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Patent code US10117864

Compile Data Set for Download or QSAR
Found 67 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297442
PNG
(4-{[(3-Chloro-6-iodo-2-phenylquinolin-4-yl)carbony...)
Show SMILES OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(Cl)c(nc2ccc(I)cc12)-c1ccccc1
Show InChI InChI=1S/C25H22ClIN2O3/c26-20-19(22(30)29-25-11-8-24(9-12-25,10-13-25)23(31)32)17-14-16(27)6-7-18(17)28-21(20)15-4-2-1-3-5-15/h1-7,14H,8-13H2,(H,29,30)(H,31,32)
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n/an/a 22n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297452
PNG
(5-{[(3-Cyclopropyl-6-iodo-2-phenylquinolin-4-yl)ca...)
Show SMILES OC(=O)C12CCC(CC1)(CCC2)NC(=O)c1c(C2CC2)c(nc2ccc(I)cc12)-c1ccccc1
Show InChI InChI=1S/C29H29IN2O3/c30-20-9-10-22-21(17-20)24(23(18-7-8-18)25(31-22)19-5-2-1-3-6-19)26(33)32-29-12-4-11-28(13-15-29,14-16-29)27(34)35/h1-3,5-6,9-10,17-18H,4,7-8,11-16H2,(H,32,33)(H,34,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297424
PNG
(4-{[(6-Iodo-3-methyl-2-phenylquinolin-4-yl)carbony...)
Show SMILES Cc1c(nc2ccc(I)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25IN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297451
PNG
(5-{[(3-Chloro-6-iodo-2-phenylquinolin-4-yl)carbony...)
Show SMILES OC(=O)C12CCC(CC1)(CCC2)NC(=O)c1c(Cl)c(nc2ccc(I)cc12)-c1ccccc1
Show InChI InChI=1S/C26H24ClIN2O3/c27-21-20(23(31)30-26-10-4-9-25(11-13-26,12-14-26)24(32)33)18-15-17(28)7-8-19(18)29-22(21)16-5-2-1-3-6-16/h1-3,5-8,15H,4,9-14H2,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297439
PNG
(4-{[(6-Bromo-3-cyclopropyl-2-phenylquinolin-4-yl)c...)
Show SMILES OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(C2CC2)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C28H27BrN2O3/c29-19-8-9-21-20(16-19)23(22(17-6-7-17)24(30-21)18-4-2-1-3-5-18)25(32)31-28-13-10-27(11-14-28,12-15-28)26(33)34/h1-5,8-9,16-17H,6-7,10-15H2,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297443
PNG
(4-{[(3-Cyclopropyl-6-iodo-2-phenylquinolin-4-yl)ca...)
Show SMILES OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(C2CC2)c(nc2ccc(I)cc12)-c1ccccc1
Show InChI InChI=1S/C28H27IN2O3/c29-19-8-9-21-20(16-19)23(22(17-6-7-17)24(30-21)18-4-2-1-3-5-18)25(32)31-28-13-10-27(11-14-28,12-15-28)26(33)34/h1-5,8-9,16-17H,6-7,10-15H2,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297440
PNG
(4-{[(6-Bromo-3-chloro-2-phenylquinolin-4-yl)carbon...)
Show SMILES OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(Cl)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C25H22BrClN2O3/c26-16-6-7-18-17(14-16)19(20(27)21(28-18)15-4-2-1-3-5-15)22(30)29-25-11-8-24(9-12-25,10-13-25)23(31)32/h1-7,14H,8-13H2,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297462
PNG
(4-({[6-Bromo-2-(4-bromo-2-thienyl)-3-methylquinoli...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1cc(Br)cs1
Show InChI InChI=1S/C24H22Br2N2O3S/c1-13-19(21(29)28-24-7-4-23(5-8-24,6-9-24)22(30)31)16-10-14(25)2-3-17(16)27-20(13)18-11-15(26)12-32-18/h2-3,10-12H,4-9H2,1H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297411
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297456
PNG
(Sodium 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C([O-])=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)/p-1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297456
PNG
(Sodium 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C([O-])=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)/p-1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297454
PNG
(4-{[(6-Iodo-3-methyl-2-phenylquinolin-4-yl)carbony...)
