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Patent code US10112926

Compile Data Set for Download or QSAR

Found 1455 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295114
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(CO)CCOCC1
Show InChI InChI=1S/C23H28N4O5S/c1-15-3-4-18(33(29,30)26-13-23(14-28)5-7-31-8-6-23)11-19(15)17-10-20(22(24)25-12-17)21-9-16(2)27-32-21/h3-4,9-12,26,28H,5-8,13-14H2,1-2H3,(H2,24,25)
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n/an/a<3n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295065
PNG
(US10112926, Example 19 | trans 3-[6-Amino-5-(3-met...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](CO)CC1
Show InChI InChI=1S/C22H27N5O4S/c1-13-3-8-18(32(29,30)27-17-6-4-15(12-28)5-7-17)10-19(13)16-9-20(21(23)24-11-16)22-25-14(2)26-31-22/h3,8-11,15,17,27-28H,4-7,12H2,1-2H3,(H2,23,24)/t15-,17-
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n/an/a<3n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295115
PNG
(5-(5-((3-Methoxy-3-methylazetidin-1-yl)sulfonyl)-2...)
Show SMILES COC1(C)CN(C1)S(=O)(=O)c1ccc(C)c(c1)-c1cnc(N)c(c1)-c1nc(C)no1
Show InChI InChI=1S/C20H23N5O4S/c1-12-5-6-15(30(26,27)25-10-20(3,11-25)28-4)8-16(12)14-7-17(18(21)22-9-14)19-23-13(2)24-29-19/h5-9H,10-11H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295052
PNG
(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C22H25N5O4S/c1-12-3-4-17(32(29,30)27-15-7-22(8-15)9-16(28)10-22)6-18(12)14-5-19(20(23)24-11-14)21-25-13(2)26-31-21/h3-6,11,15-16,27-28H,7-10H2,1-2H3,(H2,23,24)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295116
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(CO)CCCCC1
Show InChI InChI=1S/C24H30N4O4S/c1-16-6-7-19(33(30,31)27-14-24(15-29)8-4-3-5-9-24)12-20(16)18-11-21(23(25)26-13-18)22-10-17(2)28-32-22/h6-7,10-13,27,29H,3-5,8-9,14-15H2,1-2H3,(H2,25,26)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295053
PNG
(US10112926, Example 8.1 | US10112926, Example 8.2)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC2(C[C@H](O)C2)C1
Show InChI InChI=1S/C22H25N5O4S/c1-12-3-4-17(32(29,30)27-15-7-22(8-15)9-16(28)10-22)6-18(12)14-5-19(20(23)24-11-14)21-25-13(2)26-31-21/h3-6,11,15-16,27-28H,7-10H2,1-2H3,(H2,23,24)/t15-,16-,22?
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295089
PNG
(US10112926, Example 21b)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NO[C@@H]1CCOC1
Show InChI InChI=1S/C20H22N4O5S/c1-12-3-4-16(30(25,26)24-28-15-5-6-27-11-15)9-17(12)14-8-18(20(21)22-10-14)19-7-13(2)23-29-19/h3-4,7-10,15,24H,5-6,11H2,1-2H3,(H2,21,22)/t15-/m1/s1
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295044
PNG
(US10112926, Example 5.2 | trans 3-(6-Amino-5- (5-m...)
