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Patent code US10106534

Compile Data Set for Download or QSAR

Found 274 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
jmjd3


(Homo sapiens (Human))
BDBM293686
PNG
(3-({[7-(furan-3-yl)-3,4-dihydro-2H-1-benzopyran-4-...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)-c1ccoc1
Show InChI InChI=1S/C20H18N2O4/c23-20(24)17-3-6-21-11-18(17)22-10-14-5-8-26-19-9-13(1-2-16(14)19)15-4-7-25-12-15/h1-4,6-7,9,11-12,14,22H,5,8,10H2,(H,23,24)
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n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293831
PNG
(3-({[(1R)-6-[methyl(pyridin-4-yl)amino]-1,2,3,4- |...)
Show SMILES CN(c1ccncc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C23H24N4O2/c1-27(18-7-10-24-11-8-18)19-5-6-20-16(13-19)3-2-4-17(20)14-26-22-15-25-12-9-21(22)23(28)29/h5-13,15,17,26H,2-4,14H2,1H3,(H,28,29)/t17-/m0/s1
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n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293691
PNG
(3-({[(4S)-7-(thiophen-3-yl)-3,4-dihydro-2H-1-benzo...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C20H18N2O3S/c23-20(24)17-3-6-21-11-18(17)22-10-14-4-7-25-19-9-13(1-2-16(14)19)15-5-8-26-12-15/h1-3,5-6,8-9,11-12,14,22H,4,7,10H2,(H,23,24)/t14-/m1/s1
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n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293863
PNG
(3-({[(4R)-7-{methyl[4-(1-methylpiperidin-4-yl)phen...)
Show SMILES CN(c1ccc(cc1)C1CCN(C)CC1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C29H34N4O3/c1-32-14-10-21(11-15-32)20-3-5-23(6-4-20)33(2)24-7-8-25-22(12-16-36-28(25)17-24)18-31-27-19-30-13-9-26(27)29(34)35/h3-9,13,17,19,21-22,31H,10-12,14-16,18H2,1-2H3,(H,34,35)/t22-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293670
PNG
(3-({[(1R)-6-[methyl(pyridin-3-yl)amino]-1,2,3,4- |...)
Show SMILES CN(c1cccnc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C23H24N4O2/c1-27(19-6-3-10-24-14-19)18-7-8-20-16(12-18)4-2-5-17(20)13-26-22-15-25-11-9-21(22)23(28)29/h3,6-12,14-15,17,26H,2,4-5,13H2,1H3,(H,28,29)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293836
PNG
(3-({[(4R)-7-[(4-methoxyphenyl)(methyl)amino]-3,4-d...)
Show SMILES COc1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C24H25N3O4/c1-27(17-3-6-19(30-2)7-4-17)18-5-8-20-16(10-12-31-23(20)13-18)14-26-22-15-25-11-9-21(22)24(28)29/h3-9,11,13,15-16,26H,10,12,14H2,1-2H3,(H,28,29)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293803
PNG
(3-({[(4R)-7-[methyl(5-methylpyridin-2-yl)amino]-3,...)
Show SMILES CN(c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1)c1ccc(C)cn1
Show InChI InChI=1S/C23H24N4O3/c1-15-3-6-22(26-12-15)27(2)17-4-5-18-16(8-10-30-21(18)11-17)13-25-20-14-24-9-7-19(20)23(28)29/h3-7,9,11-12,14,16,25H,8,10,13H2,1-2H3,(H,28,29)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293862
PNG
(3-({[(4R)-7-{methyl[4-(1-methyl-1,2,3,6-tetrahydro...)
Show SMILES CN(c1ccc(cc1)C1=CCN(C)CC1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C29H32N4O3/c1-32-14-10-21(11-15-32)20-3-5-23(6-4-20)33(2)24-7-8-25-22(12-16-36-28(25)17-24)18-31-27-19-30-13-9-26(27)29(34)35/h3-10,13,17,19,22,31H,11-12,14-16,18H2,1-2H3,(H,34,35)/t22-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293666
PNG
(3-({[(1R)-6-[(4-fluorophenyl)(methyl)amino]-1,2,3,...)
