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Patent code US10100045

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292057
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-cyclobutyl-5-(trifl...)
Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc(Cl)c4[nH]ncc4c3)c2n1
Show InChI InChI=1S/C18H13ClF3N5/c19-12-7-9(6-10-8-23-25-15(10)12)17-16-13(26-27(17)11-2-1-3-11)4-5-14(24-16)18(20,21)22/h4-8,11H,1-3H2,(H,23,25)
PDB

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UniChem
US Patent
n/an/a 0.0200n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292056
PNG
(2-Cyclobutyl-3-(7-methyl-1H-indazol-5-yl)-5-(trifl...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1
Show InChI InChI=1S/C19H16F3N5/c1-10-7-11(8-12-9-23-25-16(10)12)18-17-14(26-27(18)13-3-2-4-13)5-6-15(24-17)19(20,21)22/h5-9,13H,2-4H2,1H3,(H,23,25)
PDB

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UniChem
US Patent
n/an/a 0.0200n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292055
PNG
(7-Chloro-5-(2-cyclobutyl-5-(trifluoromethyl)-2H-py...)
Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1
Show InChI InChI=1S/C19H14ClF3N4O/c20-12-7-10(6-9-8-15(28)25-16(9)12)18-17-13(26-27(18)11-2-1-3-11)4-5-14(24-17)19(21,22)23/h4-7,11H,1-3,8H2,(H,25,28)
PDB

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UniChem
US Patent
n/an/a 0.0320n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292054
PNG
(5-(2-Cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1
Show InChI InChI=1S/C20H17F3N4O/c1-10-7-12(8-11-9-16(28)25-17(10)11)19-18-14(26-27(19)13-3-2-4-13)5-6-15(24-18)20(21,22)23/h5-8,13H,2-4,9H2,1H3,(H,25,28)
PDB

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US Patent
n/an/a 0.0500n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292053
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-5-(triflu...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)26-16(9-5-10-7-22-24-14(10)11(18)6-9)15-12(25-26)3-4-13(23-15)17(19,20)21/h3-8H,1-2H3,(H,22,24)
PDB

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UniChem
US Patent
n/an/a 0.0630n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292061
PNG
(5-(Difluoromethyl)-2-isopropyl-3-(7-methyl-1H-inda...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)F
Show InChI InChI=1S/C18H17F2N5/c1-9(2)25-17(11-6-10(3)15-12(7-11)8-21-23-15)16-13(24-25)4-5-14(22-16)18(19)20/h4-9,18H,1-3H3,(H,21,23)
PDB

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US Patent
n/an/a 0.100n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292037
PNG
(2-Cyclopentyl-3-(7-methyl-1H-indazol-5-yl)-5-(trif...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCCC1
Show InChI InChI=1S/C20H18F3N5/c1-11-8-12(9-13-10-24-26-17(11)13)19-18-15(6-7-16(25-18)20(21,22)23)27-28(19)14-4-2-3-5-14/h6-10,14H,2-5H2,1H3,(H,24,26)
PDB

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UniChem
US Patent
n/an/a 0.126n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292065
PNG
(5,7-Bis(difluoromethyl)-2-isopropyl-3-(7-methyl-1H...)
Show SMILES CC(C)n1nc2c(cc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)F)C(F)F
Show InChI InChI=1S/C19H17F4N5/c1-8(2)28-17(10-4-9(3)14-11(5-10)7-24-26-14)16-15(27-28)12(18(20)21)6-13(25-16)19(22)23/h4-8,18-19H,1-3H3,(H,24,26)
PDB

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UniChem
US Patent
n/an/a 0.158n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292051
PNG
(7-Chloro-5-(2-isopropyl-5-(trifluoromethyl)-2H-pyr...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N4O/c1-8(2)26-17(10-5-9-7-14(27)24-15(9)11(19)6-10)16-12(25-26)3-4-13(23-16)18(20,21)22/h3-6,8H,7H2,1-2H3,(H,24,27)
PDB

