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Patent code US10098883

Compile Data Set for Download or QSAR
Found 105 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290292
PNG
(2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C#N)c3c2[nH]1
Show InChI InChI=1S/C16H15N5O/c17-9-11-2-1-3-12-15(11)16-19-14(22)8-13(21(16)20-12)10-4-6-18-7-5-10/h1-3,8,10,18H,4-7H2,(H,19,22)
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n/an/a 10n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290334
PNG
(9-Fluoro-10-phenyl-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1-c1ccccc1)C1CCNCC1
Show InChI InChI=1S/C21H19FN4O/c22-15-6-7-16-20(19(15)14-4-2-1-3-5-14)21-24-18(27)12-17(26(21)25-16)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)
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n/an/a 11n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290336
PNG
(10-Chloro-8-methyl-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Cc1cc(Cl)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H17ClN4O/c1-9-6-11(17)15-12(7-9)20-21-13(8-14(22)19-16(15)21)10-2-4-18-5-3-10/h6-8,10,18H,2-5H2,1H3,(H,19,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290309
PNG
((−)-trans-10-Ethoxy-4-(2-methylpiperidin-4-y...)
Show SMILES CCOc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNC(C)C1
Show InChI InChI=1S/C18H22N4O2/c1-3-24-15-6-4-5-13-17(15)18-20-16(23)10-14(22(18)21-13)12-7-8-19-11(2)9-12/h4-6,10-12,19H,3,7-9H2,1-2H3,(H,20,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290324
PNG
(4-(Piperidin-4-yl)-10-[2-(trifluoromethyl)phenyl]p...)
Show SMILES FC(F)(F)c1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-27-19(30)12-18(29(21)28-17)13-8-10-26-11-9-13/h1-7,12-13,26H,8-11H2,(H,27,30)
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n/an/a 13n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290314
PNG
(10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H19FN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290286
PNG
(7-Bromo-4-(piperidin-4-yl)pyrido[4′,3′...)
Show SMILES Brc1cncc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C14H14BrN5O/c15-10-7-17-6-9-13(10)19-20-11(5-12(21)18-14(9)20)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290320
PNG
(10-Cyclopentyl-4-(piperidin-4-yl)pyrimido[1,2-b]in...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C4CCCC4)c3c2[nH]1
Show InChI InChI=1S/C20H24N4O/c25-18-12-17(14-8-10-21-11-9-14)24-20(22-18)19-15(13-4-1-2-5-13)6-3-7-16(19)23-24/h3,6-7,12-14,21H,1-2,4-5,8-11H2,(H,22,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290269
PNG
(10-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Brc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290312
PNG
(4-(Piperidin-4-yl)-10-[4-(trifluoromethyl)phenyl]p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)15-6-4-13(5-7-15)16-2-1-3-17-20(16)21-27-19(30)12-18(29(21)28-17)14-8-10-26-11-9-14/h1-7,12,14,26H,8-11H2,(H,27,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290329
PNG
(10-sec-Butyl-4-(piperidin-4-yl)pyrimido[1,2-b]inda...)
