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Patent code US10130633

Compile Data Set for Download or QSAR

Found 700 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Wnt-3a


(Homo sapiens)
BDBM300557
PNG
(N-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-[(m...)
Show SMILES Fc1ccccc1-c1nnc(s1)C(=O)Nc1ccc(OC(F)(F)F)c(NC(=O)CN2CCOCC2)c1
Show InChI InChI=1S/C22H19F4N5O4S/c23-15-4-2-1-3-14(15)20-29-30-21(36-20)19(33)27-13-5-6-17(35-22(24,25)26)16(11-13)28-18(32)12-31-7-9-34-10-8-31/h1-6,11H,7-10,12H2,(H,27,33)(H,28,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300559
PNG
(3-{[2-(4-methylpiperazin-1-yl)propanoyl]amino}-N-(...)
Show SMILES CC(N1CCN(C)CC1)C(=O)Nc1cc(ccc1C(F)(F)F)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C24H25F3N6O2S/c1-15(33-12-10-32(2)11-13-33)20(34)28-19-14-17(8-9-18(19)24(25,26)27)21(35)29-23-31-30-22(36-23)16-6-4-3-5-7-16/h3-9,14-15H,10-13H2,1-2H3,(H,28,34)(H,29,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300563
PNG
(4-(cyclopropyloxy)-N-[6-(2-fluorophenyl)pyridin-3-...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)c2ccc(OC3CC3)c(NC(=O)CN3CCOCC3)c2)cn1
Show InChI InChI=1S/C27H27FN4O4/c28-22-4-2-1-3-21(22)23-9-6-19(16-29-23)30-27(34)18-5-10-25(36-20-7-8-20)24(15-18)31-26(33)17-32-11-13-35-14-12-32/h1-6,9-10,15-16,20H,7-8,11-14,17H2,(H,30,34)(H,31,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300597
PNG
(3-{[(2,4-dimethylpiperazin-1-yl)acetyl]amino}-N-(5...)
Show SMILES CC1CN(C)CCN1CC(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C24H25F3N6O3S/c1-15-13-32(2)10-11-33(15)14-20(34)28-18-12-17(8-9-19(18)36-24(25,26)27)21(35)29-23-31-30-22(37-23)16-6-4-3-5-7-16/h3-9,12,15H,10-11,13-14H2,1-2H3,(H,28,34)(H,29,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300626
PNG
(3-{[2-(4-cyclopropylpiperazin-1- yl)propanoyl]amin...)
Show SMILES CC(N1CCN(CC1)C1CC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1ccccc1F
Show InChI InChI=1S/C29H29F4N5O3/c1-18(37-12-14-38(15-13-37)21-8-9-21)27(39)36-25-16-19(6-11-26(25)41-29(31,32)33)28(40)35-20-7-10-24(34-17-20)22-4-2-3-5-23(22)30/h2-7,10-11,16-18,21H,8-9,12-15H2,1H3,(H,35,40)(H,36,39)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300661
PNG
(3-{[2-(4-methylpiperazin-1- yl)propanoyl]amino}-4-...)
Show SMILES CC(N1CCN(C)CC1)C(=O)Nc1cc(ccc1CS(C)(=O)=O)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C25H30N6O4S2/c1-17(31-13-11-30(2)12-14-31)22(32)26-21-15-19(9-10-20(21)16-37(3,34)35)23(33)27-25-29-28-24(36-25)18-7-5-4-6-8-18/h4-10,15,17H,11-14,16H2,1-3H3,(H,26,32)(H,27,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300684
PNG
(3-{[(1S,4S)-2-oxa-5- azabicyclo[2.2.1]hept-5- ylac...)
Show SMILES FC(F)(F)Oc1ccc(cc1NC(=O)CN1C[C@@H]2C[C@H]1CO2)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C23H20F3N5O4S/c24-23(25,26)35-18-7-6-14(8-17(18)27-19(32)11-31-10-16-9-15(31)12-34-16)20(33)28-22-30-29-21(36-22)13-4-2-1-3-5-13/h1-8,15-16H,9-12H2,(H,27,32)(H,28,30,33)/t15-,16-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300697
PNG
(N-[5-(3-cyanophenyl)-1,3,4- thiadiazol-2-yl]-3-{[(...)
