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Patent code US10118902

Compile Data Set for Download or QSAR

Found 223 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297502
PNG
(US10118902, Example 4 | {4-[4-(2-azetidin-1-yl-phe...)
Show SMILES CCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1CC1
Show InChI InChI=1S/C28H35N5/c1-3-31(2)22-11-12-25-24(19-22)28(30-27(29-25)21-9-10-21)33-17-13-20(14-18-33)23-7-4-5-8-26(23)32-15-6-16-32/h4-5,7-8,11-12,19-21H,3,6,9-10,13-18H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297520
PNG
(2-{[4-[4-(2-methoxy-phenyl)- piperidin-1-yl]-2-(1-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(C)CC1
Show InChI InChI=1S/C27H34N4O2/c1-27(12-13-27)26-28-23-9-8-20(30(2)16-17-32)18-22(23)25(29-26)31-14-10-19(11-15-31)21-6-4-5-7-24(21)33-3/h4-9,18-19,32H,10-17H2,1-3H3
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297521
PNG
(N-[4-[4-(2-methoxy-phenyl)- piperidin-1-yl]-2-(1-m...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN(C)C)C1(C)CC1
Show InChI InChI=1S/C29H39N5O/c1-29(14-15-29)28-30-25-11-10-22(33(4)19-18-32(2)3)20-24(25)27(31-28)34-16-12-21(13-17-34)23-8-6-7-9-26(23)35-5/h6-11,20-21H,12-19H2,1-5H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297532
PNG
(4-(4-(2-methoxyphenyl)piperidin- 1-yl)-N-methyl-2-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(C)CC1
Show InChI InChI=1S/C31H41N5O2/c1-31(12-13-31)30-32-27-9-8-24(34(2)16-17-35-18-20-38-21-19-35)22-26(27)29(33-30)36-14-10-23(11-15-36)25-6-4-5-7-28(25)37-3/h4-9,22-23H,10-21H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297533
PNG
(N-[4-[4-(2-azetidin-1-yl-phenyl)- piperidin-1-yl]-...)
Show SMILES CN(C)CCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1(C)CC1
Show InChI InChI=1S/C31H42N6/c1-31(14-15-31)30-32-27-11-10-24(35(4)21-20-34(2)3)22-26(27)29(33-30)37-18-12-23(13-19-37)25-8-5-6-9-28(25)36-16-7-17-36/h5-6,8-11,22-23H,7,12-21H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297534
PNG
(US10118902, Example 36 | [4-[4-(2-azetidin-1-yl-ph...)
Show SMILES CN(CCN1CCCC1)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1(C)CC1
Show InChI InChI=1S/C33H44N6/c1-33(14-15-33)32-34-29-11-10-26(36(2)22-23-37-16-5-6-17-37)24-28(29)31(35-32)39-20-12-25(13-21-39)27-8-3-4-9-30(27)38-18-7-19-38/h3-4,8-11,24-25H,5-7,12-23H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297551
PNG
(US10118902, Example 53 | {[4-[4-(2-Dimethylamino-p...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(C)CCCC1
Show InChI InChI=1S/C30H41N5O/c1-30(15-7-8-16-30)29-31-26-12-11-23(34(4)19-20-36)21-25(26)28(32-29)35-17-13-22(14-18-35)24-9-5-6-10-27(24)33(2)3/h5-6,9-12,21-22,36H,7-8,13-20H2,1-4H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297555
PNG
(2-{[4-[4-(2-dimethylamino- phenyl)-piperidin-1-yl]...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(CCCC1)C(F)(F)F
Show InChI InChI=1S/C30H38F3N5O/c1-36(2)26-9-5-4-8-23(26)21-12-16-38(17-13-21)27-24-20-22(37(3)18-19-39)10-11-25(24)34-28(35-27)29(30(31,32)33)14-6-7-15-29/h4-5,8-11,20-21,39H,6-7,12-19H2,1-3H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297557
PNG
(2-({2-(1-fluoro-cyclobutyl)-4-[4- (2-methoxy-pheny...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CCC1
Show InChI InChI=1S/C27H33FN4O2/c1-31(16-17-33)20-8-9-23-22(18-20)25(30-26(29-23)27(28)12-5-13-27)32-14-10-19(11-15-32)21-6-3-4-7-24(21)34-2/h3-4,6-9,18-19,33H,5,10-17H2,1-2H3
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297567
PNG
(US10118902, Example 69 | [4-[4-(2-methoxy-phenyl)-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(C)CCC1
Show InChI InChI=1S/C32H43N5O2/c1-32(13-6-14-32)31-33-28-10-9-25(35(2)17-18-36-19-21-39-22-20-36)23-27(28)30(34-31)37-15-11-24(12-16-37)26-7-4-5-8-29(26)38-3/h4-5,7-10,23-24H,6,11-22H2,1-3H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297595
PNG
(N2-Cyclobutyl-4-[4-(2-methoxy- phenyl)-piperidin-1...)
