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Patent code US10106504

Compile Data Set for Download or QSAR
Found 83 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293270
PNG
(US10106504, Example 7)
Show SMILES CCOc1ccc(cc1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1S/C31H36FNO5/c1-8-36-21-13-11-20(12-14-21)25-18(3)33-19(4)26(29(30(34)35)38-31(5,6)7)27(25)23-16-24(32)28-22(17(23)2)10-9-15-37-28/h11-14,16,29H,8-10,15H2,1-7H3,(H,34,35)/t29-/m0/s1
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n/an/an/an/a 545n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293319
PNG
(US10106504, Example 56)
Show SMILES Cc1cc(F)ccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C39H43FN2O4/c1-23-18-32(40)13-11-30(23)21-42-16-15-26-19-28(9-10-31(26)22-42)34-24(2)41-25(3)35(37(38(43)44)46-39(4,5)6)36(34)29-12-14-33-27(20-29)8-7-17-45-33/h9-14,18-20,37H,7-8,15-17,21-22H2,1-6H3,(H,43,44)/t37-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293328
PNG
(US10106504, Example 65)
Show SMILES Cc1cc(nc(C)n1)N1CCc2cc(ccc2C1)-c1c(N)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C36H41N5O4/c1-20-16-29(40-22(3)38-20)41-14-13-23-17-26(9-10-27(23)19-41)32-31(25-11-12-28-24(18-25)8-7-15-44-28)30(21(2)39-34(32)37)33(35(42)43)45-36(4,5)6/h9-12,16-18,33H,7-8,13-15,19H2,1-6H3,(H2,37,39)(H,42,43)/t33-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293329
PNG
(US10106504, Example 66)
Show SMILES Cc1nc(CCCC2CCOCC2)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C43H50FNO6/c1-28-38(41(42(46)47)51-43(2,3)4)40(33-14-19-37-32(27-33)8-6-23-50-37)39(36(45-28)9-5-7-29-20-24-48-25-21-29)31-12-17-35(18-13-31)49-26-22-30-10-15-34(44)16-11-30/h10-19,27,29,41H,5-9,20-26H2,1-4H3,(H,46,47)/t41-/m0/s1
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n/an/an/an/a 6n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293284
PNG
(US10106504, Example 21)
Show SMILES Cc1nc(C)c(-c2ccc3CNCCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C31H36N2O4/c1-18-26(22-8-9-24-17-32-13-12-20(24)15-22)28(23-10-11-25-21(16-23)7-6-14-36-25)27(19(2)33-18)29(30(34)35)37-31(3,4)5/h8-11,15-16,29,32H,6-7,12-14,17H2,1-5H3,(H,34,35)/t29-/m0/s1
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n/an/an/an/a>1.00E+3n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293285
PNG
(US10106504, Example 22)
Show SMILES CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C32H38N2O4/c1-19-27(23-9-10-25-18-34(6)14-13-21(25)16-23)29(24-11-12-26-22(17-24)8-7-15-37-26)28(20(2)33-19)30(31(35)36)38-32(3,4)5/h9-12,16-17,30H,7-8,13-15,18H2,1-6H3,(H,35,36)/t30-/m0/s1
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n/an/an/an/a 550n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293290
PNG
(US10106504, Example 27)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4Cl)CCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H41ClN2O4/c1-23-33(27-12-13-29-21-41(17-16-25(29)19-27)22-30-9-6-7-11-31(30)39)35(28-14-15-32-26(20-28)10-8-18-44-32)34(24(2)40-23)36(37(42)43)45-38(3,4)5/h6-7,9,11-15,19-20,36H,8,10,16-18,21-22H2,1-5H3,(H,42,43)/t36-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293290
PNG
(US10106504, Example 27)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4Cl)CCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H41ClN2O4/c1-23-33(27-12-13-29-21-41(17-16-25(29)19-27)22-30-9-6-7-11-31(30)39)35(28-14-15-32-26(20-28)10-8-18-44-32)34(24(2)40-23)36(37(42)43)45-38(3,4)5/h6-7,9,11-15,19-20,36H,8,10,16-18,21-22H2,1-5H3,(H,42,43)/t36-/m0/s1
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n/an/an/an/a 5n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293293
PNG
(US10106504, Example 30)
Show SMILES Cc1nc(C)c(-c2ccc3CN(CCc4ccccc4F)CCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C39H43FN2O4/c1-24-34(29-12-13-31-23-42(19-17-27(31)21-29)18-16-26-9-6-7-11-32(26)40)36(30-14-15-33-28(22-30)10-8-20-45-33)35(25(2)41-24)37(38(43)44)46-39(3,4)5/h6-7,9,11-15,21-22,37H,8,10,16-20,23H2,1-5H3,(H,43,44)/t37-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293294
PNG
(US10106504, Example 31)
Show SMILES Cc1nc(C)c(-c2ccc3CN(CCCc4ccc(F)cc4)CCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C40H45FN2O4/c1-25-35(30-12-13-32-24-43(20-18-28(32)22-30)19-6-8-27-10-15-33(41)16-11-27)37(31-14-17-34-29(23-31)9-7-21-46-34)36(26(2)42-25)38(39(44)45)47-40(3,4)5/h10-17,22-23,38H,6-9,18-21,24H2,1-5H3,(H,44,45)/t38-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293299
