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Patent code US10106508

Compile Data Set for Download or QSAR
Found 94 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/a 6.30n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/a 22.5n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171908
PNG
(CHEMBL3805238 | US10106508, Compound I-38)
Show SMILES CCOc1cc2ncnc(Nc3cccc(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C18H16N4O5/c1-2-25-14-9-13-15(17-16(14)26-6-7-27-17)18(20-10-19-13)21-11-4-3-5-12(8-11)22(23)24/h3-5,8-10H,2,6-7H2,1H3,(H,19,20,21)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171908
PNG
(CHEMBL3805238 | US10106508, Compound I-38)
Show SMILES CCOc1cc2ncnc(Nc3cccc(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C18H16N4O5/c1-2-25-14-9-13-15(17-16(14)26-6-7-27-17)18(20-10-19-13)21-11-4-3-5-12(8-11)22(23)24/h3-5,8-10H,2,6-7H2,1H3,(H,19,20,21)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171910
PNG
(CHEMBL3806110 | US10106508, Compound I-30)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C19H17ClFN3O4/c1-25-4-5-26-15-9-14-16(18-17(15)27-6-7-28-18)19(23-10-22-14)24-11-2-3-13(21)12(20)8-11/h2-3,8-10H,4-7H2,1H3,(H,22,23,24)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50154255
PNG
(CHEMBL3774926 | US10106508, Compound II-1)
Show SMILES O=C1COc2cc3ncnc(Nc4cccc(c4)C#C)c3cc2N1CCCN1CCOCC1
Show InChI InChI=1S/C25H25N5O3/c1-2-18-5-3-6-19(13-18)28-25-20-14-22-23(15-21(20)26-17-27-25)33-16-24(31)30(22)8-4-7-29-9-11-32-12-10-29/h1,3,5-6,13-15,17H,4,7-12,16H2,(H,26,27,28)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171878
PNG
(CHEMBL3805039 | US10106508, Compound I-35)
Show SMILES CCOc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C20H17N3O3/c1-3-13-6-5-7-14(10-13)23-20-17-15(21-12-22-20)11-16(24-4-2)18-19(17)26-9-8-25-18/h1,5-7,10-12H,4,8-9H2,2H3,(H,21,22,23)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171877
PNG
(CHEMBL3806248 | US10106508, Compound I-34)
Show SMILES CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C18H15ClFN3O3/c1-2-24-14-8-13-15(17-16(14)25-5-6-26-17)18(22-9-21-13)23-10-3-4-12(20)11(19)7-10/h3-4,7-9H,2,5-6H2,1H3,(H,21,22,23)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM293354
PNG
(US10106508, Compound I-23 | US10106508, Example 23...)
Show SMILES Fc1cc(Nc2ncnc3cc(OC4CCOC4)c4OCCOc4c23)ccc1Cl
Show InChI InChI=1S/C20H17ClFN3O4/c21-13-2-1-11(7-14(13)22)25-20-17-15(23-10-24-20)8-16(29-12-3-4-26-9-12)18-19(17)28-6-5-27-18/h1-2,7-8,10,12H,3-6,9H2,(H,23,24,25)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171911
PNG
(CHEMBL3805461 | US10106508, Compound I-31)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C21H19N3O4/c1-3-14-5-4-6-15(11-14)24-21-18-16(22-13-23-21)12-17(26-8-7-25-2)19-20(18)28-10-9-27-19/h1,4-6,11-13H,7-10H2,2H3,(H,22,23,24)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171911
PNG
(CHEMBL3805461 | US10106508, Compound I-31)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C21H19N3O4/c1-3-14-5-4-6-15(11-14)24-21-18-16(22-13-23-21)12-17(26-8-7-25-2)19-20(18)28-10-9-27-19/h1,4-6,11-13H,7-10H2,2H3,(H,22,23,24)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171917
PNG
(CHEMBL3806200 | US10106508, Compound I-12)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(Cl)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C19H17ClN4O6/c1-27-4-5-28-15-9-13-16(18-17(15)29-6-7-30-18)19(22-10-21-13)23-11-2-3-12(20)14(8-11)24(25)26/h2-3,8-10H,4-7H2,1H3,(H,21,22,23)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171880
PNG
(CHEMBL3804868 | US10106508, Compound I-37)
Show SMILES CCOc1cc2ncnc(Nc3ccc(C)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C19H18ClN3O3/c1-3-24-15-9-14-16(18-17(15)25-6-7-26-18)19(22-10-21-14)23-12-5-4-11(2)13(20)8-12/h4-5,8-10H,3,6-7H2,1-2H3,(H,21,22,23)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171969
PNG
(CHEMBL3806213 | US10106508, Compound I-40)
Show SMILES Fc1ccc(Nc2ncnc3cc(OCC4CCCO4)c4OCCOc4c23)cc1Cl