Show SMILES CN(c1ccc(F)cc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C24H24FN3O2/c1-28(19-7-5-18(25)6-8-19)20-9-10-21-16(13-20)3-2-4-17(21)14-27-23-15-26-12-11-22(23)24(29)30/h5-13,15,17,27H,2-4,14H2,1H3,(H,29,30)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293674
PNG
(3-({[7-(1,2,3,4-tetrahydroquinolin-1-yl)-3,4-dihyd...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)N1CCCc2ccccc12
Show InChI InChI=1S/C25H25N3O3/c29-25(30)21-9-11-26-16-22(21)27-15-18-10-13-31-24-14-19(7-8-20(18)24)28-12-3-5-17-4-1-2-6-23(17)28/h1-2,4,6-9,11,14,16,18,27H,3,5,10,12-13,15H2,(H,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293680
PNG
(3-({[(4R)-7-[methyl(4-methylphenyl)amino]-3,4-dihy...)
Show SMILES CN(c1ccc(C)cc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C24H25N3O3/c1-16-3-5-18(6-4-16)27(2)19-7-8-20-17(10-12-30-23(20)13-19)14-26-22-15-25-11-9-21(22)24(28)29/h3-9,11,13,15,17,26H,10,12,14H2,1-2H3,(H,28,29)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293684
PNG
(3-[({2-[methyl(phenyl)amino]-5,6,7,8-tetrahydroqui...)
Show SMILES CN(c1ccccc1)c1ccc2C(CNc3cnccc3C(O)=O)CCCc2n1
Show InChI InChI=1S/C23H24N4O2/c1-27(17-7-3-2-4-8-17)22-11-10-18-16(6-5-9-20(18)26-22)14-25-21-15-24-13-12-19(21)23(28)29/h2-4,7-8,10-13,15-16,25H,5-6,9,14H2,1H3,(H,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293687
PNG
(3-({[(4S)-7-(3-methylphenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES Cc1cccc(c1)-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H22N2O3/c1-15-3-2-4-16(11-15)17-5-6-19-18(8-10-28-22(19)12-17)13-25-21-14-24-9-7-20(21)23(26)27/h2-7,9,11-12,14,18,25H,8,10,13H2,1H3,(H,26,27)/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293690
PNG
(3-({[(4R)-7-(4-methylphenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES Cc1ccc(cc1)-c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H22N2O3/c1-15-2-4-16(5-3-15)17-6-7-19-18(9-11-28-22(19)12-17)13-25-21-14-24-10-8-20(21)23(26)27/h2-8,10,12,14,18,25H,9,11,13H2,1H3,(H,26,27)/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293703
PNG
(3-({[(4R)-7-(2-chloro-5-fluorophenyl)-3,4-dihydro-...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCOc2cc(ccc12)-c1cc(F)ccc1Cl
Show InChI InChI=1S/C22H18ClFN2O3/c23-19-4-2-15(24)10-18(19)13-1-3-16-14(6-8-29-21(16)9-13)11-26-20-12-25-7-5-17(20)22(27)28/h1-5,7,9-10,12,14,26H,6,8,11H2,(H,27,28)/t14-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293707
PNG
(3-({[7-(thiophen-2-ylsulfanyl)-3,4-dihydro-2H-1-be...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(Sc3cccs3)ccc12
Show InChI InChI=1S/C20H18N2O3S2/c23-20(24)16-5-7-21-12-17(16)22-11-13-6-8-25-18-10-14(3-4-15(13)18)27-19-2-1-9-26-19/h1-5,7,9-10,12-13,22H,6,8,11H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293712
PNG
(3-({[(4S)-7-[(4-fluorophenyl)sulfanyl]-3,4-dihydro...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(Sc3ccc(F)cc3)ccc12
Show InChI InChI=1S/C22H19FN2O3S/c23-15-1-3-16(4-2-15)29-17-5-6-18-14(8-10-28-21(18)11-17)12-25-20-13-24-9-7-19(20)22(26)27/h1-7,9,11,13-14,25H,8,10,12H2,(H,26,27)/t14-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293717
PNG
(3-{[(6-propoxy-1,2,3,4-tetrahydronaphthalen-1- | U...)
