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Patent code US10131648

Compile Data Set for Download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300809
PNG
((3S)-3-[4-[[3-(4-Hydroxy-2- methyl- phenyl)benzo[b...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(O)cc4C)c3c2)cc1
Show InChI InChI=1S/C28H24O4S/c1-3-4-21(15-28(30)31)20-6-9-23(10-7-20)32-16-19-5-12-27-25(14-19)26(17-33-27)24-11-8-22(29)13-18(24)2/h5-14,17,21,29H,15-16H2,1-2H3,(H,30,31)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300819
PNG
((3S)-3-(4-((3-(4-((1,1- Dioxidotetrahydro-2H- thio...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5CCS(=O)(=O)CC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C34H34O6S2/c1-3-4-27(19-34(35)36)26-6-8-28(9-7-26)39-21-25-5-12-33-31(18-25)32(22-41-33)30-11-10-29(17-23(30)2)40-20-24-13-15-42(37,38)16-14-24/h5-12,17-18,22,24,27H,13-16,19-21H2,1-2H3,(H,35,36)/t27-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300822
PNG
((3S)-3-(4-((3-(2- Bromophenyl)benzo[b]thiophen- 5-...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4Br)c3c2)cc1
Show InChI InChI=1S/C27H21BrO3S/c1-2-5-20(15-27(29)30)19-9-11-21(12-10-19)31-16-18-8-13-26-23(14-18)24(17-32-26)22-6-3-4-7-25(22)28/h3-4,6-14,17,20H,15-16H2,1H3,(H,29,30)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300824
PNG
((3S)-3-(4-((3-(2-Methylpyridin- 3-yl)benzo[b]thiop...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4cccnc4C)c3c2)cc1
Show InChI InChI=1S/C27H23NO3S/c1-3-5-21(15-27(29)30)20-8-10-22(11-9-20)31-16-19-7-12-26-24(14-19)25(17-32-26)23-6-4-13-28-18(23)2/h4,6-14,17,21H,15-16H2,1-2H3,(H,29,30)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300804
PNG
((3S)-3-[4-[[3-(2- Methylphenyl)benzo[b]thiophen- 5...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H24O3S/c1-3-6-22(16-28(29)30)21-10-12-23(13-11-21)31-17-20-9-14-27-25(15-20)26(18-32-27)24-8-5-4-7-19(24)2/h4-5,7-15,18,22H,16-17H2,1-2H3,(H,29,30)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300835
PNG
(2-(1-(4-((3-(4-((1,1- Dioxidotetrahydro-2H- thiopy...)
Show SMILES Cc1cc(OC2CCS(=O)(=O)CC2)ccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12
Show InChI InChI=1S/C33H32O7S2/c1-21-14-27(40-26-10-12-42(37,38)13-11-26)7-8-28(21)30-20-41-31-9-2-22(15-29(30)31)19-39-25-5-3-23(4-6-25)33(18-32(35)36)16-24(34)17-33/h2-9,14-15,20,26H,10-13,16-19H2,1H3,(H,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300837
PNG
(2-((1r,3r)-3-Hydroxy-1-(4-((3- (4-(2-ethoxyethoxy)...)
Show SMILES CCOCCOc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@@]4(CC(O)=O)C[C@H](O)C4)cc23)c(C)c1
Show InChI InChI=1S/C32H34O6S/c1-3-36-12-13-37-26-9-10-27(21(2)14-26)29-20-39-30-11-4-22(15-28(29)30)19-38-25-7-5-23(6-8-25)32(18-31(34)35)16-24(33)17-32/h4-11,14-15,20,24,33H,3,12-13,16-19H2,1-2H3,(H,34,35)/t24-,32-
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300850
PNG
((3S)-3-(4-((3-(5-(2- Methoxyethoxy)-3- methylpyrid...)
Show SMILES COCCOc1cnc(-c2csc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C30H29NO5S/c1-4-5-23(16-29(32)33)22-7-9-24(10-8-22)36-18-21-6-11-28-26(15-21)27(19-37-28)30-20(2)14-25(17-31-30)35-13-12-34-3/h6-11,14-15,17,19,23H,12-13,16,18H2,1-3H3,(H,32,33)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300852
PNG
((3S)-3-(4-((3-(6-(2- Methoxyethoxy)-2- methylpyrid...)
Show SMILES COCCOc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)cc23)c(C)n1
Show InChI InChI=1S/C30H29NO5S/c1-4-5-23(17-30(32)33)22-7-9-24(10-8-22)36-18-21-6-12-28-26(16-21)27(19-37-28)25-11-13-29(31-20(25)2)35-15-14-34-3/h6-13,16,19,23H,14-15,17-18H2,1-3H3,(H,32,33)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300857
PNG
((3S)-3-[4-[([3-[4-(2,3- Dihydroxypropoxy)-2- methy...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1
Show InChI InChI=1S/C31H30O6S/c1-3-4-23(14-31(34)35)22-7-5-21(6-8-22)17-36-26-10-12-30-28(15-26)29(19-38-30)27-11-9-25(13-20(27)2)37-18-24(33)16-32/h5-13,15,19,23-24,32-33H,14,16-18H2,1-2H3,(H,34,35)/t23-,24?/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300872
PNG
((3S)-3-(6-((3-(4-(3-Hydroxy-3- methylbutoxy)-2- me...)
Show SMILES CC#C[C@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)nc1
Show InChI InChI=1S/C32H33NO5S/c1-5-6-23(17-31(34)35)24-8-12-30(33-18-24)38-19-22-7-11-29-27(16-22)28(20-39-29)26-10-9-25(15-21(26)2)37-14-13-32(3,4)36/h7-12,15-16,18,20,23,36H,13-14,17,19H2,1-4H3,(H,34,35)/t23-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300880
PNG
((3S)-3-(4-((3-(2- Methoxypyridin-3- yl)benzo[b]thi...)
Show SMILES COc1ncccc1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C27H23NO4S/c1-3-5-20(15-26(29)30)19-8-10-21(11-9-19)32-16-18-7-12-25-23(14-18)24(17-33-25)22-6-4-13-28-27(22)31-2/h4,6-14,17,20H,15-16H2,1-2H3,(H,29,30)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300900
PNG
((3R)-3-[4-[[3-(2- Methylphenyl)benzo[b]thiophen- 5...)
