BindingDB logo
myBDB logout

Patent code US10112928

Compile Data Set for Download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295272
PNG
(6-(1-aminomethyl-3- methyl-butylamino)- 4-(6-isopr...)
Show SMILES CC(C)CC(CN)Nc1cc(Nc2ccc(C)c(n2)C(C)C)c(nn1)C(N)=O
Show InChI InChI=1S/C20H31N7O/c1-11(2)8-14(10-21)23-17-9-15(19(20(22)28)27-26-17)24-16-7-6-13(5)18(25-16)12(3)4/h6-7,9,11-12,14H,8,10,21H2,1-5H3,(H2,22,28)(H2,23,24,25,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295270
PNG
(6-(1-amino-4- methylpentan-2- ylamino)-4-(6-tert- ...)
Show SMILES CC(C)CC(CN)Nc1cc(Nc2cccc(n2)C(C)(C)C)c(nn1)C(N)=O
Show InChI InChI=1S/C20H31N7O/c1-12(2)9-13(11-21)23-17-10-14(18(19(22)28)27-26-17)24-16-8-6-7-15(25-16)20(3,4)5/h6-8,10,12-13H,9,11,21H2,1-5H3,(H2,22,28)(H2,23,24,25,26)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50007104
PNG
(CHEMBL3237572 | US10112928, Compound I-17)
Show SMILES CC(C)C[C@H](CN)Nc1cc(Nc2cccc(n2)C(C)(C)C)c(nn1)C(N)=O
Show InChI InChI=1S/C20H31N7O/c1-12(2)9-13(11-21)23-17-10-14(18(19(22)28)27-26-17)24-16-8-6-7-15(25-16)20(3,4)5/h6-8,10,12-13H,9,11,21H2,1-5H3,(H2,22,28)(H2,23,24,25,26)/t13-/m1/s1
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295281
PNG
(6-(2- aminoethylamino)-4- (6-(trifluoromethyl) pyr...)
Show SMILES NCCNc1cc(Nc2cccc(n2)C(F)(F)F)c(nn1)C(N)=O
Show InChI InChI=1S/C13H14F3N7O/c14-13(15,16)8-2-1-3-9(21-8)20-7-6-10(19-5-4-17)22-23-11(7)12(18)24/h1-3,6H,4-5,17H2,(H2,18,24)(H2,19,20,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295287
PNG
(6-(2- aminoethylamino)-4- (5-isopropyl-6- methoxyp...)
Show SMILES COc1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1C(C)C
Show InChI InChI=1S/C16H23N7O2/c1-9(2)10-4-5-12(21-16(10)25-3)20-11-8-13(19-7-6-17)22-23-14(11)15(18)24/h4-5,8-9H,6-7,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.25n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50007160
PNG
(CHEMBL3237578 | US10112928, Compound I-20)
Show SMILES COc1ccc(Nc2cc(NCCN)nnc2C(N)=O)nc1C(C)C
Show InChI InChI=1S/C16H23N7O2/c1-9(2)14-11(25-3)4-5-12(21-14)20-10-8-13(19-7-6-17)22-23-15(10)16(18)24/h4-5,8-9H,6-7,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a 11n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295289
PNG
(6-(2- aminoethylamino)-4- (6-isopropoxypyridin- 2-...)
Show SMILES CC(C)Oc1cccc(Nc2cc(NCCN)nnc2C(N)=O)n1
Show InChI InChI=1S/C15H21N7O2/c1-9(2)24-13-5-3-4-11(20-13)19-10-8-12(18-7-6-16)21-22-14(10)15(17)23/h3-5,8-9H,6-7,16H2,1-2H3,(H2,17,23)(H2,18,19,20,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.4n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295273
PNG
(6-(2- aminoethylamino)-4- (6-tert-butylpyridin- 2-...)
Show SMILES CC(C)(C)c1cccc(Nc2cc(NCCN)nnc2C(N)=O)n1
Show InChI InChI=1S/C16H23N7O/c1-16(2,3)11-5-4-6-12(21-11)20-10-9-13(19-8-7-17)22-23-14(10)15(18)24/h4-6,9H,7-8,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295283
PNG
(6-(2- aminoethylamino)-4- (6-(dimethylamino)- 5-me...)
