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Patent code US10106553

Compile Data Set for Download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293982
PNG
((2S)-5-(2-(4-((3-(2-Methyl-4- (methylsulfonyl)phen...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)S(C)(=O)=O)c3c2)cc1
Show InChI InChI=1S/C29H26N4O3S2/c1-4-5-22(16-29-30-32-33-31-29)21-7-9-23(10-8-21)36-17-20-6-13-28-26(15-20)27(18-37-28)25-12-11-24(14-19(25)2)38(3,34)35/h6-15,18,22H,16-17H2,1-3H3,(H,30,31,32,33)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293983
PNG
((2S)-5-(2-(4-((3-(5-(2- Methoxyethoxy)-2- methylph...)
Show SMILES COCCOc1ccc(C)c(c1)-c1csc2ccc(COc3ccc(cc3)[C@H](Cc3nnn[nH]3)C#CC)cc12
Show InChI InChI=1S/C31H30N4O3S/c1-4-5-24(17-31-32-34-35-33-31)23-8-11-25(12-9-23)38-19-22-7-13-30-28(16-22)29(20-39-30)27-18-26(10-6-21(27)2)37-15-14-36-3/h6-13,16,18,20,24H,14-15,17,19H2,1-3H3,(H,32,33,34,35)/t24-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293985
PNG
((2S)-4-(4-(5-((4-(1-(1H- Tetrazol-5-yl)pent-3-yn-2...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)C4CCS(=O)(=O)CC4)c3c2)cc1
Show InChI InChI=1S/C33H32N4O3S2/c1-3-4-26(19-33-34-36-37-35-33)24-6-9-28(10-7-24)40-20-23-5-12-32-30(18-23)31(21-41-32)29-11-8-27(17-22(29)2)25-13-15-42(38,39)16-14-25/h5-12,17-18,21,25-26H,13-16,19-20H2,1-2H3,(H,34,35,36,37)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293999
PNG
(3-(4-(5-((4-((2S)-1-(1H- Tetrazol-5-yl)pent-3-yn-2...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1
Show InChI InChI=1S/C31H30N4O4S/c1-3-4-23(15-31-32-34-35-33-31)22-6-8-25(9-7-22)38-17-21-5-12-30-28(14-21)29(19-40-30)27-11-10-26(13-20(27)2)39-18-24(37)16-36/h5-14,19,23-24,36-37H,15-18H2,1-2H3,(H,32,33,34,35)/t23-,24?/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294001
PNG
((2S)-3-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- y...)
Show SMILES COCCOc1cnc(C)c(c1)-c1csc2ccc(COc3ccc(cc3)[C@H](Cc3nnn[nH]3)C#CC)cc12
Show InChI InChI=1S/C30H29N5O3S/c1-4-5-23(15-30-32-34-35-33-30)22-7-9-24(10-8-22)38-18-21-6-11-29-27(14-21)28(19-39-29)26-16-25(17-31-20(26)2)37-13-12-36-3/h6-11,14,16-17,19,23H,12-13,15,18H2,1-3H3,(H,32,33,34,35)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294023
PNG
((2S)-5-(2-(4-((3- Cyclohexylbenzo[b]thiophen-5- yl...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CCCCC4)c3c2)cc1
Show InChI InChI=1S/C27H28N4OS/c1-2-6-22(16-27-28-30-31-29-27)20-10-12-23(13-11-20)32-17-19-9-14-26-24(15-19)25(18-33-26)21-7-4-3-5-8-21/h9-15,18,21-22H,3-5,7-8,16-17H2,1H3,(H,28,29,30,31)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294024
PNG
((2S)-5-(2-(4-((3- Cyclopentylbenzo[b]thiophen- 5-y...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CCCC4)c3c2)cc1
Show InChI InChI=1S/C26H26N4OS/c1-2-5-21(15-26-27-29-30-28-26)19-9-11-22(12-10-19)31-16-18-8-13-25-23(14-18)24(17-32-25)20-6-3-4-7-20/h8-14,17,20-21H,3-4,6-7,15-16H2,1H3,(H,27,28,29,30)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294025
PNG
((2S)-5-(2-(4-((3- Cyclopropylbenzo[b]thiophen- 5-y...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CC4)c3c2)cc1
Show InChI InChI=1S/C24H22N4OS/c1-2-3-19(13-24-25-27-28-26-24)17-7-9-20(10-8-17)29-14-16-4-11-23-21(12-16)22(15-30-23)18-5-6-18/h4,7-12,15,18-19H,5-6,13-14H2,1H3,(H,25,26,27,28)/t19-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293969
PNG
((2S)-5-(2-(4-((3-(2- Methylphenyl)benzo[b]thiophen...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H24N4OS/c1-3-6-22(16-28-29-31-32-30-28)21-10-12-23(13-11-21)33-17-20-9-14-27-25(15-20)26(18-34-27)24-8-5-4-7-19(24)2/h4-5,7-15,18,22H,16-17H2,1-2H3,(H,29,30,31,32)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293973
PNG
((2S)-4-(5-((4-(1-(1H-tetrazol-5- yl)pent-3-yn-2- y...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cc(Cl)ncc4C)c3c2)cc1
Show InChI InChI=1S/C27H22ClN5OS/c1-3-4-20(12-27-30-32-33-31-27)19-6-8-21(9-7-19)34-15-18-5-10-25-23(11-18)24(16-35-25)22-13-26(28)29-14-17(22)2/h5-11,13-14,16,20H,12,15H2,1-2H3,(H,30,31,32,33)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293976
PNG
((2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylph...)