Show SMILES CC#C[C@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H24O3S/c1-3-6-22(16-28(29)30)21-10-12-23(13-11-21)31-17-20-9-14-27-25(15-20)26(18-32-27)24-8-5-4-7-19(24)2/h4-5,7-15,18,22H,16-17H2,1-2H3,(H,29,30)/t22-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300816
PNG
((3S)-3-(4-((3-(2-Methyl-4-((3- methyloxetan-3- yl)...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)COC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32O5S/c1-4-5-25(16-32(34)35)24-7-9-26(10-8-24)37-17-23-6-13-31-29(15-23)30(18-39-31)28-12-11-27(14-22(28)2)38-21-33(3)19-36-20-33/h6-15,18,25H,16-17,19-21H2,1-3H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300833
PNG
(2-((1r,3r)-3-Hydroxy-1-(4-((3- (2-methylphenyl) be...)
Show SMILES Cc1ccccc1-c1csc2ccc(COc3ccc(cc3)[C@@]3(CC(O)=O)C[C@H](O)C3)cc12
Show InChI InChI=1S/C28H26O4S/c1-18-4-2-3-5-23(18)25-17-33-26-11-6-19(12-24(25)26)16-32-22-9-7-20(8-10-22)28(15-27(30)31)13-21(29)14-28/h2-12,17,21,29H,13-16H2,1H3,(H,30,31)/t21-,28-
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300849
PNG
(3-(6-((3-(4-(2-Methoxyethoxy)- 2-methylphenyl) ben...)
Show SMILES COCCOc1ccc(-c2csc3ccc(COc4ccc(cn4)C(CC(O)=O)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C30H29NO5S/c1-4-5-22(16-30(32)33)23-7-11-29(31-17-23)36-18-21-6-10-28-26(15-21)27(19-37-28)25-9-8-24(14-20(25)2)35-13-12-34-3/h6-11,14-15,17,19,22H,12-13,16,18H2,1-3H3,(H,32,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300853
PNG
((3S)-3-(4-((3-(6-(2- Methoxyethoxy)-4- methylpyrid...)
Show SMILES COCCOc1cc(C)c(cn1)-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C30H29NO5S/c1-4-5-23(16-30(32)33)22-7-9-24(10-8-22)36-18-21-6-11-28-25(15-21)27(19-37-28)26-17-31-29(14-20(26)2)35-13-12-34-3/h6-11,14-15,17,19,23H,12-13,16,18H2,1-3H3,(H,32,33)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300875
PNG
((3R)-3-(6-((3-(2-Methyl-4- ((tetrahydro-2H-pyran-4...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5CCOCC5)cc4C)c3c2)nc1
Show InChI InChI=1S/C33H33NO5S/c1-3-4-25(17-33(35)36)26-6-10-32(34-18-26)39-20-24-5-9-31-29(16-24)30(21-40-31)28-8-7-27(15-22(28)2)38-19-23-11-13-37-14-12-23/h5-10,15-16,18,21,23,25H,11-14,17,19-20H2,1-2H3,(H,35,36)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300876
PNG
((3S)-3-(6-((3-(4-((1,1- Dioxidotetrahydro-2H- thio...)
Show SMILES CC#C[C@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5CCS(=O)(=O)CC5)cc4C)c3c2)nc1
Show InChI InChI=1S/C33H33NO6S2/c1-3-4-25(17-33(35)36)26-6-10-32(34-18-26)40-20-24-5-9-31-29(16-24)30(21-41-31)28-8-7-27(15-22(28)2)39-19-23-11-13-42(37,38)14-12-23/h5-10,15-16,18,21,23,25H,11-14,17,19-20H2,1-2H3,(H,35,36)/t25-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300878
PNG
((3S)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Show SMILES COCCOc1ccc(-c2csc3ccc(COc4ccc(cn4)[C@@H](CC(O)=O)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C30H29NO5S/c1-4-5-22(16-30(32)33)23-7-11-29(31-17-23)36-18-21-6-10-28-26(15-21)27(19-37-28)25-9-8-24(14-20(25)2)35-13-12-34-3/h6-11,14-15,17,19,22H,12-13,16,18H2,1-3H3,(H,32,33)/t22-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300884
PNG
((3S)-3-(4-((3-(6-Methoxy-4- methylpyridin-3- yl)be...)
Show SMILES COc1cc(C)c(cn1)-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C28H25NO4S/c1-4-5-21(14-28(30)31)20-7-9-22(10-8-20)33-16-19-6-11-26-23(13-19)25(17-34-26)24-15-29-27(32-3)12-18(24)2/h6-13,15,17,21H,14,16H2,1-3H3,(H,30,31)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300891
PNG
((3R)-3-(6-((3-(5-(2- Methoxyethoxy)-3- methylpyrid...)