Show SMILES CN1CCN(CC(=O)Nc2cc(ccc2OC(F)(F)F)C(=O)Nc2nnc(s2)-c2cccc(c2)C#N)CC1
Show InChI InChI=1S/C24H22F3N7O3S/c1-33-7-9-34(10-8-33)14-20(35)29-18-12-16(5-6-19(18)37-24(25,26)27)21(36)30-23-32-31-22(38-23)17-4-2-3-15(11-17)13-28/h2-6,11-12H,7-10,14H2,1H3,(H,29,35)(H,30,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300445
PNG
(3-[(morpholin-4-ylacetyl)amino]-N-(6-phenylpyridin...)
Show SMILES FC(F)(F)Oc1ccc(cc1NC(=O)CN1CCOCC1)C(=O)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C25H23F3N4O4/c26-25(27,28)36-22-9-6-18(14-21(22)31-23(33)16-32-10-12-35-13-11-32)24(34)30-19-7-8-20(29-15-19)17-4-2-1-3-5-17/h1-9,14-15H,10-13,16H2,(H,30,34)(H,31,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300470
PNG
(4-(difluoromethoxy)-3-{[(4-methylpiperazin-1-yl)ac...)
Show SMILES CN1CCN(CC(=O)Nc2cc(ccc2OC(F)F)C(=O)Nc2nnc(s2)-c2ccccc2)CC1
Show InChI InChI=1S/C23H24F2N6O3S/c1-30-9-11-31(12-10-30)14-19(32)26-17-13-16(7-8-18(17)34-22(24)25)20(33)27-23-29-28-21(35-23)15-5-3-2-4-6-15/h2-8,13,22H,9-12,14H2,1H3,(H,26,32)(H,27,29,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300472
PNG
(4-(difluoromethoxy)-3-{[2-(4-methylpiperazin-1-yl)...)
Show SMILES CC(N1CCN(C)CC1)C(=O)Nc1cc(ccc1OC(F)F)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C24H26F2N6O3S/c1-15(32-12-10-31(2)11-13-32)20(33)27-18-14-17(8-9-19(18)35-23(25)26)21(34)28-24-30-29-22(36-24)16-6-4-3-5-7-16/h3-9,14-15,23H,10-13H2,1-2H3,(H,27,33)(H,28,30,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300483
PNG
(3-{[(4-cyclopropylpiperazin-1-yl)acetyl]amino}-N-(...)
Show SMILES FC(F)(F)Oc1ccc(cc1NC(=O)CN1CCN(CC1)C1CC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C25H25F3N6O3S/c26-25(27,28)37-20-9-6-17(22(36)30-24-32-31-23(38-24)16-4-2-1-3-5-16)14-19(20)29-21(35)15-33-10-12-34(13-11-33)18-7-8-18/h1-6,9,14,18H,7-8,10-13,15H2,(H,29,35)(H,30,32,36)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300488
PNG
(3-{[2-(4-methylpiperazin-1-yl)propanoyl]amino}-N-(...)
Show SMILES CC(N1CCN(C)CC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C24H25F3N6O3S/c1-15(33-12-10-32(2)11-13-33)20(34)28-18-14-17(8-9-19(18)36-24(25,26)27)21(35)29-23-31-30-22(37-23)16-6-4-3-5-7-16/h3-9,14-15H,10-13H2,1-2H3,(H,28,34)(H,29,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300495
PNG
(N-[6-(2-fluorophenyl)pyridin-3-yl]-3-{[(2S)-2-(4-m...)
Show SMILES C[C@@H](N1CCN(C)CC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1ccccc1F
Show InChI InChI=1S/C27H27F4N5O3/c1-17(36-13-11-35(2)12-14-36)25(37)34-23-15-18(7-10-24(23)39-27(29,30)31)26(38)33-19-8-9-22(32-16-19)20-5-3-4-6-21(20)28/h3-10,15-17H,11-14H2,1-2H3,(H,33,38)(H,34,37)/t17-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300541
PNG
(N-[6-(4-aminophenyl)pyridin-3-yl]-3-{[2-(morpholin...)
