BindingDB logo
myBDB logout

Patent code US10150755

Compile Data Set for Download or QSAR

Found 254 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307667
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cccnn1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H17N7O/c30-22-17-11-14(18-4-2-10-23-26-18)6-7-15(17)12-28(22)20-5-1-3-19(25-20)21-27-24-13-29(21)16-8-9-16/h1-7,10-11,13,16H,8-9,12H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens)
BDBM307668
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cnc(cn1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H21N7O/c33-25-19-10-16(22-12-26-21(11-27-22)15-4-5-15)6-7-17(19)13-31(25)23-3-1-2-20(29-23)24-30-28-14-32(24)18-8-9-18/h1-3,6-7,10-12,14-15,18H,4-5,8-9,13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307654
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1ccc(nc1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H22N6O/c33-26-21-12-17(18-8-11-22(27-13-18)16-4-5-16)6-7-19(21)14-31(26)24-3-1-2-23(29-24)25-30-28-15-32(25)20-9-10-20/h1-3,6-8,11-13,15-16,20H,4-5,9-10,14H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307671
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES Fc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17FN6O/c24-19-9-15-12-29(23(31)18(15)10-17(19)14-3-2-8-25-11-14)21-5-1-4-20(27-21)22-28-26-13-30(22)16-6-7-16/h1-5,8-11,13,16H,6-7,12H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307672
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES Cc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-10-17-13-29(24(31)20(17)11-19(15)16-4-3-9-25-12-16)22-6-2-5-21(27-22)23-28-26-14-30(23)18-7-8-18/h2-6,9-12,14,18H,7-8,13H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307679
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES O=C(N1CCCC1)c1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C28H25N7O2/c36-27(33-11-1-2-12-33)23-13-19-16-34(28(37)22(19)14-21(23)18-5-4-10-29-15-18)25-7-3-6-24(31-25)26-32-30-17-35(26)20-8-9-20/h3-7,10,13-15,17,20H,1-2,8-9,11-12,16H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307680
PNG
(Preparation of methyl 2-(6-(4-cyclopropyl-4H-1,2,4...)
Show SMILES COC(=O)c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C20H17N5O3/c1-28-20(27)12-5-6-13-10-24(19(26)15(13)9-12)17-4-2-3-16(22-17)18-23-21-11-25(18)14-7-8-14/h2-6,9,11,14H,7-8,10H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens)
BDBM307686
PNG
(Preparation of 2-(6-(5-methyl-6,7-dihydro-5H-pyrro...)
Show SMILES CC1CCc2nnc(-c3cccc(n3)N3Cc4ccccc4C3=O)n12
Show InChI InChI=1S/C19H17N5O/c1-12-9-10-17-21-22-18(24(12)17)15-7-4-8-16(20-15)23-11-13-5-2-3-6-14(13)19(23)25/h2-8,12H,9-11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307690
PNG
(US10150755, Compound 82)
Show SMILES C[C@@H]1CCc2nnc(-c3cccc(n3)N3Cc4ccccc4C3=O)n12
Show InChI InChI=1S/C19H17N5O/c1-12-9-10-17-21-22-18(24(12)17)15-7-4-8-16(20-15)23-11-13-5-2-3-6-14(13)19(23)25/h2-8,12H,9-11H2,1H3/t12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307618
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H25N7O2/c1-28-9-11-29(12-10-28)23(32)16-5-8-19-17(13-16)14-30(24(19)33)21-4-2-3-20(26-21)22-27-25-15-31(22)18-6-7-18/h2-5,8,13,15,18H,6-7,9-12,14H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307619
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C(N1CCCCC1)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H24N6O2/c31-23(28-11-2-1-3-12-28)16-7-10-19-17(13-16)14-29(24(19)32)21-6-4-5-20(26-21)22-27-25-15-30(22)18-8-9-18/h4-7,10,13,15,18H,1-3,8-9,11-12,14H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307620
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES OC1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H24N6O3/c31-18-8-10-28(11-9-18)23(32)15-4-7-19-16(12-15)13-29(24(19)33)21-3-1-2-20(26-21)22-27-25-14-30(22)17-5-6-17/h1-4,7,12,14,17-18,31H,5-6,8-11,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307625
PNG
(N-(1-(2-(6-(4- cyclopropyl-4H- 1,2,4-triazol-3- yl...)
