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Patent code US10093660

Compile Data Set for Download or QSAR

Found 261 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289164
PNG
(US10093660, Example 1.35)
Show SMILES O[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C21H20ClFN4O4S/c22-14-7-13(27-32(29)4-1-5-32)8-16-20(14)21(25-11-24-16)26-15-3-2-12(23)6-18(15)31-19-10-30-9-17(19)28/h2-3,6-8,11,17,19,28H,1,4-5,9-10H2,(H,24,25,26)/t17-,19+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289125
PNG
(US10093660, Example 1.6)
Show SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C23H24ClFN4O4S/c1-31-20-11-32-12-21(20)33-19-8-14(25)4-5-17(19)28-23-22-16(24)9-15(10-18(22)26-13-27-23)29-34(30)6-2-3-7-34/h4-5,8-10,13,20-21H,2-3,6-7,11-12H2,1H3,(H,26,27,28)/t20-,21+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289370
PNG
(US10093660, Example 9.5)
Show SMILES COc1cc(cc2ncnc(Nc3ccc(Cl)nc3O[C@H]3COC[C@@H]3O)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C21H22ClN5O5S/c1-30-16-8-12(27-33(29)5-2-6-33)7-14-19(16)20(24-11-23-14)25-13-3-4-18(22)26-21(13)32-17-10-31-9-15(17)28/h3-4,7-8,11,15,17,28H,2,5-6,9-10H2,1H3,(H,23,24,25)/t15-,17-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289396
PNG
(US10093660, Example 10.1)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@H]3OCCF)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C25H28F2N4O4S/c1-16-10-18(31-36(32)8-2-3-9-36)12-20-24(16)25(29-15-28-20)30-19-5-4-17(27)11-21(19)35-23-14-33-13-22(23)34-7-6-26/h4-5,10-12,15,22-23H,2-3,6-9,13-14H2,1H3,(H,28,29,30)/t22-,23+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289169
PNG
(US10093660, Example 14.1 | US10093660, Example 2.2)
Show SMILES CO[C@H]1COC[C@H]1Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C23H27N5O4S/c1-15-10-16(28-33(29)8-3-4-9-33)11-18-21(15)22(26-14-25-18)27-17-6-5-7-24-23(17)32-20-13-31-12-19(20)30-2/h5-7,10-11,14,19-20H,3-4,8-9,12-13H2,1-2H3,(H,25,26,27)/t19-,20+/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289150
PNG
(US10093660, Example 1.22)
Show SMILES O[C@@H]1COC[C@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C21H20ClFN4O4S/c22-14-7-13(27-32(29)4-1-5-32)8-16-20(14)21(25-11-24-16)26-15-3-2-12(23)6-18(15)31-19-10-30-9-17(19)28/h2-3,6-8,11,17,19,28H,1,4-5,9-10H2,(H,24,25,26)/t17-,19-/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289177
PNG
(US10093660, Example 14.8 | US10093660, Example 2.9)
Show SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O
Show InChI InChI=1S/C22H25FN4O4S/c1-13-7-15(27-32(3,4)28)9-17-21(13)22(25-12-24-17)26-16-6-5-14(23)8-18(16)31-20-11-30-10-19(20)29-2/h5-9,12,19-20H,10-11H2,1-4H3,(H,24,25,26)/t19-,20+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289250
PNG
(US10093660, Example 2.56)
Show SMILES CO[C@@H]1CCC(CO1)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C24H27FN4O4S/c1-15-10-17(29-34(30)8-3-9-34)12-20-23(15)24(27-14-26-20)28-19-6-4-16(25)11-21(19)33-18-5-7-22(31-2)32-13-18/h4,6,10-12,14,18,22H,3,5,7-9,13H2,1-2H3,(H,26,27,28)/t18?,22-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289176
PNG
(US10093660, Example 14.6 | US10093660, Example 2.8)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@H]3O)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C23H25FN4O4S/c1-14-8-16(28-33(30)6-2-3-7-33)10-18-22(14)23(26-13-25-18)27-17-5-4-15(24)9-20(17)32-21-12-31-11-19(21)29/h4-5,8-10,13,19,21,29H,2-3,6-7,11-12H2,1H3,(H,25,26,27)/t19-,21+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289124
PNG
(US10093660, Example 1.5 | US10093660, Example 14.1...)
