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Patent code US10143695

Compile Data Set for Download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304254
PNG
(US10143695, Compound 78)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C46H43N11O7/c1-53-23-29(18-36(53)43(59)49-30-19-37(54(2)24-30)46(62)56-14-13-27-16-28(47)11-12-34(27)56)50-44(60)42-52-40(25-55(42)3)51-41(58)10-7-15-64-39-21-33-32(20-38(39)63-4)45(61)57-31(22-48-33)17-26-8-5-6-9-35(26)57/h5-6,8-9,11-14,16,18-25,31H,7,10,15,17,47H2,1-4H3,(H,49,59)(H,50,60)(H,51,58)/t31-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0600n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304255
PNG
(US10143695, Compound 79)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-9-8-25(43)12-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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PC sid
UniChem
US Patent
n/an/a 0.0900n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304241
PNG
(US10143695, Compound 8A)
Show SMILES COC(=O)c1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C45H44N10O9/c1-25-14-30-20-46-32-19-37(36(62-5)18-31(32)43(59)55(30)21-25)64-13-7-8-39(56)49-38-24-53(4)40(50-38)42(58)48-28-16-34(51(2)22-28)41(57)47-29-17-35(52(3)23-29)44(60)54-12-11-26-15-27(45(61)63-6)9-10-33(26)54/h9-12,15-20,22-24,30H,1,7-8,13-14,21H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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PC sid
UniChem
US Patent
n/an/a 0.140n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304234
PNG
(US10143695, Compound 8)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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PC sid
UniChem
US Patent
n/an/a 0.150n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304240
PNG
(US10143695, Compound 7A)
Show SMILES COc1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H44N10O8/c1-25-14-29-20-45-32-19-37(36(61-6)18-31(32)43(58)54(29)21-25)62-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(60-5)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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PC sid
UniChem
US Patent
n/an/a 0.150n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304245
PNG
(US10143695, Compound 28)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-12-25(43)9-8-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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PC sid
UniChem
US Patent
n/an/a 0.160n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304257
PNG
(US10143695, Compound 83)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(CN)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H45N11O7/c1-25-13-30-20-46-32-18-37(36(61-5)17-31(32)43(59)55(30)21-25)62-12-6-7-39(56)49-38-24-53(4)40(50-38)42(58)48-28-15-34(51(2)22-28)41(57)47-29-16-35(52(3)23-29)44(60)54-11-10-27-14-26(19-45)8-9-33(27)54/h8-11,14-18,20,22-24,30H,1,6-7,12-13,19,21,45H2,2-5H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.180n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304242
PNG
(US10143695, Compound 19)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(SC)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O7S/c1-25-14-29-20-45-32-19-37(36(60-5)18-31(32)43(58)54(29)21-25)61-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(62-6)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
PDB
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304246
PNG
(US10143695, Compound 13A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-8-9-26(44)14-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
PDB
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.280n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304254
PNG
(US10143695, Compound 78)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C46H43N11O7/c1-53-23-29(18-36(53)43(59)49-30-19-37(54(2)24-30)46(62)56-14-13-27-16-28(47)11-12-34(27)56)50-44(60)42-52-40(25-55(42)3)51-41(58)10-7-15-64-39-21-33-32(20-38(39)63-4)45(61)57-31(22-48-33)17-26-8-5-6-9-35(26)57/h5-6,8-9,11-14,16,18-25,31H,7,10,15,17,47H2,1-4H3,(H,49,59)(H,50,60)(H,51,58)/t31-/m0/s1
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UniChem
US Patent
n/an/a 0.290n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304247
PNG
(US10143695, Compound 48)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1nc(cs1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H40N10O7S/c1-23-12-28-18-44-30-17-36(35(58-4)16-29(30)40(56)52(28)19-23)59-11-5-6-37(53)48-42-47-31(22-60-42)38(54)45-26-14-33(49(2)20-26)39(55)46-27-15-34(50(3)21-27)41(57)51-10-9-24-13-25(43)7-8-32(24)51/h7-10,13-18,20-22,28H,1,5-6,11-12,19,43H2,2-4H3,(H,45,54)(H,46,55)(H,47,48,53)/t28-/m0/s1
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PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304240
PNG
(US10143695, Compound 7A)
Show SMILES COc1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H44N10O8/c1-25-14-29-20-45-32-19-37(36(61-6)18-31(32)43(58)54(29)21-25)62-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(60-5)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304255
PNG
(US10143695, Compound 79)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-9-8-25(43)12-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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UniChem
US Patent
n/an/a 0.310n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304242
PNG
(US10143695, Compound 19)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(SC)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O7S/c1-25-14-29-20-45-32-19-37(36(60-5)18-31(32)43(58)54(29)21-25)61-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(62-6)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.350n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304235
PNG
(US10143695, Compound 12)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)n3ccc4cc(N)ccc34)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-27-16-31(30(51-4)15-26(27)36(49)46(25)18-21)52-11-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-24-14-29(43(2)19-24)37(50)45-10-9-22-13-23(38)7-8-28(22)45/h7-10,13-17,19-20,25H,1,5-6,11-12,18,38H2,2-4H3,(H,40,48)(H,41,47)/t25-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304234
PNG
(US10143695, Compound 8)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 0.430n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304241
PNG
(US10143695, Compound 8A)
Show SMILES COC(=O)c1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C45H44N10O9/c1-25-14-30-20-46-32-19-37(36(62-5)18-31(32)43(59)55(30)21-25)64-13-7-8-39(56)49-38-24-53(4)40(50-38)42(58)48-28-16-34(51(2)22-28)41(57)47-29-17-35(52(3)23-29)44(60)54-12-11-26-15-27(45(61)63-6)9-10-33(26)54/h9-12,15-20,22-24,30H,1,7-8,13-14,21H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304259
PNG
(US10143695, Compound 85)