Show SMILES CC(N1CCOCC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1ccc(N)cc1
Show InChI InChI=1S/C26H26F3N5O4/c1-16(34-10-12-37-13-11-34)24(35)33-22-14-18(4-9-23(22)38-26(27,28)29)25(36)32-20-7-8-21(31-15-20)17-2-5-19(30)6-3-17/h2-9,14-16H,10-13,30H2,1H3,(H,32,36)(H,33,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300443
PNG
(3-[(morpholin-4-ylacetyl)amino]-N-(6-phenylpyridin...)
Show SMILES FC(F)(F)c1ccc(cc1NC(=O)CN1CCOCC1)C(=O)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C25H23F3N4O3/c26-25(27,28)20-8-6-18(14-22(20)31-23(33)16-32-10-12-35-13-11-32)24(34)30-19-7-9-21(29-15-19)17-4-2-1-3-5-17/h1-9,14-15H,10-13,16H2,(H,30,34)(H,31,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300460
PNG
(6-(2-fluorophenyl)-N-{3-[(morpholin-4-ylacetyl)ami...)
Show SMILES Fc1ccccc1-c1ccc(cn1)C(=O)Nc1ccc(OC(F)(F)F)c(NC(=O)CN2CCOCC2)c1
Show InChI InChI=1S/C25H22F4N4O4/c26-19-4-2-1-3-18(19)20-7-5-16(14-30-20)24(35)31-17-6-8-22(37-25(27,28)29)21(13-17)32-23(34)15-33-9-11-36-12-10-33/h1-8,13-14H,9-12,15H2,(H,31,35)(H,32,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300481
PNG
(3-({[1-(4-cyclopropylpiperazin-1-yl)cyclopropyl]ca...)
Show SMILES FC(F)(F)Oc1ccc(cc1NC(=O)C1(CC1)N1CCN(CC1)C1CC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C27H27F3N6O3S/c28-27(29,30)39-21-9-6-18(22(37)32-25-34-33-23(40-25)17-4-2-1-3-5-17)16-20(21)31-24(38)26(10-11-26)36-14-12-35(13-15-36)19-7-8-19/h1-6,9,16,19H,7-8,10-15H2,(H,31,38)(H,32,34,37)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300482
PNG
(3-({[1-(4-methylpiperazin-1-yl)cyclopropyl]carbony...)
Show SMILES CN1CCN(CC1)C1(CC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C25H25F3N6O3S/c1-33-11-13-34(14-12-33)24(9-10-24)22(36)29-18-15-17(7-8-19(18)37-25(26,27)28)20(35)30-23-32-31-21(38-23)16-5-3-2-4-6-16/h2-8,15H,9-14H2,1H3,(H,29,36)(H,30,32,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300486
PNG
(2-({[1-(morpholin-4-yl)cyclopropyl]carbonyl}amino)...)
Show SMILES NC(=O)c1ccc(cc1NC(=O)C1(CC1)N1CCOCC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O4S/c25-19(31)17-7-6-16(20(32)27-23-29-28-21(35-23)15-4-2-1-3-5-15)14-18(17)26-22(33)24(8-9-24)30-10-12-34-13-11-30/h1-7,14H,8-13H2,(H2,25,31)(H,26,33)(H,27,29,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300487
PNG
(3-{[2-(morpholin-4-yl)propanoyl]amino}-N-(5-phenyl...)
Show SMILES CC(N1CCOCC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C23H22F3N5O4S/c1-14(31-9-11-34-12-10-31)19(32)27-17-13-16(7-8-18(17)35-23(24,25)26)20(33)28-22-30-29-21(36-22)15-5-3-2-4-6-15/h2-8,13-14H,9-12H2,1H3,(H,27,32)(H,28,30,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300509
PNG
(4-chloro-N-[6-(2-fluorophenyl)pyridin-3-yl]-3-({[1...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)c2ccc(Cl)c(NC(=O)C3(CC3)N3CCOCC3)c2)cn1
Show InChI InChI=1S/C26H24ClFN4O3/c27-20-7-5-17(15-23(20)31-25(34)26(9-10-26)32-11-13-35-14-12-32)24(33)30-18-6-8-22(29-16-18)19-3-1-2-4-21(19)28/h1-8,15-16H,9-14H2,(H,30,33)(H,31,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300531
PNG
(N-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-{[...)