Show SMILES Cc1cnc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H26N4O4S/c1-13-3-8-18(31(28,29)26-16-4-6-17(27)7-5-16)10-19(13)15-9-20(21(23)24-12-15)22-25-11-14(2)30-22/h3,8-12,16-17,26-27H,4-7H2,1-2H3,(H2,23,24)/t16-,17-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295239
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](CO)CC1
Show InChI InChI=1S/C23H28N4O4S/c1-14-3-8-19(32(29,30)27-18-6-4-16(13-28)5-7-18)10-20(14)17-9-21(23(24)26-11-17)22-12-25-15(2)31-22/h3,8-12,16,18,27-28H,4-7,13H2,1-2H3,(H2,24,26)/t16-,18-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295029
PNG
(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)
Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(CC(F)(F)F)c2)n1
Show InChI InChI=1S/C23H21F3N6O2S/c1-14-6-7-18(35(33,34)31-21-5-3-4-15(2)30-21)9-19(14)16-8-20(22(27)28-10-16)17-11-29-32(12-17)13-23(24,25)26/h3-12H,13H2,1-2H3,(H2,27,28)(H,30,31)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295205
PNG
(US10112926, Example 84 | cis-3-(6-Amino-5-(3-methy...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1S/C21H24N4O4S/c1-12-3-4-17(30(27,28)24-10-14-6-16(26)7-14)9-18(12)15-8-19(21(22)23-11-15)20-5-13(2)25-29-20/h3-5,8-9,11,14,16,24,26H,6-7,10H2,1-2H3,(H2,22,23)/t14-,16+
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295058
PNG
(US10112926, Example 12 | trans 3-[6-Amino-5-(3-met...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C21H25N5O4S/c1-12-3-8-17(31(28,29)26-15-4-6-16(27)7-5-15)10-18(12)14-9-19(20(22)23-11-14)21-24-13(2)25-30-21/h3,8-11,15-16,26-27H,4-7H2,1-2H3,(H2,22,23)/t15-,16-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295170
PNG
(US10112926, Example 55 | trans-3-(6-Amino-5-(3-met...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NO[C@H]1C[C@H](O)C1
Show InChI InChI=1S/C19H21N5O5S/c1-10-3-4-15(30(26,27)24-28-14-6-13(25)7-14)8-16(10)12-5-17(18(20)21-9-12)19-22-11(2)23-29-19/h3-5,8-9,13-14,24-25H,6-7H2,1-2H3,(H2,20,21)/t13-,14-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295034
PNG
(US10112926, Example 4.2 | trans 3-(6-Amino-5-(1- (...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnn(CC(F)(F)F)c1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C23H26F3N5O3S/c1-14-2-7-19(35(33,34)30-17-3-5-18(32)6-4-17)9-20(14)15-8-21(22(27)28-10-15)16-11-29-31(12-16)13-23(24,25)26/h2,7-12,17-18,30,32H,3-6,13H2,1H3,(H2,27,28)/t17-,18-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295105
PNG
(3-(6-Amino-5-(3-propyl isoxazol-5-yl)pyridin-3-yl)...)
Show SMILES CCCc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C22H28N4O4S/c1-5-6-16-10-20(30-26-16)19-9-15(12-24-21(19)23)18-11-17(8-7-14(18)2)31(28,29)25-13-22(3,4)27/h7-12,25,27H,5-6,13H2,1-4H3,(H2,23,24)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295182
PNG
(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(CO)COC1
Show InChI InChI=1S/C21H24N4O5S/c1-13-3-4-16(31(27,28)25-9-21(10-26)11-29-12-21)6-17(13)15-5-18(20(22)24-7-15)19-8-23-14(2)30-19/h3-8,25-26H,9-12H2,1-2H3,(H2,22,24)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295106
PNG
(US10112926, Example 35.2 | trans-3-(6-Amino-5-(3-(...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cc(no1)C(C)(C)C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O4S/c1-15-5-10-19(34(31,32)29-17-6-8-18(30)9-7-17)12-20(15)16-11-21(24(26)27-14-16)22-13-23(28-33-22)25(2,3)4/h5,10-14,17-18,29-30H,6-9H2,1-4H3,(H2,26,27)/t17-,18-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295218
PNG
(US10112926, Example 96 | trans-3-(6-amino-5-(3-met...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC[C@@H](O)C1
Show InChI InChI=1S/C21H24N4O4S/c1-12-3-6-17(30(27,28)25-15-4-5-16(26)9-15)10-18(12)14-8-19(21(22)23-11-14)20-7-13(2)24-29-20/h3,6-8,10-11,15-16,25-26H,4-5,9H2,1-2H3,(H2,22,23)/t15?,16-/m1/s1
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295245
PNG
(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Show SMILES Cc1nnc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S2/c1-12-5-6-15(30(27,28)23-8-7-20(3,4)26)10-16(12)14-9-17(18(21)22-11-14)19-25-24-13(2)29-19/h5-6,9-11,23,26H,7-8H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295099
PNG
(3-(6-Amino-5-(1-methyl-1H-pyrazol-4-yl)pyridin-3-y...)
Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C22H22N6O2S/c1-14-7-8-18(31(29,30)27-21-6-4-5-15(2)26-21)10-19(14)16-9-20(22(23)24-11-16)17-12-25-28(3)13-17/h4-13H,1-3H3,(H2,23,24)(H,26,27)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295063
PNG
(3-[6-Amino-5-(3-methyl-isoxazol-5-yl)-pyridin-3-yl...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(C)COC1
Show InChI InChI=1S/C21H24N4O4S/c1-13-4-5-16(30(26,27)24-10-21(3)11-28-12-21)8-17(13)15-7-18(20(22)23-9-15)19-6-14(2)25-29-19/h4-9,24H,10-12H2,1-3H3,(H2,22,23)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295032
PNG
(3-(6-Amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H26N4O3S2/c1-13-5-6-16(30(27,28)25-8-7-21(3,4)26)10-17(13)15-9-18(20(22)24-11-15)19-12-23-14(2)29-19/h5-6,9-12,25-26H,7-8H2,1-4H3,(H2,22,24)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295049
PNG
(3-(6-Amino-5-(5- methyl-1,3,4-oxa- diazol-2-yl)pyr...)
Show SMILES Cc1nnc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C20H25N5O4S/c1-12-5-6-15(30(27,28)23-8-7-20(3,4)26)10-16(12)14-9-17(18(21)22-11-14)19-25-24-13(2)29-19/h5-6,9-11,23,26H,7-8H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295042
PNG
(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C20H25N5O4S/c1-12-5-6-15(30(27,28)23-8-7-20(3,4)26)10-16(12)14-9-17(18(21)22-11-14)19-24-13(2)25-29-19/h5-6,9-11,23,26H,7-8H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295211
PNG
(3-(6-Amino-5-(5-methylthiazol-2-yl)pyridin-3-yl)-N...)
Show SMILES Cc1cnc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H24N4O3S2/c1-12-5-6-15(29(26,27)24-11-20(3,4)25)8-16(12)14-7-17(18(21)22-10-14)19-23-9-13(2)28-19/h5-10,24-25H,11H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295219
PNG
(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H26N4O3S2/c1-13-3-8-18(31(28,29)26-16-4-6-17(27)7-5-16)10-19(13)15-9-20(22(23)25-11-15)21-12-24-14(2)30-21/h3,8-12,16-17,26-27H,4-7H2,1-2H3,(H2,23,25)/t16-,17-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295057
PNG
(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NOCC(C)(C)O
Show InChI InChI=1S/C19H23N5O5S/c1-11-5-6-14(30(26,27)24-28-10-19(3,4)25)8-15(11)13-7-16(17(20)21-9-13)18-22-12(2)23-29-18/h5-9,24-25H,10H2,1-4H3,(H2,20,21)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295061
PNG
(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H24N4O3S2/c1-12-5-6-15(29(26,27)24-11-20(3,4)25)8-16(12)14-7-17(19(21)23-9-14)18-10-22-13(2)28-18/h5-10,24-25H,11H2,1-4H3,(H2,21,23)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295246
PNG
(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnn(C)n1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C20H26N6O3S/c1-13-5-6-15(30(28,29)24-8-7-20(2,3)27)10-16(13)14-9-17(19(21)22-11-14)18-12-23-26(4)25-18/h5-6,9-12,24,27H,7-8H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295258
PNG
(3-(6-Amino-5-(2-cyclopropyloxazol-5-yl)pyridin-3-y...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnc(o1)C1CC1)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C22H26N4O4S/c1-13-4-7-16(31(28,29)26-12-22(2,3)27)9-17(13)15-8-18(20(23)24-10-15)19-11-25-21(30-19)14-5-6-14/h4,7-11,14,26-27H,5-6,12H2,1-3H3,(H2,23,24)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295209
PNG
(5-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(c(Cl)cc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H23ClN4O4S/c1-11-5-16(21)18(30(27,28)24-10-20(3,4)26)8-14(11)13-7-15(19(22)23-9-13)17-6-12(2)25-29-17/h5-9,24,26H,10H2,1-4H3,(H2,22,23)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295235
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(O)COC1
Show InChI InChI=1S/C20H22N4O5S/c1-12-3-4-15(30(26,27)24-9-20(25)10-28-11-20)6-16(12)14-5-17(19(21)23-7-14)18-8-22-13(2)29-18/h3-8,24-25H,9-11H2,1-2H3,(H2,21,23)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295213
PNG
(3-(6-Amino-5-(2-methylthiazol-4-yl)pyridin-3-yl)-N...)
