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Patent code US10124003

Compile Data Set for Download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161438
PNG
(US10124003, Ex. Compound 51 | US9108973, 51)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CN(C2CN(C2)C(=O)C=C)C2N=CN=C(N)C12
Show InChI InChI=1S/C22H23N5O3/c1-4-19(28)26-11-16(12-26)27-10-15(20-21(23)24-13-25-22(20)27)6-5-14-7-17(29-2)9-18(8-14)30-3/h4,7-10,13,16,20,22H,1,11-12H2,2-3H3,(H2,23,24,25)
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US Patent
n/an/a<0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161453
PNG
(US10124003, Ex. Compound 66 | US9108973, 66)
Show SMILES COC(=O)[C@@H]1C[C@@H](CN1C(=O)C=C)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H25N5O5/c1-5-21(31)30-13-17(10-20(30)25(32)35-4)29-12-16(22-23(26)27-14-28-24(22)29)7-6-15-8-18(33-2)11-19(9-15)34-3/h5,8-9,11-12,14,17,20H,1,10,13H2,2-4H3,(H2,26,27,28)/t17-,20-/m0/s1
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n/an/a<0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161426
PNG
(US10124003, Ex. Compound 39 | US9108973, 39 | US91...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C23H23N5O3/c1-4-20(29)27-8-7-17(13-27)28-12-16(21-22(24)25-14-26-23(21)28)6-5-15-9-18(30-2)11-19(10-15)31-3/h4,9-12,14,17H,1,7-8,13H2,2-3H3,(H2,24,25,26)/t17-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161419
PNG
(US10124003, Ex. Compound 32 | US9108973, 32)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161440
PNG
(US10124003, Ex. Compound 53 | US9108973, 53)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O3/c1-35-22-12-19(13-23(14-22)36-2)7-8-20-15-33(27-25(20)26(28)29-18-30-27)21-16-32(17-21)24(34)6-5-11-31-9-3-4-10-31/h5-6,12-15,18,21H,3-4,9-11,16-17H2,1-2H3,(H2,28,29,30)/b6-5+
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161450
PNG
(US10124003, Ex. Compound 63 | US9108973, 63)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](O)C2)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O4/c1-36-22-10-18(11-23(12-22)37-2)5-6-19-13-33(27-25(19)26(28)29-17-30-27)20-14-32(15-20)24(35)4-3-8-31-9-7-21(34)16-31/h3-4,10-13,17,20-21,34H,7-9,14-16H2,1-2H3,(H2,28,29,30)/b4-3+/t21-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161439
PNG
(US10124003, Ex. Compound 52 | US9108973, 52 | US91...)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H28N6O3/c1-29(2)9-5-6-22(32)30-14-19(15-30)31-13-18(23-24(26)27-16-28-25(23)31)8-7-17-10-20(33-3)12-21(11-17)34-4/h5-6,10-13,16,19H,9,14-15H2,1-4H3,(H2,26,27,28)/b6-5+
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161396
PNG
(US10124003, Ex. Compound 9 | US9108973, 9)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 1.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161392
PNG
(US10124003, Ex. Compound 5 | US9108973, 5)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1S/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US9108973, 2)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161446
PNG
(US10124003, Ex. Compound 59 | US9108973, 59)
Show SMILES CCN(CC)C\C=C\C(=O)N1CC(C1)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H32N6O3/c1-5-31(6-2)11-7-8-24(34)32-16-21(17-32)33-15-20(25-26(28)29-18-30-27(25)33)10-9-19-12-22(35-3)14-23(13-19)36-4/h7-8,12-15,18,21H,5-6,11,16-17H2,1-4H3,(H2,28,29,30)/b8-7+
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298387
PNG
(US10124003, Ex. Compound 68)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@@H]2C[C@@H](N(C2)C(=O)C=C)c2nnco2)c2ncnc(N)c12
Show InChI InChI=1S/C25H23N7O4/c1-4-21(33)32-12-17(9-20(32)25-30-29-14-36-25)31-11-16(22-23(26)27-13-28-24(22)31)6-5-15-7-18(34-2)10-19(8-15)35-3/h4,7-8,10-11,13-14,17,20H,1,9,12H2,2-3H3,(H2,26,27,28)/t17-,20-/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161397
PNG
(US10124003, Ex. Compound 10 | US9108973, 10)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C#CCO)c2ncnc(N)c12
