BindingDB logo
myBDB logout

Patent code US10131675

Compile Data Set for Download or QSAR
Found 153 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301575
PNG
(BDBM301631 | US10131675, Example 61)
Show SMILES CCN(C1CC1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C19H24N8O/c1-4-26(12-5-6-12)15-13-16(27-7-8-28-19(2,3)17(27)23-13)25-14(24-15)11-9-21-18(20)22-10-11/h9-10,12H,4-8H2,1-3H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
0.390n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301624
PNG
(US10131675, Example 110)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cc(Cl)c2c1)N1CC(C1)C#N
Show InChI InChI=1S/C21H19ClN8O/c1-21(2)20-26-15-18(29-9-11(6-23)10-29)27-16(28-19(15)30(20)3-4-31-21)12-5-13-14(22)8-25-17(13)24-7-12/h5,7-8,11H,3-4,9-10H2,1-2H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.25n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301643
PNG
(US10131675, Example 129)
Show SMILES CN(C)c1nc(nc2n3CCCOCc3nc12)-c1cnc2[nH]cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N7O/c1-28(2)17-14-18(29-4-3-5-30-9-13(29)25-14)27-15(26-17)10-6-11-12(19(20,21)22)8-24-16(11)23-7-10/h6-8H,3-5,9H2,1-2H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.64n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301657
PNG
(US10131675, Example 144)
Show SMILES CC1(C)OCCn2c1nc1c(nc(cc21)-c1cnc(N)c(c1)C#N)N1CC2CC1C2
Show InChI InChI=1S/C22H23N7O/c1-22(2)21-27-18-17(28(21)3-4-30-22)8-16(14-7-13(9-23)19(24)25-10-14)26-20(18)29-11-12-5-15(29)6-12/h7-8,10,12,15H,3-6,11H2,1-2H3,(H2,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
2.23n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301518
PNG
(US10131675, Example 3)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C23H25N7O/c1-12-9-24-19-16(12)8-14(10-25-19)18-27-20-17(21(28-18)30-11-13-6-15(30)7-13)26-22-23(2,3)31-5-4-29(20)22/h8-10,13,15H,4-7,11H2,1-3H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
4.92n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301556
PNG
(US10131675, Example 42)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cc(C#N)c2c1)N1CCC2(COC2)C1
Show InChI InChI=1S/C24H24N8O2/c1-23(2)22-28-17-20(31-4-3-24(11-31)12-33-13-24)29-18(30-21(17)32(22)5-6-34-23)14-7-16-15(8-25)10-27-19(16)26-9-14/h7,9-10H,3-6,11-13H2,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
4.97n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301635
PNG
(US10131675, Example 121)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(C2CC2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C21H22N6O/c1-11-9-22-18-14(11)8-13(10-23-18)17-24-15(12-4-5-12)16-19(26-17)27-6-7-28-21(2,3)20(27)25-16/h8-10,12H,4-7H2,1-3H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.48n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301554
PNG
(US10131675, Example 40)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cc(Cl)c2c1)N1CC(O)C1
Show InChI InChI=1S/C20H20ClN7O2/c1-20(2)19-24-14-17(27-8-11(29)9-27)25-15(26-18(14)28(19)3-4-30-20)10-5-12-13(21)7-23-16(12)22-6-10/h5-7,11,29H,3-4,8-9H2,1-2H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.91n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301604
PNG
(US10131675, Example 90)
Show SMILES CC1(C)OCCn2c1nc1c(nc(cc21)-c1cnc(N)c(c1)C(F)(F)F)N1CC2CC1C2
Show InChI InChI=1S/C22H23F3N6O/c1-21(2)20-29-17-16(30(20)3-4-32-21)8-15(28-19(17)31-10-11-5-13(31)6-11)12-7-14(22(23,24)25)18(26)27-9-12/h7-9,11,13H,3-6,10H2,1-2H3,(H2,26,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.98n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301658
PNG
(US10131675, Example 145)
Show SMILES COC1CN(C1)c1nc(nc2n3CCCOCc3nc12)-c1cnc2[nH]cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N7O2/c1-32-12-8-30(9-12)19-16-20(31-3-2-4-33-10-15(31)27-16)29-17(28-19)11-5-13-14(21(22,23)24)7-26-18(13)25-6-11/h5-7,12H,2-4,8-10H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
6.49n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301553
PNG
(US10131675, Example 39)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cc(c2c1)C(F)(F)F)N1CC(O)C1
Show InChI InChI=1S/C21H20F3N7O2/c1-20(2)19-27-14-17(30-8-11(32)9-30)28-15(29-18(14)31(19)3-4-33-20)10-5-12-13(21(22,23)24)7-26-16(12)25-6-10/h5-7,11,32H,3-4,8-9H2,1-2H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
6.79n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301519
PNG
(US10131675, Example 4)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CC(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C21H22FN7O/c1-11-7-23-17-14(11)6-12(8-24-17)16-26-18(28-9-13(22)10-28)15-19(27-16)29-4-5-30-21(2,3)20(29)25-15/h6-8,13H,4-5,9-10H2,1-3H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
9.74n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301559
PNG
(US10131675, Example 45)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cc(c2c1)C(F)(F)F)N1CC(F)C1
Show InChI InChI=1S/C21H19F4N7O/c1-20(2)19-28-14-17(31-8-11(22)9-31)29-15(30-18(14)32(19)3-4-33-20)10-5-12-13(21(23,24)25)7-27-16(12)26-6-10/h5-7,11H,3-4,8-9H2,1-2H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
9.87n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301544
PNG
(US10131675, Example 30)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CCC3(COC3)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C24H27N7O2/c1-14-9-25-19-16(14)8-15(10-26-19)18-28-20(30-5-4-24(11-30)12-32-13-24)17-21(29-18)31-6-7-33-23(2,3)22(31)27-17/h8-10H,4-7,11-13H2,1-3H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
10.2n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301580
PNG
(US10131675, Example 66)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C21H21F2N7O/c1-11-7-24-16-13(11)6-12(8-25-16)15-27-17(29-9-21(22,23)10-29)14-18(28-15)30-4-5-31-20(2,3)19(30)26-14/h6-8H,4-5,9-10H2,1-3H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
11.9n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301546
PNG
(US10131675, Example 32)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CC(O)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C21H23N7O2/c1-11-7-22-17-14(11)6-12(8-23-17)16-25-18(27-9-13(29)10-27)15-19(26-16)28-4-5-30-21(2,3)20(28)24-15/h6-8,13,29H,4-5,9-10H2,1-3H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
13.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301601
PNG
(US10131675, Example 87)
Show SMILES COc1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc2[nH]cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N6O2/c1-18(2)17-25-12-15(28(17)4-5-30-18)26-13(27-16(12)29-3)9-6-10-11(19(20,21)22)8-24-14(10)23-7-9/h6-8H,4-5H2,1-3H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
14n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301642
PNG
(US10131675, Example 128)
Show SMILES CN(C)c1nc(nc2n3CCCOCc3nc12)-c1cnc2[nH]cc(C#N)c2c1
Show InChI InChI=1S/C19H18N8O/c1-26(2)18-15-19(27-4-3-5-28-10-14(27)23-15)25-16(24-18)11-6-13-12(7-20)9-22-17(13)21-8-11/h6,8-9H,3-5,10H2,1-2H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
17.9n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301630
PNG
(US10131675, Example 116)
Show SMILES CC1(C)OCCn2c1nc1c(nc(cc21)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C20H23N7O/c1-20(2)18-25-16-15(26(18)3-4-28-20)7-14(12-8-22-19(21)23-9-12)24-17(16)27-10-11-5-13(27)6-11/h7-9,11,13H,3-6,10H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
