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Patent code US10105367

Compile Data Set for Download or QSAR

Found 304 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289551
PNG
(8-(2-Oxa-7-azaspiro[3.5]nonan-7-ylmethyl)-6-(4-met...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCC5(COC5)CC4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H25N5O3S/c1-30-17-4-2-16(3-5-17)11-27-21-19(20-24-15-25-28(20)22(27)29)10-18(32-21)12-26-8-6-23(7-9-26)13-31-14-23/h2-5,10,15H,6-9,11-14H2,1H3
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US Patent
n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289553
PNG
(6-(4-Methoxybenzyl)-8-(1-methyl-3-(trifluoromethyl...)
Show SMILES COc1ccc(Cn2c3sc(cc3c3ncnn3c2=O)-c2cc(nn2C)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N6O2S/c1-27-14(8-16(26-27)20(21,22)23)15-7-13-17-24-10-25-29(17)19(30)28(18(13)32-15)9-11-3-5-12(31-2)6-4-11/h3-8,10H,9H2,1-2H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289579
PNG
(8-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-6-(4...)
Show SMILES COc1ccc(Cn2c3sc(CN4CC5CCC(C4)O5)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H25N5O3S/c1-14-19(12-26-10-17-7-8-18(11-26)31-17)32-22-20(14)21-24-13-25-28(21)23(29)27(22)9-15-3-5-16(30-2)6-4-15/h3-6,13,17-18H,7-12H2,1-2H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289586
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((3,3,4-trimethylpi...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(C)C(C)(C)C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H30N6O2S/c1-16-19(13-28-11-10-27(4)24(2,3)14-28)33-22-20(16)21-25-15-26-30(21)23(31)29(22)12-17-6-8-18(32-5)9-7-17/h6-9,15H,10-14H2,1-5H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289617
PNG
(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)
Show SMILES Clc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H24ClN5O2S/c24-17-3-1-15(2-4-17)12-28-22-20(21-25-14-26-29(21)23(28)30)18-5-8-27(13-19(18)32-22)11-16-6-9-31-10-7-16/h1-4,14,16H,5-13H2
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289625
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydrofuran-3-yl)methy...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H25N5O3S/c1-30-17-4-2-15(3-5-17)11-27-22-20(21-24-14-25-28(21)23(27)29)18-6-8-26(12-19(18)32-22)10-16-7-9-31-13-16/h2-5,14,16H,6-13H2,1H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289638
PNG
(6-(4-Methoxybenzyl)-9-(5-oxotetrahydrofuran-2-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCC(=O)O5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-15-4-2-14(3-5-15)10-27-22-20(21-24-13-25-28(21)23(27)30)17-8-9-26(12-18(17)33-22)11-16-6-7-19(29)32-16/h2-5,13,16H,6-12H2,1H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289645
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydrofuran-3-...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CC4CCOC4)CCc3c2c2ncnn2c1=O
Show InChI InChI=1S/C22H21ClFN5O2S/c23-15-2-1-14(17(24)7-15)9-28-21-19(20-25-12-26-29(20)22(28)30)16-3-5-27(10-18(16)32-21)8-13-4-6-31-11-13/h1-2,7,12-13H,3-6,8-11H2
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289658
PNG
(6-(4-Methoxybenzyl)-9-(pyridin-2-ylmethyl)-6,8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccccn5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H24N6O2S/c1-33-19-9-7-17(8-10-19)13-30-24-22(23-27-16-28-31(23)25(30)32)20-6-4-12-29(15-21(20)34-24)14-18-5-2-3-11-26-18/h2-3,5,7-11,16H,4,6,12-15H2,1H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM292961
PNG
(US10105367, Example 247)
Show SMILES COc1ccc(Cn2c3ncc(CN4C[C@H](C)OC[C@@H]4C)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H26N6O3/c1-15-13-32-16(2)10-27(15)11-18-8-20-21(24-9-18)28(23(30)29-22(20)25-14-26-29)12-17-4-6-19(31-3)7-5-17/h4-9,14-16H,10-13H2,1-3H3/t15-,16-/m0/s1
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289543
PNG
(6-(4-Methoxybenzyl)-8-(morpholinomethyl)thieno[3,2...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCOCC4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C20H21N5O3S/c1-27-15-4-2-14(3-5-15)11-24-19-17(18-21-13-22-25(18)20(24)26)10-16(29-19)12-23-6-8-28-9-7-23/h2-5,10,13H,6-9,11-12H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289545
PNG
(8-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-6-(4-me...)
Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O3S/c1-14-9-25(10-15(2)30-14)12-18-8-19-20-23-13-24-27(20)22(28)26(21(19)31-18)11-16-4-6-17(29-3)7-5-16/h4-8,13-15H,9-12H2,1-3H3/t14-,15+
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289632
PNG
(6-(4-Methoxybenzyl)-9-(pyridin-2-ylmethyl)-8,9,10,...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccccn5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H22N6O2S/c1-32-18-7-5-16(6-8-18)12-29-23-21(22-26-15-27-30(22)24(29)31)19-9-11-28(14-20(19)33-23)13-17-4-2-3-10-25-17/h2-8,10,15H,9,11-14H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289659
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H29N5O3S/c1-32-19-6-4-17(5-7-19)14-29-24-22(23-26-16-27-30(23)25(29)31)20-3-2-10-28(15-21(20)34-24)13-18-8-11-33-12-9-18/h4-7,16,18H,2-3,8-15H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289661
PNG
(6-(4-Methoxybenzyl)-8-((tetrahydro-2H-pyran-3-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4N(CC5CCCOC5)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-8-6-16(7-9-18)13-28-23-20(21-25-15-26-29(21)24(28)30)19-5-2-10-27(22(19)33-23)12-17-4-3-11-32-14-17/h6-9,15,17H,2-5,10-14H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289675
PNG
(6-(4-Chloro-2-fluorobenzyl)-9-(cyclopropanecarbony...)
Show SMILES Fc1cc(Cl)ccc1Cn1c2sc3CN(CCc3c2c2ncnn2c1=O)C(=O)C1CC1
Show InChI InChI=1S/C21H17ClFN5O2S/c22-13-4-3-12(15(23)7-13)8-27-20-17(18-24-10-25-28(18)21(27)30)14-5-6-26(9-16(14)31-20)19(29)11-1-2-11/h3-4,7,10-11H,1-2,5-6,8-9H2
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM292982
PNG
(US10105367, Example 268)
Show SMILES COc1ccc(Cn2c3ncc(cc3c3ncnn3c2=O)C(O)CN2C[C@H](C)O[C@H](C)C2)cc1
Show InChI InChI=1S/C24H28N6O4/c1-15-10-28(11-16(2)34-15)13-21(31)18-8-20-22(25-9-18)29(24(32)30-23(20)26-14-27-30)12-17-4-6-19(33-3)7-5-17/h4-9,14-16,21,31H,10-13H2,1-3H3/t15-,16+,21?
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM292986
PNG
(6-(4-Methoxybenzyl)-9-(2,2,2-trifluoro-1-morpholin...)
Show SMILES COc1ccc(Cn2c3ncc(cc3c3ncnn3c2=O)C(N2CCOCC2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H21F3N6O3/c1-33-16-4-2-14(3-5-16)12-30-19-17(20-27-13-28-31(20)21(30)32)10-15(11-26-19)18(22(23,24)25)29-6-8-34-9-7-29/h2-5,10-11,13,18H,6-9,12H2,1H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289547
PNG
(6-(4-Methoxybenzyl)-8-((4-(methylsulfonyl)piperazi...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)S(C)(=O)=O)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H24N6O4S2/c1-31-16-5-3-15(4-6-16)12-26-20-18(19-22-14-23-27(19)21(26)28)11-17(32-20)13-24-7-9-25(10-8-24)33(2,29)30/h3-6,11,14H,7-10,12-13H2,1-2H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289557
PNG
(8-((Dimethylamino)methyl)-6-(4-methoxybenzyl)-9-me...)
