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Patent code US10144742

Compile Data Set for Download or QSAR

Found 520 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306252
PNG
(US10144742, Compound I-414)
Show SMILES CC(C)Oc1nc2ccc(cc2nc1-c1cc(ccc1F)C#N)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H23FN6O2/c1-15(2)34-25-23(18-12-16(14-27)5-7-19(18)26)31-21-13-17(6-8-20(21)32-25)24(33)30-9-3-4-22-28-10-11-29-22/h5-8,10-13,15H,3-4,9H2,1-2H3,(H,28,29)(H,30,33)
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n/an/a<100n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306264
PNG
(US10144742, Compound I-426)
Show SMILES COc1cc(ccc1F)-c1nc2cc(ccc2nc1OC(C)C)C(=O)NCc1ccc2nccn2c1
Show InChI InChI=1S/C27H24FN5O3/c1-16(2)36-27-25(18-5-7-20(28)23(13-18)35-3)31-22-12-19(6-8-21(22)32-27)26(34)30-14-17-4-9-24-29-10-11-33(24)15-17/h4-13,15-16H,14H2,1-3H3,(H,30,34)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306277
PNG
(US10144742, Compound I-439)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCc1ccccc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C28H24FN5O2/c29-22-11-8-20(9-12-22)26-28(36-18-19-5-2-1-3-6-19)34-23-13-10-21(17-24(23)33-26)27(35)32-14-4-7-25-30-15-16-31-25/h1-3,5-6,8-13,15-17H,4,7,14,18H2,(H,30,31)(H,32,35)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306284
PNG
(US10144742, Compound I-446)
Show SMILES Cc1noc(C)c1COc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C27H25FN6O3/c1-16-21(17(2)37-34-16)15-36-27-25(18-5-8-20(28)9-6-18)32-23-14-19(7-10-22(23)33-27)26(35)31-11-3-4-24-29-12-13-30-24/h5-10,12-14H,3-4,11,15H2,1-2H3,(H,29,30)(H,31,35)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306337
PNG
(US10144742, Compound I-499)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(Cl)s1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H19ClFN5OS/c26-21-10-9-20(34-21)24-23(15-3-6-17(27)7-4-15)31-18-8-5-16(14-19(18)32-24)25(33)30-11-1-2-22-28-12-13-29-22/h3-10,12-14H,1-2,11H2,(H,28,29)(H,30,33)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306345
PNG
(US10144742, Compound I-507)
Show SMILES Cc1ccc(F)c(c1)-c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C28H23F2N5O/c1-17-4-10-22(30)21(15-17)27-26(18-5-8-20(29)9-6-18)34-23-11-7-19(16-24(23)35-27)28(36)33-12-2-3-25-31-13-14-32-25/h4-11,13-16H,2-3,12H2,1H3,(H,31,32)(H,33,36)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306347
PNG
(US10144742, Compound I-509)
Show SMILES CN(C)CCOc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H27FN6O2/c1-32(2)14-15-34-25-23(17-5-8-19(26)9-6-17)30-21-16-18(7-10-20(21)31-25)24(33)29-11-3-4-22-27-12-13-28-22/h5-10,12-13,16H,3-4,11,14-15H2,1-2H3,(H,27,28)(H,29,33)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306172
PNG
(US10144742, Compound I-334)
Show SMILES CC(C)Oc1nc2ccc(cc2nc1-c1ccc(Cl)s1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C22H22ClN5O2S/c1-13(2)30-22-20(17-7-8-18(23)31-17)27-16-12-14(5-6-15(16)28-22)21(29)26-9-3-4-19-24-10-11-25-19/h5-8,10-13H,3-4,9H2,1-2H3,(H,24,25)(H,26,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306177
PNG
(US10144742, Compound I-339)
Show SMILES CC(C)Oc1nc2ccc(cc2nc1-c1ccc(F)c(F)c1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C24H23F2N5O2/c1-14(2)33-24-22(15-5-7-17(25)18(26)12-15)30-20-13-16(6-8-19(20)31-24)23(32)29-9-3-4-21-27-10-11-28-21/h5-8,10-14H,3-4,9H2,1-2H3,(H,27,28)(H,29,32)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306178
PNG
(US10144742, Compound I-340)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1cccs1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H20FN5OS/c26-18-8-5-16(6-9-18)23-24(21-3-2-14-33-21)31-20-15-17(7-10-19(20)30-23)25(32)29-11-1-4-22-27-12-13-28-22/h2-3,5-10,12-15H,1,4,11H2,(H,27,28)(H,29,32)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306185