Show SMILES COC(=O)c1cnc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H43N11O9/c1-24-12-29-19-45-31-17-35(34(62-5)16-30(31)42(59)55(29)20-24)64-11-7-8-37(56)49-36-23-53(4)39(50-36)41(58)48-27-14-32(51(2)21-27)40(57)47-28-15-33(52(3)22-28)43(60)54-10-9-25-13-26(44(61)63-6)18-46-38(25)54/h9-10,13-19,21-23,29H,1,7-8,11-12,20H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t29-/m0/s1
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n/an/a 0.580n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304242
PNG
(US10143695, Compound 19)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(SC)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O7S/c1-25-14-29-20-45-32-19-37(36(60-5)18-31(32)43(58)54(29)21-25)61-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(62-6)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 0.590n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304240
PNG
(US10143695, Compound 7A)
Show SMILES COc1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H44N10O8/c1-25-14-29-20-45-32-19-37(36(61-6)18-31(32)43(58)54(29)21-25)62-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(60-5)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304245
PNG
(US10143695, Compound 28)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-12-25(43)9-8-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304254
PNG
(US10143695, Compound 78)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C46H43N11O7/c1-53-23-29(18-36(53)43(59)49-30-19-37(54(2)24-30)46(62)56-14-13-27-16-28(47)11-12-34(27)56)50-44(60)42-52-40(25-55(42)3)51-41(58)10-7-15-64-39-21-33-32(20-38(39)63-4)45(61)57-31(22-48-33)17-26-8-5-6-9-35(26)57/h5-6,8-9,11-14,16,18-25,31H,7,10,15,17,47H2,1-4H3,(H,49,59)(H,50,60)(H,51,58)/t31-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304258
PNG
(US10143695, Compound 84)
Show SMILES Cn1cc(NC(=O)c2nc(NC(=O)CCCOc3cc4N=C[C@@H]5CC(=C)CN5C(=O)c4cc3O)cn2C)cc1C(=O)Nc1cnc2[nH]ccc2c1
Show InChI InChI=1S/C35H34N10O6/c1-19-9-23-15-37-25-13-28(27(46)12-24(25)35(50)45(23)16-19)51-8-4-5-30(47)41-29-18-44(3)32(42-29)34(49)40-22-11-26(43(2)17-22)33(48)39-21-10-20-6-7-36-31(20)38-14-21/h6-7,10-15,17-18,23,46H,1,4-5,8-9,16H2,2-3H3,(H,36,38)(H,39,48)(H,40,49)(H,41,47)/t23-/m0/s1
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n/an/a 0.660n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304255
PNG
(US10143695, Compound 79)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-9-8-25(43)12-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304244
PNG
(US10143695, Compound 11A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5c(N)cccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-14-27-19-45-31-18-36(35(60-5)17-29(31)42(58)54(27)20-24)61-13-7-10-38(55)48-37-23-52(4)39(49-37)41(57)47-25-15-33(50(2)21-25)40(56)46-26-16-34(51(3)22-26)43(59)53-12-11-28-30(44)8-6-9-32(28)53/h6,8-9,11-12,15-19,21-23,27H,1,7,10,13-14,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t27-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304247
PNG
(US10143695, Compound 48)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1nc(cs1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H40N10O7S/c1-23-12-28-18-44-30-17-36(35(58-4)16-29(30)40(56)52(28)19-23)59-11-5-6-37(53)48-42-47-31(22-60-42)38(54)45-26-14-33(49(2)20-26)39(55)46-27-15-34(50(3)21-27)41(57)51-10-9-24-13-25(43)7-8-32(24)51/h7-10,13-18,20-22,28H,1,5-6,11-12,19,43H2,2-4H3,(H,45,54)(H,46,55)(H,47,48,53)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304246
PNG
(US10143695, Compound 13A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-8-9-26(44)14-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304257
PNG
(US10143695, Compound 83)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(CN)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H45N11O7/c1-25-13-30-20-46-32-18-37(36(61-5)17-31(32)43(59)55(30)21-25)62-12-6-7-39(56)49-38-24-53(4)40(50-38)42(58)48-28-15-34(51(2)22-28)41(57)47-29-16-35(52(3)23-29)44(60)54-11-10-27-14-26(19-45)8-9-33(27)54/h8-11,14-18,20,22-24,30H,1,6-7,12-13,19,21,45H2,2-5H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304241
PNG
(US10143695, Compound 8A)
Show SMILES COC(=O)c1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C45H44N10O9/c1-25-14-30-20-46-32-19-37(36(62-5)18-31(32)43(59)55(30)21-25)64-13-7-8-39(56)49-38-24-53(4)40(50-38)42(58)48-28-16-34(51(2)22-28)41(57)47-29-17-35(52(3)23-29)44(60)54-12-11-26-15-27(45(61)63-6)9-10-33(26)54/h9-12,15-20,22-24,30H,1,7-8,13-14,21H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304234
PNG
(US10143695, Compound 8)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304259
PNG
(US10143695, Compound 85)
Show SMILES COC(=O)c1cnc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H43N11O9/c1-24-12-29-19-45-31-17-35(34(62-5)16-30(31)42(59)55(29)20-24)64-11-7-8-37(56)49-36-23-53(4)39(50-36)41(58)48-27-14-32(51(2)21-27)40(57)47-28-15-33(52(3)22-28)43(60)54-10-9-25-13-26(44(61)63-6)18-46-38(25)54/h9-10,13-19,21-23,29H,1,7-8,11-12,20H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t29-/m0/s1
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n/an/a 0.970n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304238
PNG
(US10143695, Compound 5A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)N3Cc4ccc(N)cc4C3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H39N9O6/c1-21-10-26-15-39-28-14-31(30(51-4)13-27(28)36(49)46(26)16-21)52-9-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-25-12-29(43(2)19-25)37(50)45-17-22-7-8-24(38)11-23(22)18-45/h7-8,11-15,19-20,26H,1,5-6,9-10,16-18,38H2,2-4H3,(H,40,48)(H,41,47)/t26-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304245
PNG
(US10143695, Compound 28)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-12-25(43)9-8-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304240
PNG
(US10143695, Compound 7A)
Show SMILES COc1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H44N10O8/c1-25-14-29-20-45-32-19-37(36(61-6)18-31(32)43(58)54(29)21-25)62-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(60-5)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304254
PNG
(US10143695, Compound 78)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C46H43N11O7/c1-53-23-29(18-36(53)43(59)49-30-19-37(54(2)24-30)46(62)56-14-13-27-16-28(47)11-12-34(27)56)50-44(60)42-52-40(25-55(42)3)51-41(58)10-7-15-64-39-21-33-32(20-38(39)63-4)45(61)57-31(22-48-33)17-26-8-5-6-9-35(26)57/h5-6,8-9,11-14,16,18-25,31H,7,10,15,17,47H2,1-4H3,(H,49,59)(H,50,60)(H,51,58)/t31-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304257
PNG
(US10143695, Compound 83)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(CN)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H45N11O7/c1-25-13-30-20-46-32-18-37(36(61-5)17-31(32)43(59)55(30)21-25)62-12-6-7-39(56)49-38-24-53(4)40(50-38)42(58)48-28-15-34(51(2)22-28)41(57)47-29-16-35(52(3)23-29)44(60)54-11-10-27-14-26(19-45)8-9-33(27)54/h8-11,14-18,20,22-24,30H,1,6-7,12-13,19,21,45H2,2-5H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304242
