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Patent code US10112955

Compile Data Set for Download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297365
PNG
(7-chloro-3-methyl-5-(pyrimidin-4-ylamino)isoindoli...)
Show SMILES CC1NC(=O)c2c1cc(Nc1ccncn1)cc2Cl
Show InChI InChI=1S/C13H11ClN4O/c1-7-9-4-8(18-11-2-3-15-6-16-11)5-10(14)12(9)13(19)17-7/h2-7H,1H3,(H,17,19)(H,15,16,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297367
PNG
(5-(pyrimidin-4-ylamino)-3-(thiophen-3-yl)isoindoli...)
Show SMILES O=C1NC(c2ccsc2)c2cc(Nc3ccncn3)ccc12
Show InChI InChI=1S/C16H12N4OS/c21-16-12-2-1-11(19-14-3-5-17-9-18-14)7-13(12)15(20-16)10-4-6-22-8-10/h1-9,15H,(H,20,21)(H,17,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297367
PNG
(5-(pyrimidin-4-ylamino)-3-(thiophen-3-yl)isoindoli...)
Show SMILES O=C1NC(c2ccsc2)c2cc(Nc3ccncn3)ccc12
Show InChI InChI=1S/C16H12N4OS/c21-16-12-2-1-11(19-14-3-5-17-9-18-14)7-13(12)15(20-16)10-4-6-22-8-10/h1-9,15H,(H,20,21)(H,17,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297374
PNG
(Synthesis of 5-((6-aminopyrimidin-4-yl)amino)-3,3,...)
Show SMILES Cc1cc(Nc2cc(N)ncn2)cc2c1C(=O)NC2(C)C
Show InChI InChI=1S/C15H17N5O/c1-8-4-9(19-12-6-11(16)17-7-18-12)5-10-13(8)14(21)20-15(10,2)3/h4-7H,1-3H3,(H,20,21)(H3,16,17,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297387
PNG
(6'-((6-amino-5-chloropyrimidin-4-yl)amino)-4'-meth...)
Show SMILES Cc1cc(Nc2ncnc(N)c2Cl)cc2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C18H20ClN5O/c1-10-7-11(23-16-14(19)15(20)21-9-22-16)8-12-13(10)17(25)24-18(12)5-3-2-4-6-18/h7-9H,2-6H2,1H3,(H,24,25)(H3,20,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297344
PNG
(N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)a...)
Show SMILES CC(=O)Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1
Show InChI InChI=1S/C14H13N5O2/c1-8(20)18-12-5-13(17-7-16-12)19-10-2-3-11-9(4-10)6-15-14(11)21/h2-5,7H,6H2,1H3,(H,15,21)(H2,16,17,18,19,20)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297351
PNG
(N-(6-((3-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)am...)
Show SMILES CC1CC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)cc12
Show InChI InChI=1S/C18H18N4O2/c1-10-6-15(23)13-5-4-12(7-14(10)13)21-16-8-17(20-9-19-16)22-18(24)11-2-3-11/h4-5,7-11H,2-3,6H2,1H3,(H2,19,20,21,22,24)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297366
PNG
(7-chloro-3,3-dimethyl-5-(pyrimidin-4-ylamino)isoin...)
Show SMILES CC1(C)NC(=O)c2c1cc(Nc1ccncn1)cc2Cl
Show InChI InChI=1S/C14H13ClN4O/c1-14(2)9-5-8(18-11-3-4-16-7-17-11)6-10(15)12(9)13(20)19-14/h3-7H,1-2H3,(H,19,20)(H,16,17,18)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297372
PNG
(N-(4-((1-methyl-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c...)
Show SMILES CC1NC(=O)c2cnc(Nc3ccnc(NC(=O)C4CC4)c3)cc12
Show InChI InChI=1S/C17H17N5O2/c1-9-12-7-15(19-8-13(12)17(24)20-9)21-11-4-5-18-14(6-11)22-16(23)10-2-3-10/h4-10H,2-3H2,1H3,(H,20,24)(H2,18,19,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297380
PNG
(6'-((6-aminopyrimidin-4-yl)amino)-4'-methylspiro[c...)