PNG
(US10106504, Example 36)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCC(F)(F)c3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H36F3NO5/c1-21-30(24-8-13-27(14-9-24)43-18-16-23-6-11-26(37)12-7-23)32(25-10-15-29-28(20-25)36(38,39)17-19-44-29)31(22(2)40-21)33(34(41)42)45-35(3,4)5/h6-15,20,33H,16-19H2,1-5H3,(H,41,42)/t33-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293300
PNG
(US10106504, Example 37)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4F)CCc3c2)c(-c2ccc3OCCC(F)(F)c3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H39F3N2O4/c1-22-32(25-10-11-27-20-43(16-14-24(27)18-25)21-28-8-6-7-9-30(28)39)34(26-12-13-31-29(19-26)38(40,41)15-17-46-31)33(23(2)42-22)35(36(44)45)47-37(3,4)5/h6-13,18-19,35H,14-17,20-21H2,1-5H3,(H,44,45)/t35-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293306
PNG
(US10106504, Example 43)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCc4ccnc2c34)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H37FN2O5/c1-22-31(25-8-12-28(13-9-25)44-20-17-24-6-10-27(39)11-7-24)34(32(23(2)41-22)36(37(42)43)46-38(3,4)5)29-14-15-30-33-26(18-21-45-30)16-19-40-35(29)33/h6-16,19,36H,17-18,20-21H2,1-5H3,(H,42,43)/t36-/m0/s1
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n/an/an/an/a 550n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293269
PNG
(US10106504, Example 6)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2cc(F)c3OCCCc3c2C)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H39F2NO5/c1-21-28-8-7-18-44-34(28)30(39)20-29(21)33-31(22(2)40-23(3)32(33)35(36(41)42)45-37(4,5)6)25-11-15-27(16-12-25)43-19-17-24-9-13-26(38)14-10-24/h9-16,20,35H,7-8,17-19H2,1-6H3,(H,41,42)/t35-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293312
PNG
(US10106504, Example 49)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1
Show InChI InChI=1S/C39H42F2N2O4/c1-22-9-7-11-31(40)30(22)21-43-15-14-25-17-26(12-13-28(25)20-43)33-23(2)42-24(3)34(37(38(44)45)47-39(4,5)6)35(33)29-18-27-10-8-16-46-36(27)32(41)19-29/h7,9,11-13,17-19,37H,8,10,14-16,20-21H2,1-6H3,(H,44,45)/t37-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293325
PNG
(US10106504, Example 62)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(N)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C38H42FN3O4/c1-22-8-6-10-30(39)29(22)21-42-16-15-24-18-27(11-12-28(24)20-42)34-33(26-13-14-31-25(19-26)9-7-17-45-31)32(23(2)41-36(34)40)35(37(43)44)46-38(3,4)5/h6,8,10-14,18-19,35H,7,9,15-17,20-21H2,1-5H3,(H2,40,41)(H,43,44)/t35-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293326
PNG
(US10106504, Example 63)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(N)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C38H42ClN3O4/c1-22-8-6-10-30(39)29(22)21-42-16-15-24-18-27(11-12-28(24)20-42)34-33(26-13-14-31-25(19-26)9-7-17-45-31)32(23(2)41-36(34)40)35(37(43)44)46-38(3,4)5/h6,8,10-14,18-19,35H,7,9,15-17,20-21H2,1-5H3,(H2,40,41)(H,43,44)/t35-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293292
PNG
(US10106504, Example 29)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C39H43ClN2O4/c1-23-9-7-11-32(40)31(23)22-42-17-16-26-19-28(12-13-30(26)21-42)34-24(2)41-25(3)35(37(38(43)44)46-39(4,5)6)36(34)29-14-15-33-27(20-29)10-8-18-45-33/h7,9,11-15,19-20,37H,8,10,16-18,21-22H2,1-6H3,(H,43,44)/t37-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293264
PNG
(US10106504, Example 1)
Show SMILES Cc1nc(C)c(-c2cc(F)c3OCCCc3c2C)c(-c2cc(F)c3OCCCc3c2C)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C33H37F2NO5/c1-16-20-10-8-12-39-29(20)24(34)14-22(16)26-18(3)36-19(4)27(31(32(37)38)41-33(5,6)7)28(26)23-15-25(35)30-21(17(23)2)11-9-13-40-30/h14-15,31H,8-13H2,1-7H3,(H,37,38)/t31-/m0/s1
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n/an/an/an/a>1.00E+3n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293266
PNG
(US10106504, Example 3)
Show SMILES COc1ccc(COc2ccc(cc2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2-c2ccc(C)cc2)cc1
Show InChI InChI=1S/C34H37NO5/c1-21-8-12-26(13-9-21)31-29(22(2)35-23(3)30(31)32(33(36)37)40-34(4,5)6)25-14-18-28(19-15-25)39-20-24-10-16-27(38-7)17-11-24/h8-19,32H,20H2,1-7H3,(H,36,37)/t32-/m0/s1
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n/an/an/an/a 196n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293267
PNG
(US10106504, Example 4)
Show SMILES COc1ccc(COc2ccc(cc2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2-c2ccc(OCc3ccc(OC)cc3)cc2)cc1