Show SMILES Cc1c(nc2ccc(I)cc2c1C(=O)NC1C2C3CC(C3)C1C2C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H23IN2O3/c1-12-19(25(30)29-24-20-14-9-15(10-14)21(24)22(20)26(31)32)17-11-16(27)7-8-18(17)28-23(12)13-5-3-2-4-6-13/h2-8,11,14-15,20-22,24H,9-10H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297437
PNG
(4-({[6-Bromo-3-(methylsulfanyl)-2-phenylquinolin-4...)
Show SMILES CSc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3S/c1-33-22-20(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)18-15-17(27)7-8-19(18)28-21(22)16-5-3-2-4-6-16/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297411
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297473
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1=O)(CC2=O)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H21BrN2O5/c1-14-21(17-11-16(27)7-8-18(17)28-22(14)15-5-3-2-4-6-15)23(32)29-26-10-9-25(24(33)34,12-19(26)30)13-20(26)31/h2-8,11H,9-10,12-13H2,1H3,(H,29,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297471
PNG
((-)4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)car...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CC[C@@](CC1)(C(F)C2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H24BrFN2O3/c1-15-21(23(31)30-25-9-11-26(12-10-25,24(32)33)20(28)14-25)18-13-17(27)7-8-19(18)29-22(15)16-5-3-2-4-6-16/h2-8,13,20H,9-12,14H2,1H3,(H,30,31)(H,32,33)/t20?,25?,26-
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297411
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297411
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297411
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297415
PNG
(4-({[6-Bromo-3-methyl-2-(2-thienyl)quinolin-4-yl]c...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1cccs1
Show InChI InChI=1S/C24H23BrN2O3S/c1-14-19(21(28)27-24-9-6-23(7-10-24,8-11-24)22(29)30)16-13-15(25)4-5-17(16)26-20(14)18-3-2-12-31-18/h2-5,12-13H,6-11H2,1H3,(H,27,28)(H,29,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297436
PNG
(4-({[6-Bromo-2-(3-methoxyphenyl)-3-methylquinolin-...)
Show SMILES COc1cccc(c1)-c1nc2ccc(Br)cc2c(C(=O)NC23CCC(CC2)(CC3)C(O)=O)c1C
Show InChI InChI=1S/C27H27BrN2O4/c1-16-22(24(31)30-27-11-8-26(9-12-27,10-13-27)25(32)33)20-15-18(28)6-7-21(20)29-23(16)17-4-3-5-19(14-17)34-2/h3-7,14-15H,8-13H2,1-2H3,(H,30,31)(H,32,33)
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n/an/a 114n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297420
PNG
(4-({[6-Bromo-2-(2-chlorophenyl)-3-methylquinolin-4...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1Cl
Show InChI InChI=1S/C26H24BrClN2O3/c1-15-21(23(31)30-26-11-8-25(9-12-26,10-13-26)24(32)33)18-14-16(27)6-7-20(18)29-22(15)17-4-2-3-5-19(17)28/h2-7,14H,8-13H2,1H3,(H,30,31)(H,32,33)
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n/an/a 128n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297434
PNG
(4-({[6-Bromo-3-methyl-2-(2-methylphenyl)quinolin-4...)
Show SMILES Cc1ccccc1-c1nc2ccc(Br)cc2c(C(=O)NC23CCC(CC2)(CC3)C(O)=O)c1C
Show InChI InChI=1S/C27H27BrN2O3/c1-16-5-3-4-6-19(16)23-17(2)22(20-15-18(28)7-8-21(20)29-23)24(31)30-27-12-9-26(10-13-27,11-14-27)25(32)33/h3-8,15H,9-14H2,1-2H3,(H,30,31)(H,32,33)
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n/an/a 129n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297421
PNG
(4-({[6-Bromo-2-(3-chlorophenyl)-3-methylquinolin-4...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H24BrClN2O3/c1-15-21(23(31)30-26-10-7-25(8-11-26,9-12-26)24(32)33)19-14-17(27)5-6-20(19)29-22(15)16-3-2-4-18(28)13-16/h2-6,13-14H,7-12H2,1H3,(H,30,31)(H,32,33)
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n/an/a 129n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297422
PNG
(4-{[(6-Bromo-3-fluoro-2-phenylquinolin-4-yl)carbon...)
