BindingDB logo
myBDB logout

Patent code US10100051

Compile Data Set for Download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292143
PNG
(2-(2-((2,3-dihydrobenzo[b][1,4]dioxo-6-yl)oxy)-5-h...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc4OCCOc4c3)nc12
Show InChI InChI=1S/C20H17N3O7/c1-10-17-12(19(26)18(22-10)20(27)21-9-16(24)25)3-5-15(23-17)30-11-2-4-13-14(8-11)29-7-6-28-13/h2-5,8,26H,6-7,9H2,1H3,(H,21,27)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292144
PNG
(2-(2-([1,1′-biphenyl]-4-oxo)-5-hydroxy-8-met...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)-c3ccccc3)nc12
Show InChI InChI=1S/C24H19N3O5/c1-14-21-18(23(30)22(26-14)24(31)25-13-20(28)29)11-12-19(27-21)32-17-9-7-16(8-10-17)15-5-3-2-4-6-15/h2-12,30H,13H2,1H3,(H,25,31)(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 230n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292141
PNG
((2-(2-(4-bromophenoxy)-5-hydroxy-8-methyl-1,7-naph...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(Br)cc3)nc12
Show InChI InChI=1S/C18H14BrN3O5/c1-9-15-12(17(25)16(21-9)18(26)20-8-14(23)24)6-7-13(22-15)27-11-4-2-10(19)3-5-11/h2-7,25H,8H2,1H3,(H,20,26)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 330n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292142
PNG
(2-(2-(3-(tert-butyl)phenoxy)-5-hydroxy-8-methyl-1,...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3cccc(c3)C(C)(C)C)nc12
Show InChI InChI=1S/C22H23N3O5/c1-12-18-15(20(28)19(24-12)21(29)23-11-17(26)27)8-9-16(25-18)30-14-7-5-6-13(10-14)22(2,3)4/h5-10,28H,11H2,1-4H3,(H,23,29)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 510n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292145
PNG
(2-(5-hydroxy-2-(4-methoxyphenoxy)-8-methyl-1,7-nap...)
Show SMILES COc1ccc(Oc2ccc3c(O)c(nc(C)c3n2)C(=O)NCC(O)=O)cc1
Show InChI InChI=1S/C19H17N3O6/c1-10-16-13(18(25)17(21-10)19(26)20-9-15(23)24)7-8-14(22-16)28-12-5-3-11(27-2)4-6-12/h3-8,25H,9H2,1-2H3,(H,20,26)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292135
PNG
(2-(2-(4-cyanophenoxy)-5-hydroxy-8-methyl-1,7-napht...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)C#N)nc12
Show InChI InChI=1S/C19H14N4O5/c1-10-16-13(18(26)17(22-10)19(27)21-9-15(24)25)6-7-14(23-16)28-12-4-2-11(8-20)3-5-12/h2-7,26H,9H2,1H3,(H,21,27)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292138
PNG
(2-(2-(4-chlorophenoxy)-5-hydroxy-8-methyl-1,7-naph...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C18H14ClN3O5/c1-9-15-12(17(25)16(21-9)18(26)20-8-14(23)24)6-7-13(22-15)27-11-4-2-10(19)3-5-11/h2-7,25H,8H2,1H3,(H,20,26)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.00E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292140
PNG
(2-(2-(3-cyanophenoxy)-5-hydroxy-8-methyl-1,7-napht...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3cccc(c3)C#N)nc12
Show InChI InChI=1S/C19H14N4O5/c1-10-16-13(18(26)17(22-10)19(27)21-9-15(24)25)5-6-14(23-16)28-12-4-2-3-11(7-12)8-20/h2-7,26H,9H2,1H3,(H,21,27)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292137
PNG
(2-(5-hydroxy-2-phenoxy-1,7-naphthyridine-6-formami...)
Show SMILES OC(=O)CNC(=O)c1ncc2nc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C17H13N3O5/c21-14(22)9-19-17(24)15-16(23)11-6-7-13(20-12(11)8-18-15)25-10-4-2-1-3-5-10/h1-8,23H,9H2,(H,19,24)(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.90E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292132
PNG
(2-(5-hydroxy-8-methyl-2-phenoxy-1,7-naphthyridine-...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccccc3)nc12
Show InChI InChI=1S/C18H15N3O5/c1-10-15-12(17(24)16(20-10)18(25)19-9-14(22)23)7-8-13(21-15)26-11-5-3-2-4-6-11/h2-8,24H,9H2,1H3,(H,19,25)(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292139
PNG
((2-5-hydroxy-8-methyl-2-(4-(trifluoromethyl)phenox...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)C(F)(F)F)nc12
Show InChI InChI=1S/C19H14F3N3O5/c1-9-15-12(17(28)16(24-9)18(29)23-8-14(26)27)6-7-13(25-15)30-11-4-2-10(3-5-11)19(20,21)22/h2-7,28H,8H2,1H3,(H,23,29)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292134
PNG
(2-(2-(3-chlorophenoxy)-5-hydroxy-8-methyl-1,7-naph...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3cccc(Cl)c3)nc12
Show InChI InChI=1S/C18H14ClN3O5/c1-9-15-12(17(25)16(21-9)18(26)20-8-14(23)24)5-6-13(22-15)27-11-4-2-3-10(19)7-11/h2-7,25H,8H2,1H3,(H,20,26)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.80E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292136
PNG
(2-(2-(4-(tert-butyl)phenoxy)-5-hydroxy-8-methyl-1,...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)C(C)(C)C)nc12
Show InChI InChI=1S/C22H23N3O5/c1-12-18-15(20(28)19(24-12)21(29)23-11-17(26)27)9-10-16(25-18)30-14-7-5-13(6-8-14)22(2,3)4/h5-10,28H,11H2,1-4H3,(H,23,29)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.90E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292133
PNG
((2-(2-(4-fluorophenoxy)-5-hydroxy-8-methyl-1,7-nap...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(F)cc3)nc12
Show InChI InChI=1S/C18H14FN3O5/c1-9-15-12(17(25)16(21-9)18(26)20-8-14(23)24)6-7-13(22-15)27-11-4-2-10(19)3-5-11/h2-7,25H,8H2,1H3,(H,20,26)(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.30E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%