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Patent code US10138229

Compile Data Set for Download or QSAR
Found 156 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303609
PNG
(US10138229, Example 121)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cn1)[C@H]1C[C@]2(C1)CCCN(C2)C(=O)C=C
Show InChI InChI=1S/C26H28N6O3/c1-2-21(33)31-12-6-11-26(16-31)13-17(14-26)32-24(27)22(25(28)34)23(30-32)20-10-9-19(15-29-20)35-18-7-4-3-5-8-18/h2-5,7-10,15,17H,1,6,11-14,16,27H2,(H2,28,34)/t17-,26-
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n/an/a 0.200n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303652
PNG
(US10138229, Example 164)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(OCC(F)(F)F)cc2)C1
Show InChI InChI=1S/C23H24F3N5O3/c1-2-3-17(32)30-9-8-22(12-30)10-15(11-22)31-20(27)18(21(28)33)19(29-31)14-4-6-16(7-5-14)34-13-23(24,25)26/h4-7,15H,8-13,27H2,1H3,(H2,28,33)/t15-,22-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303606
PNG
(US10138229, Example 118 | US10138229, Example 119)
Show SMILES CC#CC(=O)N1CC[C@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cn2)C1
Show InChI InChI=1S/C26H26N6O3/c1-2-6-21(33)31-12-11-26(16-31)13-17(14-26)32-24(27)22(25(28)34)23(30-32)20-10-9-19(15-29-20)35-18-7-4-3-5-8-18/h3-5,7-10,15,17H,11-14,16,27H2,1H3,(H2,28,34)/t17-,26+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303642
PNG
(US10138229, Example 154)
Show SMILES COc1ccc(cc1)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C22H25N5O3/c1-3-4-17(28)26-10-9-22(13-26)11-15(12-22)27-20(23)18(21(24)29)19(25-27)14-5-7-16(30-2)8-6-14/h5-8,15H,9-13,23H2,1-2H3,(H2,24,29)/t15-,22-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303639
PNG
(US10138229, Example 151)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccn3)cc2)C1
Show InChI InChI=1S/C26H26N6O3/c1-2-5-21(33)31-13-11-26(16-31)14-18(15-26)32-24(27)22(25(28)34)23(30-32)17-7-9-19(10-8-17)35-20-6-3-4-12-29-20/h3-4,6-10,12,18H,11,13-16,27H2,1H3,(H2,28,34)/t18-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303586
PNG
(US10138229, Example 98)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C29H34N6O3/c1-33(2)15-6-9-24(36)34-16-14-29(19-34)17-21(18-29)35-27(30)25(28(31)37)26(32-35)20-10-12-23(13-11-20)38-22-7-4-3-5-8-22/h3-13,21H,14-19,30H2,1-2H3,(H2,31,37)/b9-6+/t21-,29+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303543
PNG
(US10138229, Example 54)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H25N5O3/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)31)22(27-29)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,25H2,(H2,26,31)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303528
PNG
(US10138229, Example 41)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C26H25N5O3/c1-2-6-21(32)30-15-26(16-30)13-18(14-26)31-24(27)22(25(28)33)23(29-31)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,18H,13-16,27H2,1H3,(H2,28,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303521
PNG
(US10138229, Example 35)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C25H25N5O3/c1-2-20(31)29-14-25(15-29)12-17(13-25)30-23(26)21(24(27)32)22(28-30)16-8-10-19(11-9-16)33-18-6-4-3-5-7-18/h2-11,17H,1,12-15,26H2,(H2,27,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303569
PNG
(US10138229, Example 81)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C26H27N5O3/c1-2-21(32)30-13-12-26(16-30)14-18(15-26)31-24(27)22(25(28)33)23(29-31)17-8-10-20(11-9-17)34-19-6-4-3-5-7-19/h2-11,18H,1,12-16,27H2,(H2,28,33)/t18-,26+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303579
PNG
(US10138229, Example 91)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C27H27N5O3/c1-2-6-22(33)31-14-13-27(17-31)15-19(16-27)32-25(28)23(26(29)34)24(30-32)18-9-11-21(12-10-18)35-20-7-4-3-5-8-20/h3-5,7-12,19H,13-17,28H2,1H3,(H2,29,34)/t19-,27-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303638
PNG
(US10138229, Example 150)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)nc2)C1
Show InChI InChI=1S/C26H26N6O3/c1-2-6-21(33)31-12-11-26(16-31)13-18(14-26)32-24(27)22(25(28)34)23(30-32)17-9-10-20(29-15-17)35-19-7-4-3-5-8-19/h3-5,7-10,15,18H,11-14,16,27H2,1H3,(H2,28,34)/t18-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303588
PNG
(US10138229, Example 100)
Show SMILES CN(C)C\C=C\C(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C28H32N6O3/c1-32(2)14-6-9-23(35)33-17-28(18-33)15-20(16-28)34-26(29)24(27(30)36)25(31-34)19-10-12-22(13-11-19)37-21-7-4-3-5-8-21/h3-13,20H,14-18,29H2,1-2H3,(H2,30,36)/b9-6+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303585
PNG
(US10138229, Example 97)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2(CC(C2)NC(=O)C=C)C1
Show InChI InChI=1S/C26H27N5O3/c1-2-21(32)29-17-12-26(13-17)14-18(15-26)31-24(27)22(25(28)33)23(30-31)16-8-10-20(11-9-16)34-19-6-4-3-5-7-19/h2-11,17-18H,1,12-15,27H2,(H2,28,33)(H,29,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303598
PNG
(US10138229, Example 110)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cn2)C1
Show InChI InChI=1S/C25H24N6O3/c1-2-6-20(32)30-14-25(15-30)11-16(12-25)31-23(26)21(24(27)33)22(29-31)19-10-9-18(13-28-19)34-17-7-4-3-5-8-17/h3-5,7-10,13,16H,11-12,14-15,26H2,1H3,(H2,27,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303580
PNG
(US10138229, Example 92)
Show SMILES CC#CC(=O)N1CC[C@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C27H27N5O3/c1-2-6-22(33)31-14-13-27(17-31)15-19(16-27)32-25(28)23(26(29)34)24(30-32)18-9-11-21(12-10-18)35-20-7-4-3-5-8-20/h3-5,7-12,19H,13-17,28H2,1H3,(H2,29,34)/t19-,27+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303655
PNG
(US10138229, Example 167)
Show SMILES CCOc1ccc(cc1)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C23H27N5O3/c1-3-5-18(29)27-11-10-23(14-27)12-16(13-23)28-21(24)19(22(25)30)20(26-28)15-6-8-17(9-7-15)31-4-2/h6-9,16H,4,10-14,24H2,1-2H3,(H2,25,30)/t16-,23-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303628
PNG
(US10138229, Example 140)
Show SMILES CCCOc1ccc(cc1)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C24H29N5O3/c1-3-5-19(30)28-11-10-24(15-28)13-17(14-24)29-22(25)20(23(26)31)21(27-29)16-6-8-18(9-7-16)32-12-4-2/h6-9,17H,4,10-15,25H2,1-2H3,(H2,26,31)/t17-,24-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303616
PNG
(US10138229, Example 128)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(cc2)C(F)(F)F)C1
Show InChI InChI=1S/C22H22F3N5O2/c1-2-3-16(31)29-9-8-21(12-29)10-15(11-21)30-19(26)17(20(27)32)18(28-30)13-4-6-14(7-5-13)22(23,24)25/h4-7,15H,8-12,26H2,1H3,(H2,27,32)/t15-,21-
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n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303568
PNG