PNG
(US10143695, Compound 19)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(SC)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O7S/c1-25-14-29-20-45-32-19-37(36(60-5)18-31(32)43(58)54(29)21-25)61-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(62-6)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304253
PNG
(US10143695, Compound 77)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4CCc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-9,14-19,21-23,29H,1,6-7,10-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304252
PNG
(US10143695, Compound 69)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C42H45N9O8/c1-48-23-27(17-33(48)39(54)43-12-8-13-52)46-41(56)35-18-28(24-50(35)3)47-40(55)34-16-26(22-49(34)2)45-38(53)11-7-14-59-37-20-31-30(19-36(37)58-4)42(57)51-29(21-44-31)15-25-9-5-6-10-32(25)51/h5-6,9-10,16-24,29,52H,7-8,11-15H2,1-4H3,(H,43,54)(H,45,53)(H,46,56)(H,47,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304239
PNG
(US10143695, Compound 6A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4Cc5ccc(N)cc5C4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-11-30-17-45-32-16-36(35(60-5)15-31(32)42(58)54(30)18-24)61-10-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-28-13-33(50(2)21-28)40(56)46-29-14-34(51(3)22-29)43(59)53-19-25-8-9-27(44)12-26(25)20-53/h8-9,12-17,21-23,30H,1,6-7,10-11,18-20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304244
PNG
(US10143695, Compound 11A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5c(N)cccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-14-27-19-45-31-18-36(35(60-5)17-29(31)42(58)54(27)20-24)61-13-7-10-38(55)48-37-23-52(4)39(49-37)41(57)47-25-15-33(50(2)21-25)40(56)46-26-16-34(51(3)22-26)43(59)53-12-11-28-30(44)8-6-9-32(28)53/h6,8-9,11-12,15-19,21-23,27H,1,7,10,13-14,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t27-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304252
PNG
(US10143695, Compound 69)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C42H45N9O8/c1-48-23-27(17-33(48)39(54)43-12-8-13-52)46-41(56)35-18-28(24-50(35)3)47-40(55)34-16-26(22-49(34)2)45-38(53)11-7-14-59-37-20-31-30(19-36(37)58-4)42(57)51-29(21-44-31)15-25-9-5-6-10-32(25)51/h5-6,9-10,16-24,29,52H,7-8,11-15H2,1-4H3,(H,43,54)(H,45,53)(H,46,56)(H,47,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304258
PNG
(US10143695, Compound 84)
Show SMILES Cn1cc(NC(=O)c2nc(NC(=O)CCCOc3cc4N=C[C@@H]5CC(=C)CN5C(=O)c4cc3O)cn2C)cc1C(=O)Nc1cnc2[nH]ccc2c1
Show InChI InChI=1S/C35H34N10O6/c1-19-9-23-15-37-25-13-28(27(46)12-24(25)35(50)45(23)16-19)51-8-4-5-30(47)41-29-18-44(3)32(42-29)34(49)40-22-11-26(43(2)17-22)33(48)39-21-10-20-6-7-36-31(20)38-14-21/h6-7,10-15,17-18,23,46H,1,4-5,8-9,16H2,2-3H3,(H,36,38)(H,39,48)(H,40,49)(H,41,47)/t23-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304254
PNG
(US10143695, Compound 78)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C46H43N11O7/c1-53-23-29(18-36(53)43(59)49-30-19-37(54(2)24-30)46(62)56-14-13-27-16-28(47)11-12-34(27)56)50-44(60)42-52-40(25-55(42)3)51-41(58)10-7-15-64-39-21-33-32(20-38(39)63-4)45(61)57-31(22-48-33)17-26-8-5-6-9-35(26)57/h5-6,8-9,11-14,16,18-25,31H,7,10,15,17,47H2,1-4H3,(H,49,59)(H,50,60)(H,51,58)/t31-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304235
PNG
(US10143695, Compound 12)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)n3ccc4cc(N)ccc34)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-27-16-31(30(51-4)15-26(27)36(49)46(25)18-21)52-11-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-24-14-29(43(2)19-24)37(50)45-10-9-22-13-23(38)7-8-28(22)45/h7-10,13-17,19-20,25H,1,5-6,11-12,18,38H2,2-4H3,(H,40,48)(H,41,47)/t25-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304249
PNG
(US10143695, Compound 55)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C39H45N9O8/c1-23-12-27-18-41-29-17-34(33(55-5)16-28(29)39(54)48(27)19-23)56-11-6-8-35(50)42-24-13-31(46(3)20-24)37(52)44-26-15-32(47(4)22-26)38(53)43-25-14-30(45(2)21-25)36(51)40-9-7-10-49/h13-18,20-22,27,49H,1,6-12,19H2,2-5H3,(H,40,51)(H,42,50)(H,43,53)(H,44,52)/t27-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304255
PNG
(US10143695, Compound 79)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-9-8-25(43)12-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304242
PNG
(US10143695, Compound 19)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(SC)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O7S/c1-25-14-29-20-45-32-19-37(36(60-5)18-31(32)43(58)54(29)21-25)61-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(62-6)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304234
PNG
(US10143695, Compound 8)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304257
PNG
(US10143695, Compound 83)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(CN)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H45N11O7/c1-25-13-30-20-46-32-18-37(36(61-5)17-31(32)43(59)55(30)21-25)62-12-6-7-39(56)49-38-24-53(4)40(50-38)42(58)48-28-15-34(51(2)22-28)41(57)47-29-16-35(52(3)23-29)44(60)54-11-10-27-14-26(19-45)8-9-33(27)54/h8-11,14-18,20,22-24,30H,1,6-7,12-13,19,21,45H2,2-5H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304257
PNG
(US10143695, Compound 83)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(CN)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H45N11O7/c1-25-13-30-20-46-32-18-37(36(61-5)17-31(32)43(59)55(30)21-25)62-12-6-7-39(56)49-38-24-53(4)40(50-38)42(58)48-28-15-34(51(2)22-28)41(57)47-29-16-35(52(3)23-29)44(60)54-11-10-27-14-26(19-45)8-9-33(27)54/h8-11,14-18,20,22-24,30H,1,6-7,12-13,19,21,45H2,2-5H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304246
PNG
(US10143695, Compound 13A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-8-9-26(44)14-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304249
PNG
(US10143695, Compound 55)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C39H45N9O8/c1-23-12-27-18-41-29-17-34(33(55-5)16-28(29)39(54)48(27)19-23)56-11-6-8-35(50)42-24-13-31(46(3)20-24)37(52)44-26-15-32(47(4)22-26)38(53)43-25-14-30(45(2)21-25)36(51)40-9-7-10-49/h13-18,20-22,27,49H,1,6-12,19H2,2-5H3,(H,40,51)(H,42,50)(H,43,53)(H,44,52)/t27-/m1/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304245
PNG
(US10143695, Compound 28)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-12-25(43)9-8-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304255
PNG
(US10143695, Compound 79)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-9-8-25(43)12-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304240
PNG
(US10143695, Compound 7A)