Show SMILES COCCOc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C31H30N4O3S/c1-4-5-24(18-31-32-34-35-33-31)23-7-9-25(10-8-23)38-19-22-6-13-30-28(17-22)29(20-39-30)27-12-11-26(16-21(27)2)37-15-14-36-3/h6-13,16-17,20,24H,14-15,18-19H2,1-3H3,(H,32,33,34,35)/t24-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293978
PNG
((2S)-5-(2-(4-((3-(3-(2- Methoxyethoxy)-2- methylph...)
Show SMILES COCCOc1cccc(-c2csc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c1C
Show InChI InChI=1S/C31H30N4O3S/c1-4-6-24(18-31-32-34-35-33-31)23-10-12-25(13-11-23)38-19-22-9-14-30-27(17-22)28(20-39-30)26-7-5-8-29(21(26)2)37-16-15-36-3/h5,7-14,17,20,24H,15-16,18-19H2,1-3H3,(H,32,33,34,35)/t24-/m0/s1
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Janssen Pharmaceutica NV

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Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293993
PNG
((2S)-5-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- y...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cncnc4C)c3c2)cc1
Show InChI InChI=1S/C26H22N6OS/c1-3-4-20(12-26-29-31-32-30-26)19-6-8-21(9-7-19)33-14-18-5-10-25-22(11-18)24(15-34-25)23-13-27-16-28-17(23)2/h5-11,13,15-16,20H,12,14H2,1-2H3,(H,29,30,31,32)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293997
PNG
((2S)-N-(3-(5-((4-(1-(1H- tetrazol-5-yl)pent-3-yn-2...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cc(NS(C)(=O)=O)ccc4C)c3c2)cc1
Show InChI InChI=1S/C29H27N5O3S2/c1-4-5-22(15-29-30-33-34-31-29)21-8-11-24(12-9-21)37-17-20-7-13-28-26(14-20)27(18-38-28)25-16-23(10-6-19(25)2)32-39(3,35)36/h6-14,16,18,22,32H,15,17H2,1-3H3,(H,30,31,33,34)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294016
PNG
(1-(5-((4-((2S)-1-(1H-Tetrazol-5- yl)pent-3-yn-2- y...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(N4CCCCC4C)c3c2)cc1
Show InChI InChI=1S/C27H29N5OS/c1-3-6-22(16-27-28-30-31-29-27)21-9-11-23(12-10-21)33-17-20-8-13-26-24(15-20)25(18-34-26)32-14-5-4-7-19(32)2/h8-13,15,18-19,22H,4-5,7,14,16-17H2,1-2H3,(H,28,29,30,31)/t19?,22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294017
PNG
((2S)-5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)p...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cnc3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C27H23N5OS/c1-3-6-21(14-26-29-31-32-30-26)20-9-11-22(12-10-20)33-16-19-13-24-25(17-34-27(24)28-15-19)23-8-5-4-7-18(23)2/h4-5,7-13,15,17,21H,14,16H2,1-2H3,(H,29,30,31,32)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294021
PNG
((2S)-5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)p...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3n2)cc1
Show InChI InChI=1S/C27H23N5OS/c1-3-6-20(15-26-29-31-32-30-26)19-9-12-22(13-10-19)33-16-21-11-14-25-27(28-21)24(17-34-25)23-8-5-4-7-18(23)2/h4-5,7-14,17,20H,15-16H2,1-2H3,(H,29,30,31,32)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294035
PNG
((2S)-5-(2-(4-((7-Chloro-3-(2- methylphenyl)benzo[b...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H23ClN4OS/c1-3-6-21(15-27-30-32-33-31-27)20-9-11-22(12-10-20)34-16-19-13-24-25(17-35-28(24)26(29)14-19)23-8-5-4-7-18(23)2/h4-5,7-14,17,21H,15-16H2,1-2H3,(H,30,31,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294036
PNG
((2S)-5-(2-(4-((7-Chloro-3-(4- methoxy-2- methylphe...)
