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Patent code US10125111

Compile Data Set for Download or QSAR
Found 99 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298497
PNG
(US10125111, Compound 1002)
Show SMILES CNC(=O)c1c(oc2cc(N(CC#N)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H26F4N4O5S/c1-29(2,30(32,33)34)37-27(39)19-7-5-6-18(14-19)21-15-22-24(16-23(21)38(13-12-35)44(4,41)42)43-26(25(22)28(40)36-3)17-8-10-20(31)11-9-17/h5-11,14-16H,13H2,1-4H3,(H,36,40)(H,37,39)
PDB

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US Patent
n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298501
PNG
(US10125111, Compound 2004)
Show SMILES CNC(=O)c1c(oc2cc(N(CC3CC3)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(CF)(CF)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C32H31F4N3O5S/c1-37-31(41)28-25-13-24(21-4-3-5-22(12-21)30(40)38-32(16-33,17-34)18-35)26(39(45(2,42)43)15-19-6-7-19)14-27(25)44-29(28)20-8-10-23(36)11-9-20/h3-5,8-14,19H,6-7,15-18H2,1-2H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298502
PNG
(US10125111, Compound 2005)
Show SMILES CNC(=O)c1c(oc2cc(N(CC3CC3)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C32H31FN4O5S/c1-32(2,18-34)36-30(38)22-7-5-6-21(14-22)24-15-25-27(16-26(24)37(43(4,40)41)17-19-8-9-19)42-29(28(25)31(39)35-3)20-10-12-23(33)13-11-20/h5-7,10-16,19H,8-9,17H2,1-4H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a 14.7n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298504
PNG
(US10125111, Compound 3003)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F5N3O5S/c1-29(2,30(33,34)35)37-27(39)19-7-5-6-18(14-19)21-15-22-24(16-23(21)38(13-12-31)44(4,41)42)43-26(25(22)28(40)36-3)17-8-10-20(32)11-9-17/h5-11,14-16H,12-13H2,1-4H3,(H,36,40)(H,37,39)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298512
PNG
(US10125111, Compound 3011)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(CC1)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C30H26F2N4O5S/c1-34-29(38)26-23-15-22(19-4-3-5-20(14-19)28(37)35-30(17-33)10-11-30)24(36(13-12-31)42(2,39)40)16-25(23)41-27(26)18-6-8-21(32)9-7-18/h3-9,14-16H,10-13H2,1-2H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298551
PNG
(US10125111, Compound 4007)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(F)(F)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H26F7N3O5S/c1-38-28(42)25-22-14-21(18-5-3-6-19(13-18)27(41)39-16-29(33,34)30(35,36)37)23(40(12-4-11-31)46(2,43)44)15-24(22)45-26(25)17-7-9-20(32)10-8-17/h3,5-10,13-15H,4,11-12,16H2,1-2H3,(H,38,42)(H,39,41)
PDB

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n/an/an/an/a 5.30n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298569
PNG
(US10125111, Compound 4025)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C1CC1)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H35F2N3O5S/c1-37-34(41)30-27-18-26(23-5-3-6-24(17-23)33(40)38-31(20-7-8-20)21-9-10-21)28(39(16-4-15-35)45(2,42)43)19-29(27)44-32(30)22-11-13-25(36)14-12-22/h3,5-6,11-14,17-21,31H,4,7-10,15-16H2,1-2H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298573
PNG
(US10125111, Compound 4029)
Show SMILES CCC(C)(NC(=O)c1cccc(c1)-c1cc2c(C(=O)NC)c(oc2cc1N(CCCF)S(C)(=O)=O)-c1ccc(F)cc1)C#C
Show InChI InChI=1S/C33H33F2N3O5S/c1-6-33(3,7-2)37-31(39)23-11-8-10-22(18-23)25-19-26-28(20-27(25)38(17-9-16-34)44(5,41)42)43-30(29(26)32(40)36-4)21-12-14-24(35)15-13-21/h1,8,10-15,18-20H,7,9,16-17H2,2-5H3,(H,36,40)(H,37,39)
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n/an/an/an/a 5.90n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298575
PNG
(US10125111, Compound 5003)
Show SMILES CNC(=O)c1c(oc2cc(NCCCF)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F2N4O3/c1-30(2,17-33)36-28(37)20-7-4-6-19(14-20)22-15-23-25(16-24(22)35-13-5-12-31)39-27(26(23)29(38)34-3)18-8-10-21(32)11-9-18/h4,6-11,14-16,35H,5,12-13H2,1-3H3,(H,34,38)(H,36,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298592
PNG
(US10125111, Compound 9005)
Show SMILES CNC(=O)c1c(oc2cc(N(CCC(F)(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(CF)(CF)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C31H28F7N3O5S/c1-39-29(43)26-23-13-22(19-4-3-5-20(12-19)28(42)40-30(15-32,16-33)17-34)24(41(47(2,44)45)11-10-31(36,37)38)14-25(23)46-27(26)18-6-8-21(35)9-7-18/h3-9,12-14H,10-11,15-17H2,1-2H3,(H,39,43)(H,40,42)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298499
PNG
(US10125111, Compound 2002)
Show SMILES CNC(=O)c1c(oc2cc(N(CC3CC3)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C28H25FN2O6S/c1-30-27(32)25-22-13-21(18-4-3-5-19(12-18)28(33)34)23(31(38(2,35)36)15-16-6-7-16)14-24(22)37-26(25)17-8-10-20(29)11-9-17/h3-5,8-14,16H,6-7,15H2,1-2H3,(H,30,32)(H,33,34)
PDB