Show SMILES CCCOc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C20H24N2O3/c1-2-10-25-16-6-7-17-14(11-16)4-3-5-15(17)12-22-19-13-21-9-8-18(19)20(23)24/h6-9,11,13,15,22H,2-5,10,12H2,1H3,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293773
PNG
(3-({[(1R)-6-[(3-cyanophenyl)(methyl)amino]-1,2,3,4...)
Show SMILES CN(c1cccc(c1)C#N)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C25H24N4O2/c1-29(20-7-2-4-17(12-20)14-26)21-8-9-22-18(13-21)5-3-6-19(22)15-28-24-16-27-11-10-23(24)25(30)31/h2,4,7-13,16,19,28H,3,5-6,15H2,1H3,(H,30,31)/t19-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293789
PNG
(3-({[(4R)-7-[(2,3-dihydro-1H-inden-5-yl)(methyl)am...)
Show SMILES CN(Cc1ccc2CCCc2c1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C27H29N3O3/c1-30(17-18-5-6-19-3-2-4-20(19)13-18)22-7-8-23-21(10-12-33-26(23)14-22)15-29-25-16-28-11-9-24(25)27(31)32/h5-9,11,13-14,16,21,29H,2-4,10,12,15,17H2,1H3,(H,31,32)/t21-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293807
PNG
(3-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)amino...)
Show SMILES OC(=O)c1ccncc1NCC1NCCc2ccccc12
Show InChI InChI=1S/C16H17N3O2/c20-16(21)13-6-7-17-9-14(13)19-10-15-12-4-2-1-3-11(12)5-8-18-15/h1-4,6-7,9,15,18-19H,5,8,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293810
PNG
(3-({[(4R)-7-[(5-chloropyridin-2-yl)(methyl)amino]-...)
Show SMILES CN(c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1)c1ccc(Cl)cn1
Show InChI InChI=1S/C22H21ClN4O3/c1-27(21-5-2-15(23)12-26-21)16-3-4-17-14(7-9-30-20(17)10-16)11-25-19-13-24-8-6-18(19)22(28)29/h2-6,8,10,12-14,25H,7,9,11H2,1H3,(H,28,29)/t14-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293814
PNG
(3-({[(1R)-6-[methyl(5-methylpyrimidin-2-yl)amino]-...)
Show SMILES CN(c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1)c1ncc(C)cn1
Show InChI InChI=1S/C23H25N5O2/c1-15-11-26-23(27-12-15)28(2)18-6-7-19-16(10-18)4-3-5-17(19)13-25-21-14-24-9-8-20(21)22(29)30/h6-12,14,17,25H,3-5,13H2,1-2H3,(H,29,30)/t17-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293828
PNG
(3-({[(1R)-6-{methyl[4-(morpholin-4-yl)phenyl]amino...)
Show SMILES CN(c1ccc(cc1)N1CCOCC1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C28H32N4O3/c1-31(22-5-7-23(8-6-22)32-13-15-35-16-14-32)24-9-10-25-20(17-24)3-2-4-21(25)18-30-27-19-29-12-11-26(27)28(33)34/h5-12,17,19,21,30H,2-4,13-16,18H2,1H3,(H,33,34)/t21-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293830
PNG
(3-({[(1R)-6-[(2-methoxyphenyl)(methyl)amino]-1,2,3...)
Show SMILES COc1ccccc1N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C25H27N3O3/c1-28(23-8-3-4-9-24(23)31-2)19-10-11-20-17(14-19)6-5-7-18(20)15-27-22-16-26-13-12-21(22)25(29)30/h3-4,8-14,16,18,27H,5-7,15H2,1-2H3,(H,29,30)/t18-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293834
PNG
(3-({[(4R)-7-[(4-ethenylphenyl)(methyl)amino]-3,4-d...)