(US10138229, Example 80)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C26H27N5O3/c1-2-21(32)30-13-12-26(16-30)14-18(15-26)31-24(27)22(25(28)33)23(29-31)17-8-10-20(11-9-17)34-19-6-4-3-5-7-19/h2-11,18H,1,12-16,27H2,(H2,28,33)/t18-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303533
PNG
(US10138229, Example 44)
Show SMILES NC(=O)c1c(N)n(CCNC(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H21N5O3/c1-2-17(27)24-12-13-26-20(22)18(21(23)28)19(25-26)14-8-10-16(11-9-14)29-15-6-4-3-5-7-15/h2-11H,1,12-13,22H2,(H2,23,28)(H,24,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303605
PNG
(US10138229, Example 117)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cn1)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C25H26N6O3/c1-2-20(32)30-11-10-25(15-30)12-16(13-25)31-23(26)21(24(27)33)22(29-31)19-9-8-18(14-28-19)34-17-6-4-3-5-7-17/h2-9,14,16H,1,10-13,15,26H2,(H2,27,33)/t16-,25+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303547
PNG
(US10138229, Example 58)
Show SMILES CC#CC(=O)N1CC2(CC(C2)c2nc(c(s2)C(N)=O)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C26H23N3O3S/c1-2-6-21(30)29-15-26(16-29)13-18(14-26)25-28-22(23(33-25)24(27)31)17-9-11-20(12-10-17)32-19-7-4-3-5-8-19/h3-5,7-12,18H,13-16H2,1H3,(H2,27,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303649
PNG
(US10138229, Example 161)
Show SMILES CCCOc1ccc(cc1F)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C24H28FN5O3/c1-3-5-19(31)29-9-8-24(14-29)12-16(13-24)30-22(26)20(23(27)32)21(28-30)15-6-7-18(17(25)11-15)33-10-4-2/h6-7,11,16H,4,8-10,12-14,26H2,1-2H3,(H2,27,32)/t16-,24-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303656
PNG
(US10138229, Example 168)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(OC(C)C)cc2)C1
Show InChI InChI=1S/C24H29N5O3/c1-4-5-19(30)28-11-10-24(14-28)12-17(13-24)29-22(25)20(23(26)31)21(27-29)16-6-8-18(9-7-16)32-15(2)3/h6-9,15,17H,10-14,25H2,1-3H3,(H2,26,31)/t17-,24-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303535
PNG
(US10138229, Example 46)
Show SMILES NC(=O)c1[nH]c(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O3/c1-2-20(29)28-14-6-7-17(15-28)24-26-21(22(27-24)23(25)30)16-10-12-19(13-11-16)31-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,25,30)(H,26,27)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303648
PNG
(US10138229, Example 160)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(OC(F)(F)F)cc2)C1
Show InChI InChI=1S/C22H22F3N5O3/c1-2-3-16(31)29-9-8-21(12-29)10-14(11-21)30-19(26)17(20(27)32)18(28-30)13-4-6-15(7-5-13)33-22(23,24)25/h4-7,14H,8-12,26H2,1H3,(H2,27,32)/t14-,21-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303640
PNG
(US10138229, Example 152)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccn2)cc1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C25H26N6O3/c1-2-20(32)30-12-10-25(15-30)13-17(14-25)31-23(26)21(24(27)33)22(29-31)16-6-8-18(9-7-16)34-19-5-3-4-11-28-19/h2-9,11,17H,1,10,12-15,26H2,(H2,27,33)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303625
PNG
(US10138229, Example 137)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(F)c(OCC(F)(F)F)c2)C1
Show InChI InChI=1S/C23H23F4N5O3/c1-2-3-17(33)31-7-6-22(11-31)9-14(10-22)32-20(28)18(21(29)34)19(30-32)13-4-5-15(24)16(8-13)35-12-23(25,26)27/h4-5,8,14H,6-7,9-12,28H2,1H3,(H2,29,34)/t14-,22-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303540
PNG
(US10138229, Example 51)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23N3O3S/c1-2-20(28)27-14-6-7-17(15-27)24-26-21(22(31-24)23(25)29)16-10-12-19(13-11-16)30-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,25,29)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303620
PNG
(US10138229, Example 132)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OC2CCCC2)cc1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C25H31N5O3/c1-2-20(31)29-12-11-25(15-29)13-17(14-25)30-23(26)21(24(27)32)22(28-30)16-7-9-19(10-8-16)33-18-5-3-4-6-18/h2,7-10,17-18H,1,3-6,11-15,26H2,(H2,27,32)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303565
PNG
(US10138229, Example 77)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2(C1)CN(C2)C(=O)\C=C\CN1CCOCC1
Show InChI InChI=1S/C30H34N6O4/c31-28-26(29(32)38)27(21-8-10-24(11-9-21)40-23-5-2-1-3-6-23)33-36(28)22-17-30(18-22)19-35(20-30)25(37)7-4-12-34-13-15-39-16-14-34/h1-11,22H,12-20,31H2,(H2,32,38)/b7-4+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303645
PNG
(US10138229, Example 157)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(OC3CC3)cc2)C1
Show InChI InChI=1S/C24H27N5O3/c1-2-3-19(30)28-11-10-24(14-28)12-16(13-24)29-22(25)20(23(26)31)21(27-29)15-4-6-17(7-5-15)32-18-8-9-18/h4-7,16,18H,8-14,25H2,1H3,(H2,26,31)/t16-,24-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303570
PNG
(US10138229, Example 82)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2(C1)CCN(CC2)C(=O)C=C
Show InChI InChI=1S/C27H29N5O3/c1-2-22(33)31-14-12-27(13-15-31)16-19(17-27)32-25(28)23(26(29)34)24(30-32)18-8-10-21(11-9-18)35-20-6-4-3-5-7-20/h2-11,19H,1,12-17,28H2,(H2,29,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303571
PNG
(US10138229, Example 83)
Show SMILES CC#CC(=O)N1CCC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C28H29N5O3/c1-2-6-23(34)32-15-13-28(14-16-32)17-20(18-28)33-26(29)24(27(30)35)25(31-33)19-9-11-22(12-10-19)36-21-7-4-3-5-8-21/h3-5,7-12,20H,13-18,29H2,1H3,(H2,30,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303566
PNG
(US10138229, Example 78)
Show SMILES CC#CC(=O)N1CC[C@]2(C[C@@H](C2)c2nc(c(s2)C(N)=O)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C27H25N3O3S/c1-2-6-22(31)30-14-13-27(17-30)15-19(16-27)26-29-23(24(34-26)25(28)32)18-9-11-21(12-10-18)33-20-7-4-3-5-8-20/h3-5,7-12,19H,13-17H2,1H3,(H2,28,32)/t19-,27+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303626
PNG
(US10138229, Example 138)
Show SMILES CCCOc1ccc(cc1F)-c1nn(C2CC3(C2)CN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C23H26FN5O3/c1-3-5-18(30)28-12-23(13-28)10-15(11-23)29-21(25)19(22(26)31)20(27-29)14-6-7-17(16(24)9-14)32-8-4-2/h6-7,9,15H,4,8,10-13,25H2,1-2H3,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303641
PNG
(US10138229, Example 153)
Show SMILES COc1ccc(cc1)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C21H25N5O3/c1-3-16(27)25-9-8-21(12-25)10-14(11-21)26-19(22)17(20(23)28)18(24-26)13-4-6-15(29-2)7-5-13/h3-7,14H,1,8-12,22H2,2H3,(H2,23,28)/t14-,21-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303590
PNG
(US10138229, Example 102)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)nc2)C1
Show InChI InChI=1S/C25H24N6O3/c1-2-6-20(32)30-14-25(15-30)11-17(12-25)31-23(26)21(24(27)33)22(29-31)16-9-10-19(28-13-16)34-18-7-4-3-5-8-18/h3-5,7-10,13,17H,11-12,14-15,26H2,1H3,(H2,27,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303591
PNG
