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Patent code US10131667

Compile Data Set for Download or QSAR

Found 699 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301283
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1,3,4,7-tetra...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3NC2=O)c1F
Show InChI InChI=1S/C16H13F2N5O3/c1-25-9-3-10(26-2)12(18)14(11(9)17)23-6-7-4-19-15-8(5-20-22-15)13(7)21-16(23)24/h3-5H,6H2,1-2H3,(H,21,24)(H,19,20,22)
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Incyte Corporation

US Patent




US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301293
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-pyridazin-3...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C2=O)c2cccnn2)c1F
Show InChI InChI=1S/C21H16F2N6O3/c1-31-13-8-14(32-2)17(23)19(16(13)22)28-10-11-9-25-20-12(5-7-24-20)18(11)29(21(28)30)15-4-3-6-26-27-15/h3-9H,10H2,1-2H3,(H,24,25)
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US Patent




US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301294
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-(m...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H25F2N5O4/c1-28-20-13(10-26-22-15(20)8-14(27-22)12-29-4-6-34-7-5-29)11-30(23(28)31)21-18(24)16(32-2)9-17(33-3)19(21)25/h8-10H,4-7,11-12H2,1-3H3,(H,26,27)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301297
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(3,3-diflu...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCCC(F)(F)C5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H25F4N5O3/c1-31-20-13(10-33(23(31)34)21-18(25)16(35-2)8-17(36-3)19(21)26)9-29-22-15(20)7-14(30-22)11-32-6-4-5-24(27,28)12-32/h7-9H,4-6,10-12H2,1-3H3,(H,29,30)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301298
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-(2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCOCC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H27F2N5O4/c1-29-21-14(12-27-23-16(21)10-15(28-23)4-5-30-6-8-35-9-7-30)13-31(24(29)32)22-19(25)17(33-2)11-18(34-3)20(22)26/h10-12H,4-9,13H2,1-3H3,(H,27,28)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301300
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-(2...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCCC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H27F2N5O3/c1-29-21-14(12-27-23-16(21)10-15(28-23)6-9-30-7-4-5-8-30)13-31(24(29)32)22-19(25)17(33-2)11-18(34-3)20(22)26/h10-12H,4-9,13H2,1-3H3,(H,27,28)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301304
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-{[(3R,5S)-3...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(cc4c3N(C)C2=O)C(=O)N2C[C@H](C)N[C@H](C)C2)c1F
Show InChI InChI=1S/C25H28F2N6O4/c1-12-9-32(10-13(2)29-12)24(34)16-6-15-21-14(8-28-23(15)30-16)11-33(25(35)31(21)3)22-19(26)17(36-4)7-18(37-5)20(22)27/h6-8,12-13,29H,9-11H2,1-5H3,(H,28,30)/t12-,13+
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301312
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-[(4...)