Show InChI InChI=1S/C22H20N6O4/c1-31-16-8-14(9-17(10-16)32-2)5-6-18-20-21(23)24-13-25-22(20)28(26-18)15-11-27(12-15)19(30)4-3-7-29/h8-10,13,15,29H,7,11-12H2,1-2H3,(H2,23,24,25)
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n/an/a 1.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161444
PNG
(US10124003, Ex. Compound 57 | US9108973, 57)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H30N6O3/c1-17(2)28-9-5-6-23(33)31-14-20(15-31)32-13-19(24-25(27)29-16-30-26(24)32)8-7-18-10-21(34-3)12-22(11-18)35-4/h5-6,10-13,16-17,20,28H,9,14-15H2,1-4H3,(H2,27,29,30)/b6-5+
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161447
PNG
(US10124003, Ex. Compound 60 | US9108973, 60)
Show SMILES COCCN(C)C\C=C\C(=O)N1CC(C1)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C27H32N6O4/c1-31(10-11-35-2)9-5-6-24(34)32-16-21(17-32)33-15-20(25-26(28)29-18-30-27(25)33)8-7-19-12-22(36-3)14-23(13-19)37-4/h5-6,12-15,18,21H,9-11,16-17H2,1-4H3,(H2,28,29,30)/b6-5+
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298378
PNG
(US10124003, Ex. Compound 56)
Show SMILES CCN(C)C\C=C\C(=O)N1CC(C1)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H30N6O3/c1-5-30(2)10-6-7-23(33)31-15-20(16-31)32-14-19(24-25(27)28-17-29-26(24)32)9-8-18-11-21(34-3)13-22(12-18)35-4/h6-7,11-14,17,20H,5,10,15-16H2,1-4H3,(H2,27,28,29)/b7-6+
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298370
PNG
(US10124003, Ex. Compound 47)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CN([C@H]2CCN(C2)C(=O)C#CC(C)(C)O)C2N=CN=C(N)C12
Show InChI InChI=1S/C26H29N5O4/c1-26(2,33)9-7-22(32)30-10-8-19(15-30)31-14-18(23-24(27)28-16-29-25(23)31)6-5-17-11-20(34-3)13-21(12-17)35-4/h11-14,16,19,23,25,33H,8,10,15H2,1-4H3,(H2,27,28,29)/t19-,23?,25?/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161399
PNG
(US10124003, Ex. Compound 12 | US9108973, 12)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C24H27N7O3/c1-29(2)9-5-6-21(32)30-13-17(14-30)31-24-22(23(25)26-15-27-24)20(28-31)8-7-16-10-18(33-3)12-19(11-16)34-4/h5-6,10-12,15,17H,9,13-14H2,1-4H3,(H2,25,26,27)/b6-5+
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n/an/a 2.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161448
PNG
(US10124003, Ex. Compound 61 | US9108973, 61)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CCC(O)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C28H32N6O4/c1-37-23-12-19(13-24(14-23)38-2)5-6-20-15-34(28-26(20)27(29)30-18-31-28)21-16-33(17-21)25(36)4-3-9-32-10-7-22(35)8-11-32/h3-4,12-15,18,21-22,35H,7-11,16-17H2,1-2H3,(H2,29,30,31)/b4-3+
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n/an/a 2.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161388
PNG
(US10124003, Ex. Compound 1 | US9108973, 1)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)
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n/an/a 2.40n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298377
PNG
(US10124003, Ex. Compound 55)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN2CCC2)c2ncnc(N)c12
Show InChI InChI=1S/C26H28N6O3/c1-34-21-11-18(12-22(13-21)35-2)6-7-19-14-32(26-24(19)25(27)28-17-29-26)20-15-31(16-20)23(33)5-3-8-30-9-4-10-30/h3,5,11-14,17,20H,4,8-10,15-16H2,1-2H3,(H2,27,28,29)/b5-3+
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n/an/a 2.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161406
PNG
(US10124003, Ex. Compound 19 | US9108973, 19)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN(C)C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H31N7O3/c1-17(2)31(3)10-6-7-23(34)32-14-19(15-32)33-26-24(25(27)28-16-29-26)22(30-33)9-8-18-11-20(35-4)13-21(12-18)36-5/h6-7,11-13,16-17,19H,10,14-15H2,1-5H3,(H2,27,28,29)/b7-6+
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n/an/a 2.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161402
PNG
(US10124003, Ex. Compound 15 | US9108973, 15)