Show SMILES O[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H22ClFN4O4S/c23-15-8-14(28-33(30)5-1-2-6-33)9-17-21(15)22(26-12-25-17)27-16-4-3-13(24)7-19(16)32-20-11-31-10-18(20)29/h3-4,7-9,12,18,20,29H,1-2,5-6,10-11H2,(H,25,26,27)/t18-,20+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289145
PNG
(US10093660, Example 1.17)
Show SMILES O[C@H]1COC[C@@H]1Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C21H21Cl2N5O4S/c22-13-7-12(28-33(30)5-1-2-6-33)8-15-19(13)20(25-11-24-15)26-14-3-4-18(23)27-21(14)32-17-10-31-9-16(17)29/h3-4,7-8,11,16-17,29H,1-2,5-6,9-10H2,(H,24,25,26)/t16-,17-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289148
PNG
(US10093660, Example 1.20)
Show SMILES O[C@H]1COC[C@@H]1Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C21H21ClFN5O4S/c22-18-4-3-14(21(27-18)32-17-10-31-9-16(17)29)26-20-19-13(23)7-12(8-15(19)24-11-25-20)28-33(30)5-1-2-6-33/h3-4,7-8,11,16-17,29H,1-2,5-6,9-10H2,(H,24,25,26)/t16-,17-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289153
PNG
(US10093660, Example 1.25)
Show SMILES O[C@@H]1COC[C@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H22ClFN4O4S/c23-15-8-14(28-33(30)5-1-2-6-33)9-17-21(15)22(26-12-25-17)27-16-4-3-13(24)7-19(16)32-20-11-31-10-18(20)29/h3-4,7-9,12,18,20,29H,1-2,5-6,10-11H2,(H,25,26,27)/t18-,20-/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289157
PNG
(US10093660, Example 1.29)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(Cl)cc3O[C@H]3COC[C@@H]3O)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C22H23ClN4O4S/c1-13-7-15(27-32(29)5-2-6-32)9-17-21(13)22(25-12-24-17)26-16-4-3-14(23)8-19(16)31-20-11-30-10-18(20)28/h3-4,7-9,12,18,20,28H,2,5-6,10-11H2,1H3,(H,24,25,26)/t18-,20-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289126
PNG
(US10093660, Example 1.7)
Show SMILES O[C@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C21H20ClFN4O4S/c22-14-7-13(27-32(29)4-1-5-32)8-16-20(14)21(25-11-24-16)26-15-3-2-12(23)6-18(15)31-19-10-30-9-17(19)28/h2-3,6-8,11,17,19,28H,1,4-5,9-10H2,(H,24,25,26)/t17-,19-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289131
PNG
(US10093660, Example 1.9)
Show SMILES O[C@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H22ClFN4O4S/c23-15-8-14(28-33(30)5-1-2-6-33)9-17-21(15)22(26-12-25-17)27-16-4-3-13(24)7-19(16)32-20-11-31-10-18(20)29/h3-4,7-9,12,18,20,29H,1-2,5-6,10-11H2,(H,25,26,27)/t18-,20-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289200
PNG
(US10093660, Example 2.29)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C23H25FN4O4S/c1-14-8-16(28-33(30)6-2-3-7-33)10-18-22(14)23(26-13-25-18)27-17-5-4-15(24)9-20(17)32-21-12-31-11-19(21)29/h4-5,8-10,13,19,21,29H,2-3,6-7,11-12H2,1H3,(H,25,26,27)/t19-,21-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289124
PNG
(US10093660, Example 1.5 | US10093660, Example 14.1...)