Show SMILES Cc1nc(cs1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H26N4O3S2/c1-13-3-8-18(31(28,29)26-16-4-6-17(27)7-5-16)10-19(13)15-9-20(22(23)24-11-15)21-12-30-14(2)25-21/h3,8-12,16-17,26-27H,4-7H2,1-2H3,(H2,23,24)/t16-,17-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295088
PNG
(US10112926, Example 21a)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NO[C@H]1CCOC1
Show InChI InChI=1S/C20H22N4O5S/c1-12-3-4-16(30(25,26)24-28-15-5-6-27-11-15)9-17(12)14-8-18(20(21)22-10-14)19-7-13(2)23-29-19/h3-4,7-10,15,24H,5-6,11H2,1-2H3,(H2,21,22)/t15-/m0/s1
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295117
PNG
((R)-3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@@H]1CCNC(=O)C1
Show InChI InChI=1S/C21H23N5O4S/c1-12-3-4-16(31(28,29)26-15-5-6-23-20(27)9-15)10-17(12)14-8-18(21(22)24-11-14)19-7-13(2)25-30-19/h3-4,7-8,10-11,15,26H,5-6,9H2,1-2H3,(H2,22,24)(H,23,27)/t15-/m1/s1
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US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295060
PNG
(3-[6-Amino-5-(3-methyl-isoxazol-5-yl)-pyridin-3-yl...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H26N4O4S/c1-13-5-6-16(30(27,28)24-8-7-21(3,4)26)11-17(13)15-10-18(20(22)23-12-15)19-9-14(2)25-29-19/h5-6,9-12,24,26H,7-8H2,1-4H3,(H2,22,23)
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295217
PNG
(US10112926, Example 95 | trans-3-(6-amino-5-(3-met...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NO[C@H]1C[C@H](O)C1
Show InChI InChI=1S/C20H22N4O5S/c1-11-3-4-16(30(26,27)24-28-15-7-14(25)8-15)9-17(11)13-6-18(20(21)22-10-13)19-5-12(2)23-29-19/h3-6,9-10,14-15,24-25H,7-8H2,1-2H3,(H2,21,22)/t14-,15-
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n/an/a 14n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295055
PNG
(3-[6-Amino-5-(2-methyl-thiazol-5-yl)-pyridin-3-yl]...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C19H22N4O3S2/c1-12-4-5-15(28(25,26)23-6-3-7-24)9-16(12)14-8-17(19(20)22-10-14)18-11-21-13(2)27-18/h4-5,8-11,23-24H,3,6-7H2,1-2H3,(H2,20,22)
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n/an/a 14n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295080
PNG
(3-(6-amino-5-(3- methylisoxazol-5- yl)pyridin-3-yl...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CCC[C@H](O)C1
Show InChI InChI=1S/C22H26N4O4S/c1-13-6-7-18(31(28,29)26-16-4-3-5-17(27)10-16)11-19(13)15-9-20(22(23)24-12-15)21-8-14(2)25-30-21/h6-9,11-12,16-17,26-27H,3-5,10H2,1-2H3,(H2,23,24)/t16-,17-/m0/s1
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n/an/a 14n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295210
PNG
(5-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(c(Cl)cc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C19H22ClN5O4S/c1-10-5-15(20)16(30(27,28)23-9-19(3,4)26)7-13(10)12-6-14(17(21)22-8-12)18-24-11(2)25-29-18/h5-8,23,26H,9H2,1-4H3,(H2,21,22)
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n/an/a 15n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295220
PNG
(3-(6-amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H26N4O4S/c1-13-3-8-18(31(28,29)26-16-4-6-17(27)7-5-16)10-19(13)15-9-20(22(23)25-11-15)21-12-24-14(2)30-21/h3,8-12,16-17,26-27H,4-7H2,1-2H3,(H2,23,25)/t16-,17-
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n/an/a 15n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295087
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NOCC(C)(C)O
Show InChI InChI=1S/C20H24N4O5S/c1-12-5-6-15(30(26,27)24-28-11-20(3,4)25)9-16(12)14-8-17(19(21)22-10-14)18-7-13(2)23-29-18/h5-10,24-25H,11H2,1-4H3,(H2,21,22)
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n/an/a 16n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295104
PNG
(3-(6-Amino-5-(3-(2,2,2-trifluoroethyl)isoxazol-5-y...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cc(CC(F)(F)F)no1)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C21H23F3N4O4S/c1-12-4-5-15(33(30,31)27-11-20(2,3)29)8-16(12)13-6-17(19(25)26-10-13)18-7-14(28-32-18)9-21(22,23)24/h4-8,10,27,29H,9,11H2,1-3H3,(H2,25,26)
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n/an/a 16n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295212
PNG
(3-(6-Amino-5-(5-methylthiazol-2-yl)pyridin-3-yl)-N...)