Show SMILES CN(c1ccc(C=C)cc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C25H25N3O3/c1-3-17-4-6-19(7-5-17)28(2)20-8-9-21-18(11-13-31-24(21)14-20)15-27-23-16-26-12-10-22(23)25(29)30/h3-10,12,14,16,18,27H,1,11,13,15H2,2H3,(H,29,30)/t18-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293840
PNG
(3-({[(4R)-7-{methyl[4-(trifluoromethoxy)phenyl]ami...)
Show SMILES CN(c1ccc(OC(F)(F)F)cc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C24H22F3N3O4/c1-30(16-2-5-18(6-3-16)34-24(25,26)27)17-4-7-19-15(9-11-33-22(19)12-17)13-29-21-14-28-10-8-20(21)23(31)32/h2-8,10,12,14-15,29H,9,11,13H2,1H3,(H,31,32)/t15-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293846
PNG
(3-({[(1R)-6-{methyl[4-(1H-pyrazol-1-yl)phenyl]amin...)
Show SMILES CN(c1ccc(cc1)-n1cccn1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C27H27N5O2/c1-31(21-6-8-22(9-7-21)32-15-3-13-30-32)23-10-11-24-19(16-23)4-2-5-20(24)17-29-26-18-28-14-12-25(26)27(33)34/h3,6-16,18,20,29H,2,4-5,17H2,1H3,(H,33,34)/t20-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293849
PNG
(3-({[(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Show SMILES CN(c1ccccc1)c1ccc2[C@H](CNc3nnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C23H24N4O2/c1-27(18-8-3-2-4-9-18)19-10-11-20-16(14-19)6-5-7-17(20)15-24-22-21(23(28)29)12-13-25-26-22/h2-4,8-14,17H,5-7,15H2,1H3,(H,24,26)(H,28,29)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293852
PNG
(3-({[(4R)-7-{[4-(1H-imidazol-1-yl)phenyl](methyl)a...)
Show SMILES CN(c1ccc(cc1)-n1ccnc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C26H25N5O3/c1-30(19-2-4-20(5-3-19)31-12-11-28-17-31)21-6-7-22-18(9-13-34-25(22)14-21)15-29-24-16-27-10-8-23(24)26(32)33/h2-8,10-12,14,16-18,29H,9,13,15H2,1H3,(H,32,33)/t18-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293870
PNG
(3-({[(4R)-7-[methyl(4-propoxyphenyl)amino]-3,4-dih...)
Show SMILES CCCOc1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C26H29N3O4/c1-3-13-32-21-7-4-19(5-8-21)29(2)20-6-9-22-18(11-14-33-25(22)15-20)16-28-24-17-27-12-10-23(24)26(30)31/h4-10,12,15,17-18,28H,3,11,13-14,16H2,1-2H3,(H,30,31)/t18-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293873
PNG
(3-({[(4R)-7-{[4-(cyclopropylmethyl)phenyl](methyl)...)