Show SMILES O[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H22ClFN4O4S/c23-15-8-14(28-33(30)5-1-2-6-33)9-17-21(15)22(26-12-25-17)27-16-4-3-13(24)7-19(16)32-20-11-31-10-18(20)29/h3-4,7-9,12,18,20,29H,1-2,5-6,10-11H2,(H,25,26,27)/t18-,20+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289196
PNG
(US10093660, Example 2.25)
Show SMILES Cc1cc(cc2ncnc(Nc3cccnc3O[C@H]3COC[C@H]3OCCF)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C24H28FN5O4S/c1-16-11-17(30-35(31)9-2-3-10-35)12-19-22(16)23(28-15-27-19)29-18-5-4-7-26-24(18)34-21-14-32-13-20(21)33-8-6-25/h4-5,7,11-12,15,20-21H,2-3,6,8-10,13-14H2,1H3,(H,27,28,29)/t20-,21+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289366
PNG
(US10093660, Example 9.1)
Show SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(OC)c12)N=S(C)(C)=O
Show InChI InChI=1S/C22H25FN4O5S/c1-29-18-9-14(27-33(3,4)28)8-16-21(18)22(25-12-24-16)26-15-6-5-13(23)7-17(15)32-20-11-31-10-19(20)30-2/h5-9,12,19-20H,10-11H2,1-4H3,(H,24,25,26)/t19-,20+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289144
PNG
(US10093660, Example 1.16)
Show SMILES O[C@H]1COC[C@@H]1Oc1nc(Cl)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C20H19Cl2N5O4S/c21-12-6-11(27-32(29)4-1-5-32)7-14-18(12)19(24-10-23-14)25-13-2-3-17(22)26-20(13)31-16-9-30-8-15(16)28/h2-3,6-7,10,15-16,28H,1,4-5,8-9H2,(H,23,24,25)/t15-,16-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289176
PNG
(US10093660, Example 14.6 | US10093660, Example 2.8)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@H]3O)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C23H25FN4O4S/c1-14-8-16(28-33(30)6-2-3-7-33)10-18-22(14)23(26-13-25-18)27-17-5-4-15(24)9-20(17)32-21-12-31-11-19(21)29/h4-5,8-10,13,19,21,29H,2-3,6-7,11-12H2,1H3,(H,25,26,27)/t19-,21+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289252
PNG
(US10093660, Example 2.58)
Show SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C23H24F2N4O4S/c1-31-20-11-32-12-21(20)33-19-8-14(24)4-5-17(19)28-23-22-16(25)9-15(10-18(22)26-13-27-23)29-34(30)6-2-3-7-34/h4-5,8-10,13,20-21H,2-3,6-7,11-12H2,1H3,(H,26,27,28)/t20-,21+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289257
PNG
(US10093660, Example 2.63)
Show SMILES CO[C@@H]1CC[C@H](CO1)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O
Show InChI InChI=1S/C23H27FN4O4S/c1-14-9-16(28-33(3,4)29)11-19-22(14)23(26-13-25-19)27-18-7-5-15(24)10-20(18)32-17-6-8-21(30-2)31-12-17/h5,7,9-11,13,17,21H,6,8,12H2,1-4H3,(H,25,26,27)/t17-,21+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289123
PNG
(US10093660, Example 1.4)
Show SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O
Show InChI InChI=1S/C21H22ClFN4O4S/c1-29-18-9-30-10-19(18)31-17-6-12(23)4-5-15(17)26-21-20-14(22)7-13(27-32(2,3)28)8-16(20)24-11-25-21/h4-8,11,18-19H,9-10H2,1-3H3,(H,24,25,26)/t18-,19+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289299
PNG
(US10093660, Example 2.92)
Show SMILES O[C@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C21H20F2N4O4S/c22-12-2-3-15(18(6-12)31-19-10-30-9-17(19)28)26-21-20-14(23)7-13(8-16(20)24-11-25-21)27-32(29)4-1-5-32/h2-3,6-8,11,17,19,28H,1,4-5,9-10H2,(H,24,25,26)/t17-,19-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289127