Show SMILES CC(=O)NC1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H27N7O3/c1-16(34)28-19-9-11-31(12-10-19)25(35)17-5-8-21-18(13-17)14-32(26(21)36)23-4-2-3-22(29-23)24-30-27-15-33(24)20-6-7-20/h2-5,8,13,15,19-20H,6-7,9-12,14H2,1H3,(H,28,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307631
PNG
(US10150755, Compound 23 | methyl 1-(2-(6-(4- cyclo...)
Show SMILES COC(=O)C1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H26N6O4/c1-36-26(35)16-9-11-30(12-10-16)24(33)17-5-8-20-18(13-17)14-31(25(20)34)22-4-2-3-21(28-22)23-29-27-15-32(23)19-6-7-19/h2-5,8,13,15-16,19H,6-7,9-12,14H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307644
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES Cn1cncc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-12-23-10-19(27)14-5-6-15-11-28(22(30)17(15)9-14)20-4-2-3-18(25-20)21-26-24-13-29(21)16-7-8-16/h2-6,9-10,12-13,16H,7-8,11H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307649
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ccncc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-9-10-25-12-20(15)16-5-6-17-13-29(24(31)19(17)11-16)22-4-2-3-21(27-22)23-28-26-14-30(23)18-7-8-18/h2-6,9-12,14,18H,7-8,13H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307653
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES COc1ccc(cn1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O2/c1-32-22-10-7-16(12-25-22)15-5-6-17-13-29(24(31)19(17)11-15)21-4-2-3-20(27-21)23-28-26-14-30(23)18-8-9-18/h2-7,10-12,14,18H,8-9,13H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307659
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ncc(s1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H18N6OS/c1-13-23-10-19(30-13)14-5-6-15-11-27(22(29)17(15)9-14)20-4-2-3-18(25-20)21-26-24-12-28(21)16-7-8-16/h2-6,9-10,12,16H,7-8,11H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307664
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cnc(nc1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H21N7O/c33-25-20-10-16(18-11-26-23(27-12-18)15-4-5-15)6-7-17(20)13-31(25)22-3-1-2-21(29-22)24-30-28-14-32(24)19-8-9-19/h1-3,6-7,10-12,14-15,19H,4-5,8-9,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307681
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES OC(=O)c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C19H15N5O3/c25-18-14-8-11(19(26)27)4-5-12(14)9-23(18)16-3-1-2-15(21-16)17-22-20-10-24(17)13-6-7-13/h1-5,8,10,13H,6-7,9H2,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307693
PNG
(Preparation of 2-(6-(4-isopropyl-4H-1,2,4-triazol-...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(cc2C1=O)-c1cccnc1
Show InChI InChI=1S/C23H20N6O/c1-15(2)29-14-25-27-22(29)20-6-3-7-21(26-20)28-13-18-9-8-16(11-19(18)23(28)30)17-5-4-10-24-12-17/h3-12,14-15H,13H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307622
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES COC1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H26N6O3/c1-34-19-9-11-29(12-10-19)24(32)16-5-8-20-17(13-16)14-30(25(20)33)22-4-2-3-21(27-22)23-28-26-15-31(23)18-6-7-18/h2-5,8,13,15,18-19H,6-7,9-12,14H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307636
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2cc(ccc12)-c1cc[nH]n1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C21H17N7O/c29-21-16-7-4-13(17-8-9-22-25-17)10-14(16)11-27(21)19-3-1-2-18(24-19)20-26-23-12-28(20)15-5-6-15/h1-4,7-10,12,15H,5-6,11H2,(H,22,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307638
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cn1cnc(c1)-c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-11-19(23-12-27)14-5-8-17-15(9-14)10-28(22(17)30)20-4-2-3-18(25-20)21-26-24-13-29(21)16-6-7-16/h2-5,8-9,11-13,16H,6-7,10H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307639
PNG
(Preparation of 5-amino-2-(6-(4-cyclopropyl-4H-1,2,...)
Show SMILES Nc1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C18H16N6O/c19-12-4-7-14-11(8-12)9-23(18(14)25)16-3-1-2-15(21-16)17-22-20-10-24(17)13-5-6-13/h1-4,7-8,10,13H,5-6,9,19H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307651