Show SMILES COCCOc1cnc(-c2csc3ccc(COc4ccc(cn4)[C@H](CC(O)=O)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C29H28N2O5S/c1-4-5-21(14-28(32)33)22-7-9-27(30-15-22)36-17-20-6-8-26-24(13-20)25(18-37-26)29-19(2)12-23(16-31-29)35-11-10-34-3/h6-9,12-13,15-16,18,21H,10-11,14,17H2,1-3H3,(H,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300812
PNG
((3S)-3-[4-[[3-(2,6- Dimethylphenyl)benzo[b]thiophe...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4c(C)cccc4C)c3c2)cc1
Show InChI InChI=1S/C29H26O3S/c1-4-6-23(16-28(30)31)22-10-12-24(13-11-22)32-17-21-9-14-27-25(15-21)26(18-33-27)29-19(2)7-5-8-20(29)3/h5,7-15,18,23H,16-17H2,1-3H3,(H,30,31)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300813
PNG
((3S)-3-(4-((3-(4-(2-(1- Hydroxycyclopropyl)ethoxy)...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCCC5(O)CC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32O5S/c1-3-4-25(19-32(34)35)24-6-8-26(9-7-24)38-20-23-5-12-31-29(18-23)30(21-39-31)28-11-10-27(17-22(28)2)37-16-15-33(36)13-14-33/h5-12,17-18,21,25,36H,13-16,19-20H2,1-2H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300814
PNG
((3S)-3-(4-((3-(4-(3-Hydroxy-3- methylbutoxy)-2- me...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H34O5S/c1-5-6-25(19-32(34)35)24-8-10-26(11-9-24)38-20-23-7-14-31-29(18-23)30(21-39-31)28-13-12-27(17-22(28)2)37-16-15-33(3,4)36/h7-14,17-18,21,25,36H,15-16,19-20H2,1-4H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300815
PNG
((3S)-3-(4-((3-(4-(2,3- Dihydroxypropoxy)-2- methyl...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1
Show InChI InChI=1S/C31H30O6S/c1-3-4-23(15-31(34)35)22-6-8-25(9-7-22)36-17-21-5-12-30-28(14-21)29(19-38-30)27-11-10-26(13-20(27)2)37-18-24(33)16-32/h5-14,19,23-24,32-33H,15-18H2,1-2H3,(H,34,35)/t23-,24?/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300817
PNG
((3S)-3-(4-((3-(2-Methyl-4- ((tetrahydro-2H-pyran-4...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OC5CCOCC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32O5S/c1-3-4-25(19-33(34)35)24-6-8-26(9-7-24)37-20-23-5-12-32-30(18-23)31(21-39-32)29-11-10-28(17-22(29)2)38-27-13-15-36-16-14-27/h5-12,17-18,21,25,27H,13-16,19-20H2,1-2H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300818
PNG
((3S)-3-(4-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Show SMILES COCCOc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C31H30O5S/c1-4-5-24(18-31(32)33)23-7-9-25(10-8-23)36-19-22-6-13-30-28(17-22)29(20-37-30)27-12-11-26(16-21(27)2)35-15-14-34-3/h6-13,16-17,20,24H,14-15,18-19H2,1-3H3,(H,32,33)/t24-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300821
PNG
((3S)-3-(4-((3-(2- Chlorophenyl)benzo[b]thiophen- 5...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4Cl)c3c2)cc1
Show InChI InChI=1S/C27H21ClO3S/c1-2-5-20(15-27(29)30)19-9-11-21(12-10-19)31-16-18-8-13-26-23(14-18)24(17-32-26)22-6-3-4-7-25(22)28/h3-4,6-14,17,20H,15-16H2,1H3,(H,29,30)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300830
PNG
(2-(1-(4-((3-(4-(1,1-Dioxido-3,6- dihydro-2H-thiopy...)
Show SMILES Cc1cc(ccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12)C1=CCS(=O)(=O)CC1
Show InChI InChI=1S/C33H30O6S2/c1-21-14-24(23-10-12-41(37,38)13-11-23)3-8-28(21)30-20-40-31-9-2-22(15-29(30)31)19-39-27-6-4-25(5-7-27)33(18-32(35)36)16-26(34)17-33/h2-10,14-15,20H,11-13,16-19H2,1H3,(H,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300832
PNG
(2-(3-Oxo-1-(4-((3-(2- methylphenyl) benzo[b]thioph...)
Show SMILES Cc1ccccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12
Show InChI InChI=1S/C28H24O4S/c1-18-4-2-3-5-23(18)25-17-33-26-11-6-19(12-24(25)26)16-32-22-9-7-20(8-10-22)28(15-27(30)31)13-21(29)14-28/h2-12,17H,13-16H2,1H3,(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300846
PNG
((3S)-3-(4-((3-(2-Methyl-6- (methylsulfonamido)phen...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4c(C)cccc4NS(C)(=O)=O)c3c2)cc1
Show InChI InChI=1S/C29H27NO5S2/c1-4-6-22(16-28(31)32)21-10-12-23(13-11-21)35-17-20-9-14-27-24(15-20)25(18-36-27)29-19(2)7-5-8-26(29)30-37(3,33)34/h5,7-15,18,22,30H,16-17H2,1-3H3,(H,31,32)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300862
PNG
((3S)-3-(4-(((3-(2-Methyl-4-((3- methyl-1,1-dioxido...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32O6S2/c1-4-5-25(15-32(34)35)24-8-6-23(7-9-24)17-38-27-11-13-31-29(16-27)30(18-40-31)28-12-10-26(14-22(28)2)39-19-33(3)20-41(36,37)21-33/h6-14,16,18,25H,15,17,19-21H2,1-3H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300874
PNG
((3S)-3-(6-((3-(2-Methyl-4- ((tetrahydro-2H-pyran-4...)
Show SMILES CC#C[C@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5CCOCC5)cc4C)c3c2)nc1
Show InChI InChI=1S/C33H33NO5S/c1-3-4-25(17-33(35)36)26-6-10-32(34-18-26)39-20-24-5-9-31-29(16-24)30(21-40-31)28-8-7-27(15-22(28)2)38-19-23-11-13-37-14-12-23/h5-10,15-16,18,21,23,25H,11-14,17,19-20H2,1-2H3,(H,35,36)/t25-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300893
PNG
((3S)-3-(4-((3-(3- Methoxypyridin-2- yl)benzo[b]thi...)
Show SMILES COc1cccnc1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C27H23NO4S/c1-3-5-20(15-26(29)30)19-8-10-21(11-9-19)32-16-18-7-12-25-22(14-18)23(17-33-25)27-24(31-2)6-4-13-28-27/h4,6-14,17,20H,15-16H2,1-2H3,(H,29,30)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300898
PNG
((3S)-3-(4-((3-(2-Methyl-4- (piperidin-4- yl)phenyl...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)C4CCNCC4)c3c2)cc1
Show InChI InChI=1S/C33H33NO3S/c1-3-4-26(19-33(35)36)24-6-9-28(10-7-24)37-20-23-5-12-32-30(18-23)31(21-38-32)29-11-8-27(17-22(29)2)25-13-15-34-16-14-25/h5-12,17-18,21,25-26,34H,13-16,19-20H2,1-2H3,(H,35,36)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300899
PNG
(3-(4-((3-(2- Methylphenyl)benzo[b]thiophen- 5-yl)m...)
Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H24O3S/c1-3-6-22(16-28(29)30)21-10-12-23(13-11-21)31-17-20-9-14-27-25(15-20)26(18-32-27)24-8-5-4-7-19(24)2/h4-5,7-15,18,22H,16-17H2,1-2H3,(H,29,30)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300810
PNG
((3S)-3-[4-[[3-[4-(1,1- Dioxothian-4-yl)-2-methyl- ...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)C4CCS(=O)(=O)CC4)c3c2)cc1
Show InChI InChI=1S/C33H32O5S2/c1-3-4-26(19-33(34)35)24-6-9-28(10-7-24)38-20-23-5-12-32-30(18-23)31(21-39-32)29-11-8-27(17-22(29)2)25-13-15-40(36,37)16-14-25/h5-12,17-18,21,25-26H,13-16,19-20H2,1-2H3,(H,34,35)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300820
PNG
((3S)-3-(4-((3-(2-Methyl-4-((3- methyl-1,1-dioxidot...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32O6S2/c1-4-5-25(16-32(34)35)24-7-9-26(10-8-24)38-17-23-6-13-31-29(15-23)30(18-40-31)28-12-11-27(14-22(28)2)39-19-33(3)20-41(36,37)21-33/h6-15,18,25H,16-17,19-21H2,1-3H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300826
PNG
((3S)-3-(4-(((3-(2-Methyl-4-(3- (methylsulfonyl)pro...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1
Show InChI InChI=1S/C32H32O6S2/c1-4-6-25(18-32(33)34)24-9-7-23(8-10-24)20-38-27-12-14-31-29(19-27)30(21-39-31)28-13-11-26(17-22(28)2)37-15-5-16-40(3,35)36/h7-14,17,19,21,25H,5,15-16,18,20H2,1-3H3,(H,33,34)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300840
PNG
(2-(1-(4-((3-(2-Methylpyridin-3- yl)benzo[b]thiophe...)
Show SMILES Cc1ncccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12
Show InChI InChI=1S/C27H23NO4S/c1-17-22(3-2-10-28-17)24-16-33-25-9-4-18(11-23(24)25)15-32-21-7-5-19(6-8-21)27(14-26(30)31)12-20(29)13-27/h2-11,16H,12-15H2,1H3,(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300842
PNG
(2-(1-(4-((3-(4-(1,1-Dioxido-1- thia-6-azaspiro[3.3...)
Show SMILES Cc1cc(ccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12)N1CC2(CCS2(=O)=O)C1
Show InChI InChI=1S/C33H31NO6S2/c1-21-12-24(34-19-33(20-34)10-11-42(33,38)39)5-8-27(21)29-18-41-30-9-2-22(13-28(29)30)17-40-26-6-3-23(4-7-26)32(16-31(36)37)14-25(35)15-32/h2-9,12-13,18H,10-11,14-17,19-20H2,1H3,(H,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300848
PNG
(3-(6-((3-(2-Methyl-4- ((tetrahydro-2H-pyran-4- yl)...)
Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OC5CCOCC5)cc4C)c3c2)nc1
Show InChI InChI=1S/C32H31NO5S/c1-3-4-23(17-32(34)35)24-6-10-31(33-18-24)37-19-22-5-9-30-28(16-22)29(20-39-30)27-8-7-26(15-21(27)2)38-25-11-13-36-14-12-25/h5-10,15-16,18,20,23,25H,11-14,17,19H2,1-2H3,(H,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300859
PNG
((3S)-3-[4-[([3-[2-Methyl-4- (oxan-4-yloxy)phenyl]-...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OC5CCOCC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32O5S/c1-3-4-25(18-33(34)35)24-7-5-23(6-8-24)20-37-27-10-12-32-30(19-27)31(21-39-32)29-11-9-28(17-22(29)2)38-26-13-15-36-16-14-26/h5-12,17,19,21,25-26H,13-16,18,20H2,1-2H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300870
PNG
((3S)-3-[4-([3-[2-(2- Methoxyethoxy)phenyl]-1- benz...)
Show SMILES COCCOc1ccccc1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C30H28O5S/c1-3-6-23(18-30(31)32)22-10-12-24(13-11-22)35-19-21-9-14-29-26(17-21)27(20-36-29)25-7-4-5-8-28(25)34-16-15-33-2/h4-5,7-14,17,20,23H,15-16,18-19H2,1-2H3,(H,31,32)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300877
PNG
((3R)-3-(6-((3-(4-((1,1- Dioxidotetrahydro-2H- thio...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5CCS(=O)(=O)CC5)cc4C)c3c2)nc1
Show InChI InChI=1S/C33H33NO6S2/c1-3-4-25(17-33(35)36)26-6-10-32(34-18-26)40-20-24-5-9-31-29(16-24)30(21-41-31)28-8-7-27(15-22(28)2)39-19-23-11-13-42(37,38)14-12-23/h5-10,15-16,18,21,23,25H,11-14,17,19-20H2,1-2H3,(H,35,36)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300805
PNG
((3S)-3-[4-[[3-[4-[(4-Hydroxy- 1,1-dioxo-thian-4-yl...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(O)CCS(=O)(=O)CC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C34H34O7S2/c1-3-4-26(19-33(35)36)25-6-8-27(9-7-25)40-20-24-5-12-32-30(18-24)31(21-42-32)29-11-10-28(17-23(29)2)41-22-34(37)13-15-43(38,39)16-14-34/h5-12,17-18,21,26,37H,13-16,19-20,22H2,1-2H3,(H,35,36)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300807
PNG
((3S)-3-[4-[[3-[4-(1,1-Dioxo-1,4- thiazinane-4-carb...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)C(=O)N4CCS(=O)(=O)CC4)c3c2)cc1
Show InChI InChI=1S/C33H31NO6S2/c1-3-4-25(19-32(35)36)24-6-9-27(10-7-24)40-20-23-5-12-31-29(18-23)30(21-41-31)28-11-8-26(17-22(28)2)33(37)34-13-15-42(38,39)16-14-34/h5-12,17-18,21,25H,13-16,19-20H2,1-2H3,(H,35,36)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300808
PNG
((3S)-3-[4-[[3-[4-(1,1-Dioxo-3,6- dihydro-2H-thiopy...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)C4=CCS(=O)(=O)CC4)c3c2)cc1
Show InChI InChI=1S/C33H30O5S2/c1-3-4-26(19-33(34)35)24-6-9-28(10-7-24)38-20-23-5-12-32-30(18-23)31(21-39-32)29-11-8-27(17-22(29)2)25-13-15-40(36,37)16-14-25/h5-13,17-18,21,26H,14-16,19-20H2,1-2H3,(H,34,35)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300828
PNG
((3S)-3-(4-(((3-(4-(1,1- Dioxidotetrahydro-2H- thio...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(cc4C)C4CCS(=O)(=O)CC4)c3c2)cc1
Show InChI InChI=1S/C33H32O5S2/c1-3-4-26(18-33(34)35)24-7-5-23(6-8-24)20-38-28-10-12-32-30(19-28)31(21-39-32)29-11-9-27(17-22(29)2)25-13-15-40(36,37)16-14-25/h5-12,17,19,21,25-26H,13-16,18,20H2,1-2H3,(H,34,35)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300829
PNG
((3S)-3-(4-(((3-(2,6- Dimethylphenyl)benzo[b]thioph...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4c(C)cccc4C)c3c2)cc1
Show InChI InChI=1S/C29H26O3S/c1-4-6-23(15-28(30)31)22-11-9-21(10-12-22)17-32-24-13-14-27-25(16-24)26(18-33-27)29-19(2)7-5-8-20(29)3/h5,7-14,16,18,23H,15,17H2,1-3H3,(H,30,31)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300834
PNG
(2-(1-(4-((3-(4-(2- Ethoxyethoxy)-2- methylphenyl)b...)
