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Patent code US10131664

Compile Data Set for Download or QSAR
Found 178 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301025
PNG
(4-[5-(4-fluorophenyl)-2-{[(3S)- pyrrolidin-3- ylme...)
Show SMILES Fc1ccc(cc1)-c1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20FN5/c23-19-7-5-17(6-8-19)20-14-27-22(26-13-16-9-10-25-12-16)28-21(20)18-3-1-15(11-24)2-4-18/h1-8,14,16,25H,9-10,12-13H2,(H,26,27,28)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301035
PNG
((+-)-4-(2-{[(3-fluoropyrrolidin-3- yl)methyl]amino...)
Show SMILES Cc1ccc(cc1)-c1cnc(NCC2(F)CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22FN5/c1-16-2-6-18(7-3-16)20-13-27-22(28-15-23(24)10-11-26-14-23)29-21(20)19-8-4-17(12-25)5-9-19/h2-9,13,26H,10-11,14-15H2,1H3,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301066
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylindazol-5...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H22FN7/c1-31-14-18-10-15(4-5-22(18)30-31)20-13-28-24(32-8-6-19(27)7-9-32)29-23(20)16-2-3-17(12-26)21(25)11-16/h2-5,10-11,13-14,19H,6-9,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301075
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylpyrazolo[...)
Show SMILES Cn1ncc2cc(ncc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-21-14-26-20(10-17(21)12-28-30)19-13-27-23(31-8-6-18(25)7-9-31)29-22(19)16-4-2-15(11-24)3-5-16/h2-5,10,12-14,18H,6-9,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301094
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylbenzimida...)
Show SMILES Cn1cnc2cc(ccc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H22FN7/c1-31-14-29-21-11-15(4-5-22(21)31)19-13-28-24(32-8-6-18(27)7-9-32)30-23(19)16-2-3-17(12-26)20(25)10-16/h2-5,10-11,13-14,18H,6-9,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301137
PNG
(4-[2-(2,3,3a,4,5,7,8,8a-octahydro-1H- pyrrolo[3,4-...)
Show SMILES Cn1cnc2cc(c(F)c(F)c12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2CNCC2CC1
Show InChI InChI=1S/C27H25F2N7/c1-35-15-33-22-10-20(23(28)24(29)26(22)35)21-14-32-27(34-25(21)17-4-2-16(11-30)3-5-17)36-8-6-18-12-31-13-19(18)7-9-36/h2-5,10,14-15,18-19,31H,6-9,12-13H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301146
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3- methyltriazolo[...)
Show SMILES Cn1nnc2cc(cnc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H20FN9/c1-31-21-19(29-30-31)9-15(11-26-21)17-12-27-22(32-6-4-16(25)5-7-32)28-20(17)13-2-3-14(10-24)18(23)8-13/h2-3,8-9,11-12,16H,4-7,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301151
PNG
(4-[2-(6-amino-3- azabicyclo[3.1.0]hexan-3-yl)-5-(2...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)C1
Show InChI InChI=1S/C23H20FN7/c1-30-12-17-8-14(4-5-21(17)29-30)19-11-27-23(31-7-6-18(26)13-31)28-22(19)15-2-3-16(10-25)20(24)9-15/h2-5,8-9,11-12,18H,6-7,13,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301153
PNG
(4-[2-(2,3,3a,4,5,7,8,8a-octahydro-1H- pyrrolo[3,4-...)
Show SMILES N#Cc1ccc(cc1)-c1nc(ncc1-c1ccc2scnc2c1)N1CCC2CNCC2CC1
Show InChI InChI=1S/C26H24N6S/c27-12-17-1-3-18(4-2-17)25-22(19-5-6-24-23(11-19)30-16-33-24)15-29-26(31-25)32-9-7-20-13-28-14-21(20)8-10-32/h1-6,11,15-16,20-21,28H,7-10,13-14H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301155
PNG
(4-[2-(1,4-diazepan-1-yl)-6-methoxy-5- (2-methyl-2H...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2nn(C)cc2c1)N1CCCNCC1
Show InChI InChI=1S/C25H24FN7O/c1-32-15-19-12-16(6-7-21(19)31-32)22-23(17-4-5-18(14-27)20(26)13-17)29-25(30-24(22)34-2)33-10-3-8-28-9-11-33/h4-7,12-13,15,28H,3,8-11H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301174
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- (methylamino)-5-[1...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1cnn(CC(F)(F)F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H22F4N8/c1-29-20-18(15-10-30-34(11-15)12-22(24,25)26)19(13-2-3-14(9-27)17(23)8-13)31-21(32-20)33-6-4-16(28)5-7-33/h2-3,8,10-11,16H,4-7,12,28H2,1H3,(H,29,31,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301175
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2- (dimethylamino)...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1cnc(nc1)N(C)C)N1CCC(N)CC1
Show InChI InChI=1S/C23H26FN9/c1-27-21-19(16-12-28-22(29-13-16)32(2)3)20(14-4-5-15(11-25)18(24)10-14)30-23(31-21)33-8-6-17(26)7-9-33/h4-5,10,12-13,17H,6-9,26H2,1-3H3,(H,27,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301182
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-{1- methyl-1H-pyraz...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1cnc2n(C)ncc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H24FN9/c1-28-22-20(16-9-17-13-30-33(2)23(17)29-12-16)21(14-3-4-15(11-26)19(25)10-14)31-24(32-22)34-7-5-18(27)6-8-34/h3-4,9-10,12-13,18H,5-8,27H2,1-2H3,(H,28,31,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301184
PNG
(4-{2-[(3S,4R)-4-amino-3- fluoropiperidin-1-yl]-5-(...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc2nn(C)cc2c1)N1CC[C@@H](N)[C@@H](F)C1
Show InChI InChI=1S/C25H25FN8/c1-29-24-22(17-7-8-21-18(11-17)13-33(2)32-21)23(16-5-3-15(12-27)4-6-16)30-25(31-24)34-10-9-20(28)19(26)14-34/h3-8,11,13,19-20H,9-10,14,28H2,1-2H3,(H,29,30,31)/t19-,20+/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301010
PNG
(4-[5-(4-methylphenyl)-1-[[(3S)- pyrrolidin-3-yl]me...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(C[C@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N4/c1-18-2-6-22(7-3-18)26-23(21-8-4-19(15-27)5-9-21)14-25-24(29-26)11-13-30(25)17-20-10-12-28-16-20/h2-9,11,13-14,20,28H,10,12,16-17H2,1H3/t20-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301012
PNG
(4-[5-(4-fluorophenyl)-1-[[(3S)- pyrrolidin-3-yl]me...)
Show SMILES Fc1ccc(cc1)-c1nc2ccn(C[C@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H21FN4/c26-21-7-5-20(6-8-21)25-22(19-3-1-17(14-27)2-4-19)13-24-23(29-25)10-12-30(24)16-18-9-11-28-15-18/h1-8,10,12-13,18,28H,9,11,15-16H2/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301014
PNG
(4-[5-morpholin-4-yl-1-[[(3S)- pyrrolidin-3-yl]meth...)
Show SMILES N#Cc1ccc(cc1)-c1cc2n(C[C@H]3CCNC3)ccc2nc1N1CCOCC1
Show InChI InChI=1S/C23H25N5O/c24-14-17-1-3-19(4-2-17)20-13-22-21(26-23(20)27-9-11-29-12-10-27)6-8-28(22)16-18-5-7-25-15-18/h1-4,6,8,13,18,25H,5,7,9-12,15-16H2/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301018
PNG
(4-[5-(4-fluorophenyl)-1-[[(2R)- morpholin-2-yl]met...)
Show SMILES Fc1ccc(cc1)-c1nc2ccn(C[C@H]3CNCCO3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H21FN4O/c26-20-7-5-19(6-8-20)25-22(18-3-1-17(14-27)2-4-18)13-24-23(29-25)9-11-30(24)16-21-15-28-10-12-31-21/h1-9,11,13,21,28H,10,12,15-16H2/t21-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301032
PNG
(4-(2-{[(3S)-pyrrolidin-3- ylmethyl]amino}-5-[4- (t...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H20F3N5/c24-23(25,26)19-7-5-17(6-8-19)20-14-30-22(29-13-16-9-10-28-12-16)31-21(20)18-3-1-15(11-27)2-4-18/h1-8,14,16,28H,9-10,12-13H2,(H,29,30,31)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301038
PNG
((+-)-4-[5-(4-methylphenyl)-2- [(piperidin-3- ylmet...)
Show SMILES Cc1ccc(cc1)-c1cnc(NCC2CCCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5/c1-17-4-8-20(9-5-17)22-16-28-24(27-15-19-3-2-12-26-14-19)29-23(22)21-10-6-18(13-25)7-11-21/h4-11,16,19,26H,2-3,12,14-15H2,1H3,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301042
PNG
(4-(2-{2,7-diazaspiro[4.4]nonan-2-yl}- 5-(4-methylp...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2(CCNC2)C1
Show InChI InChI=1S/C25H25N5/c1-18-2-6-20(7-3-18)22-15-28-24(30-13-11-25(17-30)10-12-27-16-25)29-23(22)21-8-4-19(14-26)5-9-21/h2-9,15,27H,10-13,16-17H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301051
PNG
(4-[5-(4-methylphenyl)-3-[[(3S)- pyrrolidin-3-yl]me...)