Show SMILES CCN(C)C\C=C\C(=O)N1CC(C1)n1nc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H29N7O3/c1-5-30(2)10-6-7-22(33)31-14-18(15-31)32-25-23(24(26)27-16-28-25)21(29-32)9-8-17-11-19(34-3)13-20(12-17)35-4/h6-7,11-13,16,18H,5,10,14-15H2,1-4H3,(H2,26,27,28)/b7-6+
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n/an/a 3n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161427
PNG
(US10124003, Ex. Compound 40 | US9108973, 40)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C28H32N6O3/c1-36-23-14-20(15-24(16-23)37-2)7-8-21-17-34(28-26(21)27(29)30-19-31-28)22-9-13-33(18-22)25(35)6-5-12-32-10-3-4-11-32/h5-6,14-17,19,22H,3-4,9-13,18H2,1-2H3,(H2,29,30,31)/b6-5+/t22-/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298358
PNG
(US10124003, Ex. Compound 20)
Show SMILES COc1cc(OC)cc(c1)C#CC1NN(C2CN(C2)C(=O)\C=C\CN2CCCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C27H33N7O3/c1-36-21-13-19(14-22(15-21)37-2)8-9-23-25-26(28)29-18-30-27(25)34(31-23)20-16-33(17-20)24(35)7-6-12-32-10-4-3-5-11-32/h6-7,13-15,18,20,23,31H,3-5,10-12,16-17H2,1-2H3,(H2,28,29,30)/b7-6+
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n/an/a 3.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298362
PNG
(US10124003, Ex. Compound 28)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](CO)N(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C23H24N6O4/c1-4-20(31)28-11-15(9-16(28)12-30)29-23-21(22(24)25-13-26-23)19(27-29)6-5-14-7-17(32-2)10-18(8-14)33-3/h4,7-8,10,13,15-16,30H,1,9,11-12H2,2-3H3,(H2,24,25,26)/t15-,16-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298354
PNG
(US10124003, Ex. Compound 16)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(O)\C=C\CNC2CCC2)c2ncnc(N)c12
Show InChI InChI=1S/C26H31N7O3/c1-35-20-11-17(12-21(13-20)36-2)8-9-22-24-25(27)29-16-30-26(24)33(31-22)19-14-32(15-19)23(34)7-4-10-28-18-5-3-6-18/h4,7,11-13,16,18-19,23,28,34H,3,5-6,10,14-15H2,1-2H3,(H2,27,29,30)/b7-4+
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n/an/a 3.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161401
PNG
(US10124003, Ex. Compound 14 | US9108973, 14)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C25H29N7O3/c1-16(2)27-9-5-6-22(33)31-13-18(14-31)32-25-23(24(26)28-15-29-25)21(30-32)8-7-17-10-19(34-3)12-20(11-17)35-4/h5-6,10-12,15-16,18,27H,9,13-14H2,1-4H3,(H2,26,28,29)/b6-5+
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n/an/a 3.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161404
PNG
(US10124003, Ex. Compound 17 | US9108973, 17)
Show SMILES CCN(CC)C\C=C\C(=O)N1CC(C1)n1nc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1S/C26H31N7O3/c1-5-31(6-2)11-7-8-23(34)32-15-19(16-32)33-26-24(25(27)28-17-29-26)22(30-33)10-9-18-12-20(35-3)14-21(13-18)36-4/h7-8,12-14,17,19H,5-6,11,15-16H2,1-4H3,(H2,27,28,29)/b8-7+
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n/an/a 4.10n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161433
PNG
(US10124003, Ex. Compound 46 | US9108973, 46)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC)c2ncnc(N)c12
Show InChI InChI=1S/C24H23N5O3/c1-4-5-21(30)28-9-8-18(14-28)29-13-17(22-23(25)26-15-27-24(22)29)7-6-16-10-19(31-2)12-20(11-16)32-3/h10-13,15,18H,8-9,14H2,1-3H3,(H2,25,26,27)/t18-/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161405
PNG
(US10124003, Ex. Compound 18 | US9108973, 18)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H31N7O3/c1-26(2,3)30-10-6-7-22(34)32-14-18(15-32)33-25-23(24(27)28-16-29-25)21(31-33)9-8-17-11-19(35-4)13-20(12-17)36-5/h6-7,11-13,16,18,30H,10,14-15H2,1-5H3,(H2,27,28,29)/b7-6+
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n/an/a 4.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298365
PNG
(US10124003, Ex. Compound 38)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H30N6O3/c1-30(2)10-5-6-23(33)31-11-9-20(16-31)32-15-19(24-25(27)28-17-29-26(24)32)8-7-18-12-21(34-3)14-22(13-18)35-4/h5-6,12-15,17,20H,9-11,16H2,1-4H3,(H2,27,28,29)/b6-5+/t20-/m0/s1
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n/an/a 4.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298389