Show SMILES COc1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H44N10O8/c1-25-14-29-20-45-32-19-37(36(61-6)18-31(32)43(58)54(29)21-25)62-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(60-5)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304245
PNG
(US10143695, Compound 28)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-12-25(43)9-8-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304241
PNG
(US10143695, Compound 8A)
Show SMILES COC(=O)c1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C45H44N10O9/c1-25-14-30-20-46-32-19-37(36(62-5)18-31(32)43(59)55(30)21-25)64-13-7-8-39(56)49-38-24-53(4)40(50-38)42(58)48-28-16-34(51(2)22-28)41(57)47-29-17-35(52(3)23-29)44(60)54-12-11-26-15-27(45(61)63-6)9-10-33(26)54/h9-12,15-20,22-24,30H,1,7-8,13-14,21H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304238
PNG
(US10143695, Compound 5A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)N3Cc4ccc(N)cc4C3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H39N9O6/c1-21-10-26-15-39-28-14-31(30(51-4)13-27(28)36(49)46(26)16-21)52-9-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-25-12-29(43(2)19-25)37(50)45-17-22-7-8-24(38)11-23(22)18-45/h7-8,11-15,19-20,26H,1,5-6,9-10,16-18,38H2,2-4H3,(H,40,48)(H,41,47)/t26-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304252
PNG
(US10143695, Compound 69)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C42H45N9O8/c1-48-23-27(17-33(48)39(54)43-12-8-13-52)46-41(56)35-18-28(24-50(35)3)47-40(55)34-16-26(22-49(34)2)45-38(53)11-7-14-59-37-20-31-30(19-36(37)58-4)42(57)51-29(21-44-31)15-25-9-5-6-10-32(25)51/h5-6,9-10,16-24,29,52H,7-8,11-15H2,1-4H3,(H,43,54)(H,45,53)(H,46,56)(H,47,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304258
PNG
(US10143695, Compound 84)
Show SMILES Cn1cc(NC(=O)c2nc(NC(=O)CCCOc3cc4N=C[C@@H]5CC(=C)CN5C(=O)c4cc3O)cn2C)cc1C(=O)Nc1cnc2[nH]ccc2c1
Show InChI InChI=1S/C35H34N10O6/c1-19-9-23-15-37-25-13-28(27(46)12-24(25)35(50)45(23)16-19)51-8-4-5-30(47)41-29-18-44(3)32(42-29)34(49)40-22-11-26(43(2)17-22)33(48)39-21-10-20-6-7-36-31(20)38-14-21/h6-7,10-15,17-18,23,46H,1,4-5,8-9,16H2,2-3H3,(H,36,38)(H,39,48)(H,40,49)(H,41,47)/t23-/m0/s1
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n/an/a 3.60n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304246
PNG
(US10143695, Compound 13A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-8-9-26(44)14-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304256
PNG
(US10143695, Compound 82)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3ccc4[nH]ccc4c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-28-16-31(30(51-4)15-26(28)37(50)46(25)18-21)52-11-5-6-33(47)42-32-20-45(3)34(43-32)36(49)41-24-14-29(44(2)19-24)35(48)40-23-7-8-27-22(13-23)9-10-38-27/h7-10,13-17,19-20,25,38H,1,5-6,11-12,18H2,2-4H3,(H,40,48)(H,41,49)(H,42,47)/t25-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304241
PNG
(US10143695, Compound 8A)
Show SMILES COC(=O)c1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C45H44N10O9/c1-25-14-30-20-46-32-19-37(36(62-5)18-31(32)43(59)55(30)21-25)64-13-7-8-39(56)49-38-24-53(4)40(50-38)42(58)48-28-16-34(51(2)22-28)41(57)47-29-17-35(52(3)23-29)44(60)54-12-11-26-15-27(45(61)63-6)9-10-33(26)54/h9-12,15-20,22-24,30H,1,7-8,13-14,21H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304258
PNG
(US10143695, Compound 84)
Show SMILES Cn1cc(NC(=O)c2nc(NC(=O)CCCOc3cc4N=C[C@@H]5CC(=C)CN5C(=O)c4cc3O)cn2C)cc1C(=O)Nc1cnc2[nH]ccc2c1
Show InChI InChI=1S/C35H34N10O6/c1-19-9-23-15-37-25-13-28(27(46)12-24(25)35(50)45(23)16-19)51-8-4-5-30(47)41-29-18-44(3)32(42-29)34(49)40-22-11-26(43(2)17-22)33(48)39-21-10-20-6-7-36-31(20)38-14-21/h6-7,10-15,17-18,23,46H,1,4-5,8-9,16H2,2-3H3,(H,36,38)(H,39,48)(H,40,49)(H,41,47)/t23-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304244
PNG
(US10143695, Compound 11A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5c(N)cccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-14-27-19-45-31-18-36(35(60-5)17-29(31)42(58)54(27)20-24)61-13-7-10-38(55)48-37-23-52(4)39(49-37)41(57)47-25-15-33(50(2)21-25)40(56)46-26-16-34(51(3)22-26)43(59)53-12-11-28-30(44)8-6-9-32(28)53/h6,8-9,11-12,15-19,21-23,27H,1,7,10,13-14,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t27-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304234
PNG
(US10143695, Compound 8)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304247
PNG
(US10143695, Compound 48)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1nc(cs1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H40N10O7S/c1-23-12-28-18-44-30-17-36(35(58-4)16-29(30)40(56)52(28)19-23)59-11-5-6-37(53)48-42-47-31(22-60-42)38(54)45-26-14-33(49(2)20-26)39(55)46-27-15-34(50(3)21-27)41(57)51-10-9-24-13-25(43)7-8-32(24)51/h7-10,13-18,20-22,28H,1,5-6,11-12,19,43H2,2-4H3,(H,45,54)(H,46,55)(H,47,48,53)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304239
PNG
(US10143695, Compound 6A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4Cc5ccc(N)cc5C4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-11-30-17-45-32-16-36(35(60-5)15-31(32)42(58)54(30)18-24)61-10-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-28-13-33(50(2)21-28)40(56)46-29-14-34(51(3)22-29)43(59)53-19-25-8-9-27(44)12-26(25)20-53/h8-9,12-17,21-23,30H,1,6-7,10-11,18-20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304246
PNG
(US10143695, Compound 13A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5ccc(N)cc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-8-9-26(44)14-32(25)53/h8-11,14-19,21-23,29H,1,6-7,12-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304235
PNG
(US10143695, Compound 12)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)n3ccc4cc(N)ccc34)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-27-16-31(30(51-4)15-26(27)36(49)46(25)18-21)52-11-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-24-14-29(43(2)19-24)37(50)45-10-9-22-13-23(38)7-8-28(22)45/h7-10,13-17,19-20,25H,1,5-6,11-12,18,38H2,2-4H3,(H,40,48)(H,41,47)/t25-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304247
PNG
(US10143695, Compound 48)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1nc(cs1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H40N10O7S/c1-23-12-28-18-44-30-17-36(35(58-4)16-29(30)40(56)52(28)19-23)59-11-5-6-37(53)48-42-47-31(22-60-42)38(54)45-26-14-33(49(2)20-26)39(55)46-27-15-34(50(3)21-27)41(57)51-10-9-24-13-25(43)7-8-32(24)51/h7-10,13-18,20-22,28H,1,5-6,11-12,19,43H2,2-4H3,(H,45,54)(H,46,55)(H,47,48,53)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304252
PNG
(US10143695, Compound 69)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C42H45N9O8/c1-48-23-27(17-33(48)39(54)43-12-8-13-52)46-41(56)35-18-28(24-50(35)3)47-40(55)34-16-26(22-49(34)2)45-38(53)11-7-14-59-37-20-31-30(19-36(37)58-4)42(57)51-29(21-44-31)15-25-9-5-6-10-32(25)51/h5-6,9-10,16-24,29,52H,7-8,11-15H2,1-4H3,(H,43,54)(H,45,53)(H,46,56)(H,47,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304249
PNG