Show SMILES Cc1ccc(cc1)-c1cc(NC[C@H]2CCNC2)nn1-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H23N5/c1-16-2-6-19(7-3-16)21-12-22(25-15-18-10-11-24-14-18)26-27(21)20-8-4-17(13-23)5-9-20/h2-9,12,18,24H,10-11,14-15H2,1H3,(H,25,26)/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301061
PNG
(4-[5-morpholin-4-yl-1-[[(3R)- pyrrolidin-3-yl]meth...)
Show SMILES COc1ccc(cc1)-c1nc2ccn(C[C@H]3CCNC3)c2cc1-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H23FN4O/c1-32-21-6-4-18(5-7-21)26-22(19-2-3-20(14-28)23(27)12-19)13-25-24(30-26)9-11-31(25)16-17-8-10-29-15-17/h2-7,9,11-13,17,29H,8,10,15-16H2,1H3/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301067
PNG
(4-[2-(1,2,3,3a,4,6,7,7a- octahydropyrrolo[3,2-c]py...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2NCCC2C1
Show InChI InChI=1S/C25H25N5/c1-17-2-6-19(7-3-17)22-15-28-25(30-13-11-23-21(16-30)10-12-27-23)29-24(22)20-8-4-18(14-26)5-9-20/h2-9,15,21,23,27H,10-13,16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301070
PNG
(4-[2-(1,2,3,3a,4,6,7,7a- octahydropyrrolo[3,2-c]py...)
Show SMILES FC(F)(F)Cn1cc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2NCCC2C1
Show InChI InChI=1S/C23H22F3N7/c24-23(25,26)14-33-13-18(10-30-33)19-11-29-22(32-8-6-20-17(12-32)5-7-28-20)31-21(19)16-3-1-15(9-27)2-4-16/h1-4,10-11,13,17,20,28H,5-8,12,14H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301089
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(4- methylphenyl)py...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H23N5/c1-16-2-6-18(7-3-16)21-15-26-23(28-12-10-20(25)11-13-28)27-22(21)19-8-4-17(14-24)5-9-19/h2-9,15,20H,10-13,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301090
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(4- methoxyphenyl)p...)
Show SMILES COc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H23N5O/c1-29-20-8-6-17(7-9-20)21-15-26-23(28-12-10-19(25)11-13-28)27-22(21)18-4-2-16(14-24)3-5-18/h2-9,15,19H,10-13,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301091
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3- fluoro-4-methox...)
Show SMILES COc1ccc(cc1F)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22FN5O/c1-30-21-7-6-17(12-20(21)24)19-14-27-23(29-10-8-18(26)9-11-29)28-22(19)16-4-2-15(13-25)3-5-16/h2-7,12,14,18H,8-11,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301097
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylpyrimidin...)
Show SMILES Cc1ncc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C21H21N7/c1-14-24-11-17(12-25-14)19-13-26-21(28-8-6-18(23)7-9-28)27-20(19)16-4-2-15(10-22)3-5-16/h2-5,11-13,18H,6-9,23H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301112
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(6- fluoro-1-methyl...)
Show SMILES Cn1nnc2cc(c(F)cc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H20F2N8/c1-32-21-10-19(25)16(9-20(21)30-31-32)17-12-28-23(33-6-4-15(27)5-7-33)29-22(17)13-2-3-14(11-26)18(24)8-13/h2-3,8-10,12,15H,4-7,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301113
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(2- methylpyrazo...)
Show SMILES Cn1nccc1C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H20FN7/c1-29-19(6-9-27-29)5-4-17-14-26-22(30-10-7-18(25)8-11-30)28-21(17)15-2-3-16(13-24)20(23)12-15/h2-3,6,9,12,14,18H,7-8,10-11,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301123
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylindazol-5...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C24H23N7/c1-30-22-7-6-18(12-19(22)14-28-30)21-15-27-24(31-10-8-20(26)9-11-31)29-23(21)17-4-2-16(13-25)3-5-17/h2-7,12,14-15,20H,8-11,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301141
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2- (dimethylamino)...)
Show SMILES CN(C)c1ncc(cn1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H23FN8/c1-30(2)21-26-11-16(12-27-21)18-13-28-22(31-7-5-17(25)6-8-31)29-20(18)14-3-4-15(10-24)19(23)9-14/h3-4,9,11-13,17H,5-8,25H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301150
PNG
(4-[2-(3-aminopyrrolidin-1-yl)-5-(2- methylindazol-...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)C1
Show InChI InChI=1S/C23H20FN7/c1-30-12-17-8-14(4-5-21(17)29-30)19-11-27-23(31-7-6-18(26)13-31)28-22(19)15-2-3-16(10-25)20(24)9-15/h2-5,8-9,11-12,18H,6-7,13,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301159
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-(2-methy...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc2nn(C)cc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H25N7O/c1-31-15-19-13-18(7-8-21(19)30-31)22-23(17-5-3-16(14-26)4-6-17)28-25(29-24(22)33-2)32-11-9-20(27)10-12-32/h3-8,13,15,20H,9-12,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301168
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methyl-1H-indaz...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1C1=CC2C=NN(C)C2C=C1)N1CCC(N)CC1
Show InChI InChI=1S/C25H27FN8/c1-29-24-22(15-5-6-21-18(11-15)14-30-33(21)2)23(16-3-4-17(13-27)20(26)12-16)31-25(32-24)34-9-7-19(28)8-10-34/h3-6,11-12,14,18-19,21H,7-10,28H2,1-2H3,(H,29,31,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301180
PNG
(4-{2-[4-(dimethylamino)piperidin-1- yl]-5-(2-methy...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc2nn(C)cc2c1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C27H30N8/c1-29-26-24(20-9-10-23-21(15-20)17-34(4)32-23)25(19-7-5-18(16-28)6-8-19)30-27(31-26)35-13-11-22(12-14-35)33(2)3/h5-10,15,17,22H,11-14H2,1-4H3,(H,29,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301181
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- (methylamino)-5-[1...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1-c1cnn(CC(F)(F)F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H23F3N8/c1-28-20-18(16-11-29-33(12-16)13-22(23,24)25)19(15-4-2-14(10-26)3-5-15)30-21(31-20)32-8-6-17(27)7-9-32/h2-5,11-12,17H,6-9,13,27H2,1H3,(H,28,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301027
PNG
(4-[5-(4-methylphenyl)-2-[(3R)- pyrrolidin-3-ylmeth...)
Show SMILES Cc1ccc(cc1)-c1cnc(OC[C@@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22N4O/c1-16-2-6-19(7-3-16)21-14-26-23(28-15-18-10-11-25-13-18)27-22(21)20-8-4-17(12-24)5-9-20/h2-9,14,18,25H,10-11,13,15H2,1H3/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301031
PNG
(4-{2-[(3aR,8aS)-decahydropyrrolo[3,4- d]azepin-6-y...)
Show SMILES Fc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC[C@@H]2CNC[C@@H]2CC1
Show InChI InChI=1S/C25H24FN5/c26-22-7-5-18(6-8-22)23-16-29-25(30-24(23)19-3-1-17(13-27)2-4-19)31-11-9-20-14-28-15-21(20)10-12-31/h1-8,16,20-21,28H,9-12,14-15H2/t20-,21+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301050
PNG
(4-[5-(4-methylphenyl)-3-(pyrrolidin-3- ylmethylami...)
Show SMILES Cc1ccc(cc1)-c1cc(NCC2CCNC2)nn1-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H23N5/c1-16-2-6-19(7-3-16)21-12-22(25-15-18-10-11-24-14-18)26-27(21)20-8-4-17(13-23)5-9-20/h2-9,12,18,24H,10-11,14-15H2,1H3,(H,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301052
PNG
(4-[5-(4-methylphenyl)-3-[[(3R)- pyrrolidin-3-yl]me...)
Show SMILES Cc1ccc(cc1)-c1cc(NC[C@@H]2CCNC2)nn1-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H23N5/c1-16-2-6-19(7-3-16)21-12-22(25-15-18-10-11-24-14-18)26-27(21)20-8-4-17(13-23)5-9-20/h2-9,12,18,24H,10-11,14-15H2,1H3,(H,25,26)/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301054
PNG
(4-[3-[[(1S,5R)-3- azabicyclo[3.1.0]hexan-6- yl]met...)
Show SMILES Cc1ccc(cc1)-c1cc(NC[C@H]2[C@@H]3CNC[C@H]23)nn1-c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1S/C23H23N5/c1-15-3-5-16(6-4-15)22-11-23(26-14-21-19-12-25-13-20(19)21)27-28(22)18-9-7-17(24-2)8-10-18/h3-11,19-21,25H,12-14H2,1H3,(H,26,27)/t19-,20+,21+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301058
PNG
(4-{1-[((3S)pyrrolidin-3-yl)methyl]-5- (3-fluoro-4-...)