Show SMILES CN(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1C
Show InChI InChI=1S/C15H22N8O/c1-9-4-5-11(20-15(9)23(2)3)19-10-8-12(18-7-6-16)21-22-13(10)14(17)24/h4-5,8H,6-7,16H2,1-3H3,(H2,17,24)(H2,18,19,20,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50007097
PNG
(CHEMBL3237566 | US10112928, Compound I-34)
Show SMILES Cc1ccc(Nc2cc(NCCN)nnc2C(N)=O)nc1C
Show InChI InChI=1S/C14H19N7O/c1-8-3-4-11(18-9(8)2)19-10-7-12(17-6-5-15)20-21-13(10)14(16)22/h3-4,7H,5-6,15H2,1-2H3,(H2,16,22)(H2,17,18,19,20)
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24.4n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50007187
PNG
(CHEMBL3237581 | US10112928, Compound I-32)
Show SMILES CC(C)c1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1F
Show InChI InChI=1S/C15H20FN7O/c1-8(2)13-9(16)3-4-11(21-13)20-10-7-12(19-6-5-17)22-23-14(10)15(18)24/h3-4,7-8H,5-6,17H2,1-2H3,(H2,18,24)(H2,19,20,21,22)
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 37.8n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50007161
PNG
(CHEMBL3237579 | US10112928, Compound I-26)
Show SMILES CCCc1nc(Nc2cc(NCCN)nnc2C(N)=O)ccc1OC
Show InChI InChI=1S/C16H23N7O2/c1-3-4-10-12(25-2)5-6-13(20-10)21-11-9-14(19-8-7-17)22-23-15(11)16(18)24/h5-6,9H,3-4,7-8,17H2,1-2H3,(H2,18,24)(H2,19,20,21,22)
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 38n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50011187
PNG
(CHEMBL3260323 | US10112928, Compound I-30)
Show SMILES Cc1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)ccc2C(N)=O)n1
Show InChI InChI=1S/C19H25N5O/c1-12-5-4-8-18(22-12)24-17-11-13(9-10-14(17)19(21)25)23-16-7-3-2-6-15(16)20/h4-5,8-11,15-16,23H,2-3,6-7,20H2,1H3,(H2,21,25)(H,22,24)/t15-,16+/m0/s1
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a 41.8n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295277
PNG
(6-(2-aminoethylamino)- 4-(6-(2-cyanopropan-2- yl)p...)
Show SMILES CC(C)(C#N)c1cccc(Nc2cc(NCCN)nnc2C(N)=O)n1
Show InChI InChI=1S/C16H20N8O/c1-16(2,9-18)11-4-3-5-12(22-11)21-10-8-13(20-7-6-17)23-24-14(10)15(19)25/h3-5,8H,6-7,17H2,1-2H3,(H2,19,25)(H2,20,21,22,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295271
PNG
(6-chloro-4-(3,5- dimethylphenyl- amino)pyridazine-...)
Show SMILES Cc1cc(C)cc(Nc2cc(Cl)nnc2C(N)=O)c1
Show InChI InChI=1S/C13H13ClN4O/c1-7-3-8(2)5-9(4-7)16-10-6-11(14)17-18-12(10)13(15)19/h3-6H,1-2H3,(H2,15,19)(H,16,17)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 124n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295275
PNG
(6-((1- aminocyclopropyl) methylamino)-4-(6-tert- b...)
Show SMILES CC(C)(C)c1cccc(Nc2cc(NCC3(N)CC3)nnc2C(N)=O)n1
Show InChI InChI=1S/C18H25N7O/c1-17(2,3)12-5-4-6-13(23-12)22-11-9-14(21-10-18(20)7-8-18)24-25-15(11)16(19)26/h4-6,9H,7-8,10,20H2,1-3H3,(H2,19,26)(H2,21,22,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 135n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295279
PNG
(6-(2-aminoethylamino)- 4-(6-(2-hydroxypropan- 2-yl...)