Show SMILES CN(c1ccc(CC2CC2)cc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C27H29N3O3/c1-30(21-6-4-19(5-7-21)14-18-2-3-18)22-8-9-23-20(11-13-33-26(23)15-22)16-29-25-17-28-12-10-24(25)27(31)32/h4-10,12,15,17-18,20,29H,2-3,11,13-14,16H2,1H3,(H,31,32)/t20-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293661
PNG
(3-({[6-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydrona...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(ccc12)N1CCCC1=O
Show InChI InChI=1S/C21H23N3O3/c25-20-5-2-10-24(20)16-6-7-17-14(11-16)3-1-4-15(17)12-23-19-13-22-9-8-18(19)21(26)27/h6-9,11,13,15,23H,1-5,10,12H2,(H,26,27)
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293692
PNG
(3-({[(4R)-7-(thiophen-3-yl)-3,4-dihydro-2H-1-benzo...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCOc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C20H18N2O3S/c23-20(24)17-3-6-21-11-18(17)22-10-14-4-7-25-19-9-13(1-2-16(14)19)15-5-8-26-12-15/h1-3,5-6,8-9,11-12,14,22H,4,7,10H2,(H,23,24)/t14-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293693
PNG
(3-({[(4R)-7-cyclohexyl-3,4-dihydro-2H-1-benzopyran...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)C1CCCCC1
Show InChI InChI=1S/C22H26N2O3/c25-22(26)19-8-10-23-14-20(19)24-13-17-9-11-27-21-12-16(6-7-18(17)21)15-4-2-1-3-5-15/h6-8,10,12,14-15,17,24H,1-5,9,11,13H2,(H,25,26)
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293710
PNG
(3-({[(4S)-7-[(3-fluorophenyl)sulfanyl]-3,4-dihydro...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(Sc3cccc(F)c3)ccc12
Show InChI InChI=1S/C22H19FN2O3S/c23-15-2-1-3-16(10-15)29-17-4-5-18-14(7-9-28-21(18)11-17)12-25-20-13-24-8-6-19(20)22(26)27/h1-6,8,10-11,13-14,25H,7,9,12H2,(H,26,27)/t14-/m1/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293719
PNG
(3-({[(1R)-6-(difluoromethoxy)-1,2,3,4-tetrahydrona...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCCc2cc(OC(F)F)ccc12
Show InChI InChI=1S/C18H18F2N2O3/c19-18(20)25-13-4-5-14-11(8-13)2-1-3-12(14)9-22-16-10-21-7-6-15(16)17(23)24/h4-8,10,12,18,22H,1-3,9H2,(H,23,24)/t12-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293725
PNG
(3-({[(1R)-6-(2-chlorophenoxy)-1,2,3,4-tetrahydrona...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCCc2cc(Oc3ccccc3Cl)ccc12
Show InChI InChI=1S/C23H21ClN2O3/c24-20-6-1-2-7-22(20)29-17-8-9-18-15(12-17)4-3-5-16(18)13-26-21-14-25-11-10-19(21)23(27)28/h1-2,6-12,14,16,26H,3-5,13H2,(H,27,28)/t16-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293731
PNG
(3-({[(1R)-6-[(2-fluorophenyl)sulfanyl]-1,2,3,4- | ...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCCc2cc(Sc3ccccc3F)ccc12
Show InChI InChI=1S/C23H21FN2O2S/c24-20-6-1-2-7-22(20)29-17-8-9-18-15(12-17)4-3-5-16(18)13-26-21-14-25-11-10-19(21)23(27)28/h1-2,6-12,14,16,26H,3-5,13H2,(H,27,28)/t16-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293740
PNG
(3-({[(1R)-6-(benzenesulfonyl)-1,2,3,4-tetrahydrona...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCCc2cc(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H22N2O4S/c26-23(27)21-11-12-24-15-22(21)25-14-17-6-4-5-16-13-19(9-10-20(16)17)30(28,29)18-7-2-1-3-8-18/h1-3,7-13,15,17,25H,4-6,14H2,(H,26,27)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293741
PNG
(3-({[(1S)-6-(4-methylbenzenesulfonyl)-1,2,3,4- | U...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C24H24N2O4S/c1-16-5-7-19(8-6-16)31(29,30)20-9-10-21-17(13-20)3-2-4-18(21)14-26-23-15-25-12-11-22(23)24(27)28/h5-13,15,18,26H,2-4,14H2,1H3,(H,27,28)/t18-/m1/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293746
PNG
(3-({[6-(oxan-4-yl)-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(ccc12)C1CCOCC1
Show InChI InChI=1S/C22H26N2O3/c25-22(26)20-6-9-23-14-21(20)24-13-18-3-1-2-17-12-16(4-5-19(17)18)15-7-10-27-11-8-15/h4-6,9,12,14-15,18,24H,1-3,7-8,10-11,13H2,(H,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293753
PNG
(3-{[(6,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES COc1cc2CCCC(CNc3cnccc3C(O)=O)c2c(OC)c1
Show InChI InChI=1S/C19H22N2O4/c1-24-14-8-12-4-3-5-13(18(12)17(9-14)25-2)10-21-16-11-20-7-6-15(16)19(22)23/h6-9,11,13,21H,3-5,10H2,1-2H3,(H,22,23)
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UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293757
PNG
(3-({[(1R)-6-methoxy-5-methyl-1,2,3,4-tetrahydronap...)