Show SMILES COc1ccc(cc1F)-c1nc2ccn(C[C@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H23FN4O/c1-32-25-7-6-20(12-22(25)27)26-21(19-4-2-17(14-28)3-5-19)13-24-23(30-26)9-11-31(24)16-18-8-10-29-15-18/h2-7,9,11-13,18,29H,8,10,15-16H2,1H3/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301076
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylpyrazolo[...)
Show SMILES Cn1ncc2cc(ncc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-21-14-26-20(10-17(21)12-28-30)19-13-27-23(31-8-6-18(25)7-9-31)29-22(19)16-4-2-15(11-24)3-5-16/h2-5,10,12-14,18H,6-9,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301096
PNG
(2-fluoro-4-[2-[4- (methylamino)piperidin-1-yl]-5-[...)
Show SMILES CNC1CCN(CC1)c1ncc(-c2cnn(CC(F)(F)F)c2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C22H21F4N7/c1-28-17-4-6-32(7-5-17)21-29-11-18(16-10-30-33(12-16)13-22(24,25)26)20(31-21)14-2-3-15(9-27)19(23)8-14/h2-3,8,10-12,17,28H,4-7,13H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301102
PNG
(4-[5-(3-amino-2-methylindazol-5-yl)- 2-(4-aminopip...)
Show SMILES Cn1nc2ccc(cc2c1N)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H23FN8/c1-32-23(28)18-10-14(4-5-21(18)31-32)19-13-29-24(33-8-6-17(27)7-9-33)30-22(19)15-2-3-16(12-26)20(25)11-15/h2-5,10-11,13,17H,6-9,27-28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301122
PNG
(4-[2-(1,2,3,3a,4,6,7,7a- octahydropyrrolo[3,4-c]py...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2CNCC2C1
Show InChI InChI=1S/C26H25N7/c1-32-24-7-6-19(10-21(24)14-30-32)23-15-29-26(33-9-8-20-12-28-13-22(20)16-33)31-25(23)18-4-2-17(11-27)3-5-18/h2-7,10,14-15,20,22,28H,8-9,12-13,16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301132
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(6- fluoro-1-methyl...)
Show SMILES Cn1cnc2cc(c(F)cc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C24H22FN7/c1-31-14-29-21-10-18(20(25)11-22(21)31)19-13-28-24(32-8-6-17(27)7-9-32)30-23(19)16-4-2-15(12-26)3-5-16/h2-5,10-11,13-14,17H,6-9,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301135
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylindazol-5...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C24H23N7/c1-30-15-19-12-18(6-7-22(19)29-30)21-14-27-24(31-10-8-20(26)9-11-31)28-23(21)17-4-2-16(13-25)3-5-17/h2-7,12,14-15,20H,8-11,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301136
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylindazol-6...)
Show SMILES Cn1cc2ccc(cc2n1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C24H23N7/c1-30-15-19-7-6-18(12-22(19)29-30)21-14-27-24(31-10-8-20(26)9-11-31)28-23(21)17-4-2-16(13-25)3-5-17/h2-7,12,14-15,20H,8-11,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301162
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[6- (dimethylamino)...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc(nc1)N(C)C)N1CCC(N)CC1
Show InChI InChI=1S/C24H27N7O/c1-30(2)20-9-8-18(15-27-20)21-22(17-6-4-16(14-25)5-7-17)28-24(29-23(21)32-3)31-12-10-19(26)11-13-31/h4-9,15,19H,10-13,26H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301166
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-{1-methy...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1cnc2n(C)ncc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H23FN8O/c1-32-22-17(13-29-32)9-16(12-28-22)20-21(14-3-4-15(11-26)19(25)10-14)30-24(31-23(20)34-2)33-7-5-18(27)6-8-33/h3-4,9-10,12-13,18H,5-8,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301173
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- (ethylamino)-5-(2-...)
Show SMILES CCNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2nn(C)cc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C26H27FN8/c1-3-30-25-23(16-6-7-22-19(12-16)15-34(2)33-22)24(17-4-5-18(14-28)21(27)13-17)31-26(32-25)35-10-8-20(29)9-11-35/h4-7,12-13,15,20H,3,8-11,29H2,1-2H3,(H,30,31,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301008
PNG
(4-[5-(4-methylphenyl)-1-[[(3R)- pyrrolidin-3-yl]me...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(C[C@@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N4/c1-18-2-6-22(7-3-18)26-23(21-8-4-19(15-27)5-9-21)14-25-24(29-26)11-13-30(25)17-20-10-12-28-16-20/h2-9,11,13-14,20,28H,10,12,16-17H2,1H3/t20-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301016
PNG
(4-[1-[(3-fluoropyrrolidin-3-yl)methyl]- 5-(4-methy...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(CC3(F)CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H23FN4/c1-18-2-6-21(7-3-18)25-22(20-8-4-19(15-28)5-9-20)14-24-23(30-25)10-13-31(24)17-26(27)11-12-29-16-26/h2-10,13-14,29H,11-12,16-17H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301022
PNG
(4-[1-[[(1S,5R)-3- azabicyclo[3.1.0]hexan-6-yl]meth...)
Show SMILES Cc1ccc(cc1)-c1nc2cnn(C[C@H]3[C@@H]4CNC[C@H]34)c2cc1-c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1S/C26H23N5/c1-16-3-5-18(6-4-16)26-20(17-7-9-19(27-2)10-8-17)11-25-24(30-26)14-29-31(25)15-23-21-12-28-13-22(21)23/h3-11,14,21-23,28H,12-13,15H2,1H3/t21-,22+,23+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301028
PNG
(4-{2-[(3aR,6aS)-octahydropyrrolo[3,4- c]pyrrol-2-y...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1S/C24H23N5/c1-16-2-6-18(7-3-16)22-13-27-24(29-14-20-11-26-12-21(20)15-29)28-23(22)19-8-4-17(10-25)5-9-19/h2-9,13,20-21,26H,11-12,14-15H2,1H3/t20-,21+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301033
PNG
(4-[5-(2-cyclopropylethynyl)-2-{[(3S)- pyrrolidin-3...)
Show SMILES N#Cc1ccc(cc1)-c1nc(NC[C@H]2CCNC2)ncc1C#CC1CC1
Show InChI InChI=1S/C21H21N5/c22-11-16-4-6-18(7-5-16)20-19(8-3-15-1-2-15)14-25-21(26-20)24-13-17-9-10-23-12-17/h4-7,14-15,17,23H,1-2,9-10,12-13H2,(H,24,25,26)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301036
PNG
((+-)-4-[5-(4-methylphenyl)-2- [(piperidin-3-yl)ami...)
Show SMILES Cc1ccc(cc1)-c1cnc(NC2CCCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5/c1-16-4-8-18(9-5-16)21-15-26-23(27-20-3-2-12-25-14-20)28-22(21)19-10-6-17(13-24)7-11-19/h4-11,15,20,25H,2-3,12,14H2,1H3,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301040
PNG
((+-)-4-[5-(4-methylphenyl)-2- [(morpholin-2- ylmet...)
Show SMILES Cc1ccc(cc1)-c1cnc(NCC2CNCCO2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5O/c1-16-2-6-18(7-3-16)21-15-27-23(26-14-20-13-25-10-11-29-20)28-22(21)19-8-4-17(12-24)5-9-19/h2-9,15,20,25H,10-11,13-14H2,1H3,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301044
PNG
(4-[5-(4-methylphenyl)-2-{octahydro- 1H-pyrrolo[3,4...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC2CCNCC2C1
Show InChI InChI=1S/C25H25N5/c1-17-2-6-19(7-3-17)23-14-28-25(30-15-21-10-11-27-13-22(21)16-30)29-24(23)20-8-4-18(12-26)5-9-20/h2-9,14,21-22,27H,10-11,13,15-16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301065
PNG
(4-{3-[((3R)-3-aminopiperidyl) carbonyl]-5-(4-pyrid...)
Show SMILES N[C@@H]1CCCN(C1)C(=O)c1cc(OCc2ccncc2)n(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H22N6O2/c23-13-16-3-5-19(6-4-16)28-21(30-15-17-7-9-25-10-8-17)12-20(26-28)22(29)27-11-1-2-18(24)14-27/h3-10,12,18H,1-2,11,14-15,24H2/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301083
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylpyrazolo[...)
Show SMILES Cn1cc2ncc(cc2n1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-14-21-20(29-30)10-17(12-26-21)19-13-27-23(31-8-6-18(25)7-9-31)28-22(19)16-4-2-15(11-24)3-5-16/h2-5,10,12-14,18H,6-9,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301084
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylpyrrolo[3...)
Show SMILES Cn1ccc2nc(ccc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C24H23N7/c1-30-11-10-21-22(30)7-6-20(28-21)19-15-27-24(31-12-8-18(26)9-13-31)29-23(19)17-4-2-16(14-25)3-5-17/h2-7,10-11,15,18H,8-9,12-13,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301099
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2,3- dimcthylindaz...)
Show SMILES Cc1n(C)nc2ccc(cc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H24FN7/c1-15-20-11-16(5-6-23(20)31-32(15)2)21-14-29-25(33-9-7-19(28)8-10-33)30-24(21)17-3-4-18(13-27)22(26)12-17/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301101
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(3- hydroxyoxola...)