Show SMILES COc1ccc(-c2csc3c(Cl)cc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C29H25ClN4O2S/c1-4-5-21(15-28-31-33-34-32-28)20-6-8-22(9-7-20)36-16-19-13-25-26(17-37-29(25)27(30)14-19)24-11-10-23(35-3)12-18(24)2/h6-14,17,21H,15-16H2,1-3H3,(H,31,32,33,34)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293979
PNG
((2S)-3-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- y...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccnc4C)c3c2)cc1
Show InChI InChI=1S/C27H23N5OS/c1-3-5-21(15-27-29-31-32-30-27)20-8-10-22(11-9-20)33-16-19-7-12-26-24(14-19)25(17-34-26)23-6-4-13-28-18(23)2/h4,6-14,17,21H,15-16H2,1-2H3,(H,29,30,31,32)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293986
PNG
(4-(4-(5-((4-((2S)-1-(1H- Tetrazol-5-yl)pent-3-yn-2...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccc(OC5CCS(=O)(=O)CC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C34H34N4O4S2/c1-4-5-26(20-33-35-37-38-36-33)25-7-9-27(10-8-25)41-21-24-6-13-32-31(19-24)34(23(3)43-32)30-12-11-29(18-22(30)2)42-28-14-16-44(39,40)17-15-28/h6-13,18-19,26,28H,14-17,20-21H2,1-3H3,(H,35,36,37,38)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294005
PNG
((2S)-5-(2-(4-((3-Cyclopropyl-2- (trifluoromethyl)b...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(c(C4CC4)c3c2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H21F3N4OS/c1-2-3-18(13-22-29-31-32-30-22)16-7-9-19(10-8-16)33-14-15-4-11-21-20(12-15)23(17-5-6-17)24(34-21)25(26,27)28/h4,7-12,17-18H,5-6,13-14H2,1H3,(H,29,30,31,32)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294008
PNG
((2S)-5-(1-(1H-Tetrazol-5- yl)pent-3-yn-2-yl)-2-((3...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)nc1
Show InChI InChI=1S/C27H23N5OS/c1-3-6-20(14-26-29-31-32-30-26)21-10-12-27(28-15-21)33-16-19-9-11-25-23(13-19)24(17-34-25)22-8-5-4-7-18(22)2/h4-5,7-13,15,17,20H,14,16H2,1-2H3,(H,29,30,31,32)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294011
PNG
((2S)-4-(4-(5-(((5-(1-(1H- Tetrazol-5-yl)pent-3-yn-...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)nc1
Show InChI InChI=1S/C32H33N5O3S/c1-5-6-23(17-30-34-36-37-35-30)24-8-12-31(33-18-24)40-19-22-7-11-29-27(16-22)28(20-41-29)26-10-9-25(15-21(26)2)39-14-13-32(3,4)38/h7-12,15-16,18,20,23,38H,13-14,17,19H2,1-4H3,(H,34,35,36,37)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294015
PNG
(5-((2S)-2-(4-((3-(4-(2- Methoxyethoxy)-2- methylph...)
Show SMILES COCCOc1ccc(-c2c(sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C32H29F3N4O3S/c1-4-5-23(18-29-36-38-39-37-29)22-7-9-24(10-8-22)42-19-21-6-13-28-27(17-21)30(31(43-28)32(33,34)35)26-12-11-25(16-20(26)2)41-15-14-40-3/h6-13,16-17,23H,14-15,18-19H2,1-3H3,(H,36,37,38,39)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294018
PNG
((2S)-5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)p...)