Show SMILES CCC(C)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C19H24N4O/c1-3-12(2)14-5-4-6-15-18(14)19-21-17(24)11-16(23(19)22-15)13-7-9-20-10-8-13/h4-6,11-13,20H,3,7-10H2,1-2H3,(H,21,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290307
PNG
((−)-trans-10-Bromo-4-(2-methylpiperidin-4-yl...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Br)cccc3nn12
Show InChI InChI=1S/C16H17BrN4O/c1-9-7-10(5-6-18-9)13-8-14(22)19-16-15-11(17)3-2-4-12(15)20-21(13)16/h2-4,8-10,18H,5-7H2,1H3,(H,19,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290313
PNG
(10-Phenyl-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccccc4)c3c2[nH]1
Show InChI InChI=1S/C21H20N4O/c26-19-13-18(15-9-11-22-12-10-15)25-21(23-19)20-16(7-4-8-17(20)24-25)14-5-2-1-3-6-14/h1-8,13,15,22H,9-12H2,(H,23,26)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290331
PNG
(10-Bromo-9-methyl-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Cc1ccc2nn3c(cc(=O)[nH]c3c2c1Br)C1CCNCC1
Show InChI InChI=1S/C16H17BrN4O/c1-9-2-3-11-14(15(9)17)16-19-13(22)8-12(21(16)20-11)10-4-6-18-7-5-10/h2-3,8,10,18H,4-7H2,1H3,(H,19,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290315
PNG
(4-(Piperidin-4-yl)-10-(pyridin-3-yl)pyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4cccnc4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-18-11-17(13-6-9-21-10-7-13)25-20(23-18)19-15(4-1-5-16(19)24-25)14-3-2-8-22-12-14/h1-5,8,11-13,21H,6-7,9-10H2,(H,23,26)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290308
PNG
((−)-trans-4-(2-Methylpiperidin-4-yl)-10-phen...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(ccnc3nn12)-c1ccccc1
Show InChI InChI=1S/C21H21N5O/c1-13-11-15(7-9-22-13)17-12-18(27)24-21-19-16(14-5-3-2-4-6-14)8-10-23-20(19)25-26(17)21/h2-6,8,10,12-13,15,22H,7,9,11H2,1H3,(H,24,27)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290328
PNG
(10-Bromo-7-fluoro-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Fc1ccc(Br)c2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H14BrFN4O/c16-9-1-2-10(17)14-13(9)15-19-12(22)7-11(21(15)20-14)8-3-5-18-6-4-8/h1-2,7-8,18H,3-6H2,(H,19,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290333
PNG
(10-Isopropoxy-4-(piperidin-4-yl)pyrimido[1,2-b]ind...)
Show SMILES CC(C)Oc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C18H22N4O2/c1-11(2)24-15-5-3-4-13-17(15)18-20-16(23)10-14(22(18)21-13)12-6-8-19-9-7-12/h3-5,10-12,19H,6-9H2,1-2H3,(H,20,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290335
PNG
(10-(2,6-Difluorophenyl)-4-(piperidin-4-yl)pyrimido...)
Show SMILES Fc1cccc(F)c1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H18F2N4O/c22-14-4-2-5-15(23)19(14)13-3-1-6-16-20(13)21-25-18(28)11-17(27(21)26-16)12-7-9-24-10-8-12/h1-6,11-12,24H,7-10H2,(H,25,28)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290262
PNG
(10-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Clc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290311
PNG
(10-(4-Methoxyphenyl)-4-(piperidin-4-yl)pyrimido[1,...)
Show SMILES COc1ccc(cc1)-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H22N4O2/c1-28-16-7-5-14(6-8-16)17-3-2-4-18-21(17)22-24-20(27)13-19(26(22)25-18)15-9-11-23-12-10-15/h2-8,13,15,23H,9-12H2,1H3,(H,24,27)
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n/an/a 15n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290343
PNG
(10-(1-Methyl-1H-pyrazol-5-yl)-4-(piperidin-4-yl)py...)
Show SMILES Cn1nccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C19H20N6O/c1-24-15(7-10-21-24)13-3-2-4-14-18(13)19-22-17(26)11-16(25(19)23-14)12-5-8-20-9-6-12/h2-4,7,10-12,20H,5-6,8-9H2,1H3,(H,22,26)
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n/an/a 15n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290338
PNG
(10-Bromo-8-fluoro-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Fc1cc(Br)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H14BrFN4O/c16-10-5-9(17)6-11-14(10)15-19-13(22)7-12(21(15)20-11)8-1-3-18-4-2-8/h5-8,18H,1-4H2,(H,19,22)
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n/an/a 16n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290316
PNG
(4-(Piperidin-4-yl)-10-(pyridin-4-yl)pyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccncc4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-18-12-17(14-6-10-22-11-7-14)25-20(23-18)19-15(2-1-3-16(19)24-25)13-4-8-21-9-5-13/h1-5,8-9,12,14,22H,6-7,10-11H2,(H,23,26)
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n/an/a 16n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290332
PNG
(10-Bromo-7-methyl-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Cc1ccc(Br)c2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H17BrN4O/c1-9-2-3-11(17)14-15(9)20-21-12(8-13(22)19-16(14)21)10-4-6-18-7-5-10/h2-3,8,10,18H,4-7H2,1H3,(H,19,22)
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n/an/a 16n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290303
PNG
(10-Phenyl-4-(piperidin-4-yl)pyrido[2′,3̸...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nccc(-c4ccccc4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-17-12-16(14-6-9-21-10-7-14)25-20(23-17)18-15(8-11-22-19(18)24-25)13-4-2-1-3-5-13/h1-5,8,11-12,14,21H,6-7,9-10H2,(H,23,26)
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n/an/a 17n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290337
PNG
(4-(Piperidin-4-yl)-10-[2-(trifluoromethoxy)phenyl]...)