Show SMILES NC1CCN(CC1)c1ncc(C#CC2(O)CCOC2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C22H22FN5O2/c23-19-11-15(1-2-16(19)12-24)20-17(3-6-22(29)7-10-30-14-22)13-26-21(27-20)28-8-4-18(25)5-9-28/h1-2,11,13,18,29H,4-5,7-10,14,25H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301105
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(3- methyltriazo...)
Show SMILES Cn1nncc1C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C21H19FN8/c1-29-18(13-26-28-29)5-4-16-12-25-21(30-8-6-17(24)7-9-30)27-20(16)14-2-3-15(11-23)19(22)10-14/h2-3,10,12-13,17H,6-9,24H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301114
PNG
(4-[2-(4-amino-3-hydroxypiperidin-1- yl)-5-(2-methy...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)C(O)C1
Show InChI InChI=1S/C24H22FN7O/c1-31-12-17-8-14(4-5-21(17)30-31)18-11-28-24(32-7-6-20(27)22(33)13-32)29-23(18)15-2-3-16(10-26)19(25)9-15/h2-5,8-9,11-12,20,22,33H,6-7,13,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301117
PNG
(4-[2-(1,4-diazepan-1-yl)-5-(2- methylindazol-5-yl)...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCCNCC1
Show InChI InChI=1S/C24H22FN7/c1-31-15-19-11-16(5-6-22(19)30-31)20-14-28-24(32-9-2-7-27-8-10-32)29-23(20)17-3-4-18(13-26)21(25)12-17/h3-6,11-12,14-15,27H,2,7-10H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301119
PNG
(4-[2-(4-amino-3-fluoropiperidin-1-yl)- 5-(2-methyl...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)C(F)C1
Show InChI InChI=1S/C24H21F2N7/c1-32-12-17-8-14(4-5-22(17)31-32)18-11-29-24(33-7-6-21(28)20(26)13-33)30-23(18)15-2-3-16(10-27)19(25)9-15/h2-5,8-9,11-12,20-21H,6-7,13,28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301121
PNG
(4-[2-(2,3,3a,4,5,7,8,8a-octahydro-1H- pyrrolo[3,4-...)
Show SMILES Cc1ccc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2CNCC2CC1
Show InChI InChI=1S/C25H26N6/c1-17-2-5-22(15-28-17)23-16-29-25(30-24(23)19-6-3-18(12-26)4-7-19)31-10-8-20-13-27-14-21(20)9-11-31/h2-7,15-16,20-21,27H,8-11,13-14H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301127
PNG
(4-[2-(3,7-diazabicyclo[3.3.1]nonan-3- yl)-5-(1-met...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC2CNCC(C2)C1
Show InChI InChI=1S/C26H25N7/c1-32-24-7-6-21(9-22(24)13-30-32)23-14-29-26(33-15-18-8-19(16-33)12-28-11-18)31-25(23)20-4-2-17(10-27)3-5-20/h2-7,9,13-14,18-19,28H,8,11-12,15-16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301129
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylbenzimida...)
Show SMILES Cn1cnc2cc(ccc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C24H23N7/c1-30-15-28-21-12-18(6-7-22(21)30)20-14-27-24(31-10-8-19(26)9-11-31)29-23(20)17-4-2-16(13-25)3-5-17/h2-7,12,14-15,19H,8-11,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301131
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[6- (cyclopropylmet...)
Show SMILES NC1CCN(CC1)c1ncc(-c2ccc(OCC3CC3)nc2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H26N6O/c26-13-17-3-5-19(6-4-17)24-22(15-29-25(30-24)31-11-9-21(27)10-12-31)20-7-8-23(28-14-20)32-16-18-1-2-18/h3-8,14-15,18,21H,1-2,9-12,16,27H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301143
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3- methylimidazo[4...)
Show SMILES Cn1cnc2cc(cnc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H21FN8/c1-31-13-29-20-9-16(11-27-22(20)31)18-12-28-23(32-6-4-17(26)5-7-32)30-21(18)14-2-3-15(10-25)19(24)8-14/h2-3,8-9,11-13,17H,4-7,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301144
PNG
(4-[2-(2,8-diazaspiro[4.5]decan-8-yl)-5- (3-methyli...)
Show SMILES Cn1cnc2cc(cnc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC2(CCNC2)CC1
Show InChI InChI=1S/C26H25FN8/c1-34-16-32-22-11-19(13-30-24(22)34)20-14-31-25(35-8-5-26(6-9-35)4-7-29-15-26)33-23(20)17-2-3-18(12-28)21(27)10-17/h2-3,10-11,13-14,16,29H,4-9,15H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301160
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-[1-(2,2,...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1cnn(CC(F)(F)F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H22F3N7O/c1-33-20-18(16-11-28-32(12-16)13-22(23,24)25)19(15-4-2-14(10-26)3-5-15)29-21(30-20)31-8-6-17(27)7-9-31/h2-5,11-12,17H,6-9,13,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301170
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methyl-2H-indaz...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc2nn(C)cc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H26N8/c1-28-24-22(18-7-8-21-19(13-18)15-32(2)31-21)23(17-5-3-16(14-26)4-6-17)29-25(30-24)33-11-9-20(27)10-12-33/h3-8,13,15,20H,9-12,27H2,1-2H3,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301179
PNG
(4-[2-(1,4-diazepan-1-yl)-5-(2-methyl- 2H-indazol-5...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc2nn(C)cc2c1)N1CCCNCC1
Show InChI InChI=1S/C25H26N8/c1-27-24-22(19-8-9-21-20(14-19)16-32(2)31-21)23(18-6-4-17(15-26)5-7-18)29-25(30-24)33-12-3-10-28-11-13-33/h4-9,14,16,28H,3,10-13H2,1-2H3,(H,27,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50158880
PNG
(CHEMBL3785783 | US10131664, Example 16)
Show SMILES Cc1ccc(cc1)-c1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5/c1-16-2-6-19(7-3-16)21-15-27-23(26-14-18-10-11-25-13-18)28-22(21)20-8-4-17(12-24)5-9-20/h2-9,15,18,25H,10-11,13-14H2,1H3,(H,26,27,28)/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301030
PNG
(4-{2-[(3aR,8aS)-decahydropyrrolo[3,4- d]azepin-6-y...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC[C@@H]2CNC[C@@H]2CC1
Show InChI InChI=1S/C26H27N5/c1-18-2-6-20(7-3-18)24-17-29-26(30-25(24)21-8-4-19(14-27)5-9-21)31-12-10-22-15-28-16-23(22)11-13-31/h2-9,17,22-23,28H,10-13,15-16H2,1H3/t22-,23+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301039
PNG
(4-[5-(4-methylphenyl)-2-[(piperidin-4- ylmethyl)am...)
Show SMILES Cc1ccc(cc1)-c1cnc(NCC2CCNCC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5/c1-17-2-6-20(7-3-17)22-16-28-24(27-15-19-10-12-26-13-11-19)29-23(22)21-8-4-18(14-25)5-9-21/h2-9,16,19,26H,10-13,15H2,1H3,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301046
PNG
(4-(2-{2,8-diazaspiro[4.5]decan-8-yl}- 5-(4-methylp...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2(CCNC2)CC1
Show InChI InChI=1S/C26H27N5/c1-19-2-6-21(7-3-19)23-17-29-25(30-24(23)22-8-4-20(16-27)5-9-22)31-14-11-26(12-15-31)10-13-28-18-26/h2-9,17,28H,10-15,18H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301047
PNG
(4-(2-{1,8-diazaspiro[4.5]decan-8-yl}- 5-(4-methylp...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2(CCCN2)CC1
Show InChI InChI=1S/C26H27N5/c1-19-3-7-21(8-4-19)23-18-28-25(30-24(23)22-9-5-20(17-27)6-10-22)31-15-12-26(13-16-31)11-2-14-29-26/h3-10,18,29H,2,11-16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301072
PNG
(4-[2-(2,3,3a,4,5,7,8,8a-octahydro-1H- pyrrolo[3,4-...)
Show SMILES Cn1ncc2cc(cnc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2CNCC2CC1
Show InChI InChI=1S/C26H26N8/c1-33-25-22(15-31-33)10-21(14-29-25)23-16-30-26(32-24(23)18-4-2-17(11-27)3-5-18)34-8-6-19-12-28-13-20(19)7-9-34/h2-5,10,14-16,19-20,28H,6-9,12-13H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301073
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3- methylimidazo[4...)
Show SMILES Cn1cnc2cc(cnc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-14-28-20-10-17(12-26-22(20)30)19-13-27-23(31-8-6-18(25)7-9-31)29-21(19)16-4-2-15(11-24)3-5-16/h2-5,10,12-14,18H,6-9,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301077
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- hydroxycyclo...)
Show SMILES NC1CCN(CC1)c1ncc(C#CC2(O)CCCC2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N5O/c24-15-17-3-5-18(6-4-17)21-19(7-12-23(29)10-1-2-11-23)16-26-22(27-21)28-13-8-20(25)9-14-28/h3-6,16,20,29H,1-2,8-11,13-14,25H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301079
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylbenzotria...)