PNG
(US10093660, Example 1.8)
Show SMILES CS(C)(=O)=Nc1cc(Cl)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)ncnc2c1
Show InChI InChI=1S/C20H20ClFN4O4S/c1-31(2,28)26-12-6-13(21)19-15(7-12)23-10-24-20(19)25-14-4-3-11(22)5-17(14)30-18-9-29-8-16(18)27/h3-7,10,16,18,27H,8-9H2,1-2H3,(H,23,24,25)/t16-,18-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289367
PNG
(US10093660, Example 9.2)
Show SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(OC)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C24H27FN4O5S/c1-31-20-11-16(29-35(30)7-3-4-8-35)10-18-23(20)24(27-14-26-18)28-17-6-5-15(25)9-19(17)34-22-13-33-12-21(22)32-2/h5-6,9-11,14,21-22H,3-4,7-8,12-13H2,1-2H3,(H,26,27,28)/t21-,22+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289397
PNG
(US10093660, Example 10.2)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@H]3OCCF)c12)N=S(C)(C)=O
Show InChI InChI=1S/C23H26F2N4O4S/c1-14-8-16(29-34(2,3)30)10-18-22(14)23(27-13-26-18)28-17-5-4-15(25)9-19(17)33-21-12-31-11-20(21)32-7-6-24/h4-5,8-10,13,20-21H,6-7,11-12H2,1-3H3,(H,26,27,28)/t20-,21+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289146
PNG
(US10093660, Example 1.18)
Show SMILES CS(C)(=O)=Nc1cc(Br)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)ncnc2c1
Show InChI InChI=1S/C20H20BrFN4O4S/c1-31(2,28)26-12-6-13(21)19-15(7-12)23-10-24-20(19)25-14-4-3-11(22)5-17(14)30-18-9-29-8-16(18)27/h3-7,10,16,18,27H,8-9H2,1-2H3,(H,23,24,25)/t16-,18-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289220
PNG
(US10093660, Example 2.41)
Show SMILES Cc1cc(cc2ncnc(Nc3cccnc3O[C@H]3COC[C@@H]3O)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C21H23N5O4S/c1-13-8-14(26-31(28)6-3-7-31)9-16-19(13)20(24-12-23-16)25-15-4-2-5-22-21(15)30-18-11-29-10-17(18)27/h2,4-5,8-9,12,17-18,27H,3,6-7,10-11H2,1H3,(H,23,24,25)/t17-,18-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289412
PNG
(US10093660, Example 14.4)
Show SMILES Cc1cc(cc2ncnc(Nc3cccnc3O[C@H]3COC[C@H]3O)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H25N5O4S/c1-14-9-15(27-32(29)7-2-3-8-32)10-17-20(14)21(25-13-24-17)26-16-5-4-6-23-22(16)31-19-12-30-11-18(19)28/h4-6,9-10,13,18-19,28H,2-3,7-8,11-12H2,1H3,(H,24,25,26)/t18-,19+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289178
PNG
(US10093660, Example 2.10)
Show SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C24H27FN4O4S/c1-15-9-17(29-34(30)7-3-4-8-34)11-19-23(15)24(27-14-26-19)28-18-6-5-16(25)10-20(18)33-22-13-32-12-21(22)31-2/h5-6,9-11,14,21-22H,3-4,7-8,12-13H2,1-2H3,(H,26,27,28)/t21-,22+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289248
PNG
(US10093660, Example 2.54)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(Cl)nc3O[C@@H]3COC[C@H]3O)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H24ClN5O4S/c1-13-8-14(28-33(30)6-2-3-7-33)9-16-20(13)21(25-12-24-16)26-15-4-5-19(23)27-22(15)32-18-11-31-10-17(18)29/h4-5,8-9,12,17-18,29H,2-3,6-7,10-11H2,1H3,(H,24,25,26)/t17-,18-/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289249
PNG
(US10093660, Example 2.55)
Show SMILES CS(C)(=O)=Nc1cc(F)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)ncnc2c1