(US10138229, Example 103)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cn1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C24H24N6O3/c1-2-19(31)29-13-24(14-29)10-15(11-24)30-22(25)20(23(26)32)21(28-30)18-9-8-17(12-27-18)33-16-6-4-3-5-7-16/h2-9,12,15H,1,10-11,13-14,25H2,(H2,26,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303636
PNG
(BDBM303654 | US10138229, Example 148)
Show SMILES CCCOc1ccc(cc1Cl)-c1nn(C2CC3(C2)CN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C23H26ClN5O3/c1-3-5-18(30)28-12-23(13-28)10-15(11-23)29-21(25)19(22(26)31)20(27-29)14-6-7-17(16(24)9-14)32-8-4-2/h6-7,9,15H,4,8,10-13,25H2,1-2H3,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303539
PNG
(US10138229, Example 50)
Show SMILES NC(=O)c1sc(C[C@@H]2CCCN2C(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H23N3O3S/c1-2-21(28)27-14-6-7-17(27)15-20-26-22(23(31-20)24(25)29)16-10-12-19(13-11-16)30-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,25,29)/t17-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303515
PNG
(US10138229, Example 29)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O3/c1-2-22(29)27-14-6-7-18(15-27)28-16-21(24(25)30)23(26-28)17-10-12-20(13-11-17)31-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,25,30)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303546
PNG
(US10138229, Example 57)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C25H23N3O3S/c1-2-20(29)28-14-25(15-28)12-17(13-25)24-27-21(22(32-24)23(26)30)16-8-10-19(11-9-16)31-18-6-4-3-5-7-18/h2-11,17H,1,12-15H2,(H2,26,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303587
PNG
(US10138229, Example 99)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)\C=C\CN1CCOCC1
Show InChI InChI=1S/C31H36N6O4/c32-29-27(30(33)39)28(22-8-10-25(11-9-22)41-24-5-2-1-3-6-24)34-37(29)23-19-31(20-23)12-14-36(21-31)26(38)7-4-13-35-15-17-40-18-16-35/h1-11,23H,12-21,32H2,(H2,33,39)/b7-4+/t23-,31+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303595
PNG
(US10138229, Example 107)
Show SMILES CCCOc1ccc(cc1)-c1nn(C2CC3(C2)CN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C23H27N5O3/c1-3-5-18(29)27-13-23(14-27)11-16(12-23)28-21(24)19(22(25)30)20(26-28)15-6-8-17(9-7-15)31-10-4-2/h6-9,16H,4,10-14,24H2,1-2H3,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303602
PNG
(US10138229, Example 114)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)nc1)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C25H26N6O3/c1-2-20(32)30-11-10-25(15-30)12-17(13-25)31-23(26)21(24(27)33)22(29-31)16-8-9-19(28-14-16)34-18-6-4-3-5-7-18/h2-9,14,17H,1,10-13,15,26H2,(H2,27,33)/t17-,25+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303514
PNG
(US10138229, Example 28)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C25H24N4O3/c1-2-22(30)28-15-25(16-28)12-18(13-25)29-14-21(24(26)31)23(27-29)17-8-10-20(11-9-17)32-19-6-4-3-5-7-19/h2-11,14,18H,1,12-13,15-16H2,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303633
PNG
(US10138229, Example 145)
Show SMILES CCCOc1ccc(cc1Cl)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C24H28ClN5O3/c1-3-5-19(31)29-9-8-24(14-29)12-16(13-24)30-22(26)20(23(27)32)21(28-30)15-6-7-18(17(25)11-15)33-10-4-2/h6-7,11,16H,4,8-10,12-14,26H2,1-2H3,(H2,27,32)/t16-,24-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303608
PNG
(US10138229, Example 120)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cn1)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C25H26N6O3/c1-2-20(32)30-11-10-25(15-30)12-16(13-25)31-23(26)21(24(27)33)22(29-31)19-9-8-18(14-28-19)34-17-6-4-3-5-7-17/h2-9,14,16H,1,10-13,15,26H2,(H2,27,33)/t16-,25+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303603
PNG
(US10138229, Example 115)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(OCC(F)(F)F)cc2)C1
Show InChI InChI=1S/C22H22F3N5O3/c1-2-3-16(31)29-10-21(11-29)8-14(9-21)30-19(26)17(20(27)32)18(28-30)13-4-6-15(7-5-13)33-12-22(23,24)25/h4-7,14H,8-12,26H2,1H3,(H2,27,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303561
PNG
(US10138229, Example 72)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2nn(cc2C(N)=O)[C@@H]2CCCN(C2)C(=O)C=C)c1
Show InChI InChI=1S/C25H26N4O3/c1-3-23(30)28-13-5-7-19(15-28)29-16-22(25(26)31)24(27-29)18-9-11-20(12-10-18)32-21-8-4-6-17(2)14-21/h3-4,6,8-12,14,16,19H,1,5,7,13,15H2,2H3,(H2,26,31)/t19-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303575
PNG
(US10138229, Example 87)
Show SMILES CC#CC(=O)N1CCC2(CC(C2)c2nc(c([nH]2)C(N)=O)-c2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C28H28N4O3/c1-2-6-23(33)32-15-13-28(14-16-32)17-20(18-28)27-30-24(25(31-27)26(29)34)19-9-11-22(12-10-19)35-21-7-4-3-5-8-21/h3-5,7-12,20H,13-18H2,1H3,(H2,29,34)(H,30,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303601
PNG
(US10138229, Example 113)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OC2CC2)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C22H25N5O3/c1-2-17(28)26-11-22(12-26)9-14(10-22)27-20(23)18(21(24)29)19(25-27)13-3-5-15(6-4-13)30-16-7-8-16/h2-6,14,16H,1,7-12,23H2,(H2,24,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303584
PNG
(US10138229, Example 96)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2F)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23FN4O3/c1-2-22(30)28-13-5-6-17(14-28)29-15-19(24(26)31)23(27-29)16-9-11-18(12-10-16)32-21-8-4-3-7-20(21)25/h2-4,7-12,15,17H,1,5-6,13-14H2,(H2,26,31)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303651
PNG
(US10138229, Example 163)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OCC(F)(F)F)cc1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C22H24F3N5O3/c1-2-16(31)29-8-7-21(11-29)9-14(10-21)30-19(26)17(20(27)32)18(28-30)13-3-5-15(6-4-13)33-12-22(23,24)25/h2-6,14H,1,7-12,26H2,(H2,27,32)/t14-,21-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303527
PNG
(US10138229, Example 40)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C26H26N4O3/c1-2-23(31)29-13-12-26(17-29)14-19(15-26)30-16-22(25(27)32)24(28-30)18-8-10-21(11-9-18)33-20-6-4-3-5-7-20/h2-11,16,19H,1,12-15,17H2,(H2,27,32)/t19-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303511
PNG
(US10138229, Example 25)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1nn(cc1C(N)=O)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C29H30N6O4/c1-4-26(36)34-13-7-9-20(16-34)35-17-21(28(30)37)27(32-35)19-11-12-22(25(15-19)39-3)31-29(38)24-14-18-8-5-6-10-23(18)33(24)2/h4-6,8,10-12,14-15,17,20H,1,7,9,13,16H2,2-3H3,(H2,30,37)(H,31,38)/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303646
PNG
(BDBM303647 | US10138229, Example 158)
Show SMILES COc1ccc(-c2nn([C@H]3C[C@]4(C3)CCN(C4)C(=O)C#CC)c(N)c2C(N)=O)c(Cl)c1
Show InChI InChI=1S/C22H24ClN5O3/c1-3-4-17(29)27-8-7-22(12-27)10-13(11-22)28-20(24)18(21(25)30)19(26-28)15-6-5-14(31-2)9-16(15)23/h5-6,9,13H,7-8,10-12,24H2,1-2H3,(H2,25,30)/t13-,22-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303567
PNG
