc2ccc(c(C)c2)-c2c(C)ncc(=O)n2C)c1Cl
Show InChI InChI=1S/C19H18ClN3O2/c1-11-7-8-21-19(17(11)20)25-14-5-6-15(12(2)9-14)18-13(3)22-10-16(24)23(18)4/h5-10H,1-4H3
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43.4n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289106
PNG
((+)-5-(4-{[3-(Difluoromethyl)pyridin-2-yl]oxy}-2-m...)
Show SMILES Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)nc(=O)n1C
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44.3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160853
PNG
(US10093655, Example 23 | US9107923, 23)
Show SMILES Cc1ccnc(Oc2ccc(c(C)c2)-c2c(C)c(=O)[nH]c(=O)n2C)c1[N+]#[C-]
Show InChI InChI=1S/C20H18N4O3/c1-11-8-9-22-19(16(11)21-4)27-14-6-7-15(12(2)10-14)17-13(3)18(25)23-20(26)24(17)5/h6-10H,1-3,5H3,(H,23,25,26)
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45.9n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160850
PNG
(US10093655, Example 20 | US9107923, 20)
Show SMILES CCc1cccnc1Oc1ccc(c(C)c1)-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C20H21N3O3/c1-5-14-7-6-10-21-19(14)26-15-8-9-16(12(2)11-15)17-13(3)18(24)22-20(25)23(17)4/h6-11H,5H2,1-4H3,(H,22,24,25)
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52.7n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289105
PNG
((+)-6-(4-{[3-(Difluoromethyl)pyridin-2-yl]oxy}-2-m...)
Show SMILES Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2)n(C)c(=O)nc1=O
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54.7n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289102
PNG
(6-(4-{[3-(Difluoromethyl)pyridin-2-yl]oxy}-2-methy...)
Show SMILES CCn1c(-c2ccc(Oc3ncccc3C(F)F)cc2)c(C)c(=O)nc1=O
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55.1n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160911
PNG
(US10093655, Example 81 | US9107923, 81)
Show SMILES Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C1CC1
Show InChI InChI=1S/C21H19F2N3O3/c1-11-10-14(29-20-16(18(22)23)4-3-9-24-20)7-8-15(11)17-12(2)19(27)25-21(28)26(17)13-5-6-13/h3-4,7-10,13,18H,5-6H2,1-2H3,(H,25,27,28)
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58n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289095
PNG
(6-{4-[(3-Chloropyridin-2-yl)oxy]-2-methylphenyl}-1...)
Show SMILES CCn1c(c(C)c(=O)nc1=O)-c1ccc(Oc2ncccc2Cl)cc1C
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58n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289107
PNG
((−)-5-(4-{[3-(Difluoromethyl)pyridin-2-yl]ox...)
Show SMILES Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)nc(=O)n1C
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59.1n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160882
PNG
(US10093655, Example 52 | US9107923, 52)
Show SMILES Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C19H16F3N3O4/c1-10-9-12(28-17-14(5-4-8-23-17)29-19(20,21)22)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27)
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63.1n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289100
PNG
((−)-6-{4-[(3-Chloro-5-methylpyridin-2-yl)oxy...)