Show SMILES FC(F)(F)Oc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)31-18-7-2-1-4-14(18)15-5-3-6-16-20(15)21-27-19(30)12-17(29(21)28-16)13-8-10-26-11-9-13/h1-7,12-13,26H,8-11H2,(H,27,30)
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n/an/a 18n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290319
PNG
(10-Isopropyl-4-(piperidin-4-yl)pyrimido[1,2-b]inda...)
Show SMILES CC(C)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C18H22N4O/c1-11(2)13-4-3-5-14-17(13)18-20-16(23)10-15(22(18)21-14)12-6-8-19-9-7-12/h3-5,10-12,19H,6-9H2,1-2H3,(H,20,23)
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n/an/a 18n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290293
PNG
(10-Methyl-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Cc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H18N4O/c1-10-3-2-4-12-15(10)16-18-14(21)9-13(20(16)19-12)11-5-7-17-8-6-11/h2-4,9,11,17H,5-8H2,1H3,(H,18,21)
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n/an/a 18n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290314
PNG
(10-(2-Fluorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES Fc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H19FN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)
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n/an/a 18n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290342
PNG
(10-(2-Methylphenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES Cc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H22N4O/c1-14-5-2-3-6-16(14)17-7-4-8-18-21(17)22-24-20(27)13-19(26(22)25-18)15-9-11-23-12-10-15/h2-8,13,15,23H,9-12H2,1H3,(H,24,27)
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n/an/a 18n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290321
PNG
(10-(2-Chlorophenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES Clc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H19ClN4O/c22-16-6-2-1-4-14(16)15-5-3-7-17-20(15)21-24-19(27)12-18(26(21)25-17)13-8-10-23-11-9-13/h1-7,12-13,23H,8-11H2,(H,24,27)
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n/an/a 19n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290339
PNG
(4-(Piperidin-4-yl)-10-(pyridin-2-yl)pyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccccn4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-18-12-17(13-7-10-21-11-8-13)25-20(23-18)19-14(4-3-6-16(19)24-25)15-5-1-2-9-22-15/h1-6,9,12-13,21H,7-8,10-11H2,(H,23,26)
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n/an/a 20n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290326
PNG
(10-Chloro-9-methyl-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Cc1ccc2nn3c(cc(=O)[nH]c3c2c1Cl)C1CCNCC1
Show InChI InChI=1S/C16H17ClN4O/c1-9-2-3-11-14(15(9)17)16-19-13(22)8-12(21(16)20-11)10-4-6-18-7-5-10/h2-3,8,10,18H,4-7H2,1H3,(H,19,22)
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n/an/a 20n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290284
PNG
(3-Fluoro-7-(piperidin-4-yl)pyrido[3′,2′...)
Show SMILES Fc1cnc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C14H14FN5O/c15-9-5-10-13(17-7-9)14-18-12(21)6-11(20(14)19-10)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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n/an/a 21n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290292
PNG
(2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C#N)c3c2[nH]1
Show InChI InChI=1S/C16H15N5O/c17-9-11-2-1-3-12-15(11)16-19-14(22)8-13(21(16)20-12)10-4-6-18-7-5-10/h1-3,8,10,18H,4-7H2,(H,19,22)
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n/an/a 21n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290276
PNG
(3,4-Dimethyl-8-(piperidin-4-yl)pyrimido[1′,2...)
Show SMILES Cc1nnc2nn3c(cc(=O)[nH]c3c2c1C)C1CCNCC1
Show InChI InChI=1S/C15H18N6O/c1-8-9(2)18-19-14-13(8)15-17-12(22)7-11(21(15)20-14)10-3-5-16-6-4-10/h7,10,16H,3-6H2,1-2H3,(H,17,22)
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n/an/a 22n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290279
PNG
(10-Iodo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Ic1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15IN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 22n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290298
PNG
(10-Chloro-4-(piperidin-4-yl)-8-(trifluoromethyl)py...)