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n/an/an/an/a 7.56E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298514
PNG
(US10125111, Compound 3013)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C30H30F3N3O5S/c1-30(2,17-32)35-28(37)20-7-5-6-19(14-20)22-15-23-25(16-24(22)36(13-12-31)42(4,39)40)41-27(26(23)29(38)34-3)18-8-10-21(33)11-9-18/h5-11,14-16H,12-13,17H2,1-4H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298515
PNG
(US10125111, Compound 3014)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(=O)OC)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31F2N3O7S/c1-31(2,30(39)42-4)35-28(37)20-8-6-7-19(15-20)22-16-23-25(17-24(22)36(14-13-32)44(5,40)41)43-27(26(23)29(38)34-3)18-9-11-21(33)12-10-18/h6-12,15-17H,13-14H2,1-5H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298520
PNG
(US10125111, Compound 3019)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCN(C)CC1c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C37H36F2N4O5S/c1-40-36(44)34-30-21-29(31(43(17-16-38)49(3,46)47)22-33(30)48-35(34)25-12-14-28(39)15-13-25)26-10-7-11-27(20-26)37(45)42-19-18-41(2)23-32(42)24-8-5-4-6-9-24/h4-15,20-22,32H,16-19,23H2,1-3H3,(H,40,44)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298526
PNG
(US10125111, Compound 3025)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCN(CC1)c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H34F2N4O5S/c1-39-35(43)33-30-22-29(25-7-6-8-26(21-25)36(44)41-19-17-40(18-20-41)28-9-4-3-5-10-28)31(42(16-15-37)48(2,45)46)23-32(30)47-34(33)24-11-13-27(38)14-12-24/h3-14,21-23H,15-20H2,1-2H3,(H,39,43)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298530
PNG
(US10125111, Compound 3029)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C35H37F2N3O7S/c1-35(2,3)47-34(43)27-10-7-16-39(27)33(42)23-9-6-8-22(18-23)25-19-26-29(20-28(25)40(17-15-36)48(5,44)45)46-31(30(26)32(41)38-4)21-11-13-24(37)14-12-21/h6,8-9,11-14,18-20,27H,7,10,15-17H2,1-5H3,(H,38,41)/t27-/m0/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298532
PNG
(US10125111, Compound 3031)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCN(CC1c1ccccc1)C(=O)OC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C41H42F2N4O7S/c1-41(2,3)54-40(50)45-20-21-46(34(25-45)26-10-7-6-8-11-26)39(49)29-13-9-12-28(22-29)31-23-32-35(24-33(31)47(19-18-42)55(5,51)52)53-37(36(32)38(48)44-4)27-14-16-30(43)17-15-27/h6-17,22-24,34H,18-21,25H2,1-5H3,(H,44,48)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298543
PNG
(US10125111, Compound 3042)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CC(C1)NC(=O)OC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C34H36F2N4O7S/c1-34(2,3)47-33(43)38-24-18-39(19-24)32(42)22-8-6-7-21(15-22)25-16-26-28(17-27(25)40(14-13-35)48(5,44)45)46-30(29(26)31(41)37-4)20-9-11-23(36)12-10-20/h6-12,15-17,24H,13-14,18-19H2,1-5H3,(H,37,41)(H,38,43)
PDB

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n/an/an/an/a 138n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298547
PNG
(US10125111, Compound 4003)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F5N3O5S/c1-17(30(33,34)35)37-28(39)20-7-4-6-19(14-20)22-15-23-25(16-24(22)38(13-5-12-31)44(3,41)42)43-27(26(23)29(40)36-2)18-8-10-21(32)11-9-18/h4,6-11,14-17H,5,12-13H2,1-3H3,(H,36,40)(H,37,39)
PDB

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UniChem
US Patent
n/an/an/an/a 9.30n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298554
PNG
(US10125111, Compound 4010)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C29H26F5N3O5S/c1-35-28(39)25-22-14-21(18-5-3-6-19(13-18)27(38)36-16-29(32,33)34)23(37(12-4-11-30)43(2,40)41)15-24(22)42-26(25)17-7-9-20(31)10-8-17/h3,5-10,13-15H,4,11-12,16H2,1-2H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298563
PNG
(US10125111, Compound 4019)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(C)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H29F4N3O5S/c1-30(33,34)17-36-28(38)20-7-4-6-19(14-20)22-15-23-25(16-24(22)37(13-5-12-31)43(3,40)41)42-27(26(23)29(39)35-2)18-8-10-21(32)11-9-18/h4,6-11,14-16H,5,12-13,17H2,1-3H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a 9.80n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298566
PNG
(US10125111, Compound 4022)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(C)CCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33F2N3O5S/c1-32(13-5-14-32)36-30(38)22-8-4-7-21(17-22)24-18-25-27(19-26(24)37(16-6-15-33)43(3,40)41)42-29(28(25)31(39)35-2)20-9-11-23(34)12-10-20/h4,7-12,17-19H,5-6,13-16H2,1-3H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a 7.70n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298579
PNG
(US10125111, Compound 6001)
Show SMILES CNC(=O)c1c(oc2cc(N(C(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)OC)-c1ccc(F)cc1
Show InChI InChI=1S/C26H21F3N2O6S/c1-30-24(32)22-19-12-18(15-5-4-6-16(11-15)25(33)36-2)20(31(26(28)29)38(3,34)35)13-21(19)37-23(22)14-7-9-17(27)10-8-14/h4-13,26H,1-3H3,(H,30,32)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298587
PNG
(US10125111, Compound 7004)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(CF)(CF)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C30H27F6N3O5S/c1-37-29(41)26-22-11-21(18-4-3-5-19(10-18)28(40)38-30(14-31,15-32)16-33)23(39(13-25(35)36)45(2,42)43)12-24(22)44-27(26)17-6-8-20(34)9-7-17/h3-12,25H,13-16H2,1-2H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298510
PNG
(US10125111, Compound 3009)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N[C@@H](C)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31F2N3O5S/c1-18(19-7-8-19)35-30(37)22-6-4-5-21(15-22)24-16-25-27(17-26(24)36(14-13-32)42(3,39)40)41-29(28(25)31(38)34-2)20-9-11-23(33)12-10-20/h4-6,9-12,15-19H,7-8,13-14H2,1-3H3,(H,34,38)(H,35,37)/t18-/m0/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298519
PNG
(US10125111, Compound 3018)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCCC1c1ccc(Cl)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H32ClF2N3O5S/c1-40-35(43)33-29-20-28(24-5-3-6-25(19-24)36(44)41-17-4-7-30(41)22-8-12-26(37)13-9-22)31(42(18-16-38)48(2,45)46)21-32(29)47-34(33)23-10-14-27(39)15-11-23/h3,5-6,8-15,19-21,30H,4,7,16-18H2,1-2H3,(H,40,43)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298522
PNG
(US10125111, Compound 3021)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N[C@H](C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C29H26F5N3O5S/c1-16(29(32,33)34)36-27(38)19-6-4-5-18(13-19)21-14-22-24(15-23(21)37(12-11-30)43(3,40)41)42-26(25(22)28(39)35-2)17-7-9-20(31)10-8-17/h4-10,13-16H,11-12H2,1-3H3,(H,35,39)(H,36,38)/t16-/m1/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298535
PNG
(US10125111, Compound 3034)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC(C1)c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H32F3N3O5S/c1-40-35(43)33-30-19-29(24-4-3-5-25(18-24)36(44)41-16-14-26(21-41)22-6-10-27(38)11-7-22)31(42(17-15-37)48(2,45)46)20-32(30)47-34(33)23-8-12-28(39)13-9-23/h3-13,18-20,26H,14-17,21H2,1-2H3,(H,40,43)
PDB