Show SMILES COc1ccc(-c2csc3ncc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C28H25N5O2S/c1-4-5-21(14-27-30-32-33-31-27)20-6-8-22(9-7-20)35-16-19-13-25-26(17-36-28(25)29-15-19)24-11-10-23(34-3)12-18(24)2/h6-13,15,17,21H,14,16H2,1-3H3,(H,30,31,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294019
PNG
((2S)-5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)p...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc3c(csc3cn2)-c2ccccc2C)cc1
Show InChI InChI=1S/C27H23N5OS/c1-3-6-20(13-27-29-31-32-30-27)19-9-11-22(12-10-19)33-16-21-14-24-25(17-34-26(24)15-28-21)23-8-5-4-7-18(23)2/h4-5,7-12,14-15,17,20H,13,16H2,1-2H3,(H,29,30,31,32)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294020
PNG
((2S)-5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)p...)
Show SMILES COc1ccc(-c2csc3cnc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C28H25N5O2S/c1-4-5-20(13-28-30-32-33-31-28)19-6-8-22(9-7-19)35-16-21-14-25-26(17-36-27(25)15-29-21)24-11-10-23(34-3)12-18(24)2/h6-12,14-15,17,20H,13,16H2,1-3H3,(H,30,31,32,33)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294028
PNG
((2S)-5-(2-(4-(Benzo[b]thiophen- 5-ylmethoxy)phenyl...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sccc3c2)cc1
Show InChI InChI=1S/C21H18N4OS/c1-2-3-17(13-21-22-24-25-23-21)16-5-7-19(8-6-16)26-14-15-4-9-20-18(12-15)10-11-27-20/h4-12,17H,13-14H2,1H3,(H,22,23,24,25)/t17-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294032
PNG
((2S)-5-(2-(4-((3-Butyl-7- methylbenzo[b]thiophen-5...)
Show SMILES CCCCc1csc2c(C)cc(COc3ccc(cc3)[C@H](Cc3nnn[nH]3)C#CC)cc12
Show InChI InChI=1S/C26H28N4OS/c1-4-6-8-22-17-32-26-18(3)13-19(14-24(22)26)16-31-23-11-9-20(10-12-23)21(7-5-2)15-25-27-29-30-28-25/h9-14,17,21H,4,6,8,15-16H2,1-3H3,(H,27,28,29,30)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293971
PNG
(5-((2S)-2-(4-((2-Fluoro-3-(2- methylphenyl)benzo[b...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H23FN4OS/c1-3-6-21(16-26-30-32-33-31-26)20-10-12-22(13-11-20)34-17-19-9-14-25-24(15-19)27(28(29)35-25)23-8-5-4-7-18(23)2/h4-5,7-15,21H,16-17H2,1-2H3,(H,30,31,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293972
PNG
((2S)-5-(2-(4-((3-(2- Bromophenyl)benzo[b]thiophen-...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4Br)c3c2)cc1
Show InChI InChI=1S/C27H21BrN4OS/c1-2-5-20(15-27-29-31-32-30-27)19-9-11-21(12-10-19)33-16-18-8-13-26-23(14-18)24(17-34-26)22-6-3-4-7-25(22)28/h3-4,6-14,17,20H,15-16H2,1H3,(H,29,30,31,32)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293974
PNG
((2S)-4-((4-(5-((4-(1-(1H- Tetrazol-5-yl)pent-3-yn-...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccc(OCC5(O)CCS(=O)(=O)CC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C34H33ClN4O5S2/c1-3-4-25(19-31-36-38-39-37-31)24-6-8-26(9-7-24)43-20-23-5-12-30-29(18-23)32(33(35)45-30)28-11-10-27(17-22(28)2)44-21-34(40)13-15-46(41,42)16-14-34/h5-12,17-18,25,40H,13-16,19-21H2,1-2H3,(H,36,37,38,39)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293988
PNG
((2S)-5-(2-(4-((3-(2,6- Dimethylphenyl)benzo[b] thi...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4c(C)cccc4C)c3c2)cc1
Show InChI InChI=1S/C29H26N4OS/c1-4-6-23(16-28-30-32-33-31-28)22-10-12-24(13-11-22)34-17-21-9-14-27-25(15-21)26(18-35-27)29-19(2)7-5-8-20(29)3/h5,7-15,18,23H,16-17H2,1-3H3,(H,30,31,32,33)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294006
PNG
(5-((2S)-2-(4-((2-Cyano-3-(2- methylphenyl)benzo[b]...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C#N)c(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C29H23N5OS/c1-3-6-22(16-28-31-33-34-32-28)21-10-12-23(13-11-21)35-18-20-9-14-26-25(15-20)29(27(17-30)36-26)24-8-5-4-7-19(24)2/h4-5,7-15,22H,16,18H2,1-2H3,(H,31,32,33,34)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294009
PNG
((2S)-5-(1-(1H-Tetrazol-5- yl)pent-3-yn-2-yl)-2-((3...)