21.3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301588
PNG
(US10131675, Example 74)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CCC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C22H23F2N7O/c1-12-9-25-17-14(12)8-13(10-26-17)16-28-18(30-5-4-22(23,24)11-30)15-19(29-16)31-6-7-32-21(2,3)20(31)27-15/h8-10H,4-7,11H2,1-3H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
25.9n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301555
PNG
(US10131675, Example 41)
Show SMILES COC1CN(C1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc2[nH]cc(C#N)c2c1
Show InChI InChI=1S/C22H22N8O2/c1-22(2)21-26-16-19(29-10-14(11-29)31-3)27-17(28-20(16)30(21)4-5-32-22)12-6-15-13(7-23)9-25-18(15)24-8-12/h6,8-9,14H,4-5,10-11H2,1-3H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
30.8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301648
PNG
(US10131675, Example 135)
Show SMILES Nc1ncc(cc1OC(F)F)-c1nc(N2CC3CC2C3)c2nc3COCCCn3c2n1
Show InChI InChI=1S/C20H21F2N7O2/c21-20(22)31-13-6-11(7-24-16(13)23)17-26-18-15(25-14-9-30-3-1-2-28(14)18)19(27-17)29-8-10-4-12(29)5-10/h6-7,10,12,20H,1-5,8-9H2,(H2,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
30.8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301548
PNG
(US10131675, Example 34)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CC3CCC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C24H27N7O/c1-13-10-25-20-17(13)9-15(11-26-20)19-28-21-18(27-23-24(2,3)32-7-6-30(21)23)22(29-19)31-12-14-4-5-16(31)8-14/h9-11,14,16H,4-8,12H2,1-3H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
31.8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301659
PNG
(US10131675, Example 146)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cnc2c1)N1CC2CC1C2
Show InChI InChI=1S/C21H22N8O/c1-21(2)20-25-15-18(28(20)3-4-30-21)26-16(12-7-14-17(22-8-12)24-10-23-14)27-19(15)29-9-11-5-13(29)6-11/h7-8,10-11,13H,3-6,9H2,1-2H3,(H,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
32.2n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301581
PNG
(US10131675, Example 67)
Show SMILES CC(C)c1c[nH]c2ncc(cc12)-c1nc(N2CC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C23H25F2N7O/c1-12(2)15-9-27-18-14(15)7-13(8-26-18)17-29-19(31-10-23(24,25)11-31)16-20(30-17)32-5-6-33-22(3,4)21(32)28-16/h7-9,12H,5-6,10-11H2,1-4H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
32.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301633
PNG
(US10131675, Example 119)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(OC(F)F)c1)C1CC1
Show InChI InChI=1S/C19H20F2N6O2/c1-19(2)17-25-13-12(9-3-4-9)24-15(26-16(13)27(17)5-6-28-19)10-7-11(29-18(20)21)14(22)23-8-10/h7-9,18H,3-6H2,1-2H3,(H2,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
34.3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301660
PNG
(US10131675, Example 147)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cnc2c1)N1CC2CCC1C2
Show InChI InChI=1S/C22H24N8O/c1-22(2)21-26-16-19(29(21)5-6-31-22)27-17(13-8-15-18(23-9-13)25-11-24-15)28-20(16)30-10-12-3-4-14(30)7-12/h8-9,11-12,14H,3-7,10H2,1-2H3,(H,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
39.5n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301557
PNG
(US10131675, Example 43)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(OC(F)F)c1)N1CC2CC1C2
Show InChI InChI=1S/C21H23F2N7O2/c1-21(2)19-26-14-17(29(19)3-4-31-21)27-16(28-18(14)30-9-10-5-12(30)6-10)11-7-13(32-20(22)23)15(24)25-8-11/h7-8,10,12,20H,3-6,9H2,1-2H3,(H2,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
41.8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301610
PNG
(US10131675, Example 96)
Show SMILES C[C@@H]1COC(C)(C)c2nc3c(nc(nc3n12)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C20H24N8O/c1-10-9-29-20(2,3)18-24-14-16(27-8-11-4-13(27)5-11)25-15(26-17(14)28(10)18)12-6-22-19(21)23-7-12/h6-7,10-11,13H,4-5,8-9H2,1-3H3,(H2,21,22,23)/t10-,11?,13?/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
42n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301539
PNG
(US10131675, Example 25)
Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CC3COCC3C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C24H27N7O2/c1-13-7-25-20-17(13)6-14(8-26-20)19-28-21(30-9-15-11-32-12-16(15)10-30)18-22(29-19)31-4-5-33-24(2,3)23(31)27-18/h6-8,15-16H,4-5,9-12H2,1-3H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
46.3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301628
PNG
(US10131675, Example 114)
Show SMILES Nc1ncc(cn1)-c1nc(N2CC3CC2C3)c2nc3n(CCOC33CCC3)c2n1
Show InChI InChI=1S/C20H22N8O/c21-19-22-8-12(9-23-19)15-25-16-14(17(26-15)28-10-11-6-13(28)7-11)24-18-20(2-1-3-20)29-5-4-27(16)18/h8-9,11,13H,1-7,10H2,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
52.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301661
PNG
(US10131675, Example 148)
Show SMILES CC1(C)OCCn2c1nc1c(nc(cc21)-c1cnc(N)c(OC(F)F)c1)C1CC1
Show InChI InChI=1S/C20H21F2N5O2/c1-20(2)18-26-16-13(27(18)5-6-28-20)8-12(25-15(16)10-3-4-10)11-7-14(29-19(21)22)17(23)24-9-11/h7-10,19H,3-6H2,1-2H3,(H2,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
56.9n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301537
PNG
(US10131675, Example 23)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]ccc2c1)N1CC2CC1C2
Show InChI InChI=1S/C22H23N7O/c1-22(2)21-25-16-19(28(21)5-6-30-22)26-18(14-9-13-3-4-23-17(13)24-10-14)27-20(16)29-11-12-7-15(29)8-12/h3-4,9-10,12,15H,5-8,11H2,1-2H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
57.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301621
PNG
(US10131675, Example 107)
Show SMILES C[C@@H]1OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C18H20N8O/c1-9-15-22-13-16(25(15)2-3-27-9)23-14(11-6-20-18(19)21-7-11)24-17(13)26-8-10-4-12(26)5-10/h6-7,9-10,12H,2-5,8H2,1H3,(H2,19,20,21)/t9-,10?,12?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
59.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301637
PNG
(US10131675, Example 123)
Show SMILES CC1(C)OCCn2c1nc1c(NC3CCCC3)nc(nc21)-c1cnc(N)nc1
Show InChI InChI=1S/C19H24N8O/c1-19(2)17-24-13-15(23-12-5-3-4-6-12)25-14(11-9-21-18(20)22-10-11)26-16(13)27(17)7-8-28-19/h9-10,12H,3-8H2,1-2H3,(H2,20,21,22)(H,23,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
60.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301644
PNG
(US10131675, Example 131)
Show SMILES COC1CN(C1)c1nc(nc2n3CCOCCc3nc12)-c1cnc2[nH]cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N7O2/c1-32-12-9-30(10-12)19-16-20(31-3-5-33-4-2-15(31)27-16)29-17(28-19)11-6-13-14(21(22,23)24)8-26-18(13)25-7-11/h6-8,12H,2-5,9-10H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
60.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301611
PNG
(US10131675, Example 97)
Show SMILES C[C@H]1COC(C)(C)c2nc3c(nc(nc3n12)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C20H24N8O/c1-10-9-29-20(2,3)18-24-14-16(27-8-11-4-13(27)5-11)25-15(26-17(14)28(10)18)12-6-22-19(21)23-7-12/h6-7,10-11,13H,4-5,8-9H2,1-3H3,(H2,21,22,23)/t10-,11?,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
62n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301653