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n/an/an/an/a 11.7n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298536
PNG
(US10125111, Compound 3035)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC[C@H]1CO)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31F2N3O6S/c1-34-30(38)28-25-16-24(20-5-3-6-21(15-20)31(39)35-13-4-7-23(35)18-37)26(36(14-12-32)43(2,40)41)17-27(25)42-29(28)19-8-10-22(33)11-9-19/h3,5-6,8-11,15-17,23,37H,4,7,12-14,18H2,1-2H3,(H,34,38)/t23-/m0/s1
PDB

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n/an/an/an/a 550n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298538
PNG
(US10125111, Compound 3037)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CC[C@H](O)C1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H29F2N3O6S/c1-33-29(37)27-24-15-23(19-4-3-5-20(14-19)30(38)34-12-10-22(36)17-34)25(35(13-11-31)42(2,39)40)16-26(24)41-28(27)18-6-8-21(32)9-7-18/h3-9,14-16,22,36H,10-13,17H2,1-2H3,(H,33,37)/t22-/m0/s1
PDB

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n/an/an/an/a>1.00E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298542
PNG
(US10125111, Compound 3041)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)OC)-c1ccc(F)cc1
Show InChI InChI=1S/C32H31F2N3O7S/c1-35-30(38)28-24-17-23(20-6-4-7-21(16-20)31(39)36-14-5-8-25(36)32(40)43-2)26(37(15-13-33)45(3,41)42)18-27(24)44-29(28)19-9-11-22(34)12-10-19/h4,6-7,9-12,16-18,25H,5,8,13-15H2,1-3H3,(H,35,38)/t25-/m0/s1
PDB

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n/an/an/an/a 550n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298548
PNG
(US10125111, Compound 4004)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(CF)(CF)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C31H30F5N3O5S/c1-37-30(41)27-24-14-23(20-5-3-6-21(13-20)29(40)38-31(16-33,17-34)18-35)25(39(12-4-11-32)45(2,42)43)15-26(24)44-28(27)19-7-9-22(36)10-8-19/h3,5-10,13-15H,4,11-12,16-18H2,1-2H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298550
PNG
(BDBM298555 | US10125111, Compound 4006)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C31H33F2N3O5S/c1-31(2,3)35-29(37)21-9-6-8-20(16-21)23-17-24-26(18-25(23)36(15-7-14-32)42(5,39)40)41-28(27(24)30(38)34-4)19-10-12-22(33)13-11-19/h6,8-13,16-18H,7,14-15H2,1-5H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298557
PNG
(US10125111, Compound 4013)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(=O)OC)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33F2N3O7S/c1-32(2,31(40)43-4)36-29(38)21-9-6-8-20(16-21)23-17-24-26(18-25(23)37(15-7-14-33)45(5,41)42)44-28(27(24)30(39)35-3)19-10-12-22(34)13-11-19/h6,8-13,16-18H,7,14-15H2,1-5H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298558
PNG
(US10125111, Compound 4014)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(CC1)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C31H28F2N4O5S/c1-35-30(39)27-24-16-23(20-5-3-6-21(15-20)29(38)36-31(18-34)11-12-31)25(37(14-4-13-32)43(2,40)41)17-26(24)42-28(27)19-7-9-22(33)10-8-19/h3,5-10,15-17H,4,11-14H2,1-2H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298565
PNG
(US10125111, Compound 4021)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N[C@@H](C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F5N3O5S/c1-17(30(33,34)35)37-28(39)20-7-4-6-19(14-20)22-15-23-25(16-24(22)38(13-5-12-31)44(3,41)42)43-27(26(23)29(40)36-2)18-8-10-21(32)11-9-18/h4,6-11,14-17H,5,12-13H2,1-3H3,(H,36,40)(H,37,39)/t17-/m0/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298578
PNG
(US10125111, Compound 5006)
Show SMILES CNC(=O)c1c(oc2cc(NCCCF)c(cc12)-c1cccc(c1)C(=O)NC(CF)(CF)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F5N3O3/c1-36-29(40)26-23-13-22(19-4-2-5-20(12-19)28(39)38-30(15-32,16-33)17-34)24(37-11-3-10-31)14-25(23)41-27(26)18-6-8-21(35)9-7-18/h2,4-9,12-14,37H,3,10-11,15-17H2,1H3,(H,36,40)(H,38,39)
PDB

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n/an/an/an/a 9.40n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298585
PNG
(US10125111, Compound 7001)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)OC)-c1ccc(F)cc1
Show InChI InChI=1S/C27H23F3N2O6S/c1-31-26(33)24-20-12-19(16-5-4-6-17(11-16)27(34)37-2)21(32(14-23(29)30)39(3,35)36)13-22(20)38-25(24)15-7-9-18(28)10-8-15/h4-13,23H,14H2,1-3H3,(H,31,33)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298589
PNG
(US10125111, Compound 9002)
Show SMILES CNC(=O)c1c(oc2cc(N(CCC(F)(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C27H22F4N2O6S/c1-32-25(34)23-20-13-19(16-4-3-5-17(12-16)26(35)36)21(33(40(2,37)38)11-10-27(29,30)31)14-22(20)39-24(23)15-6-8-18(28)9-7-15/h3-9,12-14H,10-11H2,1-2H3,(H,32,34)(H,35,36)
PDB