Show SMILES FC(F)(F)c1cc(Cl)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H14ClF3N4O/c17-10-5-9(16(18,19)20)6-11-14(10)15-22-13(25)7-12(24(15)23-11)8-1-3-21-4-2-8/h5-8,21H,1-4H2,(H,22,25)
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n/an/a 23n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290341
PNG
(4-(Piperidin-4-yl)-10-(3-thienyl)pyrimido[1,2-b]in...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccsc4)c3c2[nH]1
Show InChI InChI=1S/C19H18N4OS/c24-17-10-16(12-4-7-20-8-5-12)23-19(21-17)18-14(13-6-9-25-11-13)2-1-3-15(18)22-23/h1-3,6,9-12,20H,4-5,7-8H2,(H,21,24)
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n/an/a 23n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290330
PNG
(10-Isobutyl-4-(piperidin-4-yl)pyrimido[1,2-b]indaz...)
Show SMILES CC(C)Cc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C19H24N4O/c1-12(2)10-14-4-3-5-15-18(14)19-21-17(24)11-16(23(19)22-15)13-6-8-20-9-7-13/h3-5,11-13,20H,6-10H2,1-2H3,(H,21,24)
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n/an/a 23n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290347
PNG
(10-Chloro-9-fluoro-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1Cl)C1CCNCC1
Show InChI InChI=1S/C15H14ClFN4O/c16-14-9(17)1-2-10-13(14)15-19-12(22)7-11(21(15)20-10)8-3-5-18-6-4-8/h1-2,7-8,18H,3-6H2,(H,19,22)
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n/an/a 24n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290304
PNG
(10-methyl-4-(piperidin-4-yl)pyrido[2′,3̸...)
Show SMILES Cc1ccnc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H17N5O/c1-9-2-7-17-14-13(9)15-18-12(21)8-11(20(15)19-14)10-3-5-16-6-4-10/h2,7-8,10,16H,3-6H2,1H3,(H,18,21)
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n/an/a 24n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290318
PNG
(10-Cyclopropyl-4-(piperidin-4-yl)pyrimido[1,2-b]in...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C4CC4)c3c2[nH]1
Show InChI InChI=1S/C18H20N4O/c23-16-10-15(12-6-8-19-9-7-12)22-18(20-16)17-13(11-4-5-11)2-1-3-14(17)21-22/h1-3,10-12,19H,4-9H2,(H,20,23)
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n/an/a 24n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290296
PNG
(8-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 24n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290344
PNG
(10-(1-Methyl-1H-pyrazol-4-yl)-4-(piperidin-4-yl)py...)
Show SMILES Cn1cc(cn1)-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C19H20N6O/c1-24-11-13(10-21-24)14-3-2-4-15-18(14)19-22-17(26)9-16(25(19)23-15)12-5-7-20-8-6-12/h2-4,9-12,20H,5-8H2,1H3,(H,22,26)
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n/an/a 25n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290325
PNG
((−)-trans-10-Chloro-4-(2-methylpiperidin-4-y...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Cl)cccc3nn12
Show InChI InChI=1S/C16H17ClN4O/c1-9-7-10(5-6-18-9)13-8-14(22)19-16-15-11(17)3-2-4-12(15)20-21(13)16/h2-4,8-10,18H,5-7H2,1H3,(H,19,22)
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n/an/a 25n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290322
PNG
(10-(2-Methoxyphenyl)-4-(piperidin-4-yl)pyrimido[1,...)