Show InChI InChI=1S/C21H19ClFN3O4/c22-14-8-12(3-4-15(14)23)26-21-18-16(24-11-25-21)9-17(19-20(18)29-7-6-28-19)30-10-13-2-1-5-27-13/h3-4,8-9,11,13H,1-2,5-7,10H2,(H,24,25,26)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171879
PNG
(CHEMBL3805774 | US10106508, Compound I-36)
Show SMILES CCOc1cc2ncnc(Nc3cccc(OC)c3)c2c2OCCOc12
Show InChI InChI=1S/C19H19N3O4/c1-3-24-15-10-14-16(18-17(15)25-7-8-26-18)19(21-11-20-14)22-12-5-4-6-13(9-12)23-2/h4-6,9-11H,3,7-8H2,1-2H3,(H,20,21,22)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171961
PNG
(CHEMBL3805283 | US10106508, Compound I-7)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C19H17ClFN3O3/c1-10(2)27-15-8-14-16(18-17(15)25-5-6-26-18)19(23-9-22-14)24-11-3-4-13(21)12(20)7-11/h3-4,7-10H,5-6H2,1-2H3,(H,22,23,24)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171960
PNG
(CHEMBL3805509 | US10106508, Compound I-8)
Show SMILES CC(C)Oc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C21H19N3O3/c1-4-14-6-5-7-15(10-14)24-21-18-16(22-12-23-21)11-17(27-13(2)3)19-20(18)26-9-8-25-19/h1,5-7,10-13H,8-9H2,2-3H3,(H,22,23,24)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171910
PNG
(CHEMBL3806110 | US10106508, Compound I-30)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C19H17ClFN3O4/c1-25-4-5-26-15-9-14-16(18-17(15)27-6-7-28-18)19(23-10-22-14)24-11-2-3-13(21)12(20)8-11/h2-3,8-10H,4-7H2,1H3,(H,22,23,24)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171879
PNG
(CHEMBL3805774 | US10106508, Compound I-36)
Show SMILES CCOc1cc2ncnc(Nc3cccc(OC)c3)c2c2OCCOc12
Show InChI InChI=1S/C19H19N3O4/c1-3-24-15-10-14-16(18-17(15)25-7-8-26-18)19(21-11-20-14)22-12-5-4-6-13(9-12)23-2/h4-6,9-11H,3,7-8H2,1-2H3,(H,20,21,22)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50172007
PNG
(CHEMBL3805236 | US10106508, Compound I-28)
Show SMILES COc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C19H15N3O3/c1-3-12-5-4-6-13(9-12)22-19-16-14(20-11-21-19)10-15(23-2)17-18(16)25-8-7-24-17/h1,4-6,9-11H,7-8H2,2H3,(H,20,21,22)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171877
PNG
(CHEMBL3806248 | US10106508, Compound I-34)
Show SMILES CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C18H15ClFN3O3/c1-2-24-14-8-13-15(17-16(14)25-5-6-26-17)18(22-9-21-13)23-10-3-4-12(20)11(19)7-10/h3-4,7-9H,2,5-6H2,1H3,(H,21,22,23)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171961
PNG
(CHEMBL3805283 | US10106508, Compound I-7)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C19H17ClFN3O3/c1-10(2)27-15-8-14-16(18-17(15)25-5-6-26-18)19(23-9-22-14)24-11-3-4-13(21)12(20)7-11/h3-4,7-10H,5-6H2,1-2H3,(H,22,23,24)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171960
PNG
(CHEMBL3805509 | US10106508, Compound I-8)
Show SMILES CC(C)Oc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C21H19N3O3/c1-4-14-6-5-7-15(10-14)24-21-18-16(22-12-23-21)11-17(27-13(2)3)19-20(18)26-9-8-25-19/h1,5-7,10-13H,8-9H2,2-3H3,(H,22,23,24)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171915
PNG
(CHEMBL3805333 | US10106508, Compound I-10)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C19H17FN4O6/c1-27-4-5-28-15-9-13-16(18-17(15)29-6-7-30-18)19(22-10-21-13)23-11-2-3-12(20)14(8-11)24(25)26/h2-3,8-10H,4-7H2,1H3,(H,21,22,23)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171909
PNG
(CHEMBL3805859 | US10106508, Compound I-39)
Show SMILES CCOc1cc2ncnc(Nc3ccc(C)cc3)c2c2OCCOc12
Show InChI InChI=1S/C19H19N3O3/c1-3-23-15-10-14-16(18-17(15)24-8-9-25-18)19(21-11-20-14)22-13-6-4-12(2)5-7-13/h4-7,10-11H,3,8-9H2,1-2H3,(H,20,21,22)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171918
PNG
(CHEMBL3806170 | US10106508, Compound I-24)
Show SMILES C#Cc1cccc(Nc2ncnc3cc(OC4CCOC4)c4OCCOc4c23)c1
Show InChI InChI=1S/C22H19N3O4/c1-2-14-4-3-5-15(10-14)25-22-19-17(23-13-24-22)11-18(29-16-6-7-26-12-16)20-21(19)28-9-8-27-20/h1,3-5,10-11,13,16H,6-9,12H2,(H,23,24,25)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171968
PNG
(CHEMBL3805325 | US10106508, Compound I-41)
Show SMILES C#Cc1cccc(Nc2ncnc3cc(OCC4CCCO4)c4OCCOc4c23)c1
Show InChI InChI=1S/C23H21N3O4/c1-2-15-5-3-6-16(11-15)26-23-20-18(24-14-25-23)12-19(21-22(20)29-10-9-28-21)30-13-17-7-4-8-27-17/h1,3,5-6,11-12,14,17H,4,7-10,13H2,(H,24,25,26)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50172008