Show SMILES CCN1CCN(Cc2cc3c4N(CC)C(=O)N(Cc4cnc3[nH]2)c2c(F)c(OC)cc(OC)c2F)CC1
Show InChI InChI=1S/C26H32F2N6O3/c1-5-31-7-9-32(10-8-31)15-17-11-18-23-16(13-29-25(18)30-17)14-34(26(35)33(23)6-2)24-21(27)19(36-3)12-20(37-4)22(24)28/h11-13H,5-10,14-15H2,1-4H3,(H,29,30)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301313
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-[(...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCN(C)CC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H28F2N6O3/c1-29-5-7-31(8-6-29)13-15-9-16-21-14(11-27-23(16)28-15)12-32(24(33)30(21)2)22-19(25)17(34-3)10-18(35-4)20(22)26/h9-11H,5-8,12-13H2,1-4H3,(H,27,28)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301316
PNG
(1-{[3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCC(CC5)C#N)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C25H26F2N6O3/c1-31-22-15(12-33(25(31)34)23-20(26)18(35-2)9-19(36-3)21(23)27)11-29-24-17(22)8-16(30-24)13-32-6-4-14(10-28)5-7-32/h8-9,11,14H,4-7,12-13H2,1-3H3,(H,29,30)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301319
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-{[...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN[C@H]5CCOC5)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H25F2N5O4/c1-29-20-12(8-27-22-15(20)6-14(28-22)9-26-13-4-5-34-11-13)10-30(23(29)31)21-18(24)16(32-2)7-17(33-3)19(21)25/h6-8,13,26H,4-5,9-11H2,1-3H3,(H,27,28)/t13-/m0/s1
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301330
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCOCC5)cc4c3N(CCO)C2=O)c1F
Show InChI InChI=1S/C25H29F2N5O5/c1-35-18-12-19(36-2)21(27)23(20(18)26)32-14-15-13-28-24-17(22(15)31(5-8-33)25(32)34)11-16(29-24)3-4-30-6-9-37-10-7-30/h11-13,33H,3-10,14H2,1-2H3,(H,28,29)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301332
PNG
(7'-(2,6-difluoro-3,5-dimethoxyphenyl)-6',7'-dihydr...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3C3(CCC3)C2=O)c1F
Show InChI InChI=1S/C21H19F2N3O3/c1-28-13-8-14(29-2)17(23)18(16(13)22)26-10-11-9-25-19-12(4-7-24-19)15(11)21(20(26)27)5-3-6-21/h4,7-9H,3,5-6,10H2,1-2H3,(H,24,25)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301334
PNG
(7'-(2,6-difluoro-3,5-dimethoxyphenyl)-2,3,5,6,6',7...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3C3(CCOCC3)C2=O)c1F
Show InChI InChI=1S/C22H21F2N3O4/c1-29-14-9-15(30-2)18(24)19(17(14)23)27-11-12-10-26-20-13(3-6-25-20)16(12)22(21(27)28)4-7-31-8-5-22/h3,6,9-10H,4-5,7-8,11H2,1-2H3,(H,25,26)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301335
PNG
(7'-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-6',...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3C3(CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O3/c1-28-8-5-23(6-9-28)17-13(11-27-21-14(17)4-7-26-21)12-29(22(23)30)20-18(24)15(31-2)10-16(32-3)19(20)25/h4,7,10-11H,5-6,8-9,12H2,1-3H3,(H,26,27)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301335
PNG
(7'-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-6',...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3C3(CCN(C)CC3)C2=O)c1F
Show InChI InChI=1S/C23H24F2N4O3/c1-28-8-5-23(6-9-28)17-13(11-27-21-14(17)4-7-26-21)12-29(22(23)30)20-18(24)15(31-2)10-16(32-3)19(20)25/h4,7,10-11H,5-6,8-9,12H2,1-3H3,(H,26,27)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301343
PNG
(7-(2,6-difluoro-3,5-dimethoxyphenyl)-2-[2-(4-ethyl...)
Show SMILES CCN1CCN(CCc2cc3c4c(CN(C(=O)C4(C)C)c4c(F)c(OC)cc(OC)c4F)cnc3[nH]2)CC1
Show InChI InChI=1S/C28H35F2N5O3/c1-6-33-9-11-34(12-10-33)8-7-18-13-19-22-17(15-31-26(19)32-18)16-35(27(36)28(22,2)3)25-23(29)20(37-4)14-21(38-5)24(25)30/h13-15H,6-12,16H2,1-5H3,(H,31,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301345
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(1,3-oxazol...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(Cc3cocn3)C2=O)c1F
Show InChI InChI=1S/C20H16F2N6O4/c1-30-13-3-14(31-2)16(22)18(15(13)21)27-6-10-4-23-19-12(5-25-26-19)17(10)28(20(27)29)7-11-8-32-9-24-11/h3-5,8-9H,6-7H2,1-2H3,(H,23,25,26)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301351
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-[(2S)-tetra...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(C[C@@H]3CCCO3)C2=O)c1F
Show InChI InChI=1S/C21H21F2N5O4/c1-30-14-6-15(31-2)17(23)19(16(14)22)27-9-11-7-24-20-13(8-25-26-20)18(11)28(21(27)29)10-12-4-3-5-32-12/h6-8,12H,3-5,9-10H2,1-2H3,(H,24,25,26)/t12-/m0/s1
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301355
PNG
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-pyridin-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(CCc3ccncc3)C2=O)c1F
Show InChI InChI=1S/C23H20F2N6O3/c1-33-16-9-17(34-2)19(25)21(18(16)24)31-12-14-10-27-22-15(11-28-29-22)20(14)30(23(31)32)8-5-13-3-6-26-7-4-13/h3-4,6-7,9-11H,5,8,12H2,1-2H3,(H,27,28,29)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301356
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(1-ethyl-1H...)