Show SMILES CCOCCOc1ccc(-c2csc3ccc(COc4ccc(cc4)C4(CC(O)=O)CC(=O)C4)cc23)c(C)c1
Show InChI InChI=1S/C32H32O6S/c1-3-36-12-13-37-26-9-10-27(21(2)14-26)29-20-39-30-11-4-22(15-28(29)30)19-38-25-7-5-23(6-8-25)32(18-31(34)35)16-24(33)17-32/h4-11,14-15,20H,3,12-13,16-19H2,1-2H3,(H,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300838
PNG
(2-((1r,3r)-1-(4-((3-(4-((1,1- Dioxidotetrahydro-2H...)
Show SMILES Cc1cc(OC2CCS(=O)(=O)CC2)ccc1-c1csc2ccc(COc3ccc(cc3)[C@@]3(CC(O)=O)C[C@H](O)C3)cc12
Show InChI InChI=1S/C33H34O7S2/c1-21-14-27(40-26-10-12-42(37,38)13-11-26)7-8-28(21)30-20-41-31-9-2-22(15-29(30)31)19-39-25-5-3-23(4-6-25)33(18-32(35)36)16-24(34)17-33/h2-9,14-15,20,24,26,34H,10-13,16-19H2,1H3,(H,35,36)/t24-,33-
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300839
PNG
(2-((1r,3r)-3-Hydroxy-1-(4-((3- (2-methyl-4-((tetra...)
Show SMILES Cc1cc(OC2CCOCC2)ccc1-c1csc2ccc(COc3ccc(cc3)[C@@]3(CC(O)=O)C[C@H](O)C3)cc12
Show InChI InChI=1S/C33H34O6S/c1-21-14-27(39-26-10-12-37-13-11-26)7-8-28(21)30-20-40-31-9-2-22(15-29(30)31)19-38-25-5-3-23(4-6-25)33(18-32(35)36)16-24(34)17-33/h2-9,14-15,20,24,26,34H,10-13,16-19H2,1H3,(H,35,36)/t24-,33-
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300841
PNG
(2-((1r,3r)-3-Hydroxy-1-(4-((3- (2-methylpyridin-3-...)
Show SMILES Cc1ncccc1-c1csc2ccc(COc3ccc(cc3)[C@@]3(CC(O)=O)C[C@H](O)C3)cc12
Show InChI InChI=1S/C27H25NO4S/c1-17-22(3-2-10-28-17)24-16-33-25-9-4-18(11-23(24)25)15-32-21-7-5-19(6-8-21)27(14-26(30)31)12-20(29)13-27/h2-11,16,20,29H,12-15H2,1H3,(H,30,31)/t20-,27-
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300843
PNG
((3S)-3-(4-((3-(2-Methyl-5- (methylsulfonyl)phenyl)...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4cc(ccc4C)S(C)(=O)=O)c3c2)cc1
Show InChI InChI=1S/C29H26O5S2/c1-4-5-22(15-29(30)31)21-8-10-23(11-9-21)34-17-20-7-13-28-26(14-20)27(18-35-28)25-16-24(36(3,32)33)12-6-19(25)2/h6-14,16,18,22H,15,17H2,1-3H3,(H,30,31)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300847
PNG
(3-(6-((3-(2- Methylphenyl)benzo[b]thiophen- 5-yl)m...)
Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)nc1
Show InChI InChI=1S/C27H23NO3S/c1-3-6-20(14-27(29)30)21-10-12-26(28-15-21)31-16-19-9-11-25-23(13-19)24(17-32-25)22-8-5-4-7-18(22)2/h4-5,7-13,15,17,20H,14,16H2,1-2H3,(H,29,30)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300856
PNG
((3S)-3-[4-[([3-[4-(3-Hydroxy-3- methylbutoxy)-2- m...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H34O5S/c1-5-6-25(18-32(34)35)24-9-7-23(8-10-24)20-38-27-12-14-31-29(19-27)30(21-39-31)28-13-11-26(17-22(28)2)37-16-15-33(3,4)36/h7-14,17,19,21,25,36H,15-16,18,20H2,1-4H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300861
PNG
((3S)-3-{4-[((3-{4-[(1,1-Dioxo- tetrahydro-2H-thiop...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OCC5CCS(=O)(=O)CC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C34H34O6S2/c1-3-4-27(18-34(35)36)26-7-5-24(6-8-26)20-40-29-10-12-33-31(19-29)32(22-41-33)30-11-9-28(17-23(30)2)39-21-25-13-15-42(37,38)16-14-25/h5-12,17,19,22,25,27H,13-16,18,20-21H2,1-2H3,(H,35,36)/t27-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300863
PNG
(3-[6-([3-[4-(3-Hydroxy-3- methylbutoxy)-2- methylp...)
Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)nc1
Show InChI InChI=1S/C32H33NO5S/c1-5-6-23(17-31(34)35)24-8-12-30(33-18-24)38-19-22-7-11-29-27(16-22)28(20-39-29)26-10-9-25(15-21(26)2)37-14-13-32(3,4)36/h7-12,15-16,18,20,23,36H,13-14,17,19H2,1-4H3,(H,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300871
PNG
((3S)-3-[4-[[3-(2- Methanesulfonylphenyl)-1- benzot...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4S(C)(=O)=O)c3c2)cc1
Show InChI InChI=1S/C28H24O5S2/c1-3-6-21(16-28(29)30)20-10-12-22(13-11-20)33-17-19-9-14-26-24(15-19)25(18-34-26)23-7-4-5-8-27(23)35(2,31)32/h4-5,7-15,18,21H,16-17H2,1-2H3,(H,29,30)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300882
PNG
((3S)-3-(4-((3-(6-Methoxy-2- methylpyridin-3- yl)be...)