PNG
(US10144742, Compound I-347)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCc1cn[nH]c1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H22FN7O2/c26-19-6-3-17(4-7-19)23-25(35-15-16-13-30-31-14-16)33-20-8-5-18(12-21(20)32-23)24(34)29-9-1-2-22-27-10-11-28-22/h3-8,10-14H,1-2,9,15H2,(H,27,28)(H,29,34)(H,30,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306186
PNG
(US10144742, Compound I-348)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCC1COC1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H24FN5O3/c26-19-6-3-17(4-7-19)23-25(34-15-16-13-33-14-16)31-20-8-5-18(12-21(20)30-23)24(32)29-9-1-2-22-27-10-11-28-22/h3-8,10-12,16H,1-2,9,13-15H2,(H,27,28)(H,29,32)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306193
PNG
(US10144742, Compound I-355)
Show SMILES CCOc1cc(ccc1F)-c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C29H25F2N5O2/c1-2-38-25-17-19(7-11-22(25)31)28-27(18-5-9-21(30)10-6-18)35-23-12-8-20(16-24(23)36-28)29(37)34-13-3-4-26-32-14-15-33-26/h5-12,14-17H,2-4,13H2,1H3,(H,32,33)(H,34,37)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306199
PNG
(US10144742, Compound I-361)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(Cl)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C27H21ClFN5O/c28-20-8-3-17(4-9-20)26-25(18-5-10-21(29)11-6-18)33-22-12-7-19(16-23(22)34-26)27(35)32-13-1-2-24-30-14-15-31-24/h3-12,14-16H,1-2,13H2,(H,30,31)(H,32,35)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306219
PNG
(US10144742, Compound I-381)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1cc(ccc1Cl)C(F)(F)F)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C28H20ClF4N5O/c29-21-9-6-18(28(31,32)33)15-20(21)26-25(16-3-7-19(30)8-4-16)37-22-10-5-17(14-23(22)38-26)27(39)36-11-1-2-24-34-12-13-35-24/h3-10,12-15H,1-2,11H2,(H,34,35)(H,36,39)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306221
PNG
(US10144742, Compound I-383)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C27H29FN6O2/c1-17-15-34(16-18(2)36-17)26-25(19-5-8-21(28)9-6-19)32-23-14-20(7-10-22(23)33-26)27(35)31-11-3-4-24-29-12-13-30-24/h5-10,12-14,17-18H,3-4,11,15-16H2,1-2H3,(H,29,30)(H,31,35)/t17-,18+
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306227
PNG
(US10144742, Compound I-389)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1-n1ccc2cnccc12)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C28H22FN7O/c29-21-6-3-18(4-7-21)26-27(36-15-10-20-17-30-12-9-24(20)36)35-22-8-5-19(16-23(22)34-26)28(37)33-11-1-2-25-31-13-14-32-25/h3-10,12-17H,1-2,11H2,(H,31,32)(H,33,37)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306238
PNG
(US10144742, Compound I-400)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OC1CCCC1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C26H26FN5O2/c27-19-10-7-17(8-11-19)24-26(34-20-4-1-2-5-20)32-21-12-9-18(16-22(21)31-24)25(33)30-13-3-6-23-28-14-15-29-23/h7-12,14-16,20H,1-6,13H2,(H,28,29)(H,30,33)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306268
PNG
(US10144742, Compound I-430)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OC1CCCNC1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C26H27FN6O2/c27-19-8-5-17(6-9-19)24-26(35-20-3-1-11-28-16-20)33-21-10-7-18(15-22(21)32-24)25(34)31-12-2-4-23-29-13-14-30-23/h5-10,13-15,20,28H,1-4,11-12,16H2,(H,29,30)(H,31,34)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306283
PNG
(US10144742, Compound I-445)
Show SMILES Cc1ccc(cc1-c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1)C(F)(F)F
Show InChI InChI=1S/C29H23F4N5O/c1-17-4-8-20(29(31,32)33)16-22(17)27-26(18-5-9-21(30)10-6-18)37-23-11-7-19(15-24(23)38-27)28(39)36-12-2-3-25-34-13-14-35-25/h4-11,13-16H,2-3,12H2,1H3,(H,34,35)(H,36,39)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306288