Show SMILES Cc1cc(Nc2cc(N)ncn2)cc2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C18H21N5O/c1-11-7-12(22-15-9-14(19)20-10-21-15)8-13-16(11)17(24)23-18(13)5-3-2-4-6-18/h7-10H,2-6H2,1H3,(H,23,24)(H3,19,20,21,22)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297381
PNG
(5-((6-aminopyrimidin-4-yl)amino)-4-chloro-3,3-dime...)
Show SMILES CC1(C)NC(=O)c2ccc(Nc3cc(N)ncn3)c(Cl)c12
Show InChI InChI=1S/C14H14ClN5O/c1-14(2)11-7(13(21)20-14)3-4-8(12(11)15)19-10-5-9(16)17-6-18-10/h3-6H,1-2H3,(H,20,21)(H3,16,17,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297382
PNG
(6'-((6-amino-5-ethylpyrimidin-4-yl)amino)-4'-methy...)
Show SMILES CCc1c(N)ncnc1Nc1cc2c(C(=O)NC22CCCCC2)c(C)c1
Show InChI InChI=1S/C20H25N5O/c1-3-14-17(21)22-11-23-18(14)24-13-9-12(2)16-15(10-13)20(25-19(16)26)7-5-4-6-8-20/h9-11H,3-8H2,1-2H3,(H,25,26)(H3,21,22,23,24)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297365
PNG
(7-chloro-3-methyl-5-(pyrimidin-4-ylamino)isoindoli...)
Show SMILES CC1NC(=O)c2c1cc(Nc1ccncn1)cc2Cl
Show InChI InChI=1S/C13H11ClN4O/c1-7-9-4-8(18-11-2-3-15-6-16-11)5-10(14)12(9)13(19)17-7/h2-7H,1H3,(H,17,19)(H,15,16,18)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297373
PNG
(Synthesis of 5-((6-aminopyrimidin-4-yl)amino)-7-ch...)
Show SMILES CC1(C)NC(=O)c2c1cc(Nc1cc(N)ncn1)cc2Cl
Show InChI InChI=1S/C14H14ClN5O/c1-14(2)8-3-7(4-9(15)12(8)13(21)20-14)19-11-5-10(16)17-6-18-11/h3-6H,1-2H3,(H,20,21)(H3,16,17,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297377
PNG
(6'-((6-aminopyrimidin-4-yl)amino)-4'-chlorospiro[c...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)cc2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C21H22ClN5O2/c22-15-9-13(8-14-18(15)20(29)27-21(14)6-2-1-3-7-21)25-16-10-17(24-11-23-16)26-19(28)12-4-5-12/h8-12H,1-7H2,(H,27,29)(H2,23,24,25,26,28)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297386
PNG
(6'-((6-amino-5-methoxypyrimidin-4-yl)amino)-4'-met...)
Show SMILES COc1c(N)ncnc1Nc1cc2c(C(=O)NC22CCCCC2)c(C)c1
Show InChI InChI=1S/C19H23N5O2/c1-11-8-12(23-17-15(26-2)16(20)21-10-22-17)9-13-14(11)18(25)24-19(13)6-4-3-5-7-19/h8-10H,3-7H2,1-2H3,(H,24,25)(H3,20,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297349
PNG
(N-(6-((3-methyl-1-oxoisoindolin-5-yl)amino)pyrimid...)
Show SMILES CC1NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)cc12
Show InChI InChI=1S/C17H17N5O2/c1-9-13-6-11(4-5-12(13)17(24)20-9)21-14-7-15(19-8-18-14)22-16(23)10-2-3-10/h4-10H,2-3H2,1H3,(H,20,24)(H2,18,19,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297356
PNG
(N-(4-((3-methyl-1-oxoisoindolin-5-yl) amino) pyrid...)
