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Patent code US10125144

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299173
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)pyrimidin-4-yl)-1H-...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H18N6O/c1-27-17-4-2-13-11-26(12-15(13)9-17)20-21-7-6-19(24-20)23-16-3-5-18-14(8-16)10-22-25-18/h2-10H,11-12H2,1H3,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299190
PNG
(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindol...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C22H20N6O/c1-29-20-7-4-16-13-28(14-17(16)10-20)22-23-9-8-21(27-22)26-19-5-2-15(3-6-19)18-11-24-25-12-18/h2-12H,13-14H2,1H3,(H,24,25)(H,23,26,27)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299188
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)-5,6-dimethylpyrimi...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc(C)c(C)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H22N6O/c1-13-14(2)24-22(28-11-15-4-6-19(29-3)9-17(15)12-28)26-21(13)25-18-5-7-20-16(8-18)10-23-27-20/h4-10H,11-12H2,1-3H3,(H,23,27)(H,24,25,26)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299179
PNG
(N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-5...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2COCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H20N6O2/c1-29-17-4-2-13-9-28(10-15(13)7-17)22-25-20-12-30-11-18(20)21(26-22)24-16-3-5-19-14(6-16)8-23-27-19/h2-8H,9-12H2,1H3,(H,23,27)(H,24,25,26)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299173
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)pyrimidin-4-yl)-1H-...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H18N6O/c1-27-17-4-2-13-11-26(12-15(13)9-17)20-21-7-6-19(24-20)23-16-3-5-18-14(8-16)10-22-25-18/h2-10H,11-12H2,1H3,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299175
PNG
(N-(5-Fluoro-2-(5-methoxyisoindolin-2-yl)pyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1ncc(F)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H17FN6O/c1-28-16-4-2-12-10-27(11-14(12)7-16)20-22-9-17(21)19(25-20)24-15-3-5-18-13(6-15)8-23-26-18/h2-9H,10-11H2,1H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299178
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)-6-methylpyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc(C)cc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H20N6O/c1-13-7-20(24-17-4-6-19-15(8-17)10-22-26-19)25-21(23-13)27-11-14-3-5-18(28-2)9-16(14)12-27/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299192
PNG
(2-(5-Methoxyisoindolin-2-yl)-N-(4-(pyridin-4-yl)ph...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1
Show InChI InChI=1S/C24H21N5O/c1-30-22-7-4-19-15-29(16-20(19)14-22)24-26-13-10-23(28-24)27-21-5-2-17(3-6-21)18-8-11-25-12-9-18/h2-14H,15-16H2,1H3,(H,26,27,28)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299192
PNG
(2-(5-Methoxyisoindolin-2-yl)-N-(4-(pyridin-4-yl)ph...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1
Show InChI InChI=1S/C24H21N5O/c1-30-22-7-4-19-15-29(16-20(19)14-22)24-26-13-10-23(28-24)27-21-5-2-17(3-6-21)18-8-11-25-12-9-18/h2-14H,15-16H2,1H3,(H,26,27,28)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299181
PNG
(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Show SMILES Fc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H15FN6/c20-15-2-1-12-10-26(11-14(12)7-15)19-21-6-5-18(24-19)23-16-3-4-17-13(8-16)9-22-25-17/h1-9H,10-11H2,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299177
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)-5-methylpyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1ncc(C)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H20N6O/c1-13-9-22-21(27-11-14-3-5-18(28-2)8-16(14)12-27)25-20(13)24-17-4-6-19-15(7-17)10-23-26-19/h3-10H,11-12H2,1-2H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299174
PNG
(N-(2-(Isoindolin-2-yl)pyrimidin-4-yl)-1H-indazol-5...)
Show SMILES C1N(Cc2ccccc12)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H16N6/c1-2-4-14-12-25(11-13(14)3-1)19-20-8-7-18(23-19)22-16-5-6-17-15(9-16)10-21-24-17/h1-10H,11-12H2,(H,21,24)(H,20,22,23)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299199
PNG
(N-(2-(4-Methoxyisoindolin-2-yl)pyrimidin-4-yl)-1H-...)