(US10143695, Compound 55)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C39H45N9O8/c1-23-12-27-18-41-29-17-34(33(55-5)16-28(29)39(54)48(27)19-23)56-11-6-8-35(50)42-24-13-31(46(3)20-24)37(52)44-26-15-32(47(4)22-26)38(53)43-25-14-30(45(2)21-25)36(51)40-9-7-10-49/h13-18,20-22,27,49H,1,6-12,19H2,2-5H3,(H,40,51)(H,42,50)(H,43,53)(H,44,52)/t27-/m1/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304238
PNG
(US10143695, Compound 5A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)N3Cc4ccc(N)cc4C3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H39N9O6/c1-21-10-26-15-39-28-14-31(30(51-4)13-27(28)36(49)46(26)16-21)52-9-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-25-12-29(43(2)19-25)37(50)45-17-22-7-8-24(38)11-23(22)18-45/h7-8,11-15,19-20,26H,1,5-6,9-10,16-18,38H2,2-4H3,(H,40,48)(H,41,47)/t26-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304239
PNG
(US10143695, Compound 6A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4Cc5ccc(N)cc5C4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-11-30-17-45-32-16-36(35(60-5)15-31(32)42(58)54(30)18-24)61-10-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-28-13-33(50(2)21-28)40(56)46-29-14-34(51(3)22-29)43(59)53-19-25-8-9-27(44)12-26(25)20-53/h8-9,12-17,21-23,30H,1,6-7,10-11,18-20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t30-/m0/s1
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n/an/a 5.30n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304258
PNG
(US10143695, Compound 84)
Show SMILES Cn1cc(NC(=O)c2nc(NC(=O)CCCOc3cc4N=C[C@@H]5CC(=C)CN5C(=O)c4cc3O)cn2C)cc1C(=O)Nc1cnc2[nH]ccc2c1
Show InChI InChI=1S/C35H34N10O6/c1-19-9-23-15-37-25-13-28(27(46)12-24(25)35(50)45(23)16-19)51-8-4-5-30(47)41-29-18-44(3)32(42-29)34(49)40-22-11-26(43(2)17-22)33(48)39-21-10-20-6-7-36-31(20)38-14-21/h6-7,10-15,17-18,23,46H,1,4-5,8-9,16H2,2-3H3,(H,36,38)(H,39,48)(H,40,49)(H,41,47)/t23-/m0/s1
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n/an/a 5.40n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304243
PNG
(US10143695, Compound 20)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(ccc45)S(C)(=O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O9S/c1-25-14-29-20-45-32-19-37(36(62-5)18-31(32)43(58)54(29)21-25)63-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(64(6,60)61)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304259
PNG
(US10143695, Compound 85)
Show SMILES COC(=O)c1cnc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H43N11O9/c1-24-12-29-19-45-31-17-35(34(62-5)16-30(31)42(59)55(29)20-24)64-11-7-8-37(56)49-36-23-53(4)39(50-36)41(58)48-27-14-32(51(2)21-27)40(57)47-28-15-33(52(3)22-28)43(60)54-10-9-25-13-26(44(61)63-6)18-46-38(25)54/h9-10,13-19,21-23,29H,1,7-8,11-12,20H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304253
PNG
(US10143695, Compound 77)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4CCc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-9,14-19,21-23,29H,1,6-7,10-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304235
PNG
(US10143695, Compound 12)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)n3ccc4cc(N)ccc34)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-27-16-31(30(51-4)15-26(27)36(49)46(25)18-21)52-11-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-24-14-29(43(2)19-24)37(50)45-10-9-22-13-23(38)7-8-28(22)45/h7-10,13-17,19-20,25H,1,5-6,11-12,18,38H2,2-4H3,(H,40,48)(H,41,47)/t25-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304249
PNG
(US10143695, Compound 55)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C39H45N9O8/c1-23-12-27-18-41-29-17-34(33(55-5)16-28(29)39(54)48(27)19-23)56-11-6-8-35(50)42-24-13-31(46(3)20-24)37(52)44-26-15-32(47(4)22-26)38(53)43-25-14-30(45(2)21-25)36(51)40-9-7-10-49/h13-18,20-22,27,49H,1,6-12,19H2,2-5H3,(H,40,51)(H,42,50)(H,43,53)(H,44,52)/t27-/m1/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304247
PNG
(US10143695, Compound 48)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1nc(cs1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H40N10O7S/c1-23-12-28-18-44-30-17-36(35(58-4)16-29(30)40(56)52(28)19-23)59-11-5-6-37(53)48-42-47-31(22-60-42)38(54)45-26-14-33(49(2)20-26)39(55)46-27-15-34(50(3)21-27)41(57)51-10-9-24-13-25(43)7-8-32(24)51/h7-10,13-18,20-22,28H,1,5-6,11-12,19,43H2,2-4H3,(H,45,54)(H,46,55)(H,47,48,53)/t28-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304256
PNG
(US10143695, Compound 82)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3ccc4[nH]ccc4c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-28-16-31(30(51-4)15-26(28)37(50)46(25)18-21)52-11-5-6-33(47)42-32-20-45(3)34(43-32)36(49)41-24-14-29(44(2)19-24)35(48)40-23-7-8-27-22(13-23)9-10-38-27/h7-10,13-17,19-20,25,38H,1,5-6,11-12,18H2,2-4H3,(H,40,48)(H,41,49)(H,42,47)/t25-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304250
PNG
(US10143695, Compound 56)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCCCO)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C38H44N10O8/c1-22-12-25-17-40-27-16-31(30(55-5)15-26(27)38(54)48(25)18-22)56-11-6-8-33(50)43-32-21-47(4)34(44-32)37(53)42-24-14-29(46(3)20-24)36(52)41-23-13-28(45(2)19-23)35(51)39-9-7-10-49/h13-17,19-21,25,49H,1,6-12,18H2,2-5H3,(H,39,51)(H,41,52)(H,42,53)(H,43,50)/t25-/m1/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304259
PNG
(US10143695, Compound 85)
Show SMILES COC(=O)c1cnc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H43N11O9/c1-24-12-29-19-45-31-17-35(34(62-5)16-30(31)42(59)55(29)20-24)64-11-7-8-37(56)49-36-23-53(4)39(50-36)41(58)48-27-14-32(51(2)21-27)40(57)47-28-15-33(52(3)22-28)43(60)54-10-9-25-13-26(44(61)63-6)18-46-38(25)54/h9-10,13-19,21-23,29H,1,7-8,11-12,20H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304253
PNG
(US10143695, Compound 77)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4CCc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-9,14-19,21-23,29H,1,6-7,10-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304239
PNG
(US10143695, Compound 6A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4Cc5ccc(N)cc5C4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-11-30-17-45-32-16-36(35(60-5)15-31(32)42(58)54(30)18-24)61-10-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-28-13-33(50(2)21-28)40(56)46-29-14-34(51(3)22-29)43(59)53-19-25-8-9-27(44)12-26(25)20-53/h8-9,12-17,21-23,30H,1,6-7,10-11,18-20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t30-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304250
PNG
(US10143695, Compound 56)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCCCO)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C38H44N10O8/c1-22-12-25-17-40-27-16-31(30(55-5)15-26(27)38(54)48(25)18-22)56-11-6-8-33(50)43-32-21-47(4)34(44-32)37(53)42-24-14-29(46(3)20-24)36(52)41-23-13-28(45(2)19-23)35(51)39-9-7-10-49/h13-17,19-21,25,49H,1,6-12,18H2,2-5H3,(H,39,51)(H,41,52)(H,42,53)(H,43,50)/t25-/m1/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304236