Show SMILES COc1ccccc1-c1nnc(NC(=O)c2ccc(OC(F)(F)F)c(NC(=O)CN3CCN(C)CC3)c2)s1
Show InChI InChI=1S/C24H25F3N6O4S/c1-32-9-11-33(12-10-32)14-20(34)28-17-13-15(7-8-19(17)37-24(25,26)27)21(35)29-23-31-30-22(38-23)16-5-3-4-6-18(16)36-2/h3-8,13H,9-12,14H2,1-2H3,(H,28,34)(H,29,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300549
PNG
(N-{6-[4-(hydroxymethyl)phenyl]pyridin-3-yl}-3-{[(2...)
Show SMILES C[C@@H](N1CCOCC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1ccc(CO)cc1
Show InChI InChI=1S/C27H27F3N4O5/c1-17(34-10-12-38-13-11-34)25(36)33-23-14-20(6-9-24(23)39-27(28,29)30)26(37)32-21-7-8-22(31-15-21)19-4-2-18(16-35)3-5-19/h2-9,14-15,17,35H,10-13,16H2,1H3,(H,32,37)(H,33,36)/t17-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300552
PNG
(3-[(morpholin-4-ylacetyl)amino]-N-(2-phenyl-1,3-th...)
Show SMILES FC(F)(F)Oc1ccc(cc1NC(=O)CN1CCOCC1)C(=O)Nc1cnc(s1)-c1ccccc1
Show InChI InChI=1S/C23H21F3N4O4S/c24-23(25,26)34-18-7-6-16(12-17(18)28-19(31)14-30-8-10-33-11-9-30)21(32)29-20-13-27-22(35-20)15-4-2-1-3-5-15/h1-7,12-13H,8-11,14H2,(H,28,31)(H,29,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300555
PNG
(3-[(morpholin-4-ylacetyl)amino]-N-(3-phenyl-1,2,4-...)
Show SMILES FC(F)(F)Oc1ccc(cc1NC(=O)CN1CCOCC1)C(=O)Nc1nc(no1)-c1ccccc1
Show InChI InChI=1S/C22H20F3N5O5/c23-22(24,25)34-17-7-6-15(12-16(17)26-18(31)13-30-8-10-33-11-9-30)20(32)28-21-27-19(29-35-21)14-4-2-1-3-5-14/h1-7,12H,8-11,13H2,(H,26,31)(H,27,28,29,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300560
PNG
(N-{4-methoxy-3-[(morpholin-4-ylacetyl)amino]phenyl...)
Show SMILES COc1ccc(NC(=O)c2nnc(s2)-c2ccccc2)cc1NC(=O)CN1CCOCC1
Show InChI InChI=1S/C22H23N5O4S/c1-30-18-8-7-16(13-17(18)24-19(28)14-27-9-11-31-12-10-27)23-20(29)22-26-25-21(32-22)15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3,(H,23,29)(H,24,28)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300566
PNG
(4-(cyclopropyloxy)-3-({[1-(4-cyclopropylpiperazin-...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)c2ccc(OC3CC3)c(NC(=O)C3(CC3)N3CCN(CC3)C3CC3)c2)cn1
Show InChI InChI=1S/C32H34FN5O3/c33-26-4-2-1-3-25(26)27-11-6-22(20-34-27)35-30(39)21-5-12-29(41-24-9-10-24)28(19-21)36-31(40)32(13-14-32)38-17-15-37(16-18-38)23-7-8-23/h1-6,11-12,19-20,23-24H,7-10,13-18H2,(H,35,39)(H,36,40)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300576
PNG
(N-[5-(3-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-{[...)