Show InChI InChI=1S/C41H43NO7/c1-26-36(30-12-20-34(21-13-30)47-24-28-8-16-32(45-6)17-9-28)38(37(27(2)42-26)39(40(43)44)49-41(3,4)5)31-14-22-35(23-15-31)48-25-29-10-18-33(46-7)19-11-29/h8-23,39H,24-25H2,1-7H3,(H,43,44)/t39-/m0/s1
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n/an/an/an/a 550n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293271
PNG
(US10106504, Example 8)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C41H41F2NO5/c1-26-36(30-10-18-34(19-11-30)47-24-22-28-6-14-32(42)15-7-28)38(37(27(2)44-26)39(40(45)46)49-41(3,4)5)31-12-20-35(21-13-31)48-25-23-29-8-16-33(43)17-9-29/h6-21,39H,22-25H2,1-5H3,(H,45,46)/t39-/m0/s1
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n/an/an/an/a 550n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293273
PNG
(US10106504, Example 10)
Show SMILES CN(C)Cc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc(OCCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C38H43FN2O5/c1-24-33(36(37(42)43)46-38(2,3)4)35(28-13-18-32-27(22-28)8-7-20-45-32)34(31(40-24)23-41(5)6)26-11-16-30(17-12-26)44-21-19-25-9-14-29(39)15-10-25/h9-18,22,36H,7-8,19-21,23H2,1-6H3,(H,42,43)/t36-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293281
PNG
(US10106504, Example 18)
Show SMILES CCOCCOCCOCc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc(OCCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C42H50FNO8/c1-6-47-22-23-48-24-25-49-27-35-38(30-11-16-34(17-12-30)50-21-19-29-9-14-33(43)15-10-29)39(32-13-18-36-31(26-32)8-7-20-51-36)37(28(2)44-35)40(41(45)46)52-42(3,4)5/h9-18,26,40H,6-8,19-25,27H2,1-5H3,(H,45,46)/t40-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293283
PNG
(US10106504, Example 20)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccc(F)cc4)CCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H41FN2O4/c1-23-33(28-10-11-30-22-41(17-16-26(30)19-28)21-25-8-13-31(39)14-9-25)35(29-12-15-32-27(20-29)7-6-18-44-32)34(24(2)40-23)36(37(42)43)45-38(3,4)5/h8-15,19-20,36H,6-7,16-18,21-22H2,1-5H3,(H,42,43)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293323
PNG
(US10106504, Example 60)
Show SMILES Cc1cc(F)ccc1CN1CCc2cc(ccc2C1)-c1c(N)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C38H42FN3O4/c1-22-17-30(39)12-10-28(22)20-42-15-14-24-18-27(8-9-29(24)21-42)34-33(26-11-13-31-25(19-26)7-6-16-45-31)32(23(2)41-36(34)40)35(37(43)44)46-38(3,4)5/h8-13,17-19,35H,6-7,14-16,20-21H2,1-5H3,(H2,40,41)(H,43,44)/t35-/m0/s1
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n/an/an/an/a 3n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293284
PNG
(US10106504, Example 21)
Show SMILES Cc1nc(C)c(-c2ccc3CNCCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C31H36N2O4/c1-18-26(22-8-9-24-17-32-13-12-20(24)15-22)28(23-10-11-25-21(16-23)7-6-14-36-25)27(19(2)33-18)29(30(34)35)37-31(3,4)5/h8-11,15-16,29,32H,6-7,12-14,17H2,1-5H3,(H,34,35)/t29-/m0/s1
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n/an/an/an/a 7.77E+3n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293296
PNG
(US10106504, Example 33)
Show SMILES CN(CC1CCOCC1)Cc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc2CN(CCc2c1)c1cc(C)ncn1
Show InChI InChI=1S/C43H53N5O5/c1-27-20-37(45-26-44-27)48-16-13-30-21-32(9-10-34(30)24-48)39-35(25-47(6)23-29-14-18-51-19-15-29)46-28(2)38(41(42(49)50)53-43(3,4)5)40(39)33-11-12-36-31(22-33)8-7-17-52-36/h9-12,20-22,26,29,41H,7-8,13-19,23-25H2,1-6H3,(H,49,50)/t41-/m0/s1
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n/an/an/an/a 282n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293307
PNG
(US10106504, Example 44)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3F)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H37F2NO5/c1-21-31(24-9-13-28(14-10-24)42-18-16-23-8-12-27(37)20-29(23)38)33(26-11-15-30-25(19-26)7-6-17-43-30)32(22(2)39-21)34(35(40)41)44-36(3,4)5/h8-15,19-20,34H,6-7,16-18H2,1-5H3,(H,40,41)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293309
PNG
(US10106504, Example 46)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(C2=CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C35H42FNO4/c1-22-29(25-10-14-28(15-11-25)40-21-18-24-8-12-27(36)13-9-24)31(26-16-19-35(6,7)20-17-26)30(23(2)37-22)32(33(38)39)41-34(3,4)5/h8-16,32H,17-21H2,1-7H3,(H,38,39)/t32-/m0/s1
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n/an/an/an/a 61n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293310
PNG