PNG
(CHEMBL3806292 | US10106508, Compound I-29)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C17H13ClFN3O3/c1-23-13-7-12-14(16-15(13)24-4-5-25-16)17(21-8-20-12)22-9-2-3-11(19)10(18)6-9/h2-3,6-8H,4-5H2,1H3,(H,20,21,22)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171880
PNG
(CHEMBL3804868 | US10106508, Compound I-37)
Show SMILES CCOc1cc2ncnc(Nc3ccc(C)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C19H18ClN3O3/c1-3-24-15-9-14-16(18-17(15)25-6-7-26-18)19(22-10-21-14)23-12-5-4-11(2)13(20)8-12/h4-5,8-10H,3,6-7H2,1-2H3,(H,21,22,23)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171878
PNG
(CHEMBL3805039 | US10106508, Compound I-35)
Show SMILES CCOc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C20H17N3O3/c1-3-13-6-5-7-14(10-13)23-20-17-15(21-12-22-20)11-16(24-4-2)18-19(17)26-9-8-25-18/h1,5-7,10-12H,4,8-9H2,2H3,(H,21,22,23)
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n/an/a<50n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171954
PNG
(CHEMBL3805775 | US10106508, Compound I-25)
Show SMILES COCC(C)Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C20H19ClFN3O4/c1-11(9-26-2)29-16-8-15-17(19-18(16)27-5-6-28-19)20(24-10-23-15)25-12-3-4-14(22)13(21)7-12/h3-4,7-8,10-11H,5-6,9H2,1-2H3,(H,23,24,25)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171964
PNG
(CHEMBL3805177 | US10106508, Compound I-4)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(Cl)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C19H17ClN4O5/c1-10(2)29-15-8-13-16(18-17(15)27-5-6-28-18)19(22-9-21-13)23-11-3-4-12(20)14(7-11)24(25)26/h3-4,7-10H,5-6H2,1-2H3,(H,21,22,23)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM293354
PNG
(US10106508, Compound I-23 | US10106508, Example 23...)
Show SMILES Fc1cc(Nc2ncnc3cc(OC4CCOC4)c4OCCOc4c23)ccc1Cl
Show InChI InChI=1S/C20H17ClFN3O4/c21-13-2-1-11(7-14(13)22)25-20-17-15(23-10-24-20)8-16(29-12-3-4-26-9-12)18-19(17)28-6-5-27-18/h1-2,7-8,10,12H,3-6,9H2,(H,23,24,25)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM293353
PNG
(US10106508, Compound I-22 | US10106508, Example 22...)
Show SMILES Fc1cc(Nc2ncnc3cc(OC4CCOCC4)c4OCCOc4c23)ccc1Cl
Show InChI InChI=1S/C21H19ClFN3O4/c22-14-2-1-12(9-15(14)23)26-21-18-16(24-11-25-21)10-17(19-20(18)29-8-7-28-19)30-13-3-5-27-6-4-13/h1-2,9-11,13H,3-8H2,(H,24,25,26)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50172056
PNG
(CHEMBL3806145 | US10106508, Compound I-21)
Show SMILES C#Cc1cccc(Nc2ncnc3cc(OC4CCOCC4)c4OCCOc4c23)c1
Show InChI InChI=1S/C23H21N3O4/c1-2-15-4-3-5-16(12-15)26-23-20-18(24-14-25-23)13-19(21-22(20)29-11-10-28-21)30-17-6-8-27-9-7-17/h1,3-5,12-14,17H,6-11H2,(H,24,25,26)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171968
PNG
(CHEMBL3805325 | US10106508, Compound I-41)
Show SMILES C#Cc1cccc(Nc2ncnc3cc(OCC4CCCO4)c4OCCOc4c23)c1
Show InChI InChI=1S/C23H21N3O4/c1-2-15-5-3-6-16(11-15)26-23-20-18(24-14-25-23)12-19(21-22(20)29-10-9-28-21)30-13-17-7-4-8-27-17/h1,3,5-6,11-12,14,17H,4,7-10,13H2,(H,24,25,26)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171966
PNG
(CHEMBL3805383 | US10106508, Compound I-2)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C19H17FN4O5/c1-10(2)29-15-8-13-16(18-17(15)27-5-6-28-18)19(22-9-21-13)23-11-3-4-12(20)14(7-11)24(25)26/h3-4,7-10H,5-6H2,1-2H3,(H,21,22,23)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171909
PNG
(CHEMBL3805859 | US10106508, Compound I-39)
Show SMILES CCOc1cc2ncnc(Nc3ccc(C)cc3)c2c2OCCOc12
Show InChI InChI=1S/C19H19N3O3/c1-3-23-15-10-14-16(18-17(15)24-8-9-25-18)19(21-11-20-14)22-13-6-4-12(2)5-7-13/h4-7,10-11H,3,8-9H2,1-2H3,(H,20,21,22)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171950
PNG
(CHEMBL3805584 | US10106508, Compound I-26)
Show SMILES COCC(C)Oc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C22H21N3O4/c1-4-15-6-5-7-16(10-15)25-22-19-17(23-13-24-22)11-18(29-14(2)12-26-3)20-21(19)28-9-8-27-20/h1,5-7,10-11,13-14H,8-9,12H2,2-3H3,(H,23,24,25)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171916