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n/an/an/an/a>1.00E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298500
PNG
(US10125111, Compound 2003)
Show SMILES CNC(=O)c1c(oc2cc(N(CC3CC3)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C32H31F4N3O5S/c1-31(2,32(34,35)36)38-29(40)21-7-5-6-20(14-21)23-15-24-26(16-25(23)39(45(4,42)43)17-18-8-9-18)44-28(27(24)30(41)37-3)19-10-12-22(33)13-11-19/h5-7,10-16,18H,8-9,17H2,1-4H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298505
PNG
(US10125111, Compound 3004)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(CF)(CF)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F5N3O5S/c1-36-29(40)26-23-13-22(19-4-3-5-20(12-19)28(39)37-30(15-32,16-33)17-34)24(38(11-10-31)44(2,41)42)14-25(23)43-27(26)18-6-8-21(35)9-7-18/h3-9,12-14H,10-11,15-17H2,1-2H3,(H,36,40)(H,37,39)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298508
PNG
(US10125111, Compound 3007)
Show SMILES CC[C@@H](NC(=O)c1cccc(c1)-c1cc2c(C(=O)NC)c(oc2cc1N(CCF)S(C)(=O)=O)-c1ccc(F)cc1)C1CC1
Show InChI InChI=1S/C32H33F2N3O5S/c1-4-26(19-8-9-19)36-31(38)22-7-5-6-21(16-22)24-17-25-28(18-27(24)37(15-14-33)43(3,40)41)42-30(29(25)32(39)35-2)20-10-12-23(34)13-11-20/h5-7,10-13,16-19,26H,4,8-9,14-15H2,1-3H3,(H,35,39)(H,36,38)/t26-/m1/s1
PDB

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n/an/an/an/a 5.70n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298509
PNG
(US10125111, Compound 3008)
Show SMILES CC[C@H](NC(=O)c1cccc(c1)-c1cc2c(C(=O)NC)c(oc2cc1N(CCF)S(C)(=O)=O)-c1ccc(F)cc1)C1CC1
Show InChI InChI=1S/C32H33F2N3O5S/c1-4-26(19-8-9-19)36-31(38)22-7-5-6-21(16-22)24-17-25-28(18-27(24)37(15-14-33)43(3,40)41)42-30(29(25)32(39)35-2)20-10-12-23(34)13-11-20/h5-7,10-13,16-19,26H,4,8-9,14-15H2,1-3H3,(H,35,39)(H,36,38)/t26-/m0/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298511
PNG
(US10125111, Compound 3010)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C1CC1)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H33F2N3O5S/c1-36-33(40)29-26-17-25(22-4-3-5-23(16-22)32(39)37-30(19-6-7-19)20-8-9-20)27(38(15-14-34)44(2,41)42)18-28(26)43-31(29)21-10-12-24(35)13-11-21/h3-5,10-13,16-20,30H,6-9,14-15H2,1-2H3,(H,36,40)(H,37,39)
PDB

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n/an/an/an/a 5.60n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298518
PNG
(US10125111, Compound 3017)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC(C)(C)C1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33F2N3O5S/c1-32(2)12-14-36(19-32)31(39)22-7-5-6-21(16-22)24-17-25-27(18-26(24)37(15-13-33)43(4,40)41)42-29(28(25)30(38)35-3)20-8-10-23(34)11-9-20/h5-11,16-18H,12-15,19H2,1-4H3,(H,35,38)
PDB

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n/an/an/an/a 6.30n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298521
PNG
(US10125111, Compound 3020)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCN(CC1)c1ccc(Cl)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H33ClF2N4O5S/c1-40-35(44)33-30-21-29(31(43(15-14-38)49(2,46)47)22-32(30)48-34(33)23-6-10-27(39)11-7-23)24-4-3-5-25(20-24)36(45)42-18-16-41(17-19-42)28-12-8-26(37)9-13-28/h3-13,20-22H,14-19H2,1-2H3,(H,40,44)
PDB

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n/an/an/an/a 9.40n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298537
PNG
(US10125111, Compound 3036)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC(C1)NC(C)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C32H32F2N4O6S/c1-19(39)36-24-11-13-37(18-24)32(41)22-6-4-5-21(15-22)25-16-26-28(17-27(25)38(14-12-33)45(3,42)43)44-30(29(26)31(40)35-2)20-7-9-23(34)10-8-20/h4-10,15-17,24H,11-14,18H2,1-3H3,(H,35,40)(H,36,39)
PDB

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n/an/an/an/a>1.00E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298541
PNG
(US10125111, Compound 3040)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC(C1)c1cccc(Cl)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C36H32ClF2N3O5S/c1-40-35(43)33-30-19-29(24-6-3-7-25(17-24)36(44)41-15-13-26(21-41)23-5-4-8-27(37)18-23)31(42(16-14-38)48(2,45)46)20-32(30)47-34(33)22-9-11-28(39)12-10-22/h3-12,17-20,26H,13-16,21H2,1-2H3,(H,40,43)
PDB

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n/an/an/an/a 41.3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298546
PNG
(US10125111, Compound 4002)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C27H24F2N2O6S/c1-30-26(32)24-21-14-20(17-5-3-6-18(13-17)27(33)34)22(31(12-4-11-28)38(2,35)36)15-23(21)37-25(24)16-7-9-19(29)10-8-16/h3,5-10,13-15H,4,11-12H2,1-2H3,(H,30,32)(H,33,34)
PDB