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cncnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H17N7O/c30-22-18-8-14(16-9-23-12-24-10-16)4-5-15(18)11-28(22)20-3-1-2-19(26-20)21-27-25-13-29(21)17-6-7-17/h1-5,8-10,12-13,17H,6-7,11H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307661
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Fc1ncccc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17FN6O/c24-21-17(3-2-10-25-21)14-6-7-15-12-29(23(31)18(15)11-14)20-5-1-4-19(27-20)22-28-26-13-30(22)16-8-9-16/h1-7,10-11,13,16H,8-9,12H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307673
PNG
(Preparation of 5-chloro-2-(6-(4-cyclopropyl-4H-1,2...)
Show SMILES Clc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H17ClN6O/c24-19-9-15-12-29(23(31)18(15)10-17(19)14-3-2-8-25-11-14)21-5-1-4-20(27-21)22-28-26-13-30(22)16-6-7-16/h1-5,8-11,13,16H,6-7,12H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307676
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES CC(C)Oc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H24N6O2/c1-16(2)34-23-11-18-14-31(26(33)21(18)12-20(23)17-5-4-10-27-13-17)24-7-3-6-22(29-24)25-30-28-15-32(25)19-8-9-19/h3-7,10-13,15-16,19H,8-9,14H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307686
PNG
(Preparation of 2-(6-(5-methyl-6,7-dihydro-5H-pyrro...)
Show SMILES CC1CCc2nnc(-c3cccc(n3)N3Cc4ccccc4C3=O)n12
Show InChI InChI=1S/C19H17N5O/c1-12-9-10-17-21-22-18(24(12)17)15-7-4-8-16(20-15)23-11-13-5-2-3-6-14(13)19(23)25/h2-8,12H,9-11H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307612
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES COCCNC(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H22N6O3/c1-31-10-9-23-21(29)14-5-8-17-15(11-14)12-27(22(17)30)19-4-2-3-18(25-19)20-26-24-13-28(20)16-6-7-16/h2-5,8,11,13,16H,6-7,9-10,12H2,1H3,(H,23,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307615
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C(N1CCOCC1)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H22N6O3/c30-22(27-8-10-32-11-9-27)15-4-7-18-16(12-15)13-28(23(18)31)20-3-1-2-19(25-20)21-26-24-14-29(21)17-5-6-17/h1-4,7,12,14,17H,5-6,8-11,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307628
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C(N1CCNC(=O)C1)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H21N7O3/c31-20-12-28(9-8-24-20)22(32)14-4-7-17-15(10-14)11-29(23(17)33)19-3-1-2-18(26-19)21-27-25-13-30(21)16-5-6-16/h1-4,7,10,13,16H,5-6,8-9,11-12H2,(H,24,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307647
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES Cn1ccc(n1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-10-9-18(26-27)14-5-6-15-12-28(22(30)17(15)11-14)20-4-2-3-19(24-20)21-25-23-13-29(21)16-7-8-16/h2-6,9-11,13,16H,7-8,12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307668
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C1N(Cc2ccc(cc12)-c1cnc(cn1)C1CC1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H21N7O/c33-25-19-10-16(22-12-26-21(11-27-22)15-4-5-15)6-7-17(19)13-31(25)23-3-1-2-20(29-23)24-30-28-14-32(24)18-8-9-18/h1-3,6-7,10-12,14-15,18H,4-5,8-9,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens)
BDBM307672
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES Cc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-10-17-13-29(24(31)20(17)11-19(15)16-4-3-9-25-12-16)22-6-2-5-21(27-22)23-28-26-14-30(23)18-7-8-18/h2-6,9-12,14,18H,7-8,13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens)
BDBM307674
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES COc1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O2/c1-32-21-10-16-13-29(24(31)19(16)11-18(21)15-4-3-9-25-12-15)22-6-2-5-20(27-22)23-28-26-14-30(23)17-7-8-17/h2-6,9-12,14,17H,7-8,13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307678
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES COC(=O)c1cc2CN(C(=O)c2cc1-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H20N6O3/c1-34-25(33)20-10-16-13-30(24(32)19(16)11-18(20)15-4-3-9-26-12-15)22-6-2-5-21(28-22)23-29-27-14-31(23)17-7-8-17/h2-6,9-12,14,17H,7-8,13H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Myosin light chain kinase, smooth muscle