Show SMILES CCn1cc(cn1)N1C(=O)N(Cc2cnc3[nH]ncc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C21H19F2N7O3/c1-4-28-10-12(7-26-28)30-18-11(6-24-20-13(18)8-25-27-20)9-29(21(30)31)19-16(22)14(32-2)5-15(33-3)17(19)23/h5-8,10H,4,9H2,1-3H3,(H,24,25,27)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301364
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluoroph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C28H26F3N5O4/c1-38-21-12-22(39-2)24(31)26(23(21)30)35-14-16-13-32-27-18(11-17(33-27)15-34-7-9-40-10-8-34)25(16)36(28(35)37)20-6-4-3-5-19(20)29/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,32,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301364
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-fluoroph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3N(C2=O)c2ccccc2F)c1F
Show InChI InChI=1S/C28H26F3N5O4/c1-38-21-12-22(39-2)24(31)26(23(21)30)35-14-16-13-32-27-18(11-17(33-27)15-34-7-9-40-10-8-34)25(16)36(28(35)37)20-6-4-3-5-19(20)29/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,32,33)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301365
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(4-ethylpi...)
Show SMILES CCN1CCN(Cc2cc3c4N(C(=O)N(Cc4cnc3[nH]2)c2c(F)c(OC)cc(OC)c2F)c2ccccc2F)CC1
Show InChI InChI=1S/C30H31F3N6O3/c1-4-36-9-11-37(12-10-36)17-19-13-20-27-18(15-34-29(20)35-19)16-38(30(40)39(27)22-8-6-5-7-21(22)31)28-25(32)23(41-2)14-24(42-3)26(28)33/h5-8,13-15H,4,9-12,16-17H2,1-3H3,(H,34,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301365
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(4-ethylpi...)
Show SMILES CCN1CCN(Cc2cc3c4N(C(=O)N(Cc4cnc3[nH]2)c2c(F)c(OC)cc(OC)c2F)c2ccccc2F)CC1
Show InChI InChI=1S/C30H31F3N6O3/c1-4-36-9-11-37(12-10-36)17-19-13-20-27-18(15-34-29(20)35-19)16-38(30(40)39(27)22-8-6-5-7-21(22)31)28-25(32)23(41-2)14-24(42-3)26(28)33/h5-8,13-15H,4,9-12,16-17H2,1-3H3,(H,34,35)
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US Patent




US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301367
PNG
(1-cyclobutyl-3-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCOCC5)cc4c3N(C3CCC3)C2=O)c1F
Show InChI InChI=1S/C27H31F2N5O4/c1-36-20-13-21(37-2)23(29)25(22(20)28)33-15-16-14-30-26-19(24(16)34(27(33)35)18-4-3-5-18)12-17(31-26)6-7-32-8-10-38-11-9-32/h12-14,18H,3-11,15H2,1-2H3,(H,30,31)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301374
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(4-fluoroph...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCN(C)CC5)cc4c3N(C2=O)c2ccc(F)cc2)c1F
Show InChI InChI=1S/C29H29F3N6O3/c1-35-8-10-36(11-9-35)16-19-12-21-26-17(14-33-28(21)34-19)15-37(29(39)38(26)20-6-4-18(30)5-7-20)27-24(31)22(40-2)13-23(41-3)25(27)32/h4-7,12-14H,8-11,15-16H2,1-3H3,(H,33,34)
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US Patent




US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301375
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(4-fluoroph...)