Show SMILES COCCOc1ccc(-c2csc3ccc(COc4ccc(cn4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C30H29N5O3S/c1-4-5-22(16-29-32-34-35-33-29)23-7-11-30(31-17-23)38-18-21-6-10-28-26(15-21)27(19-39-28)25-9-8-24(14-20(25)2)37-13-12-36-3/h6-11,14-15,17,19,22H,12-13,16,18H2,1-3H3,(H,32,33,34,35)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294026
PNG
((2S)-5-(2-(4-((3- Isopropylbenzo[b]thiophen-5- yl)...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C(C)C)c3c2)cc1
Show InChI InChI=1S/C24H24N4OS/c1-4-5-19(13-24-25-27-28-26-24)18-7-9-20(10-8-18)29-14-17-6-11-23-21(12-17)22(15-30-23)16(2)3/h6-12,15-16,19H,13-14H2,1-3H3,(H,25,26,27,28)/t19-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294031
PNG
((2S)-5-(2-(4-((7-Methyl-3-(2- methylphenyl)benzo[b...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(C)c3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C29H26N4OS/c1-4-7-23(16-28-30-32-33-31-28)22-10-12-24(13-11-22)34-17-21-14-20(3)29-26(15-21)27(18-35-29)25-9-6-5-8-19(25)2/h5-6,8-15,18,23H,16-17H2,1-3H3,(H,30,31,32,33)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294034
PNG
((2S)-5-(2-(4-((3-Cyclohexyl-7- methylbenzo[b]thiop...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(C)c3scc(C4CCCCC4)c3c2)cc1
Show InChI InChI=1S/C28H30N4OS/c1-3-7-23(16-27-29-31-32-30-27)21-10-12-24(13-11-21)33-17-20-14-19(2)28-25(15-20)26(18-34-28)22-8-5-4-6-9-22/h10-15,18,22-23H,4-6,8-9,16-17H2,1-2H3,(H,29,30,31,32)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294037
PNG
((2S)-5-(2-(4-((7-Fluoro-3-(2- methylphenyl)benzo[b...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H23FN4OS/c1-3-6-21(15-27-30-32-33-31-27)20-9-11-22(12-10-20)34-16-19-13-24-25(17-35-28(24)26(29)14-19)23-8-5-4-7-18(23)2/h4-5,7-14,17,21H,15-16H2,1-2H3,(H,30,31,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293987
PNG
(5-((2S)-2-(4-((2-Methyl-3-(2- methylphenyl)benzo[b...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C29H26N4OS/c1-4-7-23(17-28-30-32-33-31-28)22-11-13-24(14-12-22)34-18-21-10-15-27-26(16-21)29(20(3)35-27)25-9-6-5-8-19(25)2/h5-6,8-16,23H,17-18H2,1-3H3,(H,30,31,32,33)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293991
PNG
((2S)-5-(2-(4-((3-(1-Methyl-1H- 1,2,4-triazol-5- yl...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ncnn4C)c3c2)cc1
Show InChI InChI=1S/C24H21N7OS/c1-3-4-18(12-23-27-29-30-28-23)17-6-8-19(9-7-17)32-13-16-5-10-22-20(11-16)21(14-33-22)24-25-15-26-31(24)2/h5-11,14-15,18H,12-13H2,1-2H3,(H,27,28,29,30)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293996
PNG
((2S)-1-(4-(5-((4-(1-(1H-tetrazol- 5-yl)pent-3-yn-2...)
Show SMILES CCC(=O)N1CCc2c1cccc2-c1csc2ccc(COc3ccc(cc3)[C@H](Cc3nnn[nH]3)C#CC)cc12
Show InChI InChI=1S/C32H29N5O2S/c1-3-6-23(18-31-33-35-36-34-31)22-10-12-24(13-11-22)39-19-21-9-14-30-27(17-21)28(20-40-30)25-7-5-8-29-26(25)15-16-37(29)32(38)4-2/h5,7-14,17,20,23H,4,15-16,18-19H2,1-2H3,(H,33,34,35,36)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294027
PNG
((2S)-5-(2-(4-((3- Propylbenzo[b]thiophen-5- yl)met...)