PNG
(US10143695, Compound 3A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)NCc3ccc(N)cc3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C36H39N9O6/c1-21-12-25-17-38-27-15-30(29(50-4)14-26(27)36(49)45(25)18-21)51-11-5-6-32(46)41-31-20-44(3)33(42-31)35(48)40-24-13-28(43(2)19-24)34(47)39-16-22-7-9-23(37)10-8-22/h7-10,13-15,17,19-20,25H,1,5-6,11-12,16,18,37H2,2-4H3,(H,39,47)(H,40,48)(H,41,46)/t25-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304237
PNG
(US10143695, Compound 4A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCc4ccc(N)cc4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H45N11O7/c1-24-13-29-19-44-31-17-35(34(59-5)16-30(31)42(58)53(29)20-24)60-12-6-7-37(54)48-36-23-52(4)38(49-36)41(57)47-28-15-33(51(3)22-28)40(56)46-27-14-32(50(2)21-27)39(55)45-18-25-8-10-26(43)11-9-25/h8-11,14-17,19,21-23,29H,1,6-7,12-13,18,20,43H2,2-5H3,(H,45,55)(H,46,56)(H,47,57)(H,48,54)/t29-/m0/s1
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Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304256
PNG
(US10143695, Compound 82)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3ccc4[nH]ccc4c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-28-16-31(30(51-4)15-26(28)37(50)46(25)18-21)52-11-5-6-33(47)42-32-20-45(3)34(43-32)36(49)41-24-14-29(44(2)19-24)35(48)40-23-7-8-27-22(13-23)9-10-38-27/h7-10,13-17,19-20,25,38H,1,5-6,11-12,18H2,2-4H3,(H,40,48)(H,41,49)(H,42,47)/t25-/m0/s1
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n/an/a 10.8n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304244
PNG
(US10143695, Compound 11A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5c(N)cccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-14-27-19-45-31-18-36(35(60-5)17-29(31)42(58)54(27)20-24)61-13-7-10-38(55)48-37-23-52(4)39(49-37)41(57)47-25-15-33(50(2)21-25)40(56)46-26-16-34(51(3)22-26)43(59)53-12-11-28-30(44)8-6-9-32(28)53/h6,8-9,11-12,15-19,21-23,27H,1,7,10,13-14,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t27-/m0/s1
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n/an/a 11.3n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304237
PNG
(US10143695, Compound 4A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCc4ccc(N)cc4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H45N11O7/c1-24-13-29-19-44-31-17-35(34(59-5)16-30(31)42(58)53(29)20-24)60-12-6-7-37(54)48-36-23-52(4)38(49-36)41(57)47-28-15-33(51(3)22-28)40(56)46-27-14-32(50(2)21-27)39(55)45-18-25-8-10-26(43)11-9-25/h8-11,14-17,19,21-23,29H,1,6-7,12-13,18,20,43H2,2-5H3,(H,45,55)(H,46,56)(H,47,57)(H,48,54)/t29-/m0/s1
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n/an/a 11.4n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304250
PNG
(US10143695, Compound 56)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCCCO)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C38H44N10O8/c1-22-12-25-17-40-27-16-31(30(55-5)15-26(27)38(54)48(25)18-22)56-11-6-8-33(50)43-32-21-47(4)34(44-32)37(53)42-24-14-29(46(3)20-24)36(52)41-23-13-28(45(2)19-23)35(51)39-9-7-10-49/h13-17,19-21,25,49H,1,6-12,18H2,2-5H3,(H,39,51)(H,41,52)(H,42,53)(H,43,50)/t25-/m1/s1
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n/an/a 13.6n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304235
PNG
(US10143695, Compound 12)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)n3ccc4cc(N)ccc34)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-27-16-31(30(51-4)15-26(27)36(49)46(25)18-21)52-11-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-24-14-29(43(2)19-24)37(50)45-10-9-22-13-23(38)7-8-28(22)45/h7-10,13-17,19-20,25H,1,5-6,11-12,18,38H2,2-4H3,(H,40,48)(H,41,47)/t25-/m0/s1
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n/an/a 13.9n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304236
PNG
(US10143695, Compound 3A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)NCc3ccc(N)cc3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C36H39N9O6/c1-21-12-25-17-38-27-15-30(29(50-4)14-26(27)36(49)45(25)18-21)51-11-5-6-32(46)41-31-20-44(3)33(42-31)35(48)40-24-13-28(43(2)19-24)34(47)39-16-22-7-9-23(37)10-8-22/h7-10,13-15,17,19-20,25H,1,5-6,11-12,16,18,37H2,2-4H3,(H,39,47)(H,40,48)(H,41,46)/t25-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304259
PNG
(US10143695, Compound 85)
Show SMILES COC(=O)c1cnc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C
Show InChI InChI=1S/C44H43N11O9/c1-24-12-29-19-45-31-17-35(34(62-5)16-30(31)42(59)55(29)20-24)64-11-7-8-37(56)49-36-23-53(4)39(50-36)41(58)48-27-14-32(51(2)21-27)40(57)47-28-15-33(52(3)22-28)43(60)54-10-9-25-13-26(44(61)63-6)18-46-38(25)54/h9-10,13-19,21-23,29H,1,7-8,11-12,20H2,2-6H3,(H,47,57)(H,48,58)(H,49,56)/t29-/m0/s1
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n/an/a 14.2n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304244
PNG
(US10143695, Compound 11A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5c(N)cccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H43N11O7/c1-24-14-27-19-45-31-18-36(35(60-5)17-29(31)42(58)54(27)20-24)61-13-7-10-38(55)48-37-23-52(4)39(49-37)41(57)47-25-15-33(50(2)21-25)40(56)46-26-16-34(51(3)22-26)43(59)53-12-11-28-30(44)8-6-9-32(28)53/h6,8-9,11-12,15-19,21-23,27H,1,7,10,13-14,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t27-/m0/s1
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n/an/a 14.8n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304253
PNG
(US10143695, Compound 77)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4CCc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-9,14-19,21-23,29H,1,6-7,10-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 14.9n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304251
PNG
(US10143695, Compound 66)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1CCCN1C2=O
Show InChI InChI=1S/C38H45N9O8/c1-44-21-24(15-29(44)35(50)39-10-7-12-48)42-37(52)31-16-25(22-46(31)3)43-36(51)30-14-23(20-45(30)2)41-34(49)9-6-13-55-33-18-28-27(17-32(33)54-4)38(53)47-11-5-8-26(47)19-40-28/h14-22,26,48H,5-13H2,1-4H3,(H,39,50)(H,41,49)(H,42,52)(H,43,51)/t26-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304251
PNG
(US10143695, Compound 66)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1CCCN1C2=O
Show InChI InChI=1S/C38H45N9O8/c1-44-21-24(15-29(44)35(50)39-10-7-12-48)42-37(52)31-16-25(22-46(31)3)43-36(51)30-14-23(20-45(30)2)41-34(49)9-6-13-55-33-18-28-27(17-32(33)54-4)38(53)47-11-5-8-26(47)19-40-28/h14-22,26,48H,5-13H2,1-4H3,(H,39,50)(H,41,49)(H,42,52)(H,43,51)/t26-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304238
PNG