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UniChem
US Patent
n/an/a 0.251n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292052
PNG
(2-Isopropyl-3-(7-methyl-1H-indazol-5-yl)-5-(triflu...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C18H16F3N5/c1-9(2)26-17(11-6-10(3)15-12(7-11)8-22-24-15)16-13(25-26)4-5-14(23-16)18(19,20)21/h4-9H,1-3H3,(H,22,24)
PDB

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UniChem
US Patent
n/an/a 0.251n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292045
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-methyl-5-(trifluoro...)
Show SMILES Cn1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C15H9ClF3N5/c1-24-14(7-4-8-6-20-22-12(8)9(16)5-7)13-10(23-24)2-3-11(21-13)15(17,18)19/h2-6H,1H3,(H,20,22)
PDB

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UniChem
US Patent
n/an/a 0.316n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292062
PNG
(7-Chloro-5-(5-(difluoromethyl)-2-isopropyl-2H-pyra...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)F
Show InChI InChI=1S/C18H15ClF2N4O/c1-8(2)25-17(16-12(24-25)3-4-13(22-16)18(20)21)10-5-9-7-14(26)23-15(9)11(19)6-10/h3-6,8,18H,7H2,1-2H3,(H,23,26)
PDB

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US Patent
n/an/a 0.398n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292049
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-ethyl-5-(trifluorom...)
Show SMILES CCn1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C16H11ClF3N5/c1-2-25-15(8-5-9-7-21-23-13(9)10(17)6-8)14-11(24-25)3-4-12(22-14)16(18,19)20/h3-7H,2H2,1H3,(H,21,23)
PDB

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US Patent
n/an/a 0.398n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292050
PNG
(5-(2-Isopropyl-5-(trifluoromethyl)-2H-pyrazolo[4,3...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N4O/c1-9(2)26-18(12-6-10(3)16-11(7-12)8-15(27)24-16)17-13(25-26)4-5-14(23-17)19(20,21)22/h4-7,9H,8H2,1-3H3,(H,24,27)
PDB

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US Patent
n/an/a 0.398n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292041
PNG
(2-Cyclobutyl-3-(1H-indazol-5-yl)-5-(trifluoromethy...)
Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3ccc4[nH]ncc4c3)c2n1
Show InChI InChI=1S/C18H14F3N5/c19-18(20,21)15-7-6-14-16(23-15)17(26(25-14)12-2-1-3-12)10-4-5-13-11(8-10)9-22-24-13/h4-9,12H,1-3H2,(H,22,24)
PDB

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US Patent
n/an/a 0.631n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292059
PNG
(2-(Difluoromethyl)-3-(7-methyl-1H-indazol-5-yl)-5-...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(nc2ccc(nc12)C(F)(F)F)C(F)F
Show InChI InChI=1S/C16H10F5N5/c1-7-4-8(5-9-6-22-24-12(7)9)14-13-10(25-26(14)15(17)18)2-3-11(23-13)16(19,20)21/h2-6,15H,1H3,(H,22,24)
PDB

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US Patent
n/an/a 0.631n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292060
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-5-...)
Show SMILES FC(F)n1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C15H7ClF5N5/c16-8-4-6(3-7-5-22-24-11(7)8)13-12-9(25-26(13)14(17)18)1-2-10(23-12)15(19,20)21/h1-5,14H,(H,22,24)
PDB

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US Patent
n/an/a 0.631n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292048
PNG
(2-Ethyl-3-(7-methyl-1H-indazol-5-yl)-5-(trifluorom...)
Show SMILES CCn1nc2ccc(nc2c1-c1cc(C)c2[nH]cnc2c1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N5/c1-3-25-16(10-6-9(2)14-12(7-10)21-8-22-14)15-11(24-25)4-5-13(23-15)17(18,19)20/h4-8H,3H2,1-2H3,(H,21,22)
PDB

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n/an/a 0.794n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292032
PNG
(5-[2-(Difluoromethyl)-5-(trifluoromethyl)pyrazolo[...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C(F)F
Show InChI InChI=1S/C17H11F5N4O/c1-7-4-9(5-8-6-12(27)24-13(7)8)15-14-10(25-26(15)16(18)19)2-3-11(23-14)17(20,21)22/h2-5,16H,6H2,1H3,(H,24,27)
PDB