Show SMILES CC1NC(=O)c2ccc(Nc3ccnc(NC(=O)C4CC4)c3)cc12
Show InChI InChI=1S/C18H18N4O2/c1-10-15-8-12(4-5-14(15)18(24)20-10)21-13-6-7-19-16(9-13)22-17(23)11-2-3-11/h4-11H,2-3H2,1H3,(H,20,24)(H2,19,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297383
PNG
(6'-((5-methoxypyrimidin-4-yl)amino)-4'-methylspiro...)
Show SMILES COc1cncnc1Nc1cc2c(C(=O)NC22CCCCC2)c(C)c1
Show InChI InChI=1S/C19H22N4O2/c1-12-8-13(22-17-15(25-2)10-20-11-21-17)9-14-16(12)18(24)23-19(14)6-4-3-5-7-19/h8-11H,3-7H2,1-2H3,(H,23,24)(H,20,21,22)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297345
PNG
(N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)c...)
Show SMILES O=C(Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1)C1CC1
Show InChI InChI=1S/C16H15N5O2/c22-15(9-1-2-9)21-14-6-13(18-8-19-14)20-11-3-4-12-10(5-11)7-17-16(12)23/h3-6,8-9H,1-2,7H2,(H,17,23)(H2,18,19,20,21,22)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297366
PNG
(7-chloro-3,3-dimethyl-5-(pyrimidin-4-ylamino)isoin...)
Show SMILES CC1(C)NC(=O)c2c1cc(Nc1ccncn1)cc2Cl
Show InChI InChI=1S/C14H13ClN4O/c1-14(2)9-5-8(18-11-3-4-16-7-17-11)6-10(15)12(9)13(20)19-14/h3-7H,1-2H3,(H,19,20)(H,16,17,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297372
PNG
(N-(4-((1-methyl-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c...)
Show SMILES CC1NC(=O)c2cnc(Nc3ccnc(NC(=O)C4CC4)c3)cc12
Show InChI InChI=1S/C17H17N5O2/c1-9-12-7-15(19-8-13(12)17(24)20-9)21-11-4-5-18-14(6-11)22-16(23)10-2-3-10/h4-10H,2-3H2,1H3,(H,20,24)(H2,18,19,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297379
PNG
(5-((6-amino-5-chloropyrimidin-4-yl)amino)-7-chloro...)
Show SMILES CC1(C)NC(=O)c2c1cc(Nc1ncnc(N)c1Cl)cc2Cl
Show InChI InChI=1S/C14H13Cl2N5O/c1-14(2)7-3-6(4-8(15)9(7)13(22)21-14)20-12-10(16)11(17)18-5-19-12/h3-5H,1-2H3,(H,21,22)(H3,17,18,19,20)
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eFFECTOR Therapeutics, Inc.

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US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297345
PNG
(N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)c...)
Show SMILES O=C(Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1)C1CC1
Show InChI InChI=1S/C16H15N5O2/c22-15(9-1-2-9)21-14-6-13(18-8-19-14)20-11-3-4-12-10(5-11)7-17-16(12)23/h3-6,8-9H,1-2,7H2,(H,17,23)(H2,18,19,20,21,22)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297373
PNG
(Synthesis of 5-((6-aminopyrimidin-4-yl)amino)-7-ch...)
Show SMILES CC1(C)NC(=O)c2c1cc(Nc1cc(N)ncn1)cc2Cl
Show InChI InChI=1S/C14H14ClN5O/c1-14(2)8-3-7(4-9(15)12(8)13(21)20-14)19-11-5-10(16)17-6-18-11/h3-6H,1-2H3,(H,20,21)(H3,16,17,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297388
PNG
(6'-((6-amino-5-chloropyrimidin-4-yl)amino)-4'-chlo...)
Show SMILES Nc1ncnc(Nc2cc3c(C(=O)NC33CCCCC3)c(Cl)c2)c1Cl
Show InChI InChI=1S/C17H17Cl2N5O/c18-11-7-9(23-15-13(19)14(20)21-8-22-15)6-10-12(11)16(25)24-17(10)4-2-1-3-5-17/h6-8H,1-5H2,(H,24,25)(H3,20,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297349
PNG
(N-(6-((3-methyl-1-oxoisoindolin-5-yl)amino)pyrimid...)