(US10106504, Example 47)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2cc(F)c3OCC=Cc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H35F2NO5/c1-21-30(24-10-14-28(15-11-24)42-18-16-23-8-12-27(37)13-9-23)32(26-19-25-7-6-17-43-33(25)29(38)20-26)31(22(2)39-21)34(35(40)41)44-36(3,4)5/h6-15,19-20,34H,16-18H2,1-5H3,(H,40,41)/t34-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293268
PNG
(US10106504, Example 5)
Show SMILES Cc1ccc(cc1)-c1c([C@H](OC(C)(C)C)C(O)=O)c(C)nc(C)c1-c1ccc(OCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C33H34FNO4/c1-20-7-11-25(12-8-20)30-28(21(2)35-22(3)29(30)31(32(36)37)39-33(4,5)6)24-13-17-27(18-14-24)38-19-23-9-15-26(34)16-10-23/h7-18,31H,19H2,1-6H3,(H,36,37)/t31-/m0/s1
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n/an/an/an/a 550n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293277
PNG
(US10106504, Example 14)
Show SMILES Cc1nc(CO)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H38FNO6/c1-22-31(34(35(40)41)44-36(2,3)4)33(26-11-16-30-25(20-26)6-5-18-43-30)32(29(21-39)38-22)24-9-14-28(15-10-24)42-19-17-23-7-12-27(37)13-8-23/h7-16,20,34,39H,5-6,17-19,21H2,1-4H3,(H,40,41)/t34-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293314
PNG
(US10106504, Example 51)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1
Show InChI InChI=1S/C39H42ClFN2O4/c1-22-9-7-11-31(40)30(22)21-43-15-14-25-17-26(12-13-28(25)20-43)33-23(2)42-24(3)34(37(38(44)45)47-39(4,5)6)35(33)29-18-27-10-8-16-46-36(27)32(41)19-29/h7,9,11-13,17-19,37H,8,10,14-16,20-21H2,1-6H3,(H,44,45)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293330
PNG
(US10106504, Example 67)
Show SMILES Cc1cc(ncn1)N1CCc2cc(ccc2C1)-c1c(CCCC2CCOCC2)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C43H52N4O5/c1-27-22-37(45-26-44-27)47-18-15-30-23-32(11-12-34(30)25-47)39-35(10-6-8-29-16-20-50-21-17-29)46-28(2)38(41(42(48)49)52-43(3,4)5)40(39)33-13-14-36-31(24-33)9-7-19-51-36/h11-14,22-24,26,29,41H,6-10,15-21,25H2,1-5H3,(H,48,49)/t41-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293289
PNG
(US10106504, Example 26)
Show SMILES Cc1cccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2-c2ccc3OCCCc3c2)c1F
Show InChI InChI=1S/C39H43FN2O4/c1-23-9-7-10-31(36(23)40)22-42-17-16-26-19-28(12-13-30(26)21-42)33-24(2)41-25(3)34(37(38(43)44)46-39(4,5)6)35(33)29-14-15-32-27(20-29)11-8-18-45-32/h7,9-10,12-15,19-20,37H,8,11,16-18,21-22H2,1-6H3,(H,43,44)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293291
PNG
(US10106504, Example 28)
Show SMILES Cc1ccc(CN2CCc3cc(ccc3C2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2-c2ccc3OCCCc3c2)c(C)c1
Show InChI InChI=1S/C40H46N2O4/c1-24-10-11-32(25(2)19-24)22-42-17-16-28-20-30(12-13-33(28)23-42)35-26(3)41-27(4)36(38(39(43)44)46-40(5,6)7)37(35)31-14-15-34-29(21-31)9-8-18-45-34/h10-15,19-21,38H,8-9,16-18,22-23H2,1-7H3,(H,43,44)/t38-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293302
PNG
(US10106504, Example 39)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1S/C40H44F2N2O4/c1-22-10-8-12-32(41)31(22)21-44-16-15-26-18-27(13-14-28(26)20-44)34-24(3)43-25(4)35(38(39(45)46)48-40(5,6)7)36(34)30-19-33(42)37-29(23(30)2)11-9-17-47-37/h8,10,12-14,18-19,38H,9,11,15-17,20-21H2,1-7H3,(H,45,46)/t38-/m0/s1
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n/an/an/an/a 24n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293305
PNG
(US10106504, Example 42)
Show SMILES Cc1ccc(cc1)-c1c([C@H](OC(C)(C)C)C(O)=O)c(C)nc(C)c1-c1ccc2CN(Cc3ccccc3F)CCc2c1
Show InChI InChI=1S/C36H39FN2O3/c1-22-11-13-25(14-12-22)33-31(23(2)38-24(3)32(33)34(35(40)41)42-36(4,5)6)27-15-16-28-20-39(18-17-26(28)19-27)21-29-9-7-8-10-30(29)37/h7-16,19,34H,17-18,20-21H2,1-6H3,(H,40,41)/t34-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293266
PNG
(US10106504, Example 3)
Show SMILES COc1ccc(COc2ccc(cc2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2-c2ccc(C)cc2)cc1
Show InChI InChI=1S/C34H37NO5/c1-21-8-12-26(13-9-21)31-29(22(2)35-23(3)30(31)32(33(36)37)40-34(4,5)6)25-14-18-28(19-15-25)39-20-24-10-16-27(38-7)17-11-24/h8-19,32H,20H2,1-7H3,(H,36,37)/t32-/m0/s1
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n/an/an/an/a 550n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293270
PNG
(US10106504, Example 7)
Show SMILES CCOc1ccc(cc1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1S/C31H36FNO5/c1-8-36-21-13-11-20(12-14-21)25-18(3)33-19(4)26(29(30(34)35)38-31(5,6)7)27(25)23-16-24(32)28-22(17(23)2)10-9-15-37-28/h11-14,16,29H,8-10,15H2,1-7H3,(H,34,35)/t29-/m0/s1