(US10143695, Compound 5A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)N3Cc4ccc(N)cc4C3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H39N9O6/c1-21-10-26-15-39-28-14-31(30(51-4)13-27(28)36(49)46(26)16-21)52-9-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-25-12-29(43(2)19-25)37(50)45-17-22-7-8-24(38)11-23(22)18-45/h7-8,11-15,19-20,26H,1,5-6,9-10,16-18,38H2,2-4H3,(H,40,48)(H,41,47)/t26-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304239
PNG
(US10143695, Compound 6A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4Cc5ccc(N)cc5C4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-11-30-17-45-32-16-36(35(60-5)15-31(32)42(58)54(30)18-24)61-10-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-28-13-33(50(2)21-28)40(56)46-29-14-34(51(3)22-29)43(59)53-19-25-8-9-27(44)12-26(25)20-53/h8-9,12-17,21-23,30H,1,6-7,10-11,18-20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t30-/m0/s1
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n/an/a 17.1n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304243
PNG
(US10143695, Compound 20)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(ccc45)S(C)(=O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O9S/c1-25-14-29-20-45-32-19-37(36(62-5)18-31(32)43(58)54(29)21-25)63-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(64(6,60)61)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 19.9n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304250
PNG
(US10143695, Compound 56)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCCCO)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C38H44N10O8/c1-22-12-25-17-40-27-16-31(30(55-5)15-26(27)38(54)48(25)18-22)56-11-6-8-33(50)43-32-21-47(4)34(44-32)37(53)42-24-14-29(46(3)20-24)36(52)41-23-13-28(45(2)19-23)35(51)39-9-7-10-49/h13-17,19-21,25,49H,1,6-12,18H2,2-5H3,(H,39,51)(H,41,52)(H,42,53)(H,43,50)/t25-/m1/s1
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n/an/a 23.3n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304237
PNG
(US10143695, Compound 4A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCc4ccc(N)cc4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H45N11O7/c1-24-13-29-19-44-31-17-35(34(59-5)16-30(31)42(58)53(29)20-24)60-12-6-7-37(54)48-36-23-52(4)38(49-36)41(57)47-28-15-33(51(3)22-28)40(56)46-27-14-32(50(2)21-27)39(55)45-18-25-8-10-26(43)11-9-25/h8-11,14-17,19,21-23,29H,1,6-7,12-13,18,20,43H2,2-5H3,(H,45,55)(H,46,56)(H,47,57)(H,48,54)/t29-/m0/s1
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n/an/a 24.1n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304238
PNG
(US10143695, Compound 5A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)N3Cc4ccc(N)cc4C3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H39N9O6/c1-21-10-26-15-39-28-14-31(30(51-4)13-27(28)36(49)46(26)16-21)52-9-5-6-33(47)41-32-20-44(3)34(42-32)35(48)40-25-12-29(43(2)19-25)37(50)45-17-22-7-8-24(38)11-23(22)18-45/h7-8,11-15,19-20,26H,1,5-6,9-10,16-18,38H2,2-4H3,(H,40,48)(H,41,47)/t26-/m0/s1
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n/an/a 24.2n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304243
PNG
(US10143695, Compound 20)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(ccc45)S(C)(=O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O9S/c1-25-14-29-20-45-32-19-37(36(62-5)18-31(32)43(58)54(29)21-25)63-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(64(6,60)61)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304237
PNG
(US10143695, Compound 4A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCc4ccc(N)cc4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H45N11O7/c1-24-13-29-19-44-31-17-35(34(59-5)16-30(31)42(58)53(29)20-24)60-12-6-7-37(54)48-36-23-52(4)38(49-36)41(57)47-28-15-33(51(3)22-28)40(56)46-27-14-32(50(2)21-27)39(55)45-18-25-8-10-26(43)11-9-25/h8-11,14-17,19,21-23,29H,1,6-7,12-13,18,20,43H2,2-5H3,(H,45,55)(H,46,56)(H,47,57)(H,48,54)/t29-/m0/s1
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n/an/a 26.8n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304251
PNG
(US10143695, Compound 66)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1CCCN1C2=O
Show InChI InChI=1S/C38H45N9O8/c1-44-21-24(15-29(44)35(50)39-10-7-12-48)42-37(52)31-16-25(22-46(31)3)43-36(51)30-14-23(20-45(30)2)41-34(49)9-6-13-55-33-18-28-27(17-32(33)54-4)38(53)47-11-5-8-26(47)19-40-28/h14-22,26,48H,5-13H2,1-4H3,(H,39,50)(H,41,49)(H,42,52)(H,43,51)/t26-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304256
PNG
(US10143695, Compound 82)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3ccc4[nH]ccc4c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-28-16-31(30(51-4)15-26(28)37(50)46(25)18-21)52-11-5-6-33(47)42-32-20-45(3)34(43-32)36(49)41-24-14-29(44(2)19-24)35(48)40-23-7-8-27-22(13-23)9-10-38-27/h7-10,13-17,19-20,25,38H,1,5-6,11-12,18H2,2-4H3,(H,40,48)(H,41,49)(H,42,47)/t25-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304256
PNG
(US10143695, Compound 82)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3ccc4[nH]ccc4c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C37H37N9O6/c1-21-12-25-17-39-28-16-31(30(51-4)15-26(28)37(50)46(25)18-21)52-11-5-6-33(47)42-32-20-45(3)34(43-32)36(49)41-24-14-29(44(2)19-24)35(48)40-23-7-8-27-22(13-23)9-10-38-27/h7-10,13-17,19-20,25,38H,1,5-6,11-12,18H2,2-4H3,(H,40,48)(H,41,49)(H,42,47)/t25-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304253
PNG
(US10143695, Compound 77)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)N4CCc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C43H45N11O7/c1-24-13-29-19-45-31-18-36(35(60-5)17-30(31)42(58)54(29)20-24)61-12-6-7-38(55)48-37-23-52(4)39(49-37)41(57)47-27-15-33(50(2)21-27)40(56)46-28-16-34(51(3)22-28)43(59)53-11-10-25-14-26(44)8-9-32(25)53/h8-9,14-19,21-23,29H,1,6-7,10-13,20,44H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 37.1n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304249
PNG
(US10143695, Compound 55)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C39H45N9O8/c1-23-12-27-18-41-29-17-34(33(55-5)16-28(29)39(54)48(27)19-23)56-11-6-8-35(50)42-24-13-31(46(3)20-24)37(52)44-26-15-32(47(4)22-26)38(53)43-25-14-30(45(2)21-25)36(51)40-9-7-10-49/h13-18,20-22,27,49H,1,6-12,19H2,2-5H3,(H,40,51)(H,42,50)(H,43,53)(H,44,52)/t27-/m1/s1
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n/an/a 47n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304250
PNG
(US10143695, Compound 56)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCCCO)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C38H44N10O8/c1-22-12-25-17-40-27-16-31(30(55-5)15-26(27)38(54)48(25)18-22)56-11-6-8-33(50)43-32-21-47(4)34(44-32)37(53)42-24-14-29(46(3)20-24)36(52)41-23-13-28(45(2)19-23)35(51)39-9-7-10-49/h13-17,19-21,25,49H,1,6-12,18H2,2-5H3,(H,39,51)(H,41,52)(H,42,53)(H,43,50)/t25-/m1/s1
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n/an/a 54.5n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304236
PNG
