BindingDB logo
myBDB logout

Patent code US10137210

Compile Data Set for Download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM303149
PNG
(US10137210, Example [N-methyl-11C]6-MeO-BTA-2)
Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(CO)cc2s1
Show InChI InChI=1S/C16H16N2OS/c1-18(2)13-6-4-12(5-7-13)16-17-14-8-3-11(10-19)9-15(14)20-16/h3-9,19H,10H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
2.30n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM303166
PNG
(US10137210, Example 00026)
Show SMILES CNc1ccc(cc1I)-c1nc2ccc(O)cc2s1
Show InChI InChI=1S/C14H11IN2OS/c1-16-11-4-2-8(6-10(11)15)14-17-12-5-3-9(18)7-13(12)19-14/h2-7,16,18H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
3.22n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM303164
PNG
(US10137210, Example 00024)
Show SMILES CNc1ccc(cc1I)-c1nc2ccccc2s1
Show InChI InChI=1S/C14H11IN2S/c1-16-11-7-6-9(8-10(11)15)14-17-12-4-2-3-5-13(12)18-14/h2-8,16H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
4.94n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM303148
PNG
(US10137210, Example [N-methyl-11C]6-MeO-BTA-1)
Show SMILES CNc1ccc(cc1)-c1nc2ccc(CO)cc2s1
Show InChI InChI=1S/C15H14N2OS/c1-16-12-5-3-11(4-6-12)15-17-13-7-2-10(9-18)8-14(13)19-15/h2-8,16,18H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.70n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM303156
PNG
(US10137210, Example 00023)
Show SMILES Nc1ccc(cc1I)-c1nc2ccccc2s1
Show InChI InChI=1S/C13H9IN2S/c14-9-7-8(5-6-10(9)15)13-16-11-3-1-2-4-12(11)17-13/h1-7H,15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
8.32n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM50109052
PNG
((4-Benzothiazol-2-yl-phenyl)-methyl-amine | 4-(ben...)
Show SMILES CNc1ccc(cc1)-c1nc2ccccc2s1
Show InChI InChI=1S/C14H12N2S/c1-15-11-8-6-10(7-9-11)14-16-12-4-2-3-5-13(12)17-14/h2-9,15H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
9.60n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM303165
PNG
(US10137210, Example 00025)
Show SMILES Nc1ccc(cc1I)-c1nc2ccc(O)cc2s1
Show InChI InChI=1S/C13H9IN2OS/c14-9-5-7(1-3-10(9)15)13-16-11-4-2-8(17)6-12(11)18-13/h1-6,17H,15H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
11.1n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM50109051
PNG
(CHEMBL330529 | Methyl-[4-(6-methyl-benzothiazol-2-...)
Show SMILES CNc1ccc(cc1)-c1nc2ccc(C)cc2s1
Show InChI InChI=1S/C15H14N2S/c1-10-3-8-13-14(9-10)18-15(17-13)11-4-6-12(16-2)7-5-11/h3-9,16H,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
21n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM50052701
PNG
(2-(4-Aminophenyl)-6-methoxybenzothiazole | 4-(6-Me...)
Show SMILES COc1ccc2nc(sc2c1)-c1ccc(N)cc1
Show InChI InChI=1S/C14H12N2OS/c1-17-11-6-7-12-13(8-11)18-14(16-12)9-2-4-10(15)5-3-9/h2-8H,15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
30n/an/an/an/an/an/an/an/a



The University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Initial competitive binding studies using [3H]CG and synthetic Aβ(1-40) were conducted to determine if CG, ThS and ThT bound to the same site(s)...


US Patent US10137210 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%