Show SMILES COc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)cc23)c(C)n1
Show InChI InChI=1S/C28H25NO4S/c1-4-5-21(15-28(30)31)20-7-9-22(10-8-20)33-16-19-6-12-26-24(14-19)25(17-34-26)23-11-13-27(32-3)29-18(23)2/h6-14,17,21H,15-16H2,1-3H3,(H,30,31)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300886
PNG
((3S)-3-(4-((3-(5-Methoxy-3- methylpyridin-2- yl)be...)
Show SMILES COc1cnc(-c2csc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C28H25NO4S/c1-4-5-21(14-27(30)31)20-7-9-22(10-8-20)33-16-19-6-11-26-24(13-19)25(17-34-26)28-18(2)12-23(32-3)15-29-28/h6-13,15,17,21H,14,16H2,1-3H3,(H,30,31)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300889
PNG
((3R)-3-(6-((3-(5-(2- Methoxyethoxy)-2- methylpheny...)
Show SMILES COCCOc1ccc(C)c(c1)-c1csc2ccc(COc3ccc(cn3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C30H29NO5S/c1-4-5-22(15-30(32)33)23-8-11-29(31-17-23)36-18-21-7-10-28-26(14-21)27(19-37-28)25-16-24(9-6-20(25)2)35-13-12-34-3/h6-11,14,16-17,19,22H,12-13,15,18H2,1-3H3,(H,32,33)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300896
PNG
((3S)-3-(4-((3-(6-Methoxy-3- methylpyridin-2- yl)be...)
Show SMILES COc1ccc(C)c(n1)-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C28H25NO4S/c1-4-5-21(15-27(30)31)20-8-10-22(11-9-20)33-16-19-7-12-25-23(14-19)24(17-34-25)28-18(2)6-13-26(29-28)32-3/h6-14,17,21H,15-16H2,1-3H3,(H,30,31)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300804
PNG
((3S)-3-[4-[[3-(2- Methylphenyl)benzo[b]thiophen- 5...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1
Show InChI InChI=1S/C28H24O3S/c1-3-6-22(16-28(29)30)21-10-12-23(13-11-21)31-17-20-9-14-27-25(15-20)26(18-32-27)24-8-5-4-7-19(24)2/h4-5,7-15,18,22H,16-17H2,1-2H3,(H,29,30)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300823
PNG
((3S)-3-(4-((3-(2- (Trifluoromethyl)phenyl)benzo [b...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4C(F)(F)F)c3c2)cc1
Show InChI InChI=1S/C28H21F3O3S/c1-2-5-20(15-27(32)33)19-9-11-21(12-10-19)34-16-18-8-13-26-23(14-18)24(17-35-26)22-6-3-4-7-25(22)28(29,30)31/h3-4,6-14,17,20H,15-16H2,1H3,(H,32,33)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300866
PNG
(3-(6-((3-(2-Methyl-4-((3- methyl-1,1-dioxidothieta...)
Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)nc1
Show InChI InChI=1S/C32H31NO6S2/c1-4-5-23(14-31(34)35)24-7-11-30(33-15-24)38-16-22-6-10-29-27(13-22)28(17-40-29)26-9-8-25(12-21(26)2)39-18-32(3)19-41(36,37)20-32/h6-13,15,17,23H,14,16,18-20H2,1-3H3,(H,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300873
PNG
((3R)-3-(6-((3-(4-(3-Hydroxy-3- methylbutoxy)-2- me...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)nc1
Show InChI InChI=1S/C32H33NO5S/c1-5-6-23(17-31(34)35)24-8-12-30(33-18-24)38-19-22-7-11-29-27(16-22)28(20-39-29)26-10-9-25(15-21(26)2)37-14-13-32(3,4)36/h7-12,15-16,18,20,23,36H,13-14,17,19H2,1-4H3,(H,34,35)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300881
PNG
((3S)-3-(4-((3-(2- Methoxyphenyl)benzo[b]thiophen- ...)
Show SMILES COc1ccccc1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C28H24O4S/c1-3-6-21(16-28(29)30)20-10-12-22(13-11-20)32-17-19-9-14-27-24(15-19)25(18-33-27)23-7-4-5-8-26(23)31-2/h4-5,7-15,18,21H,16-17H2,1-2H3,(H,29,30)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300883
PNG
((3S)-3-(4-((3-(4- Methoxypyridin-3- yl)benzo[b]thi...)
Show SMILES COc1ccncc1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C27H23NO4S/c1-3-4-20(14-27(29)30)19-6-8-21(9-7-19)32-16-18-5-10-26-22(13-18)24(17-33-26)23-15-28-12-11-25(23)31-2/h5-13,15,17,20H,14,16H2,1-2H3,(H,29,30)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300890
PNG
((3R)-3-(6-((3-(3-(2- Methoxyethoxy)-2- methylpheny...)
Show SMILES COCCOc1cccc(-c2csc3ccc(COc4ccc(cn4)[C@H](CC(O)=O)C#CC)cc23)c1C
Show InChI InChI=1S/C30H29NO5S/c1-4-6-22(16-30(32)33)23-10-12-29(31-17-23)36-18-21-9-11-28-25(15-21)26(19-37-28)24-7-5-8-27(20(24)2)35-14-13-34-3/h5,7-12,15,17,19,22H,13-14,16,18H2,1-3H3,(H,32,33)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300892
PNG
((3R)-3-(6-((3-(2-Chloro-5- methylpyridin-4- yl)ben...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4cc(Cl)ncc4C)c3c2)nc1
Show InChI InChI=1S/C26H21ClN2O3S/c1-3-4-18(10-26(30)31)19-6-8-25(29-13-19)32-14-17-5-7-23-21(9-17)22(15-33-23)20-11-24(27)28-12-16(20)2/h5-9,11-13,15,18H,10,14H2,1-2H3,(H,30,31)/t18-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300897
PNG
((3S)-3-(4-((3-(2-Methyl-4- (piperidin-4- ylmethyl)...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(CC5CCNCC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C34H35NO3S/c1-3-4-28(20-34(36)37)27-7-9-29(10-8-27)38-21-26-6-12-33-31(19-26)32(22-39-33)30-11-5-25(17-23(30)2)18-24-13-15-35-16-14-24/h5-12,17,19,22,24,28,35H,13-16,18,20-21H2,1-2H3,(H,36,37)/t28-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300803
PNG
(3-[4-[[3-(2- Methylphenyl)benzo[b]thiophen- 5-yl]m...)