Show SMILES COc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H22N4O2/c1-28-19-8-3-2-5-15(19)16-6-4-7-17-21(16)22-24-20(27)13-18(26(22)25-17)14-9-11-23-12-10-14/h2-8,13-14,23H,9-12H2,1H3,(H,24,27)
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n/an/a 25n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290353
PNG
(4-(Piperidin-4-yl)-10-(1H-pyrazol-1-yl)pyrimido[1,...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-n4cccn4)c3c2[nH]1
Show InChI InChI=1S/C18H18N6O/c25-16-11-15(12-5-8-19-9-6-12)24-18(21-16)17-13(22-24)3-1-4-14(17)23-10-2-7-20-23/h1-4,7,10-12,19H,5-6,8-9H2,(H,21,25)
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n/an/a 26n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290278
PNG
(9-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Brc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 26n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290270
PNG
(4-(Piperidin-4-yl)-8-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-1-2-11-12(7-10)22-23-13(8-14(24)21-15(11)23)9-3-5-20-6-4-9/h1-2,7-9,20H,3-6H2,(H,21,24)
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n/an/a 26n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290345
PNG
(4-(Piperidin-4-yl)-10-(2-thienyl)pyrimido[1,2-b]in...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4cccs4)c3c2[nH]1
Show InChI InChI=1S/C19H18N4OS/c24-17-11-15(12-6-8-20-9-7-12)23-19(21-17)18-13(16-5-2-10-25-16)3-1-4-14(18)22-23/h1-5,10-12,20H,6-9H2,(H,21,24)
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n/an/a 26n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290281
PNG
(7-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-11-3-1-2-10-14(11)19-20-12(8-13(21)18-15(10)20)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 26n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290348
PNG
(4-(Piperidin-4-yl)-10-(1H-1,2,4-triazol-1-yl)pyrim...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-n4cncn4)c3c2[nH]1
Show InChI InChI=1S/C17H17N7O/c25-15-8-14(11-4-6-18-7-5-11)24-17(21-15)16-12(22-24)2-1-3-13(16)23-10-19-9-20-23/h1-3,8-11,18H,4-7H2,(H,21,25)
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n/an/a 27n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290355
PNG
(4-(Piperidin-4-yl)-10-(2H-1,2,3-triazol-2-yl)pyrim...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-n4nccn4)c3c2[nH]1
Show InChI InChI=1S/C17H17N7O/c25-15-10-14(11-4-6-18-7-5-11)23-17(21-15)16-12(22-23)2-1-3-13(16)24-19-8-9-20-24/h1-3,8-11,18H,4-7H2,(H,21,25)
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n/an/a 27n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290349
PNG
(9-Fluoro-10-(2-fluorophenyl)-4-(piperidin-4-yl)pyr...)
Show SMILES Fc1ccccc1-c1c(F)ccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C21H18F2N4O/c22-14-4-2-1-3-13(14)19-15(23)5-6-16-20(19)21-25-18(28)11-17(27(21)26-16)12-7-9-24-10-8-12/h1-6,11-12,24H,7-10H2,(H,25,28)
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n/an/a 27n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290288
PNG
(4-(Piperidin-4-yl)pyrido[3′,4′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cnccc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-13-7-12(9-1-4-15-5-2-9)19-14(17-13)10-3-6-16-8-11(10)18-19/h3,6-9,15H,1-2,4-5H2,(H,17,20)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290262
PNG
(10-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Clc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290350
PNG
(10-(2-Ethoxyphenyl)-4-(piperidin-4-yl)pyrimido[1,2...)
Show SMILES CCOc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C23H24N4O2/c1-2-29-20-9-4-3-6-16(20)17-7-5-8-18-22(17)23-25-21(28)14-19(27(23)26-18)15-10-12-24-13-11-15/h3-9,14-15,24H,2,10-13H2,1H3,(H,25,28)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290263
PNG
(10-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Fc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290282
PNG
(8,10-Difluoro-4-(piperidin-4-yl)pyrimido[1,2-b]ind...)
Show SMILES Fc1cc(F)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H14F2N4O/c16-9-5-10(17)14-11(6-9)20-21-12(7-13(22)19-15(14)21)8-1-3-18-4-2-8/h5-8,18H,1-4H2,(H,19,22)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290356
PNG
(4-(Piperidin-4-yl)-10-(1H-1,2,3-triazol-1-yl)pyrim...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-n4ccnn4)c3c2[nH]1
Show InChI InChI=1S/C17H17N7O/c25-15-10-14(11-4-6-18-7-5-11)24-17(20-15)16-12(21-24)2-1-3-13(16)23-9-8-19-22-23/h1-3,8-11,18H,4-7H2,(H,20,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290285
PNG
(10-Ethoxy-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES CCOc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C17H20N4O2/c1-2-23-14-5-3-4-12-16(14)17-19-15(22)10-13(21(17)20-12)11-6-8-18-9-7-11/h3-5,10-11,18H,2,6-9H2,1H3,(H,19,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290280
PNG
(8-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Brc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 30n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290357
PNG
(10-Chloro-7-methyl-4-(piperidin-4-yl)pyrimido[1,2-...)