Show SMILES CCCN(C)c1ccc2nc(NC3CCC3)nc(N3CCC(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C28H37N5O/c1-4-16-32(2)22-12-13-25-24(19-22)27(31-28(30-25)29-21-8-7-9-21)33-17-14-20(15-18-33)23-10-5-6-11-26(23)34-3/h5-6,10-13,19-21H,4,7-9,14-18H2,1-3H3,(H,29,30,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297600
PNG
(1-[2-cyclopropyl-6-(methyl- propyl-amino)-quinazol...)
Show SMILES CCCN(C)c1ccc2nc(nc(N3CCC(CC3=O)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C27H32N4O2/c1-4-14-30(2)20-11-12-23-22(17-20)27(29-26(28-23)18-9-10-18)31-15-13-19(16-25(31)32)21-7-5-6-8-24(21)33-3/h5-8,11-12,17-19H,4,9-10,13-16H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297657
PNG
(2-{2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperidi...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc(C)c1CC(=O)N(C)CCO)C1CC1
Show InChI InChI=1S/C25H34N4O3/c1-17-21(16-23(31)28(2)14-15-30)25(27-24(26-17)19-8-9-19)29-12-10-18(11-13-29)20-6-4-5-7-22(20)32-3/h4-7,18-19,30H,8-16H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297658
PNG
(2-{2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperidi...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc(C)c1CC(=O)Nc1ccccc1)C1CC1
Show InChI InChI=1S/C28H32N4O2/c1-19-24(18-26(33)30-22-8-4-3-5-9-22)28(31-27(29-19)21-12-13-21)32-16-14-20(15-17-32)23-10-6-7-11-25(23)34-2/h3-11,20-21H,12-18H2,1-2H3,(H,30,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297662
PNG
(2-{2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperidi...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(ncc1CC(=O)N(C)CCO)C1CC1
Show InChI InChI=1S/C24H32N4O3/c1-27(13-14-29)22(30)15-19-16-25-23(18-7-8-18)26-24(19)28-11-9-17(10-12-28)20-5-3-4-6-21(20)31-2/h3-6,16-18,29H,7-15H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297670
PNG
(US10118902, Example 172 | {7-Chloro-6-[(2-hydroxy-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2cc(Cl)c(cc12)N(C)CCO)C1(F)CC1
Show InChI InChI=1S/C26H30ClFN4O2/c1-31(13-14-33)22-15-19-21(16-20(22)27)29-25(26(28)9-10-26)30-24(19)32-11-7-17(8-12-32)18-5-3-4-6-23(18)34-2/h3-6,15-17,33H,7-14H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297582
PNG
((S)-2-cyclopropyl-4-(4-(2- methoxyphenyl)piperidin...)