Show SMILES CC(C)(O)c1cccc(Nc2cc(NCCN)nnc2C(N)=O)n1
Show InChI InChI=1S/C15H21N7O2/c1-15(2,24)10-4-3-5-11(20-10)19-9-8-12(18-7-6-16)21-22-13(9)14(17)23/h3-5,8,24H,6-7,16H2,1-2H3,(H2,17,23)(H2,18,19,20,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 161n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295284
PNG
(6-(2- aminoethylamino)-4- (2-tert- butylpyrimidin-...)
Show SMILES CC(C)(C)c1nccc(Nc2cc(NCCN)nnc2C(N)=O)n1
Show InChI InChI=1S/C15H22N8O/c1-15(2,3)14-19-6-4-10(21-14)20-9-8-11(18-7-5-16)22-23-12(9)13(17)24/h4,6,8H,5,7,16H2,1-3H3,(H2,17,24)(H2,18,19,20,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295269
PNG
(4-(6-cyclopropyl- pyridin-2-ylamino)-6- oxo-1,6-di...)
Show SMILES NC(=O)c1n[nH]c(=O)cc1Nc1cccc(n1)C1CC1
Show InChI InChI=1S/C13H13N5O2/c14-13(20)12-9(6-11(19)17-18-12)16-10-3-1-2-8(15-10)7-4-5-7/h1-3,6-7H,4-5H2,(H2,14,20)(H2,15,16,17,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 225n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295266
PNG
(4-(6-methylpyridin-2- ylamino)-6-(o- tolyloxy)pyri...)
Show SMILES Cc1cccc(Nc2cc(Oc3ccccc3C)nnc2C(N)=O)n1
Show InChI InChI=1S/C18H17N5O2/c1-11-6-3-4-8-14(11)25-16-10-13(17(18(19)24)23-22-16)21-15-9-5-7-12(2)20-15/h3-10H,1-2H3,(H2,19,24)(H,20,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 373n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295264
PNG
(6-(2-cyanophenoxy)- 4-(6-methylpyridin-2- ylamino)...)
Show SMILES Cc1cccc(Nc2cc(Oc3ccccc3C#N)nnc2C(N)=O)n1
Show InChI InChI=1S/C18H14N6O2/c1-11-5-4-8-15(21-11)22-13-9-16(23-24-17(13)18(20)25)26-14-7-3-2-6-12(14)10-19/h2-9H,1H3,(H2,20,25)(H,21,22,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 385n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295265
PNG
(6-(2-ethylphenoxy)- 4-(6-methylpyridin-2- ylamino)...)
Show SMILES CCc1ccccc1Oc1cc(Nc2cccc(C)n2)c(nn1)C(N)=O
Show InChI InChI=1S/C19H19N5O2/c1-3-13-8-4-5-9-15(13)26-17-11-14(18(19(20)25)24-23-17)22-16-10-6-7-12(2)21-16/h4-11H,3H2,1-2H3,(H2,20,25)(H,21,22,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 473n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM50007100
PNG
(CHEMBL3237569 | US10112928, Compound I-4)
Show SMILES Cc1cccc(Nc2cc(Oc3cccc(F)c3)nnc2C(N)=O)n1
Show InChI InChI=1S/C17H14FN5O2/c1-10-4-2-7-14(20-10)21-13-9-15(22-23-16(13)17(19)24)25-12-6-3-5-11(18)8-12/h2-9H,1H3,(H2,19,24)(H,20,21,22)
PDB

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 671n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295285
PNG
(6-(2- aminoethylamino)-4- (6-(2- methoxypropan-2- ...)
Show SMILES COC(C)(C)c1cccc(Nc2cc(NCCN)nnc2C(N)=O)n1
Show InChI InChI=1S/C16H23N7O2/c1-16(2,25-3)11-5-4-6-12(21-11)20-10-9-13(19-8-7-17)22-23-14(10)15(18)24/h4-6,9H,7-8,17H2,1-3H3,(H2,18,24)(H2,19,20,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 755n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295260
PNG
(6-(3-cyanophenoxy)- 4-(6-methylpyridin-2- ylamino)...)