PNG
(CHEMBL3805299 | US10106508, Compound I-11)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(C)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H20N4O6/c1-12-3-4-13(9-15(12)24(25)26)23-20-17-14(21-11-22-20)10-16(28-6-5-27-2)18-19(17)30-8-7-29-18/h3-4,9-11H,5-8H2,1-2H3,(H,21,22,23)
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n/an/a<100n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50154277
PNG
(CHEMBL3774578 | US10106508, Compound II-3)
Show SMILES Cc1ccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)cc1Cl
Show InChI InChI=1S/C24H26ClN5O3/c1-16-3-4-17(11-19(16)25)28-24-18-12-21-22(13-20(18)26-15-27-24)33-14-23(31)30(21)6-2-5-29-7-9-32-10-8-29/h3-4,11-13,15H,2,5-10,14H2,1H3,(H,26,27,28)
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n/an/a<200n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50154278
PNG
(CHEMBL3775372 | US10106508, Compound II-5)
Show SMILES COc1ccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)cc1OC
Show InChI InChI=1S/C25H29N5O5/c1-32-21-5-4-17(12-23(21)33-2)28-25-18-13-20-22(14-19(18)26-16-27-25)35-15-24(31)30(20)7-3-6-29-8-10-34-11-9-29/h4-5,12-14,16H,3,6-11,15H2,1-2H3,(H,26,27,28)
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n/an/a<200n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171912
PNG
(CHEMBL3806005 | US10106508, Compound I-32)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)cc3)c2c2OCCOc12
Show InChI InChI=1S/C19H18FN3O4/c1-24-6-7-25-15-10-14-16(18-17(15)26-8-9-27-18)19(22-11-21-14)23-13-4-2-12(20)3-5-13/h2-5,10-11H,6-9H2,1H3,(H,21,22,23)
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n/an/a<200n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171965
PNG
(CHEMBL3805089 | US10106508, Compound I-3)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(C)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H20N4O5/c1-11(2)29-16-9-14-17(19-18(16)27-6-7-28-19)20(22-10-21-14)23-13-5-4-12(3)15(8-13)24(25)26/h4-5,8-11H,6-7H2,1-3H3,(H,21,22,23)
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n/an/a<200n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50154286
PNG
(CHEMBL3774910 | US10106508, Compound II-4)
Show SMILES COc1cccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)c1
Show InChI InChI=1S/C24H27N5O4/c1-31-18-5-2-4-17(12-18)27-24-19-13-21-22(14-20(19)25-16-26-24)33-15-23(30)29(21)7-3-6-28-8-10-32-11-9-28/h2,4-5,12-14,16H,3,6-11,15H2,1H3,(H,25,26,27)
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n/an/a<200n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171913
PNG
(CHEMBL3806066 | US10106508, Compound I-33)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(OC)c3)c2c2OCCOc12
Show InChI InChI=1S/C20H21N3O5/c1-24-6-7-26-16-11-15-17(19-18(16)27-8-9-28-19)20(22-12-21-15)23-13-4-3-5-14(10-13)25-2/h3-5,10-12H,6-9H2,1-2H3,(H,21,22,23)
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n/an/a<200n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM293358
PNG
(US10106508, Compound I-27 | US10106508, Example 27...)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C26H23ClFN3O4/c1-15(2)35-22-12-20-23(25-24(22)32-8-9-33-25)26(30-14-29-20)31-18-6-7-21(19(27)11-18)34-13-16-4-3-5-17(28)10-16/h3-7,10-12,14-15H,8-9,13H2,1-2H3,(H,29,30,31)
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n/an/a<200n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50154284
PNG
(CHEMBL3775664 | US10106508, Compound II-2)
Show SMILES Fc1ccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)cc1Cl
Show InChI InChI=1S/C23H23ClFN5O3/c24-17-10-15(2-3-18(17)25)28-23-16-11-20-21(12-19(16)26-14-27-23)33-13-22(31)30(20)5-1-4-29-6-8-32-9-7-29/h2-3,10-12,14H,1,4-9,13H2,(H,26,27,28)
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n/an/a<200n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171956
PNG
(CHEMBL3805654 | US10106508, Compound I-19)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C21H19FN4O4/c1-3-27-12(2)30-17-9-16-18(20-19(17)28-6-7-29-20)21(25-11-24-16)26-14-4-5-15(22)13(8-14)10-23/h4-5,8-9,11-12H,3,6-7H2,1-2H3,(H,24,25,26)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171958