Show SMILES Cc1ccccc1-c1csc2ccc(COc3ccc(CCC(O)=O)cc3)cc12
Show InChI InChI=1S/C25H22O3S/c1-17-4-2-3-5-21(17)23-16-29-24-12-8-19(14-22(23)24)15-28-20-10-6-18(7-11-20)9-13-25(26)27/h2-8,10-12,14,16H,9,13,15H2,1H3,(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300811
PNG
((3S)-3-[4-[[3-[4-(1,1- Dioxothian-4-yl)oxy-2-methy...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3sc(C)c(-c4ccc(OC5CCS(=O)(=O)CC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C34H34O6S2/c1-4-5-26(20-33(35)36)25-7-9-27(10-8-25)39-21-24-6-13-32-31(19-24)34(23(3)41-32)30-12-11-29(18-22(30)2)40-28-14-16-42(37,38)17-15-28/h6-13,18-19,26,28H,14-17,20-21H2,1-3H3,(H,35,36)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300831
PNG
(2-(1-(4-((3-(4-(1,1- Dioxidotetrahydro-2H- thiopyr...)
Show SMILES Cc1cc(ccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C33H32O6S2/c1-21-14-24(23-10-12-41(37,38)13-11-23)3-8-28(21)30-20-40-31-9-2-22(15-29(30)31)19-39-27-6-4-25(5-7-27)33(18-32(35)36)16-26(34)17-33/h2-9,14-15,20,23H,10-13,16-19H2,1H3,(H,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300854
PNG
((3S)-3-(4-((3-(2-Chloro-5- methylpyridin-4- yl)ben...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4cc(Cl)ncc4C)c3c2)cc1
Show InChI InChI=1S/C27H22ClNO3S/c1-3-4-20(12-27(30)31)19-6-8-21(9-7-19)32-15-18-5-10-25-23(11-18)24(16-33-25)22-13-26(28)29-14-17(22)2/h5-11,13-14,16,20H,12,15H2,1-2H3,(H,30,31)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300858
PNG
((3S)-3-(4-[[(3-[2-Methyl-4-[(3- methyloxetan-3- yl...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OCC5(C)COC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C33H32O5S/c1-4-5-25(15-32(34)35)24-8-6-23(7-9-24)17-37-27-11-13-31-29(16-27)30(18-39-31)28-12-10-26(14-22(28)2)38-21-33(3)19-36-20-33/h6-14,16,18,25H,15,17,19-21H2,1-3H3,(H,34,35)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300864
PNG
(3-(6-((3-(4-(2,3- Dihydroxypropoxy)-2- phenyl)benz...)
Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)nc1
Show InChI InChI=1S/C30H29NO6S/c1-3-4-21(13-30(34)35)22-6-10-29(31-14-22)37-16-20-5-9-28-26(12-20)27(18-38-28)25-8-7-24(11-19(25)2)36-17-23(33)15-32/h5-12,14,18,21,23,32-33H,13,15-17H2,1-2H3,(H,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300867
PNG
((3S)-3-[4-([3-[5-(2- Methoxyethoxy)-2- methylpheny...)
Show SMILES COCCOc1ccc(C)c(c1)-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C31H30O5S/c1-4-5-24(17-31(32)33)23-8-11-25(12-9-23)36-19-22-7-13-30-28(16-22)29(20-37-30)27-18-26(10-6-21(27)2)35-15-14-34-3/h6-13,16,18,20,24H,14-15,17,19H2,1-3H3,(H,32,33)/t24-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300868
PNG
((3S)-3-[4-([3-[2-(2- Methoxyethoxy)-6- methylpheny...)
Show SMILES COCCOc1cccc(C)c1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C31H30O5S/c1-4-6-24(18-30(32)33)23-10-12-25(13-11-23)36-19-22-9-14-29-26(17-22)27(20-37-29)31-21(2)7-5-8-28(31)35-16-15-34-3/h5,7-14,17,20,24H,15-16,18-19H2,1-3H3,(H,32,33)/t24-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300869
PNG
((3S)-3-[4-([3-[3-(2- Methoxyethoxy)-2- methylpheny...)
Show SMILES COCCOc1cccc(-c2csc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)cc23)c1C
Show InChI InChI=1S/C31H30O5S/c1-4-6-24(18-31(32)33)23-10-12-25(13-11-23)36-19-22-9-14-30-27(17-22)28(20-37-30)26-7-5-8-29(21(26)2)35-16-15-34-3/h5,7-14,17,20,24H,15-16,18-19H2,1-3H3,(H,32,33)/t24-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300879
PNG
((3R)-3-(6-((3-(4-(2- Methoxyethoxy)-2- methylpheny...)
Show SMILES COCCOc1ccc(-c2csc3ccc(COc4ccc(cn4)[C@H](CC(O)=O)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C30H29NO5S/c1-4-5-22(16-30(32)33)23-7-11-29(31-17-23)36-18-21-6-10-28-26(15-21)27(19-37-28)25-9-8-24(14-20(25)2)35-13-12-34-3/h6-11,14-15,17,19,22H,12-13,16,18H2,1-3H3,(H,32,33)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300885
PNG
((3S)-3-(4-((3-(3- Methoxypyridin-4- yl)benzo[b]thi...)
Show SMILES COc1cnccc1-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C27H23NO4S/c1-3-4-20(14-27(29)30)19-6-8-21(9-7-19)32-16-18-5-10-26-23(13-18)24(17-33-26)22-11-12-28-15-25(22)31-2/h5-13,15,17,20H,14,16H2,1-2H3,(H,29,30)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300887
PNG
((3R)-3-[6-[[3-(2- Methylphenyl)benzo[b]thiophen- 5...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)nc1
Show InChI InChI=1S/C27H23NO3S/c1-3-6-20(14-27(29)30)21-10-12-26(28-15-21)31-16-19-9-11-25-23(13-19)24(17-32-25)22-8-5-4-7-18(22)2/h4-5,7-13,15,17,20H,14,16H2,1-2H3,(H,29,30)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300806
PNG
((3S)-3-[4-[[3-[2-Methyl-4-(3- methylsulfonylpropox...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1
Show InChI InChI=1S/C32H32O6S2/c1-4-6-25(19-32(33)34)24-8-10-26(11-9-24)38-20-23-7-14-31-29(18-23)30(21-39-31)28-13-12-27(17-22(28)2)37-15-5-16-40(3,35)36/h7-14,17-18,21,25H,5,15-16,19-20H2,1-3H3,(H,33,34)/t25-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300827
PNG
((3S)-3-(4-(((3-(4-(1,1-Dioxido- 3,6-dihydro-2H-thi...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(cc4C)C4=CCS(=O)(=O)CC4)c3c2)cc1
Show InChI InChI=1S/C33H30O5S2/c1-3-4-26(18-33(34)35)24-7-5-23(6-8-24)20-38-28-10-12-32-30(19-28)31(21-39-32)29-11-9-27(17-22(29)2)25-13-15-40(36,37)16-14-25/h5-13,17,19,21,26H,14-16,18,20H2,1-2H3,(H,34,35)/t26-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300836
PNG
(2-(1-(4-((3-(2-Methyl-4- ((tetrahydro-2H-pyran-4- ...)