Show SMILES CO[C@H]1CCN(C1)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C28H34N4O2/c1-33-22-13-16-32(18-22)21-9-10-25-24(17-21)28(30-27(29-25)20-7-8-20)31-14-11-19(12-15-31)23-5-3-4-6-26(23)34-2/h3-6,9-10,17,19-20,22H,7-8,11-16,18H2,1-2H3/t22-/m0/s1
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297677
PNG
(({2-Cyclopropyl-4-[4-(2-methoxy- phenyl)-piperidin...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CC(O)=O)C1CC1
Show InChI InChI=1S/C26H30N4O3/c1-29(16-24(31)32)19-9-10-22-21(15-19)26(28-25(27-22)18-7-8-18)30-13-11-17(12-14-30)20-5-3-4-6-23(20)33-2/h3-6,9-10,15,17-18H,7-8,11-14,16H2,1-2H3,(H,31,32)
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297678
PNG
(2-((2-(1-fluorocyclopropyl)-4-(4- (2-methoxyphenyl...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CC(O)=O)C1(F)CC1
Show InChI InChI=1S/C26H29FN4O3/c1-30(16-23(32)33)18-7-8-21-20(15-18)24(29-25(28-21)26(27)11-12-26)31-13-9-17(10-14-31)19-5-3-4-6-22(19)34-2/h3-8,15,17H,9-14,16H2,1-2H3,(H,32,33)
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297681
PNG
(3-{8-Chloro-2-(1-fluoro- cyclobutyl)-4-[4-(2-metho...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2c(Cl)cc(cc12)N1CC[C@H](O)C1)C1(F)CCC1
Show InChI InChI=1S/C28H32ClFN4O2/c1-36-24-6-3-2-5-21(24)18-7-12-33(13-8-18)26-22-15-19(34-14-9-20(35)17-34)16-23(29)25(22)31-27(32-26)28(30)10-4-11-28/h2-3,5-6,15-16,18,20,35H,4,7-14,17H2,1H3/t20-/m0/s1
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297687
PNG
(2-({2-(1-Fluoro-cyclopropyl)-4- [4-(2-methoxy-cycl...)
Show SMILES COC1CCCCC1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1
Show InChI InChI=1S/C26H37FN4O2/c1-30(15-16-32)19-7-8-22-21(17-19)24(29-25(28-22)26(27)11-12-26)31-13-9-18(10-14-31)20-5-3-4-6-23(20)33-2/h7-8,17-18,20,23,32H,3-6,9-16H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297632
PNG
(2-cyclopropyl-4-(4-(2- methoxyphenyl)piperidin-1- ...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2cnc(cc12)N(C)CCN1CCOCC1)C1CC1
Show InChI InChI=1S/C29H38N6O2/c1-33(13-14-34-15-17-37-18-16-34)27-19-24-25(20-30-27)31-28(22-7-8-22)32-29(24)35-11-9-21(10-12-35)23-5-3-4-6-26(23)36-2/h3-6,19-22H,7-18H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297700
PNG
(1-{8-Chloro-2-(1-fluoro- cyclopropyl)-4-[4-(2-meth...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2c(Cl)cc(cc12)N1CC[C@H](O)C1)C1(F)CC1
Show InChI InChI=1S/C27H30ClFN4O2/c1-35-23-5-3-2-4-20(23)17-6-11-32(12-7-17)25-21-14-18(33-13-8-19(34)16-33)15-22(28)24(21)30-26(31-25)27(29)9-10-27/h2-5,14-15,17,19,34H,6-13,16H2,1H3/t19-/m0/s1
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297504
PNG
(2-({4-[4-(2-azetidin-1-yl-phenyl)- piperidin-1-yl]...)
Show SMILES CN(CCO)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1CC1
Show InChI InChI=1S/C28H35N5O/c1-31(17-18-34)22-9-10-25-24(19-22)28(30-27(29-25)21-7-8-21)33-15-11-20(12-16-33)23-5-2-3-6-26(23)32-13-4-14-32/h2-3,5-6,9-10,19-21,34H,4,7-8,11-18H2,1H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297517
PNG
(US10118902, Example 19 | {2-(1-dimethylamino- cycl...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)C)C1(CC1)N(C)C
Show InChI InChI=1S/C27H35N5O/c1-30(2)20-10-11-23-22(18-20)25(29-26(28-23)27(14-15-27)31(3)4)32-16-12-19(13-17-32)21-8-6-7-9-24(21)33-5/h6-11,18-19H,12-17H2,1-5H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297524
PNG
(US10118902, Example 26 | [4-[4-(2-dimethylamino-ph...)