Show SMILES Cn1nnc2cc(ccc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-21-7-6-17(12-20(21)28-29-30)19-14-26-23(31-10-8-18(25)9-11-31)27-22(19)16-4-2-15(13-24)3-5-16/h2-7,12,14,18H,8-11,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301104
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(4- hydroxyoxan-...)
Show SMILES NC1CCN(CC1)c1ncc(C#CC2(O)CCOCC2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H24FN5O2/c24-20-13-16(1-2-17(20)14-25)21-18(3-6-23(30)7-11-31-12-8-23)15-27-22(28-21)29-9-4-19(26)5-10-29/h1-2,13,15,19,30H,4-5,7-12,26H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301108
PNG
(4-[2-(4-amino-3-hydroxypiperidin-1- yl)-5-(1-methy...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)C(O)C1
Show InChI InChI=1S/C24H22FN7O/c1-31-21-5-4-14(8-17(21)11-29-31)18-12-28-24(32-7-6-20(27)22(33)13-32)30-23(18)15-2-3-16(10-26)19(25)9-15/h2-5,8-9,11-12,20,22,33H,6-7,13,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301111
PNG
(4-[2-(4-amino-3-hydroxypiperidin-1- yl)-5-(1-methy...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)C(O)C1
Show InChI InChI=1S/C24H22FN7O/c1-31-21-5-4-14(8-17(21)11-29-31)18-12-28-24(32-7-6-20(27)22(33)13-32)30-23(18)15-2-3-16(10-26)19(25)9-15/h2-5,8-9,11-12,20,22,33H,6-7,13,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301115
PNG
(4-[2-(3-aminopiperidin-1-yl)-5-(2- methylindazol-5...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCCC(N)C1
Show InChI InChI=1S/C24H22FN7/c1-31-13-18-9-15(6-7-22(18)30-31)20-12-28-24(32-8-2-3-19(27)14-32)29-23(20)16-4-5-17(11-26)21(25)10-16/h4-7,9-10,12-13,19H,2-3,8,14,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301126
PNG
(4-[2-(3,7-diazabicyclo[3.3.1]nonan-3- yl)-5-(4-met...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC2CNCC(C2)C1
Show InChI InChI=1S/C25H25N5/c1-17-2-6-21(7-3-17)23-14-28-25(30-15-19-10-20(16-30)13-27-12-19)29-24(23)22-8-4-18(11-26)5-9-22/h2-9,14,19-20,27H,10,12-13,15-16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301139
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(6,7- difluoro-1-me...)
Show SMILES Cn1cnc2cc(c(F)c(F)c12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H20F3N7/c1-33-12-31-19-9-16(20(26)21(27)23(19)33)17-11-30-24(34-6-4-15(29)5-7-34)32-22(17)13-2-3-14(10-28)18(25)8-13/h2-3,8-9,11-12,15H,4-7,29H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301145
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1,2- dimethylbenzi...)
Show SMILES Cc1nc2cc(ccc2n1C)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H24FN7/c1-15-30-22-12-16(5-6-23(22)32(15)2)20-14-29-25(33-9-7-19(28)8-10-33)31-24(20)17-3-4-18(13-27)21(26)11-17/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301147
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2- (methylamino)py...)
Show SMILES CNc1ncc(cn1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C21H21FN8/c1-25-20-26-10-15(11-27-20)17-12-28-21(30-6-4-16(24)5-7-30)29-19(17)13-2-3-14(9-23)18(22)8-13/h2-3,8,10-12,16H,4-7,24H2,1H3,(H,25,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301149
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[1- (oxan-4-yl)pyra...)
Show SMILES NC1CCN(CC1)c1ncc(-c2cnn(c2)C2CCOCC2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H26FN7O/c25-22-11-16(1-2-17(22)12-26)23-21(14-28-24(30-23)31-7-3-19(27)4-8-31)18-13-29-32(15-18)20-5-9-33-10-6-20/h1-2,11,13-15,19-20H,3-10,27H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301158
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-(1-methy...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H23FN8O/c1-32-20-6-5-14(12-19(20)30-31-32)21-22(15-3-4-16(13-26)18(25)11-15)28-24(29-23(21)34-2)33-9-7-17(27)8-10-33/h3-6,11-12,17H,7-10,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301161
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-(1-methy...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H24N8O/c1-31-20-8-7-17(13-19(20)29-30-31)21-22(16-5-3-15(14-25)4-6-16)27-24(28-23(21)33-2)32-11-9-18(26)10-12-32/h3-8,13,18H,9-12,26H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301176
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[6- (dimethylamino)...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc(nc1)N(C)C)N1CCC(N)CC1
Show InChI InChI=1S/C24H27FN8/c1-28-23-21(17-6-7-20(29-14-17)32(2)3)22(15-4-5-16(13-26)19(25)12-15)30-24(31-23)33-10-8-18(27)9-11-33/h4-7,12,14,18H,8-11,27H2,1-3H3,(H,28,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301177
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-{3- methyl-3H-[1,2,...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H25N9/c1-27-23-21(17-7-8-20-19(13-17)30-31-32(20)2)22(16-5-3-15(14-25)4-6-16)28-24(29-23)33-11-9-18(26)10-12-33/h3-8,13,18H,9-12,26H2,1-2H3,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301019
PNG
(4-[1-(3-aminopropyl)-5-(4- methylphenyl)pyrrolo[3,...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(CCCN)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H22N4/c1-17-3-7-20(8-4-17)24-21(19-9-5-18(16-26)6-10-19)15-23-22(27-24)11-14-28(23)13-2-12-25/h3-11,14-15H,2,12-13,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301020
PNG
(4-[5-(4-methylphenyl)-1-(pyrrolidin-3- ylmethyl)py...)
Show SMILES Cc1ccc(cc1)-c1nc2cnn(CC3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5/c1-17-2-6-21(7-3-17)25-22(20-8-4-18(13-26)5-9-20)12-24-23(29-25)15-28-30(24)16-19-10-11-27-14-19/h2-9,12,15,19,27H,10-11,14,16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301021
PNG
(4-[5-(4-methylphenyl)-1-(piperidin-4- ylmethyl)pyr...)
Show SMILES Cc1ccc(cc1)-c1nc2cnn(CC3CCNCC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25N5/c1-18-2-6-22(7-3-18)26-23(21-8-4-19(15-27)5-9-21)14-25-24(30-26)16-29-31(25)17-20-10-12-28-13-11-20/h2-9,14,16,20,28H,10-13,17H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301037
PNG
(4-[5-(4-methylphenyl)-2-[(piperidin-4- yl)amino]py...)
Show SMILES Cc1ccc(cc1)-c1cnc(NC2CCNCC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5/c1-16-2-6-18(7-3-16)21-15-26-23(27-20-10-12-25-13-11-20)28-22(21)19-8-4-17(14-24)5-9-19/h2-9,15,20,25H,10-13H2,1H3,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301043
PNG
(4-(2-{2,8-diazaspiro[4.5]decan-2-yl}- 5-(4-methylp...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2(C1)CCNCC2
Show InChI InChI=1S/C26H27N5/c1-19-2-6-21(7-3-19)23-17-29-25(30-24(23)22-8-4-20(16-27)5-9-22)31-15-12-26(18-31)10-13-28-14-11-26/h2-9,17,28H,10-15,18H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301045
PNG
(4-[5-(4-methylphenyl)-2-{octahydro- 1H-pyrrolo[3,2...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2NCCC2C1
Show InChI InChI=1S/C25H25N5/c1-17-2-6-19(7-3-17)22-15-28-25(30-13-11-23-21(16-30)10-12-27-23)29-24(22)20-8-4-18(14-26)5-9-20/h2-9,15,21,23,27H,10-13,16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301062
PNG
(4-{1-[((3R)pyrrolidin-3-yl)methyl]-5- (3-fluoro-4-...)
Show SMILES COc1ccc(cc1F)-c1nc2ccn(C[C@H]3CCNC3)c2cc1-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H22F2N4O/c1-33-25-5-4-18(11-22(25)28)26-20(17-2-3-19(13-29)21(27)10-17)12-24-23(31-26)7-9-32(24)15-16-6-8-30-14-16/h2-5,7,9-12,16,30H,6,8,14-15H2,1H3/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301063
PNG
(4-{3-[((3R)-3- aminopiperidyl)carbonyl]-5-(2- pyri...)
Show SMILES N[C@@H]1CCCN(C1)C(=O)c1cc(OCc2ccccn2)n(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H22N6O2/c23-13-16-6-8-19(9-7-16)28-21(30-15-18-5-1-2-10-25-18)12-20(26-28)22(29)27-11-3-4-17(24)14-27/h1-2,5-10,12,17H,3-4,11,14-15,24H2/t17-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301069
PNG
(4-[2-(2,8-diazaspiro[4.5]decan-8-yl)-5- [1-(2,2,2-...)
Show SMILES FC(F)(F)Cn1cc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2(CCNC2)CC1
Show InChI InChI=1S/C24H24F3N7/c25-24(26,27)16-34-14-19(12-31-34)20-13-30-22(32-21(20)18-3-1-17(11-28)2-4-18)33-9-6-23(7-10-33)5-8-29-15-23/h1-4,12-14,29H,5-10,15-16H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301074
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylpyrazolo[...)