Show SMILES CC1NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)cc12
Show InChI InChI=1S/C17H17N5O2/c1-9-13-6-11(4-5-12(13)17(24)20-9)21-14-7-15(19-8-18-14)22-16(23)10-2-3-10/h4-10H,2-3H2,1H3,(H,20,24)(H2,18,19,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297375
PNG
(4'-chloro-6'-(pyrimidin-4-ylamino)spiro[cyclohexan...)
Show SMILES Clc1cc(Nc2ccncn2)cc2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H17ClN4O/c18-13-9-11(21-14-4-7-19-10-20-14)8-12-15(13)16(23)22-17(12)5-2-1-3-6-17/h4,7-10H,1-3,5-6H2,(H,22,23)(H,19,20,21)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297376
PNG
(6'-((6-aminopyrimidin-4-yl)amino)-4'-methylspiro[c...)
Show SMILES Nc1cc(Nc2cc3c(C(=O)NC33CCCC3)c(Cl)c2)ncn1
Show InChI InChI=1S/C16H16ClN5O/c17-11-6-9(21-13-7-12(18)19-8-20-13)5-10-14(11)15(23)22-16(10)3-1-2-4-16/h5-8H,1-4H2,(H,22,23)(H3,18,19,20,21)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297342
PNG
(3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (...)
Show SMILES CC1NC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C13H12N4O/c1-8-11-6-9(2-3-10(11)13(18)16-8)17-12-4-5-14-7-15-12/h2-8H,1H3,(H,16,18)(H,14,15,17)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297369
PNG
(Synthesis of 5-(6,7-dihydro-5H-pyrrolo[2,3-d]pyrim...)
Show SMILES CC1NC(=O)c2ccc(Nc3ncnc4NCCc34)cc12
Show InChI InChI=1S/C15H15N5O/c1-8-12-6-9(2-3-10(12)15(21)19-8)20-14-11-4-5-16-13(11)17-7-18-14/h2-3,6-8H,4-5H2,1H3,(H,19,21)(H2,16,17,18,20)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297364
PNG
(Synthesis of 3,7-dimethyl-5-(pyrimidin-4-ylamino)i...)
Show SMILES CC1NC(=O)c2c1cc(Nc1ccncn1)cc2C
Show InChI InChI=1S/C14H14N4O/c1-8-5-10(18-12-3-4-15-7-16-12)6-11-9(2)17-14(19)13(8)11/h3-7,9H,1-2H3,(H,17,19)(H,15,16,18)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297346
PNG
(3-isopropyl-5-(pyrimidin-4-ylamino)isoindolin-1-on...)
Show SMILES CC(C)C1NC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C15H16N4O/c1-9(2)14-12-7-10(3-4-11(12)15(20)19-14)18-13-5-6-16-8-17-13/h3-9,14H,1-2H3,(H,19,20)(H,16,17,18)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297384
PNG
(6'-((6-amino-5-methylpyrimidin-4-yl)amino)-4'-meth...)
Show SMILES Cc1cc(Nc2ncnc(N)c2C)cc2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C19H23N5O/c1-11-8-13(23-17-12(2)16(20)21-10-22-17)9-14-15(11)18(25)24-19(14)6-4-3-5-7-19/h8-10H,3-7H2,1-2H3,(H,24,25)(H3,20,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297378
PNG
(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazole-5-c...)
Show SMILES NC(=O)c1ccc2ncn(-c3cc(N)ncn3)c2c1
Show InChI InChI=1S/C12H10N6O/c13-10-4-11(16-5-15-10)18-6-17-8-2-1-7(12(14)19)3-9(8)18/h1-6H,(H2,14,19)(H2,13,15,16)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297355
PNG
(Synthesis of 3-methyl-6-(pyrimidin-4-ylamino)-3, 4...)