Show SMILES COc1cccc(c1)-c1nnc(NC(=O)c2ccc(OC(F)(F)F)c(NC(=O)CN3CCN(C)CC3)c2)s1
Show InChI InChI=1S/C24H25F3N6O4S/c1-32-8-10-33(11-9-32)14-20(34)28-18-13-15(6-7-19(18)37-24(25,26)27)21(35)29-23-31-30-22(38-23)16-4-3-5-17(12-16)36-2/h3-7,12-13H,8-11,14H2,1-2H3,(H,28,34)(H,29,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300601
PNG
(4-(cyclopropyloxy)-3-({[1-(4-methylpiperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1(CC1)C(=O)Nc1cc(ccc1OC1CC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C27H30N6O3S/c1-32-13-15-33(16-14-32)27(11-12-27)25(35)28-21-17-19(7-10-22(21)36-20-8-9-20)23(34)29-26-31-30-24(37-26)18-5-3-2-4-6-18/h2-7,10,17,20H,8-9,11-16H2,1H3,(H,28,35)(H,29,31,34)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300604
PNG
(4-cyano-3-{[(4-methylpiperazin-1-yl)acetyl]amino}-...)
Show SMILES CN1CCN(CC(=O)Nc2cc(ccc2C#N)C(=O)Nc2nnc(s2)-c2ccccc2)CC1
Show InChI InChI=1S/C23H23N7O2S/c1-29-9-11-30(12-10-29)15-20(31)25-19-13-17(7-8-18(19)14-24)21(32)26-23-28-27-22(33-23)16-5-3-2-4-6-16/h2-8,13H,9-12,15H2,1H3,(H,25,31)(H,26,28,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300615
PNG
(6-(3,5-difluorophenyl)-N-[3- ({(2R*)-2-[(1S,4S)-2-...)
Show SMILES CC(N1C[C@@H]2C[C@H]1CO2)C(=O)Nc1cc(NC(=O)c2ccc(nc2)-c2cc(F)cc(F)c2)ccc1OC(F)(F)F
Show InChI InChI=1S/C27H23F5N4O4/c1-14(36-12-21-10-20(36)13-39-21)25(37)35-23-9-19(3-5-24(23)40-27(30,31)32)34-26(38)15-2-4-22(33-11-15)16-6-17(28)8-18(29)7-16/h2-9,11,14,20-21H,10,12-13H2,1H3,(H,34,38)(H,35,37)/t14?,20-,21-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300665
PNG
(4-[(methylsulfonyl)methyl]-3- [(morpholin-4-ylacet...)
Show SMILES CS(=O)(=O)Cc1ccc(cc1NC(=O)CN1CCOCC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C23H25N5O5S2/c1-35(31,32)15-18-8-7-17(13-19(18)24-20(29)14-28-9-11-33-12-10-28)21(30)25-23-27-26-22(34-23)16-5-3-2-4-6-16/h2-8,13H,9-12,14-15H2,1H3,(H,24,29)(H,25,27,30)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300592
PNG
(3-({[(2S)-2,4-dimethylpiperazin-1-yl]acetyl}amino)...)
Show SMILES C[C@H]1CN(C)CCN1CC(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1ccccc1F
Show InChI InChI=1S/C27H27F4N5O3/c1-17-15-35(2)11-12-36(17)16-25(37)34-23-13-18(7-10-24(23)39-27(29,30)31)26(38)33-19-8-9-22(32-14-19)20-5-3-4-6-21(20)28/h3-10,13-14,17H,11-12,15-16H2,1-2H3,(H,33,38)(H,34,37)/t17-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300594
PNG
(3-({[(3R)-3,4-dimethylpiperazin-1-yl]acetyl}amino)...)
Show SMILES C[C@@H]1CN(CC(=O)Nc2cc(ccc2OC(F)(F)F)C(=O)Nc2ccc(nc2)-c2ccccc2F)CCN1C
Show InChI InChI=1S/C27H27F4N5O3/c1-17-15-36(12-11-35(17)2)16-25(37)34-23-13-18(7-10-24(23)39-27(29,30)31)26(38)33-19-8-9-22(32-14-19)20-5-3-4-6-21(20)28/h3-10,13-14,17H,11-12,15-16H2,1-2H3,(H,33,38)(H,34,37)/t17-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300612
PNG
(N-[6-(3-fluorophenyl)pyridin-3- yl]-3-{[2-(morphol...)