Show SMILES Cc1cc(OC2CCOCC2)ccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12
Show InChI InChI=1S/C33H32O6S/c1-21-14-27(39-26-10-12-37-13-11-26)7-8-28(21)30-20-40-31-9-2-22(15-29(30)31)19-38-25-5-3-23(4-6-25)33(18-32(35)36)16-24(34)17-33/h2-9,14-15,20,26H,10-13,16-19H2,1H3,(H,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300844
PNG
((3S)-3-(4-((3-(2-Methyl-4- (methylsulfonyl)phenyl)...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)S(C)(=O)=O)c3c2)cc1
Show InChI InChI=1S/C29H26O5S2/c1-4-5-22(16-29(30)31)21-7-9-23(10-8-21)34-17-20-6-13-28-26(15-20)27(18-35-28)25-12-11-24(14-19(25)2)36(3,32)33/h6-15,18,22H,16-17H2,1-3H3,(H,30,31)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300845
PNG
((3S)-3-(4-((3-(2-Methyl-5- (methylsulfonamido)phen...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4cc(NS(C)(=O)=O)ccc4C)c3c2)cc1
Show InChI InChI=1S/C29H27NO5S2/c1-4-5-22(15-29(31)32)21-8-11-24(12-9-21)35-17-20-7-13-28-26(14-20)27(18-36-28)25-16-23(10-6-19(25)2)30-37(3,33)34/h6-14,16,18,22,30H,15,17H2,1-3H3,(H,31,32)/t22-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300851
PNG
((3S)-3-(4-((3-(5-(2- Methoxyethoxy)-2- methylpyrid...)
Show SMILES COCCOc1cnc(C)c(c1)-c1csc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C30H29NO5S/c1-4-5-23(15-30(32)33)22-7-9-24(10-8-22)36-18-21-6-11-29-27(14-21)28(19-37-29)26-16-25(17-31-20(26)2)35-13-12-34-3/h6-11,14,16-17,19,23H,12-13,15,18H2,1-3H3,(H,32,33)/t23-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300855
PNG
(3-(4-(((3-(2- Methylphenyl)benzo[b]thiophen- 5-yl)...)
Show SMILES Cc1ccccc1-c1csc2ccc(OCc3ccc(CCC(O)=O)cc3)cc12
Show InChI InChI=1S/C25H22O3S/c1-17-4-2-3-5-21(17)23-16-29-24-12-11-20(14-22(23)24)28-15-19-8-6-18(7-9-19)10-13-25(26)27/h2-9,11-12,14,16H,10,13,15H2,1H3,(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300860
PNG
((3S)-3-[4-[([3-[4-(2- Methoxyethoxy)-2- methylphen...)
Show SMILES COCCOc1ccc(-c2csc3ccc(OCc4ccc(cc4)[C@H](CC(O)=O)C#CC)cc23)c(C)c1
Show InChI InChI=1S/C31H30O5S/c1-4-5-24(17-31(32)33)23-8-6-22(7-9-23)19-36-26-11-13-30-28(18-26)29(20-37-30)27-12-10-25(16-21(27)2)35-15-14-34-3/h6-13,16,18,20,24H,14-15,17,19H2,1-3H3,(H,32,33)/t24-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300865
PNG
(3-(6-((3-(4-((1,1- Dioxidotetrahydro-2H- thiopyran...)
Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5CCS(=O)(=O)CC5)cc4C)c3c2)nc1
Show InChI InChI=1S/C33H33NO6S2/c1-3-4-25(17-33(35)36)26-6-10-32(34-18-26)40-20-24-5-9-31-29(16-24)30(21-41-31)28-8-7-27(15-22(28)2)39-19-23-11-13-42(37,38)14-12-23/h5-10,15-16,18,21,23,25H,11-14,17,19-20H2,1-2H3,(H,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300888
PNG
((3S)-3-[4-[([3-[2-Methyl-4- (tetrahydrofuran-3- yl...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OC5CCOC5)cc4C)c3c2)cc1
Show InChI InChI=1S/C32H30O5S/c1-3-4-24(16-32(33)34)23-7-5-22(6-8-23)18-36-25-10-12-31-29(17-25)30(20-38-31)28-11-9-26(15-21(28)2)37-27-13-14-35-19-27/h5-12,15,17,20,24,27H,13-14,16,18-19H2,1-2H3,(H,33,34)/t24-,27?/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300894
PNG
((3R)-3-(6-((3-(5-(2- Methoxyethoxy)-2- methylpyrid...)
Show SMILES COCCOc1cnc(C)c(c1)-c1csc2ccc(COc3ccc(cn3)[C@H](CC(O)=O)C#CC)cc12
Show InChI InChI=1S/C29H28N2O5S/c1-4-5-21(13-29(32)33)22-7-9-28(31-15-22)36-17-20-6-8-27-25(12-20)26(18-37-27)24-14-23(16-30-19(24)2)35-11-10-34-3/h6-9,12,14-16,18,21H,10-11,13,17H2,1-3H3,(H,32,33)/t21-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM300895
PNG
((3S)-3-(4-((3-(6-Chloro-3- methylpyridin-2- yl)ben...)
Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4nc(Cl)ccc4C)c3c2)cc1
Show InChI InChI=1S/C27H22ClNO3S/c1-3-4-20(14-26(30)31)19-7-9-21(10-8-19)32-15-18-6-11-24-22(13-18)23(16-33-24)27-17(2)5-12-25(28)29-27/h5-13,16,20H,14-15H2,1-2H3,(H,30,31)/t20-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...


US Patent US10131648 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%