Show SMILES COc1cccc2CN(Cc12)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H18N6O/c1-27-18-4-2-3-13-11-26(12-16(13)18)20-21-8-7-19(24-20)23-15-5-6-17-14(9-15)10-22-25-17/h2-10H,11-12H2,1H3,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299198
PNG
(N-(2-(5-(Methoxymethyl)isoindolin-2-yl)pyrimidin-4...)
Show SMILES COCc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H20N6O/c1-28-13-14-2-3-15-11-27(12-17(15)8-14)21-22-7-6-20(25-21)24-18-4-5-19-16(9-18)10-23-26-19/h2-10H,11-13H2,1H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299182
PNG
(N-(2-(5-Chloroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Show SMILES Clc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H15ClN6/c20-15-2-1-12-10-26(11-14(12)7-15)19-21-6-5-18(24-19)23-16-3-4-17-13(8-16)9-22-25-17/h1-9H,10-11H2,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299197
PNG
(2-(4-((1H-Indazol-5-yl)amino)pyrimidin-2-yl)isoind...)
Show SMILES N#Cc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H15N7/c21-9-13-1-2-14-11-27(12-16(14)7-13)20-22-6-5-19(25-20)24-17-3-4-18-15(8-17)10-23-26-18/h1-8,10H,11-12H2,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299196
PNG
(N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-7...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CN(C)CCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H25N7O/c1-30-8-7-20-22(14-30)27-24(31-12-15-3-5-19(32-2)10-17(15)13-31)28-23(20)26-18-4-6-21-16(9-18)11-25-29-21/h3-6,9-11H,7-8,12-14H2,1-2H3,(H,25,29)(H,26,27,28)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299185
PNG
(N-(6-(5-Methoxyisoindolin-2-yl)pyrimidin-4-yl)-1H-...)
Show SMILES COc1ccc2CN(Cc2c1)c1cc(Nc2ccc3[nH]ncc3c2)ncn1
Show InChI InChI=1S/C20H18N6O/c1-27-17-4-2-13-10-26(11-15(13)7-17)20-8-19(21-12-22-20)24-16-3-5-18-14(6-16)9-23-25-18/h2-9,12H,10-11H2,1H3,(H,23,25)(H,21,22,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299176
PNG
(N-(5-Chloro-2-(5-methoxyisoindolin-2-yl)pyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1ncc(Cl)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H17ClN6O/c1-28-16-4-2-12-10-27(11-14(12)7-16)20-22-9-17(21)19(25-20)24-15-3-5-18-13(6-15)8-23-26-18/h2-9H,10-11H2,1H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299186
PNG
(N-(6-(5-Methoxyisoindolin-2-yl)-2-methylpyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1cc(Nc2ccc3[nH]ncc3c2)nc(C)n1
Show InChI InChI=1S/C21H20N6O/c1-13-23-20(25-17-4-6-19-15(7-17)10-22-26-19)9-21(24-13)27-11-14-3-5-18(28-2)8-16(14)12-27/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299193
PNG
(N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-7...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CCOCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H22N6O2/c1-30-18-4-2-14-11-29(12-16(14)9-18)23-26-21-6-7-31-13-19(21)22(27-23)25-17-3-5-20-15(8-17)10-24-28-20/h2-5,8-10H,6-7,11-13H2,1H3,(H,24,28)(H,25,26,27)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299176
PNG
(N-(5-Chloro-2-(5-methoxyisoindolin-2-yl)pyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1ncc(Cl)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H17ClN6O/c1-28-16-4-2-12-10-27(11-14(12)7-16)20-22-9-17(21)19(25-20)24-15-3-5-18-13(6-15)8-23-26-18/h2-9H,10-11H2,1H3,(H,23,26)(H,22,24,25)
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n/an/a 190n/an/an/an/an/an/a



KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299187
PNG
(N-(2-(1H-Pyrrolo[3,4-c]pyridin-2(3H)-yl)pyrimidin-...)