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n/an/an/an/a>1.00E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298562
PNG
(US10125111, Compound 4018)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)CO)-c1ccc(F)cc1
Show InChI InChI=1S/C31H33F2N3O6S/c1-31(2,18-37)35-29(38)21-8-5-7-20(15-21)23-16-24-26(17-25(23)36(14-6-13-32)43(4,40)41)42-28(27(24)30(39)34-3)19-9-11-22(33)12-10-19/h5,7-12,15-17,37H,6,13-14,18H2,1-4H3,(H,34,39)(H,35,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298581
PNG
(US10125111, Compound 6003)
Show SMILES CNC(=O)c1c(oc2cc(N(C(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C29H25F6N3O5S/c1-28(2,29(33,34)35)37-25(39)17-7-5-6-16(12-17)19-13-20-22(14-21(19)38(27(31)32)44(4,41)42)43-24(23(20)26(40)36-3)15-8-10-18(30)11-9-15/h5-14,27H,1-4H3,(H,36,40)(H,37,39)
PDB

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n/an/an/an/a 9.5n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298593
PNG
(US10125111, Compound 9006)
Show SMILES CNC(=O)c1c(oc2cc(N(CCC(F)(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C31H28F4N4O5S/c1-30(2,17-36)38-28(40)20-7-5-6-19(14-20)22-15-23-25(16-24(22)39(45(4,42)43)13-12-31(33,34)35)44-27(26(23)29(41)37-3)18-8-10-21(32)11-9-18/h5-11,14-16H,12-13H2,1-4H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298496
PNG
(US10125111, Compound 1001)
Show SMILES CNC(=O)c1c(oc2cc(N(CC#N)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)OC)-c1ccc(F)cc1
Show InChI InChI=1S/C27H22FN3O6S/c1-30-26(32)24-21-14-20(17-5-4-6-18(13-17)27(33)36-2)22(31(12-11-29)38(3,34)35)15-23(21)37-25(24)16-7-9-19(28)10-8-16/h4-10,13-15H,12H2,1-3H3,(H,30,32)
PDB

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n/an/an/an/a 57.8n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298498
PNG
(US10125111, Compound 2001)
Show SMILES CNC(=O)c1c(oc2cc(N(CC3CC3)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)OC)-c1ccc(F)cc1
Show InChI InChI=1S/C29H27FN2O6S/c1-31-28(33)26-23-14-22(19-5-4-6-20(13-19)29(34)37-2)24(32(39(3,35)36)16-17-7-8-17)15-25(23)38-27(26)18-9-11-21(30)12-10-18/h4-6,9-15,17H,7-8,16H2,1-3H3,(H,31,33)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298503
PNG
(US10125111, Compound 2006)
Show SMILES CNC(=O)c1c(oc2cc(N(CC3CC3)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C32H34FN3O5S/c1-32(2,3)35-30(37)22-8-6-7-21(15-22)24-16-25-27(17-26(24)36(42(5,39)40)18-19-9-10-19)41-29(28(25)31(38)34-4)20-11-13-23(33)14-12-20/h6-8,11-17,19H,9-10,18H2,1-5H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298507
PNG
(BDBM298517 | US10125111, Compound 3006)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C30H31F2N3O5S/c1-30(2,3)34-28(36)20-8-6-7-19(15-20)22-16-23-25(17-24(22)35(14-13-31)41(5,38)39)40-27(26(23)29(37)33-4)18-9-11-21(32)12-10-18/h6-12,15-17H,13-14H2,1-5H3,(H,33,37)(H,34,36)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298531
PNG
(US10125111, Compound 3030)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC[C@@H]1CO)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31F2N3O6S/c1-34-30(38)28-25-16-24(20-5-3-6-21(15-20)31(39)35-13-4-7-23(35)18-37)26(36(14-12-32)43(2,40)41)17-27(25)42-29(28)19-8-10-22(33)11-9-19/h3,5-6,8-11,15-17,23,37H,4,7,12-14,18H2,1-2H3,(H,34,38)/t23-/m1/s1
PDB