Show SMILES COc1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1C
Show InChI InChI=1S/C19H22N2O3/c1-12-14-5-3-4-13(15(14)6-7-18(12)24-2)10-21-17-11-20-9-8-16(17)19(22)23/h6-9,11,13,21H,3-5,10H2,1-2H3,(H,22,23)/t13-/m0/s1
PDB

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UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293764
PNG
(3-({[(1R)-6-(pyrrolidin-1-yl)-1,2,3,4-tetrahydrona...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCCc2cc(ccc12)N1CCCC1
Show InChI InChI=1S/C21H25N3O2/c25-21(26)19-8-9-22-14-20(19)23-13-16-5-3-4-15-12-17(6-7-18(15)16)24-10-1-2-11-24/h6-9,12,14,16,23H,1-5,10-11,13H2,(H,25,26)/t16-/m0/s1
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UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293778
PNG
(3-({[(1R)-6-[(cyclopropylmethyl)(methyl)amino]-1,2...)
Show SMILES CN(CC1CC1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C22H27N3O2/c1-25(14-15-5-6-15)18-7-8-19-16(11-18)3-2-4-17(19)12-24-21-13-23-10-9-20(21)22(26)27/h7-11,13,15,17,24H,2-6,12,14H2,1H3,(H,26,27)/t17-/m0/s1
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UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293782
PNG
(3-({[(4R)-7-(2-cyanophenyl)-3,4-dihydro-2H-1-benzo...)
Show SMILES OC(=O)c1ccncc1NC[C@@H]1CCOc2cc(ccc12)-c1ccccc1C#N
Show InChI InChI=1S/C23H19N3O3/c24-12-16-3-1-2-4-18(16)15-5-6-19-17(8-10-29-22(19)11-15)13-26-21-14-25-9-7-20(21)23(27)28/h1-7,9,11,14,17,26H,8,10,13H2,(H,27,28)/t17-/m0/s1
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UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293799
PNG
(3-({[(4R)-7-[(1-benzofuran-6-yl)(methyl)amino]-3,4...)
Show SMILES CN(c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1)c1ccc2ccoc2c1
Show InChI InChI=1S/C25H23N3O4/c1-28(18-3-2-16-7-10-31-23(16)12-18)19-4-5-20-17(8-11-32-24(20)13-19)14-27-22-15-26-9-6-21(22)25(29)30/h2-7,9-10,12-13,15,17,27H,8,11,14H2,1H3,(H,29,30)/t17-/m0/s1
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US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293816
PNG
(3-({[(1R)-6-{[4-(hydroxymethyl)phenyl](methyl)amin...)
Show SMILES CN(c1ccc(CO)cc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C25H27N3O3/c1-28(20-7-5-17(16-29)6-8-20)21-9-10-22-18(13-21)3-2-4-19(22)14-27-24-15-26-12-11-23(24)25(30)31/h5-13,15,19,27,29H,2-4,14,16H2,1H3,(H,30,31)/t19-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM293839
PNG
(3-({[(1R)-6-{methyl[4-(trifluoromethoxy)phenyl]ami...)
Show SMILES CN(c1ccc(OC(F)(F)F)cc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C25H24F3N3O3/c1-31(18-5-8-20(9-6-18)34-25(26,27)28)19-7-10-21-16(13-19)3-2-4-17(21)14-30-23-15-29-12-11-22(23)24(32)33/h5-13,15,17,30H,2-4,14H2,1H3,(H,32,33)/t17-/m0/s1
PDB

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UniChem
US Patent
n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%