PNG
(US10144742, Compound I-450)
Show SMILES Cc1ccc(C)c(c1)-c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C29H26FN5O/c1-18-5-6-19(2)23(16-18)28-27(20-7-10-22(30)11-8-20)34-24-12-9-21(17-25(24)35-28)29(36)33-13-3-4-26-31-14-15-32-26/h5-12,14-17H,3-4,13H2,1-2H3,(H,31,32)(H,33,36)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306295
PNG
(US10144742, Compound I-457)
Show SMILES COC1CCN(C1)c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C26H27FN6O2/c1-35-20-10-14-33(16-20)25-24(17-4-7-19(27)8-5-17)31-22-15-18(6-9-21(22)32-25)26(34)30-11-2-3-23-28-12-13-29-23/h4-9,12-13,15,20H,2-3,10-11,14,16H2,1H3,(H,28,29)(H,30,34)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306302
PNG
(US10144742, Compound I-464)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCc1nc2cnccc2[nH]1
Show InChI InChI=1S/C28H18F2N6O/c29-19-6-1-16(2-7-19)26-27(17-3-8-20(30)9-4-17)36-23-13-18(5-10-21(23)35-26)28(37)32-15-25-33-22-11-12-31-14-24(22)34-25/h1-14H,15H2,(H,32,37)(H,33,34)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306303
PNG
(US10144742, Compound I-465)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1N1CCCC1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H25FN6O/c26-19-8-5-17(6-9-19)23-24(32-14-1-2-15-32)31-20-10-7-18(16-21(20)30-23)25(33)29-11-3-4-22-27-12-13-28-22/h5-10,12-13,16H,1-4,11,14-15H2,(H,27,28)(H,29,33)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306306
PNG
(US10144742, Compound I-468)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1O[C@H]1CCOC1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H24FN5O3/c26-18-6-3-16(4-7-18)23-25(34-19-9-13-33-15-19)31-20-8-5-17(14-21(20)30-23)24(32)29-10-1-2-22-27-11-12-28-22/h3-8,11-12,14,19H,1-2,9-10,13,15H2,(H,27,28)(H,29,32)/t19-/m0/s1
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306315
PNG
(US10144742, Compound I-477)
Show SMILES O=C(NCCCc1ncc[nH]1)c1ccc2nc(-c3ccccc3)c(nc2c1)-c1cccs1
Show InChI InChI=1S/C25H21N5OS/c31-25(28-12-4-9-22-26-13-14-27-22)18-10-11-19-20(16-18)30-24(21-8-5-15-32-21)23(29-19)17-6-2-1-3-7-17/h1-3,5-8,10-11,13-16H,4,9,12H2,(H,26,27)(H,28,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306326
PNG
(US10144742, Compound I-488)
Show SMILES COc1cc(ccc1F)-c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C28H23F2N5O2/c1-37-24-16-18(6-10-21(24)30)27-26(17-4-8-20(29)9-5-17)34-22-11-7-19(15-23(22)35-27)28(36)33-12-2-3-25-31-13-14-32-25/h4-11,13-16H,2-3,12H2,1H3,(H,31,32)(H,33,36)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306343
PNG
(US10144742, Compound I-505)
Show SMILES CN1CCCC1CCOc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C28H31FN6O2/c1-35-16-3-4-22(35)12-17-37-28-26(19-6-9-21(29)10-7-19)33-24-18-20(8-11-23(24)34-28)27(36)32-13-2-5-25-30-14-15-31-25/h6-11,14-15,18,22H,2-5,12-13,16-17H2,1H3,(H,30,31)(H,32,36)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306357
PNG
(US10144742, Compound I-519)
Show SMILES COc1cc(c(F)cn1)-c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(=O)NCCCc1nccn1C
Show InChI InChI=1S/C28H24F2N6O2/c1-36-13-12-31-24(36)4-3-11-32-28(37)18-7-10-22-23(14-18)35-27(20-15-25(38-2)33-16-21(20)30)26(34-22)17-5-8-19(29)9-6-17/h5-10,12-16H,3-4,11H2,1-2H3,(H,32,37)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM305850
PNG
(US10144742, Compound I-12)
Show SMILES C=CC(=O)N1CC[C@H](C1)Nc1ncnc2[nH]c(cc12)C#Cc1ccccc1
Show InChI InChI=1S/C21H19N5O/c1-2-19(27)26-11-10-17(13-26)25-21-18-12-16(24-20(18)22-14-23-21)9-8-15-6-4-3-5-7-15/h2-7,12,14,17H,1,10-11,13H2,(H2,22,23,24,25)/t17-/m1/s1
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM305902
PNG
(US10144742, Compound I-64)