Show SMILES CCCc1csc2ccc(COc3ccc(cc3)[C@H](Cc3nnn[nH]3)C#CC)cc12
Show InChI InChI=1S/C24H24N4OS/c1-3-5-19(14-24-25-27-28-26-24)18-8-10-21(11-9-18)29-15-17-7-12-23-22(13-17)20(6-4-2)16-30-23/h7-13,16,19H,4,6,14-15H2,1-2H3,(H,25,26,27,28)/t19-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294030
PNG
((2S)-5-(2-(4-((3-(2- Methylphenyl)benzo[b]thiophen...)
Show SMILES CC#C[C@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H24N4OS/c1-3-6-22(16-28-29-31-32-30-28)21-10-12-23(13-11-21)33-17-20-9-14-27-25(15-20)26(18-34-27)24-8-5-4-7-19(24)2/h4-5,7-15,18,22H,16-17H2,1-2H3,(H,29,30,31,32)/t22-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293977
PNG
((2S)-5-(2-(4-((3-(2-Methyl-4- ((tetrahydro-2H-pyra...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OC5CCOCC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32N4O3S/c1-3-4-25(19-33-34-36-37-35-33)24-6-8-26(9-7-24)39-20-23-5-12-32-30(18-23)31(21-41-32)29-11-10-28(17-22(29)2)40-27-13-15-38-16-14-27/h5-12,17-18,21,25,27H,13-16,19-20H2,1-2H3,(H,34,35,36,37)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293989
PNG
((2S)-5-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- y...)
Show SMILES COCCOc1cc(C)c(cn1)-c1csc2ccc(COc3ccc(cc3)[C@H](Cc3nnn[nH]3)C#CC)cc12
Show InChI InChI=1S/C30H29N5O3S/c1-4-5-23(16-29-32-34-35-33-29)22-7-9-24(10-8-22)38-18-21-6-11-28-25(15-21)27(19-39-28)26-17-31-30(14-20(26)2)37-13-12-36-3/h6-11,14-15,17,19,23H,12-13,16,18H2,1-3H3,(H,32,33,34,35)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293992
PNG
((2S)-2-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- y...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4nccnc4C)c3c2)cc1
Show InChI InChI=1S/C26H22N6OS/c1-3-4-20(14-25-29-31-32-30-25)19-6-8-21(9-7-19)33-15-18-5-10-24-22(13-18)23(16-34-24)26-17(2)27-11-12-28-26/h5-13,16,20H,14-15H2,1-2H3,(H,29,30,31,32)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293994
PNG
((2S)-2-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2-yl...)
Show SMILES COCCOc1cnc(-c2csc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C30H29N5O3S/c1-4-5-23(16-29-32-34-35-33-29)22-7-9-24(10-8-22)38-18-21-6-11-28-26(15-21)27(19-39-28)30-20(2)14-25(17-31-30)37-13-12-36-3/h6-11,14-15,17,19,23H,12-13,16,18H2,1-3H3,(H,32,33,34,35)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293995
PNG
((2S)-5-(2-(4-((3-(2,3- Dihydrobenzo[b][1,4]dioxin-...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccc5OCCOc45)c3c2)cc1
Show InChI InChI=1S/C29H24N4O3S/c1-2-4-21(16-28-30-32-33-31-28)20-8-10-22(11-9-20)36-17-19-7-12-27-24(15-19)25(18-37-27)23-5-3-6-26-29(23)35-14-13-34-26/h3,5-12,15,18,21H,13-14,16-17H2,1H3,(H,30,31,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293998
PNG
((2S)-5-(2-(4-((3-(2,2- dimethylchroman-5- yl)benzo...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccc5OC(C)(C)CCc45)c3c2)cc1
Show InChI InChI=1S/C32H30N4O2S/c1-4-6-23(18-31-33-35-36-34-31)22-10-12-24(13-11-22)37-19-21-9-14-30-27(17-21)28(20-39-30)25-7-5-8-29-26(25)15-16-32(2,3)38-29/h5,7-14,17,20,23H,15-16,18-19H2,1-3H3,(H,33,34,35,36)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294002
PNG
(5-((2S)-2-(4-((2-Bromo-3-(2- methylphenyl)benzo[b]...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Br)c(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H23BrN4OS/c1-3-6-21(16-26-30-32-33-31-26)20-10-12-22(13-11-20)34-17-19-9-14-25-24(15-19)27(28(29)35-25)23-8-5-4-7-18(23)2/h4-5,7-15,21H,16-17H2,1-2H3,(H,30,31,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294013
PNG
((2S)-5-(2-(4-((2-Chloro-3-(4-(2- methoxyethoxy)-2-...)