Show SMILES Cc1ccc(Cl)c2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H17ClN4O/c1-9-2-3-11(17)14-15(9)20-21-12(8-13(22)19-16(14)21)10-4-6-18-7-5-10/h2-3,8,10,18H,4-7H2,1H3,(H,19,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290261
PNG
(4-(Piperidin-4-yl)-9-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-1-2-12-11(7-10)15-21-14(24)8-13(23(15)22-12)9-3-5-20-6-4-9/h1-2,7-9,20H,3-6H2,(H,21,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290354
PNG
(10-(2-Fluoro-6-methoxyphenyl)-4-(piperidin-4-yl)py...)
Show SMILES COc1cccc(F)c1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C22H21FN4O2/c1-29-18-7-3-5-15(23)20(18)14-4-2-6-16-21(14)22-25-19(28)12-17(27(22)26-16)13-8-10-24-11-9-13/h2-7,12-13,24H,8-11H2,1H3,(H,25,28)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290272
PNG
(8-tert-Butyl-4-(piperidin-4-yl)pyrido[2′,3&#...)
Show SMILES CC(C)(C)c1ccc2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C18H23N5O/c1-18(2,3)14-5-4-12-16(20-14)22-23-13(10-15(24)21-17(12)23)11-6-8-19-9-7-11/h4-5,10-11,19H,6-9H2,1-3H3,(H,21,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290271
PNG
(4-(Piperidin-4-yl)-10-(trifluoromethyl)pyrimido[1,...)
Show SMILES FC(F)(F)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-2-1-3-11-14(10)15-21-13(24)8-12(23(15)22-11)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
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n/an/a 32n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290287
PNG
(7-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-11-3-1-2-10-14(11)19-20-12(8-13(21)18-15(10)20)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 33n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290269
PNG
(10-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Brc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 34n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290283
PNG
(8-Methyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES Cc1ccc2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C15H17N5O/c1-9-2-3-11-14(17-9)19-20-12(8-13(21)18-15(11)20)10-4-6-16-7-5-10/h2-3,8,10,16H,4-7H2,1H3,(H,18,21)
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n/an/a 34n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290363
PNG
(4-(piperidin-4-yl)-10-(2,2,2-trifluoroethoxy)pyrim...)
Show SMILES FC(F)(F)COc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C17H17F3N4O2/c18-17(19,20)9-26-13-3-1-2-11-15(13)16-22-14(25)8-12(24(16)23-11)10-4-6-21-7-5-10/h1-3,8,10,21H,4-7,9H2,(H,22,25)
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n/an/a 34n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290275
PNG
(8-Amino-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Nc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H17N5O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6,16H2,(H,18,21)
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n/an/a 34n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290364
PNG
(10-amino-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Nc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H17N5O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7,16H2,(H,18,21)
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n/an/a 35n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290351
PNG
(10-(2-Isopropoxyphenyl)-4-(piperidin-4-yl)pyrimido...)
Show SMILES CC(C)Oc1ccccc1-c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C24H26N4O2/c1-15(2)30-21-9-4-3-6-17(21)18-7-5-8-19-23(18)24-26-22(29)14-20(28(24)27-19)16-10-12-25-13-11-16/h3-9,14-16,25H,10-13H2,1-2H3,(H,26,29)
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n/an/a 35n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290360
PNG
(4-(piperidin-4-yl)-10-(1H-pyrrol-2-yl)pyrimido[1,2...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4ccc[nH]4)c3c2[nH]1
Show InChI InChI=1S/C19H19N5O/c25-17-11-16(12-6-9-20-10-7-12)24-19(22-17)18-13(14-5-2-8-21-14)3-1-4-15(18)23-24/h1-5,8,11-12,20-21H,6-7,9-10H2,(H,22,25)
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n/an/a 35n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290358
PNG
((+)-Cis-10-Chloro-4-(2-methylpiperidin-4-yl)pyrimi...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Cl)cccc3nn12
Show InChI InChI=1S/C16H17ClN4O/c1-9-7-10(5-6-18-9)13-8-14(22)19-16-15-11(17)3-2-4-12(15)20-21(13)16/h2-4,8-10,18H,5-7H2,1H3,(H,19,22)
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n/an/a 35n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290327
PNG
(10-Bromo-9-fluoro-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1Br)C1CCNCC1
Show InChI InChI=1S/C15H14BrFN4O/c16-14-9(17)1-2-10-13(14)15-19-12(22)7-11(21(15)20-10)8-3-5-18-6-4-8/h1-2,7-8,18H,3-6H2,(H,19,22)
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n/an/a 35n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290346
PNG
(10-Bromo-8-methyl-4-(piperidin-4-yl)pyrimido[1,2-b...)