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n/an/a 1n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292044
PNG
(2-Methyl-3-(7-methyl-1H-indazol-5-yl)-5-(trifluoro...)
Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(C)nc2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C16H12F3N5/c1-8-5-9(6-10-7-20-22-13(8)10)15-14-11(23-24(15)2)3-4-12(21-14)16(17,18)19/h3-7H,1-2H3,(H,20,22)
PDB

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US Patent
n/an/a 1n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292038
PNG
(5-(2-Phenyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]...)
Show SMILES FC(F)(F)c1ccc2nn(c(-c3ccc4[nH]c(=O)[nH]c4c3)c2n1)-c1ccccc1
Show InChI InChI=1S/C20H10F3N5O/c21-20(22,23)16-9-8-14-17(26-16)18(28(27-14)12-4-2-1-3-5-12)11-6-7-13-15(10-11)25-19(29)24-13/h1-10H
PDB

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US Patent
n/an/a 1.58n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292058
PNG
(7-Chloro-5-(2-(difluoromethyl)-5-(trifluoromethyl)...)
Show SMILES FC(F)n1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C16H8ClF5N4O/c17-8-4-7(3-6-5-11(27)24-12(6)8)14-13-9(25-26(14)15(18)19)1-2-10(23-13)16(20,21)22/h1-4,15H,5H2,(H,24,27)
PDB