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n/an/an/an/a 550n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293280
PNG
(US10106504, Example 17)
Show SMILES CCOCCOCc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc(OCCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C40H46FNO7/c1-6-45-22-23-46-25-33-36(28-11-16-32(17-12-28)47-21-19-27-9-14-31(41)15-10-27)37(30-13-18-34-29(24-30)8-7-20-48-34)35(26(2)42-33)38(39(43)44)49-40(3,4)5/h9-18,24,38H,6-8,19-23,25H2,1-5H3,(H,43,44)/t38-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293315
PNG
(US10106504, Example 52)
Show SMILES Cc1cc(ncn1)N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1
Show InChI InChI=1S/C36H39FN4O4/c1-20-14-29(39-19-38-20)41-12-11-23-15-24(9-10-26(23)18-41)30-21(2)40-22(3)31(34(35(42)43)45-36(4,5)6)32(30)27-16-25-8-7-13-44-33(25)28(37)17-27/h9-10,14-17,19,34H,7-8,11-13,18H2,1-6H3,(H,42,43)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293318
PNG
(US10106504, Example 55)
Show SMILES Cc1cc(ncn1)N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C36H40N4O4/c1-21-16-30(38-20-37-21)40-14-13-24-17-26(9-10-28(24)19-40)31-22(2)39-23(3)32(34(35(41)42)44-36(4,5)6)33(31)27-11-12-29-25(18-27)8-7-15-43-29/h9-12,16-18,20,34H,7-8,13-15,19H2,1-6H3,(H,41,42)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293321
PNG
(US10106504, Example 58)
Show SMILES Cc1cc(nc(C)n1)N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C37H42N4O4/c1-21-17-31(40-24(4)38-21)41-15-14-25-18-27(10-11-29(25)20-41)32-22(2)39-23(3)33(35(36(42)43)45-37(5,6)7)34(32)28-12-13-30-26(19-28)9-8-16-44-30/h10-13,17-19,35H,8-9,14-16,20H2,1-7H3,(H,42,43)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293327
PNG
(US10106504, Example 64)
Show SMILES COc1nccc(n1)N1CCc2cc(ccc2C1)-c1c(N)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C35H39N5O5/c1-20-28(31(33(41)42)45-35(2,3)4)29(23-10-11-26-22(18-23)7-6-16-44-26)30(32(36)38-20)24-8-9-25-19-40(15-13-21(25)17-24)27-12-14-37-34(39-27)43-5/h8-12,14,17-18,31H,6-7,13,15-16,19H2,1-5H3,(H2,36,38)(H,41,42)/t31-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293288
PNG
(US10106504, Example 25)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C39H43FN2O4/c1-23-9-7-11-32(40)31(23)22-42-17-16-26-19-28(12-13-30(26)21-42)34-24(2)41-25(3)35(37(38(43)44)46-39(4,5)6)36(34)29-14-15-33-27(20-29)10-8-18-45-33/h7,9,11-15,19-20,37H,8,10,16-18,21-22H2,1-6H3,(H,43,44)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293297
PNG
(US10106504, Example 34)
Show SMILES CN(CC1CCOCC1)Cc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc2CN(Cc3c(C)cccc3F)CCc2c1
Show InChI InChI=1S/C46H56FN3O5/c1-29-9-7-11-38(47)37(29)27-50-19-16-32-23-34(12-13-36(32)26-50)42-39(28-49(6)25-31-17-21-53-22-18-31)48-30(2)41(44(45(51)52)55-46(3,4)5)43(42)35-14-15-40-33(24-35)10-8-20-54-40/h7,9,11-15,23-24,31,44H,8,10,16-22,25-28H2,1-6H3,(H,51,52)/t44-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293308
PNG
(US10106504, Example 45)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccccc3F)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H38FNO5/c1-22-31(25-12-15-28(16-13-25)41-20-18-24-9-6-7-11-29(24)37)33(27-14-17-30-26(21-27)10-8-19-42-30)32(23(2)38-22)34(35(39)40)43-36(3,4)5/h6-7,9,11-17,21,34H,8,10,18-20H2,1-5H3,(H,39,40)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293265
PNG
(US10106504, Example 2)
Show SMILES COc1ccc(COc2ccc(cc2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H34ClNO5/c1-20-28(23-11-17-27(18-12-23)39-19-22-7-15-26(38-6)16-8-22)30(24-9-13-25(34)14-10-24)29(21(2)35-20)31(32(36)37)40-33(3,4)5/h7-18,31H,19H2,1-6H3,(H,36,37)/t31-/m0/s1
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n/an/an/an/a 73n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293276
PNG
(US10106504, Example 13)
Show SMILES CN(CC1CCOCC1)Cc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc(OCCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C43H51FN2O6/c1-28-38(41(42(47)48)52-43(2,3)4)40(33-12-17-37-32(25-33)7-6-21-51-37)39(36(45-28)27-46(5)26-30-18-22-49-23-19-30)31-10-15-35(16-11-31)50-24-20-29-8-13-34(44)14-9-29/h8-17,25,30,41H,6-7,18-24,26-27H2,1-5H3,(H,47,48)/t41-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293282
PNG
(US10106504, Example 19)
Show SMILES Cc1nc(C)c(-c2ccc3CN(CCc3c2)C(=O)OCc2ccccc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C39H42N2O6/c1-24-33(29-13-14-31-22-41(18-17-27(31)20-29)38(44)46-23-26-10-7-6-8-11-26)35(30-15-16-32-28(21-30)12-9-19-45-32)34(25(2)40-24)36(37(42)43)47-39(3,4)5/h6-8,10-11,13-16,20-21,36H,9,12,17-19,22-23H2,1-5H3,(H,42,43)/t36-/m0/s1