Show SMILES Cc1cc(Br)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H17BrN4O/c1-9-6-11(17)15-12(7-9)20-21-13(8-14(22)19-16(15)21)10-2-4-18-5-3-10/h6-8,10,18H,2-5H2,1H3,(H,19,22)
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n/an/a 36n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290306
PNG
(4-(Piperidin-4-yl)pyrido[4′,3′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ccncc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-13-7-12(9-1-4-15-5-2-9)19-14(17-13)10-8-16-6-3-11(10)18-19/h3,6-9,15H,1-2,4-5H2,(H,17,20)
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n/an/a 36n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290305
PNG
(9-Iodo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2(...)
Show SMILES Ic1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15IN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 36n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290268
PNG
(7-(Piperidin-4-yl)pyrido[3′,2′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccnc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-12-8-11(9-3-6-15-7-4-9)19-14(17-12)13-10(18-19)2-1-5-16-13/h1-2,5,8-9,15H,3-4,6-7H2,(H,17,20)
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n/an/a 36n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290302
PNG
(9-Phenyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ncc(cc3c2[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H19N5O/c26-18-11-17(14-6-8-21-9-7-14)25-20(23-18)16-10-15(12-22-19(16)24-25)13-4-2-1-3-5-13/h1-5,10-12,14,21H,6-9H2,(H,23,26)
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n/an/a 37n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290264
PNG
(9-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 37n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290277
PNG
(8-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 38n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290297
PNG
(10-(Dimethylamino)-4-(piperidin-4-yl)pyrido[2̸...)
Show SMILES CN(C)c1ccnc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H20N6O/c1-21(2)11-5-8-18-15-14(11)16-19-13(23)9-12(22(16)20-15)10-3-6-17-7-4-10/h5,8-10,17H,3-4,6-7H2,1-2H3,(H,19,23)
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n/an/a 38n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290340
PNG
(4-(Piperidin-4-yl)-10-(1,3-thiazol-2-yl)pyrimido[1...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4nccs4)c3c2[nH]1
Show InChI InChI=1S/C18H17N5OS/c24-15-10-14(11-4-6-19-7-5-11)23-17(21-15)16-12(18-20-8-9-25-18)2-1-3-13(16)22-23/h1-3,8-11,19H,4-7H2,(H,21,24)
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n/an/a 41n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290294
PNG
(4-(Piperidin-4-yl)-10-(trifluoromethoxy)pyrimido[1...)
Show SMILES FC(F)(F)Oc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O2/c17-16(18,19)25-12-3-1-2-10-14(12)15-21-13(24)8-11(23(15)22-10)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
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n/an/a 44n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290267
PNG
(10-Methoxy-4-(piperidin-4-yl)pyrimido[1,2-b]indazo...)
Show SMILES COc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H18N4O2/c1-22-13-4-2-3-11-15(13)16-18-14(21)9-12(20(16)19-11)10-5-7-17-8-6-10/h2-4,9-10,17H,5-8H2,1H3,(H,18,21)
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n/an/a 46n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290289
PNG
(4-(Piperidin-4-yl)-7-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)11-3-1-2-10-14(11)22-23-12(8-13(24)21-15(10)23)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
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n/an/a 46n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290301
PNG
(8-Phenyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nc(ccc3c2[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H19N5O/c26-18-12-17(14-8-10-21-11-9-14)25-20(23-18)15-6-7-16(22-19(15)24-25)13-4-2-1-3-5-13/h1-7,12,14,21H,8-11H2,(H,23,26)
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n/an/a 48n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290274
PNG
(9-Methyl-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Cc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C16H18N4O/c1-10-2-3-13-12(8-10)16-18-15(21)9-14(20(16)19-13)11-4-6-17-7-5-11/h2-3,8-9,11,17H,4-7H2,1H3,(H,18,21)
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n/an/a 48n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290273
PNG
(10-Methyl-4-(piperidin-4-yl)-8-(trifluoromethyl)py...)