Show SMILES COc1ccccc1OCC#Cc1nc2c(N[C@@H]3CCN(C3)C(=O)C=C)ncnc2[nH]1
Show InChI InChI=1S/C22H22N6O3/c1-3-19(29)28-11-10-15(13-28)25-21-20-22(24-14-23-21)27-18(26-20)9-6-12-31-17-8-5-4-7-16(17)30-2/h3-5,7-8,14-15H,1,10-13H2,2H3,(H2,23,24,25,26,27)/t15-/m1/s1
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM305908
PNG
(US10144742, Compound I-70)
Show SMILES COc1cccc(c1)-c1nc2cc(ccc2nc1N1CCC(CC1)N1CCOCC1)C(=O)NCCCc1cccnc1
Show InChI InChI=1S/C33H38N6O3/c1-41-28-8-2-7-25(21-28)31-32(39-15-11-27(12-16-39)38-17-19-42-20-18-38)37-29-10-9-26(22-30(29)36-31)33(40)35-14-4-6-24-5-3-13-34-23-24/h2-3,5,7-10,13,21-23,27H,4,6,11-12,14-20H2,1H3,(H,35,40)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM305943
PNG
(US10144742, Compound I-105)
Show SMILES OC1CCN(CC1)c1nc2ccc(cc2nc1-c1ccccc1)C(=O)NCCCn1ccnc1
Show InChI InChI=1S/C26H28N6O2/c33-21-9-14-32(15-10-21)25-24(19-5-2-1-3-6-19)29-23-17-20(7-8-22(23)30-25)26(34)28-11-4-13-31-16-12-27-18-31/h1-3,5-8,12,16-18,21,33H,4,9-11,13-15H2,(H,28,34)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM305952
PNG
(US10144742, Compound I-114)
Show SMILES OC1CCN(CC1)c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCOc1cccnc1
Show InChI InChI=1S/C27H26FN5O3/c28-20-6-3-18(4-7-20)25-26(33-13-9-21(34)10-14-33)32-23-8-5-19(16-24(23)31-25)27(35)30-12-15-36-22-2-1-11-29-17-22/h1-8,11,16-17,21,34H,9-10,12-15H2,(H,30,35)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306042
PNG
(US10144742, Compound I-204)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1N1CCC(CC1)N1CCOCC1)C(=O)NCc1cn2cccnc2n1
Show InChI InChI=1S/C31H31FN8O2/c32-23-5-2-21(3-6-23)28-29(39-12-8-25(9-13-39)38-14-16-42-17-15-38)37-26-7-4-22(18-27(26)36-28)30(41)34-19-24-20-40-11-1-10-33-31(40)35-24/h1-7,10-11,18,20,25H,8-9,12-17,19H2,(H,34,41)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306048
PNG
(US10144742, Compound I-210)
Show SMILES OC1CCN(CC1)C1CCN(CC1)c1nc2ccc(cc2nc1-c1ccccc1)C(=O)NCCCn1ccnc1
Show InChI InChI=1S/C31H37N7O2/c39-26-11-18-37(19-12-26)25-9-16-38(17-10-25)30-29(23-5-2-1-3-6-23)34-28-21-24(7-8-27(28)35-30)31(40)33-13-4-15-36-20-14-32-22-36/h1-3,5-8,14,20-22,25-26,39H,4,9-13,15-19H2,(H,33,40)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306060
PNG
(US10144742, Compound I-222)
Show SMILES CC(C)Oc1nc2ccc(cc2nc1-c1ccc(Cl)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C24H24ClN5O2/c1-15(2)32-24-22(16-5-8-18(25)9-6-16)29-20-14-17(7-10-19(20)30-24)23(31)28-11-3-4-21-26-12-13-27-21/h5-10,12-15H,3-4,11H2,1-2H3,(H,26,27)(H,28,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306113
PNG
(US10144742, Compound I-275)
Show SMILES O=C(NCCCn1ccnc1)c1ccc2nc(N3CCC4(CC3)OCCO4)c(nc2c1)-c1ccccc1
Show InChI InChI=1S/C28H30N6O3/c35-27(30-11-4-13-33-16-12-29-20-33)22-7-8-23-24(19-22)31-25(21-5-2-1-3-6-21)26(32-23)34-14-9-28(10-15-34)36-17-18-37-28/h1-3,5-8,12,16,19-20H,4,9-11,13-15,17-18H2,(H,30,35)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306125
PNG
(US10144742, Compound I-287)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1N1CCS(=O)(=O)CC1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H25FN6O3S/c26-19-6-3-17(4-7-19)23-24(32-12-14-36(34,35)15-13-32)31-20-8-5-18(16-21(20)30-23)25(33)29-9-1-2-22-27-10-11-28-22/h3-8,10-11,16H,1-2,9,12-15H2,(H,27,28)(H,29,33)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306157
PNG
(US10144742, Compound I-319)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1cc(F)ccc1F)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C27H20F3N5O/c28-18-6-3-16(4-7-18)25-26(20-15-19(29)8-9-21(20)30)35-23-14-17(5-10-22(23)34-25)27(36)33-11-1-2-24-31-12-13-32-24/h3-10,12-15H,1-2,11H2,(H,31,32)(H,33,36)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306167
PNG