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n/an/an/an/a 69n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293322
PNG
(US10106504, Example 59)
Show SMILES Cc1nc(N)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C35H37FN2O5/c1-21-29(32(34(39)40)43-35(2,3)4)30(25-11-16-28-24(20-25)6-5-18-42-28)31(33(37)38-21)23-9-14-27(15-10-23)41-19-17-22-7-12-26(36)13-8-22/h7-16,20,32H,5-6,17-19H2,1-4H3,(H2,37,38)(H,39,40)/t32-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293329
PNG
(US10106504, Example 66)
Show SMILES Cc1nc(CCCC2CCOCC2)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C43H50FNO6/c1-28-38(41(42(46)47)51-43(2,3)4)40(33-14-19-37-32(27-33)8-6-23-50-37)39(36(45-28)9-5-7-29-20-24-48-25-21-29)31-12-17-35(18-13-31)49-26-22-30-10-15-34(44)16-11-30/h10-19,27,29,41H,5-9,20-26H2,1-4H3,(H,46,47)/t41-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293286
PNG
(US10106504, Example 23)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4F)CCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H41FN2O4/c1-23-33(27-12-13-29-21-41(17-16-25(29)19-27)22-30-9-6-7-11-31(30)39)35(28-14-15-32-26(20-28)10-8-18-44-32)34(24(2)40-23)36(37(42)43)45-38(3,4)5/h6-7,9,11-15,19-20,36H,8,10,16-18,21-22H2,1-5H3,(H,42,43)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293296
PNG
(US10106504, Example 33)
Show SMILES CN(CC1CCOCC1)Cc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc2CN(CCc2c1)c1cc(C)ncn1
Show InChI InChI=1S/C43H53N5O5/c1-27-20-37(45-26-44-27)48-16-13-30-21-32(9-10-34(30)24-48)39-35(25-47(6)23-29-14-18-51-19-15-29)46-28(2)38(41(42(49)50)53-43(3,4)5)40(39)33-11-12-36-31(22-33)8-7-17-52-36/h9-12,20-22,26,29,41H,7-8,13-19,23-25H2,1-6H3,(H,49,50)/t41-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293298
PNG
(US10106504, Example 35)
Show SMILES CN(CC1CCOCC1)Cc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc2CN(Cc3c(C)cccc3Cl)CCc2c1
Show InChI InChI=1S/C46H56ClN3O5/c1-29-9-7-11-38(47)37(29)27-50-19-16-32-23-34(12-13-36(32)26-50)42-39(28-49(6)25-31-17-21-53-22-18-31)48-30(2)41(44(45(51)52)55-46(3,4)5)43(42)35-14-15-40-33(24-35)10-8-20-54-40/h7,9,11-15,23-24,31,44H,8,10,16-22,25-28H2,1-6H3,(H,51,52)/t44-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293272
PNG
(US10106504, Example 9)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H38FNO5/c1-22-31(25-10-15-29(16-11-25)41-20-18-24-8-13-28(37)14-9-24)33(27-12-17-30-26(21-27)7-6-19-42-30)32(23(2)38-22)34(35(39)40)43-36(3,4)5/h8-17,21,34H,6-7,18-20H2,1-5H3,(H,39,40)/t34-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293274
PNG
(US10106504, Example 11)
Show SMILES Cc1nc(CNCC2CCOCC2)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C42H49FN2O6/c1-27-37(40(41(46)47)51-42(2,3)4)39(32-11-16-36-31(24-32)6-5-20-50-36)38(35(45-27)26-44-25-29-17-21-48-22-18-29)30-9-14-34(15-10-30)49-23-19-28-7-12-33(43)13-8-28/h7-16,24,29,40,44H,5-6,17-23,25-26H2,1-4H3,(H,46,47)/t40-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293275
PNG
(US10106504, Example 12)
Show SMILES COCCNCc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc(OCCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C39H45FN2O6/c1-25-34(37(38(43)44)48-39(2,3)4)36(29-12-17-33-28(23-29)7-6-20-47-33)35(32(42-25)24-41-19-22-45-5)27-10-15-31(16-11-27)46-21-18-26-8-13-30(40)14-9-26/h8-17,23,37,41H,6-7,18-22,24H2,1-5H3,(H,43,44)/t37-/m0/s1
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n/an/an/an/a 7n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293279
PNG
(US10106504, Example 16)
Show SMILES Cc1nc(COCC2COC2)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C40H44FNO7/c1-25-35(38(39(43)44)49-40(2,3)4)37(30-11-16-34-29(20-30)6-5-18-48-34)36(33(42-25)24-46-23-27-21-45-22-27)28-9-14-32(15-10-28)47-19-17-26-7-12-31(41)13-8-26/h7-16,20,27,38H,5-6,17-19,21-24H2,1-4H3,(H,43,44)/t38-/m0/s1
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n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293282
PNG
(US10106504, Example 19)
Show SMILES Cc1nc(C)c(-c2ccc3CN(CCc3c2)C(=O)OCc2ccccc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C39H42N2O6/c1-24-33(29-13-14-31-22-41(18-17-27(31)20-29)38(44)46-23-26-10-7-6-8-11-26)35(30-15-16-32-28(21-30)12-9-19-45-32)34(25(2)40-24)36(37(42)43)47-39(3,4)5/h6-8,10-11,13-16,20-21,36H,9,12,17-19,22-23H2,1-5H3,(H,42,43)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293316