Show SMILES Cn1ncc2nc(ccc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-21-7-6-19(28-20(21)14-27-30)18-13-26-23(31-10-8-17(25)9-11-31)29-22(18)16-4-2-15(12-24)3-5-16/h2-7,13-14,17H,8-11,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301078
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[1- (oxolan-3-yl)py...)
Show SMILES NC1CCN(CC1)c1ncc(-c2cnn(c2)C2CCOC2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N7O/c24-11-16-1-3-17(4-2-16)22-21(18-12-27-30(14-18)20-7-10-31-15-20)13-26-23(28-22)29-8-5-19(25)6-9-29/h1-4,12-14,19-20H,5-10,15,25H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301085
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[1- (oxolan-3-ylmet...)
Show SMILES NC1CCN(CC1)c1ncc(-c2cnn(CC3CCOC3)c2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H27N7O/c25-11-17-1-3-19(4-2-17)23-22(13-27-24(29-23)30-8-5-21(26)6-9-30)20-12-28-31(15-20)14-18-7-10-32-16-18/h1-4,12-13,15,18,21H,5-10,14,16,26H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301092
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylpyrazolo[...)
Show SMILES Cn1cc2cc(cnc2n1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-14-18-10-17(12-26-22(18)29-30)20-13-27-23(31-8-6-19(25)7-9-31)28-21(20)16-4-2-15(11-24)3-5-16/h2-5,10,12-14,19H,6-9,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301124
PNG
(4-[2-(2,3,3a,4,5,7,8,8a-octahydro-1H- pyrrolo[3,4-...)
Show SMILES N#Cc1ccc(cc1)-c1nc(ncc1-c1ccc2cn[nH]c2c1)N1CCC2CNCC2CC1
Show InChI InChI=1S/C26H25N7/c27-12-17-1-3-18(4-2-17)25-23(19-5-6-22-15-30-32-24(22)11-19)16-29-26(31-25)33-9-7-20-13-28-14-21(20)8-10-33/h1-6,11,15-16,20-21,28H,7-10,13-14H2,(H,30,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301128
PNG
(4-[2-(2,8-diazaspiro[4.5]decan-8-yl)-5- [1-(2,2,2-...)
Show SMILES FC(F)(F)Cn1cc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2(CCNC2)CC1
Show InChI InChI=1S/C24H24F3N7/c25-24(26,27)16-34-14-19(12-31-34)20-13-30-22(32-21(20)18-3-1-17(11-28)2-4-18)33-9-6-23(7-10-33)5-8-29-15-23/h1-4,12-14,29H,5-10,15-16H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301130
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(6- methoxypyridin-...)
Show SMILES COc1ccc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C22H22N6O/c1-29-20-7-6-17(13-25-20)19-14-26-22(28-10-8-18(24)9-11-28)27-21(19)16-4-2-15(12-23)3-5-16/h2-7,13-14,18H,8-11,24H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301133
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(6,7- difluoro-1-me...)
Show SMILES Cn1cnc2cc(c(F)c(F)c12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C24H21F2N7/c1-32-13-30-19-10-17(20(25)21(26)23(19)32)18-12-29-24(33-8-6-16(28)7-9-33)31-22(18)15-4-2-14(11-27)3-5-15/h2-5,10,12-13,16H,6-9,28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301140
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(6- fluoro-1-methyl...)
Show SMILES Cn1cnc2cc(c(F)cc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H21F2N7/c1-32-13-30-21-9-17(20(26)10-22(21)32)18-12-29-24(33-6-4-16(28)5-7-33)31-23(18)14-2-3-15(11-27)19(25)8-14/h2-3,8-10,12-13,16H,4-7,28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301142
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- pyrrolidin-1-yl...)
Show SMILES NC1CCN(CC1)c1ncc(-c2cnc(nc2)N2CCCC2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H25FN8/c25-21-11-16(3-4-17(21)12-26)22-20(15-30-24(31-22)33-9-5-19(27)6-10-33)18-13-28-23(29-14-18)32-7-1-2-8-32/h3-4,11,13-15,19H,1-2,5-10,27H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301167
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methyl-2H-indaz...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2nn(C)cc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H25FN8/c1-29-24-22(15-5-6-21-18(11-15)14-33(2)32-21)23(16-3-4-17(13-27)20(26)12-16)30-25(31-24)34-9-7-19(28)8-10-34/h3-6,11-12,14,19H,7-10,28H2,1-2H3,(H,29,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301169
PNG
(4-[2-(1,4-diazepan-1-yl)-5-(2-methyl- 2H-indazol-5...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2nn(C)cc2c1)N1CCCNCC1
Show InChI InChI=1S/C25H25FN8/c1-28-24-22(16-6-7-21-19(12-16)15-33(2)32-21)23(17-4-5-18(14-27)20(26)13-17)30-25(31-24)34-10-3-8-29-9-11-34/h4-7,12-13,15,29H,3,8-11H2,1-2H3,(H,28,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301171
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methyl-1H-indaz...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1C1=CC2C=NN(C)C2C=C1)N1CCC(N)CC1
Show InChI InChI=1S/C25H28N8/c1-28-24-22(18-7-8-21-19(13-18)15-29-32(21)2)23(17-5-3-16(14-26)4-6-17)30-25(31-24)33-11-9-20(27)10-12-33/h3-8,13,15,19-21H,9-12,27H2,1-2H3,(H,28,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301183
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-{3- methyl-3H-[1,2,...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1-c1cnc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H24N10/c1-26-21-19(16-11-18-22(27-13-16)32(2)31-30-18)20(15-5-3-14(12-24)4-6-15)28-23(29-21)33-9-7-17(25)8-10-33/h3-6,11,13,17H,7-10,25H2,1-2H3,(H,26,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301185
PNG
(4-{2-[(3R,4S)-amino-3-fluoropiperidin-1-yl]-5-(2-m...)
Show SMILES CNc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc2nn(C)cc2c1)N1CC[C@H](N)[C@H](F)C1
Show InChI InChI=1S/C25H25FN8/c1-29-24-22(17-7-8-21-18(11-17)13-33(2)32-21)23(16-5-3-15(12-27)4-6-16)30-25(31-24)34-10-9-20(28)19(26)14-34/h3-8,11,13,19-20H,9-10,14,28H2,1-2H3,(H,29,30,31)/t19-,20+/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301017
PNG
(4-[5-(4-methylphenyl)-1-[[(2R)- morpholin-2-yl]met...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(C[C@H]3CNCCO3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N4O/c1-18-2-6-21(7-3-18)26-23(20-8-4-19(15-27)5-9-20)14-25-24(29-26)10-12-30(25)17-22-16-28-11-13-31-22/h2-10,12,14,22,28H,11,13,16-17H2,1H3/t22-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301026
PNG
(4-[5-(4-chlorophenyl)-2-{[(3S)- pyrrolidin-3- ylme...)
Show SMILES Clc1ccc(cc1)-c1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20ClN5/c23-19-7-5-17(6-8-19)20-14-27-22(26-13-16-9-10-25-12-16)28-21(20)18-3-1-15(11-24)2-4-18/h1-8,14,16,25H,9-10,12-13H2,(H,26,27,28)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301029
PNG
(4-[5-(4-methylphenyl)-2-{octahydro- 1H-pyrrolo[3,4...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2CNCC2C1
Show InChI InChI=1S/C25H25N5/c1-17-2-6-19(7-3-17)23-15-28-25(30-11-10-21-13-27-14-22(21)16-30)29-24(23)20-8-4-18(12-26)5-9-20/h2-9,15,21-22,27H,10-11,13-14,16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301053
PNG
(4-[5-(4-methylphenyl)-3-(piperidin-4- ylmethylamin...)
Show SMILES Cc1ccc(cc1)-c1cc(NCC2CCNCC2)nn1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N5/c1-17-2-6-20(7-3-17)22-14-23(26-16-19-10-12-25-13-11-19)27-28(22)21-8-4-18(15-24)5-9-21/h2-9,14,19,25H,10-13,16H2,1H3,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301059
PNG
(4-{1-[((3R)pyrrolidin-3-yl)methyl]-5- (4-methoxyph...)
Show SMILES COc1ccc(cc1)-c1nc2ccn(C[C@@H]3CCNC3)c2cc1-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H23FN4O/c1-32-21-6-4-18(5-7-21)26-22(19-2-3-20(14-28)23(27)12-19)13-25-24(30-26)9-11-31(25)16-17-8-10-29-15-17/h2-7,9,11-13,17,29H,8,10,15-16H2,1H3/t17-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301060
PNG
(4-{1-[((3R)pyrrolidin-3-yl)methyl]-5- (3-fluoro-4-...)
Show SMILES COc1ccc(cc1F)-c1nc2ccn(C[C@@H]3CCNC3)c2cc1-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H22F2N4O/c1-33-25-5-4-18(11-22(25)28)26-20(17-2-3-19(13-29)21(27)10-17)12-24-23(31-26)7-9-32(24)15-16-6-8-30-14-16/h2-5,7,9-12,16,30H,6,8,14-15H2,1H3/t16-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301064
PNG
(4-{3-[((3R)-3-aminopiperidyl) carbonyl]-5-(3-pyrid...)