Show SMILES COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N(C)C)c2c1)C1(C)CC1
Show InChI InChI=1S/C29H39N5O/c1-29(14-15-29)28-30-25-11-10-22(33(4)18-19-35-5)20-24(25)27(31-28)34-16-12-21(13-17-34)23-8-6-7-9-26(23)32(2)3/h6-11,20-21H,12-19H2,1-5H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297535
PNG
(US10118902, Example 37 | {2-cyclopentyl-4-[4-(2-me...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)C)C1CCCC1
Show InChI InChI=1S/C27H34N4O/c1-30(2)21-12-13-24-23(18-21)27(29-26(28-24)20-8-4-5-9-20)31-16-14-19(15-17-31)22-10-6-7-11-25(22)32-3/h6-7,10-13,18-20H,4-5,8-9,14-17H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297536
PNG
(2-({2-cyclopentyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1CCCC1
Show InChI InChI=1S/C28H36N4O2/c1-31(17-18-33)22-11-12-25-24(19-22)28(30-27(29-25)21-7-3-4-8-21)32-15-13-20(14-16-32)23-9-5-6-10-26(23)34-2/h5-6,9-12,19-21,33H,3-4,7-8,13-18H2,1-2H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297540
PNG
(US10118902, Example 42 | {2-cyclobutyl-4-[4-(2-met...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)C)C1CCC1
Show InChI InChI=1S/C26H32N4O/c1-29(2)20-11-12-23-22(17-20)26(28-25(27-23)19-7-6-8-19)30-15-13-18(14-16-30)21-9-4-5-10-24(21)31-3/h4-5,9-12,17-19H,6-8,13-16H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297547
PNG
(2-{[4-[4-(2-dimethylamino- phenyl)-piperidin-1-yl]...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(CC1)C(F)(F)F
Show InChI InChI=1S/C28H34F3N5O/c1-34(2)24-7-5-4-6-21(24)19-10-14-36(15-11-19)25-22-18-20(35(3)16-17-37)8-9-23(22)32-26(33-25)27(12-13-27)28(29,30)31/h4-9,18-19,37H,10-17H2,1-3H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297549
PNG
(2-{[4-[4-(2-methoxy-phenyl)- piperidin-1-yl]-2-(1-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(C)CCCC1
Show InChI InChI=1S/C29H38N4O2/c1-29(14-6-7-15-29)28-30-25-11-10-22(32(2)18-19-34)20-24(25)27(31-28)33-16-12-21(13-17-33)23-8-4-5-9-26(23)35-3/h4-5,8-11,20-21,34H,6-7,12-19H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297558
PNG
(US10118902, Example 60 | {2-(1-fluoro-cyclobutyl)-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(F)CCC1
Show InChI InChI=1S/C31H40FN5O2/c1-35(16-17-36-18-20-39-21-19-36)24-8-9-27-26(22-24)29(34-30(33-27)31(32)12-5-13-31)37-14-10-23(11-15-37)25-6-3-4-7-28(25)38-2/h3-4,6-9,22-23H,5,10-21H2,1-2H3
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297562
PNG
(US10118902, Example 64 | [4-[4-(2-methoxy-phenyl)-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(CCC1)C(F)(F)F
Show InChI InChI=1S/C32H40F3N5O2/c1-38(16-17-39-18-20-42-21-19-39)24-8-9-27-26(22-24)29(37-30(36-27)31(12-5-13-31)32(33,34)35)40-14-10-23(11-15-40)25-6-3-4-7-28(25)41-2/h3-4,6-9,22-23H,5,10-21H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297568
PNG
(2-{[4-[4-(2-Methoxy-phenyl)- piperidin-1-yl]-2-(1-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(C)CCC1
Show InChI InChI=1S/C28H36N4O2/c1-28(13-6-14-28)27-29-24-10-9-21(31(2)17-18-33)19-23(24)26(30-27)32-15-11-20(12-16-32)22-7-4-5-8-25(22)34-3/h4-5,7-10,19-20,33H,6,11-18H2,1-3H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297571
PNG
(US10118902, Example 73 | [4-[4-(2-dimethylamino-ph...)