(US10138229, Example 79)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C26H25N3O3S/c1-2-21(30)29-13-12-26(16-29)14-18(15-26)25-28-22(23(33-25)24(27)31)17-8-10-20(11-9-17)32-19-6-4-3-5-7-19/h2-11,18H,1,12-16H2,(H2,27,31)/t18-,26+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303618
PNG
(US10138229, Example 130)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(cc1)C(F)(F)F)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C21H22F3N5O2/c1-2-15(30)28-8-7-20(11-28)9-14(10-20)29-18(25)16(19(26)31)17(27-29)12-3-5-13(6-4-12)21(22,23)24/h2-6,14H,1,7-11,25H2,(H2,26,31)/t14-,20-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303544
PNG
(US10138229, Example 55)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O3/c1-2-22(29)27-14-12-18(13-15-27)28-16-21(24(25)30)23(26-28)17-8-10-20(11-9-17)31-19-6-4-3-5-7-19/h2-11,16,18H,1,12-15H2,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303636
PNG
(BDBM303654 | US10138229, Example 148)
Show SMILES CCCOc1ccc(cc1Cl)-c1nn(C2CC3(C2)CN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C23H26ClN5O3/c1-3-5-18(30)28-12-23(13-28)10-15(11-23)29-21(25)19(22(26)31)20(27-29)14-6-7-17(16(24)9-14)32-8-4-2/h6-7,9,15H,4,8,10-13,25H2,1-2H3,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303600
PNG
(US10138229, Example 112)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OC2CC2)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C22H25N5O3/c1-2-17(28)26-11-22(12-26)9-14(10-22)27-20(23)18(21(24)29)19(25-27)13-3-5-15(6-4-13)30-16-7-8-16/h2-6,14,16H,1,7-12,23H2,(H2,24,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303643
PNG
(US10138229, Example 155)
Show SMILES COc1cccc(c1)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C21H25N5O3/c1-3-16(27)25-8-7-21(12-25)10-14(11-21)26-19(22)17(20(23)28)18(24-26)13-5-4-6-15(9-13)29-2/h3-6,9,14H,1,7-8,10-12,22H2,2H3,(H2,23,28)/t14-,21-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303613
PNG
(BDBM303614 | US10138229, Example 125)
Show SMILES CCCOc1ccc(cc1)-c1nn([C@H]2C[C@@]3(C2)CCN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C23H29N5O3/c1-3-11-31-17-7-5-15(6-8-17)20-19(22(25)30)21(24)28(26-20)16-12-23(13-16)9-10-27(14-23)18(29)4-2/h4-8,16H,2-3,9-14,24H2,1H3,(H2,25,30)/t16-,23+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303508
PNG
(US10138229, Example 22)
Show SMILES COc1cc(ccc1Oc1ccccc1)-c1nn(cc1C(N)=O)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H26N4O4/c1-3-23(30)28-13-7-8-18(15-28)29-16-20(25(26)31)24(27-29)17-11-12-21(22(14-17)32-2)33-19-9-5-4-6-10-19/h3-6,9-12,14,16,18H,1,7-8,13,15H2,2H3,(H2,26,31)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303621
PNG
(US10138229, Example 133)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(O)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C19H21N5O3/c1-2-14(26)23-9-19(10-23)7-12(8-19)24-17(20)15(18(21)27)16(22-24)11-3-5-13(25)6-4-11/h2-6,12,25H,1,7-10,20H2,(H2,21,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303548
PNG
(US10138229, Example 59)
Show SMILES CC#CC(=O)N1CCC[C@H](C1)c1nc(c([nH]1)C(N)=O)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H24N4O3/c1-2-7-21(30)29-15-6-8-18(16-29)25-27-22(23(28-25)24(26)31)17-11-13-20(14-12-17)32-19-9-4-3-5-10-19/h3-5,9-14,18H,6,8,15-16H2,1H3,(H2,26,31)(H,27,28)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303611
PNG
(US10138229, Example 123)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)nc1)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C25H26N6O3/c1-2-20(32)30-11-10-25(15-30)12-17(13-25)31-23(26)21(24(27)33)22(29-31)16-8-9-19(28-14-16)34-18-6-4-3-5-7-18/h2-9,14,17H,1,10-13,15,26H2,(H2,27,33)/t17-,25+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303635
PNG
(US10138229, Example 147)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(cc2)C(F)(F)F)C1
Show InChI InChI=1S/C21H20F3N5O2/c1-2-3-15(30)28-10-20(11-28)8-14(9-20)29-18(25)16(19(26)31)17(27-29)12-4-6-13(7-5-12)21(22,23)24/h4-7,14H,8-11,25H2,1H3,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303589
PNG
(US10138229, Example 101)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)nc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C24H24N6O3/c1-2-19(31)29-13-24(14-29)10-16(11-24)30-22(25)20(23(26)32)21(28-30)15-8-9-18(27-12-15)33-17-6-4-3-5-7-17/h2-9,12,16H,1,10-11,13-14,25H2,(H2,26,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303650
PNG
(US10138229, Example 162)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OC(F)(F)F)cc1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C21H22F3N5O3/c1-2-15(30)28-8-7-20(11-28)9-13(10-20)29-18(25)16(19(26)31)17(27-29)12-3-5-14(6-4-12)32-21(22,23)24/h2-6,13H,1,7-11,25H2,(H2,26,31)/t13-,20-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303562
PNG
(US10138229, Example 73)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23FN4O3/c1-2-22(30)28-12-4-6-18(14-28)29-15-21(24(26)31)23(27-29)16-8-10-19(11-9-16)32-20-7-3-5-17(25)13-20/h2-3,5,7-11,13,15,18H,1,4,6,12,14H2,(H2,26,31)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303510
PNG
(US10138229, Example 24)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)c(Cl)c1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23ClN4O3/c1-2-22(30)28-12-6-7-17(14-28)29-15-19(24(26)31)23(27-29)16-10-11-21(20(25)13-16)32-18-8-4-3-5-9-18/h2-5,8-11,13,15,17H,1,6-7,12,14H2,(H2,26,31)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303519
PNG
(US10138229, Example 33)
Show SMILES NC(=O)c1cn(C[C@@H]2CCCN2C(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H24N4O3/c1-2-22(29)28-14-6-7-18(28)15-27-16-21(24(25)30)23(26-27)17-10-12-20(13-11-17)31-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,25,30)/t18-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303509
PNG
(US10138229, Example 23)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)c(F)c1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23FN4O3/c1-2-22(30)28-12-6-7-17(14-28)29-15-19(24(26)31)23(27-29)16-10-11-21(20(25)13-16)32-18-8-4-3-5-9-18/h2-5,8-11,13,15,17H,1,6-7,12,14H2,(H2,26,31)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303536
PNG
(US10138229, Example 47)
Show SMILES NC(=O)c1cn(CC2CCN(CC2)C(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O3/c1-2-23(30)28-14-12-18(13-15-28)16-29-17-22(25(26)31)24(27-29)19-8-10-21(11-9-19)32-20-6-4-3-5-7-20/h2-11,17-18H,1,12-16H2,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303534
PNG
(US10138229, Example 45)
Show SMILES NC(=O)c1cn(CC2CCCN(C2)C(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O3/c1-2-23(30)28-14-6-7-18(15-28)16-29-17-22(25(26)31)24(27-29)19-10-12-21(13-11-19)32-20-8-4-3-5-9-20/h2-5,8-13,17-18H,1,6-7,14-16H2,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303612
PNG
(US10138229, Example 124)