Show SMILES CC(N1CCOCC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1cccc(F)c1
Show InChI InChI=1S/C26H24F4N4O4/c1-16(34-9-11-37-12-10-34)24(35)33-22-14-18(5-8-23(22)38-26(28,29)30)25(36)32-20-6-7-21(31-15-20)17-3-2-4-19(27)13-17/h2-8,13-16H,9-12H2,1H3,(H,32,36)(H,33,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300636
PNG
(6-(2-fluorophenyl)-N-[3-{[2- (morpholin-4- yl)prop...)
Show SMILES CC(N1CCOCC1)C(=O)Nc1cc(NC(=O)c2ccc(nc2)-c2ccccc2F)ccc1OC(F)(F)F
Show InChI InChI=1S/C26H24F4N4O4/c1-16(34-10-12-37-13-11-34)24(35)33-22-14-18(7-9-23(22)38-26(28,29)30)32-25(36)17-6-8-21(31-15-17)19-4-2-3-5-20(19)27/h2-9,14-16H,10-13H2,1H3,(H,32,36)(H,33,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300669
PNG
(4-(difluoromethoxy)-3- [(morpholin-4-ylacetyl)amin...)
Show SMILES FC(F)Oc1ccc(cc1NC(=O)CN1CCOCC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C22H21F2N5O4S/c23-21(24)33-17-7-6-15(12-16(17)25-18(30)13-29-8-10-32-11-9-29)19(31)26-22-28-27-20(34-22)14-4-2-1-3-5-14/h1-7,12,21H,8-11,13H2,(H,25,30)(H,26,28,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300671
PNG
(3-{[2-(morpholin-4- yl)propanoyl]amino}-N-(5- phen...)
Show SMILES CC(N1CCOCC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C23H22F3N5O4S/c1-14(31-9-11-34-12-10-31)19(32)27-17-13-16(7-8-18(17)35-23(24,25)26)20(33)28-22-30-29-21(36-22)15-5-3-2-4-6-15/h2-8,13-14H,9-12H2,1H3,(H,27,32)(H,28,30,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300698
PNG
(4-(cyclopropylmethoxy)-3- [(morpholin-4-ylacetyl)a...)
Show SMILES O=C(CN1CCOCC1)Nc1cc(ccc1OCC1CC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C25H27N5O4S/c31-22(15-30-10-12-33-13-11-30)26-20-14-19(8-9-21(20)34-16-17-6-7-17)23(32)27-25-29-28-24(35-25)18-4-2-1-3-5-18/h1-5,8-9,14,17H,6-7,10-13,15-16H2,(H,26,31)(H,27,29,32)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300704
PNG
(3-{[(2R)-2-(4-methylpiperazin-1- yl)butanoyl]amino...)
Show SMILES CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C25H27F3N6O3S/c1-3-19(34-13-11-33(2)12-14-34)22(36)29-18-15-17(9-10-20(18)37-25(26,27)28)21(35)30-24-32-31-23(38-24)16-7-5-4-6-8-16/h4-10,15,19H,3,11-14H2,1-2H3,(H,29,36)(H,30,32,35)/t19-/m1/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300456
PNG
(6-(2,3-difluorophenyl)-N-{3-[(morpholin-4-ylacetyl...)
Show SMILES Fc1cccc(c1F)-c1ccc(cn1)C(=O)Nc1ccc(OC(F)(F)F)c(NC(=O)CN2CCOCC2)c1
Show InChI InChI=1S/C25H21F5N4O4/c26-18-3-1-2-17(23(18)27)19-6-4-15(13-31-19)24(36)32-16-5-7-21(38-25(28,29)30)20(12-16)33-22(35)14-34-8-10-37-11-9-34/h1-7,12-13H,8-11,14H2,(H,32,36)(H,33,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300465
PNG
(N-{4-methoxy-3-[(morpholin-4-ylacetyl)amino]phenyl...)
Show SMILES COc1ccc(cc1)-c1ccc(s1)C(=O)Nc1ccc(OC)c(NC(=O)CN2CCOCC2)c1
Show InChI InChI=1S/C25H27N3O5S/c1-31-19-6-3-17(4-7-19)22-9-10-23(34-22)25(30)26-18-5-8-21(32-2)20(15-18)27-24(29)16-28-11-13-33-14-12-28/h3-10,15H,11-14,16H2,1-2H3,(H,26,30)(H,27,29)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300477
PNG
(4-[(methylsulfonyl)methyl]-3-({[1-(morpholin-4-yl)...)