Show SMILES CC1Cc2cc(Nc3ccncn3)ccc2C(=O)N1
Show InChI InChI=1S/C14H14N4O/c1-9-6-10-7-11(2-3-12(10)14(19)17-9)18-13-4-5-15-8-16-13/h2-5,7-9H,6H2,1H3,(H,17,19)(H,15,16,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297347
PNG
(3,3-dimethyl-5-(pyrimidin-4-ylamino)isoindolin-1-o...)
Show SMILES CC1(C)NC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H14N4O/c1-14(2)11-7-9(3-4-10(11)13(19)18-14)17-12-5-6-15-8-16-12/h3-8H,1-2H3,(H,18,19)(H,15,16,17)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297343
PNG
(Synthesis of 6-(pyrimidin-4-ylamino)-3,4-dihydrois...)
Show SMILES O=C1NCCc2cc(Nc3ccncn3)ccc12
Show InChI InChI=1S/C13H12N4O/c18-13-11-2-1-10(7-9(11)3-6-15-13)17-12-4-5-14-8-16-12/h1-2,4-5,7-8H,3,6H2,(H,15,18)(H,14,16,17)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297368
PNG
(5-(7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-yla...)
Show SMILES CC1NC(=O)c2ccc(Nc3ncnc4NCCOc34)cc12
Show InChI InChI=1S/C15H15N5O2/c1-8-11-6-9(2-3-10(11)15(21)19-8)20-14-12-13(17-7-18-14)16-4-5-22-12/h2-3,6-8H,4-5H2,1H3,(H,19,21)(H2,16,17,18,20)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297354
PNG
(4-methyl-6-(pyrimidin-4-ylamino)-3,4-dihydroisoqui...)
Show SMILES CC1CNC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H14N4O/c1-9-7-16-14(19)11-3-2-10(6-12(9)11)18-13-4-5-15-8-17-13/h2-6,8-9H,7H2,1H3,(H,16,19)(H,15,17,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297341
PNG
(5-((6-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4...)
Show SMILES Cn1cc(Nc2cc(Nc3ccc4C(=O)NCc4c3)ncn2)cn1
Show InChI InChI=1S/C16H15N7O/c1-23-8-12(7-20-23)22-15-5-14(18-9-19-15)21-11-2-3-13-10(4-11)6-17-16(13)24/h2-5,7-9H,6H2,1H3,(H,17,24)(H2,18,19,21,22)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297385
PNG
(6'-((5-ethylpyrimidin-4-yl)amino)-4'-methylspiro[c...)
Show SMILES CCc1cncnc1Nc1cc2c(C(=O)NC22CCCCC2)c(C)c1
Show InChI InChI=1S/C20H24N4O/c1-3-14-11-21-12-22-18(14)23-15-9-13(2)17-16(10-15)20(24-19(17)25)7-5-4-6-8-20/h9-12H,3-8H2,1-2H3,(H,24,25)(H,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297351
PNG
(N-(6-((3-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)am...)
Show SMILES CC1CC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)cc12
Show InChI InChI=1S/C18H18N4O2/c1-10-6-15(23)13-5-4-12(7-14(10)13)21-16-8-17(20-9-19-16)22-18(24)11-2-3-11/h4-5,7-11H,2-3,6H2,1H3,(H2,19,20,21,22,24)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297343
PNG
(Synthesis of 6-(pyrimidin-4-ylamino)-3,4-dihydrois...)
Show SMILES O=C1NCCc2cc(Nc3ccncn3)ccc12
Show InChI InChI=1S/C13H12N4O/c18-13-11-2-1-10(7-9(11)3-6-15-13)17-12-4-5-14-8-16-12/h1-2,4-5,7-8H,3,6H2,(H,15,18)(H,14,16,17)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297342
PNG
(3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (...)
Show SMILES CC1NC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C13H12N4O/c1-8-11-6-9(2-3-10(11)13(18)16-8)17-12-4-5-14-7-15-12/h2-8H,1H3,(H,16,18)(H,14,15,17)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297336
PNG
(5-((9H-purin-6-yl)amino)isoindolin-1-one (Cpd. No....)