Show InChI InChI=1S/C20H20F2N4O4S/c1-31(2,28)26-12-6-13(22)19-15(7-12)23-10-24-20(19)25-14-4-3-11(21)5-17(14)30-18-9-29-8-16(18)27/h3-7,10,16,18,27H,8-9H2,1-2H3,(H,23,24,25)/t16-,18-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289262
PNG
(US10093660, Example 2.66)
Show SMILES O[C@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H22F2N4O4S/c23-13-3-4-16(19(7-13)32-20-11-31-10-18(20)29)27-22-21-15(24)8-14(9-17(21)25-12-26-22)28-33(30)5-1-2-6-33/h3-4,7-9,12,18,20,29H,1-2,5-6,10-11H2,(H,25,26,27)/t18-,20-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289362
PNG
(US10093660, Example 8.2)
Show SMILES COc1cc(cc2ncnc(Nc3ccc(Cl)nc3O[C@H]3COC[C@@H]3O)c12)N=S(C)(C)=O
Show InChI InChI=1S/C20H22ClN5O5S/c1-29-15-7-11(26-32(2,3)28)6-13-18(15)19(23-10-22-13)24-12-4-5-17(21)25-20(12)31-16-9-30-8-14(16)27/h4-7,10,14,16,27H,8-9H2,1-3H3,(H,22,23,24)/t14-,16-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289398
PNG
(US10093660, Example 10.3)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@H]3OCC(F)F)c12)N=S(C)(C)=O
Show InChI InChI=1S/C23H25F3N4O4S/c1-13-6-15(30-35(2,3)31)8-17-22(13)23(28-12-27-17)29-16-5-4-14(24)7-18(16)34-20-10-32-9-19(20)33-11-21(25)26/h4-8,12,19-21H,9-11H2,1-3H3,(H,27,28,29)/t19-,20+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289404
PNG
(US10093660, Example 12.1)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OC3CCC(O)OC3)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H25FN4O4S/c1-14-9-16(28-33(30)7-2-8-33)11-19-22(14)23(26-13-25-19)27-18-5-3-15(24)10-20(18)32-17-4-6-21(29)31-12-17/h3,5,9-11,13,17,21,29H,2,4,6-8,12H2,1H3,(H,25,26,27)
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EVOTEC INTERNATONAL GMBH

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Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289197
PNG
(US10093660, Example 2.26)
Show SMILES Cc1cc(cc2ncnc(Nc3cccnc3O[C@H]3COC[C@H]3OCCF)c12)N=S(C)(C)=O
Show InChI InChI=1S/C22H26FN5O4S/c1-14-9-15(28-33(2,3)29)10-17-20(14)21(26-13-25-17)27-16-5-4-7-24-22(16)32-19-12-30-11-18(19)31-8-6-23/h4-5,7,9-10,13,18-19H,6,8,11-12H2,1-3H3,(H,25,26,27)/t18-,19+/m1/s1
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EVOTEC INTERNATONAL GMBH

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Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289213
PNG
(US10093660, Example 2.36)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C22H23FN4O4S/c1-13-7-15(27-32(29)5-2-6-32)9-17-21(13)22(25-12-24-17)26-16-4-3-14(23)8-19(16)31-20-11-30-10-18(20)28/h3-4,7-9,12,18,20,28H,2,5-6,10-11H2,1H3,(H,24,25,26)/t18-,20-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289315
PNG
(US10093660, Example 2.99)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3C[C@@H]4CO[C@H]3C4)c12)N=S(C)(C)=O
Show InChI InChI=1S/C23H25FN4O3S/c1-13-6-16(28-32(2,3)29)10-18-22(13)23(26-12-25-18)27-17-5-4-15(24)9-19(17)31-21-8-14-7-20(21)30-11-14/h4-6,9-10,12,14,20-21H,7-8,11H2,1-3H3,(H,25,26,27)/t14-,20+,21+/m1/s1
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EVOTEC INTERNATONAL GMBH

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Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289375
PNG
(US10093660, Example 9.10)