Show SMILES COCCOc1ccc(-c2c(Cl)sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C31H29ClN4O3S/c1-4-5-23(18-29-33-35-36-34-29)22-7-9-24(10-8-22)39-19-21-6-13-28-27(17-21)30(31(32)40-28)26-12-11-25(16-20(26)2)38-15-14-37-3/h6-13,16-17,23H,14-15,18-19H2,1-3H3,(H,33,34,35,36)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294033
PNG
((2S)-5-(2-(4-((3-Cyclopentyl-7- methylbenzo[b]thio...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(C)c3scc(C4CCCC4)c3c2)cc1
Show InChI InChI=1S/C27H28N4OS/c1-3-6-22(15-26-28-30-31-29-26)20-9-11-23(12-10-20)32-16-19-13-18(2)27-24(14-19)25(17-33-27)21-7-4-5-8-21/h9-14,17,21-22H,4-5,7-8,15-16H2,1-2H3,(H,28,29,30,31)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293970
PNG
(5-((2S)-2-(4-((2-Chloro-3-(2- methylphenyl)benzo[b...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H23ClN4OS/c1-3-6-21(16-26-30-32-33-31-26)20-10-12-22(13-11-20)34-17-19-9-14-25-24(15-19)27(28(29)35-25)23-8-5-4-7-18(23)2/h4-5,7-15,21H,16-17H2,1-2H3,(H,30,31,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293980
PNG
((2S)-3-((4-(5-((4-(1-(1H- Tetrazol-5-yl)pent-3-yn-...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32N4O4S2/c1-4-5-25(16-32-34-36-37-35-32)24-7-9-26(10-8-24)40-17-23-6-13-31-29(15-23)30(18-42-31)28-12-11-27(14-22(28)2)41-19-33(3)20-43(38,39)21-33/h6-15,18,25H,16-17,19-21H2,1-3H3,(H,34,35,36,37)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293990
PNG
((2S)-5-(2-(4-((3-(1-Methyl-1H- pyrazol-5-yl)benzo[...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccnn4C)c3c2)cc1
Show InChI InChI=1S/C25H22N6OS/c1-3-4-19(14-25-27-29-30-28-25)18-6-8-20(9-7-18)32-15-17-5-10-24-21(13-17)22(16-33-24)23-11-12-26-31(23)2/h5-13,16,19H,14-15H2,1-2H3,(H,27,28,29,30)/t19-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294000
PNG
((2S)-5-(2-(4-((3-(2- Chlorophenyl)benzo[b]thiophen...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4Cl)c3c2)cc1
Show InChI InChI=1S/C27H21ClN4OS/c1-2-5-20(15-27-29-31-32-30-27)19-9-11-21(12-10-19)33-16-18-8-13-26-23(14-18)24(17-34-26)22-6-3-4-7-25(22)28/h3-4,6-14,17,20H,15-16H2,1H3,(H,29,30,31,32)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294003
PNG
(5-((2S)-2-(4-((2-Iodo-3-(2- methylphenyl)benzo[b]t...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(I)c(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H23IN4OS/c1-3-6-21(16-26-30-32-33-31-26)20-10-12-22(13-11-20)34-17-19-9-14-25-24(15-19)27(28(29)35-25)23-8-5-4-7-18(23)2/h4-5,7-15,21H,16-17H2,1-2H3,(H,30,31,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294004
PNG
(5-((2S)-2-(4-((2- Trifluoromethyl-3-(2- methylphen...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(c(-c4ccccc4C)c3c2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H23F3N4OS/c1-3-6-21(16-26-33-35-36-34-26)20-10-12-22(13-11-20)37-17-19-9-14-25-24(15-19)27(28(38-25)29(30,31)32)23-8-5-4-7-18(23)2/h4-5,7-15,21H,16-17H2,1-2H3,(H,33,34,35,36)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294022
PNG
((2S)-5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)p...)
Show SMILES COc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)nc23)c(C)c1
Show InChI InChI=1S/C28H25N5O2S/c1-4-5-20(15-27-30-32-33-31-27)19-6-9-22(10-7-19)35-16-21-8-13-26-28(29-21)25(17-36-26)24-12-11-23(34-3)14-18(24)2/h6-14,17,20H,15-16H2,1-3H3,(H,30,31,32,33)/t20-/m0/s1
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n/an/an/an/a 180n/an/an/a25



Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294029
PNG
((2S)-5-(2-(4-((3-(2- Methylphenyl)benzo[b]thiophen...)