PNG
(CHEMBL3806172 | US10106508, Compound I-16)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H19FN4O6/c1-3-28-11(2)31-16-9-14-17(19-18(16)29-6-7-30-19)20(23-10-22-14)24-12-4-5-13(21)15(8-12)25(26)27/h4-5,8-11H,3,6-7H2,1-2H3,(H,22,23,24)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171950
PNG
(CHEMBL3805584 | US10106508, Compound I-26)
Show SMILES COCC(C)Oc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C22H21N3O4/c1-4-15-6-5-7-16(10-15)25-22-19-17(23-13-24-22)11-18(29-14(2)12-26-3)20-21(19)28-9-8-27-20/h1,5-7,10-11,13-14H,8-9,12H2,2-3H3,(H,23,24,25)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171963
PNG
(CHEMBL3805949 | US10106508, Compound I-5)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C20H17FN4O3/c1-11(2)28-16-8-15-17(19-18(16)26-5-6-27-19)20(24-10-23-15)25-13-3-4-14(21)12(7-13)9-22/h3-4,7-8,10-11H,5-6H2,1-2H3,(H,23,24,25)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50154255
PNG
(CHEMBL3774926 | US10106508, Compound II-1)
Show SMILES O=C1COc2cc3ncnc(Nc4cccc(c4)C#C)c3cc2N1CCCN1CCOCC1
Show InChI InChI=1S/C25H25N5O3/c1-2-18-5-3-6-19(13-18)28-25-20-14-22-23(15-21(20)26-17-27-25)33-16-24(31)30(22)8-4-7-29-9-11-32-12-10-29/h1,3,5-6,13-15,17H,4,7-12,16H2,(H,26,27,28)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171918
PNG
(CHEMBL3806170 | US10106508, Compound I-24)
Show SMILES C#Cc1cccc(Nc2ncnc3cc(OC4CCOC4)c4OCCOc4c23)c1
Show InChI InChI=1S/C22H19N3O4/c1-2-14-4-3-5-15(10-14)25-22-19-17(23-13-24-22)11-18(29-16-6-7-26-12-16)20-21(19)28-9-8-27-20/h1,3-5,10-11,13,16H,6-9,12H2,(H,23,24,25)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171957
PNG
(CHEMBL3805260 | US10106508, Compound I-18)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(C)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C21H22N4O6/c1-4-28-13(3)31-17-10-15-18(20-19(17)29-7-8-30-20)21(23-11-22-15)24-14-6-5-12(2)16(9-14)25(26)27/h5-6,9-11,13H,4,7-8H2,1-3H3,(H,22,23,24)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171958
PNG
(CHEMBL3806172 | US10106508, Compound I-16)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H19FN4O6/c1-3-28-11(2)31-16-9-14-17(19-18(16)29-6-7-30-19)20(23-10-22-14)24-12-4-5-13(21)15(8-12)25(26)27/h4-5,8-11H,3,6-7H2,1-2H3,(H,22,23,24)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM293348
PNG
(US10106508, Compound I-17 | US10106508, Example 17...)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(Cl)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H19ClN4O6/c1-3-28-11(2)31-16-9-14-17(19-18(16)29-6-7-30-19)20(23-10-22-14)24-12-4-5-13(21)15(8-12)25(26)27/h4-5,8-11H,3,6-7H2,1-2H3,(H,22,23,24)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171954
PNG
(CHEMBL3805775 | US10106508, Compound I-25)
Show SMILES COCC(C)Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C20H19ClFN3O4/c1-11(9-26-2)29-16-8-15-17(19-18(16)27-5-6-28-19)20(24-10-23-15)25-12-3-4-14(22)13(21)7-12/h3-4,7-8,10-11H,5-6,9H2,1-2H3,(H,23,24,25)
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n/an/a<300n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171962
PNG
(CHEMBL3806321 | US10106508, Compound I-6)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(C)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C21H20N4O3/c1-12(2)28-17-9-16-18(20-19(17)26-6-7-27-20)21(24-11-23-16)25-15-5-4-13(3)14(8-15)10-22/h4-5,8-9,11-12H,6-7H2,1-3H3,(H,23,24,25)
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n/an/a<400n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171970
PNG
(CHEMBL3805280 | US10106508, Compound I-13)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C20H17FN4O4/c1-26-4-5-27-16-9-15-17(19-18(16)28-6-7-29-19)20(24-11-23-15)25-13-2-3-14(21)12(8-13)10-22/h2-3,8-9,11H,4-7H2,1H3,(H,23,24,25)
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n/an/a<500n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171967
PNG
(CHEMBL3805475 | US10106508, Compound I-1)
Show SMILES COc1ccc(Nc2ncnc3cc(OC(C)C)c4OCCOc4c23)cc1[N+]([O-])=O