Show SMILES Cc1cc(cc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N4O/c1-9-6-11(17(18,19)20)7-12-15(9)16-22-14(25)8-13(24(16)23-12)10-2-4-21-5-3-10/h6-8,10,21H,2-5H2,1H3,(H,22,25)
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n/an/a 50n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290260
PNG
(4-(Piperidin-4-yl)pyrimido[1,2-b]indazol-2(1H)-one...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ccccc3c2[nH]1
Show InChI InChI=1S/C15H16N4O/c20-14-9-13(10-5-7-16-8-6-10)19-15(17-14)11-3-1-2-4-12(11)18-19/h1-4,9-10,16H,5-8H2,(H,17,20)
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n/an/a 51n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290295
PNG
(7-(Piperidin-4-yl)pyrazino[2′,3′:3,4]p...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nccnc3c2[nH]1
Show InChI InChI=1S/C13H14N6O/c20-10-7-9(8-1-3-14-4-2-8)19-13(17-10)11-12(18-19)16-6-5-15-11/h5-8,14H,1-4H2,(H,17,20)
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n/an/a 60n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290361
PNG
(10-hydroxy-4-(piperidin-4-yl)pyrimido[1,2-b]indazo...)
Show SMILES Oc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H16N4O2/c20-12-3-1-2-10-14(12)15-17-13(21)8-11(19(15)18-10)9-4-6-16-7-5-9/h1-3,8-9,16,20H,4-7H2,(H,17,21)
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US Patent
n/an/a 74n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290265
PNG
(7,9-Dichloro-4-(piperidin-4-yl)pyrimido[1,2-b]inda...)
Show SMILES Clc1cc(Cl)c2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H14Cl2N4O/c16-9-5-10-14(11(17)6-9)20-21-12(7-13(22)19-15(10)21)8-1-3-18-4-2-8/h5-8,18H,1-4H2,(H,19,22)
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n/an/a 94n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290266
PNG
(9-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 95n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290290
PNG
(10-Nitro-4-(piperidin-4-yl)-8-(trifluoromethyl)pyr...)
Show SMILES [O-][N+](=O)c1cc(cc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1)C(F)(F)F
Show InChI InChI=1S/C16H14F3N5O3/c17-16(18,19)9-5-10-14(12(6-9)24(26)27)15-21-13(25)7-11(23(15)22-10)8-1-3-20-4-2-8/h5-8,20H,1-4H2,(H,21,25)
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n/an/a 97n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290300
PNG
(10-Bromo-4-(piperidin-4-yl)pyrido[3′,4′...)
Show SMILES Brc1cncc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C14H14BrN5O/c15-9-6-17-7-10-13(9)14-18-12(21)5-11(20(14)19-10)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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n/an/a 100n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290359
PNG
(10-(1H-imidazol-5-yl)-4-(piperidin-4-yl)pyrimido[1...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(-c4cnc[nH]4)c3c2[nH]1
Show InChI InChI=1S/C18H18N6O/c25-16-8-15(11-4-6-19-7-5-11)24-18(22-16)17-12(14-9-20-10-21-14)2-1-3-13(17)23-24/h1-3,8-11,19H,4-7H2,(H,20,21)(H,22,25)
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n/an/a 110n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290299
PNG
(8-(4-Fluorophenyl)-4-(piperidin-4-yl)-10-(trifluor...)
Show SMILES Fc1ccc(cc1)-c1cc(c2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1)C(F)(F)F
Show InChI InChI=1S/C21H17F4N5O/c22-13-3-1-11(2-4-13)15-9-14(21(23,24)25)18-19(27-15)29-30-16(10-17(31)28-20(18)30)12-5-7-26-8-6-12/h1-4,9-10,12,26H,5-8H2,(H,28,31)
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n/an/a 110n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290291
PNG
(8,10-Dimethyl-4-(piperidin-4-yl)pyrido[2′,3&...)
Show SMILES Cc1cc(C)c2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C16H19N5O/c1-9-7-10(2)18-15-14(9)16-19-13(22)8-12(21(16)20-15)11-3-5-17-6-4-11/h7-8,11,17H,3-6H2,1-2H3,(H,19,22)
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n/an/a 210n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290362
PNG
(2-oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...)
Show SMILES OC(=O)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H16N4O3/c21-13-8-12(9-4-6-17-7-5-9)20-15(18-13)14-10(16(22)23)2-1-3-11(14)19-20/h1-3,8-9,17H,4-7H2,(H,18,21)(H,22,23)
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US Patent
n/an/a 420n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%