PNG
(US10131675, Example 140)
Show SMILES CO[C@@H]1CC2CC1CN2c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C21H26N8O2/c1-21(2)19-25-15-17(28(19)4-5-31-21)26-16(12-8-23-20(22)24-9-12)27-18(15)29-10-11-6-13(29)7-14(11)30-3/h8-9,11,13-14H,4-7,10H2,1-3H3,(H2,22,23,24)/t11?,13?,14-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
72.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301662
PNG
(US10131675, Example 149)
Show SMILES COC1CN(C1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)c(OC(F)F)c1
Show InChI InChI=1S/C20H23F2N7O3/c1-20(2)18-25-13-16(28-8-11(9-28)30-3)26-15(27-17(13)29(18)4-5-31-20)10-6-12(32-19(21)22)14(23)24-7-10/h6-7,11,19H,4-5,8-9H2,1-3H3,(H2,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
73.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301638
PNG
(US10131675, Example 124)
Show SMILES CC1(C)OCCn2c1nc1c(NC3CCC3)nc(nc21)-c1cnc(N)nc1
Show InChI InChI=1S/C18H22N8O/c1-18(2)16-23-12-14(22-11-4-3-5-11)24-13(10-8-20-17(19)21-9-10)25-15(12)26(16)6-7-27-18/h8-9,11H,3-7H2,1-2H3,(H2,19,20,21)(H,22,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
73.9n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301651
PNG
(US10131675, Example 138)
Show SMILES C[C@@H]1Cn2c(nc3c(nc(nc23)-c2cnc(N)nc2)N2CC3CC2C3)C(C)(C)O1
Show InChI InChI=1S/C20H24N8O/c1-10-8-28-17-14(24-18(28)20(2,3)29-10)16(27-9-11-4-13(27)5-11)25-15(26-17)12-6-22-19(21)23-7-12/h6-7,10-11,13H,4-5,8-9H2,1-3H3,(H2,21,22,23)/t10-,11?,13?/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
82.5n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301576
PNG
(US10131675, Example 62)
Show SMILES CCN(C1CCC1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C20H26N8O/c1-4-27(13-6-5-7-13)16-14-17(28-8-9-29-20(2,3)18(28)24-14)26-15(25-16)12-10-22-19(21)23-11-12/h10-11,13H,4-9H2,1-3H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
86.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301572
PNG
(US10131675, Example 58)
Show SMILES CN(C1CCC1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C19H24N8O/c1-19(2)17-23-13-15(26(3)12-5-4-6-12)24-14(11-9-21-18(20)22-10-11)25-16(13)27(17)7-8-28-19/h9-10,12H,4-8H2,1-3H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
87.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301547
PNG
(US10131675, Example 33)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CCC1C2
Show InChI InChI=1S/C20H24N8O/c1-20(2)18-24-14-16(27(18)5-6-29-20)25-15(12-8-22-19(21)23-9-12)26-17(14)28-10-11-3-4-13(28)7-11/h8-9,11,13H,3-7,10H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
90.3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301612
PNG
(US10131675, Example 98)
Show SMILES Nc1ncc(cn1)-c1nc(N2CC3CC2C3)c2nc3[C@@H](OCCn3c2n1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N8O/c19-18(20,21)12-16-25-11-14(28(16)1-2-30-12)26-13(9-5-23-17(22)24-6-9)27-15(11)29-7-8-3-10(29)4-8/h5-6,8,10,12H,1-4,7H2,(H2,22,23,24)/t8?,10?,12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
93.8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301590
PNG
(US10131675, Example 76)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCC(F)(F)C1
Show InChI InChI=1S/C18H20F2N8O/c1-17(2)15-24-11-13(27-4-3-18(19,20)9-27)25-12(10-7-22-16(21)23-8-10)26-14(11)28(15)5-6-29-17/h7-8H,3-6,9H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
97.6n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301615
PNG
(US10131675, Example 101)
Show SMILES C[C@@H]1COC(C)(C)c2nc3c(nc(nc3n12)-c1cnc(N)nc1)C1CC1
Show InChI InChI=1S/C18H21N7O/c1-9-8-26-18(2,3)16-23-13-12(10-4-5-10)22-14(24-15(13)25(9)16)11-6-20-17(19)21-7-11/h6-7,9-10H,4-5,8H2,1-3H3,(H2,19,20,21)/t9-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
102n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301585
PNG
(US10131675, Example 71)
Show SMILES CC(C)Oc1cc(cnc1N)-c1nc(N2CC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C21H25F2N7O2/c1-11(2)32-13-7-12(8-25-15(13)24)16-27-17(29-9-21(22,23)10-29)14-18(28-16)30-5-6-31-20(3,4)19(30)26-14/h7-8,11H,5-6,9-10H2,1-4H3,(H2,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
104n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301589
PNG
(US10131675, Example 75)
Show SMILES CC(C)c1c[nH]c2ncc(cc12)-c1nc(N2CCC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C24H27F2N7O/c1-13(2)16-11-28-19-15(16)9-14(10-27-19)18-30-20(32-6-5-24(25,26)12-32)17-21(31-18)33-7-8-34-23(3,4)22(33)29-17/h9-11,13H,5-8,12H2,1-4H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
112n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301663
PNG
(US10131675, Example 150)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(c1)C(F)(F)F)N1CC2CC1C2
Show InChI InChI=1S/C21H22F3N7O/c1-20(2)19-27-14-17(30(19)3-4-32-20)28-16(29-18(14)31-9-10-5-12(31)6-10)11-7-13(21(22,23)24)15(25)26-8-11/h7-8,10,12H,3-6,9H2,1-2H3,(H2,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
112n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301664
PNG
(US10131675, Example 151)
Show SMILES C[C@H]1Cn2c(nc3c(nc(nc23)-c2cnc(N)nc2)N2CC3CC2C3)[C@@H](C)O1
Show InChI InChI=1S/C19H22N8O/c1-9-7-27-16(10(2)28-9)23-14-17(26-8-11-3-13(26)4-11)24-15(25-18(14)27)12-5-21-19(20)22-6-12/h5-6,9-11,13H,3-4,7-8H2,1-2H3,(H2,20,21,22)/t9-,10+,11?,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
120n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301560
PNG
(US10131675, Example 46)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C19H22N8O/c1-19(2)17-23-13-15(26(17)3-4-28-19)24-14(11-7-21-18(20)22-8-11)25-16(13)27-9-10-5-12(27)6-10/h7-8,10,12H,3-6,9H2,1-2H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301607
PNG
(US10131675, Example 93)
Show SMILES CC[C@@]1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C20H24N8O/c1-3-20(2)18-24-14-16(27(18)4-5-29-20)25-15(12-8-22-19(21)23-9-12)26-17(14)28-10-11-6-13(28)7-11/h8-9,11,13H,3-7,10H2,1-2H3,(H2,21,22,23)/t11?,13?,20-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
131n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301652
PNG
(US10131675, Example 139)
Show SMILES C[C@H]1Cn2c(nc3c(nc(nc23)-c2cnc(N)nc2)N2CC3CC2C3)C(C)(C)O1
Show InChI InChI=1S/C20H24N8O/c1-10-8-28-17-14(24-18(28)20(2,3)29-10)16(27-9-11-4-13(27)5-11)25-15(26-17)12-6-22-19(21)23-7-12/h6-7,10-11,13H,4-5,8-9H2,1-3H3,(H2,21,22,23)/t10-,11?,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
149n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301641
PNG
(US10131675, Example 127)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c2nc[nH]c12)C1CC1
Show InChI InChI=1S/C19H20N8O/c1-19(2)18-25-14-11(9-3-4-9)24-16(26-17(14)27(18)5-6-28-19)10-7-21-15(20)13-12(10)22-8-23-13/h7-9H,3-6H2,1-2H3,(H2,20,21)(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301616
PNG
(US10131675, Example 102)
Show SMILES C[C@H]1COC(C)(C)c2nc3c(nc(nc3n12)-c1cnc(N)nc1)C1CC1
Show InChI InChI=1S/C18H21N7O/c1-9-8-26-18(2,3)16-23-13-12(10-4-5-10)22-14(24-15(13)25(9)16)11-6-20-17(19)21-7-11/h6-7,9-10H,4-5,8H2,1-3H3,(H2,19,20,21)/t9-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
157n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301525
PNG
(US10131675, Example 10)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC(F)(F)C2C1