Show InChI InChI=1S/C20H20N4O6/c1-11(2)30-16-9-13-17(19-18(16)28-6-7-29-19)20(22-10-21-13)23-12-4-5-15(27-3)14(8-12)24(25)26/h4-5,8-11H,6-7H2,1-3H3,(H,21,22,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171970
PNG
(CHEMBL3805280 | US10106508, Compound I-13)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C20H17FN4O4/c1-26-4-5-27-16-9-15-17(19-18(16)28-6-7-29-19)20(24-11-23-15)25-13-2-3-14(21)12(8-13)10-22/h2-3,8-9,11H,4-7H2,1H3,(H,23,24,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50172056
PNG
(CHEMBL3806145 | US10106508, Compound I-21)
Show SMILES C#Cc1cccc(Nc2ncnc3cc(OC4CCOCC4)c4OCCOc4c23)c1
Show InChI InChI=1S/C23H21N3O4/c1-2-15-4-3-5-16(12-15)26-23-20-18(24-14-25-23)13-19(21-22(20)29-11-10-28-21)30-17-6-8-27-9-7-17/h1,3-5,12-14,17H,6-11H2,(H,24,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171912
PNG
(CHEMBL3806005 | US10106508, Compound I-32)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)cc3)c2c2OCCOc12
Show InChI InChI=1S/C19H18FN3O4/c1-24-6-7-25-15-10-14-16(18-17(15)26-8-9-27-18)19(22-11-21-14)23-13-4-2-12(20)3-5-13/h2-5,10-11H,6-9H2,1H3,(H,21,22,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171969
PNG
(CHEMBL3806213 | US10106508, Compound I-40)
Show SMILES Fc1ccc(Nc2ncnc3cc(OCC4CCCO4)c4OCCOc4c23)cc1Cl
Show InChI InChI=1S/C21H19ClFN3O4/c22-14-8-12(3-4-15(14)23)26-21-18-16(24-11-25-21)9-17(19-20(18)29-7-6-28-19)30-10-13-2-1-5-27-13/h3-4,8-9,11,13H,1-2,5-7,10H2,(H,24,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50154286
PNG
(CHEMBL3774910 | US10106508, Compound II-4)
Show SMILES COc1cccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)c1
Show InChI InChI=1S/C24H27N5O4/c1-31-18-5-2-4-17(12-18)27-24-19-13-21-22(14-20(19)25-16-26-24)33-15-23(30)29(21)7-3-6-28-8-10-32-11-9-28/h2,4-5,12-14,16H,3,6-11,15H2,1H3,(H,25,26,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171967
PNG
(CHEMBL3805475 | US10106508, Compound I-1)
Show SMILES COc1ccc(Nc2ncnc3cc(OC(C)C)c4OCCOc4c23)cc1[N+]([O-])=O
Show InChI InChI=1S/C20H20N4O6/c1-11(2)30-16-9-13-17(19-18(16)28-6-7-29-19)20(22-10-21-13)23-12-4-5-15(27-3)14(8-12)24(25)26/h4-5,8-11H,6-7H2,1-3H3,(H,21,22,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171917
PNG
(CHEMBL3806200 | US10106508, Compound I-12)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(Cl)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C19H17ClN4O6/c1-27-4-5-28-15-9-13-16(18-17(15)29-6-7-30-18)19(22-10-21-13)23-11-2-3-12(20)14(8-11)24(25)26/h2-3,8-10H,4-7H2,1H3,(H,21,22,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50172007
PNG
(CHEMBL3805236 | US10106508, Compound I-28)
Show SMILES COc1cc2ncnc(Nc3cccc(c3)C#C)c2c2OCCOc12
Show InChI InChI=1S/C19H15N3O3/c1-3-12-5-4-6-13(9-12)22-19-16-14(20-11-21-19)10-15(23-2)17-18(16)25-8-7-24-17/h1,4-6,9-11H,7-8H2,2H3,(H,20,21,22)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171914
PNG
(CHEMBL3805491 | US10106508, Compound I-9)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(OC)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H20N4O7/c1-27-5-6-29-16-10-13-17(19-18(16)30-7-8-31-19)20(22-11-21-13)23-12-3-4-15(28-2)14(9-12)24(25)26/h3-4,9-11H,5-8H2,1-2H3,(H,21,22,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171915
PNG
(CHEMBL3805333 | US10106508, Compound I-10)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C19H17FN4O6/c1-27-4-5-28-15-9-13-16(18-17(15)29-6-7-30-18)19(22-10-21-13)23-11-2-3-12(20)14(8-11)24(25)26/h2-3,8-10H,4-7H2,1H3,(H,21,22,23)
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BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171916
PNG
(CHEMBL3805299 | US10106508, Compound I-11)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(C)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H20N4O6/c1-12-3-4-13(9-15(12)24(25)26)23-20-17-14(21-11-22-20)10-16(28-6-5-27-2)18-19(17)30-8-7-29-18/h3-4,9-11H,5-8H2,1-2H3,(H,21,22,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171965
PNG
(CHEMBL3805089 | US10106508, Compound I-3)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(C)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H20N4O5/c1-11(2)29-16-9-14-17(19-18(16)27-6-7-28-19)20(22-10-21-14)23-13-5-4-12(3)15(8-13)24(25)26/h4-5,8-11H,6-7H2,1-3H3,(H,21,22,23)