PNG
(US10124003, Ex. Compound 73)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C=C)c2ccnc(N)c12
Show InChI InChI=1S/C24H24N4O3/c1-4-22(29)27-10-8-18(15-27)28-14-17(23-21(28)7-9-26-24(23)25)6-5-16-11-19(30-2)13-20(12-16)31-3/h4,7,9,11-14,18H,1,8,10,15H2,2-3H3,(H2,25,26)/t18-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161410
PNG
(US10124003, Ex. Compound 23 | US9108973, 23)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](F)C2)c2ncnc(N)c12
Show InChI InChI=1S/C26H28FN7O3/c1-36-20-10-17(11-21(12-20)37-2)5-6-22-24-25(28)29-16-30-26(24)34(31-22)19-14-33(15-19)23(35)4-3-8-32-9-7-18(27)13-32/h3-4,10-12,16,18-19H,7-9,13-15H2,1-2H3,(H2,28,29,30)/b4-3+/t18-/m1/s1
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n/an/a 5.60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161437
PNG
(US10124003, Ex. Compound 50 | US9108973, 50)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CCCCC2)c2ncnc(N)c12
Show InChI InChI=1S/C29H34N6O3/c1-37-24-15-21(16-25(17-24)38-2)8-9-22-18-35(29-27(22)28(30)31-20-32-29)23-10-14-34(19-23)26(36)7-6-13-33-11-4-3-5-12-33/h6-7,15-18,20,23H,3-5,10-14,19H2,1-2H3,(H2,30,31,32)/b7-6+/t23-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161429
PNG
(US10124003, Ex. Compound 42 | US9108973, 42)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CCC(O)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C29H34N6O4/c1-38-24-14-20(15-25(16-24)39-2)5-6-21-17-35(29-27(21)28(30)31-19-32-29)22-7-13-34(18-22)26(37)4-3-10-33-11-8-23(36)9-12-33/h3-4,14-17,19,22-23,36H,7-13,18H2,1-2H3,(H2,30,31,32)/b4-3+/t22-/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161410
PNG
(US10124003, Ex. Compound 23 | US9108973, 23)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CC[C@@H](F)C2)c2ncnc(N)c12
Show InChI InChI=1S/C26H28FN7O3/c1-36-20-10-17(11-21(12-20)37-2)5-6-22-24-25(28)29-16-30-26(24)34(31-22)19-14-33(15-19)23(35)4-3-8-32-9-7-18(27)13-32/h3-4,10-12,16,18-19H,7-9,13-15H2,1-2H3,(H2,28,29,30)/b4-3+/t18-/m1/s1
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n/an/a 6.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161435
PNG
(US10124003, Ex. Compound 49 | US9108973, 48)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CC[C@@H](F)C2)c2ncnc(N)c12
Show InChI InChI=1S/C28H31FN6O3/c1-37-23-12-19(13-24(14-23)38-2)5-6-20-15-35(28-26(20)27(30)31-18-32-28)22-8-11-34(17-22)25(36)4-3-9-33-10-7-21(29)16-33/h3-4,12-15,18,21-22H,7-11,16-17H2,1-2H3,(H2,30,31,32)/b4-3+/t21-,22+/m1/s1
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n/an/a 6.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161395
PNG
(US10124003, Ex. Compound 8 | US9108973, 8)
Show SMILES CCOc1cc(OCC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H26N6O3/c1-4-21(31)29-10-9-17(14-29)30-24-22(23(25)26-15-27-24)20(28-30)8-7-16-11-18(32-5-2)13-19(12-16)33-6-3/h4,11-13,15,17H,1,5-6,9-10,14H2,2-3H3,(H2,25,26,27)/t17-/m0/s1
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n/an/a 6.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161452
PNG
(US10124003, Ex. Compound 65 | US9108973, 65)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C27H32N6O3/c1-31(2)11-5-6-24(34)32-12-9-21(10-13-32)33-17-20(25-26(28)29-18-30-27(25)33)8-7-19-14-22(35-3)16-23(15-19)36-4/h5-6,14-18,21H,9-13H2,1-4H3,(H2,28,29,30)/b6-5+
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n/an/a 7n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161435
PNG
(US10124003, Ex. Compound 49 | US9108973, 48)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)\C=C\CN2CC[C@@H](F)C2)c2ncnc(N)c12
Show InChI InChI=1S/C28H31FN6O3/c1-37-23-12-19(13-24(14-23)38-2)5-6-20-15-35(28-26(20)27(30)31-18-32-28)22-8-11-34(17-22)25(36)4-3-9-33-10-7-21(29)16-33/h3-4,12-15,18,21-22H,7-11,16-17H2,1-2H3,(H2,30,31,32)/b4-3+/t21-,22+/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161411
PNG
(US10124003, Ex. Compound 24 | US9108973, 24)