(US10144742, Compound I-329)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCC1CCC1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C26H26FN5O2/c27-20-9-6-18(7-10-20)24-26(34-16-17-3-1-4-17)32-21-11-8-19(15-22(21)31-24)25(33)30-12-2-5-23-28-13-14-29-23/h6-11,13-15,17H,1-5,12,16H2,(H,28,29)(H,30,33)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306187
PNG
(US10144742, Compound I-349)
Show SMILES CC(Oc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1)c1ccccc1
Show InChI InChI=1S/C29H26FN5O2/c1-19(20-6-3-2-4-7-20)37-29-27(21-9-12-23(30)13-10-21)34-25-18-22(11-14-24(25)35-29)28(36)33-15-5-8-26-31-16-17-32-26/h2-4,6-7,9-14,16-19H,5,8,15H2,1H3,(H,31,32)(H,33,36)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306216
PNG
(US10144742, Compound I-378)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCC1CC2(COC2)C1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C28H28FN5O3/c29-21-6-3-19(4-7-21)25-27(37-15-18-13-28(14-18)16-36-17-28)34-22-8-5-20(12-23(22)33-25)26(35)32-9-1-2-24-30-10-11-31-24/h3-8,10-12,18H,1-2,9,13-17H2,(H,30,31)(H,32,35)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306223
PNG
(US10144742, Compound I-385)
Show SMILES CC(C)Oc1nc2ccc(cc2nc1-c1cccs1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C22H23N5O2S/c1-14(2)29-22-20(18-5-4-12-30-18)26-17-13-15(7-8-16(17)27-22)21(28)25-9-3-6-19-23-10-11-24-19/h4-5,7-8,10-14H,3,6,9H2,1-2H3,(H,23,24)(H,25,28)
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n/an/a<100n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306235
PNG
(US10144742, Compound I-397)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(Cl)c(Cl)c1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C27H20Cl2FN5O/c28-20-9-5-17(14-21(20)29)26-25(16-3-7-19(30)8-4-16)34-22-10-6-18(15-23(22)35-26)27(36)33-11-1-2-24-31-12-13-32-24/h3-10,12-15H,1-2,11H2,(H,31,32)(H,33,36)
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n/an/a<100n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306265
PNG
(US10144742, Compound I-427)
Show SMILES COC1CC(C1)Oc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C26H26FN5O3/c1-34-19-14-20(15-19)35-26-24(16-4-7-18(27)8-5-16)31-22-13-17(6-9-21(22)32-26)25(33)30-10-2-3-23-28-11-12-29-23/h4-9,11-13,19-20H,2-3,10,14-15H2,1H3,(H,28,29)(H,30,33)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306278
PNG
(US10144742, Compound I-440)
Show SMILES CCOc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C23H22FN5O2/c1-2-31-23-21(15-5-8-17(24)9-6-15)28-19-14-16(7-10-18(19)29-23)22(30)27-11-3-4-20-25-12-13-26-20/h5-10,12-14H,2-4,11H2,1H3,(H,25,26)(H,27,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306292
PNG
(US10144742, Compound I-454)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCc1ccccc1Cl)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C28H23ClFN5O2/c29-22-5-2-1-4-20(22)17-37-28-26(18-7-10-21(30)11-8-18)34-24-16-19(9-12-23(24)35-28)27(36)33-13-3-6-25-31-14-15-32-25/h1-2,4-5,7-12,14-16H,3,6,13,17H2,(H,31,32)(H,33,36)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306300
PNG
(US10144742, Compound I-462)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCC#C)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C24H20FN5O2/c1-2-14-32-24-22(16-5-8-18(25)9-6-16)29-20-15-17(7-10-19(20)30-24)23(31)28-11-3-4-21-26-12-13-27-21/h1,5-10,12-13,15H,3-4,11,14H2,(H,26,27)(H,28,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306307
PNG
(US10144742, Compound I-469)
Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2nc1OCc1nccs1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H21FN6O2S/c26-18-6-3-16(4-7-18)23-25(34-15-22-29-12-13-35-22)32-19-8-5-17(14-20(19)31-23)24(33)30-9-1-2-21-27-10-11-28-21/h3-8,10-14H,1-2,9,15H2,(H,27,28)(H,30,33)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%