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BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171963
PNG
(CHEMBL3805949 | US10106508, Compound I-5)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C20H17FN4O3/c1-11(2)28-16-8-15-17(19-18(16)26-5-6-27-19)20(24-10-23-15)25-13-3-4-14(21)12(7-13)9-22/h3-4,7-8,10-11H,5-6H2,1-2H3,(H,23,24,25)
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BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171959
PNG
(CHEMBL3805402 | US10106508, Compound I-15)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(OC)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C21H22N4O7/c1-4-29-12(2)32-17-10-14-18(20-19(17)30-7-8-31-20)21(23-11-22-14)24-13-5-6-16(28-3)15(9-13)25(26)27/h5-6,9-12H,4,7-8H2,1-3H3,(H,22,23,24)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50154277
PNG
(CHEMBL3774578 | US10106508, Compound II-3)
Show SMILES Cc1ccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)cc1Cl
Show InChI InChI=1S/C24H26ClN5O3/c1-16-3-4-17(11-19(16)25)28-24-18-12-21-22(13-20(18)26-15-27-24)33-14-23(31)30(21)6-2-5-29-7-9-32-10-8-29/h3-4,11-13,15H,2,5-10,14H2,1H3,(H,26,27,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171962
PNG
(CHEMBL3806321 | US10106508, Compound I-6)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(C)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C21H20N4O3/c1-12(2)28-17-9-16-18(20-19(17)26-6-7-27-20)21(24-11-23-16)25-15-5-4-13(3)14(8-15)10-22/h4-5,8-9,11-12H,6-7H2,1-3H3,(H,23,24,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM293353
PNG
(US10106508, Compound I-22 | US10106508, Example 22...)
Show SMILES Fc1cc(Nc2ncnc3cc(OC4CCOCC4)c4OCCOc4c23)ccc1Cl
Show InChI InChI=1S/C21H19ClFN3O4/c22-14-2-1-12(9-15(14)23)26-21-18-16(24-11-25-21)10-17(19-20(18)29-8-7-28-19)30-13-3-5-27-6-4-13/h1-2,9-11,13H,3-8H2,(H,24,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50172008
PNG
(CHEMBL3806292 | US10106508, Compound I-29)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C17H13ClFN3O3/c1-23-13-7-12-14(16-15(13)24-4-5-25-16)17(21-8-20-12)22-9-2-3-11(19)10(18)6-9/h2-3,6-8H,4-5H2,1H3,(H,20,21,22)
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BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171913
PNG
(CHEMBL3806066 | US10106508, Compound I-33)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(OC)c3)c2c2OCCOc12
Show InChI InChI=1S/C20H21N3O5/c1-24-6-7-26-16-11-15-17(19-18(16)27-8-9-28-19)20(22-12-21-15)23-13-4-3-5-14(10-13)25-2/h3-5,10-12H,6-9H2,1-2H3,(H,21,22,23)
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BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171966
PNG
(CHEMBL3805383 | US10106508, Compound I-2)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C19H17FN4O5/c1-10(2)29-15-8-13-16(18-17(15)27-5-6-28-18)19(22-9-21-13)23-11-3-4-12(20)14(7-11)24(25)26/h3-4,7-10H,5-6H2,1-2H3,(H,21,22,23)
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BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171964
PNG
(CHEMBL3805177 | US10106508, Compound I-4)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(Cl)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C19H17ClN4O5/c1-10(2)29-15-8-13-16(18-17(15)27-5-6-28-18)19(22-9-21-13)23-11-3-4-12(20)14(7-11)24(25)26/h3-4,7-10H,5-6H2,1-2H3,(H,21,22,23)
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BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM293345
PNG
(US10106508, Compound I-14 | US10106508, Example 14...)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(C)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C21H20N4O4/c1-13-3-4-15(9-14(13)11-22)25-21-18-16(23-12-24-21)10-17(27-6-5-26-2)19-20(18)29-8-7-28-19/h3-4,9-10,12H,5-8H2,1-2H3,(H,23,24,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171957
PNG
(CHEMBL3805260 | US10106508, Compound I-18)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(C)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C21H22N4O6/c1-4-28-13(3)31-17-10-15-18(20-19(17)29-7-8-30-20)21(23-11-22-15)24-14-6-5-12(2)16(9-14)25(26)27/h5-6,9-11,13H,4,7-8H2,1-3H3,(H,22,23,24)