Show SMILES OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(F)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C25H22BrFN2O3/c26-16-6-7-18-17(14-16)19(20(27)21(28-18)15-4-2-1-3-5-15)22(30)29-25-11-8-24(9-12-25,10-13-25)23(31)32/h1-7,14H,8-13H2,(H,29,30)(H,31,32)
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n/an/a 139n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297413
PNG
(4-{[(6,7-Dichloro-3-methyl-2-phenylquinolin-4-yl)c...)
Show SMILES Cc1c(nc2cc(Cl)c(Cl)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H24Cl2N2O3/c1-15-21(23(31)30-26-10-7-25(8-11-26,9-12-26)24(32)33)17-13-18(27)19(28)14-20(17)29-22(15)16-5-3-2-4-6-16/h2-6,13-14H,7-12H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297466
PNG
(4-{[(6-Ethynyl-3-methyl-2-phenylquinolin-4-yl)carb...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)C#C)-c1ccccc1
Show InChI InChI=1S/C28H26N2O3/c1-3-19-9-10-22-21(17-19)23(18(2)24(29-22)20-7-5-4-6-8-20)25(31)30-28-14-11-27(12-15-28,13-16-28)26(32)33/h1,4-10,17H,11-16H2,2H3,(H,30,31)(H,32,33)
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n/an/a 148n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297423
PNG
(4-{[(6-Bromo-3-methoxy-2-phenylquinolin-4-yl)carbo...)
Show SMILES COc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O4/c1-33-22-20(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)18-15-17(27)7-8-19(18)28-21(22)16-5-3-2-4-6-16/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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n/an/a 153n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297455
PNG
(4-{[(6-Bromo-3-chloro-2-phenylquinolin-4-yl)carbon...)
Show SMILES OC(=O)C1C2C3CC(C3)C1C2NC(=O)c1c(Cl)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C25H20BrClN2O3/c26-14-6-7-16-15(10-14)19(21(27)22(28-16)11-4-2-1-3-5-11)24(30)29-23-17-12-8-13(9-12)18(23)20(17)25(31)32/h1-7,10,12-13,17-18,20,23H,8-9H2,(H,29,30)(H,31,32)
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n/an/a 161n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297418
PNG
(4-({[6-Bromo-2-(4-fluorophenyl)-3-methylquinolin-4...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C26H24BrFN2O3/c1-15-21(23(31)30-26-11-8-25(9-12-26,10-13-26)24(32)33)19-14-17(27)4-7-20(19)29-22(15)16-2-5-18(28)6-3-16/h2-7,14H,8-13H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297417
PNG
(4-({[6-Bromo-2-(3-fluorophenyl)-3-methylquinolin-4...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1cccc(F)c1
Show InChI InChI=1S/C26H24BrFN2O3/c1-15-21(23(31)30-26-10-7-25(8-11-26,9-12-26)24(32)33)19-14-17(27)5-6-20(19)29-22(15)16-3-2-4-18(28)13-16/h2-6,13-14H,7-12H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297472
PNG
((+)4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)car...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CC[C@@](CC1)(C(F)C2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H24BrFN2O3/c1-15-21(23(31)30-25-9-11-26(12-10-25,24(32)33)20(28)14-25)18-13-17(27)7-8-19(18)29-22(15)16-5-3-2-4-6-16/h2-8,13,20H,9-12,14H2,1H3,(H,30,31)(H,32,33)/t20?,25?,26-
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297450
PNG
(5-{[(6-Bromo-3-chloro-2-phenylquinolin-4-yl)carbon...)