Show SMILES C1N(Cc2cnccc12)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C18H15N7/c1-2-16-13(9-21-24-16)7-15(1)22-17-4-6-20-18(23-17)25-10-12-3-5-19-8-14(12)11-25/h1-9H,10-11H2,(H,21,24)(H,20,22,23)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299173
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)pyrimidin-4-yl)-1H-...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H18N6O/c1-27-17-4-2-13-11-26(12-15(13)9-17)20-21-7-6-19(24-20)23-16-3-5-18-14(8-16)10-22-25-18/h2-10H,11-12H2,1H3,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299202
PNG
(N-(2-(Isoindolin-2-yl)-5,6-dimethoxypyrimidin-4-yl...)
Show SMILES COc1nc(nc(Nc2ccc3[nH]ncc3c2)c1OC)N1Cc2ccccc2C1
Show InChI InChI=1S/C21H20N6O2/c1-28-18-19(23-16-7-8-17-15(9-16)10-22-26-17)24-21(25-20(18)29-2)27-11-13-5-3-4-6-14(13)12-27/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299183
PNG
(N-(2-(6-Methoxy-3,4-dihydroisoquinolin-2(1H)-yl)py...)
Show SMILES COc1ccc2CN(CCc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H20N6O/c1-28-18-4-2-15-13-27(9-7-14(15)11-18)21-22-8-6-20(25-21)24-17-3-5-19-16(10-17)12-23-26-19/h2-6,8,10-12H,7,9,13H2,1H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299200
PNG
(N-(2-(4-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Show SMILES Fc1cccc2CN(Cc12)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H15FN6/c20-16-3-1-2-12-10-26(11-15(12)16)19-21-7-6-18(24-19)23-14-4-5-17-13(8-14)9-22-25-17/h1-9H,10-11H2,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299173
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)pyrimidin-4-yl)-1H-...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H18N6O/c1-27-17-4-2-13-11-26(12-15(13)9-17)20-21-7-6-19(24-20)23-16-3-5-18-14(8-16)10-22-25-18/h2-10H,11-12H2,1H3,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299184
PNG
(N-(2-(6,7-Dihydrothieno[3,2-c]pyridin-5(4H)-yl)pyr...)
Show SMILES C1Cc2sccc2CN1c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C18H16N6S/c1-2-15-13(10-20-23-15)9-14(1)21-17-3-6-19-18(22-17)24-7-4-16-12(11-24)5-8-25-16/h1-3,5-6,8-10H,4,7,11H2,(H,20,23)(H,19,21,22)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299180
PNG
(N-(4-(5-Methoxyisoindolin-2-yl)pyrimidin-2-yl)-1H-...)
Show SMILES COc1ccc2CN(Cc2c1)c1ccnc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H18N6O/c1-27-17-4-2-13-11-26(12-15(13)9-17)19-6-7-21-20(24-19)23-16-3-5-18-14(8-16)10-22-25-18/h2-10H,11-12H2,1H3,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299178
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)-6-methylpyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc(C)cc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H20N6O/c1-13-7-20(24-17-4-6-19-15(8-17)10-22-26-19)25-21(23-13)27-11-14-3-5-18(28-2)9-16(14)12-27/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299195
PNG
(N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-5...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CNCCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H23N7O/c1-31-18-4-2-14-12-30(13-16(14)9-18)23-27-21-11-24-7-6-19(21)22(28-23)26-17-3-5-20-15(8-17)10-25-29-20/h2-5,8-10,24H,6-7,11-13H2,1H3,(H,25,29)(H,26,27,28)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299181
PNG
(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Show SMILES Fc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H15FN6/c20-15-2-1-12-10-26(11-14(12)7-15)19-21-6-5-18(24-19)23-16-3-4-17-13(8-16)9-22-25-17/h1-9H,10-11H2,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299194
PNG
((KL-00254) N-(1H-Indazol-5-yl)-2-(5-methoxyisoindo...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CNCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H21N7O/c1-30-17-4-2-13-11-29(12-15(13)7-17)22-26-20-10-23-9-18(20)21(27-22)25-16-3-5-19-14(6-16)8-24-28-19/h2-8,23H,9-12H2,1H3,(H,24,28)(H,25,26,27)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299179
PNG
(N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-5...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2COCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H20N6O2/c1-29-17-4-2-13-9-28(10-15(13)7-17)22-25-20-12-30-11-18(20)21(26-22)24-16-3-5-19-14(6-16)8-23-27-19/h2-8H,9-12H2,1H3,(H,23,27)(H,24,25,26)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299198
PNG
(N-(2-(5-(Methoxymethyl)isoindolin-2-yl)pyrimidin-4...)