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BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171956
PNG
(CHEMBL3805654 | US10106508, Compound I-19)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C21H19FN4O4/c1-3-27-12(2)30-17-9-16-18(20-19(17)28-6-7-29-20)21(25-11-24-16)26-14-4-5-15(22)13(8-14)10-23/h4-5,8-9,11-12H,3,6-7H2,1-2H3,(H,24,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171955
PNG
(CHEMBL3805618 | US10106508, Compound I-20)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(C)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C22H22N4O4/c1-4-27-14(3)30-18-10-17-19(21-20(18)28-7-8-29-21)22(25-12-24-17)26-16-6-5-13(2)15(9-16)11-23/h5-6,9-10,12,14H,4,7-8H2,1-3H3,(H,24,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM293345
PNG
(US10106508, Compound I-14 | US10106508, Example 14...)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(C)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C21H20N4O4/c1-13-3-4-15(9-14(13)11-22)25-21-18-16(23-12-24-21)10-17(27-6-5-26-2)19-20(18)29-8-7-28-19/h3-4,9-10,12H,5-8H2,1-2H3,(H,23,24,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171959
PNG
(CHEMBL3805402 | US10106508, Compound I-15)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(OC)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C21H22N4O7/c1-4-29-12(2)32-17-10-14-18(20-19(17)30-7-8-31-20)21(23-11-22-14)24-13-5-6-16(28-3)15(9-13)25(26)27/h5-6,9-12H,4,7-8H2,1-3H3,(H,22,23,24)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM293358
PNG
(US10106508, Compound I-27 | US10106508, Example 27...)
Show SMILES CC(C)Oc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c2OCCOc12
Show InChI InChI=1S/C26H23ClFN3O4/c1-15(2)35-22-12-20-23(25-24(22)32-8-9-33-25)26(30-14-29-20)31-18-6-7-21(19(27)11-18)34-13-16-4-3-5-17(28)10-16/h3-7,10-12,14-15H,8-9,13H2,1-2H3,(H,29,30,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50154284
PNG
(CHEMBL3775664 | US10106508, Compound II-2)
Show SMILES Fc1ccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)cc1Cl
Show InChI InChI=1S/C23H23ClFN5O3/c24-17-10-15(2-3-18(17)25)28-23-16-11-20-21(12-19(16)26-14-27-23)33-13-22(31)30(20)5-1-4-29-6-8-32-9-7-29/h2-3,10-12,14H,1,4-9,13H2,(H,26,27,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50171914
PNG
(CHEMBL3805491 | US10106508, Compound I-9)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(OC)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H20N4O7/c1-27-5-6-29-16-10-13-17(19-18(16)30-7-8-31-19)20(22-11-21-13)23-12-3-4-15(28-2)14(9-12)24(25)26/h3-4,9-11H,5-8H2,1-2H3,(H,21,22,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM293348
PNG
(US10106508, Compound I-17 | US10106508, Example 17...)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(Cl)c(c3)[N+]([O-])=O)c2c2OCCOc12
Show InChI InChI=1S/C20H19ClN4O6/c1-3-28-11(2)31-16-9-14-17(19-18(16)29-6-7-30-19)20(23-10-22-14)24-12-4-5-13(21)15(8-12)25(26)27/h4-5,8-11H,3,6-7H2,1-2H3,(H,22,23,24)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50171955
PNG
(CHEMBL3805618 | US10106508, Compound I-20)
Show SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(C)c(c3)C#N)c2c2OCCOc12
Show InChI InChI=1S/C22H22N4O4/c1-4-27-14(3)30-18-10-17-19(21-20(18)28-7-8-29-21)22(25-12-24-17)26-16-6-5-13(2)15(9-16)11-23/h5-6,9-10,12,14H,4,7-8H2,1-3H3,(H,24,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (T790M)


(Homo sapiens (Human))
BDBM50154278
PNG
(CHEMBL3775372 | US10106508, Compound II-5)
Show SMILES COc1ccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)cc1OC
Show InChI InChI=1S/C25H29N5O5/c1-32-21-5-4-17(12-23(21)33-2)28-25-18-13-20-22(14-19(18)26-16-27-25)35-15-24(31)30(20)7-3-6-29-8-10-34-11-9-29/h4-5,12-14,16H,3,6-11,15H2,1-2H3,(H,26,27,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

US Patent


Assay Description
The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...


US Patent US10106508 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%