Show SMILES CCN1CCN(Cc2cc3c4N(C(=O)N(Cc4cnc3[nH]2)c2c(F)c(OC)cc(OC)c2F)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C30H31F3N6O3/c1-4-36-9-11-37(12-10-36)17-20-13-22-27-18(15-34-29(22)35-20)16-38(30(40)39(27)21-7-5-19(31)6-8-21)28-25(32)23(41-2)14-24(42-3)26(28)33/h5-8,13-15H,4,9-12,16-17H2,1-3H3,(H,34,35)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301386
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(2-methoxy...)
Show SMILES COc1cc(CN2C(=O)N(Cc3cnc4[nH]c(CN5CCOCC5)cc4c23)c2c(F)c(OC)cc(OC)c2F)ccn1
Show InChI InChI=1S/C29H30F2N6O5/c1-39-21-12-22(40-2)25(31)27(24(21)30)37-15-18-13-33-28-20(11-19(34-28)16-35-6-8-42-9-7-35)26(18)36(29(37)38)14-17-4-5-32-23(10-17)41-3/h4-5,10-13H,6-9,14-16H2,1-3H3,(H,33,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301390
PNG
(7-(2,6-difluoro-3,5-dimethoxyphenyl)-2-[(3-hydroxy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CC(O)C5)cc4c3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C24H26F2N4O4/c1-24(2)18-12(7-27-22-15(18)5-13(28-22)9-29-10-14(31)11-29)8-30(23(24)32)21-19(25)16(33-3)6-17(34-4)20(21)26/h5-7,14,31H,8-11H2,1-4H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301391
PNG
(7-(2,6-difluoro-3,5-dimethoxyphenyl)-2-[(3-fluoroa...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CC(F)C5)cc4c3C(C)(C)C2=O)c1F
Show InChI InChI=1S/C24H25F3N4O3/c1-24(2)18-12(7-28-22-15(18)5-14(29-22)11-30-9-13(25)10-30)8-31(23(24)32)21-19(26)16(33-3)6-17(34-4)20(21)27/h5-7,13H,8-11H2,1-4H3,(H,28,29)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301392
PNG
(1-{[3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CC(C5)C#N)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O3/c1-29-20-13(7-27-22-15(20)4-14(28-22)11-30-8-12(6-26)9-30)10-31(23(29)32)21-18(24)16(33-2)5-17(34-3)19(21)25/h4-5,7,12H,8-11H2,1-3H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301392
PNG
(1-{[3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CC(C5)C#N)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C23H22F2N6O3/c1-29-20-13(7-27-22-15(20)4-14(28-22)11-30-8-12(6-26)9-30)10-31(23(29)32)21-18(24)16(33-2)5-17(34-3)19(21)25/h4-5,7,12H,8-11H2,1-3H3,(H,27,28)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301393
PNG
((3R)-1-{[3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-me...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CC[C@H](C5)C#N)cc4c3N(C)C2=O)c1F
Show InChI InChI=1S/C24H24F2N6O3/c1-30-21-14(9-28-23-16(21)6-15(29-23)12-31-5-4-13(8-27)10-31)11-32(24(30)33)22-19(25)17(34-2)7-18(35-3)20(22)26/h6-7,9,13H,4-5,10-12H2,1-3H3,(H,28,29)/t13-/m0/s1
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301394
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[2-(3-fluor...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CC(F)C5)cc4c3N(CCO)C2=O)c1F
Show InChI InChI=1S/C24H26F3N5O4/c1-35-17-8-18(36-2)20(27)22(19(17)26)32-10-13-9-28-23-16(21(13)31(5-6-33)24(32)34)7-15(29-23)3-4-30-11-14(25)12-30/h7-9,14,33H,3-6,10-12H2,1-2H3,(H,28,29)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301394
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[2-(3-fluor...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CC(F)C5)cc4c3N(CCO)C2=O)c1F