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US Patent
n/an/a 2.51n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292047
PNG
(7-Chloro-5-(2-ethyl-5-(trifluoromethyl)-2H-pyrazol...)
Show SMILES CCn1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C17H12ClF3N4O/c1-2-25-16(9-5-8-7-13(26)23-14(8)10(18)6-9)15-11(24-25)3-4-12(22-15)17(19,20)21/h3-6H,2,7H2,1H3,(H,23,26)
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US Patent
n/an/a 2.51n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292040
PNG
(3-(1H-Indazol-5-yl)-2-phenyl-5-(trifluoromethyl)-2...)
Show SMILES FC(F)(F)c1ccc2nn(c(-c3ccc4[nH]ncc4c3)c2n1)-c1ccccc1
Show InChI InChI=1S/C20H12F3N5/c21-20(22,23)17-9-8-16-18(25-17)19(28(27-16)14-4-2-1-3-5-14)12-6-7-15-13(10-12)11-24-26-15/h1-11H,(H,24,26)
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n/an/a 3.16n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292046
PNG
(5-(2-Ethyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]p...)
Show SMILES CCn1nc2ccc(nc2c1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4O/c1-3-25-17(11-6-9(2)15-10(7-11)8-14(26)23-15)16-12(24-25)4-5-13(22-16)18(19,20)21/h4-7H,3,8H2,1-2H3,(H,23,26)
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n/an/a 5.01n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292039
PNG
(5-(2-Phenyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]...)
Show SMILES FC(F)(F)c1ccc2nn(c(-c3ccc4NC(=O)Cc4c3)c2n1)-c1ccccc1
Show InChI InChI=1S/C21H13F3N4O/c22-21(23,24)17-9-8-16-19(26-17)20(28(27-16)14-4-2-1-3-5-14)12-6-7-15-13(10-12)11-18(29)25-15/h1-10H,11H2,(H,25,29)
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n/an/a 6.31n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292031
PNG
(7-Methyl-5-(2-methyl-5-(trifluoromethyl)-2H-pyrazo...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1n(C)nc2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H13F3N4O/c1-8-5-10(6-9-7-13(25)22-14(8)9)16-15-11(23-24(16)2)3-4-12(21-15)17(18,19)20/h3-6H,7H2,1-2H3,(H,22,25)
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n/an/a 12.6n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292036
PNG
(5-(2-Cyclopentyl-5-(trifluoromethyl)-2H-pyrazolo[4...)
Show SMILES FC(F)(F)c1ccc2nn(C3CCCC3)c(-c3ccc4[nH]c(=O)[nH]c4c3)c2n1
Show InChI InChI=1S/C19H14F3N5O/c20-19(21,22)15-8-7-13-16(25-15)17(27(26-13)11-3-1-2-4-11)10-5-6-12-14(9-10)24-18(28)23-12/h5-9,11H,1-4H2
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n/an/a 15.8n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292034
PNG
(5-(2-Isopropyl-5-(trifluoromethyl)-2H-pyrazolo[4,3...)
Show SMILES CC(C)n1nc2ccc(nc2c1-c1ccc2[nH]c(=O)[nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C17H12F3N5O/c1-8(2)25-15(9-3-4-10-12(7-9)22-16(26)21-10)14-11(24-25)5-6-13(23-14)17(18,19)20/h3-8H,1-2H3
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n/an/a 25.1n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292064
PNG
(3-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-pyrazolo[...)
Show SMILES CC(C)n1nc2cccnc2c1-c1cc(Cl)c2[nH]ncc2c1
Show InChI InChI=1S/C16H14ClN5/c1-9(2)22-16(15-13(21-22)4-3-5-18-15)10-6-11-8-19-20-14(11)12(17)7-10/h3-9H,1-2H3,(H,19,20)
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n/an/a 63.1n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292033
PNG
(5-(2-Ethyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]p...)
Show SMILES CCn1nc2ccc(nc2c1-c1ccc2[nH]c(=O)[nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C16H10F3N5O/c1-2-24-14(8-3-4-9-11(7-8)21-15(25)20-9)13-10(23-24)5-6-12(22-13)16(17,18)19/h3-7H,2H2,1H3
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n/an/a 100n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292063
PNG
(7-(Difluoromethyl)-2-isopropyl-3-(7-methyl-1H-inda...)
Show SMILES CC(C)n1nc2c(ccnc2c1-c1cc(C)c2[nH]ncc2c1)C(F)F
Show InChI InChI=1S/C18H17F2N5/c1-9(2)25-17(11-6-10(3)14-12(7-11)8-22-23-14)16-15(24-25)13(18(19)20)4-5-21-16/h4-9,18H,1-3H3,(H,22,23)
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n/an/a 126n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292043
PNG
(3-(1H-Indazol-5-yl)-2-(pyridin-2-yl)-5-(trifluorom...)
Show SMILES FC(F)(F)c1ccc2nn(c(-c3ccc4[nH]ncc4c3)c2n1)-c1ccccn1
Show InChI InChI=1S/C19H11F3N6/c20-19(21,22)15-7-6-14-17(25-15)18(28(27-14)16-3-1-2-8-23-16)11-4-5-13-12(9-11)10-24-26-13/h1-10H,(H,24,26)
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n/an/a 126n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292035
PNG
(5-(2-(Cyclobutylmethyl)-5-(trifluoromethyl)-2H-pyr...)
Show SMILES FC(F)(F)c1ccc2nn(CC3CCC3)c(-c3ccc4[nH]c(=O)[nH]c4c3)c2n1
Show InChI InChI=1S/C19H14F3N5O/c20-19(21,22)15-7-6-13-16(25-15)17(27(26-13)9-10-2-1-3-10)11-4-5-12-14(8-11)24-18(28)23-12/h4-8,10H,1-3,9H2
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n/an/a 126n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292030
PNG
(5-(2-Methyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]...)
Show SMILES Cn1nc2ccc(nc2c1-c1ccc2[nH]c(=O)[nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C15H8F3N5O/c1-23-13(7-2-3-8-10(6-7)20-14(24)19-8)12-9(22-23)4-5-11(21-12)15(16,17)18/h2-6H,1H3
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n/an/a 316n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (human))
BDBM292042
PNG
(3-(1H-Indazol-5-yl)-2-(2-methoxyethyl)-5-(trifluor...)
Show SMILES COCCn1nc2ccc(nc2c1-c1ccc2[nH]ncc2c1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N5O/c1-26-7-6-25-16(10-2-3-12-11(8-10)9-21-23-12)15-13(24-25)4-5-14(22-15)17(18,19)20/h2-5,8-9H,6-7H2,1H3,(H,21,23)
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n/an/a 794n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...


US Patent US10100045 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%