(Homo sapiens)
BDBM307609
PNG
(Preparation of 2-(6-(4-Cyclopropyl-4H-1,2,4-triazo...)
Show SMILES O=C1N(Cc2ccccc12)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C18H15N5O/c24-18-14-5-2-1-4-12(14)10-22(18)16-7-3-6-15(20-16)17-21-19-11-23(17)13-8-9-13/h1-7,11,13H,8-10H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307682
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES CN(C)C(=O)c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C21H20N6O2/c1-25(2)20(28)13-6-7-14-11-26(21(29)16(14)10-13)18-5-3-4-17(23-18)19-24-22-12-27(19)15-8-9-15/h3-7,10,12,15H,8-9,11H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307613
PNG
(N-(2-(1H-imidazol- 1-yl)ethyl)-2-(6-(4- cyclopropy...)
Show SMILES O=C(NCCn1ccnc1)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H22N8O2/c33-23(26-9-11-30-10-8-25-14-30)16-4-7-19-17(12-16)13-31(24(19)34)21-3-1-2-20(28-21)22-29-27-15-32(22)18-5-6-18/h1-4,7-8,10,12,14-15,18H,5-6,9,11,13H2,(H,26,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307621
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES CC1(O)CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H26N6O3/c1-25(34)9-11-29(12-10-25)23(32)16-5-8-19-17(13-16)14-30(24(19)33)21-4-2-3-20(27-21)22-28-26-15-31(22)18-6-7-18/h2-5,8,13,15,18,34H,6-7,9-12,14H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307626
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES O=C(N1CCCC1)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H22N6O2/c30-22(27-10-1-2-11-27)15-6-9-18-16(12-15)13-28(23(18)31)20-5-3-4-19(25-20)21-26-24-14-29(21)17-7-8-17/h3-6,9,12,14,17H,1-2,7-8,10-11,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307633
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES CSC1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H26N6O2S/c1-34-19-9-11-29(12-10-19)24(32)16-5-8-20-17(13-16)14-30(25(20)33)22-4-2-3-21(27-22)23-28-26-15-31(23)18-6-7-18/h2-5,8,13,15,18-19H,6-7,9-12,14H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307652
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ncc(cn1)-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C23H19N7O/c1-14-24-10-17(11-25-14)15-5-6-16-12-29(23(31)19(16)9-15)21-4-2-3-20(27-21)22-28-26-13-30(22)18-7-8-18/h2-6,9-11,13,18H,7-8,12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307660
PNG
(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Show SMILES Cc1ncccc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H20N6O/c1-15-19(4-3-11-25-15)16-7-8-17-13-29(24(31)20(17)12-16)22-6-2-5-21(27-22)23-28-26-14-30(23)18-9-10-18/h2-8,11-12,14,18H,9-10,13H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307665
PNG
(Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Show SMILES Cn1ccnc1-c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C22H19N7O/c1-27-10-9-23-20(27)14-5-6-15-12-28(22(30)17(15)11-14)19-4-2-3-18(25-19)21-26-24-13-29(21)16-7-8-16/h2-6,9-11,13,16H,7-8,12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307677
PNG
(US10150755, Compound 69)
Show SMILES O=C1N(Cc2cc(OC3CCCC3)c(cc12)-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C28H26N6O2/c35-28-23-14-22(18-5-4-12-29-15-18)25(36-21-6-1-2-7-21)13-19(23)16-33(28)26-9-3-8-24(31-26)27-32-30-17-34(27)20-10-11-20/h3-5,8-9,12-15,17,20-21H,1-2,6-7,10-11,16H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307687
PNG
(Preparation of (R)-2-(6-(5-(hydroxymethyl)-6,7-dih...)
Show SMILES OC[C@H]1CCc2nnc(-c3cccc(n3)N3Cc4ccccc4C3=O)n12
Show InChI InChI=1S/C19H17N5O2/c25-11-13-8-9-17-21-22-18(24(13)17)15-6-3-7-16(20-15)23-10-12-4-1-2-5-14(12)19(23)26/h1-7,13,25H,8-11H2/t13-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM307609
PNG
(Preparation of 2-(6-(4-Cyclopropyl-4H-1,2,4-triazo...)
Show SMILES O=C1N(Cc2ccccc12)c1cccc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C18H15N5O/c24-18-14-5-2-1-4-12(14)10-22(18)16-7-3-6-15(20-16)17-21-19-11-23(17)13-8-9-13/h1-7,11,13H,8-10H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<200n/an/an/an/an/an/an/an/a



SEAL ROCK THERAPEUTICS, INC.

US Patent


Assay Description
The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...


US Patent US10150755 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 254 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%