Show InChI InChI=1S/C24H26F3N5O4/c1-35-17-8-18(36-2)20(27)22(19(17)26)32-10-13-9-28-23-16(21(13)31(5-6-33)24(32)34)7-15(29-23)3-4-30-11-14(25)12-30/h7-9,14,33H,3-6,10-12H2,1-2H3,(H,28,29)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301395
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,3-difluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3N(C2=O)c2cccc(F)c2F)c1F
Show InChI InChI=1S/C28H25F4N5O4/c1-39-20-11-21(40-2)24(32)26(23(20)31)36-13-15-12-33-27-17(10-16(34-27)14-35-6-8-41-9-7-35)25(15)37(28(36)38)19-5-3-4-18(29)22(19)30/h3-5,10-12H,6-9,13-14H2,1-2H3,(H,33,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301398
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(3-fluoroph...)
Show SMILES CCN1CCN(Cc2cc3c4N(C(=O)N(Cc4cnc3[nH]2)c2c(F)c(OC)cc(OC)c2F)c2cccc(F)c2)CC1
Show InChI InChI=1S/C30H31F3N6O3/c1-4-36-8-10-37(11-9-36)17-20-13-22-27-18(15-34-29(22)35-20)16-38(30(40)39(27)21-7-5-6-19(31)12-21)28-25(32)23(41-2)14-24(42-3)26(28)33/h5-7,12-15H,4,8-11,16-17H2,1-3H3,(H,34,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301401
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(6-methylp...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(Cc3cccc(C)n3)C2=O)c1F
Show InChI InChI=1S/C23H20F2N6O3/c1-12-5-4-6-14(28-12)11-31-20-13(8-26-22-15(20)9-27-29-22)10-30(23(31)32)21-18(24)16(33-2)7-17(34-3)19(21)25/h4-9H,10-11H2,1-3H3,(H,26,27,29)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301403
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-[(2...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]c(Cn4ccccc4=O)cc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H23F2N5O4/c1-4-31-22-14(11-28-24-16(22)9-15(29-24)13-30-8-6-5-7-19(30)33)12-32(25(31)34)23-20(26)17(35-2)10-18(36-3)21(23)27/h5-11H,4,12-13H2,1-3H3,(H,28,29)
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Incyte Corporation

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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301407
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2,3-difluo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CCN5CCN(C)CC5)cc4c3N(C2=O)c2cccc(F)c2F)c1F
Show InChI InChI=1S/C30H30F4N6O3/c1-37-9-11-38(12-10-37)8-7-18-13-19-27-17(15-35-29(19)36-18)16-39(28-25(33)22(42-2)14-23(43-3)26(28)34)30(41)40(27)21-6-4-5-20(31)24(21)32/h4-6,13-15H,7-12,16H2,1-3H3,(H,35,36)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301023
PNG
(3-(3,5-Dimethoxyphenyl)-1-methyl-1,3,4,7-tetrahydr...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc3[nH]ccc3c2N(C)C1=O
Show InChI InChI=1S/C18H18N4O3/c1-21-16-11(9-20-17-15(16)4-5-19-17)10-22(18(21)23)12-6-13(24-2)8-14(7-12)25-3/h4-9H,10H2,1-3H3,(H,19,20)
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Incyte Corporation

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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301188
PNG
(1-Cyclopropyl-3-(3,5-dimethoxyphenyl)-1,3,4,7-tetr...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc3[nH]ccc3c2N(C2CC2)C1=O
Show InChI InChI=1S/C20H20N4O3/c1-26-15-7-14(8-16(9-15)27-2)23-11-12-10-22-19-17(5-6-21-19)18(12)24(20(23)25)13-3-4-13/h5-10,13H,3-4,11H2,1-2H3,(H,21,22)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301196
PNG
(3-(3,5-Dimethoxyphenyl)-N,1-dimethyl-2-oxo-2,3,4,7...)