Show SMILES CN(C)c1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)C1(F)CCCC1
Show InChI InChI=1S/C33H45FN6O/c1-37(2)30-9-5-4-8-27(30)25-12-16-40(17-13-25)31-28-24-26(38(3)18-19-39-20-22-41-23-21-39)10-11-29(28)35-32(36-31)33(34)14-6-7-15-33/h4-5,8-11,24-25H,6-7,12-23H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297576
PNG
((1-{2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N1CCC(CC1)N(C)C)C1CC1
Show InChI InChI=1S/C30H39N5O/c1-33(2)23-14-18-34(19-15-23)24-10-11-27-26(20-24)30(32-29(31-27)22-8-9-22)35-16-12-21(13-17-35)25-6-4-5-7-28(25)36-3/h4-7,10-11,20-23H,8-9,12-19H2,1-3H3
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297579
PNG
((R)-1-{2-cyclopropyl-4-[4-(2- methoxy-phenyl)-pipe...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N1CC[C@@H](O)C1)C1CC1
Show InChI InChI=1S/C27H32N4O2/c1-33-25-5-3-2-4-22(25)18-10-13-30(14-11-18)27-23-16-20(31-15-12-21(32)17-31)8-9-24(23)28-26(29-27)19-6-7-19/h2-5,8-9,16,18-19,21,32H,6-7,10-15,17H2,1H3/t21-/m1/s1
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SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297587
PNG
(2-({2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(CN(C)CCO)cc12)C1CC1
Show InChI InChI=1S/C27H34N4O2/c1-30(15-16-32)18-19-7-10-24-23(17-19)27(29-26(28-24)21-8-9-21)31-13-11-20(12-14-31)22-5-3-4-6-25(22)33-2/h3-7,10,17,20-21,32H,8-9,11-16,18H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297588
PNG
(({2-cyclopropyl-4-[4-(2-methoxy- phenyl)-piperidin...)
Show SMILES CCOC(=O)CN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Show InChI InChI=1S/C28H34N4O3/c1-4-35-26(33)18-31(2)21-11-12-24-23(17-21)28(30-27(29-24)20-9-10-20)32-15-13-19(14-16-32)22-7-5-6-8-25(22)34-3/h5-8,11-12,17,19-20H,4,9-10,13-16,18H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297603
PNG
(US10118902, Example 105 | {2-cyclopropyl-7-fluoro-...)
Show SMILES CCCN(C)c1cc2c(nc(nc2cc1F)C1CC1)N1CCC(CC1)c1ccccc1OC
Show InChI InChI=1S/C27H33FN4O/c1-4-13-31(2)24-16-21-23(17-22(24)28)29-26(19-9-10-19)30-27(21)32-14-11-18(12-15-32)20-7-5-6-8-25(20)33-3/h5-8,16-19H,4,9-15H2,1-3H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297606
PNG
(2-({2-cyclopropyl-4-[4-(4-fluoro- 2-methoxy-phenyl...)
Show SMILES COc1cc(F)ccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C26H31FN4O2/c1-30(13-14-32)20-6-8-23-22(16-20)26(29-25(28-23)18-3-4-18)31-11-9-17(10-12-31)21-7-5-19(27)15-24(21)33-2/h5-8,15-18,32H,3-4,9-14H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297610
PNG
(2-({7-chloro-2-cyclopropyl-4-[4- (4-fluoro-2-metho...)