Show InChI InChI=1S/C20H22F2N8O/c1-19(2)17-26-13-15(29-8-10-5-20(21,22)12(10)9-29)27-14(11-6-24-18(23)25-7-11)28-16(13)30(17)3-4-31-19/h6-7,10,12H,3-5,8-9H2,1-2H3,(H2,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
157n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301534
PNG
(US10131675, Example 20)
Show SMILES CCc1n[nH]c2ncc(cc12)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C23H26N8O/c1-4-16-15-9-13(10-24-19(15)29-28-16)18-26-20-17(21(27-18)31-11-12-7-14(31)8-12)25-22-23(2,3)32-6-5-30(20)22/h9-10,12,14H,4-8,11H2,1-3H3,(H,24,28,29)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
161n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301650
PNG
(US10131675, Example 137)
Show SMILES CC1(C)OCCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C20H24N8O/c1-20(2)18-24-14-16(27(18)4-3-5-29-20)25-15(12-8-22-19(21)23-9-12)26-17(14)28-10-11-6-13(28)7-11/h8-9,11,13H,3-7,10H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
177n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301665
PNG
(US10131675, Example 152)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cc(F)c2c1)N1CC(C1)C#N
Show InChI InChI=1S/C21H19FN8O/c1-21(2)20-26-15-18(29-9-11(6-23)10-29)27-16(28-19(15)30(20)3-4-31-21)12-5-13-14(22)8-25-17(13)24-7-12/h5,7-8,11H,3-4,9-10H2,1-2H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
183n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301573
PNG
(US10131675, Example 59)
Show SMILES CC1(C)OCCn2c1nc1c(NC3CC3)nc(nc21)-c1cnc(N)nc1
Show InChI InChI=1S/C17H20N8O/c1-17(2)15-22-11-13(21-10-3-4-10)23-12(9-7-19-16(18)20-8-9)24-14(11)25(15)5-6-26-17/h7-8,10H,3-6H2,1-2H3,(H2,18,19,20)(H,21,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
192n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301522
PNG
(US10131675, Example 7)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCC2CC12
Show InChI InChI=1S/C19H22N8O/c1-19(2)17-23-13-15(26-4-3-10-7-12(10)26)24-14(11-8-21-18(20)22-9-11)25-16(13)27(17)5-6-28-19/h8-10,12H,3-7H2,1-2H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
199n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301571
PNG
(US10131675, Example 57)
Show SMILES COc1cc(cnc1N)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C21H25N7O2/c1-21(2)20-24-15-18(27(20)4-5-30-21)25-17(12-8-14(29-3)16(22)23-9-12)26-19(15)28-10-11-6-13(28)7-11/h8-9,11,13H,4-7,10H2,1-3H3,(H2,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301574
PNG
(US10131675, Example 60)
Show SMILES CN(C1CC1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C18H22N8O/c1-18(2)16-22-12-14(25(3)11-4-5-11)23-13(10-8-20-17(19)21-9-10)24-15(12)26(16)6-7-27-18/h8-9,11H,4-7H2,1-3H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
207n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301647
PNG
(US10131675, Example 134)
Show SMILES CC1(C)OCCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCCC1
Show InChI InChI=1S/C19H24N8O/c1-19(2)17-23-13-15(26-6-3-4-7-26)24-14(12-10-21-18(20)22-11-12)25-16(13)27(17)8-5-9-28-19/h10-11H,3-9H2,1-2H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
210n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301540
PNG
(US10131675, Example 26)
Show SMILES C[C@@H]1CCCN1c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C19H24N8O/c1-11-5-4-6-26(11)15-13-16(27-7-8-28-19(2,3)17(27)23-13)25-14(24-15)12-9-21-18(20)22-10-12/h9-11H,4-8H2,1-3H3,(H2,20,21,22)/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
210n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301619
PNG
(US10131675, Example 105)
Show SMILES C[C@@]1(OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)C1CC1)C1CC1
Show InChI InChI=1S/C19H21N7O/c1-19(12-4-5-12)17-24-14-13(10-2-3-10)23-15(11-8-21-18(20)22-9-11)25-16(14)26(17)6-7-27-19/h8-10,12H,2-7H2,1H3,(H2,20,21,22)/t19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
211n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301655
PNG
(US10131675, Example 142)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C[C@H]2F
Show InChI InChI=1S/C20H23FN8O/c1-20(2)18-25-14-16(28(18)3-4-30-20)26-15(11-7-23-19(22)24-8-11)27-17(14)29-9-10-5-12(29)6-13(10)21/h7-8,10,12-13H,3-6,9H2,1-2H3,(H2,22,23,24)/t10?,12?,13-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
216n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301656
PNG
(US10131675, Example 143)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C[C@@H]2F
Show InChI InChI=1S/C20H23FN8O/c1-20(2)18-25-14-16(28(18)3-4-30-20)26-15(11-7-23-19(22)24-8-11)27-17(14)29-9-10-5-12(29)6-13(10)21/h7-8,10,12-13H,3-6,9H2,1-2H3,(H2,22,23,24)/t10?,12?,13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
223n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301524
PNG
(US10131675, Example 9)
Show SMILES COC1C2CCC1N(C2)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C21H26N8O2/c1-21(2)19-25-14-17(28(19)6-7-31-21)26-16(12-8-23-20(22)24-9-12)27-18(14)29-10-11-4-5-13(29)15(11)30-3/h8-9,11,13,15H,4-7,10H2,1-3H3,(H2,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
223n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301614
PNG
(US10131675, Example 100)
Show SMILES CC1(OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C2)C(F)(F)F
Show InChI InChI=1S/C19H19F3N8O/c1-18(19(20,21)22)16-26-12-14(29(16)2-3-31-18)27-13(10-6-24-17(23)25-7-10)28-15(12)30-8-9-4-11(30)5-9/h6-7,9,11H,2-5,8H2,1H3,(H2,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
225n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301629
PNG
(US10131675, Example 115)
Show SMILES Nc1ncc(cn1)-c1nc(C2CC2)c2nc3n(CCOC33CCC3)c2n1
Show InChI InChI=1S/C18H19N7O/c19-17-20-8-11(9-21-17)14-22-12(10-2-3-10)13-15(24-14)25-6-7-26-18(4-1-5-18)16(25)23-13/h8-10H,1-7H2,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
226n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301586
PNG
(US10131675, Example 72)
Show SMILES CCC(C)Oc1cc(cnc1N)-c1nc(N2CC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C22H27F2N7O2/c1-5-12(2)33-14-8-13(9-26-16(14)25)17-28-18(30-10-22(23,24)11-30)15-19(29-17)31-6-7-32-21(3,4)20(31)27-15/h8-9,12H,5-7,10-11H2,1-4H3,(H2,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
230n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301549
PNG
(US10131675, Example 35)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(Cl)c1)N1CC2CC1C2
Show InChI InChI=1S/C20H22ClN7O/c1-20(2)19-24-14-17(27(19)3-4-29-20)25-16(11-7-13(21)15(22)23-8-11)26-18(14)28-9-10-5-12(28)6-10/h7-8,10,12H,3-6,9H2,1-2H3,(H2,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
235n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301622
PNG
(US10131675, Example 108)
Show SMILES C[C@H]1OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C18H20N8O/c1-9-15-22-13-16(25(15)2-3-27-9)23-14(11-6-20-18(19)21-7-11)24-17(13)26-8-10-4-12(26)5-10/h6-7,9-10,12H,2-5,8H2,1H3,(H2,19,20,21)/t9-,10?,12?/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
239n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301542
PNG
(US10131675, Example 28)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCC(C1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N8O/c1-18(2)16-26-12-14(29-4-3-11(9-29)19(20,21)22)27-13(10-7-24-17(23)25-8-10)28-15(12)30(16)5-6-31-18/h7-8,11H,3-6,9H2,1-2H3,(H2,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