Show SMILES COc1ccc(Cn2c3sc(CN(C)C)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C19H21N5O2S/c1-12-15(10-22(2)3)27-18-16(12)17-20-11-21-24(17)19(25)23(18)9-13-5-7-14(26-4)8-6-13/h5-8,11H,9-10H2,1-4H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289559
PNG
(8-((4-Hydroxypiperidin-1-yl)methyl)-6-(4-methoxybe...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCC(O)CC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O3S/c1-14-18(12-25-9-7-16(28)8-10-25)31-21-19(14)20-23-13-24-27(20)22(29)26(21)11-15-3-5-17(30-2)6-4-15/h3-6,13,16,28H,7-12H2,1-2H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289563
PNG
(8-((4-Acetylpiperazin-1-yl)methyl)-6-(4-methoxyben...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)C(C)=O)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H26N6O3S/c1-15-19(13-26-8-10-27(11-9-26)16(2)30)33-22-20(15)21-24-14-25-29(21)23(31)28(22)12-17-4-6-18(32-3)7-5-17/h4-7,14H,8-13H2,1-3H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289570
PNG
((S)-6-(4-Methoxybenzyl)-8-((2-(methoxymethyl)pyrro...)
Show SMILES COC[C@@H]1CCCN1Cc1sc2n(Cc3ccc(OC)cc3)c(=O)n3ncnc3c2c1C
Show InChI InChI=1S/C23H27N5O3S/c1-15-19(12-26-10-4-5-17(26)13-30-2)32-22-20(15)21-24-14-25-28(21)23(29)27(22)11-16-6-8-18(31-3)9-7-16/h6-9,14,17H,4-5,10-13H2,1-3H3/t17-/m0/s1
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289574
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((4-methylpiperazin...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(C)CC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H26N6O2S/c1-15-18(13-26-10-8-25(2)9-11-26)31-21-19(15)20-23-14-24-28(20)22(29)27(21)12-16-4-6-17(30-3)7-5-16/h4-7,14H,8-13H2,1-3H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289582
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-((2-methylmorpholin...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCOC(C)C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O3S/c1-14-10-25(8-9-30-14)12-18-15(2)19-20-23-13-24-27(20)22(28)26(21(19)31-18)11-16-4-6-17(29-3)7-5-16/h4-7,13-14H,8-12H2,1-3H3
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n/an/a<100n/an/an/an/an/a25



DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289585
PNG
(8-((3,4-Dimethylpiperazin-1-yl)methyl)-6-(4-methox...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN(C)C(C)C4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H28N6O2S/c1-15-11-27(10-9-26(15)3)13-19-16(2)20-21-24-14-25-29(21)23(30)28(22(20)32-19)12-17-5-7-18(31-4)8-6-17/h5-8,14-15H,9-13H2,1-4H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289630
PNG
(6-(4-Methoxybenzyl)-9-(3-(methylsulfonyl)propyl)-8...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCCS(C)(=O)=O)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H25N5O4S2/c1-31-16-6-4-15(5-7-16)12-26-21-19(20-23-14-24-27(20)22(26)28)17-8-10-25(13-18(17)32-21)9-3-11-33(2,29)30/h4-7,14H,3,8-13H2,1-2H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289639
PNG
(9-(4-Fluorobenzyl)-6-(4-methoxybenzyl)-8,9,10,11-t...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccc(F)cc5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H22FN5O2S/c1-33-19-8-4-17(5-9-19)13-30-24-22(23-27-15-28-31(23)25(30)32)20-10-11-29(14-21(20)34-24)12-16-2-6-18(26)7-3-16/h2-9,15H,10-14H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289673
PNG
(6-(4-Methoxybenzyl)-9-(methylsulfonyl)-8,9,10,11-t...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)S(C)(=O)=O)cc1
Show InChI InChI=1S/C19H19N5O4S2/c1-28-13-5-3-12(4-6-13)9-23-18-16(17-20-11-21-24(17)19(23)25)14-7-8-22(30(2,26)27)10-15(14)29-18/h3-6,11H,7-10H2,1-2H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289678
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-(tetrahydrofuran-3-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)c(F)c1