Show SMILES O=C1NCc2cc(Nc3ncnc4[nH]cnc34)ccc12
Show InChI InChI=1S/C13H10N6O/c20-13-9-2-1-8(3-7(9)4-14-13)19-12-10-11(16-5-15-10)17-6-18-12/h1-3,5-6H,4H2,(H,14,20)(H2,15,16,17,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297344
PNG
(N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)a...)
Show SMILES CC(=O)Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1
Show InChI InChI=1S/C14H13N5O2/c1-8(20)18-12-5-13(17-7-16-12)19-10-2-3-11-9(4-10)6-15-14(11)21/h2-5,7H,6H2,1H3,(H,15,21)(H2,16,17,18,19,20)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297337
PNG
(5-((9H-purin-6-yl)amino)-2-methylisoindolin-1-one ...)
Show SMILES CN1Cc2cc(Nc3ncnc4[nH]cnc34)ccc2C1=O
Show InChI InChI=1S/C14H12N6O/c1-20-5-8-4-9(2-3-10(8)14(20)21)19-13-11-12(16-6-15-11)17-7-18-13/h2-4,6-7H,5H2,1H3,(H2,15,16,17,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297364
PNG
(Synthesis of 3,7-dimethyl-5-(pyrimidin-4-ylamino)i...)
Show SMILES CC1NC(=O)c2c1cc(Nc1ccncn1)cc2C
Show InChI InChI=1S/C14H14N4O/c1-8-5-10(18-12-3-4-15-7-16-12)6-11-9(2)17-14(19)13(8)11/h3-7,9H,1-2H3,(H,17,19)(H,15,16,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297346
PNG
(3-isopropyl-5-(pyrimidin-4-ylamino)isoindolin-1-on...)
Show SMILES CC(C)C1NC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C15H16N4O/c1-9(2)14-12-7-10(3-4-11(12)15(20)19-14)18-13-5-6-16-8-17-13/h3-9,14H,1-2H3,(H,19,20)(H,16,17,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297369
PNG
(Synthesis of 5-(6,7-dihydro-5H-pyrrolo[2,3-d]pyrim...)
Show SMILES CC1NC(=O)c2ccc(Nc3ncnc4NCCc34)cc12
Show InChI InChI=1S/C15H15N5O/c1-8-12-6-9(2-3-10(12)15(21)19-8)20-14-11-4-5-16-13(11)17-7-18-14/h2-3,6-8H,4-5H2,1H3,(H,19,21)(H2,16,17,18,20)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297338
PNG
(5-(pyrimidin-4-ylamino)isoindolin-1-one (Cpd. No. ...)
Show SMILES O=C1NCc2cc(Nc3ccncn3)ccc12
Show InChI InChI=1S/C12H10N4O/c17-12-10-2-1-9(5-8(10)6-14-12)16-11-3-4-13-7-15-11/h1-5,7H,6H2,(H,14,17)(H,13,15,16)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297361
PNG
(6-(pyrimidin-4-ylamino)-1,1a,2,7b-tetrahydro-3H-cy...)
Show SMILES O=C1NC2CC2c2cc(Nc3ccncn3)ccc12
Show InChI InChI=1S/C14H12N4O/c19-14-9-2-1-8(17-13-3-4-15-7-16-13)5-10(9)11-6-12(11)18-14/h1-5,7,11-12H,6H2,(H,18,19)(H,15,16,17)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297355
PNG
(Synthesis of 3-methyl-6-(pyrimidin-4-ylamino)-3, 4...)
Show SMILES CC1Cc2cc(Nc3ccncn3)ccc2C(=O)N1
Show InChI InChI=1S/C14H14N4O/c1-9-6-10-7-11(2-3-12(10)14(19)17-9)18-13-4-5-15-8-16-13/h2-5,7-9H,6H2,1H3,(H,17,19)(H,15,16,18)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297352
PNG
(2,3-dimethyl-5-(pyrimidin-4-ylamino)isoindolin-1-o...)