245n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301575
PNG
(BDBM301631 | US10131675, Example 61)
Show SMILES CCN(C1CC1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C19H24N8O/c1-4-26(12-5-6-12)15-13-16(27-7-8-28-19(2,3)17(27)23-13)25-14(24-15)11-9-21-18(20)22-10-11/h9-10,12H,4-8H2,1-3H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
250n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301666
PNG
(US10131675, Example 153)
Show SMILES C[C@H]1Cn2c(nc3c(nc(nc23)-c2cnc(N)nc2)N2CC3CC2C3)[C@H](C)O1
Show InChI InChI=1S/C19H22N8O/c1-9-7-27-16(10(2)28-9)23-14-17(26-8-11-3-13(26)4-11)24-15(25-18(14)27)12-5-21-19(20)22-6-12/h5-6,9-11,13H,3-4,7-8H2,1-2H3,(H2,20,21,22)/t9-,10-,11?,13?/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
261n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301526
PNG
(US10131675, Example 11)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1CC2(F)F
Show InChI InChI=1S/C20H22F2N8O/c1-19(2)17-26-13-15(29(17)3-4-31-19)27-14(10-7-24-18(23)25-8-10)28-16(13)30-9-11-5-12(30)6-20(11,21)22/h7-8,11-12H,3-6,9H2,1-2H3,(H2,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
262n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301640
PNG
(US10131675, Example 126)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(c1)C#N)C1CC1
Show InChI InChI=1S/C19H19N7O/c1-19(2)18-24-14-13(10-3-4-10)23-16(25-17(14)26(18)5-6-27-19)12-7-11(8-20)15(21)22-9-12/h7,9-10H,3-6H2,1-2H3,(H2,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
264n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301578
PNG
(US10131675, Example 64)
Show SMILES CC(C)N(C1CCC1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C21H28N8O/c1-12(2)29(14-6-5-7-14)18-15-17(28-8-9-30-21(3,4)19(28)25-15)26-16(27-18)13-10-23-20(22)24-11-13/h10-12,14H,5-9H2,1-4H3,(H2,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
267n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301593
PNG
(US10131675, Example 79)
Show SMILES CC(C)Oc1cc(cnc1N)-c1nc(N2CCC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C22H27F2N7O2/c1-12(2)33-14-9-13(10-26-16(14)25)17-28-18(30-6-5-22(23,24)11-30)15-19(29-17)31-7-8-32-21(3,4)20(31)27-15/h9-10,12H,5-8,11H2,1-4H3,(H2,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
269n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301563
PNG
(US10131675, Example 49)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(c1)C(F)(F)F)N1CCC2(COC2)C1
Show InChI InChI=1S/C22H24F3N7O2/c1-20(2)19-28-14-17(31-4-3-21(9-31)10-33-11-21)29-16(30-18(14)32(19)5-6-34-20)12-7-13(22(23,24)25)15(26)27-8-12/h7-8H,3-6,9-11H2,1-2H3,(H2,26,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
270n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301595
PNG
(US10131675, Example 81)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(Cl)c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C19H20ClF2N7O/c1-18(2)17-25-12-15(28-4-3-19(21,22)9-28)26-14(10-7-11(20)13(23)24-8-10)27-16(12)29(17)5-6-30-18/h7-8H,3-6,9H2,1-2H3,(H2,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
272n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301535
PNG
(US10131675, Example 21)
Show SMILES CCOc1cc(cnc1N)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C22H27N7O2/c1-4-30-15-9-13(10-24-17(15)23)18-26-19-16(20(27-18)29-11-12-7-14(29)8-12)25-21-22(2,3)31-6-5-28(19)21/h9-10,12,14H,4-8,11H2,1-3H3,(H2,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
279n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301596
PNG
(US10131675, Example 82)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(F)c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C19H20F3N7O/c1-18(2)17-25-12-15(28-4-3-19(21,22)9-28)26-14(10-7-11(20)13(23)24-8-10)27-16(12)29(17)5-6-30-18/h7-8H,3-6,9H2,1-2H3,(H2,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
280n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301552
PNG
(US10131675, Example 38)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2ccnn2c1)N1CC2CC1C2
Show InChI InChI=1S/C21H22N8O/c1-21(2)20-24-16-18(27(20)5-6-30-21)25-17(13-9-22-15-3-4-23-29(15)11-13)26-19(16)28-10-12-7-14(28)8-12/h3-4,9,11-12,14H,5-8,10H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
280n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301645
PNG
(US10131675, Example 132)
Show SMILES Nc1ncc(cn1)-c1nc(N2CC3CC2C3)c2nc3COCCCn3c2n1
Show InChI InChI=1S/C18H20N8O/c19-18-20-6-11(7-21-18)15-23-16-14(22-13-9-27-3-1-2-25(13)16)17(24-15)26-8-10-4-12(26)5-10/h6-7,10,12H,1-5,8-9H2,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
281n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301608
PNG
(US10131675, Example 94)
Show SMILES CC[C@]1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC1C2
Show InChI InChI=1S/C20H24N8O/c1-3-20(2)18-24-14-16(27(18)4-5-29-20)25-15(12-8-22-19(21)23-9-12)26-17(14)28-10-11-6-13(28)7-11/h8-9,11,13H,3-7,10H2,1-2H3,(H2,21,22,23)/t11?,13?,20-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
281n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301568
PNG
(US10131675, Example 54)
Show SMILES CC1CCC(C)N1c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C20H26N8O/c1-11-5-6-12(2)28(11)17-14-16(27-7-8-29-20(3,4)18(27)24-14)25-15(26-17)13-9-22-19(21)23-10-13/h9-12H,5-8H2,1-4H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
284n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301583
PNG
(US10131675, Example 69)
Show SMILES CCOc1cc(cnc1N)-c1nc(N2CC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C20H23F2N7O2/c1-4-30-12-7-11(8-24-14(12)23)15-26-16(28-9-20(21,22)10-28)13-17(27-15)29-5-6-31-19(2,3)18(29)25-13/h7-8H,4-6,9-10H2,1-3H3,(H2,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
289n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301538
PNG
(US10131675, Example 24)
Show SMILES CCC1CCCN1c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C20H26N8O/c1-4-13-6-5-7-27(13)16-14-17(28-8-9-29-20(2,3)18(28)24-14)26-15(25-16)12-10-22-19(21)23-11-12/h10-11,13H,4-9H2,1-3H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
294n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301543
PNG
(US10131675, Example 29)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1C[C@H](F)[C@H](F)C1
Show InChI InChI=1S/C18H20F2N8O/c1-18(2)16-24-12-14(27-7-10(19)11(20)8-27)25-13(9-5-22-17(21)23-6-9)26-15(12)28(16)3-4-29-18/h5-6,10-11H,3-4,7-8H2,1-2H3,(H2,21,22,23)/t10-,11+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
297n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301587
PNG
(US10131675, Example 73)
Show SMILES COc1cc(cnc1N)-c1nc(N2CCC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C20H23F2N7O2/c1-19(2)18-25-13-16(28-5-4-20(21,22)10-28)26-15(27-17(13)29(18)6-7-31-19)11-8-12(30-3)14(23)24-9-11/h8-9H,4-7,10H2,1-3H3,(H2,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
297n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301618
PNG
(US10131675, Example 104)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)C1CCC1
Show InChI InChI=1S/C18H21N7O/c1-18(2)16-23-13-12(10-4-3-5-10)22-14(11-8-20-17(19)21-9-11)24-15(13)25(16)6-7-26-18/h8-10H,3-7H2,1-2H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