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n/an/an/an/a 139n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298545
PNG
(US10125111, Compound 3044)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCN(CC1(C)C)C(=O)OC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C37H42F2N4O7S/c1-36(2,3)50-35(46)41-17-18-42(37(4,5)22-41)34(45)25-10-8-9-24(19-25)27-20-28-30(21-29(27)43(16-15-38)51(7,47)48)49-32(31(28)33(44)40-6)23-11-13-26(39)14-12-23/h8-14,19-21H,15-18,22H2,1-7H3,(H,40,44)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298549
PNG
(US10125111, Compound 4005)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C31H30F5N3O5S/c1-30(2,31(34,35)36)38-28(40)20-8-5-7-19(15-20)22-16-23-25(17-24(22)39(14-6-13-32)45(4,42)43)44-27(26(23)29(41)37-3)18-9-11-21(33)12-10-18/h5,7-12,15-17H,6,13-14H2,1-4H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298552
PNG
(US10125111, Compound 4008)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C31H32F3N3O5S/c1-31(2,18-33)36-29(38)21-8-5-7-20(15-21)23-16-24-26(17-25(23)37(14-6-13-32)43(4,40)41)42-28(27(24)30(39)35-3)19-9-11-22(34)12-10-19/h5,7-12,15-17H,6,13-14,18H2,1-4H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298568
PNG
(US10125111, Compound 4024)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C31H30F2N4O5S/c1-31(2,18-34)36-29(38)21-8-5-7-20(15-21)23-16-24-26(17-25(23)37(14-6-13-32)43(4,40)41)42-28(27(24)30(39)35-3)19-9-11-22(33)12-10-19/h5,7-12,15-17H,6,13-14H2,1-4H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298570
PNG
(US10125111, Compound 4026)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C34H39F2N3O5S/c1-33(2,3)34(4,5)38-31(40)23-11-8-10-22(18-23)25-19-26-28(20-27(25)39(17-9-16-35)45(7,42)43)44-30(29(26)32(41)37-6)21-12-14-24(36)15-13-21/h8,10-15,18-20H,9,16-17H2,1-7H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298582
PNG
(US10125111, Compound 6004)
Show SMILES CNC(=O)c1c(oc2cc(N(C(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C29H25F3N4O5S/c1-29(2,15-33)35-26(37)18-7-5-6-17(12-18)20-13-21-23(14-22(20)36(28(31)32)42(4,39)40)41-25(24(21)27(38)34-3)16-8-10-19(30)11-9-16/h5-14,28H,1-4H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298507
PNG
(BDBM298517 | US10125111, Compound 3006)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C30H31F2N3O5S/c1-30(2,3)34-28(36)20-8-6-7-19(15-20)22-16-23-25(17-24(22)35(14-13-31)41(5,38)39)40-27(26(23)29(37)33-4)18-9-11-21(32)12-10-18/h6-12,15-17H,13-14H2,1-5H3,(H,33,37)(H,34,36)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298525
PNG
(US10125111, Compound 3024)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCCC1C)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31F2N3O5S/c1-19-6-5-14-35(19)31(38)22-8-4-7-21(16-22)24-17-25-27(18-26(24)36(15-13-32)42(3,39)40)41-29(28(25)30(37)34-2)20-9-11-23(33)12-10-20/h4,7-12,16-19H,5-6,13-15H2,1-3H3,(H,34,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298544
PNG
(US10125111, Compound 3043)
Show SMILES CCCC1CN(CCN1C(=O)c1cccc(c1)-c1cc2c(C(=O)NC)c(oc2cc1N(CCF)S(C)(=O)=O)-c1ccc(F)cc1)C(=O)c1ccccc1
Show InChI InChI=1S/C40H40F2N4O6S/c1-4-9-31-25-44(39(48)27-10-6-5-7-11-27)20-21-45(31)40(49)29-13-8-12-28(22-29)32-23-33-35(24-34(32)46(19-18-41)53(3,50)51)52-37(36(33)38(47)43-2)26-14-16-30(42)17-15-26/h5-8,10-17,22-24,31H,4,9,18-21,25H2,1-3H3,(H,43,47)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298550
PNG
(BDBM298555 | US10125111, Compound 4006)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C31H33F2N3O5S/c1-31(2,3)35-29(37)21-9-6-8-20(16-21)23-17-24-26(18-25(23)36(15-7-14-32)42(5,39)40)41-28(27(24)30(38)34-4)19-10-12-22(33)13-11-19/h6,8-13,16-18H,7,14-15H2,1-5H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298564
PNG
(US10125111, Compound 4020)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C29H27F4N3O5S/c1-34-29(38)26-22-14-21(18-5-3-6-19(13-18)28(37)35-16-25(32)33)23(36(12-4-11-30)42(2,39)40)15-24(22)41-27(26)17-7-9-20(31)10-8-17/h3,5-10,13-15,25H,4,11-12,16H2,1-2H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298583
PNG
(US10125111, Compound 6005)
Show SMILES CNC(=O)c1c(oc2cc(N(C(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(CF)(CF)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C29H25F6N3O5S/c1-36-27(40)24-21-11-20(17-4-3-5-18(10-17)26(39)37-29(13-30,14-31)15-32)22(38(28(34)35)44(2,41)42)12-23(21)43-25(24)16-6-8-19(33)9-7-16/h3-12,28H,13-15H2,1-2H3,(H,36,40)(H,37,39)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298588
PNG
(US10125111, Compound 8001)
Show SMILES CNC(=O)c1c(oc2cc(N(CC=C(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)OC)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23F3N2O6S/c1-32-27(34)25-21-14-20(17-5-4-6-18(13-17)28(35)38-2)22(33(40(3,36)37)12-11-24(30)31)15-23(21)39-26(25)16-7-9-19(29)10-8-16/h4-11,13-15H,12H2,1-3H3,(H,32,34)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298594
PNG
(US10125111, Compound 9007)
Show SMILES CNC(=O)c1c(oc2cc(N(CCC(F)(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)CF)-c1ccc(F)cc1
Show InChI InChI=1S/C31H30F5N3O5S/c1-30(2,17-32)38-28(40)20-7-5-6-19(14-20)22-15-23-25(16-24(22)39(45(4,42)43)13-12-31(34,35)36)44-27(26(23)29(41)37-3)18-8-10-21(33)11-9-18/h5-11,14-16H,12-13,17H2,1-4H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298513
PNG
(US10125111, Compound 3012)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(F)(F)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C29H24F7N3O5S/c1-37-27(41)24-21-13-20(17-4-3-5-18(12-17)26(40)38-15-28(32,33)29(34,35)36)22(39(11-10-30)45(2,42)43)14-23(21)44-25(24)16-6-8-19(31)9-7-16/h3-9,12-14H,10-11,15H2,1-2H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a 3.20n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298524
PNG
(US10125111, Compound 3023)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1[C@H](C)CC[C@H]1C)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33F2N3O5S/c1-19-8-9-20(2)37(19)32(39)23-7-5-6-22(16-23)25-17-26-28(18-27(25)36(15-14-33)43(4,40)41)42-30(29(26)31(38)35-3)21-10-12-24(34)13-11-21/h5-7,10-13,16-20H,8-9,14-15H2,1-4H3,(H,35,38)/t19-,20-/m1/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298527
PNG
(US10125111, Compound 3026)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1[C@@H](COC)CC[C@@H]1COC)-c1ccc(F)cc1
Show InChI InChI=1S/C34H37F2N3O7S/c1-37-33(40)31-28-17-27(22-6-5-7-23(16-22)34(41)39-25(19-44-2)12-13-26(39)20-45-3)29(38(15-14-35)47(4,42)43)18-30(28)46-32(31)21-8-10-24(36)11-9-21/h5-11,16-18,25-26H,12-15,19-20H2,1-4H3,(H,37,40)/t25-,26-/m1/s1
PDB