(US10143695, Compound 3A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)NCc3ccc(N)cc3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C36H39N9O6/c1-21-12-25-17-38-27-15-30(29(50-4)14-26(27)36(49)45(25)18-21)51-11-5-6-32(46)41-31-20-44(3)33(42-31)35(48)40-24-13-28(43(2)19-24)34(47)39-16-22-7-9-23(37)10-8-22/h7-10,13-15,17,19-20,25H,1,5-6,11-12,16,18,37H2,2-4H3,(H,39,47)(H,40,48)(H,41,46)/t25-/m0/s1
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n/an/a 69n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304252
PNG
(US10143695, Compound 69)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O
Show InChI InChI=1S/C42H45N9O8/c1-48-23-27(17-33(48)39(54)43-12-8-13-52)46-41(56)35-18-28(24-50(35)3)47-40(55)34-16-26(22-49(34)2)45-38(53)11-7-14-59-37-20-31-30(19-36(37)58-4)42(57)51-29(21-44-31)15-25-9-5-6-10-32(25)51/h5-6,9-10,16-24,29,52H,7-8,11-15H2,1-4H3,(H,43,54)(H,45,53)(H,46,56)(H,47,55)/t29-/m0/s1
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n/an/a 69n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304251
PNG
(US10143695, Compound 66)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1CCCN1C2=O
Show InChI InChI=1S/C38H45N9O8/c1-44-21-24(15-29(44)35(50)39-10-7-12-48)42-37(52)31-16-25(22-46(31)3)43-36(51)30-14-23(20-45(30)2)41-34(49)9-6-13-55-33-18-28-27(17-32(33)54-4)38(53)47-11-5-8-26(47)19-40-28/h14-22,26,48H,5-13H2,1-4H3,(H,39,50)(H,41,49)(H,42,52)(H,43,51)/t26-/m0/s1
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n/an/a 86n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304236
PNG
(US10143695, Compound 3A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)NCc3ccc(N)cc3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C36H39N9O6/c1-21-12-25-17-38-27-15-30(29(50-4)14-26(27)36(49)45(25)18-21)51-11-5-6-32(46)41-31-20-44(3)33(42-31)35(48)40-24-13-28(43(2)19-24)34(47)39-16-22-7-9-23(37)10-8-22/h7-10,13-15,17,19-20,25H,1,5-6,11-12,16,18,37H2,2-4H3,(H,39,47)(H,40,48)(H,41,46)/t25-/m0/s1
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n/an/a 91n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304251
PNG
(US10143695, Compound 66)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1CCCN1C2=O
Show InChI InChI=1S/C38H45N9O8/c1-44-21-24(15-29(44)35(50)39-10-7-12-48)42-37(52)31-16-25(22-46(31)3)43-36(51)30-14-23(20-45(30)2)41-34(49)9-6-13-55-33-18-28-27(17-32(33)54-4)38(53)47-11-5-8-26(47)19-40-28/h14-22,26,48H,5-13H2,1-4H3,(H,39,50)(H,41,49)(H,42,52)(H,43,51)/t26-/m0/s1
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n/an/a 121n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304243
PNG
(US10143695, Compound 20)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(ccc45)S(C)(=O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O9S/c1-25-14-29-20-45-32-19-37(36(62-5)18-31(32)43(58)54(29)21-25)63-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(64(6,60)61)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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n/an/a 126n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304243
PNG
(US10143695, Compound 20)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(ccc45)S(C)(=O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C44H44N10O9S/c1-25-14-29-20-45-32-19-37(36(62-5)18-31(32)43(58)54(29)21-25)63-13-7-8-39(55)48-38-24-52(4)40(49-38)42(57)47-27-16-34(50(2)22-27)41(56)46-28-17-35(51(3)23-28)44(59)53-12-11-26-15-30(64(6,60)61)9-10-33(26)53/h9-12,15-20,22-24,29H,1,7-8,13-14,21H2,2-6H3,(H,46,56)(H,47,57)(H,48,55)/t29-/m0/s1
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UniChem
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n/an/a 202n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304236
PNG
(US10143695, Compound 3A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)NCc3ccc(N)cc3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C36H39N9O6/c1-21-12-25-17-38-27-15-30(29(50-4)14-26(27)36(49)45(25)18-21)51-11-5-6-32(46)41-31-20-44(3)33(42-31)35(48)40-24-13-28(43(2)19-24)34(47)39-16-22-7-9-23(37)10-8-22/h7-10,13-15,17,19-20,25H,1,5-6,11-12,16,18,37H2,2-4H3,(H,39,47)(H,40,48)(H,41,46)/t25-/m0/s1
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n/an/a 214n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304248
PNG
(US10143695, Compound 51)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C35H37N9O8/c1-19-9-22-14-36-24-13-28(27(51-5)12-23(24)34(48)44(22)15-19)52-8-6-7-30(45)39-29-18-43(4)31(40-29)33(47)38-20-10-25(41(2)16-20)32(46)37-21-11-26(35(49)50)42(3)17-21/h10-14,16-18,22H,1,6-9,15H2,2-5H3,(H,37,46)(H,38,47)(H,39,45)(H,49,50)/t22-/m0/s1
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n/an/a 260n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304248
PNG
(US10143695, Compound 51)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C35H37N9O8/c1-19-9-22-14-36-24-13-28(27(51-5)12-23(24)34(48)44(22)15-19)52-8-6-7-30(45)39-29-18-43(4)31(40-29)33(47)38-20-10-25(41(2)16-20)32(46)37-21-11-26(35(49)50)42(3)17-21/h10-14,16-18,22H,1,6-9,15H2,2-5H3,(H,37,46)(H,38,47)(H,39,45)(H,49,50)/t22-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304248
PNG
(US10143695, Compound 51)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C35H37N9O8/c1-19-9-22-14-36-24-13-28(27(51-5)12-23(24)34(48)44(22)15-19)52-8-6-7-30(45)39-29-18-43(4)31(40-29)33(47)38-20-10-25(41(2)16-20)32(46)37-21-11-26(35(49)50)42(3)17-21/h10-14,16-18,22H,1,6-9,15H2,2-5H3,(H,37,46)(H,38,47)(H,39,45)(H,49,50)/t22-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304248
PNG
(US10143695, Compound 51)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C35H37N9O8/c1-19-9-22-14-36-24-13-28(27(51-5)12-23(24)34(48)44(22)15-19)52-8-6-7-30(45)39-29-18-43(4)31(40-29)33(47)38-20-10-25(41(2)16-20)32(46)37-21-11-26(35(49)50)42(3)17-21/h10-14,16-18,22H,1,6-9,15H2,2-5H3,(H,37,46)(H,38,47)(H,39,45)(H,49,50)/t22-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304248
PNG
(US10143695, Compound 51)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(O)=O)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C35H37N9O8/c1-19-9-22-14-36-24-13-28(27(51-5)12-23(24)34(48)44(22)15-19)52-8-6-7-30(45)39-29-18-43(4)31(40-29)33(47)38-20-10-25(41(2)16-20)32(46)37-21-11-26(35(49)50)42(3)17-21/h10-14,16-18,22H,1,6-9,15H2,2-5H3,(H,37,46)(H,38,47)(H,39,45)(H,49,50)/t22-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (human))
BDBM304237
PNG
(US10143695, Compound 4A)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)NCc4ccc(N)cc4)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O
Show InChI InChI=1S/C42H45N11O7/c1-24-13-29-19-44-31-17-35(34(59-5)16-30(31)42(58)53(29)20-24)60-12-6-7-37(54)48-36-23-52(4)38(49-36)41(57)47-28-15-33(51(3)22-28)40(56)46-27-14-32(50(2)21-27)39(55)45-18-25-8-10-26(43)11-9-25/h8-11,14-17,19,21-23,29H,1,6-7,12-13,18,20,43H2,2-5H3,(H,45,55)(H,46,56)(H,47,57)(H,48,54)/t29-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...


US Patent US10143695 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%