297n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301541
PNG
(US10131675, Example 27)
Show SMILES CC1CCN(C1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C19H24N8O/c1-11-4-5-26(10-11)15-13-16(27-6-7-28-19(2,3)17(27)23-13)25-14(24-15)12-8-21-18(20)22-9-12/h8-9,11H,4-7,10H2,1-3H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
299n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301636
PNG
(US10131675, Example 122)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)C1CC1
Show InChI InChI=1S/C17H19N7O/c1-17(2)15-22-12-11(9-3-4-9)21-13(10-7-19-16(18)20-8-10)23-14(12)24(15)5-6-25-17/h7-9H,3-6H2,1-2H3,(H2,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
307n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301531
PNG
(US10131675, Example 16)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCCC11CCOC1
Show InChI InChI=1S/C21H26N8O2/c1-20(2)18-25-14-16(28(18)7-9-31-20)26-15(13-10-23-19(22)24-11-13)27-17(14)29-6-3-4-21(29)5-8-30-12-21/h10-11H,3-9,12H2,1-2H3,(H2,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
320n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301520
PNG
(US10131675, Example 5)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC2C1
Show InChI InChI=1S/C19H22N8O/c1-19(2)17-23-13-15(26-8-10-5-11(10)9-26)24-14(12-6-21-18(20)22-7-12)25-16(13)27(17)3-4-28-19/h6-7,10-11H,3-5,8-9H2,1-2H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
328n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301602
PNG
(US10131675, Example 88)
Show SMILES CC1(C)OCCn2c1nc1c(OC3CCC3)nc(nc21)-c1cnc(N)nc1
Show InChI InChI=1S/C18H21N7O2/c1-18(2)16-22-12-14(25(16)6-7-26-18)23-13(10-8-20-17(19)21-9-10)24-15(12)27-11-4-3-5-11/h8-9,11H,3-7H2,1-2H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
330n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301570
PNG
(US10131675, Example 56)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1C2CCC1CC2
Show InChI InChI=1S/C20H24N8O/c1-20(2)18-24-14-16(27(18)7-8-29-20)25-15(11-9-22-19(21)23-10-11)26-17(14)28-12-3-4-13(28)6-5-12/h9-10,12-13H,3-8H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
339n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301598
PNG
(US10131675, Example 84)
Show SMILES CC1(C)OCCn2c1nc1c(OC3CCCC3)nc(nc21)-c1cnc(N)nc1
Show InChI InChI=1S/C19H23N7O2/c1-19(2)17-23-13-15(26(17)7-8-27-19)24-14(11-9-21-18(20)22-10-11)25-16(13)28-12-5-3-4-6-12/h9-10,12H,3-8H2,1-2H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
357n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301634
PNG
(US10131675, Example 120)
Show SMILES CC1(C)OCCn2c1nc1c(nc(cc21)-c1cnc(N)nc1)C1CC1
Show InChI InChI=1S/C18H20N6O/c1-18(2)16-23-15-13(24(16)5-6-25-18)7-12(22-14(15)10-3-4-10)11-8-20-17(19)21-9-11/h7-10H,3-6H2,1-2H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
359n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301530
PNG
(US10131675, Example 15)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1C[C@H]2CCC(F)(F)[C@H]2C1
Show InChI InChI=1S/C21H24F2N8O/c1-20(2)18-27-14-16(30-9-11-3-4-21(22,23)13(11)10-30)28-15(12-7-25-19(24)26-8-12)29-17(14)31(18)5-6-32-20/h7-8,11,13H,3-6,9-10H2,1-2H3,(H2,24,25,26)/t11-,13+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
360n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301569
PNG
(US10131675, Example 55)
Show SMILES C[C@H]1CC[C@@H](C)N1c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C20H26N8O/c1-11-5-6-12(2)28(11)17-14-16(27-7-8-29-20(3,4)18(27)24-14)25-15(26-17)13-9-22-19(21)23-10-13/h9-12H,5-8H2,1-4H3,(H2,21,22,23)/t11-,12+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
371n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301623
PNG
(US10131675, Example 109)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cnc2c1)N1CC(O)C1
Show InChI InChI=1S/C19H20N8O2/c1-19(2)18-23-13-16(26-7-11(28)8-26)24-14(25-17(13)27(18)3-4-29-19)10-5-12-15(20-6-10)22-9-21-12/h5-6,9,11,28H,3-4,7-8H2,1-2H3,(H,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
379n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301620
PNG
(US10131675, Example 106)
Show SMILES C[C@]1(OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)C1CC1)C1CC1
Show InChI InChI=1S/C19H21N7O/c1-19(12-4-5-12)17-24-14-13(10-2-3-10)23-15(11-8-21-18(20)22-9-11)25-16(14)26(17)6-7-27-19/h8-10,12H,2-7H2,1H3,(H2,20,21,22)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
385n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301517
PNG
(US10131675, Example 2)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC(F)C1
Show InChI InChI=1S/C17H19FN8O/c1-17(2)15-22-11-13(25-7-10(18)8-25)23-12(9-5-20-16(19)21-6-9)24-14(11)26(15)3-4-27-17/h5-6,10H,3-4,7-8H2,1-2H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
391n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301516
PNG
(US10131675, Example 1)
Show SMILES COCC1CCCN1c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C20H26N8O2/c1-20(2)18-24-14-16(27-6-4-5-13(27)11-29-3)25-15(12-9-22-19(21)23-10-12)26-17(14)28(18)7-8-30-20/h9-10,13H,4-8,11H2,1-3H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
392n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301654
PNG
(US10131675, Example 141)
Show SMILES CO[C@H]1CC2CC1CN2c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C21H26N8O2/c1-21(2)19-25-15-17(28(19)4-5-31-21)26-16(12-8-23-20(22)24-9-12)27-18(15)29-10-11-6-13(29)7-14(11)30-3/h8-9,11,13-14H,4-7,10H2,1-3H3,(H2,22,23,24)/t11?,13?,14-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
392n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301532
PNG
(US10131675, Example 18)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCCC1
Show InChI InChI=1S/C18H22N8O/c1-18(2)16-22-12-14(25-5-3-4-6-25)23-13(11-9-20-17(19)21-10-11)24-15(12)26(16)7-8-27-18/h9-10H,3-8H2,1-2H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
402n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301536
PNG
(US10131675, Example 22)
Show SMILES CC(C)Oc1cc(cnc1N)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C23H29N7O2/c1-12(2)32-16-9-14(10-25-18(16)24)19-27-20-17(21(28-19)30-11-13-7-15(30)8-13)26-22-23(3,4)31-6-5-29(20)22/h9-10,12-13,15H,5-8,11H2,1-4H3,(H2,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
406n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301584
PNG
(US10131675, Example 70)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(OCC2CC2)c1)N1CC(F)(F)C1
Show InChI InChI=1S/C22H25F2N7O2/c1-21(2)20-27-15-18(30-10-22(23,24)11-30)28-17(29-19(15)31(20)5-6-33-21)13-7-14(16(25)26-8-13)32-9-12-3-4-12/h7-8,12H,3-6,9-11H2,1-2H3,(H2,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
417n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301545
PNG
(US10131675, Example 31)
Show SMILES CC1(C)CN(C1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C19H24N8O/c1-18(2)9-26(10-18)14-12-15(27-5-6-28-19(3,4)16(27)23-12)25-13(24-14)11-7-21-17(20)22-8-11/h7-8H,5-6,9-10H2,1-4H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
424n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301594
PNG
(US10131675, Example 80)