Show SMILES COCc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H20N6O/c1-28-13-14-2-3-15-11-27(12-17(15)8-14)21-22-7-6-20(25-21)24-18-4-5-19-16(9-18)10-23-26-19/h2-10H,11-13H2,1H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299175
PNG
(N-(5-Fluoro-2-(5-methoxyisoindolin-2-yl)pyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1ncc(F)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H17FN6O/c1-28-16-4-2-12-10-27(11-14(12)7-16)20-22-9-17(21)19(25-20)24-15-3-5-18-13(6-15)8-23-26-18/h2-9H,10-11H2,1H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299177
PNG
(N-(2-(5-Methoxyisoindolin-2-yl)-5-methylpyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1ncc(C)c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H20N6O/c1-13-9-22-21(27-11-14-3-5-18(28-2)8-16(14)12-27)25-20(13)24-17-4-6-19-15(7-17)10-23-26-19/h3-10H,11-12H2,1-2H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299192
PNG
(2-(5-Methoxyisoindolin-2-yl)-N-(4-(pyridin-4-yl)ph...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1
Show InChI InChI=1S/C24H21N5O/c1-30-22-7-4-19-15-29(16-20(19)14-22)24-26-13-10-23(28-24)27-21-5-2-17(3-6-21)18-8-11-25-12-9-18/h2-14H,15-16H2,1H3,(H,26,27,28)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299184
PNG
(N-(2-(6,7-Dihydrothieno[3,2-c]pyridin-5(4H)-yl)pyr...)
Show SMILES C1Cc2sccc2CN1c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C18H16N6S/c1-2-15-13(10-20-23-15)9-14(1)21-17-3-6-19-18(22-17)24-7-4-16-12(11-24)5-8-25-16/h1-3,5-6,8-10H,4,7,11H2,(H,20,23)(H,19,21,22)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299185
PNG
(N-(6-(5-Methoxyisoindolin-2-yl)pyrimidin-4-yl)-1H-...)
Show SMILES COc1ccc2CN(Cc2c1)c1cc(Nc2ccc3[nH]ncc3c2)ncn1
Show InChI InChI=1S/C20H18N6O/c1-27-17-4-2-13-10-26(11-15(13)7-17)20-8-19(21-12-22-20)24-16-3-5-18-14(6-16)9-23-25-18/h2-9,12H,10-11H2,1H3,(H,23,25)(H,21,22,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299194
PNG
((KL-00254) N-(1H-Indazol-5-yl)-2-(5-methoxyisoindo...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CNCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H21N7O/c1-30-17-4-2-13-11-29(12-15(13)7-17)22-26-20-10-23-9-18(20)21(27-22)25-16-3-5-19-14(6-16)8-24-28-19/h2-8,23H,9-12H2,1H3,(H,24,28)(H,25,26,27)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299182
PNG
(N-(2-(5-Chloroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Show SMILES Clc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H15ClN6/c20-15-2-1-12-10-26(11-14(12)7-15)19-21-6-5-18(24-19)23-16-3-4-17-13(8-16)9-22-25-17/h1-9H,10-11H2,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299180
PNG
(N-(4-(5-Methoxyisoindolin-2-yl)pyrimidin-2-yl)-1H-...)