Show SMILES OC(=O)C12CCC(CC1)(CCC2)NC(=O)c1c(Cl)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C26H24BrClN2O3/c27-17-7-8-19-18(15-17)20(21(28)22(29-19)16-5-2-1-3-6-16)23(31)30-26-10-4-9-25(11-13-26,12-14-26)24(32)33/h1-3,5-8,15H,4,9-14H2,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297470
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(C(F)C2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H24BrFN2O3/c1-15-21(23(31)30-25-9-11-26(12-10-25,24(32)33)20(28)14-25)18-13-17(27)7-8-19(18)29-22(15)16-5-3-2-4-6-16/h2-8,13,20H,9-12,14H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297453
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC1C2C3CC(C3)C1C2C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H23BrN2O3/c1-12-19(25(30)29-24-20-14-9-15(10-14)21(24)22(20)26(31)32)17-11-16(27)7-8-18(17)28-23(12)13-5-3-2-4-6-13/h2-8,11,14-15,20-22,24H,9-10H2,1H3,(H,29,30)(H,31,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297431
PNG
(4-{[(6-Bromo-3,8-dimethyl-2-phenylquinolin-4-yl)ca...)
Show SMILES Cc1cc(Br)cc2c(C(=O)NC34CCC(CC3)(CC4)C(O)=O)c(C)c(nc12)-c1ccccc1
Show InChI InChI=1S/C27H27BrN2O3/c1-16-14-19(28)15-20-21(17(2)23(29-22(16)20)18-6-4-3-5-7-18)24(31)30-27-11-8-26(9-12-27,10-13-27)25(32)33/h3-7,14-15H,8-13H2,1-2H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297427
PNG
(4-({[3-Methyl-2-phenyl-6-(trimethylsilyl)quinolin-...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)[Si](C)(C)C)-c1ccccc1
Show InChI InChI=1S/C29H34N2O3Si/c1-19-24(26(32)31-29-15-12-28(13-16-29,14-17-29)27(33)34)22-18-21(35(2,3)4)10-11-23(22)30-25(19)20-8-6-5-7-9-20/h5-11,18H,12-17H2,1-4H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297438
PNG
(4-{[(6-Bromo-3-ethyl-2-phenylquinolin-4-yl)carbony...)
Show SMILES CCc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C27H27BrN2O3/c1-2-19-22(24(31)30-27-13-10-26(11-14-27,12-15-27)25(32)33)20-16-18(28)8-9-21(20)29-23(19)17-6-4-3-5-7-17/h3-9,16H,2,10-15H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297449
PNG
(5-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CCC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C27H27BrN2O3/c1-17-22(24(31)30-27-11-5-10-26(12-14-27,13-15-27)25(32)33)20-16-19(28)8-9-21(20)29-23(17)18-6-3-2-4-7-18/h2-4,6-9,16H,5,10-15H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297463
PNG
(4-({[6-Bromo-3-methyl-2-(5-methyl-2-thienyl)quinol...)
Show SMILES Cc1ccc(s1)-c1nc2ccc(Br)cc2c(C(=O)NC23CCC(CC2)(CC3)C(O)=O)c1C
Show InChI InChI=1S/C25H25BrN2O3S/c1-14-3-6-19(32-14)21-15(2)20(17-13-16(26)4-5-18(17)27-21)22(29)28-25-10-7-24(8-11-25,9-12-25)23(30)31/h3-6,13H,7-12H2,1-2H3,(H,28,29)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297416
PNG
(4-({[6-Bromo-2-(2-fluorophenyl)-3-methylquinolin-4...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1F
Show InChI InChI=1S/C26H24BrFN2O3/c1-15-21(23(31)30-26-11-8-25(9-12-26,10-13-26)24(32)33)18-14-16(27)6-7-20(18)29-22(15)17-4-2-3-5-19(17)28/h2-7,14H,8-13H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297464
PNG
(4-({[6-Bromo-2-(5-chloro-2-thienyl)-3-methylquinol...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccc(Cl)s1
Show InChI InChI=1S/C24H22BrClN2O3S/c1-13-19(21(29)28-24-9-6-23(7-10-24,8-11-24)22(30)31)15-12-14(25)2-3-16(15)27-20(13)17-4-5-18(26)32-17/h2-5,12H,6-11H2,1H3,(H,28,29)(H,30,31)
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n/an/a 240n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297412
PNG
(4-{[(6-Chloro-3-methyl-2-phenylquinolin-4-yl)carbo...)