Show SMILES Cc1cnc(Oc2ccc(c(C)c2)-c2c(C)c(=O)nc(=O)n2C)c(Cl)c1
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82.3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160877
PNG
(US10093655, Example 47 | US9107923, 47)
Show SMILES CCc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C20H19F2N3O3/c1-4-13-16(25(3)20(27)24-18(13)26)14-8-7-12(10-11(14)2)28-19-15(17(21)22)6-5-9-23-19/h5-10,17H,4H2,1-3H3,(H,24,26,27)
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82.3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160870
PNG
(US10093655, Example 40 | US9107923, 40)
Show SMILES Cc1cc(Oc2ncccc2O)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C18H17N3O4/c1-10-9-12(25-17-14(22)5-4-8-19-17)6-7-13(10)15-11(2)16(23)20-18(24)21(15)3/h4-9,22H,1-3H3,(H,20,23,24)
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82.7n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160852
PNG
(US10093655, Example 22 | US9107923, 22)
Show SMILES CCc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C18H16ClN3O3/c1-3-13-15(22(2)18(24)21-16(13)23)11-6-8-12(9-7-11)25-17-14(19)5-4-10-20-17/h4-10H,3H2,1-2H3,(H,21,23,24)
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82.7n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160888
PNG
(US10093655, Example 58 | US9107923, 58)
Show SMILES Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H17F2N3O3/c1-10-9-13(26-18-15(27-19(20)21)5-4-8-22-18)6-7-14(10)16-11(2)17(25)24-23-12(16)3/h4-9,19H,1-3H3,(H,24,25)
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US Patent
86.2n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160905
PNG
(US10093655, Example 75 | US9107923, 75)
Show SMILES Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C19H17F2N3O3/c1-11-9-13(26-18-15(27-19(20)21)5-4-8-22-18)6-7-14(11)17-12(2)23-10-16(25)24(17)3/h4-10,19H,1-3H3
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87n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160874
PNG
(US10093655, Example 44 | US9107923, 44)
Show SMILES Cc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C17H14ClN3O3/c1-10-14(21(2)17(23)20-15(10)22)11-5-7-12(8-6-11)24-16-13(18)4-3-9-19-16/h3-9H,1-2H3,(H,20,22,23)
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87.3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160858
PNG
(US10093655, Example 28 | US9107923, 28)
Show SMILES Cc1cc(Oc2ncc(Cl)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C18H15Cl2N3O3/c1-9-6-12(26-17-14(20)7-11(19)8-21-17)4-5-13(9)15-10(2)16(24)22-18(25)23(15)3/h4-8H,1-3H3,(H,22,24,25)
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88.9n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160854
PNG
(US10093655, Example 24 | US9107923, 24)
Show SMILES Cc1cc(Cl)cnc1Oc1ccc(c(C)c1)-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C19H18ClN3O3/c1-10-8-14(26-18-11(2)7-13(20)9-21-18)5-6-15(10)16-12(3)17(24)22-19(25)23(16)4/h5-9H,1-4H3,(H,22,24,25)
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US Patent
92.1n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160881
PNG
(US10093655, Example 51 | US9107923, 51)
Show SMILES Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H16F3N3O3/c1-10-9-13(27-18-15(5-4-8-23-18)28-19(20,21)22)6-7-14(10)16-11(2)17(26)25-24-12(16)3/h4-9H,1-3H3,(H,25,26)
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94.9n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160883
PNG
(US10093655, Example 53 | US9107923, 53)
Show SMILES Cc1c(-c2ccc(Oc3ncccc3OC(F)F)cc2)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C18H15F2N3O4/c1-10-14(23(2)18(25)22-15(10)24)11-5-7-12(8-6-11)26-16-13(27-17(19)20)4-3-9-21-16/h3-9,17H,1-2H3,(H,22,24,25)
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US Patent
109n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160909
PNG
(US10093655, Example 79 | US9107923, 79)
Show SMILES Cc1cnc(=O)n(C)c1-c1ccc(Oc2ncccc2C2CC2)cc1C
Show InChI InChI=1S/C21H21N3O2/c1-13-11-16(26-20-18(15-6-7-15)5-4-10-22-20)8-9-17(13)19-14(2)12-23-21(25)24(19)3/h4-5,8-12,15H,6-7H2,1-3H3
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109n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160856
PNG
(US10093655, Example 26 | US9107923, 26)
Show SMILES Cc1cc(Oc2ncc(Cl)cc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C19H16ClF2N3O3/c1-9-6-12(28-18-14(16(21)22)7-11(20)8-23-18)4-5-13(9)15-10(2)17(26)24-19(27)25(15)3/h4-8,16H,1-3H3,(H,24,26,27)
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117n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160914
PNG
(US10093655, Example 4 | US9107923, 3 | US9107923, ...)
Show SMILES Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C18H15ClFN3O3/c1-9-6-12(26-17-14(19)7-11(20)8-21-17)4-5-13(9)15-10(2)16(24)22-18(25)23(15)3/h4-8H,1-3H3,(H,22,24,25)
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118n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160864
PNG
(US10093655, Example 34 | US9107923, 34)
Show SMILES COc1cc(Oc2ccc(c(C)c2)-c2c(C)c(=O)[nH]c(=O)n2C)ncc1F
Show InChI InChI=1S/C19H18FN3O4/c1-10-7-12(27-16-8-15(26-4)14(20)9-21-16)5-6-13(10)17-11(2)18(24)22-19(25)23(17)3/h5-9H,1-4H3,(H,22,24,25)
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120n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM289099
PNG
((+)-6-{4-[(3-Chloro-5-methylpyridin-2-yl)oxy]-2-me...)