Show SMILES CC(C)Oc1ccc(cc1Cl)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C22H26ClN5O3/c1-4-17(29)27-10-22(11-27)8-14(9-22)28-20(24)18(21(25)30)19(26-28)13-5-6-16(15(23)7-13)31-12(2)3/h4-7,12,14H,1,8-11,24H2,2-3H3,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303606
PNG
(US10138229, Example 118 | US10138229, Example 119)
Show SMILES CC#CC(=O)N1CC[C@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)cn2)C1
Show InChI InChI=1S/C26H26N6O3/c1-2-6-21(33)31-12-11-26(16-31)13-17(14-26)32-24(27)22(25(28)34)23(30-32)20-10-9-19(15-29-20)35-18-7-4-3-5-8-18/h3-5,7-10,15,17H,11-14,16,27H2,1H3,(H2,28,34)/t17-,26+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303604
PNG
(US10138229, Example 116)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OCC(F)(F)F)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C21H22F3N5O3/c1-2-15(30)28-9-20(10-28)7-13(8-20)29-18(25)16(19(26)31)17(27-29)12-3-5-14(6-4-12)32-11-21(22,23)24/h2-6,13H,1,7-11,25H2,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303594
PNG
(US10138229, Example 106)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(OC(C)C)cc2)C1
Show InChI InChI=1S/C23H27N5O3/c1-4-5-18(29)27-12-23(13-27)10-16(11-23)28-21(24)19(22(25)30)20(26-28)15-6-8-17(9-7-15)31-14(2)3/h6-9,14,16H,10-13,24H2,1-3H3,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303593
PNG
(US10138229, Example 105)
Show SMILES CC(C)Oc1ccc(cc1)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C22H27N5O3/c1-4-17(28)26-11-22(12-26)9-15(10-22)27-20(23)18(21(24)29)19(25-27)14-5-7-16(8-6-14)30-13(2)3/h4-8,13,15H,1,9-12,23H2,2-3H3,(H2,24,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303524
PNG
(US10138229, Example 38)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2cc(C(N)=O)c(n2)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C27H26N4O3/c1-2-6-24(32)30-14-13-27(18-30)15-20(16-27)31-17-23(26(28)33)25(29-31)19-9-11-22(12-10-19)34-21-7-4-3-5-8-21/h3-5,7-12,17,20H,13-16,18H2,1H3,(H2,28,33)/t20-,27-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303596
PNG
(US10138229, Example 108)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(OC(F)(F)F)cc2)C1
Show InChI InChI=1S/C21H20F3N5O3/c1-2-3-15(30)28-10-20(11-28)8-13(9-20)29-18(25)16(19(26)31)17(27-29)12-4-6-14(7-5-12)32-21(22,23)24/h4-7,13H,8-11,25H2,1H3,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303560
PNG
(US10138229, Example 71)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(cc2C(N)=O)[C@@H]2CCCN(C2)C(=O)C=C)cc1
Show InChI InChI=1S/C25H26N4O3/c1-3-23(30)28-14-4-5-19(15-28)29-16-22(25(26)31)24(27-29)18-8-12-21(13-9-18)32-20-10-6-17(2)7-11-20/h3,6-13,16,19H,1,4-5,14-15H2,2H3,(H2,26,31)/t19-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303629
PNG
(US10138229, Example 141)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(c(F)c2)C(F)(F)F)C1
Show InChI InChI=1S/C21H19F4N5O2/c1-2-3-15(31)29-9-20(10-29)7-12(8-20)30-18(26)16(19(27)32)17(28-30)11-4-5-13(14(22)6-11)21(23,24)25/h4-6,12H,7-10,26H2,1H3,(H2,27,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303501
PNG
(US10138229, Example 9)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Cc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H26N4O2/c1-2-23(30)28-14-6-9-21(16-28)29-17-22(25(26)31)24(27-29)20-12-10-19(11-13-20)15-18-7-4-3-5-8-18/h2-5,7-8,10-13,17,21H,1,6,9,14-16H2,(H2,26,31)/t21-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303542
PNG
(US10138229, Example 53)
Show SMILES CC#CC(=O)N1CCC[C@H]1Cc1nc(c(s1)C(N)=O)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H23N3O3S/c1-2-7-22(29)28-15-6-8-18(28)16-21-27-23(24(32-21)25(26)30)17-11-13-20(14-12-17)31-19-9-4-3-5-10-19/h3-5,9-14,18H,6,8,15-16H2,1H3,(H2,26,30)/t18-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303624
PNG
(US10138229, Example 136)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(Cl)c(c2)C(F)(F)F)C1
Show InChI InChI=1S/C21H19ClF3N5O2/c1-2-3-15(31)29-9-20(10-29)7-12(8-20)30-18(26)16(19(27)32)17(28-30)11-4-5-14(22)13(6-11)21(23,24)25/h4-6,12H,7-10,26H2,1H3,(H2,27,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303653
PNG
(US10138229, Example 165)
Show SMILES CCCOc1ccc(cc1F)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C23H28FN5O3/c1-3-9-32-17-6-5-14(10-16(17)24)20-19(22(26)31)21(25)29(27-20)15-11-23(12-15)7-8-28(13-23)18(30)4-2/h4-6,10,15H,2-3,7-9,11-13,25H2,1H3,(H2,26,31)/t15-,23-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303615
PNG
(US10138229, Example 127)
Show SMILES CCCOc1ccc(cc1)-c1nn([C@H]2C[C@@]3(C2)CCN(C3)C(=O)C#CC)c(N)c1C(N)=O
Show InChI InChI=1S/C24H29N5O3/c1-3-5-19(30)28-11-10-24(15-28)13-17(14-24)29-22(25)20(23(26)31)21(27-29)16-6-8-18(9-7-16)32-12-4-2/h6-9,17H,4,10-15,25H2,1-2H3,(H2,26,31)/t17-,24+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303545
PNG
(US10138229, Example 56)
Show SMILES CC#CC(=O)N1CCC(CC1)n1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H24N4O3/c1-2-6-23(30)28-15-13-19(14-16-28)29-17-22(25(26)31)24(27-29)18-9-11-21(12-10-18)32-20-7-4-3-5-8-20/h3-5,7-12,17,19H,13-16H2,1H3,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303599
PNG
(US10138229, Example 111)
Show SMILES CCCOc1ccc(cc1)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C22H27N5O3/c1-3-9-30-16-7-5-14(6-8-16)19-18(21(24)29)20(23)27(25-19)15-10-22(11-15)12-26(13-22)17(28)4-2/h4-8,15H,2-3,9-13,23H2,1H3,(H2,24,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303627
PNG
(US10138229, Example 139)
Show SMILES CCCOc1ccc(cc1F)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C22H26FN5O3/c1-3-7-31-16-6-5-13(8-15(16)23)19-18(21(25)30)20(24)28(26-19)14-9-22(10-14)11-27(12-22)17(29)4-2/h4-6,8,14H,2-3,7,9-12,24H2,1H3,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303644
PNG
(US10138229, Example 156)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OC2CC2)cc1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C23H27N5O3/c1-2-18(29)27-10-9-23(13-27)11-15(12-23)28-21(24)19(22(25)30)20(26-28)14-3-5-16(6-4-14)31-17-7-8-17/h2-6,15,17H,1,7-13,24H2,(H2,25,30)/t15-,23-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303610
PNG
(US10138229, Example 122)
Show SMILES CC#CC(=O)N1CC[C@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(Oc3ccccc3)nc2)C1
Show InChI InChI=1S/C26H26N6O3/c1-2-6-21(33)31-12-11-26(16-31)13-18(14-26)32-24(27)22(25(28)34)23(30-32)17-9-10-20(29-15-17)35-19-7-4-3-5-8-19/h3-5,7-10,15,18H,11-14,16,27H2,1H3,(H2,28,34)/t18-,26+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303541
PNG
(US10138229, Example 52)
Show SMILES CC#CC(=O)N1CCC[C@H](C1)c1nc(c(s1)C(N)=O)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H23N3O3S/c1-2-7-21(29)28-15-6-8-18(16-28)25-27-22(23(32-25)24(26)30)17-11-13-20(14-12-17)31-19-9-4-3-5-10-19/h3-5,9-14,18H,6,8,15-16H2,1H3,(H2,26,30)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303592
PNG