Show SMILES Cc1c(nc2ccc(Cl)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25ClN2O3/c1-16-21(23(30)29-26-12-9-25(10-13-26,11-14-26)24(31)32)19-15-18(27)7-8-20(19)28-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,29,30)(H,31,32)
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n/an/a 259n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297433
PNG
(4-{[(3,6,7-Trimethyl-2-phenylquinolin-4-yl carbony...)
Show SMILES Cc1cc2nc(c(C)c(C(=O)NC34CCC(CC3)(CC4)C(O)=O)c2cc1C)-c1ccccc1
Show InChI InChI=1S/C28H30N2O3/c1-17-15-21-22(16-18(17)2)29-24(20-7-5-4-6-8-20)19(3)23(21)25(31)30-28-12-9-27(10-13-28,11-14-28)26(32)33/h4-8,15-16H,9-14H2,1-3H3,(H,30,31)(H,32,33)
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n/an/a 306n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297425
PNG
(4-{[(6-Cyclopropyl-3-methyl-2-phenylquinolin-4-yl)...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)C1CC1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O3/c1-18-24(26(32)31-29-14-11-28(12-15-29,13-16-29)27(33)34)22-17-21(19-7-8-19)9-10-23(22)30-25(18)20-5-3-2-4-6-20/h2-6,9-10,17,19H,7-8,11-16H2,1H3,(H,31,32)(H,33,34)
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n/an/a 326n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297441
PNG
(4-{[(6-Bromo-2-phenyl-3-propylquinolin-4-yl)carbon...)
Show SMILES CCCc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C28H29BrN2O3/c1-2-6-20-23(25(32)31-28-14-11-27(12-15-28,13-16-28)26(33)34)21-17-19(29)9-10-22(21)30-24(20)18-7-4-3-5-8-18/h3-5,7-10,17H,2,6,11-16H2,1H3,(H,31,32)(H,33,34)
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n/an/a 351n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297465
PNG
(4-({[6-Bromo-2-(5-bromo-2-thienyl)-3-methylquinoli...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccc(Br)s1
Show InChI InChI=1S/C24H22Br2N2O3S/c1-13-19(21(29)28-24-9-6-23(7-10-24,8-11-24)22(30)31)15-12-14(25)2-3-16(15)27-20(13)17-4-5-18(26)32-17/h2-5,12H,6-11H2,1H3,(H,28,29)(H,30,31)
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n/an/a 383n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297419
PNG
(4-({[6-Bromo-2-(3,5-difluorophenyl)-3-methylquinol...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H23BrF2N2O3/c1-14-21(23(32)31-26-7-4-25(5-8-26,6-9-26)24(33)34)19-12-16(27)2-3-20(19)30-22(14)15-10-17(28)13-18(29)11-15/h2-3,10-13H,4-9H2,1H3,(H,31,32)(H,33,34)
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n/an/a 386n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297445
PNG
(4-{[(6-Bromo-3-hydroxy-2-phenylquinolin-4-yl)carbo...)
Show SMILES OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(O)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C25H23BrN2O4/c26-16-6-7-18-17(14-16)19(21(29)20(27-18)15-4-2-1-3-5-15)22(30)28-25-11-8-24(9-12-25,10-13-25)23(31)32/h1-7,14,29H,8-13H2,(H,28,30)(H,31,32)
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n/an/a 430n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297469
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(C(O)C2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O4/c1-15-21(23(31)29-25-9-11-26(12-10-25,24(32)33)20(30)14-25)18-13-17(27)7-8-19(18)28-22(15)16-5-3-2-4-6-16/h2-8,13,20,30H,9-12,14H2,1H3,(H,29,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297477
PNG
(4-{[(6-Bromo-2-phenyl-3-vinylquinolin-4-yl)carbony...)