Show SMILES Cc1cnc(Oc2ccc(c(C)c2)-c2c(C)c(=O)nc(=O)n2C)c(Cl)c1
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120n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160900
PNG
(US10093655, Example 70 | US9107923, 70)
Show SMILES Cc1cc(F)cnc1Oc1ccc(c(C)c1)-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H18FN3O2/c1-10-8-15(25-19-11(2)7-14(20)9-21-19)5-6-16(10)17-12(3)18(24)23-22-13(17)4/h5-9H,1-4H3,(H,23,24)
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138n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160860
PNG
(US10093655, Example 30 | US9107923, 30)
Show SMILES Cc1cc(Oc2ccccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C18H17N3O3/c1-11-10-13(24-15-6-4-5-9-19-15)7-8-14(11)16-12(2)17(22)20-18(23)21(16)3/h4-10H,1-3H3,(H,20,22,23)
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156n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160872
PNG
(US10093655, Example 42 | US9107923, 42)
Show SMILES COc1cc(Oc2ccc(c(C)c2)-c2c(C)c(=O)[nH]c(=O)n2C)ncc1C
Show InChI InChI=1S/C20H21N3O4/c1-11-8-14(27-17-9-16(26-5)12(2)10-21-17)6-7-15(11)18-13(3)19(24)22-20(25)23(18)4/h6-10H,1-5H3,(H,22,24,25)
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187n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160901
PNG
(US10093655, Example 71 | US9107923, 71)
Show SMILES Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C21H21N3O2/c1-13-11-16(26-21-18(15-6-7-15)5-4-10-22-21)8-9-17(13)20-14(2)23-12-19(25)24(20)3/h4-5,8-12,15H,6-7H2,1-3H3
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216n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160863
PNG
(US10093655, Example 33 | US9107923, 33)
Show SMILES Cc1cc(Oc2ncccc2OC2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H21N3O4/c1-12-11-15(28-20-17(5-4-10-22-20)27-14-6-7-14)8-9-16(12)18-13(2)19(25)23-21(26)24(18)3/h4-5,8-11,14H,6-7H2,1-3H3,(H,23,25,26)
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224n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160902
PNG
(US10093655, Example 72 | US9107923, 72)
Show SMILES Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C19H17Cl2N3O2/c1-10-7-13(26-19-17(21)11(2)15(20)8-23-19)5-6-14(10)18-12(3)22-9-16(25)24(18)4/h5-9H,1-4H3
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227n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160865
PNG
(US10093655, Example 35 | US9107923, 35)
Show SMILES Cc1cc(Oc2ncccc2N2CCC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H22N4O3/c1-13-12-15(28-20-17(6-4-9-22-20)25-10-5-11-25)7-8-16(13)18-14(2)19(26)23-21(27)24(18)3/h4,6-9,12H,5,10-11H2,1-3H3,(H,23,26,27)
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246n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160879
PNG
(US10093655, Example 49 | US9107923, 49)
Show SMILES Cc1cc(Oc2ncccc2C2COC2)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C21H21N3O3/c1-12-9-16(27-21-18(5-4-8-22-21)15-10-26-11-15)6-7-17(12)19-13(2)20(25)24-23-14(19)3/h4-9,15H,10-11H2,1-3H3,(H,24,25)
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288n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160851
PNG
(US10093655, Example 21 | US9107923, 21)
Show SMILES CCn1c(-c2ccc(Oc3ncccc3Cl)cc2)c(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C18H16ClN3O3/c1-3-22-15(11(2)16(23)21-18(22)24)12-6-8-13(9-7-12)25-17-14(19)5-4-10-20-17/h4-10H,3H2,1-2H3,(H,21,23,24)
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314n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160907
PNG
(US10093655, Example 77 | US9107923, 77)
Show SMILES Cc1cnc(=O)n(C)c1-c1ccc(Oc2ncccc2C(F)(F)F)cc1C
Show InChI InChI=1S/C19H16F3N3O2/c1-11-9-13(27-17-15(19(20,21)22)5-4-8-23-17)6-7-14(11)16-12(2)10-24-18(26)25(16)3/h4-10H,1-3H3
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337n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160897
