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Patent code US10149841

Compile Data Set for Download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306798
PNG
(US10149841, Compound 9)
Show SMILES OC(=O)CNC(=O)c1ncc(Oc2cccc(F)c2F)cc1O
Show InChI InChI=1S/C14H10F2N2O5/c15-8-2-1-3-10(12(8)16)23-7-4-9(19)13(17-5-7)14(22)18-6-11(20)21/h1-5,19H,6H2,(H,18,22)(H,20,21)
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306799
PNG
(US10149841, Compound 19)
Show SMILES Cc1ccc(Oc2cnc(C(=O)NCC(O)=O)c(O)c2)c(C)c1
Show InChI InChI=1S/C16H16N2O5/c1-9-3-4-13(10(2)5-9)23-11-6-12(19)15(17-7-11)16(22)18-8-14(20)21/h3-7,19H,8H2,1-2H3,(H,18,22)(H,20,21)
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.30E+4n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306795
PNG
(US10149841, Compound 1)
Show SMILES OC(=O)CNC(=O)c1ncc(Oc2ccccc2)cc1O
Show InChI InChI=1S/C14H12N2O5/c17-11-6-10(21-9-4-2-1-3-5-9)7-15-13(11)14(20)16-8-12(18)19/h1-7,17H,8H2,(H,16,20)(H,18,19)
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 8.40E+4n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306797
PNG
(US10149841, Compound 8)
Show SMILES OC(=O)CNC(=O)c1ncc(Oc2ccc3ccccc3c2)cc1O
Show InChI InChI=1S/C18H14N2O5/c21-15-8-14(9-19-17(15)18(24)20-10-16(22)23)25-13-6-5-11-3-1-2-4-12(11)7-13/h1-9,21H,10H2,(H,20,24)(H,22,23)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 9.10E+4n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306800
PNG
(US10149841, Compound 22)
Show SMILES OC(=O)CNC(=O)c1ncc(Oc2cccc(F)c2)cc1O
Show InChI InChI=1S/C14H11FN2O5/c15-8-2-1-3-9(4-8)22-10-5-11(18)13(16-6-10)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.36E+5n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306796
PNG
(US10149841, Compound 5)
Show SMILES Cc1cccc(Oc2cnc(C(=O)NCC(O)=O)c(O)c2)c1C
Show InChI InChI=1S/C16H16N2O5/c1-9-4-3-5-13(10(9)2)23-11-6-12(19)15(17-7-11)16(22)18-8-14(20)21/h3-7,19H,8H2,1-2H3,(H,18,22)(H,20,21)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
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GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.37E+5n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%