Show SMILES COc1cc(F)ccc1C1CCN(CC1)c1nc(nc2cc(Cl)c(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C26H30ClFN4O2/c1-31(11-12-33)23-14-20-22(15-21(23)27)29-25(17-3-4-17)30-26(20)32-9-7-16(8-10-32)19-6-5-18(28)13-24(19)34-2/h5-6,13-17,33H,3-4,7-12H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297615
PNG
(2-({2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2cc(C)c(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C27H34N4O2/c1-18-16-23-22(17-24(18)30(2)14-15-32)27(29-26(28-23)20-8-9-20)31-12-10-19(11-13-31)21-6-4-5-7-25(21)33-3/h4-7,16-17,19-20,32H,8-15H2,1-3H3
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297617
PNG
(2-({4-[4-(2-azetidin-1-yl-phenyl)- piperidin-1-yl]...)
Show SMILES CN(CCO)c1cc2c(nc(nc2cc1Cl)C1CC1)N1CCC(CC1)c1ccccc1N1CCC1
Show InChI InChI=1S/C28H34ClN5O/c1-32(15-16-35)26-17-22-24(18-23(26)29)30-27(20-7-8-20)31-28(22)34-13-9-19(10-14-34)21-5-2-3-6-25(21)33-11-4-12-33/h2-3,5-6,17-20,35H,4,7-16H2,1H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297620
PNG
(US10118902, Example 122 | {2-cyclopropyl-4-[4-(2-m...)
Show SMILES CCCN(C)c1cc2c(nc(nc2cc1C)C1CC1)N1CCC(CC1)c1ccccc1OC
Show InChI InChI=1S/C28H36N4O/c1-5-14-31(3)25-18-23-24(17-19(25)2)29-27(21-10-11-21)30-28(23)32-15-12-20(13-16-32)22-8-6-7-9-26(22)33-4/h6-9,17-18,20-21H,5,10-16H2,1-4H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297635
PNG
(2-({2-cyclopropyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2cnc(cc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C25H31N5O2/c1-29(13-14-31)23-15-20-21(16-26-23)27-24(18-7-8-18)28-25(20)30-11-9-17(10-12-30)19-5-3-4-6-22(19)32-2/h3-6,15-18,31H,7-14H2,1-2H3
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n/an/an/an/a<500n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297645
PNG
(US10118902, Example 147 | {4-[4-(2-methoxy-phenyl)...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCN1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C33H39N5O2/c1-36(18-19-37-20-22-40-23-21-37)27-12-13-30-29(24-27)33(35-32(34-30)26-8-4-3-5-9-26)38-16-14-25(15-17-38)28-10-6-7-11-31(28)39-2/h3-13,24-25H,14-23H2,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297660
PNG
(2-{4-cyclopropyl-2-[4-(2- methoxy-phenyl)-piperidi...)
Show SMILES CCCN(C)C(=O)Cc1c(C)nc(nc1C1CC1)N1CCC(CC1)c1ccccc1OC
Show InChI InChI=1S/C26H36N4O2/c1-5-14-29(3)24(31)17-22-18(2)27-26(28-25(22)20-10-11-20)30-15-12-19(13-16-30)21-8-6-7-9-23(21)32-4/h6-9,19-20H,5,10-17H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297630
PNG
(2-((2-cyclopropyl-5-fluoro-4-(4- (2-methoxyphenyl)...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(N(C)CCO)c(F)c12)C1CC1
Show InChI InChI=1S/C26H31FN4O2/c1-30(15-16-32)21-10-9-20-23(24(21)27)26(29-25(28-20)18-7-8-18)31-13-11-17(12-14-31)19-5-3-4-6-22(19)33-2/h3-6,9-10,17-18,32H,7-8,11-16H2,1-2H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens)
BDBM297667
PNG
(2-({2-Cyclopropyl-4-[4-(2- methoxy-phenyl)-piperid...)
Show SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2cc(ccc12)N(C)CCO)C1CC1
Show InChI InChI=1S/C26H32N4O2/c1-29(15-16-31)20-9-10-22-23(17-20)27-25(19-7-8-19)28-26(22)30-13-11-18(12-14-30)21-5-3-4-6-24(21)32-2/h3-6,9-10,17-19,31H,7-8,11-16H2,1-2H3
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n/an/an/an/a 6.00E+3n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%