PNG
(US10093655, Example 67 | US9107923, 67)
Show SMILES Cc1ccnc(Oc2ccc(cc2)-c2c(C)n[nH]c(=O)c2C)c1
Show InChI InChI=1S/C18H17N3O2/c1-11-8-9-19-16(10-11)23-15-6-4-14(5-7-15)17-12(2)18(22)21-20-13(17)3/h4-10H,1-3H3,(H,21,22)
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345n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160910
PNG
(US10093655, Example 80 | US9107923, 80)
Show SMILES Cc1cnc(=O)n(C)c1-c1ccc(Oc2ncccc2Cl)cc1C
Show InChI InChI=1S/C18H16ClN3O2/c1-11-9-13(24-17-15(19)5-4-8-20-17)6-7-14(11)16-12(2)10-21-18(23)22(16)3/h4-10H,1-3H3
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349n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160906
PNG
(US10093655, Example 76 | US9107923, 76)
Show SMILES Cc1cnc(=O)n(C)c1-c1ccc(Oc2ncc(Cl)c(C)c2Cl)cc1C
Show InChI InChI=1S/C19H17Cl2N3O2/c1-10-7-13(26-18-16(21)12(3)15(20)9-22-18)5-6-14(10)17-11(2)8-23-19(25)24(17)4/h5-9H,1-4H3
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354n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160904
PNG
(US10093655, Example 74 | US9107923, 74)
Show SMILES Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C18H16ClN3O2/c1-11-9-13(24-18-15(19)5-4-8-20-18)6-7-14(11)17-12(2)21-10-16(23)22(17)3/h4-10H,1-3H3
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381n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160886
PNG
(US10093655, Example 56 | US9107923, 56)
Show SMILES Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C#N)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C19H14F2N4O3/c1-10-15(25(2)19(27)24-17(10)26)13-6-5-12(8-11(13)9-22)28-18-14(16(20)21)4-3-7-23-18/h3-8,16H,1-2H3,(H,24,26,27)
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428n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160859
PNG
(US10093655, Example 29 | US9107923, 29)
Show SMILES Cc1cc(Oc2ncccc2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C18H16FN3O3/c1-10-9-12(25-17-14(19)5-4-8-20-17)6-7-13(10)15-11(2)16(23)21-18(24)22(15)3/h4-9H,1-3H3,(H,21,23,24)
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489n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160862
PNG
(US10093655, Example 32 | US9107923, 32)
Show SMILES Cc1cc(Oc2ncccc2N2CC(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H21FN4O3/c1-12-9-15(29-20-17(5-4-8-23-20)26-10-14(22)11-26)6-7-16(12)18-13(2)19(27)24-21(28)25(18)3/h4-9,14H,10-11H2,1-3H3,(H,24,27,28)
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650n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160890
PNG
(US10093655, Example 60 | US9107923, 60)
Show SMILES COC(=O)c1cccnc1Oc1ccc(c(C)c1)-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C20H19N3O4/c1-11-10-14(27-19-16(20(25)26-4)6-5-9-21-19)7-8-15(11)17-12(2)18(24)23-22-13(17)3/h5-10H,1-4H3,(H,23,24)
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767n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160866
PNG
(US10093655, Example 36 | US9107923, 36)
Show SMILES Cc1cc(Oc2ncccc2N2CC(F)(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
Show InChI InChI=1S/C21H20F2N4O3/c1-12-9-14(6-7-15(12)17-13(2)18(28)25-20(29)26(17)3)30-19-16(5-4-8-24-19)27-10-21(22,23)11-27/h4-9H,10-11H2,1-3H3,(H,25,28,29)
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826n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM160889
PNG
(US10093655, Example 59 | US9107923, 59)
Show SMILES Cc1cc(Oc2ncccc2C(N)=O)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H18N4O3/c1-10-9-13(26-19-15(17(20)24)5-4-8-21-19)6-7-14(10)16-11(2)18(25)23-22-12(16)3/h4-9H,1-3H3,(H2,20,24)(H,23,25)
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1.22E+3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...


US Patent US10093655 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%