(US10138229, Example 104)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OCC2CC2)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C23H27N5O3/c1-2-18(29)27-12-23(13-27)9-16(10-23)28-21(24)19(22(25)30)20(26-28)15-5-7-17(8-6-15)31-11-14-3-4-14/h2,5-8,14,16H,1,3-4,9-13,24H2,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303646
PNG
(BDBM303647 | US10138229, Example 158)
Show SMILES COc1ccc(-c2nn([C@H]3C[C@]4(C3)CCN(C4)C(=O)C#CC)c(N)c2C(N)=O)c(Cl)c1
Show InChI InChI=1S/C22H24ClN5O3/c1-3-4-17(29)27-8-7-22(12-27)10-13(11-22)28-20(24)18(21(25)30)19(26-28)15-6-5-14(31-2)9-16(15)23/h5-6,9,13H,7-8,10-12,24H2,1-2H3,(H2,25,30)/t13-,22-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303520
PNG
(US10138229, Example 34)
Show SMILES NC(=O)c1sc(CCNC(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O3S/c1-2-17(25)23-13-12-18-24-19(20(28-18)21(22)26)14-8-10-16(11-9-14)27-15-6-4-3-5-7-15/h2-11H,1,12-13H2,(H2,22,26)(H,23,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303576
PNG
(US10138229, Example 88)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C26H26N4O3/c1-2-23(31)29-13-12-26(17-29)14-19(15-26)30-16-22(25(27)32)24(28-30)18-8-10-21(11-9-18)33-20-6-4-3-5-7-20/h2-11,16,19H,1,12-15,17H2,(H2,27,32)/t19-,26+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303512
PNG
(US10138229, Example 26)
Show SMILES COc1cc(ccc1NC(=O)c1ccc(cc1F)C(F)(F)F)-c1nn(cc1C(N)=O)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C27H25F4N5O4/c1-3-23(37)35-10-4-5-17(13-35)36-14-19(25(32)38)24(34-36)15-6-9-21(22(11-15)40-2)33-26(39)18-8-7-16(12-20(18)28)27(29,30)31/h3,6-9,11-12,14,17H,1,4-5,10,13H2,2H3,(H2,32,38)(H,33,39)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303634
PNG
(US10138229, Example 146)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(F)c(OCC(F)(F)F)c1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C22H23F4N5O3/c1-2-16(32)30-6-5-21(10-30)8-13(9-21)31-19(27)17(20(28)33)18(29-31)12-3-4-14(23)15(7-12)34-11-22(24,25)26/h2-4,7,13H,1,5-6,8-11,27H2,(H2,28,33)/t13-,21-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303597
PNG
(US10138229, Example 109)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OC(F)(F)F)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C20H20F3N5O3/c1-2-14(29)27-9-19(10-27)7-12(8-19)28-17(24)15(18(25)30)16(26-28)11-3-5-13(6-4-11)31-20(21,22)23/h2-6,12H,1,7-10,24H2,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303623
PNG
(US10138229, Example 135)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cl)c(c1)C(F)(F)F)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C20H19ClF3N5O2/c1-2-14(30)28-8-19(9-28)6-11(7-19)29-17(25)15(18(26)31)16(27-29)10-3-4-13(21)12(5-10)20(22,23)24/h2-5,11H,1,6-9,25H2,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303619
PNG
(US10138229, Example 131)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(cc1)C(F)(F)F)[C@H]1C[C@@]2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C21H22F3N5O2/c1-2-15(30)28-8-7-20(11-28)9-14(10-20)29-18(25)16(19(26)31)17(27-29)12-3-5-13(6-4-12)21(22,23)24/h2-6,14H,1,7-11,25H2,(H2,26,31)/t14-,20+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303613
PNG
(BDBM303614 | US10138229, Example 125)
Show SMILES CCCOc1ccc(cc1)-c1nn([C@H]2C[C@@]3(C2)CCN(C3)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C23H29N5O3/c1-3-11-31-17-7-5-15(6-8-17)20-19(22(25)30)21(24)28(26-20)16-12-23(13-16)9-10-27(14-23)18(29)4-2/h4-8,16H,2-3,9-14,24H2,1H3,(H2,25,30)/t16-,23+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303630
PNG
(US10138229, Example 142)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(c(F)c1)C(F)(F)F)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C20H19F4N5O2/c1-2-14(30)28-8-19(9-28)6-11(7-19)29-17(25)15(18(26)31)16(27-29)10-3-4-12(13(21)5-10)20(22,23)24/h2-5,11H,1,6-9,25H2,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303617
PNG
(US10138229, Example 129)
Show SMILES CC#CC(=O)N1CC[C@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(cc2)C(F)(F)F)C1
Show InChI InChI=1S/C22H22F3N5O2/c1-2-3-16(31)29-9-8-21(12-29)10-15(11-21)30-19(26)17(20(27)32)18(28-30)13-4-6-14(7-5-13)22(23,24)25/h4-7,15H,8-12,26H2,1H3,(H2,27,32)/t15-,21+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303506
PNG
(US10138229, Example 20)
Show SMILES COc1cc(ccc1Oc1ccc(Cl)c(Cl)c1)-c1nn(cc1C(N)=O)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24Cl2N4O4/c1-3-23(32)30-10-4-5-16(13-30)31-14-18(25(28)33)24(29-31)15-6-9-21(22(11-15)34-2)35-17-7-8-19(26)20(27)12-17/h3,6-9,11-12,14,16H,1,4-5,10,13H2,2H3,(H2,28,33)/t16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303581
PNG
(US10138229, Example 93)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C#CCN1CCOCC1
Show InChI InChI=1S/C29H31N5O4/c30-29(36)26-21-34(31-28(26)22-10-12-25(13-11-22)38-24-7-2-1-3-8-24)23-6-4-15-33(20-23)27(35)9-5-14-32-16-18-37-19-17-32/h1-3,7-8,10-13,21,23H,4,6,14-20H2,(H2,30,36)/t23-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303499
PNG
(US10138229, Example 2)
Show SMILES NC(=O)c1cn(nc1-c1ccc(OCc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H26N4O3/c1-2-23(30)28-14-6-9-20(15-28)29-16-22(25(26)31)24(27-29)19-10-12-21(13-11-19)32-17-18-7-4-3-5-8-18/h2-5,7-8,10-13,16,20H,1,6,9,14-15,17H2,(H2,26,31)/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303577
PNG
(US10138229, Example 89)
Show SMILES CC#CC(=O)N1CC[C@]2(C[C@@H](C2)n2cc(C(N)=O)c(n2)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C27H26N4O3/c1-2-6-24(32)30-14-13-27(18-30)15-20(16-27)31-17-23(26(28)33)25(29-31)19-9-11-22(12-10-19)34-21-7-4-3-5-8-21/h3-5,7-12,17,20H,13-16,18H2,1H3,(H2,28,33)/t20-,27+
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303631
PNG
(US10138229, Example 143)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(F)c(c2)C(F)(F)F)C1
Show InChI InChI=1S/C21H19F4N5O2/c1-2-3-15(31)29-9-20(10-29)7-12(8-20)30-18(26)16(19(27)32)17(28-30)11-4-5-14(22)13(6-11)21(23,24)25/h4-6,12H,7-10,26H2,1H3,(H2,27,32)
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n/an/a 37n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303523
PNG
(US10138229, Example 37)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@@]2(C[C@@H](C2)n2cc(C(N)=O)c(n2)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C29H33N5O3/c1-32(2)15-6-9-26(35)33-16-14-29(20-33)17-22(18-29)34-19-25(28(30)36)27(31-34)21-10-12-24(13-11-21)37-23-7-4-3-5-8-23/h3-13,19,22H,14-18,20H2,1-2H3,(H2,30,36)/b9-6+/t22-,29-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303556
PNG
(US10138229, Example 67)
Show SMILES COc1ccc(Oc2ccc(cc2)-c2nn(cc2C(N)=O)[C@@H]2CCCN(C2)C(=O)C=C)cc1
Show InChI InChI=1S/C25H26N4O4/c1-3-23(30)28-14-4-5-18(15-28)29-16-22(25(26)31)24(27-29)17-6-8-20(9-7-17)33-21-12-10-19(32-2)11-13-21/h3,6-13,16,18H,1,4-5,14-15H2,2H3,(H2,26,31)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303557