Show SMILES Cc1cnc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H26N4O3S2/c1-13-5-6-16(30(27,28)25-8-7-21(3,4)26)10-17(13)15-9-18(19(22)23-12-15)20-24-11-14(2)29-20/h5-6,9-12,25-26H,7-8H2,1-4H3,(H2,22,23)
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n/an/a 16n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295085
PNG
(1-((3-(6-amino-5-(3- methylisoxazol-5- yl)pyridin-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N1CCCC(C)(O)CC1
Show InChI InChI=1S/C23H28N4O4S/c1-15-5-6-18(32(29,30)27-9-4-7-23(3,28)8-10-27)13-19(15)17-12-20(22(24)25-14-17)21-11-16(2)26-31-21/h5-6,11-14,28H,4,7-10H2,1-3H3,(H2,24,25)
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n/an/a 16n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295059
PNG
(3-[6-Amino-5-(2-methyl-oxazol-5-yl)-pyridin-3-yl]-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C21H26N4O4S/c1-13-5-6-16(30(27,28)25-8-7-21(3,4)26)10-17(13)15-9-18(20(22)24-11-15)19-12-23-14(2)29-19/h5-6,9-12,25-26H,7-8H2,1-4H3,(H2,22,24)
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n/an/a 16n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295053
PNG
(US10112926, Example 8.1 | US10112926, Example 8.2)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC2(C[C@H](O)C2)C1
Show InChI InChI=1S/C22H25N5O4S/c1-12-3-4-17(32(29,30)27-15-7-22(8-15)9-16(28)10-22)6-18(12)14-5-19(20(23)24-11-14)21-25-13(2)26-31-21/h3-6,11,15-16,27-28H,7-10H2,1-2H3,(H2,23,24)/t15-,16-,22?
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n/an/a 17n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295149
PNG
((R)-3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1CCCCO1
Show InChI InChI=1S/C22H26N4O4S/c1-14-6-7-18(31(27,28)25-13-17-5-3-4-8-29-17)11-19(14)16-10-20(22(23)24-12-16)21-9-15(2)26-30-21/h6-7,9-12,17,25H,3-5,8,13H2,1-2H3,(H2,23,24)/t17-/m0/s1
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295118
PNG
((R)-3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)py...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC[C@H]1CCCO1
Show InChI InChI=1S/C20H23N5O4S/c1-12-5-6-16(30(26,27)23-11-15-4-3-7-28-15)9-17(12)14-8-18(19(21)22-10-14)20-24-13(2)25-29-20/h5-6,8-10,15,23H,3-4,7,11H2,1-2H3,(H2,21,22)/t15-/m1/s1
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n/an/a 18n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM295033
PNG
(US10112926, Example 4.1 | trans 3-(6-Amino-5-(1- m...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnn(C)c1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C22H27N5O3S/c1-14-3-8-19(31(29,30)26-17-4-6-18(28)7-5-17)10-20(14)15-9-21(22(23)24-11-15)16-12-25-27(2)13-16/h3,8-13,17-18,26,28H,4-7H2,1-2H3,(H2,23,24)/t17-,18-
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Novartis AG

US Patent


Assay Description
The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%