Show SMILES CC1N(C)C(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H14N4O/c1-9-12-7-10(17-13-5-6-15-8-16-13)3-4-11(12)14(19)18(9)2/h3-9H,1-2H3,(H,15,16,17)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297371
PNG
(4-[(3-methyl-1-oxo-isoindolin-5-yl)amino]-5,7-dihy...)
Show SMILES CC1NC(=O)c2ccc(Nc3ncnc4NC(=O)Cc34)cc12
Show InChI InChI=1S/C15H13N5O2/c1-7-10-4-8(2-3-9(10)15(22)18-7)19-13-11-5-12(21)20-14(11)17-6-16-13/h2-4,6-7H,5H2,1H3,(H,18,22)(H2,16,17,19,20,21)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297359
PNG
(6-(pyrimidin-4-ylamino)benzo[d]isothiazol-3(2H)-on...)
Show SMILES O=c1[nH]sc2cc(Nc3ccncn3)ccc12
Show InChI InChI=1S/C11H8N4OS/c16-11-8-2-1-7(5-9(8)17-15-11)14-10-3-4-12-6-13-10/h1-6H,(H,15,16)(H,12,13,14)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297357
PNG
(3-methyl-5-((2-(methyl amino) pyridin-4-yl) amino)...)
Show SMILES CNc1cc(Nc2ccc3C(=O)NC(C)c3c2)ccn1
Show InChI InChI=1S/C15H16N4O/c1-9-13-7-10(3-4-12(13)15(20)18-9)19-11-5-6-17-14(8-11)16-2/h3-9H,1-2H3,(H,18,20)(H2,16,17,19)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297362
PNG
(3-amino-3-methyl-5-(pyrimidin-4-ylamino)-2,3-dihyd...)
Show SMILES CC1(N)CC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H14N4O/c1-14(15)7-12(19)10-3-2-9(6-11(10)14)18-13-4-5-16-8-17-13/h2-6,8H,7,15H2,1H3,(H,16,17,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297360
PNG
(3-amino-5-(pyrimidin-4-ylamino)-2,3-dihydro-1H-ind...)
Show SMILES NC1CC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C13H12N4O/c14-11-6-12(18)9-2-1-8(5-10(9)11)17-13-3-4-15-7-16-13/h1-5,7,11H,6,14H2,(H,15,16,17)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297354
PNG
(4-methyl-6-(pyrimidin-4-ylamino)-3,4-dihydroisoqui...)
Show SMILES CC1CNC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H14N4O/c1-9-7-16-14(19)11-3-2-10(6-12(9)11)18-13-4-5-15-8-17-13/h2-6,8-9H,7H2,1H3,(H,16,19)(H,15,17,18)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297350
PNG
(N-(6-((3-methyl-1-oxoisoindolin-5-yl)amino)pyrimid...)
Show SMILES CC1NC(=O)c2ccc(Nc3cc(NC(=O)C(C)(C)C)ncn3)cc12
Show InChI InChI=1S/C18H21N5O2/c1-10-13-7-11(5-6-12(13)16(24)21-10)22-14-8-15(20-9-19-14)23-17(25)18(2,3)4/h5-10H,1-4H3,(H,21,24)(H2,19,20,22,23,25)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297348
PNG
(3-methyl-5-((6-(methylthio)pyrimidin-4-yl)amino)is...)
Show SMILES CSc1cc(Nc2ccc3C(=O)NC(C)c3c2)ncn1
Show InChI InChI=1S/C14H14N4OS/c1-8-11-5-9(3-4-10(11)14(19)17-8)18-12-6-13(20-2)16-7-15-12/h3-8H,1-2H3,(H,17,19)(H,15,16,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297347
PNG
(3,3-dimethyl-5-(pyrimidin-4-ylamino)isoindolin-1-o...)
Show SMILES CC1(C)NC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H14N4O/c1-14(2)11-7-9(3-4-10(11)13(19)18-14)17-12-5-6-15-8-16-12/h3-8H,1-2H3,(H,18,19)(H,15,16,17)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297368
PNG
(5-(7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-yla...)