PNG
(US10106504, Example 53)
Show SMILES Cc1nc(C)c(-c2ccc3CN(CCc3c2)c2ncnc3n(C)ncc23)c(-c2cc(F)c3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H39FN6O4/c1-20-29(23-9-10-25-18-44(12-11-22(25)14-23)35-27-17-41-43(6)34(27)39-19-40-35)31(26-15-24-8-7-13-47-32(24)28(38)16-26)30(21(2)42-20)33(36(45)46)48-37(3,4)5/h9-10,14-17,19,33H,7-8,11-13,18H2,1-6H3,(H,45,46)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293317
PNG
(US10106504, Example 54)
Show SMILES Cc1nc(C)c(-c2ccc3CN(CCc3c2)c2ncnc3n(C)ncc23)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H40N6O4/c1-21-30(25-9-10-27-19-43(14-13-23(27)16-25)35-28-18-40-42(6)34(28)38-20-39-35)32(26-11-12-29-24(17-26)8-7-15-46-29)31(22(2)41-21)33(36(44)45)47-37(3,4)5/h9-12,16-18,20,33H,7-8,13-15,19H2,1-6H3,(H,44,45)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293320
PNG
(US10106504, Example 57)
Show SMILES COc1nccc(n1)N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C36H40N4O5/c1-21-30(25-9-10-27-20-40(16-14-23(27)18-25)29-13-15-37-35(39-29)43-6)32(26-11-12-28-24(19-26)8-7-17-44-28)31(22(2)38-21)33(34(41)42)45-36(3,4)5/h9-13,15,18-19,33H,7-8,14,16-17,20H2,1-6H3,(H,41,42)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293323
PNG
(US10106504, Example 60)
Show SMILES Cc1cc(F)ccc1CN1CCc2cc(ccc2C1)-c1c(N)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C38H42FN3O4/c1-22-17-30(39)12-10-28(22)20-42-15-14-24-18-27(8-9-29(24)21-42)34-33(26-11-13-31-25(19-26)7-6-16-45-31)32(23(2)41-36(34)40)35(37(43)44)46-38(3,4)5/h8-13,17-19,35H,6-7,14-16,20-21H2,1-5H3,(H2,40,41)(H,43,44)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293324
PNG
(US10106504, Example 61)
Show SMILES Cc1nc(N)c(-c2ccc3CN(Cc4cccc(F)c4C)CCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H42FN3O4/c1-22-28(8-6-10-30(22)39)20-42-16-15-24-18-27(11-12-29(24)21-42)34-33(26-13-14-31-25(19-26)9-7-17-45-31)32(23(2)41-36(34)40)35(37(43)44)46-38(3,4)5/h6,8,10-14,18-19,35H,7,9,15-17,20-21H2,1-5H3,(H2,40,41)(H,43,44)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293285
PNG
(US10106504, Example 22)
Show SMILES CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C32H38N2O4/c1-19-27(23-9-10-25-18-34(6)14-13-21(25)16-23)29(24-11-12-26-22(17-24)8-7-15-37-26)28(20(2)33-19)30(31(35)36)38-32(3,4)5/h9-12,16-17,30H,7-8,13-15,18H2,1-6H3,(H,35,36)/t30-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293301
PNG
(US10106504, Example 38)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4ccccc4F)CCc3c2)c(-c2cc(F)c3OCCCc3c2C)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C39H42F2N2O4/c1-22-29-11-9-17-46-36(29)32(41)19-30(22)35-33(23(2)42-24(3)34(35)37(38(44)45)47-39(4,5)6)26-13-14-27-20-43(16-15-25(27)18-26)21-28-10-7-8-12-31(28)40/h7-8,10,12-14,18-19,37H,9,11,15-17,20-21H2,1-6H3,(H,44,45)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293309
PNG
(US10106504, Example 46)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(C2=CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C35H42FNO4/c1-22-29(25-10-14-28(15-11-25)40-21-18-24-8-12-27(36)13-9-24)31(26-16-19-35(6,7)20-17-26)30(23(2)37-22)32(33(38)39)41-34(3,4)5/h8-16,32H,17-21H2,1-7H3,(H,38,39)/t32-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293311
PNG
(US10106504, Example 48)
Show SMILES Cc1nc(C)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2cc(F)c3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C36H37F2NO5/c1-21-30(24-10-14-28(15-11-24)42-18-16-23-8-12-27(37)13-9-23)32(26-19-25-7-6-17-43-33(25)29(38)20-26)31(22(2)39-21)34(35(40)41)44-36(3,4)5/h8-15,19-20,34H,6-7,16-18H2,1-5H3,(H,40,41)/t34-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293265
PNG
(US10106504, Example 2)
Show SMILES COc1ccc(COc2ccc(cc2)-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H34ClNO5/c1-20-28(23-11-17-27(18-12-23)39-19-22-7-15-26(38-6)16-8-22)30(24-9-13-25(34)14-10-24)29(21(2)35-20)31(32(36)37)40-33(3,4)5/h7-18,31H,19H2,1-6H3,(H,36,37)/t31-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293275
PNG
(US10106504, Example 12)
Show SMILES COCCNCc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc(OCCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C39H45FN2O6/c1-25-34(37(38(43)44)48-39(2,3)4)36(29-12-17-33-28(23-29)7-6-20-47-33)35(32(42-25)24-41-19-22-45-5)27-10-15-31(16-11-27)46-21-18-26-8-13-30(40)14-9-26/h8-17,23,37,41H,6-7,18-22,24H2,1-5H3,(H,43,44)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293278