Show SMILES COc1ccc2CN(Cc2c1)c1ccnc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H18N6O/c1-27-17-4-2-13-11-26(12-15(13)9-17)19-6-7-21-20(24-19)23-16-3-5-18-14(8-16)10-22-25-18/h2-10H,11-12H2,1H3,(H,22,25)(H,21,23,24)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299192
PNG
(2-(5-Methoxyisoindolin-2-yl)-N-(4-(pyridin-4-yl)ph...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1
Show InChI InChI=1S/C24H21N5O/c1-30-22-7-4-19-15-29(16-20(19)14-22)24-26-13-10-23(28-24)27-21-5-2-17(3-6-21)18-8-11-25-12-9-18/h2-14H,15-16H2,1H3,(H,26,27,28)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299196
PNG
(N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-7...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CN(C)CCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H25N7O/c1-30-8-7-20-22(14-30)27-24(31-12-15-3-5-19(32-2)10-17(15)13-31)28-23(20)26-18-4-6-21-16(9-18)11-25-29-21/h3-6,9-11H,7-8,12-14H2,1-2H3,(H,25,29)(H,26,27,28)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299202
PNG
(N-(2-(Isoindolin-2-yl)-5,6-dimethoxypyrimidin-4-yl...)
Show SMILES COc1nc(nc(Nc2ccc3[nH]ncc3c2)c1OC)N1Cc2ccccc2C1
Show InChI InChI=1S/C21H20N6O2/c1-28-18-19(23-16-7-8-17-15(9-16)10-22-26-17)24-21(25-20(18)29-2)27-11-13-5-3-4-6-14(13)12-27/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299174
PNG
(N-(2-(Isoindolin-2-yl)pyrimidin-4-yl)-1H-indazol-5...)
Show SMILES C1N(Cc2ccccc12)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C19H16N6/c1-2-4-14-12-25(11-13(14)3-1)19-20-8-7-18(23-19)22-16-5-6-17-15(9-16)10-21-24-17/h1-10H,11-12H2,(H,21,24)(H,20,22,23)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299201
PNG
(2-(5-Fluoroisoindolin-2-yl)-N-(1H-indazol-5-yl)-5,...)
Show SMILES Fc1ccc2CN(Cc2c1)c1nc2COCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H17FN6O/c22-15-2-1-12-8-28(9-14(12)5-15)21-25-19-11-29-10-17(19)20(26-21)24-16-3-4-18-13(6-16)7-23-27-18/h1-7H,8-11H2,(H,23,27)(H,24,25,26)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299183
PNG
(N-(2-(6-Methoxy-3,4-dihydroisoquinolin-2(1H)-yl)py...)
Show SMILES COc1ccc2CN(CCc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H20N6O/c1-28-18-4-2-15-13-27(9-7-14(15)11-18)21-22-8-6-20(25-21)24-17-3-5-19-16(10-17)12-23-26-19/h2-6,8,10-12H,7,9,13H2,1H3,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299190
PNG
(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(5-methoxyisoindol...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C22H20N6O/c1-29-20-7-4-16-13-28(14-17(16)10-20)22-23-9-8-21(27-22)26-19-5-2-15(3-6-19)18-11-24-25-12-18/h2-12H,13-14H2,1H3,(H,24,25)(H,23,26,27)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299193
PNG
(N-(1H-Indazol-5-yl)-2-(5-methoxyisoindolin-2-yl)-7...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CCOCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H22N6O2/c1-30-18-4-2-14-11-29(12-16(14)9-18)23-26-21-6-7-31-13-19(21)22(27-23)25-17-3-5-20-15(8-17)10-24-28-20/h2-5,8-10H,6-7,11-13H2,1H3,(H,24,28)(H,25,26,27)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299197
PNG
(2-(4-((1H-Indazol-5-yl)amino)pyrimidin-2-yl)isoind...)