Show SMILES N[C@@H]1CCCN(C1)C(=O)c1cc(OCc2cccnc2)n(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H22N6O2/c23-12-16-5-7-19(8-6-16)28-21(30-15-17-3-1-9-25-13-17)11-20(26-28)22(29)27-10-2-4-18(24)14-27/h1,3,5-9,11,13,18H,2,4,10,14-15,24H2/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301071
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylpyrazolo[...)
Show SMILES Cn1ncc2cc(cnc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-22-18(13-28-30)10-17(12-26-22)20-14-27-23(31-8-6-19(25)7-9-31)29-21(20)16-4-2-15(11-24)3-5-16/h2-5,10,12-14,19H,6-9,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301081
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methoxypyrimidi...)
Show SMILES COc1ncc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C21H21N7O/c1-29-21-25-11-16(12-26-21)18-13-24-20(28-8-6-17(23)7-9-28)27-19(18)15-4-2-14(10-22)3-5-15/h2-5,11-13,17H,6-9,23H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301086
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[1- (difluoromethyl...)
Show SMILES NC1CCN(CC1)c1ncc(-c2ccc3n(cnc3c2)C(F)F)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H21F2N7/c25-23(26)33-14-30-20-11-17(5-6-21(20)33)19-13-29-24(32-9-7-18(28)8-10-32)31-22(19)16-3-1-15(12-27)2-4-16/h1-6,11,13-14,18,23H,7-10,28H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301087
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[1- (2,2,2-trifluor...)
Show SMILES NC1CCN(CC1)c1ncc(-c2cnn(CC(F)(F)F)c2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C21H19F4N7/c22-18-7-13(1-2-14(18)8-26)19-17(15-9-29-32(11-15)12-21(23,24)25)10-28-20(30-19)31-5-3-16(27)4-6-31/h1-2,7,9-11,16H,3-6,12,27H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301098
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3H- benzimidazol-5...)
Show SMILES NC1CCN(CC1)c1ncc(-c2ccc3nc[nH]c3c2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H21N7/c24-12-15-1-3-16(4-2-15)22-19(17-5-6-20-21(11-17)28-14-27-20)13-26-23(29-22)30-9-7-18(25)8-10-30/h1-6,11,13-14,18H,7-10,25H2,(H,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301100
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1,3- dimethylindaz...)
Show SMILES Cc1nn(C)c2ccc(cc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H24FN7/c1-15-20-11-16(5-6-23(20)32(2)31-15)21-14-29-25(33-9-7-19(28)8-10-33)30-24(21)17-3-4-18(13-27)22(26)12-17/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301103
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylbenzotria...)
Show SMILES Cn1nnc2cc(ccc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H21FN8/c1-31-21-5-4-14(11-20(21)29-30-31)18-13-27-23(32-8-6-17(26)7-9-32)28-22(18)15-2-3-16(12-25)19(24)10-15/h2-5,10-11,13,17H,6-9,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301120
PNG
(4-[2-(2,7-diazaspiro[3.5]nonan-7-yl)-5- (4-methylp...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2(CNC2)CC1
Show InChI InChI=1S/C25H25N5/c1-18-2-6-20(7-3-18)22-15-28-24(30-12-10-25(11-13-30)16-27-17-25)29-23(22)21-8-4-19(14-26)5-9-21/h2-9,15,27H,10-13,16-17H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301125
PNG
(4-[2-(2,3,3a,4,5,7,8,8a-octahydro-1H- pyrrolo[3,4-...)
Show SMILES Cc1nn(C)cc1-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2CNCC2CC1
Show InChI InChI=1S/C24H27N7/c1-16-22(15-30(2)29-16)21-14-27-24(28-23(21)18-5-3-17(11-25)4-6-18)31-9-7-19-12-26-13-20(19)8-10-31/h3-6,14-15,19-20,26H,7-10,12-13H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301148
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2- (cyclopropylami...)
Show SMILES NC1CCN(CC1)c1ncc(-c2cnc(NC3CC3)nc2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H23FN8/c24-20-9-14(1-2-15(20)10-25)21-19(16-11-27-22(28-12-16)30-18-3-4-18)13-29-23(31-21)32-7-5-17(26)6-8-32/h1-2,9,11-13,17-18H,3-8,26H2,(H,27,28,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301152
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylpyrazolo[...)
Show SMILES Cn1ncc2cc(cnc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H21FN8/c1-31-22-17(12-29-31)8-16(11-27-22)19-13-28-23(32-6-4-18(26)5-7-32)30-21(19)14-2-3-15(10-25)20(24)9-14/h2-3,8-9,11-13,18H,4-7,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301154
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-(2-methy...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2nn(C)cc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H24FN7O/c1-32-14-18-11-15(5-6-21(18)31-32)22-23(16-3-4-17(13-27)20(26)12-16)29-25(30-24(22)34-2)33-9-7-19(28)8-10-33/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301156
PNG
(4-[2-(4-aminoazepan-1-yl)-6-methoxy- 5-(2-methyl-2...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2nn(C)cc2c1)N1CCCC(N)CC1
Show InChI InChI=1S/C26H26FN7O/c1-33-15-19-12-16(7-8-22(19)32-33)23-24(17-5-6-18(14-28)21(27)13-17)30-26(31-25(23)35-2)34-10-3-4-20(29)9-11-34/h5-8,12-13,15,20H,3-4,9-11,29H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301178
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-{3- methyl-3H-[1,2,...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1cnc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H23FN10/c1-27-21-19(15-10-18-22(28-12-15)33(2)32-31-18)20(13-3-4-14(11-25)17(24)9-13)29-23(30-21)34-7-5-16(26)6-8-34/h3-4,9-10,12,16H,5-8,26H2,1-2H3,(H,27,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301056
PNG
(4-{1-[((3R)pyrrolidin-3-yl)methyl]-5- (4-methoxyph...)
Show SMILES COc1ccc(cc1)-c1nc2ccn(C[C@@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N4O/c1-31-22-8-6-21(7-9-22)26-23(20-4-2-18(15-27)3-5-20)14-25-24(29-26)11-13-30(25)17-19-10-12-28-16-19/h2-9,11,13-14,19,28H,10,12,16-17H2,1H3/t19-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301057
PNG
(4-{1-[((3R)pyrrolidin-3-yl)methyl]-5- (3-fluoro-4-...)
Show SMILES COc1ccc(cc1F)-c1nc2ccn(C[C@@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H23FN4O/c1-32-25-7-6-20(12-22(25)27)26-21(19-4-2-17(14-28)3-5-19)13-24-23(30-26)9-11-31(24)16-18-8-10-29-15-18/h2-7,9,11-13,18,29H,8,10,15-16H2,1H3/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301068
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[1- (2,2,2-trifluor...)
Show SMILES NC1CCN(CC1)c1ncc(-c2cnn(CC(F)(F)F)c2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H20F3N7/c22-21(23,24)13-31-12-16(10-28-31)18-11-27-20(30-7-5-17(26)6-8-30)29-19(18)15-3-1-14(9-25)2-4-15/h1-4,10-12,17H,5-8,13,26H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301080
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylpyrazolo[...)
Show SMILES Cn1cc2cc(ncc2n1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C23H22N8/c1-30-14-17-10-20(26-13-21(17)29-30)19-12-27-23(31-8-6-18(25)7-9-31)28-22(19)16-4-2-15(11-24)3-5-16/h2-5,10,12-14,18H,6-9,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301082
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1,2- dimethylbenzi...)
Show SMILES Cc1nc2cc(ccc2n1C)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C25H25N7/c1-16-29-22-13-19(7-8-23(22)31(16)2)21-15-28-25(32-11-9-20(27)10-12-32)30-24(21)18-5-3-17(14-26)4-6-18/h3-8,13,15,20H,9-12,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301106
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- methylpyrazo...)
Show SMILES Cn1ccc(n1)C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H20FN7/c1-29-9-8-19(28-29)5-4-17-14-26-22(30-10-6-18(25)7-11-30)27-21(17)15-2-3-16(13-24)20(23)12-15/h2-3,8-9,12,14,18H,6-7,10-11,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301107
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- methyltriazo...)
Show SMILES Cn1cc(nn1)C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C21H19FN8/c1-29-13-18(27-28-29)5-4-16-12-25-21(30-8-6-17(24)7-9-30)26-20(16)14-2-3-15(11-23)19(22)10-14/h2-3,10,12-13,17H,6-9,24H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301109
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- methylpyrazo...)
Show SMILES Cn1cc(cn1)C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H20FN7/c1-29-14-15(12-27-29)2-3-18-13-26-22(30-8-6-19(25)7-9-30)28-21(18)16-4-5-17(11-24)20(23)10-16/h4-5,10,12-14,19H,6-9,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301110
PNG
(4-[2-(4-amino-3-hydroxypiperidin-1- yl)-5-[1-(2,2,...)