PNG
(US10138229, Example 68)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2cccc(Cl)c2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23ClN4O3/c1-2-22(30)28-12-4-6-18(14-28)29-15-21(24(26)31)23(27-29)16-8-10-19(11-9-16)32-20-7-3-5-17(25)13-20/h2-3,5,7-11,13,15,18H,1,4,6,12,14H2,(H2,26,31)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303549
PNG
(US10138229, Example 60)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2nn(cc2C(N)=O)[C@@H]2CCCN(C2)C(=O)C=C)c1
Show InChI InChI=1S/C26H28N6O3/c1-3-23(33)31-13-5-8-21(15-31)32-16-22(25(27)34)24(30-32)18-9-11-19(12-10-18)28-26(35)29-20-7-4-6-17(2)14-20/h3-4,6-7,9-12,14,16,21H,1,5,8,13,15H2,2H3,(H2,27,34)(H2,28,29,35)/t21-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303558
PNG
(US10138229, Example 69)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccc(Cl)c(Cl)c2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H22Cl2N4O3/c1-2-22(31)29-11-3-4-16(13-29)30-14-19(24(27)32)23(28-30)15-5-7-17(8-6-15)33-18-9-10-20(25)21(26)12-18/h2,5-10,12,14,16H,1,3-4,11,13H2,(H2,27,32)/t16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303555
PNG
(US10138229, Example 66)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccc(Cl)c(F)c2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H22ClFN4O3/c1-2-22(31)29-11-3-4-16(13-29)30-14-19(24(27)32)23(28-30)15-5-7-17(8-6-15)33-18-9-10-20(25)21(26)12-18/h2,5-10,12,14,16H,1,3-4,11,13H2,(H2,27,32)/t16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303559
PNG
(US10138229, Example 70)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23ClN4O3/c1-2-22(30)28-13-3-4-18(14-28)29-15-21(24(26)31)23(27-29)16-5-9-19(10-6-16)32-20-11-7-17(25)8-12-20/h2,5-12,15,18H,1,3-4,13-14H2,(H2,26,31)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303530
PNG
(US10138229, Example 43)
Show SMILES CC#CC(=O)N1CCC(Cn2cc(C(N)=O)c(n2)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C25H24N4O3/c1-2-6-23(30)28-14-13-18(15-28)16-29-17-22(25(26)31)24(27-29)19-9-11-21(12-10-19)32-20-7-4-3-5-8-20/h3-5,7-12,17-18H,13-16H2,1H3,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303572
PNG
(US10138229, Example 84)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2(C1)CCN(CC2)C(=O)C=C
Show InChI InChI=1S/C27H27N3O3S/c1-2-22(31)30-14-12-27(13-15-30)16-19(17-27)26-29-23(24(34-26)25(28)32)18-8-10-21(11-9-18)33-20-6-4-3-5-7-20/h2-11,19H,1,12-17H2,(H2,28,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303516
PNG
(US10138229, Example 30)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H31N5O3/c1-30(2)16-7-11-25(33)31-17-6-8-21(18-31)32-19-24(27(28)34)26(29-32)20-12-14-23(15-13-20)35-22-9-4-3-5-10-22/h3-5,7,9-15,19,21H,6,8,16-18H2,1-2H3,(H2,28,34)/b11-7+/t21-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303564
PNG
(US10138229, Example 76)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2cccc(c2)C#N)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23N5O3/c1-2-23(31)29-12-4-6-19(15-29)30-16-22(25(27)32)24(28-30)18-8-10-20(11-9-18)33-21-7-3-5-17(13-21)14-26/h2-3,5,7-11,13,16,19H,1,4,6,12,15H2,(H2,27,32)/t19-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303529
PNG
(US10138229, Example 42)
Show SMILES NC(=O)c1cn(CC2CCN(C2)C(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H24N4O3/c1-2-22(29)27-13-12-17(14-27)15-28-16-21(24(25)30)23(26-28)18-8-10-20(11-9-18)31-19-6-4-3-5-7-19/h2-11,16-17H,1,12-15H2,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303632
PNG
(US10138229, Example 144)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(F)c(c1)C(F)(F)F)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C20H19F4N5O2/c1-2-14(30)28-8-19(9-28)6-11(7-19)29-17(25)15(18(26)31)16(27-29)10-3-4-13(21)12(5-10)20(22,23)24/h2-5,11H,1,6-9,25H2,(H2,26,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303517
PNG
(US10138229, Example 31)
Show SMILES CC#CC(=O)N1CCC[C@H](C1)n1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H24N4O3/c1-2-7-23(30)28-15-6-8-19(16-28)29-17-22(25(26)31)24(27-29)18-11-13-21(14-12-18)32-20-9-4-3-5-10-20/h3-5,9-14,17,19H,6,8,15-16H2,1H3,(H2,26,31)/t19-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303537
PNG
(US10138229, Example 48)
Show SMILES CC#CC(=O)N1CCCC(Cn2cc(C(N)=O)c(n2)-c2ccc(Oc3ccccc3)cc2)C1
Show InChI InChI=1S/C26H26N4O3/c1-2-7-24(31)29-15-6-8-19(16-29)17-30-18-23(26(27)32)25(28-30)20-11-13-22(14-12-20)33-21-9-4-3-5-10-21/h3-5,9-14,18-19H,6,8,15-17H2,1H3,(H2,27,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303578
PNG
(US10138229, Example 90)
Show SMILES CNC(=O)\C=C\CN1CCC[C@H](C1)n1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H29N5O3/c1-28-24(32)10-6-16-30-15-5-7-20(17-30)31-18-23(26(27)33)25(29-31)19-11-13-22(14-12-19)34-21-8-3-2-4-9-21/h2-4,6,8-14,18,20H,5,7,15-17H2,1H3,(H2,27,33)(H,28,32)/b10-6+/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303551
PNG
(US10138229, Example 62)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23FN4O3/c1-2-22(30)28-13-3-4-18(14-28)29-15-21(24(26)31)23(27-29)16-5-9-19(10-6-16)32-20-11-7-17(25)8-12-20/h2,5-12,15,18H,1,3-4,13-14H2,(H2,26,31)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303574
PNG
(US10138229, Example 86)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2(C1)CCN(CC2)C(=O)C=C
Show InChI InChI=1S/C27H28N4O3/c1-2-24(32)30-14-12-27(13-15-30)16-20(17-27)31-18-23(26(28)33)25(29-31)19-8-10-22(11-9-19)34-21-6-4-3-5-7-21/h2-11,18,20H,1,12-17H2,(H2,28,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303507
PNG
(US10138229, Example 21)
Show SMILES NC(=O)c1cn(nc1-c1ccc(OCc2ccccn2)c(Cl)c1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H24ClN5O3/c1-2-22(31)29-11-5-7-18(13-29)30-14-19(24(26)32)23(28-30)16-8-9-21(20(25)12-16)33-15-17-6-3-4-10-27-17/h2-4,6,8-10,12,14,18H,1,5,7,11,13,15H2,(H2,26,32)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303637
PNG
(US10138229, Example 149)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(c(C(N)=O)c2N)-c2ccc(F)c(OCC(F)(F)F)c2)C1
Show InChI InChI=1S/C22H21F4N5O3/c1-2-3-16(32)30-9-21(10-30)7-13(8-21)31-19(27)17(20(28)33)18(29-31)12-4-5-14(23)15(6-12)34-11-22(24,25)26/h4-6,13H,7-11,27H2,1H3,(H2,28,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303622
PNG
(US10138229, Example 134)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(OC2CCOC2)cc1)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C23H27N5O4/c1-2-18(29)27-12-23(13-27)9-15(10-23)28-21(24)19(22(25)30)20(26-28)14-3-5-16(6-4-14)32-17-7-8-31-11-17/h2-6,15,17H,1,7-13,24H2,(H2,25,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303518
PNG
(US10138229, Example 32)
Show SMILES CC#CC(=O)N1CCC[C@H]1Cn1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H24N4O3/c1-2-7-23(30)29-15-6-8-19(29)16-28-17-22(25(26)31)24(27-28)18-11-13-21(14-12-18)32-20-9-4-3-5-10-20/h3-5,9-14,17,19H,6,8,15-16H2,1H3,(H2,26,31)/t19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303538