Show SMILES CNC(=O)c1cc2c3N(C)C(=O)N(Cc3cnc2[nH]1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C20H21N5O4/c1-21-19(26)16-8-15-17-11(9-22-18(15)23-16)10-25(20(27)24(17)2)12-5-13(28-3)7-14(6-12)29-4/h5-9H,10H2,1-4H3,(H,21,26)(H,22,23)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301196
PNG
(3-(3,5-Dimethoxyphenyl)-N,1-dimethyl-2-oxo-2,3,4,7...)
Show SMILES CNC(=O)c1cc2c3N(C)C(=O)N(Cc3cnc2[nH]1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C20H21N5O4/c1-21-19(26)16-8-15-17-11(9-22-18(15)23-16)10-25(20(27)24(17)2)12-5-13(28-3)7-14(6-12)29-4/h5-9H,10H2,1-4H3,(H,21,26)(H,22,23)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301196
PNG
(3-(3,5-Dimethoxyphenyl)-N,1-dimethyl-2-oxo-2,3,4,7...)
Show SMILES CNC(=O)c1cc2c3N(C)C(=O)N(Cc3cnc2[nH]1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C20H21N5O4/c1-21-19(26)16-8-15-17-11(9-22-18(15)23-16)10-25(20(27)24(17)2)12-5-13(28-3)7-14(6-12)29-4/h5-9H,10H2,1-4H3,(H,21,26)(H,22,23)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301197
PNG
(3-(2-Chloro-3,5-dimethoxyphenyl)-1-methyl-8-(1-met...)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc3[nH]c(cc3c2N(C)C1=O)-c1cnn(C)c1
Show InChI InChI=1S/C22H21ClN6O3/c1-27-10-12(9-25-27)16-7-15-20-13(8-24-21(15)26-16)11-29(22(30)28(20)2)17-5-14(31-3)6-18(32-4)19(17)23/h5-10H,11H2,1-4H3,(H,24,26)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM301198
PNG
(3-(2-Chloro-3,5-dimethoxyphenyl)-8-[1-(2-hydroxyet...)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc3[nH]c(cc3c2N(C)C1=O)-c1cnn(CCO)c1
Show InChI InChI=1S/C23H23ClN6O4/c1-28-21-14(12-30(23(28)32)18-6-15(33-2)7-19(34-3)20(18)24)9-25-22-16(21)8-17(27-22)13-10-26-29(11-13)4-5-31/h6-11,31H,4-5,12H2,1-3H3,(H,25,27)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301198
PNG
(3-(2-Chloro-3,5-dimethoxyphenyl)-8-[1-(2-hydroxyet...)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc3[nH]c(cc3c2N(C)C1=O)-c1cnn(CCO)c1
Show InChI InChI=1S/C23H23ClN6O4/c1-28-21-14(12-30(23(28)32)18-6-15(33-2)7-19(34-3)20(18)24)9-25-22-16(21)8-17(27-22)13-10-26-29(11-13)4-5-31/h6-11,31H,4-5,12H2,1-3H3,(H,25,27)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM301203
PNG
(3-(3,5-Dimethoxyphenyl)-N,N,1-trimethyl-2-oxo-2,3,...)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc3[nH]c(cc3c2N(C)C1=O)C(=O)N(C)C
Show InChI InChI=1S/C21H23N5O4/c1-24(2)20(27)17-9-16-18-12(10-22-19(16)23-17)11-26(21(28)25(18)3)13-6-14(29-4)8-15(7-13)30-5/h6-10H,11H2,1-5H3,(H,22,23)
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US Patent US10131667 (2018)

More data for this
Ligand-Target Pair
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