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n/an/an/an/a 332n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298528
PNG
(US10125111, Compound 3027)
Show SMILES CCC1CCCN1C(=O)c1cccc(c1)-c1cc2c(C(=O)NC)c(oc2cc1N(CCF)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C32H33F2N3O5S/c1-4-24-9-6-15-36(24)32(39)22-8-5-7-21(17-22)25-18-26-28(19-27(25)37(16-14-33)43(3,40)41)42-30(29(26)31(38)35-2)20-10-12-23(34)13-11-20/h5,7-8,10-13,17-19,24H,4,6,9,14-16H2,1-3H3,(H,35,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298529
PNG
(US10125111, Compound 3028)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCN(CC1)C(=O)OC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C35H38F2N4O7S/c1-35(2,3)48-34(44)40-17-15-39(16-18-40)33(43)24-8-6-7-23(19-24)26-20-27-29(21-28(26)41(14-13-36)49(5,45)46)47-31(30(27)32(42)38-4)22-9-11-25(37)12-10-22/h6-12,19-21H,13-18H2,1-5H3,(H,38,42)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298533
PNG
(US10125111, Compound 3032)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCN(CC1)c1cccnc1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H33F2N5O5S/c1-38-34(43)32-29-20-28(24-5-3-6-25(19-24)35(44)41-17-15-40(16-18-41)27-7-4-13-39-22-27)30(42(14-12-36)48(2,45)46)21-31(29)47-33(32)23-8-10-26(37)11-9-23/h3-11,13,19-22H,12,14-18H2,1-2H3,(H,38,43)
PDB

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n/an/an/an/a 2.64E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298539
PNG
(US10125111, Compound 3038)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CC[C@H](C1)NC(=O)OC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C35H38F2N4O7S/c1-35(2,3)48-34(44)39-25-13-15-40(20-25)33(43)23-8-6-7-22(17-23)26-18-27-29(19-28(26)41(16-14-36)49(5,45)46)47-31(30(27)32(42)38-4)21-9-11-24(37)12-10-21/h6-12,17-19,25H,13-16,20H2,1-5H3,(H,38,42)(H,39,44)/t25-/m1/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298553
PNG
(US10125111, Compound 4009)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C32H35F2N3O5S/c1-32(2,3)19-36-30(38)22-9-6-8-21(16-22)24-17-25-27(18-26(24)37(15-7-14-33)43(5,40)41)42-29(28(25)31(39)35-4)20-10-12-23(34)13-11-20/h6,8-13,16-18H,7,14-15,19H2,1-5H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298559
PNG
(US10125111, Compound 4015)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C31H33F2N3O5S/c1-19(2)18-35-30(37)22-8-5-7-21(15-22)24-16-25-27(17-26(24)36(14-6-13-32)42(4,39)40)41-29(28(25)31(38)34-3)20-9-11-23(33)12-10-20/h5,7-12,15-17,19H,6,13-14,18H2,1-4H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a 7.5n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298567
PNG
(US10125111, Compound 4023)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(CC1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C31H28F5N3O5S/c1-37-29(41)26-23-16-22(19-5-3-6-20(15-19)28(40)38-30(11-12-30)31(34,35)36)24(39(14-4-13-32)45(2,42)43)17-25(23)44-27(26)18-7-9-21(33)10-8-18/h3,5-10,15-17H,4,11-14H2,1-2H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298572
PNG
(US10125111, Compound 4028)
Show SMILES CCC(CC)(NC(=O)c1cccc(c1)-c1cc2c(C(=O)NC)c(oc2cc1N(CCCF)S(C)(=O)=O)-c1ccc(F)cc1)C#C
Show InChI InChI=1S/C34H35F2N3O5S/c1-6-34(7-2,8-3)38-32(40)24-12-9-11-23(19-24)26-20-27-29(21-28(26)39(18-10-17-35)45(5,42)43)44-31(30(27)33(41)37-4)22-13-15-25(36)16-14-22/h1,9,11-16,19-21H,7-8,10,17-18H2,2-5H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a 5.60n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298574
PNG
(US10125111, Compound 4030)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N[C@H](C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F5N3O5S/c1-17(30(33,34)35)37-28(39)20-7-4-6-19(14-20)22-15-23-25(16-24(22)38(13-5-12-31)44(3,41)42)43-27(26(23)29(40)36-2)18-8-10-21(32)11-9-18/h4,6-11,14-17H,5,12-13H2,1-3H3,(H,36,40)(H,37,39)/t17-/m1/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298580
PNG
(US10125111, Compound 6002)
Show SMILES CNC(=O)c1c(oc2cc(N(C(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C25H19F3N2O6S/c1-29-23(31)21-18-11-17(14-4-3-5-15(10-14)24(32)33)19(30(25(27)28)37(2,34)35)12-20(18)36-22(21)13-6-8-16(26)9-7-13/h3-12,25H,1-2H3,(H,29,31)(H,32,33)
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298586
PNG
(US10125111, Compound 7003)
Show SMILES CNC(=O)c1c(oc2cc(N(CC(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H27F6N3O5S/c1-29(2,30(34,35)36)38-27(40)18-7-5-6-17(12-18)20-13-21-23(14-22(20)39(15-24(32)33)45(4,42)43)44-26(25(21)28(41)37-3)16-8-10-19(31)11-9-16/h5-14,24H,15H2,1-4H3,(H,37,41)(H,38,40)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298506
PNG
(US10125111, Compound 3005)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F2N4O5S/c1-30(2,17-33)35-28(37)20-7-5-6-19(14-20)22-15-23-25(16-24(22)36(13-12-31)42(4,39)40)41-27(26(23)29(38)34-3)18-8-10-21(32)11-9-18/h5-11,14-16H,12-13H2,1-4H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a 5n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298516
PNG
(US10125111, Compound 3015)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C31H33F2N3O5S/c1-31(2,3)18-35-29(37)21-8-6-7-20(15-21)23-16-24-26(17-25(23)36(14-13-32)42(5,39)40)41-28(27(24)30(38)34-4)19-9-11-22(33)12-10-19/h6-12,15-17H,13-14,18H2,1-5H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298523
PNG
(US10125111, Compound 3022)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCCC1c1cccnc1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H32F2N4O5S/c1-38-34(42)32-28-19-27(23-6-3-7-24(18-23)35(43)40-16-5-9-29(40)25-8-4-15-39-21-25)30(41(17-14-36)47(2,44)45)20-31(28)46-33(32)22-10-12-26(37)13-11-22/h3-4,6-8,10-13,15,18-21,29H,5,9,14,16-17H2,1-2H3,(H,38,42)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298534
PNG
(US10125111, Compound 3033)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCN(CC(C)C)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H38F2N4O5S/c1-22(2)21-38-14-16-39(17-15-38)34(42)25-7-5-6-24(18-25)27-19-28-30(20-29(27)40(13-12-35)46(4,43)44)45-32(31(28)33(41)37-3)23-8-10-26(36)11-9-23/h5-11,18-20,22H,12-17,21H2,1-4H3,(H,37,41)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298540
PNG
(US10125111, Compound 3039)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)N1CCC(O)C1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H29F2N3O6S/c1-33-29(37)27-24-15-23(19-4-3-5-20(14-19)30(38)34-12-10-22(36)17-34)25(35(13-11-31)42(2,39)40)16-26(24)41-28(27)18-6-8-21(32)9-7-18/h3-9,14-16,22,36H,10-13,17H2,1-2H3,(H,33,37)
PDB