PNG
(US10138229, Example 49)
Show SMILES CC#CC(=O)N1CCC(Cn2cc(C(N)=O)c(n2)-c2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C26H26N4O3/c1-2-6-24(31)29-15-13-19(14-16-29)17-30-18-23(26(27)32)25(28-30)20-9-11-22(12-10-20)33-21-7-4-3-5-8-21/h3-5,7-12,18-19H,13-17H2,1H3,(H2,27,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303522
PNG
(US10138229, Example 36)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H]1Cn1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H31N5O3/c1-30(2)16-7-11-25(33)32-17-6-8-21(32)18-31-19-24(27(28)34)26(29-31)20-12-14-23(15-13-20)35-22-9-4-3-5-10-22/h3-5,7,9-15,19,21H,6,8,16-18H2,1-2H3,(H2,28,34)/b11-7+/t21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303526
PNG
(US10138229, Example 39)
Show SMILES NC(=O)c1cn(CCNC(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H20N4O3/c1-2-19(26)23-12-13-25-14-18(21(22)27)20(24-25)15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h2-11,14H,1,12-13H2,(H2,22,27)(H,23,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303513
PNG
(US10138229, Example 27)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Nc2nc3ccccc3o2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O3/c1-2-22(32)30-13-5-6-18(14-30)31-15-19(24(26)33)23(29-31)16-9-11-17(12-10-16)27-25-28-20-7-3-4-8-21(20)34-25/h2-4,7-12,15,18H,1,5-6,13-14H2,(H2,26,33)(H,27,28)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303573
PNG
(US10138229, Example 85)
Show SMILES CC#CC(=O)N1CCC2(CC(C2)c2nc(c(s2)C(N)=O)-c2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C28H27N3O3S/c1-2-6-23(32)31-15-13-28(14-16-31)17-20(18-28)27-30-24(25(35-27)26(29)33)19-9-11-22(12-10-19)34-21-7-4-3-5-8-21/h3-5,7-12,20H,13-18H2,1H3,(H2,29,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303554
PNG
(US10138229, Example 65)
Show SMILES CS(=O)(=O)c1cccc(Oc2ccc(cc2)-c2nn(cc2C(N)=O)[C@@H]2CCCN(C2)C(=O)C=C)c1
Show InChI InChI=1S/C25H26N4O5S/c1-3-23(30)28-13-5-6-18(15-28)29-16-22(25(26)31)24(27-29)17-9-11-19(12-10-17)34-20-7-4-8-21(14-20)35(2,32)33/h3-4,7-12,14,16,18H,1,5-6,13,15H2,2H3,(H2,26,31)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303504
PNG
(US10138229, Example 16)
Show SMILES NC(=O)c1cn(nc1-c1ccc2occc2c1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C20H20N4O3/c1-2-18(25)23-8-3-4-15(11-23)24-12-16(20(21)26)19(22-24)14-5-6-17-13(10-14)7-9-27-17/h2,5-7,9-10,12,15H,1,3-4,8,11H2,(H2,21,26)/t15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303552
PNG
(US10138229, Example 63)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23F3N4O3/c1-2-22(33)31-13-3-4-18(14-31)32-15-21(24(29)34)23(30-32)16-5-9-19(10-6-16)35-20-11-7-17(8-12-20)25(26,27)28/h2,5-12,15,18H,1,3-4,13-14H2,(H2,29,34)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303550
PNG
(US10138229, Example 61)
Show SMILES NC(=O)c1cn(nc1-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23Cl2N5O4S/c1-2-21(32)30-12-4-5-17(13-30)31-14-18(24(27)33)23(28-31)15-8-10-16(11-9-15)29-36(34,35)20-7-3-6-19(25)22(20)26/h2-3,6-11,14,17,29H,1,4-5,12-13H2,(H2,27,33)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303500
PNG
(US10138229, Example 3)
Show SMILES NC(=O)c1cn(nc1-c1cccc(OCc2ccccc2)c1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H26N4O3/c1-2-23(30)28-13-7-11-20(15-28)29-16-22(25(26)31)24(27-29)19-10-6-12-21(14-19)32-17-18-8-4-3-5-9-18/h2-6,8-10,12,14,16,20H,1,7,11,13,15,17H2,(H2,26,31)/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303583
PNG
(US10138229, Example 95)
Show SMILES COCCOc1ccc(cc1)-c1nn(cc1C(N)=O)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C21H26N4O4/c1-3-19(26)24-10-4-5-16(13-24)25-14-18(21(22)27)20(23-25)15-6-8-17(9-7-15)29-12-11-28-2/h3,6-9,14,16H,1,4-5,10-13H2,2H3,(H2,22,27)/t16-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303495
PNG
(US10138229, Example 1)
Show SMILES NC(=O)c1cn(nc1-c1ccc(cc1)-c1ccccc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O2/c1-2-22(29)27-14-6-9-20(15-27)28-16-21(24(25)30)23(26-28)19-12-10-18(11-13-19)17-7-4-3-5-8-17/h2-5,7-8,10-13,16,20H,1,6,9,14-15H2,(H2,25,30)/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303505
PNG
(US10138229, Example 17)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1nn(cc1C(N)=O)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C19H23N5O4S/c1-3-17(25)23-9-5-8-15(11-23)24-12-16(19(20)26)18(21-24)13-6-4-7-14(10-13)22-29(2,27)28/h3-4,6-7,10,12,15,22H,1,5,8-9,11H2,2H3,(H2,20,26)/t15-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303502
PNG
(US10138229, Example 11)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)-c1nn(cc1C(N)=O)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H27N5O4S/c1-3-23(31)29-13-5-8-20(15-29)30-16-22(25(26)32)24(27-30)18-6-4-7-19(14-18)28-35(33,34)21-11-9-17(2)10-12-21/h3-4,6-7,9-12,14,16,20,28H,1,5,8,13,15H2,2H3,(H2,26,32)/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303553
PNG
(US10138229, Example 64)
Show SMILES CS(=O)(=O)c1ccc(Oc2ccc(cc2)-c2nn(cc2C(N)=O)[C@@H]2CCCN(C2)C(=O)C=C)cc1
Show InChI InChI=1S/C25H26N4O5S/c1-3-23(30)28-14-4-5-18(15-28)29-16-22(25(26)31)24(27-29)17-6-8-19(9-7-17)34-20-10-12-21(13-11-20)35(2,32)33/h3,6-13,16,18H,1,4-5,14-15H2,2H3,(H2,26,31)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303563
PNG
(US10138229, Example 75)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccc(cc2)C#N)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23N5O3/c1-2-23(31)29-13-3-4-19(15-29)30-16-22(25(27)32)24(28-30)18-7-11-21(12-8-18)33-20-9-5-17(14-26)6-10-20/h2,5-12,16,19H,1,3-4,13,15H2,(H2,27,32)/t19-/m1/s1
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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 6.60E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303503
PNG
(US10138229, Example 14)
Show SMILES Cc1cc(C)n(n1)-c1ccc(cc1)-c1nn(cc1C(N)=O)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H26N6O2/c1-4-21(30)27-11-5-6-19(13-27)28-14-20(23(24)31)22(26-28)17-7-9-18(10-8-17)29-16(3)12-15(2)25-29/h4,7-10,12,14,19H,1,5-6,11,13H2,2-3H3,(H2,24,31)/t19-/m1/s1
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n/an/a 7.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM303582
PNG
(US10138229, Example 94)
Show SMILES NC(=O)c1cn(nc1-c1ccc(cc1)C(=O)N1CCCCC1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H29N5O3/c1-2-21(30)28-14-6-7-19(15-28)29-16-20(23(25)31)22(26-29)17-8-10-18(11-9-17)24(32)27-12-4-3-5-13-27/h2,8-11,16,19H,1,3-7,12-15H2,(H2,25,31)/t19-/m1/s1
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UniProtKB/SwissProt

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n/an/a 8.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...


US Patent US10138229 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%