Show SMILES CC#CC(Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H24N4OS/c1-3-6-22(16-28-29-31-32-30-28)21-10-12-23(13-11-21)33-17-20-9-14-27-25(15-20)26(18-34-27)24-8-5-4-7-19(24)2/h4-5,7-15,18,22H,16-17H2,1-2H3,(H,29,30,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294038
PNG
((2S)-5-(2-(4-((7-Fluoro-3-(4- methoxy-2- methylphe...)
Show SMILES COc1ccc(-c2csc3c(F)cc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C29H25FN4O2S/c1-4-5-21(15-28-31-33-34-32-28)20-6-8-22(9-7-20)36-16-19-13-25-26(17-37-29(25)27(30)14-19)24-11-10-23(35-3)12-18(24)2/h6-14,17,21H,15-16H2,1-3H3,(H,31,32,33,34)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293975
PNG
((2S)-4-(4-(5-((4-(1-(1H- Tetrazol-5-yl)pent-3-yn-2...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H34N4O3S/c1-5-6-25(19-32-34-36-37-35-32)24-8-10-26(11-9-24)40-20-23-7-14-31-29(18-23)30(21-41-31)28-13-12-27(17-22(28)2)39-16-15-33(3,4)38/h7-14,17-18,21,25,38H,15-16,19-20H2,1-4H3,(H,34,35,36,37)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293981
PNG
((2S)-5-(2-(4-((3-(2- (Trifluoromethyl)phenyl)benzo...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C(F)(F)F)c3c2)cc1
Show InChI InChI=1S/C28H21F3N4OS/c1-2-5-20(15-27-32-34-35-33-27)19-9-11-21(12-10-19)36-16-18-8-13-26-23(14-18)24(17-37-26)22-6-3-4-7-25(22)28(29,30)31/h3-4,6-14,17,20H,15-16H2,1H3,(H,32,33,34,35)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM293984
PNG
((2S)-5-(2-(4-((3-(2-Methyl-4-(3- (methylsulfonyl)p...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1
Show InChI InChI=1S/C32H32N4O4S2/c1-4-6-25(19-32-33-35-36-34-32)24-8-10-26(11-9-24)40-20-23-7-14-31-29(18-23)30(21-41-31)28-13-12-27(17-22(28)2)39-15-5-16-42(3,37)38/h7-14,17-18,21,25H,5,15-16,19-20H2,1-3H3,(H,33,34,35,36)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294007
PNG
((2S)-5-(2-(4-((2- (Methylsulfonyl)-3-(2- methylphe...)
Show SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(c(-c4ccccc4C)c3c2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C29H26N4O3S2/c1-4-7-22(17-27-30-32-33-31-27)21-11-13-23(14-12-21)36-18-20-10-15-26-25(16-20)28(29(37-26)38(3,34)35)24-9-6-5-8-19(24)2/h5-6,8-16,22H,17-18H2,1-3H3,(H,30,31,32,33)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294010
PNG
((2S)-5-(1-(1H-Tetrazol-5- yl)pent-3-yn-2-yl)-2-((3...)
Show SMILES COCCOc1cccc(-c2csc3ccc(COc4ccc(cn4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c1C
Show InChI InChI=1S/C30H29N5O3S/c1-4-6-22(16-29-32-34-35-33-29)23-10-12-30(31-17-23)38-18-21-9-11-28-25(15-21)26(19-39-28)24-7-5-8-27(20(24)2)37-14-13-36-3/h5,7-12,15,17,19,22H,13-14,16,18H2,1-3H3,(H,32,33,34,35)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294012
PNG
((2S)-5-(2-(4-((2-Fluoro-3-(4-(2- methoxyethoxy)-2-...)
Show SMILES COCCOc1ccc(-c2c(F)sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C31H29FN4O3S/c1-4-5-23(18-29-33-35-36-34-29)22-7-9-24(10-8-22)39-19-21-6-13-28-27(17-21)30(31(32)40-28)26-12-11-25(16-20(26)2)38-15-14-37-3/h6-13,16-17,23H,14-15,18-19H2,1-3H3,(H,33,34,35,36)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM294014
PNG
((2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylph...)
Show SMILES COCCOc1ccc(-c2c(C)sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C32H32N4O3S/c1-5-6-25(19-31-33-35-36-34-31)24-8-10-26(11-9-24)39-20-23-7-14-30-29(18-23)32(22(3)40-30)28-13-12-27(17-21(28)2)38-16-15-37-4/h7-14,17-18,25H,15-16,19-20H2,1-4H3,(H,33,34,35,36)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10106553 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%