Show SMILES N#Cc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C20H15N7/c21-9-13-1-2-14-11-27(12-16(14)7-13)20-22-6-5-19(25-20)24-17-3-4-18-15(8-17)10-23-26-18/h1-8,10H,11-12H2,(H,23,26)(H,22,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299191
PNG
(2-(5-Methoxyisoindolin-2-yl)-N-(pyridin-4-yl)pyrim...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccncc2)n1
Show InChI InChI=1S/C18H17N5O/c1-24-16-3-2-13-11-23(12-14(13)10-16)18-20-9-6-17(22-18)21-15-4-7-19-8-5-15/h2-10H,11-12H2,1H3,(H,19,20,21,22)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299191
PNG
(2-(5-Methoxyisoindolin-2-yl)-N-(pyridin-4-yl)pyrim...)
Show SMILES COc1ccc2CN(Cc2c1)c1nccc(Nc2ccncc2)n1
Show InChI InChI=1S/C18H17N5O/c1-24-16-3-2-13-11-23(12-14(13)10-16)18-20-9-6-17(22-18)21-15-4-7-19-8-5-15/h2-10H,11-12H2,1H3,(H,19,20,21,22)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299187
PNG
(N-(2-(1H-Pyrrolo[3,4-c]pyridin-2(3H)-yl)pyrimidin-...)
Show SMILES C1N(Cc2cnccc12)c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C18H15N7/c1-2-16-13(9-21-24-16)7-15(1)22-17-4-6-20-18(23-17)25-10-12-3-5-19-8-14(12)11-25/h1-9H,10-11H2,(H,21,24)(H,20,22,23)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299186
PNG
(N-(6-(5-Methoxyisoindolin-2-yl)-2-methylpyrimidin-...)
Show SMILES COc1ccc2CN(Cc2c1)c1cc(Nc2ccc3[nH]ncc3c2)nc(C)n1
Show InChI InChI=1S/C21H20N6O/c1-13-23-20(25-17-4-6-19-15(7-17)10-22-26-19)9-21(24-13)27-11-14-3-5-18(28-2)8-16(14)12-27/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (human))
BDBM299189
PNG
(N-(1H-Indazol-5-yl)-2-(isoindolin-2-yl)-5,7-dihydr...)
Show SMILES C1OCc2c1nc(nc2Nc1ccc2[nH]ncc2c1)N1Cc2ccccc2C1
Show InChI InChI=1S/C21H18N6O/c1-2-4-14-10-27(9-13(14)3-1)21-24-19-12-28-11-17(19)20(25-21)23-16-5-6-18-15(7-16)8-22-26-18/h1-8H,9-12H2,(H,22,26)(H,23,24,25)
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KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299194
PNG
((KL-00254) N-(1H-Indazol-5-yl)-2-(5-methoxyisoindo...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CNCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H21N7O/c1-30-17-4-2-13-11-29(12-15(13)7-17)22-26-20-10-23-9-18(20)21(27-22)25-16-3-5-19-14(6-16)8-24-28-19/h2-8,23H,9-12H2,1H3,(H,24,28)(H,25,26,27)
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n/an/a 2.40E+4n/an/an/an/an/an/a



KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM299194
PNG
((KL-00254) N-(1H-Indazol-5-yl)-2-(5-methoxyisoindo...)
Show SMILES COc1ccc2CN(Cc2c1)c1nc2CNCc2c(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H21N7O/c1-30-17-4-2-13-11-29(12-15(13)7-17)22-26-20-10-23-9-18(20)21(27-22)25-16-3-5-19-14(6-16)8-24-28-19/h2-8,23H,9-12H2,1H3,(H,24,28)(H,25,26,27)
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n/an/a 2.43E+4n/an/an/an/an/an/a



KADMON CORPORATION, LLC

US Patent


Assay Description
Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...


US Patent US10125144 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%