Show InChI InChI=1S/C23H22FN5O4S/c1-32-15-3-2-13(17(24)8-15)9-28-22-19(20-25-12-26-29(20)23(28)31)16-4-6-27(10-18(16)34-22)21(30)14-5-7-33-11-14/h2-3,8,12,14H,4-7,9-11H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289686
PNG
(6-(4-Methoxybenzyl)-8-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4N(CCCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-6-4-14(5-7-16)11-27-22-18(19-24-13-25-28(19)23(27)30)17-3-2-9-26(21(17)33-22)20(29)15-8-10-32-12-15/h4-7,13,15H,2-3,8-12H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM292938
PNG
(US10105367, Example 224)
Show SMILES CCC1CN(Cc2cnc3n(Cc4ccc(OC)cc4)c(=O)n4ncnc4c3c2)CCO1
Show InChI InChI=1S/C23H26N6O3/c1-3-18-14-27(8-9-32-18)12-17-10-20-21(24-11-17)28(23(30)29-22(20)25-15-26-29)13-16-4-6-19(31-2)7-5-16/h4-7,10-11,15,18H,3,8-9,12-14H2,1-2H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM292960
PNG
(US10105367, Example 246)
Show SMILES COc1ccc(Cn2c3ncc(CN4CCN5C(COC5=O)C4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H23N7O4/c1-33-18-4-2-15(3-5-18)11-29-20-19(21-25-14-26-30(21)22(29)31)8-16(9-24-20)10-27-6-7-28-17(12-27)13-34-23(28)32/h2-5,8-9,14,17H,6-7,10-13H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM292991
PNG
(US10105367, Example 277)
Show SMILES COc1ccc(Cn2c3ncc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H25FN6O3/c1-14-9-28(10-15(2)33-14)11-16-6-19-21(25-8-16)29(23(31)30-22(19)26-13-27-30)12-17-4-5-18(32-3)7-20(17)24/h4-8,13-15H,9-12H2,1-3H3/t14-,15+
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289578
PNG
(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Show SMILES CCN1CCN(Cc2sc3n(Cc4ccc(OC)cc4)c(=O)n4ncnc4c3c2C)CC1=O
Show InChI InChI=1S/C23H26N6O3S/c1-4-27-10-9-26(13-19(27)30)12-18-15(2)20-21-24-14-25-29(21)23(31)28(22(20)33-18)11-16-5-7-17(32-3)8-6-16/h5-8,14H,4,9-13H2,1-3H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289627
PNG
(6-(4-Methoxybenzyl)-9-neopentyl-8,9,10,11-tetrahyd...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC(C)(C)C)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H27N5O2S/c1-23(2,3)13-26-10-9-17-18(12-26)31-21-19(17)20-24-14-25-28(20)22(29)27(21)11-15-5-7-16(30-4)8-6-15/h5-8,14H,9-13H2,1-4H3
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Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289628
PNG
(6-(4-Methoxybenzyl)-9-(pyrimidin-2-ylmethyl)-8,9,1...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ncccn5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H21N7O2S/c1-32-16-5-3-15(4-6-16)11-29-22-20(21-26-14-27-30(21)23(29)31)17-7-10-28(12-18(17)33-22)13-19-24-8-2-9-25-19/h2-6,8-9,14H,7,10-13H2,1H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289634
PNG
(6-(4-Methoxybenzyl)-9-((1-methyl-1H-imidazol-2-yl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5nccn5C)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H23N7O2S/c1-27-10-8-24-19(27)13-28-9-7-17-18(12-28)33-22-20(17)21-25-14-26-30(21)23(31)29(22)11-15-3-5-16(32-2)6-4-15/h3-6,8,10,14H,7,9,11-13H2,1-2H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289640
PNG
(9-(2-Fluorobenzyl)-6-(4-methoxybenzyl)-8,9,10,11-t...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5ccccc5F)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C25H22FN5O2S/c1-33-18-8-6-16(7-9-18)12-30-24-22(23-27-15-28-31(23)25(30)32)19-10-11-29(14-21(19)34-24)13-17-4-2-3-5-20(17)26/h2-9,15H,10-14H2,1H3
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Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289646
PNG
(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-3-yl)m...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCCOC5)CCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H27N5O3S/c1-31-18-6-4-16(5-7-18)12-28-23-21(22-25-15-26-29(22)24(28)30)19-8-9-27(13-20(19)33-23)11-17-3-2-10-32-14-17/h4-7,15,17H,2-3,8-14H2,1H3
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Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289647