Show SMILES OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(C=C)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C27H25BrN2O3/c1-2-19-22(24(31)30-27-13-10-26(11-14-27,12-15-27)25(32)33)20-16-18(28)8-9-21(20)29-23(19)17-6-4-3-5-7-17/h2-9,16H,1,10-15H2,(H,30,31)(H,32,33)
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n/an/a 440n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297414
PNG
(4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)c...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)C(C)(C)C)-c1ccccc1
Show InChI InChI=1S/C30H34N2O3/c1-19-24(26(33)32-30-15-12-29(13-16-30,14-17-30)27(34)35)22-18-21(28(2,3)4)10-11-23(22)31-25(19)20-8-6-5-7-9-20/h5-11,18H,12-17H2,1-4H3,(H,32,33)(H,34,35)
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n/an/a 456n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297435
PNG
(4-({[6-Bromo-2-(2,6-difluorophenyl)-3-methylquinol...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1c(F)cccc1F
Show InChI InChI=1S/C26H23BrF2N2O3/c1-14-20(23(32)31-26-10-7-25(8-11-26,9-12-26)24(33)34)16-13-15(27)5-6-19(16)30-22(14)21-17(28)3-2-4-18(21)29/h2-6,13H,7-12H2,1H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297444
PNG
(4-({[3-Methyl-2-phenyl-6-(trifluoromethyl)quinolin...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C27H25F3N2O3/c1-16-21(23(33)32-26-12-9-25(10-13-26,11-14-26)24(34)35)19-15-18(27(28,29)30)7-8-20(19)31-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,32,33)(H,34,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297430
PNG
(4-[({3-Methyl-2-phenyl-6-[(trifluoromethyl)sulfany...)
Show SMILES Cc1c(nc2ccc(SC(F)(F)F)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C27H25F3N2O3S/c1-16-21(23(33)32-26-12-9-25(10-13-26,11-14-26)24(34)35)19-15-18(36-27(28,29)30)7-8-20(19)31-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,32,33)(H,34,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297428
PNG
(4-({[6-(Difluoromethyl)-3-methyl-2-phenylquinolin-...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)C(F)F)-c1ccccc1
Show InChI InChI=1S/C27H26F2N2O3/c1-16-21(24(32)31-27-12-9-26(10-13-27,11-14-27)25(33)34)19-15-18(23(28)29)7-8-20(19)30-22(16)17-5-3-2-4-6-17/h2-8,15,23H,9-14H2,1H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297446
PNG
(6-Bromo-N-(4-carbamoylbicyclo[2.2.2]oct-1-yl)-3-me...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(N)=O)-c1ccccc1
Show InChI InChI=1S/C26H26BrN3O2/c1-16-21(23(31)30-26-12-9-25(10-13-26,11-14-26)24(28)32)19-15-18(27)7-8-20(19)29-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H2,28,32)(H,30,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297426
PNG
(4-{[(6-Cyclobutyl-3-methyl-2-phenylquinolin-4-yl)c...)
Show SMILES Cc1c(nc2ccc(cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)C1CCC1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O3/c1-19-25(27(33)32-30-15-12-29(13-16-30,14-17-30)28(34)35)23-18-22(20-8-5-9-20)10-11-24(23)31-26(19)21-6-3-2-4-7-21/h2-4,6-7,10-11,18,20H,5,8-9,12-17H2,1H3,(H,32,33)(H,34,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297467
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(C(O)=O)C(=O)C2)-c1ccccc1
Show InChI InChI=1S/C26H23BrN2O4/c1-15-21(23(31)29-25-9-11-26(12-10-25,24(32)33)20(30)14-25)18-13-17(27)7-8-19(18)28-22(15)16-5-3-2-4-6-16/h2-8,13H,9-12,14H2,1H3,(H,29,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297468
PNG
(4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(C(O)=O)C(F)(F)C2)-c1ccccc1
Show InChI InChI=1S/C26H23BrF2N2O3/c1-15-20(18-13-17(27)7-8-19(18)30-21(15)16-5-3-2-4-6-16)22(32)31-24-9-11-25(12-10-24,23(33)34)26(28,29)14-24/h2-8,13H,9-12,14H2,1H3,(H,31,32)(H,33,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297432
PNG
(4-{[(6,8-Dichloro-3-methyl-2-phenylquinolin-4-yl)c...)