Show SMILES CCC(C)Oc1cc(cnc1N)-c1nc(N2CCC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C23H29F2N7O2/c1-5-13(2)34-15-10-14(11-27-17(15)26)18-29-19(31-7-6-23(24,25)12-31)16-20(30-18)32-8-9-33-22(3,4)21(32)28-16/h10-11,13H,5-9,12H2,1-4H3,(H2,26,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
443n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301550
PNG
(US10131675, Example 36)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(F)c1)N1CC2CC1C2
Show InChI InChI=1S/C20H22FN7O/c1-20(2)19-24-14-17(27(19)3-4-29-20)25-16(11-7-13(21)15(22)23-8-11)26-18(14)28-9-10-5-12(28)6-10/h7-8,10,12H,3-6,9H2,1-2H3,(H2,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
444n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301646
PNG
(US10131675, Example 133)
Show SMILES Nc1ncc(cn1)-c1nc(N2CC3CC2C3)c2nc3CCOCCn3c2n1
Show InChI InChI=1S/C18H20N8O/c19-18-20-7-11(8-21-18)15-23-16-14(22-13-1-3-27-4-2-25(13)16)17(24-15)26-9-10-5-12(26)6-10/h7-8,10,12H,1-6,9H2,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
447n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301626
PNG
(US10131675, Example 112)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cnc2c1)N1CC(C1)C#N
Show InChI InChI=1S/C20H19N9O/c1-20(2)19-25-14-17(28-8-11(6-21)9-28)26-15(27-18(14)29(19)3-4-30-20)12-5-13-16(22-7-12)24-10-23-13/h5,7,10-11H,3-4,8-9H2,1-2H3,(H,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
458n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301523
PNG
(US10131675, Example 8)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCC2(COC2)C1
Show InChI InChI=1S/C20H24N8O2/c1-19(2)17-24-13-15(27-4-3-20(9-27)10-29-11-20)25-14(12-7-22-18(21)23-8-12)26-16(13)28(17)5-6-30-19/h7-8H,3-6,9-11H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
469n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301609
PNG
(US10131675, Example 95)
Show SMILES CC1(CC1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C18H21N7O/c1-17(2)15-22-11-12(18(3)4-5-18)23-13(10-8-20-16(19)21-9-10)24-14(11)25(15)6-7-26-17/h8-9H,4-7H2,1-3H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
476n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301606
PNG
(US10131675, Example 92)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cncc(c1)C(F)(F)F)N1CC2CC1C2
Show InChI InChI=1S/C21H21F3N6O/c1-20(2)19-26-15-17(29(19)3-4-31-20)27-16(12-7-13(9-25-8-12)21(22,23)24)28-18(15)30-10-11-5-14(30)6-11/h7-9,11,14H,3-6,10H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
478n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301567
PNG
(US10131675, Example 53)
Show SMILES C[C@H]1CCCN1c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C19H24N8O/c1-11-5-4-6-26(11)15-13-16(27-7-8-28-19(2,3)17(27)23-13)25-14(24-15)12-9-21-18(20)22-10-12/h9-11H,4-8H2,1-3H3,(H2,20,21,22)/t11-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
479n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301582
PNG
(US10131675, Example 68)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC(F)(F)C1
Show InChI InChI=1S/C17H18F2N8O/c1-16(2)14-23-10-12(26-7-17(18,19)8-26)24-11(9-5-21-15(20)22-6-9)25-13(10)27(14)3-4-28-16/h5-6H,3-4,7-8H2,1-2H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
480n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301564
PNG
(US10131675, Example 50)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2(COC2)C1
Show InChI InChI=1S/C19H22N8O2/c1-18(2)16-23-12-14(26-7-19(8-26)9-28-10-19)24-13(11-5-21-17(20)22-6-11)25-15(12)27(16)3-4-29-18/h5-6H,3-4,7-10H2,1-2H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
490n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301533
PNG
(US10131675, Example 19)
Show SMILES Cc1n[nH]c2ncc(cc12)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C22H24N8O/c1-11-15-8-13(9-23-18(15)28-27-11)17-25-19-16(20(26-17)30-10-12-6-14(30)7-12)24-21-22(2,3)31-5-4-29(19)21/h8-9,12,14H,4-7,10H2,1-3H3,(H,23,27,28)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
493n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301597
PNG
(US10131675, Example 83)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2ccnn2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C20H20F2N8O/c1-19(2)18-25-14-16(28-6-4-20(21,22)11-28)26-15(27-17(14)29(18)7-8-31-19)12-9-23-13-3-5-24-30(13)10-12/h3,5,9-10H,4,6-8,11H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
497n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301566
PNG
(US10131675, Example 52)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2(CCC2)C1
Show InChI InChI=1S/C20H24N8O/c1-19(2)17-24-13-15(27-10-20(11-27)4-3-5-20)25-14(12-8-22-18(21)23-9-12)26-16(13)28(17)6-7-29-19/h8-9H,3-7,10-11H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
515n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301627
PNG
(US10131675, Example 113)
Show SMILES Cn1cc(cn1)-c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C18H19N9O/c1-18(2)16-24-13-12(11-8-22-26(3)9-11)23-14(10-6-20-17(19)21-7-10)25-15(13)27(16)4-5-28-18/h6-9H,4-5H2,1-3H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
521n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301603
PNG
(US10131675, Example 89)
Show SMILES CC1(C)OCCn2c1nc1c(OC3CC4CC4C3)nc(nc21)-c1cnc(N)nc1
Show InChI InChI=1S/C20H23N7O2/c1-20(2)18-24-14-16(27(18)3-4-28-20)25-15(12-8-22-19(21)23-9-12)26-17(14)29-13-6-10-5-11(10)7-13/h8-11,13H,3-7H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
551n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301592
PNG
(US10131675, Example 78)
Show SMILES CCOc1cc(cnc1N)-c1nc(N2CCC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C21H25F2N7O2/c1-4-31-13-9-12(10-25-15(13)24)16-27-17(29-6-5-21(22,23)11-29)14-18(28-16)30-7-8-32-20(2,3)19(30)26-14/h9-10H,4-8,11H2,1-3H3,(H2,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
558n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301577
PNG
(US10131675, Example 63)
Show SMILES CC(C)N(C1CC1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C20H26N8O/c1-11(2)28(13-5-6-13)17-14-16(27-7-8-29-20(3,4)18(27)24-14)25-15(26-17)12-9-22-19(21)23-10-12/h9-11,13H,5-8H2,1-4H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
558n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301599
PNG
(US10131675, Example 85)
Show SMILES CC(C)Oc1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C17H21N7O2/c1-9(2)26-14-11-13(24-5-6-25-17(3,4)15(24)21-11)22-12(23-14)10-7-19-16(18)20-8-10/h7-9H,5-6H2,1-4H3,(H2,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
571n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301527
PNG
(US10131675, Example 12)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCC2(CCOC2)C1
Show InChI InChI=1S/C21H26N8O2/c1-20(2)18-25-14-16(28-5-3-21(11-28)4-7-30-12-21)26-15(13-9-23-19(22)24-10-13)27-17(14)29(18)6-8-31-20/h9-10H,3-8,11-12H2,1-2H3,(H2,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
584n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301591
PNG
(US10131675, Example 77)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(OCC2CC2)c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C23H27F2N7O2/c1-22(2)21-28-16-19(31-6-5-23(24,25)12-31)29-18(30-20(16)32(21)7-8-34-22)14-9-15(17(26)27-10-14)33-11-13-3-4-13/h9-10,13H,3-8,11-12H2,1-2H3,(H2,26,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
588n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301558
PNG