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CC(F)(F)c4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25F2N5O3S/c1-33-17-4-2-15(3-5-17)11-30-22-19(21-27-14-28-31(21)23(30)32)20-18(35-22)12-29(13-24(20,25)26)10-16-6-8-34-9-7-16/h2-5,14,16H,6-13H2,1H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289650
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((1-methyl-1H-imida...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5nccn5C)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H22FN7O2S/c1-28-8-6-25-19(28)12-29-7-5-16-18(11-29)34-22-20(16)21-26-13-27-31(21)23(32)30(22)10-14-3-4-15(33-2)9-17(14)24/h3-4,6,8-9,13H,5,7,10-12H2,1-2H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289652
PNG
(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydrofuran-3...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOC5)CCc4c3c3ncnn3c2=O)c(F)c1
Show InChI InChI=1S/C23H24FN5O3S/c1-31-16-3-2-15(18(24)8-16)10-28-22-20(21-25-13-26-29(21)23(28)30)17-4-6-27(11-19(17)33-22)9-14-5-7-32-12-14/h2-3,8,13-14H,4-7,9-12H2,1H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289656
PNG
(6-(4-Methoxybenzyl)-9-((1-methyl-1H-imidazol-2-yl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(Cc5nccn5C)CCCc4c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C24H25N7O2S/c1-28-11-9-25-20(28)14-29-10-3-4-18-19(13-29)34-23-21(18)22-26-15-27-31(22)24(32)30(23)12-16-5-7-17(33-2)8-6-16/h5-9,11,15H,3-4,10,12-14H2,1-2H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289672
PNG
(6-(4-Methoxybenzyl)-9-(tetrahydrofuran-3-carbonyl)...)
Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H23N5O4S/c1-31-16-4-2-14(3-5-16)10-27-22-19(20-24-13-25-28(20)23(27)30)17-6-8-26(11-18(17)33-22)21(29)15-7-9-32-12-15/h2-5,13,15H,6-12H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289677
PNG
(11,11-Difluoro-6-(4-methoxybenzyl)-9-(tetrahydrofu...)
Show SMILES COc1ccc(Cn2c3sc4CN(CC(F)(F)c4c3c3ncnn3c2=O)C(=O)C2CCOC2)cc1
Show InChI InChI=1S/C23H21F2N5O4S/c1-33-15-4-2-13(3-5-15)8-29-21-17(19-26-12-27-30(19)22(29)32)18-16(35-21)9-28(11-23(18,24)25)20(31)14-6-7-34-10-14/h2-5,12,14H,6-11H2,1H3
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DART NEUROSCIENCE (CAYMAN) LTD.

US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM292934
PNG
(US10105367, Example 220)
Show SMILES COc1ccc(Cn2c3ncc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C23H26N6O3/c1-15-10-27(11-16(2)32-15)12-18-8-20-21(24-9-18)28(23(30)29-22(20)25-14-26-29)13-17-4-6-19(31-3)7-5-17/h4-9,14-16H,10-13H2,1-3H3/t15-,16+
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289546
PNG
(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Show SMILES CCN1CCN(Cc2cc3c4ncnn4c(=O)n(Cc4ccc(OC)cc4)c3s2)CC1=O
Show InChI InChI=1S/C22H24N6O3S/c1-3-26-9-8-25(13-19(26)29)12-17-10-18-20-23-14-24-28(20)22(30)27(21(18)32-17)11-15-4-6-16(31-2)7-5-15/h4-7,10,14H,3,8-9,11-13H2,1-2H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289552
PNG
(7-((6-(4-Methoxybenzyl)-5-oxo-5,6-dihydrothieno[3,...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCN5C(COC5=O)C4)cc3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C22H22N6O4S/c1-31-16-4-2-14(3-5-16)9-27-20-18(19-23-13-24-28(19)21(27)29)8-17(33-20)11-25-6-7-26-15(10-25)12-32-22(26)30/h2-5,8,13,15H,6-7,9-12H2,1H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (human))
BDBM289556
PNG
(6-(4-Methoxybenzyl)-9-methyl-8-(morpholinomethyl)t...)
Show SMILES COc1ccc(Cn2c3sc(CN4CCOCC4)c(C)c3c3ncnn3c2=O)cc1
Show InChI InChI=1S/C21H23N5O3S/c1-14-17(12-24-7-9-29-10-8-24)30-20-18(14)19-22-13-23-26(19)21(27)25(20)11-15-3-5-16(28-2)6-4-15/h3-6,13H,7-12H2,1-2H3
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US Patent


Assay Description
PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...


US Patent US10105367 (2018)

More data for this
Ligand-Target Pair
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