Show SMILES Cc1c(nc2c(Cl)cc(Cl)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H24Cl2N2O3/c1-15-20(23(31)30-26-10-7-25(8-11-26,9-12-26)24(32)33)18-13-17(27)14-19(28)22(18)29-21(15)16-5-3-2-4-6-16/h2-6,13-14H,7-12H2,1H3,(H,30,31)(H,32,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297447
PNG
(3-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbon...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CC(C1)(C2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C23H19BrN2O3/c1-13-18(20(27)26-23-10-22(11-23,12-23)21(28)29)16-9-15(24)7-8-17(16)25-19(13)14-5-3-2-4-6-14/h2-9H,10-12H2,1H3,(H,26,27)(H,28,29)
UniProtKB/SwissProt

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n/an/a 723n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297474
PNG
(4-{[(6-Iodo-3-methyl-2-phenylquinolin-4-yl)carbony...)
Show SMILES Cc1c(nc2ccc(I)cc2c1C(=O)NC12CCC(CC1)(OC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H23IN2O4/c1-15-20(22(29)28-24-9-11-25(12-10-24,23(30)31)32-14-24)18-13-17(26)7-8-19(18)27-21(15)16-5-3-2-4-6-16/h2-8,13H,9-12,14H2,1H3,(H,28,29)(H,30,31)
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n/an/a 762n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297476
PNG
(4-{[(6-Bromo-3-cyano-2-phenylquinolin-4-yl)carbony...)
Show SMILES OC(=O)C12CCC(CC1)(CC2)NC(=O)c1c(C#N)c(nc2ccc(Br)cc12)-c1ccccc1
Show InChI InChI=1S/C26H22BrN3O3/c27-17-6-7-20-18(14-17)21(19(15-28)22(29-20)16-4-2-1-3-5-16)23(31)30-26-11-8-25(9-12-26,10-13-26)24(32)33/h1-7,14H,8-13H2,(H,30,31)(H,32,33)
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n/an/a 762n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297475
PNG
((3-exo,8-anti)-8-{[(6-Bromo-3-methyl-2-phenylquino...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)N[C@H]1[C@H]2CC[C@@H]1C[C@H](C2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H25BrN2O3/c1-14-22(25(30)29-24-16-7-8-17(24)12-18(11-16)26(31)32)20-13-19(27)9-10-21(20)28-23(14)15-5-3-2-4-6-15/h2-6,9-10,13,16-18,24H,7-8,11-12H2,1H3,(H,29,30)(H,31,32)/t16-,17+,18-,24-
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n/an/a 824n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297429
PNG
(4-({[3-Methyl-2-phenyl-6-(trifluoromethoxy)quinoli...)
Show SMILES Cc1c(nc2ccc(OC(F)(F)F)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C27H25F3N2O4/c1-16-21(23(33)32-26-12-9-25(10-13-26,11-14-26)24(34)35)19-15-18(36-27(28,29)30)7-8-20(19)31-22(16)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3,(H,32,33)(H,34,35)
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n/an/a 917n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM297448
PNG
(4-{[(6-Iodo-3-methyl-2-phenylquinolin-4-yl)carbony...)
Show SMILES Cc1c(nc2ccc(I)cc2c1C(=O)NC12CCC(CC1)(C2)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H23IN2O3/c1-15-20(22(29)28-25-11-9-24(14-25,10-12-25)23(30)31)18-13-17(26)7-8-19(18)27-21(15)16-5-3-2-4-6-16/h2-8,13H,9-12,14H2,1H3,(H,28,29)(H,30,31)
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n/an/a 1.28E+3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


US Patent US10117864 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%