Show SMILES CS(=O)(=O)Cc1ccc(cc1NC(=O)C1(CC1)N1CCOCC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C25H27N5O5S2/c1-37(33,34)16-19-8-7-18(21(31)27-24-29-28-22(36-24)17-5-3-2-4-6-17)15-20(19)26-23(32)25(9-10-25)30-11-13-35-14-12-30/h2-8,15H,9-14,16H2,1H3,(H,26,32)(H,27,29,31)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300480
PNG
(3-({[1-(morpholin-4-yl)cyclopropyl]carbonyl}amino)...)
Show SMILES FC(F)(F)Oc1ccc(cc1NC(=O)C1(CC1)N1CCOCC1)C(=O)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C24H22F3N5O4S/c25-24(26,27)36-18-7-6-16(19(33)29-22-31-30-20(37-22)15-4-2-1-3-5-15)14-17(18)28-21(34)23(8-9-23)32-10-12-35-13-11-32/h1-7,14H,8-13H2,(H,28,34)(H,29,31,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300511
PNG
(4-methoxy-3-({[1-(morpholin-4-yl)cyclopropyl]carbo...)
Show SMILES COc1ccc(cc1NC(=O)C1(CC1)N1CCOCC1)C(=O)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C27H28N4O4/c1-34-24-10-7-20(17-23(24)30-26(33)27(11-12-27)31-13-15-35-16-14-31)25(32)29-21-8-9-22(28-18-21)19-5-3-2-4-6-19/h2-10,17-18H,11-16H2,1H3,(H,29,32)(H,30,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300543
PNG
(N-[6-(4-acetamidophenyl)pyridin-3-yl]-3-{[2-(morph...)
Show SMILES CC(N1CCOCC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C28H28F3N5O5/c1-17(36-11-13-40-14-12-36)26(38)35-24-15-20(5-10-25(24)41-28(29,30)31)27(39)34-22-8-9-23(32-16-22)19-3-6-21(7-4-19)33-18(2)37/h3-10,15-17H,11-14H2,1-2H3,(H,33,37)(H,34,39)(H,35,38)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300563
PNG
(4-(cyclopropyloxy)-N-[6-(2-fluorophenyl)pyridin-3-...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)c2ccc(OC3CC3)c(NC(=O)CN3CCOCC3)c2)cn1
Show InChI InChI=1S/C27H27FN4O4/c28-22-4-2-1-3-21(22)23-9-6-19(16-29-23)30-27(34)18-5-10-25(36-20-7-8-20)24(15-18)31-26(33)17-32-11-13-35-14-12-32/h1-6,9-10,15-16,20H,7-8,11-14,17H2,(H,30,34)(H,31,33)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300581
PNG
(N-[5-(3-chlorophenyl)-1,3,4-thiadiazol-2-yl]-3-{[(...)
Show SMILES CN1CCN(CC(=O)Nc2cc(ccc2OC(F)(F)F)C(=O)Nc2nnc(s2)-c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C23H22ClF3N6O3S/c1-32-7-9-33(10-8-32)13-19(34)28-17-12-14(5-6-18(17)36-23(25,26)27)20(35)29-22-31-30-21(37-22)15-3-2-4-16(24)11-15/h2-6,11-12H,7-10,13H2,1H3,(H,28,34)(H,29,31,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens)
BDBM300433
PNG
(N-[6-(2-fluorophenyl)pyridin-3-yl]-4-methoxy-3-{[(...)
Show SMILES COc1ccc(cc1NC(=O)CN1C[C@@H]2C[C@H]1CO2)C(=O)Nc1ccc(nc1)-c1ccccc1F
Show InChI InChI=1S/C26H25FN4O4/c1-34-24-9-6-16(10-23(24)30-25(32)14-31-13-19-11-18(31)15-35-19)26(33)29-17-7-8-22(28-12-17)20-4-2-3-5-21(20)27/h2-10,12,18-19H,11,13-15H2,1H3,(H,29,33)(H,30,32)/t18-,19-/m0/s1
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...


US Patent US10130633 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%