Show SMILES Cc1cccc(Nc2cc(Oc3cccc(c3)C#N)nnc2C(N)=O)n1
Show InChI InChI=1S/C18H14N6O2/c1-11-4-2-7-15(21-11)22-14-9-16(23-24-17(14)18(20)25)26-13-6-3-5-12(8-13)10-19/h2-9H,1H3,(H2,20,25)(H,21,22,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 965n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295259
PNG
(4-(6-methylpyridin-2- ylamino)-6- phenoxypyridazin...)
Show SMILES Cc1cccc(Nc2cc(Oc3ccccc3)nnc2C(N)=O)n1
Show InChI InChI=1S/C17H15N5O2/c1-11-6-5-9-14(19-11)20-13-10-15(21-22-16(13)17(18)23)24-12-7-3-2-4-8-12/h2-10H,1H3,(H2,18,23)(H,19,20,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.32E+3n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295267
PNG
(6-(4-chloro-2- cyanophenoxy)-4-(6- methylpyridin-2...)
Show SMILES Cc1cccc(Nc2cc(Oc3ccc(Cl)cc3C#N)nnc2C(N)=O)n1
Show InChI InChI=1S/C18H13ClN6O2/c1-10-3-2-4-15(22-10)23-13-8-16(24-25-17(13)18(21)26)27-14-6-5-12(19)7-11(14)9-20/h2-8H,1H3,(H2,21,26)(H,22,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.41E+3n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295263
PNG
(4-(6-methylpyridin-2- ylamino)-6-(pyridin- 3-yloxy...)
Show SMILES Cc1cccc(Nc2cc(Oc3cccnc3)nnc2C(N)=O)n1
Show InChI InChI=1S/C16H14N6O2/c1-10-4-2-6-13(19-10)20-12-8-14(21-22-15(12)16(17)23)24-11-5-3-7-18-9-11/h2-9H,1H3,(H2,17,23)(H,19,20,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+3n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295268
PNG
(6-(2- cyclopropylphenoxy)- 4-(6-methylpyridin-2- y...)
Show SMILES Cc1cccc(Nc2cc(Oc3ccccc3C3CC3)nnc2C(N)=O)n1
Show InChI InChI=1S/C20H19N5O2/c1-12-5-4-8-17(22-12)23-15-11-18(24-25-19(15)20(21)26)27-16-7-3-2-6-14(16)13-9-10-13/h2-8,11,13H,9-10H2,1H3,(H2,21,26)(H,22,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.18E+3n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295261
PNG
(6-(3-(2-aminopropan- 2-yl)phenoxy)-4-(6- methylpyr...)
Show SMILES Cc1cccc(Nc2cc(Oc3cccc(c3)C(C)(C)N)nnc2C(N)=O)n1
Show InChI InChI=1S/C20H22N6O2/c1-12-6-4-9-16(23-12)24-15-11-17(25-26-18(15)19(21)27)28-14-8-5-7-13(10-14)20(2,3)22/h4-11H,22H2,1-3H3,(H2,21,27)(H,23,24,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.24E+3n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295278
PNG
(2-(3-amino-propyl)-4- m-tolylamino- pyrimidine-5-c...)
Show SMILES Cc1cccc(Nc2nc(CCCN)ncc2C(N)=O)c1
Show InChI InChI=1S/C15H19N5O/c1-10-4-2-5-11(8-10)19-15-12(14(17)21)9-18-13(20-15)6-3-7-16/h2,4-5,8-9H,3,6-7,16H2,1H3,(H2,17,21)(H,18,19,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.54E+3n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
SYK RPA purified, truncated construct of Spleen Tyrosine Kinase aa 360-635


(Homo sapiens (human))
BDBM295280
PNG
(6-(2-aminoethylamino)- 4-(4,6- dimethylpyrimidin-2...)
Show SMILES Cc1cc(C)nc(Nc2cc(NCCN)nnc2C(N)=O)n1
Show InChI InChI=1S/C13H18N8O/c1-7-5-8(2)18-13(17-7)19-9-6-10(16-4-3-14)20-21-11(9)12(15)22/h5-6H,3-4,14H2,1-2H3,(H2,15,22)(H2,16,17,18,19,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.98E+3n/an/an/an/a7.5n/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This assay is performed in 96-well format for IC50 determination with ...


US Patent US10112928 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%