(US10131675, Example 44)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(c1)C1CC1)N1CC2CC1C2
Show InChI InChI=1S/C23H27N7O/c1-23(2)22-26-17-20(29(22)5-6-31-23)27-19(28-21(17)30-11-12-7-15(30)8-12)14-9-16(13-3-4-13)18(24)25-10-14/h9-10,12-13,15H,3-8,11H2,1-2H3,(H2,24,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
621n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301639
PNG
(US10131675, Example 125)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2NCCc2c1)C1CC1
Show InChI InChI=1S/C20H22N6O/c1-20(2)19-24-15-14(11-3-4-11)23-17(25-18(15)26(19)7-8-27-20)13-9-12-5-6-21-16(12)22-10-13/h9-11H,3-8H2,1-2H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
626n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301600
PNG
(US10131675, Example 86)
Show SMILES CC1(C)OCCn2c1nc1c(OCC3CC3)nc(nc21)-c1cnc(N)nc1
Show InChI InChI=1S/C18H21N7O2/c1-18(2)16-22-12-14(25(16)5-6-27-18)23-13(11-7-20-17(19)21-8-11)24-15(12)26-9-10-3-4-10/h7-8,10H,3-6,9H2,1-2H3,(H2,19,20,21)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
634n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301551
PNG
(US10131675, Example 37)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2ccnn2c1)N1CC2CCC1C2
Show InChI InChI=1S/C22H24N8O/c1-22(2)21-25-17-19(28(21)7-8-31-22)26-18(14-10-23-16-5-6-24-30(16)12-14)27-20(17)29-11-13-3-4-15(29)9-13/h5-6,10,12-13,15H,3-4,7-9,11H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
663n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301649
PNG
(US10131675, Example 136)
Show SMILES COC1CN(C1)c1nc(nc2n3CCCOCc3nc12)-c1cnc(N)c(OC(F)F)c1
Show InChI InChI=1S/C19H21F2N7O3/c1-29-11-7-27(8-11)17-14-18(28-3-2-4-30-9-13(28)24-14)26-16(25-17)10-5-12(31-19(20)21)15(22)23-6-10/h5-6,11,19H,2-4,7-9H2,1H3,(H2,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
687n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301521
PNG
(US10131675, Example 6)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CC(F)(F)CC2C1
Show InChI InChI=1S/C21H24F2N8O/c1-20(2)18-27-14-16(30-9-11-5-21(22,23)6-12(11)10-30)28-15(13-7-25-19(24)26-8-13)29-17(14)31(18)3-4-32-20/h7-8,11-12H,3-6,9-10H2,1-2H3,(H2,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
727n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301579
PNG
(US10131675, Example 65)
Show SMILES COc1cc(cnc1N)-c1nc(N2CC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C19H21F2N7O2/c1-18(2)17-24-12-15(27-8-19(20,21)9-27)25-14(26-16(12)28(17)4-5-30-18)10-6-11(29-3)13(22)23-7-10/h6-7H,4-5,8-9H2,1-3H3,(H2,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
860n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301613
PNG
(US10131675, Example 99)
Show SMILES Nc1ncc(cn1)-c1nc(N2CC3CC2C3)c2nc3[C@H](OCCn3c2n1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N8O/c19-18(20,21)12-16-25-11-14(28(16)1-2-30-12)26-13(9-5-23-17(22)24-6-9)27-15(11)29-7-8-3-10(29)4-8/h5-6,8,10,12H,1-4,7H2,(H2,22,23,24)/t8?,10?,12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
866n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301625
PNG
(US10131675, Example 111)
Show SMILES COC1CN(C1)c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc2[nH]cnc2c1
Show InChI InChI=1S/C20H22N8O2/c1-20(2)19-24-14-17(27-8-12(9-27)29-3)25-15(26-18(14)28(19)4-5-30-20)11-6-13-16(21-7-11)23-10-22-13/h6-7,10,12H,4-5,8-9H2,1-3H3,(H,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
885n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301565
PNG
(US10131675, Example 51)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2(C1)CCCO2
Show InChI InChI=1S/C20H24N8O2/c1-19(2)17-24-13-15(27-10-20(11-27)4-3-6-30-20)25-14(12-8-22-18(21)23-9-12)26-16(13)28(17)5-7-29-19/h8-9H,3-7,10-11H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
907n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301529
PNG
(US10131675, Example 14)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2CCOC2C1
Show InChI InChI=1S/C20H24N8O2/c1-20(2)18-24-14-16(27-9-11-3-5-29-13(11)10-27)25-15(12-7-22-19(21)23-8-12)26-17(14)28(18)4-6-30-20/h7-8,11,13H,3-6,9-10H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
990n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301562
PNG
(US10131675, Example 48)
Show SMILES Cc1cc(cnc1N)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C21H25N7O/c1-11-6-13(9-23-16(11)22)17-25-18-15(19(26-17)28-10-12-7-14(28)8-12)24-20-21(2,3)29-5-4-27(18)20/h6,9,12,14H,4-5,7-8,10H2,1-3H3,(H2,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
992n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301528
PNG
(US10131675, Example 13)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CC2COCC2C1
Show InChI InChI=1S/C20H24N8O2/c1-20(2)18-24-14-16(27-7-12-9-29-10-13(12)8-27)25-15(11-5-22-19(21)23-6-11)26-17(14)28(18)3-4-30-20/h5-6,12-13H,3-4,7-10H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
995n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301617
PNG
(US10131675, Example 103)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)C1(CCC1)C#N
Show InChI InChI=1S/C19H20N8O/c1-18(2)16-24-12-13(19(10-20)4-3-5-19)25-14(11-8-22-17(21)23-9-11)26-15(12)27(16)6-7-28-18/h8-9H,3-7H2,1-2H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.00E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301632
PNG
(US10131675, Example 118)
Show SMILES CC1(C)OCCn2c1nc1c(nc(cc21)-c1cnc(N)cn1)N1CC2CC1C2
Show InChI InChI=1S/C20H23N7O/c1-20(2)19-25-17-15(26(19)3-4-28-20)7-13(14-8-23-16(21)9-22-14)24-18(17)27-10-11-5-12(27)6-11/h7-9,11-12H,3-6,10H2,1-2H3,(H2,21,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.20E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301667
PNG
(US10131675, Example 155)
Show SMILES CC(Oc1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1)C1CC1
Show InChI InChI=1S/C19H23N7O2/c1-10(11-4-5-11)28-16-13-15(26-6-7-27-19(2,3)17(26)23-13)24-14(25-16)12-8-21-18(20)22-9-12/h8-11H,4-7H2,1-3H3,(H2,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.20E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301668
PNG
(US10131675, Example 156)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)nc1)N1CCC2(CCCO2)C1
Show InChI InChI=1S/C21H26N8O2/c1-20(2)18-25-14-16(28-6-5-21(12-28)4-3-8-31-21)26-15(13-10-23-19(22)24-11-13)27-17(14)29(18)7-9-30-20/h10-11H,3-9,12H2,1-2H3,(H2,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.30E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301561
PNG
(US10131675, Example 47)
Show SMILES CNc1ncc(cn1)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1
Show InChI InChI=1S/C20H24N8O/c1-20(2)18-24-14-16(27(18)4-5-29-20)25-15(12-8-22-19(21-3)23-9-12)26-17(14)28-10-11-6-13(28)7-11/h8-9,11,13H,4-7,10H2,1-3H3,(H,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.30E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM301605
PNG
(US10131675, Example 91)
Show SMILES CC(C)n1nccc1-c1nc(nc2n3CCOC(C)(C)c3nc12)-c1cnc(N)nc1
Show InChI InChI=1S/C20H23N9O/c1-11(2)29-13(5-6-24-29)14-15-17(28-7-8-30-20(3,4)18(28)26-15)27-16(25-14)12-9-22-19(21)23-10-12/h5-6,9-11H,7-8H2,1-4H3,(H2,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.40E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...


US Patent US10131675 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%