Show SMILES COc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3COC[C@@H]3O)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C22H23FN4O5S/c1-30-19-9-14(27-33(29)5-2-6-33)8-16-21(19)22(25-12-24-16)26-15-4-3-13(23)7-18(15)32-20-11-31-10-17(20)28/h3-4,7-9,12,17,20,28H,2,5-6,10-11H2,1H3,(H,24,25,26)/t17-,20-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289417
PNG
(US10093660, Example 14.9)
Show SMILES O[C@H]1COC[C@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H22ClFN4O4S/c23-15-8-14(28-33(30)5-1-2-6-33)9-17-21(15)22(26-12-25-17)27-16-4-3-13(24)7-19(16)32-20-11-31-10-18(20)29/h3-4,7-9,12,18,20,29H,1-2,5-6,10-11H2,(H,25,26,27)/t18-,20+/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289163
PNG
(US10093660, Example 1.34)
Show SMILES O[C@H]1COC[C@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C21H20ClFN4O4S/c22-14-7-13(27-32(29)4-1-5-32)8-16-20(14)21(25-11-24-16)26-15-3-2-12(23)6-18(15)31-19-10-30-9-17(19)28/h2-3,6-8,11,17,19,28H,1,4-5,9-10H2,(H,24,25,26)/t17-,19+/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289122
PNG
(US10093660, Example 1.3)
Show SMILES CS(C)(=O)=Nc1cc(Cl)c2c(Nc3ccc(F)cc3O[C@H]3COC[C@H]3O)ncnc2c1
Show InChI InChI=1S/C20H20ClFN4O4S/c1-31(2,28)26-12-6-13(21)19-15(7-12)23-10-24-20(19)25-14-4-3-11(22)5-17(14)30-18-9-29-8-16(18)27/h3-7,10,16,18,27H,8-9H2,1-2H3,(H,23,24,25)/t16-,18+/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289405
PNG
(US10093660, Example 12.2)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OC3CCC(O)OC3)c12)N=S(C)(C)=O
Show InChI InChI=1S/C22H25FN4O4S/c1-13-8-15(27-32(2,3)29)10-18-21(13)22(25-12-24-18)26-17-6-4-14(23)9-19(17)31-16-5-7-20(28)30-11-16/h4,6,8-10,12,16,20,28H,5,7,11H2,1-3H3,(H,24,25,26)
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289254
PNG
(US10093660, Example 2.60)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H]3CN(C[C@@H]3O)S(C)(=O)=O)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C24H28FN5O5S2/c1-15-9-17(29-37(34)7-3-4-8-37)11-19-23(15)24(27-14-26-19)28-18-6-5-16(25)10-21(18)35-22-13-30(12-20(22)31)36(2,32)33/h5-6,9-11,14,20,22,31H,3-4,7-8,12-13H2,1-2H3,(H,26,27,28)/t20-,22-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289180
PNG
(US10093660, Example 2.12)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@@H]3CN(C[C@H]3O)S(C)(=O)=O)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C24H28FN5O5S2/c1-15-9-17(29-37(34)7-3-4-8-37)11-19-23(15)24(27-14-26-19)28-18-6-5-16(25)10-21(18)35-22-13-30(12-20(22)31)36(2,32)33/h5-6,9-11,14,20,22,31H,3-4,7-8,12-13H2,1-2H3,(H,26,27,28)/t20-,22-/m1/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM289225
PNG
(US10093660, Example 2.43)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(Cl)nc3O[C@H]3COC[C@@H]3O)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C21H22ClN5O4S/c1-12-7-13(27-32(29)5-2-6-32)8-15-19(12)20(24-11-23-15)25-14-3-4-18(22)26-21(14)31-17-10-30-9-16(17)28/h3-4,7-8,11,16-17,28H,2,5-6,9-10H2,1H3,(H,23,24,25)/t16-,17-/m0/s1
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EVOTEC INTERNATONAL GMBH

US Patent


Assay Description
ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...


US Patent US10093660 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%