Show SMILES CC1NC(=O)c2ccc(Nc3ncnc4NCCOc34)cc12
Show InChI InChI=1S/C15H15N5O2/c1-8-11-6-9(2-3-10(11)15(21)19-8)20-14-12-13(17-7-18-14)16-4-5-22-12/h2-3,6-8H,4-5H2,1H3,(H,19,21)(H2,16,17,18,20)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297356
PNG
(N-(4-((3-methyl-1-oxoisoindolin-5-yl) amino) pyrid...)
Show SMILES CC1NC(=O)c2ccc(Nc3ccnc(NC(=O)C4CC4)c3)cc12
Show InChI InChI=1S/C18H18N4O2/c1-10-15-8-12(4-5-14(15)18(24)20-10)21-13-6-7-19-16(9-13)22-17(23)11-2-3-11/h4-11H,2-3H2,1H3,(H,20,24)(H2,19,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297370
PNG
(3-(aminomethyl)-3-methyl-5-(pyrimidin-4-ylamino)is...)
Show SMILES CC1(CN)NC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H15N5O/c1-14(7-15)11-6-9(2-3-10(11)13(20)19-14)18-12-4-5-16-8-17-12/h2-6,8H,7,15H2,1H3,(H,19,20)(H,16,17,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297339
PNG
(5-((6-chloropyrimidin-4-yl)amino)isoindolin-1-one ...)
Show SMILES Clc1cc(Nc2ccc3C(=O)NCc3c2)ncn1
Show InChI InChI=1S/C12H9ClN4O/c13-10-4-11(16-6-15-10)17-8-1-2-9-7(3-8)5-14-12(9)18/h1-4,6H,5H2,(H,14,18)(H,15,16,17)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297363
PNG
(4-amino-4-methyl-6-(pyrimidin-4-ylamino)-3,4-dihyd...)
Show SMILES CC1(N)CNC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H15N5O/c1-14(15)7-17-13(20)10-3-2-9(6-11(10)14)19-12-4-5-16-8-18-12/h2-6,8H,7,15H2,1H3,(H,17,20)(H,16,18,19)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297358
PNG
(3-methyl-5-((6-methylpyrimidin-4-yl)amino)isoindol...)
Show SMILES CC1NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc12
Show InChI InChI=1S/C14H18N2O3/c1-8-11-7-9(5-6-10(11)12(17)15-8)16-13(18)19-14(2,3)4/h5-8H,1-4H3,(H,15,17)(H,16,18)
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eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM297353
PNG
(3-methyl-6-(pyrimidin-4-ylamino)-3,4-dihydroquinol...)
Show SMILES CC1Cc2cc(Nc3ccncn3)ccc2NC1=O
Show InChI InChI=1S/C14H14N4O/c1-9-6-10-7-11(2-3-12(10)18-14(9)19)17-13-4-5-15-8-16-13/h2-5,7-9H,6H2,1H3,(H,18,19)(H,15,16,17)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent




US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297370
PNG
(3-(aminomethyl)-3-methyl-5-(pyrimidin-4-ylamino)is...)
Show SMILES CC1(CN)NC(=O)c2ccc(Nc3ccncn3)cc12
Show InChI InChI=1S/C14H15N5O/c1-14(7-15)11-6-9(2-3-10(11)13(20)19-14)18-12-4-5-16-8-17-12/h2-6,8H,7,15H2,1H3,(H,19,20)(H,16,17,18)
PDB
MMDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM297340
PNG
(5-(pyrimidin-4-ylamino)-2,3-dihydro-1H-inden-1-one...)
Show SMILES O=C1CCc2cc(Nc3ccncn3)ccc12
Show InChI InChI=1S/C13H11N3O/c17-12-4-1-9-7-10(2-3-11(9)12)16-13-5-6-14-8-15-13/h2-3,5-8H,1,4H2,(H,14,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US10112955 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%