PNG
(US10106504, Example 15)
Show SMILES Cc1nc(COC2CCOCC2)c(-c2ccc(OCCc3ccc(F)cc3)cc2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C41H46FNO7/c1-26-36(39(40(44)45)50-41(2,3)4)38(30-11-16-35-29(24-30)6-5-20-48-35)37(34(43-26)25-49-33-18-21-46-22-19-33)28-9-14-32(15-10-28)47-23-17-27-7-12-31(42)13-8-27/h7-16,24,33,39H,5-6,17-23,25H2,1-4H3,(H,44,45)/t39-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293313
PNG
(US10106504, Example 50)
Show SMILES Cc1cc(F)ccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1
Show InChI InChI=1S/C39H42F2N2O4/c1-22-16-31(40)12-11-28(22)20-43-14-13-25-17-26(9-10-29(25)21-43)33-23(2)42-24(3)34(37(38(44)45)47-39(4,5)6)35(33)30-18-27-8-7-15-46-36(27)32(41)19-30/h9-12,16-19,37H,7-8,13-15,20-21H2,1-6H3,(H,44,45)/t37-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293317
PNG
(US10106504, Example 54)
Show SMILES Cc1nc(C)c(-c2ccc3CN(CCc3c2)c2ncnc3n(C)ncc23)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C37H40N6O4/c1-21-30(25-9-10-27-19-43(14-13-23(27)16-25)35-28-18-40-42(6)34(28)38-20-39-35)32(26-11-12-29-24(17-26)8-7-15-46-29)31(22(2)41-21)33(36(44)45)47-37(3,4)5/h9-12,16-18,20,33H,7-8,13-15,19H2,1-6H3,(H,44,45)/t33-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293331
PNG
(US10106504, Example 68)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(CCCC2CCOCC2)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1
Show InChI InChI=1S/C46H55FN2O5/c1-29-9-6-12-38(47)37(29)28-49-21-18-32-25-34(14-15-36(32)27-49)42-39(13-7-10-31-19-23-52-24-20-31)48-30(2)41(44(45(50)51)54-46(3,4)5)43(42)35-16-17-40-33(26-35)11-8-22-53-40/h6,9,12,14-17,25-26,31,44H,7-8,10-11,13,18-24,27-28H2,1-5H3,(H,50,51)/t44-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293287
PNG
(US10106504, Example 24)
Show SMILES Cc1nc(C)c(-c2ccc3CN(Cc4cccc(F)c4)CCc3c2)c(-c2ccc3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C38H41FN2O4/c1-23-33(28-11-12-30-22-41(16-15-26(30)19-28)21-25-8-6-10-31(39)18-25)35(29-13-14-32-27(20-29)9-7-17-44-32)34(24(2)40-23)36(37(42)43)45-38(3,4)5/h6,8,10-14,18-20,36H,7,9,15-17,21-22H2,1-5H3,(H,42,43)/t36-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293295
PNG
(US10106504, Example 32)
Show SMILES CN(CC1CCOCC1)Cc1nc(C)c([C@H](OC(C)(C)C)C(O)=O)c(-c2ccc3OCCCc3c2)c1-c1ccc2CN(CCc2c1)c1ncnc2n(C)ncc12
Show InChI InChI=1S/C44H53N7O5/c1-27-37(40(43(52)53)56-44(2,3)4)39(32-11-12-36-30(21-32)8-7-17-55-36)38(35(48-27)25-49(5)23-28-14-18-54-19-15-28)31-9-10-33-24-51(16-13-29(33)20-31)42-34-22-47-50(6)41(34)45-26-46-42/h9-12,20-22,26,28,40H,7-8,13-19,23-25H2,1-6H3,(H,52,53)/t40-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293302
PNG
(US10106504, Example 39)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1S/C40H44F2N2O4/c1-22-10-8-12-32(41)31(22)21-44-16-15-26-18-27(13-14-28(26)20-44)34-24(3)43-25(4)35(38(39(45)46)48-40(5,6)7)36(34)30-19-33(42)37-29(23(30)2)11-9-17-47-37/h8,10,12-14,18-19,38H,9,11,15-17,20-21H2,1-7H3,(H,45,46)/t38-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293303
PNG
(US10106504, Example 40)
Show SMILES Cc1ccccc1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1C
Show InChI InChI=1S/C40H45FN2O4/c1-23-11-8-9-12-29(23)21-43-17-16-27-19-28(14-15-30(27)22-43)34-25(3)42-26(4)35(38(39(44)45)47-40(5,6)7)36(34)32-20-33(41)37-31(24(32)2)13-10-18-46-37/h8-9,11-12,14-15,19-20,38H,10,13,16-18,21-22H2,1-7H3,(H,44,45)/t38-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293304
PNG
(US10106504, Example 41)
Show SMILES Cc1ccc(cc1)-c1c([C@H](OC(C)(C)C)C(O)=O)c(C)nc(C)c1-c1ccc2CN(Cc3c(C)cccc3F)CCc2c1
Show InChI InChI=1S/C37H41FN2O3/c1-22-11-13-26(14-12-22)34-32(24(3)39-25(4)33(34)35(36(41)42)43-37(5,6)7)28-15-16-29-20-40(18-17-27(29)19-28)21-30-23(2)9-8-10-31(30)38/h8-16,19,35H,17-18,20-21H2,1-7H3,(H,41,42)/t35-/m0/s1
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ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)
BDBM293264
PNG
(US10106504, Example 1)
Show SMILES Cc1nc(C)c(-c2cc(F)c3OCCCc3c2C)c(-c2cc(F)c3OCCCc3c2C)c1[C@H](OC(C)(C)C)C(O)=O
Show InChI InChI=1S/C33H37F2NO5/c1-16-20-10-8-12-39-29(20)24(34)14-22(16)26-18(3)36-19(4)27(31(32(37)38)41-33(5,6)7)28(26)23-15-25(35)30-21(17(23)2)11-9-13-40-30/h14-15,31H,8-13H2,1-7H3,(H,37,38)/t31-/m0/s1
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n/an/an/an/a 1.74E+3n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...


US Patent US10106504 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%