Show SMILES NC1CCN(CC1O)c1ncc(-c2cnn(CC(F)(F)F)c2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C21H19F4N7O/c22-16-5-12(1-2-13(16)6-26)19-15(14-7-29-32(9-14)11-21(23,24)25)8-28-20(30-19)31-4-3-17(27)18(33)10-31/h1-2,5,7-9,17-18,33H,3-4,10-11,27H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301116
PNG
(2-fluoro-4-[5-(2-methylindazol-5-yl)- 2-piperazin-...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCNCC1
Show InChI InChI=1S/C23H20FN7/c1-30-14-18-10-15(4-5-21(18)29-30)19-13-27-23(31-8-6-26-7-9-31)28-22(19)16-2-3-17(12-25)20(24)11-16/h2-5,10-11,13-14,26H,6-9H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301118
PNG
(4-[2-(4-amino-3-fluoropiperidin-1-yl)- 5-(1-methyl...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)C(F)C1
Show InChI InChI=1S/C24H21F2N7/c1-32-22-5-4-14(8-17(22)11-30-32)18-12-29-24(33-7-6-21(28)20(26)13-33)31-23(18)15-2-3-16(10-27)19(25)9-15/h2-5,8-9,11-12,20-21H,6-7,13,28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301138
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[6- (2,2,2-trifluor...)
Show SMILES NC1CCN(CC1)c1ncc(-c2ccc(OCC(F)(F)F)nc2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H21F3N6O/c24-23(25,26)14-33-20-6-5-17(12-29-20)19-13-30-22(32-9-7-18(28)8-10-32)31-21(19)16-3-1-15(11-27)2-4-16/h1-6,12-13,18H,7-10,14,28H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301157
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-(2-methy...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2cn(C)nc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H24FN7O/c1-32-14-18-6-3-15(12-21(18)31-32)22-23(16-4-5-17(13-27)20(26)11-16)29-25(30-24(22)34-2)33-9-7-19(28)8-10-33/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301163
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2- (dimethylamino)...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1cnc(nc1)N(C)C)N1CCC(N)CC1
Show InChI InChI=1S/C23H26N8O/c1-30(2)22-26-13-17(14-27-22)19-20(16-6-4-15(12-24)5-7-16)28-23(29-21(19)32-3)31-10-8-18(25)9-11-31/h4-7,13-14,18H,8-11,25H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301164
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-{3-methy...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1cnc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H22FN9O/c1-32-21-18(30-31-32)10-15(12-27-21)19-20(13-3-4-14(11-25)17(24)9-13)28-23(29-22(19)34-2)33-7-5-16(26)6-8-33/h3-4,9-10,12,16H,5-8,26H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301165
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-{3-methy...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1cnc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H23N9O/c1-31-21-18(29-30-31)11-16(13-26-21)19-20(15-5-3-14(12-24)4-6-15)27-23(28-22(19)33-2)32-9-7-17(25)8-10-32/h3-6,11,13,17H,7-10,25H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301172
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methyl-1H-1,2,3...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H24FN9/c1-28-23-21(14-5-6-20-19(12-14)31-32-33(20)2)22(15-3-4-16(13-26)18(25)11-15)29-24(30-23)34-9-7-17(27)8-10-34/h3-6,11-12,17H,7-10,27H2,1-2H3,(H,28,29,30)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301034
PNG
(4-(2-{[(3aR,5S,6aS)- octahydrocyclopenta[c]pyrrol-...)
Show SMILES Cc1ccc(cc1)-c1cnc(N[C@H]2C[C@@H]3CNC[C@@H]3C2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H25N5/c1-16-2-6-18(7-3-16)23-15-28-25(29-22-10-20-13-27-14-21(20)11-22)30-24(23)19-8-4-17(12-26)5-9-19/h2-9,15,20-22,27H,10-11,13-14H2,1H3,(H,28,29,30)/t20-,21+,22+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301055
PNG
(4-[5-(4-methylphenyl)-1-piperidin-4- ylpyrazolo[4,...)
Show SMILES Cc1ccc(cc1)-c1nc2cnn(C3CCNCC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5/c1-17-2-6-20(7-3-17)25-22(19-8-4-18(15-26)5-9-19)14-24-23(29-25)16-28-30(24)21-10-12-27-13-11-21/h2-9,14,16,21,27H,10-13H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301095
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylpyrazolo[...)
Show SMILES Cn1ncc2nc(ncc12)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C22H21N9/c1-30-19-13-25-21(28-18(19)12-27-30)17-11-26-22(31-8-6-16(24)7-9-31)29-20(17)15-4-2-14(10-23)3-5-15/h2-5,11-13,16H,6-9,24H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301088
PNG
(4-[2-(4-aminopiperidin-1-yl)-5- ([1,2,4]triazolo[1...)
Show SMILES NC1CCN(CC1)c1ncc(-c2ccn3ncnc3c2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20N8/c23-12-15-1-3-16(4-2-15)21-19(17-5-10-30-20(11-17)26-14-27-30)13-25-22(28-21)29-8-6-18(24)7-9-29/h1-5,10-11,13-14,18H,6-9,24H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301009
PNG
(4-[5-chloro-1-[[(3R)-pyrrolidin-3- yl]methyl]pyrro...)
Show SMILES Clc1nc2ccn(C[C@@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H17ClN4/c20-19-16(15-3-1-13(10-21)2-4-15)9-18-17(23-19)6-8-24(18)12-14-5-7-22-11-14/h1-4,6,8-9,14,22H,5,7,11-12H2/t14-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301015
PNG
(4-[1-[(3-fluoropyrrolidin-3-yl)methyl]- 5-morpholi...)
Show SMILES FC1(Cn2ccc3nc(N4CCOCC4)c(cc23)-c2ccc(cc2)C#N)CCNC1
Show InChI InChI=1S/C23H24FN5O/c24-23(6-7-26-15-23)16-29-8-5-20-21(29)13-19(18-3-1-17(14-25)2-4-18)22(27-20)28-9-11-30-12-10-28/h1-5,8,13,26H,6-7,9-12,15-16H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301024
PNG
(4-(5-chloro-2-{[(3S)-pyrrolidin-3- ylmethyl]amino}...)
Show SMILES Clc1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C16H16ClN5/c17-14-10-21-16(20-9-12-5-6-19-8-12)22-15(14)13-3-1-11(7-18)2-4-13/h1-4,10,12,19H,5-6,8-9H2,(H,20,21,22)/t12-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301013
PNG
(4-[5-morpholin-4-yl-1-[[(3R)- pyrrolidin-3-yl]meth...)
Show SMILES N#Cc1ccc(cc1)-c1cc2n(C[C@@H]3CCNC3)ccc2nc1N1CCOCC1
Show InChI InChI=1S/C23H25N5O/c24-14-17-1-3-19(4-2-17)20-13-22-21(26-23(20)27-9-11-29-12-10-27)6-8-28(22)16-18-5-7-25-15-18/h1-4,6,8,13,18,25H,5,7,9-12,15-16H2/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301048
PNG
(4-[5-(4-methylphenyl)-2-{9-oxa-3,7- diazabicyclo[3...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC2CNCC(C1)O2
Show InChI InChI=1S/C24H23N5O/c1-16-2-6-18(7-3-16)22-13-27-24(29-14-20-11-26-12-21(15-29)30-20)28-23(22)19-8-4-17(10-25)5-9-19/h2-9,13,20-21,26H,11-12,14-15H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301049
PNG
(4-[5-(4-fluorophenyl)-2-{9-oxa-3,7- diazabicyclo[3...)
Show SMILES Fc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC2CNCC(C1)O2
Show InChI InChI=1S/C23H20FN5O/c24-18-7-5-16(6-8-18)21-12-27-23(29-13-19-10-26-11-20(14-29)30-19)28-22(21)17-3-1-15(9-25)2-4-17/h1-8,12,19-20,26H,10-11,13-14H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301041
PNG
((+-)-4-[5-(4-fluorophenyl)-2- [(morpholin-2- ylmet...)
Show SMILES Fc1ccc(cc1)-c1cnc(NCC2CNCCO2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20FN5O/c23-18-7-5-16(6-8-18)20-14-27-22(26-13-19-12-25-9-10-29-19)28-21(20)17-3-1-15(11-24)2-4-17/h1-8,14,19,25H,9-10,12-13H2,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301093
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylpyrazolo[...)
Show SMILES Cn1cc2nc(ncc2n1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C22H21N9/c1-30-13-19-18(29-30)12-25-21(27-19)17-11-26-22(31-8-6-16(24)7-9-31)28-20(17)15-4-2-14(10-23)3-5-15/h2-5,11-13,16H,6-9,24H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301011
PNG
(4-[5-chloro-1-[[(3S)-pyrrolidin-3- yl]methyl]pyrro...)
Show SMILES Clc1nc2ccn(C[C@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H17ClN4/c20-19-16(15-3-1-13(10-21)2-4-15)9-18-17(23-19)6-8-24(18)12-14-5-7-22-11-14/h1-4,6,8-9,14,22H,5,7,11-12H2/t14-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301134
PNG
(4-[2-(4-aminopiperidin-1-yl)-5- ([1,2,4]triazolo[1...)
Show SMILES NC1CCN(CC1)c1ncc(-c2ccc3ncnn3c2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20N8/c23-11-15-1-3-16(4-2-15)21-19(17-5-6-20-26-14-27-30(20)13-17)12-25-22(28-21)29-9-7-18(24)8-10-29/h1-6,12-14,18H,7-10,24H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%