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n/an/an/an/a 1.61E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298556
PNG
(US10125111, Compound 4012)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C#C)-c1ccc(F)cc1
Show InChI InChI=1S/C32H31F2N3O5S/c1-6-32(2,3)36-30(38)22-10-7-9-21(17-22)24-18-25-27(19-26(24)37(16-8-15-33)43(5,40)41)42-29(28(25)31(39)35-4)20-11-13-23(34)14-12-20/h1,7,9-14,17-19H,8,15-16H2,2-5H3,(H,35,39)(H,36,38)
PDB

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n/an/an/an/a 8n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298560
PNG
(US10125111, Compound 4016)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC1(C)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31F2N3O5S/c1-31(12-13-31)35-29(37)21-7-4-6-20(16-21)23-17-24-26(18-25(23)36(15-5-14-32)42(3,39)40)41-28(27(24)30(38)34-2)19-8-10-22(33)11-9-19/h4,6-11,16-18H,5,12-15H2,1-3H3,(H,34,38)(H,35,37)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298561
PNG
(US10125111, Compound 4017)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(C)(C)CO)-c1ccc(F)cc1
Show InChI InChI=1S/C32H35F2N3O6S/c1-32(2,19-38)18-36-30(39)22-8-5-7-21(15-22)24-16-25-27(17-26(24)37(14-6-13-33)44(4,41)42)43-29(28(25)31(40)35-3)20-9-11-23(34)12-10-20/h5,7-12,15-17,38H,6,13-14,18-19H2,1-4H3,(H,35,40)(H,36,39)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298571
PNG
(US10125111, Compound 4027)
Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)CCO)-c1ccc(F)cc1
Show InChI InChI=1S/C32H35F2N3O6S/c1-32(2,13-16-38)36-30(39)22-8-5-7-21(17-22)24-18-25-27(19-26(24)37(15-6-14-33)44(4,41)42)43-29(28(25)31(40)35-3)20-9-11-23(34)12-10-20/h5,7-12,17-19,38H,6,13-16H2,1-4H3,(H,35,40)(H,36,39)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298576
PNG
(US10125111, Compound 5004)
Show SMILES CNC(=O)c1c(oc2cc(NCCCF)c(cc12)-c1cccc(c1)C(=O)NC(C)(C#N)C1CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H30F2N4O3/c1-32(18-35,22-9-10-22)38-30(39)21-6-3-5-20(15-21)24-16-25-27(17-26(24)37-14-4-13-33)41-29(28(25)31(40)36-2)19-7-11-23(34)12-8-19/h3,5-8,11-12,15-17,22,37H,4,9-10,13-14H2,1-2H3,(H,36,40)(H,38,39)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298577
PNG
(US10125111, Compound 5005)
Show SMILES CNC(=O)c1c(oc2cc(NCCCF)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H28F5N3O3/c1-29(2,30(33,34)35)38-27(39)19-7-4-6-18(14-19)21-15-22-24(16-23(21)37-13-5-12-31)41-26(25(22)28(40)36-3)17-8-10-20(32)11-9-17/h4,6-11,14-16,37H,5,12-13H2,1-3H3,(H,36,40)(H,38,39)
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298584
PNG
(US10125111, Compound 6006)
Show SMILES CNC(=O)c1c(oc2cc(N(C(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C29H28F3N3O5S/c1-29(2,3)34-26(36)18-8-6-7-17(13-18)20-14-21-23(15-22(20)35(28(31)32)41(5,38)39)40-25(24(21)27(37)33-4)16-9-11-19(30)12-10-16/h6-15,28H,1-5H3,(H,33,37)(H,34,36)
PDB

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n/an/an/an/a<100n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298590
PNG
(US10125111, Compound 9003)
Show SMILES CNC(=O)c1c(oc2cc(N(CCC(F)(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NCC(F)(F)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C30H24F9N3O5S/c1-40-27(44)24-21-13-20(17-4-3-5-18(12-17)26(43)41-15-28(32,33)30(37,38)39)22(42(48(2,45)46)11-10-29(34,35)36)14-23(21)47-25(24)16-6-8-19(31)9-7-16/h3-9,12-14H,10-11,15H2,1-2H3,(H,40,44)(H,41,43)
PDB

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n/an/an/an/a 7.60n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM298591
PNG
(US10125111, Compound 9004)
Show SMILES CNC(=O)c1c(oc2cc(N(CCC(F)(F)F)S(C)(=O)=O)c(cc12)-c1cccc(c1)C(=O)NC(C)(C)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C31H28F7N3O5S/c1-29(2,31(36,37)38)40-27(42)19-7-5-6-18(14-19)21-15-22-24(16-23(21)41(47(4,44)45)13-12-30(33,34)35)46-26(25(22)28(43)39-3)17-8-10-20(32)11-9-17/h5-11,14-16H,12-13H2,1-4H3,(H,39,43)(H,40,42)
PDB

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US Patent
n/an/an/an/a 10.6n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10125111 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%