Show SMILES CCOc1cc(OCC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C23H24N6O3/c1-4-20(30)28-12-16(13-28)29-23-21(22(24)25-14-26-23)19(27-29)8-7-15-9-17(31-5-2)11-18(10-15)32-6-3/h4,9-11,14,16H,1,5-6,12-13H2,2-3H3,(H2,24,25,26)
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n/an/a 7.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161451
PNG
(US10124003, Ex. Compound 64 | US9108973, 64)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H25N5O3/c1-4-21(30)28-9-7-18(8-10-28)29-14-17(22-23(25)26-15-27-24(22)29)6-5-16-11-19(31-2)13-20(12-16)32-3/h4,11-15,18H,1,7-10H2,2-3H3,(H2,25,26,27)
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n/an/a 7.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM298388
PNG
(US10124003, Ex. Compound 69)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@@H]2C[C@@H](N(C2)C(=O)C=C)c2nnc(C)o2)c2ncnc(N)c12
Show InChI InChI=1S/C26H25N7O4/c1-5-22(34)33-13-18(10-21(33)26-31-30-15(2)37-26)32-12-17(23-24(27)28-14-29-25(23)32)7-6-16-8-19(35-3)11-20(9-16)36-4/h5,8-9,11-12,14,18,21H,1,10,13H2,2-4H3,(H2,27,28,29)/t18-,21-/m1/s1
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n/an/a 8.80n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161416
PNG
(US10124003, Ex. Compound 29 | US9108973, 29)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(CC2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-10-15(11-27)12-28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-7-16(30-2)9-17(8-14)31-3/h4,7-9,13,15H,1,10-12H2,2-3H3,(H2,23,24,25)
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n/an/a 9.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161465
PNG
(US10124003, Ref. Ex. Compound 6 | US9108973, Ref 6)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@@H](C1)n1nc(C#Cc2cccc(NC(C)=O)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H28N8O2/c1-17(34)29-19-7-4-6-18(14-19)9-10-21-23-24(26)27-16-28-25(23)33(30-21)20-11-13-32(15-20)22(35)8-5-12-31(2)3/h4-8,14,16,20H,11-13,15H2,1-3H3,(H,29,34)(H2,26,27,28)/b8-5+/t20-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161389
PNG
(US10124003, Ref. Ex. Compound 3 | US9108973, 2)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161464
PNG
(US10124003, Ref. Ex. Compound 5 | US9108973, Ref 5)
Show SMILES COc1cccc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C24H27N7O2/c1-29(2)12-5-8-21(32)30-13-11-18(15-30)31-24-22(23(25)26-16-27-24)20(28-31)10-9-17-6-4-7-19(14-17)33-3/h4-8,14,16,18H,11-13,15H2,1-3H3,(H2,25,26,27)/b8-5+/t18-/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161461
PNG
(US10124003, Ref. Ex. Compound 2 | US9108973, Ref 2)
Show SMILES Nc1nccn2c(nc(C#Cc3ccccc3)c12)C1CCC1
Show InChI InChI=1S/C18H16N4/c19-17-16-15(10-9-13-5-2-1-3-6-13)21-18(14-7-4-8-14)22(16)12-11-20-17/h1-3,5-6,11-12,14H,4,7-8H2,(H2,19,20)
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n/an/a 270n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50357312
PNG
(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1
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n/an/a 280n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161466
PNG
(US10124003, Ref. Ex. Compound 7 | US9108973, Ref 7)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@@H](C1)n1nc(C#Cc2cccnc2)c2c(N)ncnc12
Show InChI InChI=1S/C22H24N8O/c1-28(2)11-4-6-19(31)29-12-9-17(14-29)30-22-20(21(23)25-15-26-22)18(27-30)8-7-16-5-3-10-24-13-16/h3-6,10,13,15,17H,9,11-12,14H2,1-2H3,(H2,23,25,26)/b6-4+/t17-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM161463
PNG
(US10124003, Ref. Ex. Compound 4 | US9108973, Ref 4)
Show SMILES CC(C)c1cc(cc(c1)C(C)C)C#Cc1nn([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C29H37N7O/c1-19(2)22-14-21(15-23(16-22)20(3)4)9-10-25-27-28(30)31-18-32-29(27)36(33-25)24-11-13-35(17-24)26(37)8-7-12-34(5)6/h7-8,14-16,18-20,24H,11-13,17H2,1-6H3,(H2,30,31,32)/b8-7+/t24-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US10124003 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%